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Conserved domains on  [gi|1958660873|ref|XP_038942754|]
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transcription factor E4F1 isoform X5 [Rattus norvegicus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
62-463 5.05e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 5.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660873  62 YVCMLCHKTFKTGSILKAHMVTHSSRKDHEC--KLCGASFRTKGSLIRHHRRHTDERPYKCAKCGKSFRESgaltrhlks 139
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSK--------- 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660873 140 ltPCTEKIRFSISKDTAVGKEEVPAGSSASTVGT----VTSSVAGE---PMETSPVIHLVTDAKGTVIHEVHVQMQELPL 212
Cdd:COG5048   105 --ASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQlpdlLSISNLRNnplPGNNSSSVNTPQSNSLHPPLPANSLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660873 213 GMKALTPESADCEE------LPCSRENSRENLLH-----------QAMQNSGIVLDRVAgEESTLQPAPPSGSSPQSLGD 275
Cdd:COG5048   183 NLSLLISSNVSTSIpsssenSPLSSSYSIPSSSSdqnlensssslPLTTNSQLSPKSLL-SQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660873 276 GPSELPLLEVEQIETQVASEAATVPRT-HPCSQCSETFPSAATLEAHKRG--HIGP--RPFTCT--QCGKAFPKAYLLKK 348
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660873 349 HQEVHVHERRFRC--GDCGKLYKTIAHVRGHRRVH-----SDERPFPC--PQCGKRYKTKNAQQVHFRTHLEEKPHVCQF 419
Cdd:COG5048   342 HILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKN 421

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 1958660873 420 --CSRGFREKGSLVRHVRHHTGEKPFKCYKCGRgFAEHGTLNRHLR 463
Cdd:COG5048   422 ppCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
62-463 5.05e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 5.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660873  62 YVCMLCHKTFKTGSILKAHMVTHSSRKDHEC--KLCGASFRTKGSLIRHHRRHTDERPYKCAKCGKSFRESgaltrhlks 139
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSK--------- 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660873 140 ltPCTEKIRFSISKDTAVGKEEVPAGSSASTVGT----VTSSVAGE---PMETSPVIHLVTDAKGTVIHEVHVQMQELPL 212
Cdd:COG5048   105 --ASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQlpdlLSISNLRNnplPGNNSSSVNTPQSNSLHPPLPANSLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660873 213 GMKALTPESADCEE------LPCSRENSRENLLH-----------QAMQNSGIVLDRVAgEESTLQPAPPSGSSPQSLGD 275
Cdd:COG5048   183 NLSLLISSNVSTSIpsssenSPLSSSYSIPSSSSdqnlensssslPLTTNSQLSPKSLL-SQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660873 276 GPSELPLLEVEQIETQVASEAATVPRT-HPCSQCSETFPSAATLEAHKRG--HIGP--RPFTCT--QCGKAFPKAYLLKK 348
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660873 349 HQEVHVHERRFRC--GDCGKLYKTIAHVRGHRRVH-----SDERPFPC--PQCGKRYKTKNAQQVHFRTHLEEKPHVCQF 419
Cdd:COG5048   342 HILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKN 421

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 1958660873 420 --CSRGFREKGSLVRHVRHHTGEKPFKCYKCGRgFAEHGTLNRHLR 463
Cdd:COG5048   422 ppCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
429-453 5.82e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.82e-05
                          10        20
                  ....*....|....*....|....*
gi 1958660873 429 SLVRHVRHHTGEKPFKCYKCGRGFA 453
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
62-463 5.05e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 5.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660873  62 YVCMLCHKTFKTGSILKAHMVTHSSRKDHEC--KLCGASFRTKGSLIRHHRRHTDERPYKCAKCGKSFRESgaltrhlks 139
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSK--------- 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660873 140 ltPCTEKIRFSISKDTAVGKEEVPAGSSASTVGT----VTSSVAGE---PMETSPVIHLVTDAKGTVIHEVHVQMQELPL 212
Cdd:COG5048   105 --ASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQlpdlLSISNLRNnplPGNNSSSVNTPQSNSLHPPLPANSLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660873 213 GMKALTPESADCEE------LPCSRENSRENLLH-----------QAMQNSGIVLDRVAgEESTLQPAPPSGSSPQSLGD 275
Cdd:COG5048   183 NLSLLISSNVSTSIpsssenSPLSSSYSIPSSSSdqnlensssslPLTTNSQLSPKSLL-SQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660873 276 GPSELPLLEVEQIETQVASEAATVPRT-HPCSQCSETFPSAATLEAHKRG--HIGP--RPFTCT--QCGKAFPKAYLLKK 348
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660873 349 HQEVHVHERRFRC--GDCGKLYKTIAHVRGHRRVH-----SDERPFPC--PQCGKRYKTKNAQQVHFRTHLEEKPHVCQF 419
Cdd:COG5048   342 HILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKN 421

