tubulin gamma-2 chain isoform X1 [Rattus norvegicus]
Protein Classification
tubulin gamma chain( domain architecture ID 10115134)
tubulin gamma chain recruits the alpha/beta-tubulin dimers that form the minus ends of microtubules and is thought to be involved in microtubule nucleation and capping
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| gamma_tubulin | cd02188 | The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of ... |
37-361 | 0e+00 | ||||||
The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of tubulin superfamily. Gamma is a low abundance protein present within the cells in both various types of microtubule-organizing centers and cytoplasmic protein complexes. Gamma-tubulin recruits the alpha/beta-tubulin dimers that form the minus ends of microtubules and is thought to be involved in microtubule nucleation and capping. : Pssm-ID: 276957 [Multi-domain] Cd Length: 430 Bit Score: 687.74 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | ||||||
| gamma_tubulin | cd02188 | The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of ... |
37-361 | 0e+00 | ||||||
The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of tubulin superfamily. Gamma is a low abundance protein present within the cells in both various types of microtubule-organizing centers and cytoplasmic protein complexes. Gamma-tubulin recruits the alpha/beta-tubulin dimers that form the minus ends of microtubules and is thought to be involved in microtubule nucleation and capping. Pssm-ID: 276957 [Multi-domain] Cd Length: 430 Bit Score: 687.74 E-value: 0e+00
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| PLN00222 | PLN00222 | tubulin gamma chain; Provisional |
37-377 | 0e+00 | ||||||
tubulin gamma chain; Provisional Pssm-ID: 215108 [Multi-domain] Cd Length: 454 Bit Score: 631.88 E-value: 0e+00
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| Tubulin_C | pfam03953 | Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. ... |
190-318 | 3.87e-65 | ||||||
Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family). Pssm-ID: 397858 [Multi-domain] Cd Length: 125 Bit Score: 202.85 E-value: 3.87e-65
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| Tubulin | smart00864 | Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the ... |
37-173 | 3.19e-45 | ||||||
Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the bacterial FtsZ family of proteins. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea. Pssm-ID: 214867 [Multi-domain] Cd Length: 192 Bit Score: 153.80 E-value: 3.19e-45
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| Name | Accession | Description | Interval | E-value | ||||||
| gamma_tubulin | cd02188 | The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of ... |
37-361 | 0e+00 | ||||||
The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of tubulin superfamily. Gamma is a low abundance protein present within the cells in both various types of microtubule-organizing centers and cytoplasmic protein complexes. Gamma-tubulin recruits the alpha/beta-tubulin dimers that form the minus ends of microtubules and is thought to be involved in microtubule nucleation and capping. Pssm-ID: 276957 [Multi-domain] Cd Length: 430 Bit Score: 687.74 E-value: 0e+00
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| PLN00222 | PLN00222 | tubulin gamma chain; Provisional |
37-377 | 0e+00 | ||||||
tubulin gamma chain; Provisional Pssm-ID: 215108 [Multi-domain] Cd Length: 454 Bit Score: 631.88 E-value: 0e+00
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| Tubulin | cd06059 | The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct ... |
37-361 | 1.17e-117 | ||||||
The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins. Also included in this group is the mitochondrial Misato/DML1 protein family, involved in mitochondrial fusion and in mitochondrial distribution and morphology. Pssm-ID: 276963 [Multi-domain] Cd Length: 387 Bit Score: 346.50 E-value: 1.17e-117
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| Tubulin_FtsZ_Cetz-like | cd00286 | Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, ... |
36-307 | 1.99e-110 | ||||||
Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, gamma-, delta-, epsilon, and zeta-tubulins as well as FtsZ and CetZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved oligomer. Microtubules exist in all eukaryotic cells and are responsible for many functions, including cellular transport, cell motility, and mitosis. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria, archaea, and chloroplasts. A recent study found that CetZ proteins, formerly annotated FtsZ type 2, are not required for cell division, whereas FtsZ proteins play an important role. Instead, CetZ proteins are shown to be involved in controlling archaeal cell shape dynamics. The results from inactivation studies of CetZ proteins in Haloferax volcanii suggest that CetZ1 is essential for normal swimming motility and rod-cell development. Pssm-ID: 276954 [Multi-domain] Cd Length: 332 Bit Score: 326.29 E-value: 1.99e-110
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| beta_tubulin | cd02187 | The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ... |
37-361 | 5.05e-94 | ||||||
The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins. Pssm-ID: 276956 [Multi-domain] Cd Length: 425 Bit Score: 287.54 E-value: 5.05e-94
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| alpha_tubulin | cd02186 | The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ... |
36-363 | 1.23e-81 | ||||||
The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins. Pssm-ID: 276955 [Multi-domain] Cd Length: 434 Bit Score: 255.93 E-value: 1.23e-81
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| PTZ00010 | PTZ00010 | tubulin beta chain; Provisional |
36-361 | 4.77e-71 | ||||||
tubulin beta chain; Provisional Pssm-ID: 240228 [Multi-domain] Cd Length: 445 Bit Score: 228.89 E-value: 4.77e-71
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| Tubulin_C | pfam03953 | Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. ... |
190-318 | 3.87e-65 | ||||||
Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family). Pssm-ID: 397858 [Multi-domain] Cd Length: 125 Bit Score: 202.85 E-value: 3.87e-65
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| PLN00220 | PLN00220 | tubulin beta chain; Provisional |
