NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958660551|ref|XP_038942621|]
View 

nuclear receptor corepressor 1 isoform X20 [Rattus norvegicus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GPS2_interact super family cl24372
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 162-251 1.89e-27

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


The actual alignment was detected with superfamily member pfam15784:

Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 108.02  E-value: 1.89e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551  162 FGGKHEAPSSPLAGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 241
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1958660551  242 EQKHRSIVQI 251
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 649-692 6.41e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.41e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958660551  649 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 692
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
LGT super family cl00478
Prolipoprotein diacylglyceryl transferase;
750-916 3.67e-05

Prolipoprotein diacylglyceryl transferase;


The actual alignment was detected with superfamily member PRK13108:

Pssm-ID: 469786 [Multi-domain]  Cd Length: 460  Bit Score: 48.82  E-value: 3.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551  750 VEAAKSSEDSsenAASRGN---TEPVAELEATTDPAPC-ASPSSAVPTTKPAESESVEAqVTDSASVETAEPMDVDHEEC 825
Cdd:PRK13108   273 ILAPKGREAP---GALRGSeyvVDEALEREPAELAAAAvASAASAVGPVGPGEPNQPDD-VAEAVKAEVAEVTDEVAAES 348

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551  826 GAQGSSVLDPPAPTKADSVDPEIQVPENTASKGEGDAKDR---------DLESASEKTEARDEDLVVAEQMQRPEPQSDN 896
Cdd:PRK13108   349 VVQVADRDGESTPAVEETSEADIEREQPGDLAGQAPAAHQvdaeaasaaPEEPAALASEAHDETEPEVPEKAAPIPDPAK 428

                          170       180
                   ....*....|....*....|
gi 1958660551  897 DSSATCSADEDVDGEPERQR 916
Cdd:PRK13108   429 PDELAVAGPGDDPAEPDGIR 448
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 462-504 1.32e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


:

Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.32e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958660551  462 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 504
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
PRK10263 super family cl35903
DNA translocase FtsK; Provisional
 2066-2251 2.26e-03

DNA translocase FtsK; Provisional


The actual alignment was detected with superfamily member PRK10263:

Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.54  E-value: 2.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551 2066 YEAPSDAIEVISPASSPAPPQEKPQ-AYQP-------EMVKANQAENESPQ-QYEGPLHHYRSQQGSPSPQQQPPLPPSS 2136
Cdd:PRK10263   333 WAAPVEPVTQTPPVASVDVPPAQPTvAWQPvpgpqtgEPVIAPAPEGYPQQsQYAQPAVQYNEPLQQPVQPQQPYYAPAA 412

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551 2137 QAEGMGQVPRTHRLITLA-DHICQIITQDFARNQVPSQPSTSTFQTSPSALSSTPVrTKPSSRYSPESQSQTVlhpRPGP 2215
Cdd:PRK10263   413 EQPAQQPYYAPAPEQPAQqPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTY-QQPAAQEPLYQQPQPV---EQQP 488

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1958660551 2216 RVSPENLVDKSRGSRP----------GKSPERSHIPSEpYEPISPP 2251
Cdd:PRK10263   489 VVEPEPVVEETKPARPplyyfeeveeKRAREREQLAAW-YQPIPEP 533
 
Name Accession Description Interval E-value
GPS2_interact pfam15784
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 162-251 1.89e-27

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 108.02  E-value: 1.89e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551  162 FGGKHEAPSSPLAGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 241
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1958660551  242 EQKHRSIVQI 251
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 649-692 6.41e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.41e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958660551  649 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 692
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 649-692 1.39e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 58.36  E-value: 1.39e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958660551  649 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYK 692
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
649-694 2.21e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 58.00  E-value: 2.21e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1958660551   649 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYKRR 694
Cdd:smart00717    3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 750-916 3.67e-05

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 48.82  E-value: 3.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551  750 VEAAKSSEDSsenAASRGN---TEPVAELEATTDPAPC-ASPSSAVPTTKPAESESVEAqVTDSASVETAEPMDVDHEEC 825
Cdd:PRK13108   273 ILAPKGREAP---GALRGSeyvVDEALEREPAELAAAAvASAASAVGPVGPGEPNQPDD-VAEAVKAEVAEVTDEVAAES 348

