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Conserved domains on  [gi|1958661666|ref|XP_038943035|]
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lipase maturation factor 1 isoform X2 [Rattus norvegicus]

Protein Classification

lipase maturation factor family protein( domain architecture ID 10535984)

lipase maturation factor family protein similar to vertebrate lipase maturation factor, which is involved in the maturation of specific proteins in the endoplasmic reticulum, and may be required for maturation and transport of active lipoprotein lipase through the secretory pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 1-310 1.81e-127

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


:

Pssm-ID: 462004  Cd Length: 419  Bit Score: 371.28  E-value: 1.81e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661666   1 MDFHYETQPVPNPMAYYLHRSPRWFHRFETLSNHFLELLVPFFLFLG-RRMCVLHGVLQILFQVVLIISGNLSFLNWLTI 79
Cdd:pfam06762  70 LDYHYETQPLPTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPiRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTI 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661666  80 VPSLACFDDATLGFLFPSGPRGLKKRVLE--------------MQREDAQRVQPKPRYLGCVVRQAANISLGI-LVAWLS 144
Cdd:pfam06762 150 VLSLSLLDDAFLYFWTPESRKKPPRTRLLsvietllsllvyglLIYGTVSLFGLKISENGTFLRRVTLPSIVLgLVSLLS 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661666 145 VPVVINLLSSK-------------------------------QVMNTSFNPLRIVNTYGAFGSITKERTEVILQGTANPN 193
Cdd:pfam06762 230 VPVCALLRSNKliqsiqlaivtlaavllfalslvpfsvrnllSRMNASFNPLHLVNSYGLFGSMTGGRPEVVIEGSNDGE 309

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661666 194 asapdAVWEDYEFKCKPGDPWRRPCLISPYHYRLDWLMWFAAFQTYEQNEWIIHLTGKLLADDAEALSLLALNPFEGRaP 273
Cdd:pfam06762 310 -----GPWKEYEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPWFLSLLYRLLQNDPEVLGLLDHNPFPDK-P 383

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1958661666 274 PRWIRGEHYRYKFSLPgGQHAAQGKWWIRKRIGPYFP 310
Cdd:pfam06762 384 PKYVRAELYRYRFTTP-GERRATGAWWKRERVGEYFP 419
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 1-310 1.81e-127

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 371.28  E-value: 1.81e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661666   1 MDFHYETQPVPNPMAYYLHRSPRWFHRFETLSNHFLELLVPFFLFLG-RRMCVLHGVLQILFQVVLIISGNLSFLNWLTI 79
Cdd:pfam06762  70 LDYHYETQPLPTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPiRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTI 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661666  80 VPSLACFDDATLGFLFPSGPRGLKKRVLE--------------MQREDAQRVQPKPRYLGCVVRQAANISLGI-LVAWLS 144
Cdd:pfam06762 150 VLSLSLLDDAFLYFWTPESRKKPPRTRLLsvietllsllvyglLIYGTVSLFGLKISENGTFLRRVTLPSIVLgLVSLLS 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661666 145 VPVVINLLSSK-------------------------------QVMNTSFNPLRIVNTYGAFGSITKERTEVILQGTANPN 193
Cdd:pfam06762 230 VPVCALLRSNKliqsiqlaivtlaavllfalslvpfsvrnllSRMNASFNPLHLVNSYGLFGSMTGGRPEVVIEGSNDGE 309

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661666 194 asapdAVWEDYEFKCKPGDPWRRPCLISPYHYRLDWLMWFAAFQTYEQNEWIIHLTGKLLADDAEALSLLALNPFEGRaP 273
Cdd:pfam06762 310 -----GPWKEYEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPWFLSLLYRLLQNDPEVLGLLDHNPFPDK-P 383

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1958661666 274 PRWIRGEHYRYKFSLPgGQHAAQGKWWIRKRIGPYFP 310
Cdd:pfam06762 384 PKYVRAELYRYRFTTP-GERRATGAWWKRERVGEYFP 419
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 1-310 1.81e-127

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 371.28  E-value: 1.81e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661666   1 MDFHYETQPVPNPMAYYLHRSPRWFHRFETLSNHFLELLVPFFLFLG-RRMCVLHGVLQILFQVVLIISGNLSFLNWLTI 79
Cdd:pfam06762  70 LDYHYETQPLPTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPiRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTI 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661666  80 VPSLACFDDATLGFLFPSGPRGLKKRVLE--------------MQREDAQRVQPKPRYLGCVVRQAANISLGI-LVAWLS 144
Cdd:pfam06762 150 VLSLSLLDDAFLYFWTPESRKKPPRTRLLsvietllsllvyglLIYGTVSLFGLKISENGTFLRRVTLPSIVLgLVSLLS 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661666 145 VPVVINLLSSK-------------------------------QVMNTSFNPLRIVNTYGAFGSITKERTEVILQGTANPN 193
Cdd:pfam06762 230 VPVCALLRSNKliqsiqlaivtlaavllfalslvpfsvrnllSRMNASFNPLHLVNSYGLFGSMTGGRPEVVIEGSNDGE 309

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661666 194 asapdAVWEDYEFKCKPGDPWRRPCLISPYHYRLDWLMWFAAFQTYEQNEWIIHLTGKLLADDAEALSLLALNPFEGRaP 273
Cdd:pfam06762 310 -----GPWKEYEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPWFLSLLYRLLQNDPEVLGLLDHNPFPDK-P 383

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1958661666 274 PRWIRGEHYRYKFSLPgGQHAAQGKWWIRKRIGPYFP 310
Cdd:pfam06762 384 PKYVRAELYRYRFTTP-GERRATGAWWKRERVGEYFP 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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