37-361 | 1.83e-64 | ||||||
tubulin beta chain; Provisional Pssm-ID: 215107 [Multi-domain] Cd Length: 447 Bit Score: 211.99 E-value: 1.83e-64
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| epsilon_tubulin | cd02190 | The epsilon-tubulin family; The tubulin superfamily includes five distinct families, the ... |
37-363 | 7.34e-62 | ||||||
The epsilon-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The epsilon-tubulins which are widespread but not ubiquitous among eukaryotes play a role in basal body/centriole morphogenesis. Pssm-ID: 276959 [Multi-domain] Cd Length: 449 Bit Score: 205.17 E-value: 7.34e-62
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| PTZ00335 | PTZ00335 | tubulin alpha chain; Provisional |
36-361 | 2.23e-60 | ||||||
tubulin alpha chain; Provisional Pssm-ID: 185562 [Multi-domain] Cd Length: 448 Bit Score: 201.09 E-value: 2.23e-60
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| PTZ00387 | PTZ00387 | epsilon tubulin; Provisional |
37-361 | 3.20e-59 | ||||||
epsilon tubulin; Provisional Pssm-ID: 240395 [Multi-domain] Cd Length: 465 Bit Score: 198.79 E-value: 3.20e-59
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| PLN00221 | PLN00221 | tubulin alpha chain; Provisional |
36-361 | 6.12e-51 | ||||||
tubulin alpha chain; Provisional Pssm-ID: 177802 Cd Length: 450 Bit Score: 176.54 E-value: 6.12e-51
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| delta_zeta_tubulin-like | cd02189 | The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, ... |
36-363 | 1.16e-47 | ||||||
The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. Delta-tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies. Pssm-ID: 276958 [Multi-domain] Cd Length: 433 Bit Score: 167.44 E-value: 1.16e-47
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| Tubulin | smart00864 | Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the ... |
37-173 | 3.19e-45 | ||||||
Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the bacterial FtsZ family of proteins. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea. Pssm-ID: 214867 [Multi-domain] Cd Length: 192 Bit Score: 153.80 E-value: 3.19e-45
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| Tubulin | pfam00091 | Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma ... |
36-140 | 1.60e-41 | ||||||
Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. Pssm-ID: 459669 [Multi-domain] Cd Length: 190 Bit Score: 144.28 E-value: 1.60e-41
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| Tubulin_C | smart00865 | Tubulin/FtsZ family, C-terminal domain; This domain is found in the tubulin alpha, beta and ... |
175-315 | 3.23e-18 | ||||||
Tubulin/FtsZ family, C-terminal domain; This domain is found in the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. These proteins are GTPases and are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea. This is the C-terminal domain. Pssm-ID: 214868 [Multi-domain] Cd Length: 120 Bit Score: 79.52 E-value: 3.23e-18
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| CetZ_tubulin-like | cd02202 | Cell-structure-related euryarchaeota tubulin/FtsZ homologs; CetZ proteins comprise a distinct ... |
38-142 | 2.24e-08 | ||||||
Cell-structure-related euryarchaeota tubulin/FtsZ homologs; CetZ proteins comprise a distinct tubulin/FtsZ family. The crystal structures of CetZ contain the FtsZ/tubulin superfamily fold and its family members have mosaic of tubulin-like and FtsZ-like amino acid residues. However, a recent study found that CetZ proteins (formerly annotated FtsZ type 2) are not required for cell division, whereas FtsZ proteins play an important role. Instead, CetZ proteins are shown to be involved in controlling archaeal cell shape dynamics. The results from inactivation studies of CetZ proteins in Haloferax volcanii suggest that CetZ1 is essential for normal swimming motility and rod-cell development. Pssm-ID: 276962 [Multi-domain] Cd Length: 357 Bit Score: 55.33 E-value: 2.24e-08
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| FtsZ_CetZ-like | cd02191 | Subfamily of FitZ and Cell-structure-related euryarchaeota tubulin/FtsZ homolog-like; FtsZ is ... |
23-261 | 3.48e-06 | ||||||
Subfamily of FitZ and Cell-structure-related euryarchaeota tubulin/FtsZ homolog-like; FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. CetZ-like proteins are related to tubulin and FtsZ and co-exists with FtsZ in many archaea. However, a recent study found that Cetz proteins (formerly annotated FtsZ type 2) are not required for cell division. Instead, CetZ proteins are shown to be involved in controlling archaeal cell shape dynamics. The results from inactivation studies of CetZ proteins in Haloferax volcanii suggest that CetZ1 is essential for normal swimming motility and rod-cell development. Pssm-ID: 276960 [Multi-domain] Cd Length: 308 Bit Score: 48.33 E-value: 3.48e-06
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| misato | cd06060 | Misato segment II tubulin-like domain; Human Misato shows similarity with Tubulin/FtsZ family ... |
56-171 | 6.15e-06 | ||||||
Misato segment II tubulin-like domain; Human Misato shows similarity with Tubulin/FtsZ family of GTPases and is localized to the the outer membrane of mitochondria. It has a role in mitochondrial fusion and in mitochondrial distribution and morphology. Mutations in its Drosophila homolog (misato) lead to irregular chromosome segregation during mitosis. Deletion of the budding yeast homolog DML1 is lethal and unregulate expression of DML1 leads to mitochondrial dispersion and abnormalities in cell morphology. The Misato/DML1 protein family is conserved from yeast to human, but its exact function is still unknown. Pssm-ID: 276964 [Multi-domain] Cd Length: 539 Bit Score: 48.08 E-value: 6.15e-06
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| FtsZ_type1 | cd02201 | Filamenting temperature sensitive mutant Z, type 1; FtsZ is a GTPase that is similar to the ... |
118-179 | 5.19e-03 | ||||||
Filamenting temperature sensitive mutant Z, type 1; FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. Pssm-ID: 276961 [Multi-domain] Cd Length: 303 Bit Score: 38.53 E-value: 5.19e-03
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| Blast search parameters | ||||
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