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551  826 GAQGSSVLDPPAPTKADSVDPEIQVPENTASKGEGDAKDR---------DLESASEKTEARDEDLVVAEQMQRPEPQSDN 896
Cdd:PRK13108   349 VVQVADRDGESTPAVEETSEADIEREQPGDLAGQAPAAHQvdaeaasaaPEEPAALASEAHDETEPEVPEKAAPIPDPAK 428

                          170       180
                   ....*....|....*....|
gi 1958660551  897 DSSATCSADEDVDGEPERQR 916
Cdd:PRK13108   429 PDELAVAGPGDDPAEPDGIR 448
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 729-913 9.54e-05

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 48.09  E-value: 9.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551  729 SAQEDEDIEASNEEENPEDSEVEAAKSSEDSSENAASRGNTEPVAELEATTDpapcaspsSAVPTTKPAESESVEaqvTD 808
Cdd:COG5271    645 SEAADEDADAETEAEASADESEEEAEDESETSSEDAEEDADAAAAEASDDEE--------ETEEADEDAETASEE---AD 713

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551  809 SASVETAEPMDVDHEECGAQGSSVLDPPA---PTKADSVDPEIQVPENTASKGEGDAKDRDLESASEKTEARDEDLVVAE 885
Cdd:COG5271    714 AEEADTEADGTAEEAEEAAEEAESADEEAaslPDEADAEEEAEEAEEAEEDDADGLEEALEEEKADAEEAATDEEAEAAA 793

                          170       180
                   ....*....|....*....|....*...
gi 1958660551  886 qmqrPEPQSDNDSSATCSADEDVDGEPE 913
Cdd:COG5271    794 ----EEKEKVADEDQDTDEDALLDEAEA 817
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 462-504 1.32e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.32e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958660551  462 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 504
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
460-505 4.09e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 40.28  E-value: 4.09e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1958660551   460 NVWTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTKK 505
Cdd:smart00717    2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLK 48
AIF-MLS pfam14962
Mitochondria localization Sequence; This family contains a protein found in eukaryotes. ...
 741-845 5.17e-04

Mitochondria localization Sequence; This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localization sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.


Pssm-ID: 464407 [Multi-domain]  Cd Length: 192  Bit Score: 43.66  E-value: 5.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551  741 EEENPEDSEVEAAKSSEDSSENAASRGNTE-PVAELEATTDPAPCASPSSAVPTTKPAESESVEAQVTDSASVETAepmd 819
Cdd:pfam14962   95 EKENVAEAEKASSEAPEVSVVEAEVVDAEEiPDATAAVIEEASACPGDVEAAPVETTAVGAETGPEVTDAATGETT---- 170

                           90       100
                   ....*....|....*....|....*.
gi 1958660551  820 vdheECGAQGSSVLDPPAPTKADSVD 845
Cdd:pfam14962  171 ----EVSAETTPEVTSAAPDEAVAID 192
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 462-501 5.43e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 39.79  E-value: 5.43e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958660551  462 WTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYY 501
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 2066-2251 2.26e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.54  E-value: 2.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551 2066 YEAPSDAIEVISPASSPAPPQEKPQ-AYQP-------EMVKANQAENESPQ-QYEGPLHHYRSQQGSPSPQQQPPLPPSS 2136
Cdd:PRK10263   333 WAAPVEPVTQTPPVASVDVPPAQPTvAWQPvpgpqtgEPVIAPAPEGYPQQsQYAQPAVQYNEPLQQPVQPQQPYYAPAA 412

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551 2137 QAEGMGQVPRTHRLITLA-DHICQIITQDFARNQVPSQPSTSTFQTSPSALSSTPVrTKPSSRYSPESQSQTVlhpRPGP 2215
Cdd:PRK10263   413 EQPAQQPYYAPAPEQPAQqPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTY-QQPAAQEPLYQQPQPV---EQQP 488

