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Conserved domains on  [gi|1958661023|ref|XP_038942817|]
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large ribosomal subunit protein uL10m isoform X1 [Rattus norvegicus]

Protein Classification

50S ribosomal protein L10( domain architecture ID 10146583)

50S ribosomal protein L10 binds and anchors the two L7/L12 dimers to the large ribosomal subunit

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ribosomal_L10 cd05797
Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and ...
 42-189 2.15e-30

Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein and forms the base of the L7/L12 stalk, while the extended C-terminal helix binds to two or three dimers of the NTD of L7/L12 (L7 and L12 are identical except for an acetylated N-terminus). The L7/L12 stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These bacteria and eukaryotic sequences have no additional C-terminal domain, present in other eukaryotic and archaeal orthologs.


:

Pssm-ID: 240223  Cd Length: 157  Bit Score: 109.90  E-value: 2.15e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661023  42 LLRRDIAAVFRDNRMIAVCQNVALSAEDKLLLRHQLRKHKIFIKVFPSQVLKPFLEDSKYQNLLPLFVGHNLLLVSEEpK 121
Cdd:cd05797     7 EIVAELKEKLKEAKSVVVADYRGLTVAQLTELRKELREAGVKLKVVKNTLAKRALEGTGFEDLDDLLKGPTAIAFSEE-D 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958661023 122 VKEMVRIL----KSVPFLPLLGGCIDDTILSRQGFVEYAKLPSLDRLQGELVGGLTHLTAQTRYLLQHQPVQ 189
Cdd:cd05797    86 PVAAAKVLkdfaKENKKLEIKGGVVEGKVLDAEEVKALAKLPSREELLAQLLGLLQAPATKLVRVLNAPASK 157
 
Name Accession Description Interval E-value
Ribosomal_L10 cd05797
Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and ...
 42-189 2.15e-30

Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein and forms the base of the L7/L12 stalk, while the extended C-terminal helix binds to two or three dimers of the NTD of L7/L12 (L7 and L12 are identical except for an acetylated N-terminus). The L7/L12 stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These bacteria and eukaryotic sequences have no additional C-terminal domain, present in other eukaryotic and archaeal orthologs.


Pssm-ID: 240223  Cd Length: 157  Bit Score: 109.90  E-value: 2.15e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661023  42 LLRRDIAAVFRDNRMIAVCQNVALSAEDKLLLRHQLRKHKIFIKVFPSQVLKPFLEDSKYQNLLPLFVGHNLLLVSEEpK 121
Cdd:cd05797     7 EIVAELKEKLKEAKSVVVADYRGLTVAQLTELRKELREAGVKLKVVKNTLAKRALEGTGFEDLDDLLKGPTAIAFSEE-D 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958661023 122 VKEMVRIL----KSVPFLPLLGGCIDDTILSRQGFVEYAKLPSLDRLQGELVGGLTHLTAQTRYLLQHQPVQ 189
Cdd:cd05797    86 PVAAAKVLkdfaKENKKLEIKGGVVEGKVLDAEEVKALAKLPSREELLAQLLGLLQAPATKLVRVLNAPASK 157
rplJ PRK00099
50S ribosomal protein L10; Reviewed
 46-201 4.77e-13

50S ribosomal protein L10; Reviewed


Pssm-ID: 234632  Cd Length: 172  Bit Score: 64.78  E-value: 4.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661023  46 DIAAVFRDNRMIAVCQNVALSAEDKLLLRHQLRKHKIFIKVFPSQVLKPFLEDSKYQNLLPLFVGHNLLLVSEEPKVkEM 125
Cdd:PRK00099   12 ELAEKLKKAQSAVVADYRGLTVAQMTELRKKLREAGVEYKVVKNTLARRALEGTGFEGLDDLLKGPTAIAFSYEDPV-AA 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661023 126 VRIL----KSVPFLPLLGGCIDDTILSRQGFVEYAKLPSLDRLQGELVGGLTHLTAQTRYLLQHQPVQLTSLLDQYVRQQ 201
Cdd:PRK00099   91 AKVLkdfaKDNKKLEIKGGAIEGKVLDAEEVKALAKLPSREELLAKLLGVLQAPATKLAGVLNAPPSKLARVLKALAEKK 170
RplJ COG0244
Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 ...
 46-201 3.37e-11

Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440014  Cd Length: 172  Bit Score: 59.69  E-value: 3.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661023  46 DIAAVFRDNRMIAVCQNVALSAEDKLLLRHQLRKHKIFIKVFPSQVLKPFLEDSKYQNLLPLFVGHNLLLVS-EEPKV-- 122
Cdd:COG0244    12 ELKEKLKEAQAVVLTDYRGLTVAQMTELRRKLREAGVEYKVVKNTLARIALEGTGFEGLDDLLKGPTAIAFSyEDPVAaa 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958661023 123 KEMVRILKSVPFLPLLGGCIDDTILSRQGFVEYAKLPSLDRLQGELVGGLTHLTAQTRYLLQHQPVQLTSLLDQYVRQQ 201
Cdd:COG0244    92 KVLKDFAKENEKLVIKGGVLDGKVLDAEQVKALAKLPSREELLAKLLGLLQAPATKLVGVLNAPPRKLARVLKAIAEKK 170
Ribosomal_L10 pfam00466
Ribosomal protein L10;
46-131 9.00e-04

Ribosomal protein L10;


Pssm-ID: 459822 [Multi-domain]  Cd Length: 99  Bit Score: 37.52  E-value: 9.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661023  46 DIAAVFRDNRMIAVCQNVALSAEDKLLLRHQLRKHKIFIKVFPSQVLKPFLEDSKYQNLLPLFVGHNLLLVSEEPKVkEM 125
Cdd:pfam00466  12 ELKELLKEYKSVVVVDYRGLTVAQLTELRKKLRENGAELKVGKNTLMRRALEETGEEKLEDYLKGPTALLFTNEDPV-AV 90


                  ....*.
gi 1958661023 126 VRILKS 131
Cdd:pfam00466  91 AKVLED 96
 
Name Accession Description Interval E-value
Ribosomal_L10 cd05797
Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and ...
 42-189 2.15e-30

Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein and forms the base of the L7/L12 stalk, while the extended C-terminal helix binds to two or three dimers of the NTD of L7/L12 (L7 and L12 are identical except for an acetylated N-terminus). The L7/L12 stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These bacteria and eukaryotic sequences have no additional C-terminal domain, present in other eukaryotic and archaeal orthologs.


Pssm-ID: 240223  Cd Length: 157  Bit Score: 109.90  E-value: 2.15e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661023  42 LLRRDIAAVFRDNRMIAVCQNVALSAEDKLLLRHQLRKHKIFIKVFPSQVLKPFLEDSKYQNLLPLFVGHNLLLVSEEpK 121
Cdd:cd05797     7 EIVAELKEKLKEAKSVVVADYRGLTVAQLTELRKELREAGVKLKVVKNTLAKRALEGTGFEDLDDLLKGPTAIAFSEE-D 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958661023 122 VKEMVRIL----KSVPFLPLLGGCIDDTILSRQGFVEYAKLPSLDRLQGELVGGLTHLTAQTRYLLQHQPVQ 189
Cdd:cd05797    86 PVAAAKVLkdfaKENKKLEIKGGVVEGKVLDAEEVKALAKLPSREELLAQLLGLLQAPATKLVRVLNAPASK 157
Ribosomal_L10_P0 cd00379
Ribosomal protein L10 family; composed of the large subunit ribosomal protein called L10 in ...
 42-184 5.22e-24

Ribosomal protein L10 family; composed of the large subunit ribosomal protein called L10 in bacteria, P0 in eukaryotes, and L10e in archaea, as well as uncharacterized P0-like eukaryotic proteins. In all three kingdoms, L10 forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk structure on the large subunit of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein and forms the base of the L7/L12 stalk, while the extended C-terminal helix binds to two or three dimers of the NTD of L7/L12 (L7 and L12 are identical except for an acetylated N-terminus). The L7/L12 stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). Some eukaryotic P0 sequences have an additional C-terminal domain homologous with acidic proteins P1 and P2.


Pssm-ID: 238222 [Multi-domain]  Cd Length: 155  Bit Score: 93.40  E-value: 5.22e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661023  42 LLRRDIAAVFRDNRMIAVCQNVALSAEDKLLLRHQLRKHKIFIKVFPSQVLKPFLEDSKYQNLLPLFVGHNLLLVSEEPK 121
Cdd:cd00379     5 ELVEELKELLKKYKSVVVVDYRGLTVAQLTELRKELRESGAKLKVGKNTLMRRALKGTGFEELKPLLKGPTALAFTNEDP 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958661023 122 VkEMVRIL----KSVPFLPLLGGCIDDTILSRQGFVEYAKLPSLDRLQGELVGGLTHLTAQTRYLLQ 184
Cdd:cd00379    85 V-EVAKVLkdfaKENKKLFAKGGVVAGKVLDPAGVTALAKLPSREELLAMLIGLLKAPIAKLARLLN 150
rplJ PRK00099
50S ribosomal protein L10; Reviewed
 46-201 4.77e-13

50S ribosomal protein L10; Reviewed


Pssm-ID: 234632  Cd Length: 172  Bit Score: 64.78  E-value: 4.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661023  46 DIAAVFRDNRMIAVCQNVALSAEDKLLLRHQLRKHKIFIKVFPSQVLKPFLEDSKYQNLLPLFVGHNLLLVSEEPKVkEM 125
Cdd:PRK00099   12 ELAEKLKKAQSAVVADYRGLTVAQMTELRKKLREAGVEYKVVKNTLARRALEGTGFEGLDDLLKGPTAIAFSYEDPV-AA 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661023 126 VRIL----KSVPFLPLLGGCIDDTILSRQGFVEYAKLPSLDRLQGELVGGLTHLTAQTRYLLQHQPVQLTSLLDQYVRQQ 201
Cdd:PRK00099   91 AKVLkdfaKDNKKLEIKGGAIEGKVLDAEEVKALAKLPSREELLAKLLGVLQAPATKLAGVLNAPPSKLARVLKALAEKK 170
RplJ COG0244
Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 ...
 46-201 3.37e-11

Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440014  Cd Length: 172  Bit Score: 59.69  E-value: 3.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661023  46 DIAAVFRDNRMIAVCQNVALSAEDKLLLRHQLRKHKIFIKVFPSQVLKPFLEDSKYQNLLPLFVGHNLLLVS-EEPKV-- 122
Cdd:COG0244    12 ELKEKLKEAQAVVLTDYRGLTVAQMTELRRKLREAGVEYKVVKNTLARIALEGTGFEGLDDLLKGPTAIAFSyEDPVAaa 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958661023 123 KEMVRILKSVPFLPLLGGCIDDTILSRQGFVEYAKLPSLDRLQGELVGGLTHLTAQTRYLLQHQPVQLTSLLDQYVRQQ 201
Cdd:COG0244    92 KVLKDFAKENEKLVIKGGVLDGKVLDAEQVKALAKLPSREELLAKLLGLLQAPATKLVGVLNAPPRKLARVLKAIAEKK 170
Ribosomal_L10 pfam00466
Ribosomal protein L10;
46-131 9.00e-04

Ribosomal protein L10;


Pssm-ID: 459822 [Multi-domain]  Cd Length: 99  Bit Score: 37.52  E-value: 9.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661023  46 DIAAVFRDNRMIAVCQNVALSAEDKLLLRHQLRKHKIFIKVFPSQVLKPFLEDSKYQNLLPLFVGHNLLLVSEEPKVkEM 125
Cdd:pfam00466  12 ELKELLKEYKSVVVVDYRGLTVAQLTELRKKLRENGAELKVGKNTLMRRALEETGEEKLEDYLKGPTALLFTNEDPV-AV 90


                  ....*.
gi 1958661023 126 VRILKS 131
Cdd:pfam00466  91 AKVLED 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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