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 1958660873 420 --CSRGFREKGSLVRHVRHHTGEKPFKCYKCGRgFAEHGTLNRHLR 463
Cdd:COG5048   422 ppCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
429-453 5.82e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.82e-05
                          10        20
                  ....*....|....*....|....*
gi 1958660873 429 SLVRHVRHHTGEKPFKCYKCGRGFA 453
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 376-438 1.58e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660873 376 GHRRVHSDERPFPCP--QCGKRYKTKNAQQVHfRTH--------------------LEEKPHVCQFCSRGFREKGSLVRH 433
Cdd:COG5189   339 SRMLKVKDGKPYKCPveGCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ....*
gi 1958660873 434 VRHHT 438
Cdd:COG5189   418 RKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
104-127 2.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.85e-04
                          10        20
                  ....*....|....*....|....
gi 1958660873 104 SLIRHHRRHTDERPYKCAKCGKSF 127
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 231-409 1.22e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660873 231 RENSRENLLHQAMQNSGIVLDRVAGEESTLQP-----------APPSGSSPQSLGD--GPSE---LPLLEVEQIETQVAS 294
Cdd:COG5189   228 RVRSRYIDIGHMMDTHQFYLEDVDLMDDDILGpsneemlykyiSPSQGSAELFEESslGFDYefiHKSVGNKEIRGGIST 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660873 295 EAATVPRTHPCSQCSETFPSAATLEAHKRGH------IGPRPFTC--TQCGKAFPKAYLLKKHQeVHVHERRfrcgdcgK 366
Cdd:COG5189   308 GEMIDVRKLPCTNSSSNGKLAHGGERNIDTPsrmlkvKDGKPYKCpvEGCNKKYKNQNGLKYHM-LHGHQNQ-------K 379

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1958660873 367 LYKTIAHVRgHRRVHSDERPFPCPQCGKRYKTKNAQQVHfRTH 409
Cdd:COG5189   380 LHENPSPEK-MNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKH 420
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 304-390 1.24e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.55  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660873 304 PCSQ--CSETFPSAATLEAHKRGHIGP------RPFTCT--QCGKAFPKAYLLKKHQEVHVHERR-FRCGDCGKLYKTIA 372
Cdd:pfam15909   1 PCSSpgCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSalSCTETFPSMQELVAHSKLHYKPNRyFKCENCLLRFRTHR 80

                          90
                  ....*....|....*...
gi 1958660873 373 HVRGHRRVHSDERPFPCP 390
Cdd:pfam15909  81 SLFKHLHVCAEHAQSPAP 98
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 90-112 1.58e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.58e-03
                          10        20
                  ....*....|....*....|...
gi 1958660873  90 HECKLCGASFRTKGSLIRHHRRH 112
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-340 3.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.66e-03
                          10        20
                  ....*....|....*....|...
gi 1958660873 318 LEAHKRGHIGPRPFTCTQCGKAF 340
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
373-398 3.88e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.88e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958660873 373 HVRGHRRVHSDERPFPCPQCGKRYKT 398
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 331-353 5.29e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.29e-03
                          10        20
                  ....*....|....*....|...
gi 1958660873 331 FTCTQCGKAFPKAYLLKKHQEVH 353
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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