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1958660551 2216 RVSPENLVDKSRGSRP----------GKSPERSHIPSEpYEPISPP 2251
Cdd:PRK10263   489 VVEPEPVVEETKPARPplyyfeeveeKRAREREQLAAW-YQPIPEP 533
 
Name Accession Description Interval E-value
GPS2_interact pfam15784
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 162-251 1.89e-27

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 108.02  E-value: 1.89e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551  162 FGGKHEAPSSPLAGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 241
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1958660551  242 EQKHRSIVQI 251
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 649-692 6.41e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.41e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958660551  649 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 692
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 649-692 1.39e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 58.36  E-value: 1.39e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958660551  649 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYK 692
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
649-694 2.21e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 58.00  E-value: 2.21e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1958660551   649 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYKRR 694
Cdd:smart00717    3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 750-916 3.67e-05

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 48.82  E-value: 3.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551  750 VEAAKSSEDSsenAASRGN---TEPVAELEATTDPAPC-ASPSSAVPTTKPAESESVEAqVTDSASVETAEPMDVDHEEC 825
Cdd:PRK13108   273 ILAPKGREAP---GALRGSeyvVDEALEREPAELAAAAvASAASAVGPVGPGEPNQPDD-VAEAVKAEVAEVTDEVAAES 348

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551  826 GAQGSSVLDPPAPTKADSVDPEIQVPENTASKGEGDAKDR---------DLESASEKTEARDEDLVVAEQMQRPEPQSDN 896
Cdd:PRK13108   349 VVQVADRDGESTPAVEETSEADIEREQPGDLAGQAPAAHQvdaeaasaaPEEPAALASEAHDETEPEVPEKAAPIPDPAK 428

                          170       180
                   ....*....|....*....|
gi 1958660551  897 DSSATCSADEDVDGEPERQR 916
Cdd:PRK13108   429 PDELAVAGPGDDPAEPDGIR 448
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 729-913 9.54e-05

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 48.09  E-value: 9.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551  729 SAQEDEDIEASNEEENPEDSEVEAAKSSEDSSENAASRGNTEPVAELEATTDpapcaspsSAVPTTKPAESESVEaqvTD 808
Cdd:COG5271    645 SEAADEDADAETEAEASADESEEEAEDESETSSEDAEEDADAAAAEASDDEE--------ETEEADEDAETASEE---AD 713

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551  809 SASVETAEPMDVDHEECGAQGSSVLDPPA---PTKADSVDPEIQVPENTASKGEGDAKDRDLESASEKTEARDEDLVVAE 885
Cdd:COG5271    714 AEEADTEADGTAEEAEEAAEEAESADEEAaslPDEADAEEEAEEAEEAEEDDADGLEEALEEEKADAEEAATDEEAEAAA 793

                          170       180
                   ....*....|....*....|....*...
gi 1958660551  886 qmqrPEPQSDNDSSATCSADEDVDGEPE 913
Cdd:COG5271    794 ----EEKEKVADEDQDTDEDALLDEAEA 817
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 462-504 1.32e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.32e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958660551  462 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 504
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 696-913 1.64e-04

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 47.32  E-value: 1.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551  696 NLDNLLQQHKQKASRKPREERDVSQCESVASTVSAQEDED---IEASNEEENPEDSEVEAAKSSEDSSENAASRGNTEPV 772
Cdd:COG5271    548 GSDQDADETDEPEATAEEDEPDEAEAETEDATENADADETeesADESEEAEASEDEAAEEEEADDDEADADADGAADEEE 627

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551  773 AELEATTDPAPCASPSSAVPTTKPAESESVEAQVTDSASVETAEPMDV-----DHEECGAQGSSVLDPPAPTKADSvDPE 847
Cdd:COG5271    628 TEEEAAEDEAAEPETDASEAADEDADAETEAEASADESEEEAEDESETssedaEEDADAAAAEASDDEEETEEADE-DAE 706

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958660551  848 IQVPENTASKGEGDAKDRDLESASEKTEARDEDLVVAEQMQRPEPQSDNDSSATcSADEDVDGEPE 913
Cdd:COG5271    707 TASEEADAEEADTEADGTAEEAEEAAEEAESADEEAASLPDEADAEEEAEEAEE-AEEDDADGLEE 771
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
460-505 4.09e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 40.28  E-value: 4.09e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1958660551   460 NVWTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTKK 505
Cdd:smart00717    2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLK 48
AIF-MLS pfam14962
Mitochondria localization Sequence; This family contains a protein found in eukaryotes. ...
 741-845 5.17e-04

Mitochondria localization Sequence; This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localization sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.


Pssm-ID: 464407 [Multi-domain]  Cd Length: 192  Bit Score: 43.66  E-value: 5.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551  741 EEENPEDSEVEAAKSSEDSSENAASRGNTE-PVAELEATTDPAPCASPSSAVPTTKPAESESVEAQVTDSASVETAepmd 819
Cdd:pfam14962   95 EKENVAEAEKASSEAPEVSVVEAEVVDAEEiPDATAAVIEEASACPGDVEAAPVETTAVGAETGPEVTDAATGETT---- 170

                           90       100
                   ....*....|....*....|....*.
gi 1958660551  820 vdheECGAQGSSVLDPPAPTKADSVD 845
Cdd:pfam14962  171 ----EVSAETTPEVTSAAPDEAVAID 192
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 462-501 5.43e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 39.79  E-value: 5.43e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958660551  462 WTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYY 501
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 462-505 1.00e-03

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 39.13  E-value: 1.00e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958660551  462 WTDHEKEIFKDKFIQHPKNFGLI-ASYLERKSVPDCVLYYYLTKK 505
Cdd:cd11661      2 WSESEAKLFEEGLRKYGKDFHDIrQDFLPWKSVGELVEFYYMWKK 46
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 702-913 1.72e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 43.85  E-value: 1.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551  702 QQHKQKASRKPREERDvSQCESVASTVSAQEDEDIEASNEEENPEDSEVEAAKSSEDSSENAASRGNTEPVAELEATTDP 781
Cdd:COG5271    431 DESTDVTSAEDDIATD-EEADSLADEEEEAEAELDTEEDTESAEEDADGDEATDEDDASDDGDEEEAEEDAEAEADSDEL 509

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551  782 APCASPSSAVPTTKPAES--ESVEAQVTDSASVETAEP-MDVDHEEcgaqgssVLDPPAPTKADSVDPEIQVPENTASKG 858
Cdd:COG5271    510 TAEETSADDGADTDAAADpeDSDEDALEDETEGEENAPgSDQDADE-------TDEPEATAEEDEPDEAEAETEDATENA 582

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958660551  859 EGDAKDRDLESASEKTEARDEDlvvAEQMQRPEPQSDNDSSATcsADEDVDGEPE 913
Cdd:COG5271    583 DADETEESADESEEAEASEDEA---AEEEEADDDEADADADGA--ADEEETEEEA 632
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 2066-2251 2.26e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.54  E-value: 2.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551 2066 YEAPSDAIEVISPASSPAPPQEKPQ-AYQP-------EMVKANQAENESPQ-QYEGPLHHYRSQQGSPSPQQQPPLPPSS 2136
Cdd:PRK10263   333 WAAPVEPVTQTPPVASVDVPPAQPTvAWQPvpgpqtgEPVIAPAPEGYPQQsQYAQPAVQYNEPLQQPVQPQQPYYAPAA 412

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660551 2137 QAEGMGQVPRTHRLITLA-DHICQIITQDFARNQVPSQPSTSTFQTSPSALSSTPVrTKPSSRYSPESQSQTVlhpRPGP 2215
Cdd:PRK10263   413 EQPAQQPYYAPAPEQPAQqPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTY-QQPAAQEPLYQQPQPV---EQQP 488

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1958660551 2216 RVSPENLVDKSRGSRP----------GKSPERSHIPSEpYEPISPP 2251
Cdd:PRK10263   489 VVEPEPVVEETKPARPplyyfeeveeKRAREREQLAAW-YQPIPEP 533
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 650-697 2.81e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 38.06  E-value: 2.81e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1958660551  650 WTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKnFYFNYKRRHNL 697
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCF-DRWRRKLNPKI 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH