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Conserved domains on  [gi|1958659220|ref|XP_038942145|]
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solute carrier family 38 member 10 isoform X10 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
6-320 1.29e-30

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member pfam01490:

Pssm-ID: 444915  Cd Length: 410  Bit Score: 125.88  E-value: 1.29e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220    6 TSKWGLVTNVVNSIVGVSVLTMPFCFKQCGIVLGALLLVFCSWMTHQSCMFLVKSA-----SLSKRRTYAGLAFHAYGKA 80
Cdd:pfam01490    3 ISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCSkevpvTGKRNKSYGDLGYRLLGPK 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220   81 GKMLVETSMIGLMLGSCITFYVVIGDLGSNFFAPLLGlqvTRTFRVFLLFAVSLCIVLPLSLQRNMMA-SIqsFSAMALL 159
Cdd:pfam01490   83 GRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFD---TCPISLVYFIIIFGLIFIPLSFIPNLSAlSI--LSLLAAV 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  160 FYTVFMFVIVLSSFKHGLFSGQ---WLQRVSYIRWEGVFRCVPIFGMSFACQSQVLPTYDSLDEPSV-KTMSSIFASSLN 235
Cdd:pfam01490  158 SSLYYIVILVLSVAEGIVLTAQgvgHLGSKTNIKLAGTFLAIGIIVFAFEGHAVLLPIQNEMKNPSKfKAMTKILLTAII 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  236 VVTAFYV----------------------------------------------------------MQKDGTFAAGGYMPP 257
Cdd:pfam01490  238 IATVLYIliglvgylafgdnvkgnillnlpksawlidianlllvlhvilsfplqlfpirqivenlLFRKEAPFGASGKNN 317
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958659220  258 ----LRFKVLTLSVVFGTMVGGVMIPNVETILGFTGATMGSLICFICPALIYKKAHKNAPSAQVVLW 320
Cdd:pfam01490  318 pkskLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLKLKKTKKKSQEKLW 384
PTZ00121 super family cl31754
MAEBL; Provisional
335-1024 5.05e-08

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.46  E-value: 5.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  335 SVSEEAPLDLTQGARSGQRGDAEGAMKVEAARLSVQDPVVVMA---EDSQ--EKLKPAEDKEVLEQA----QIKGPVDVP 405
Cdd:PTZ00121  1115 RKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIArkaEDARkaEEARKAEDAKKAEAArkaeEVRKAEELR 1194
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  406 GGDTPKEKQEAAQLDRPGQGIAVPMGE-AHRHEPPIPHDKVVVDEGQDQEGPEEKKPPPKLPDEGDPA---GRGQGAPLL 481
Cdd:PTZ00121  1195 KAEDARKAEAARKAEEERKAEEARKAEdAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMahfARRQAAIKA 1274
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  482 PESEKKQDPERGEEGKRPEQVLAVGEI----ERPQKIPEANGQPPVQPRKEDSRPGNRDLHPVPQ-----ARVSVELNDL 552
Cdd:PTZ00121  1275 EEARKADELKKAEEKKKADEAKKAEEKkkadEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEeakkaAEAAKAEAEA 1354
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  553 VAGEGKESAQKAGGAPWKPMESAVESNIGGKAGLAVQRPE-----------AAEQREKNEAEQPGGDQAGSKLEA----- 616
Cdd:PTZ00121  1355 AADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADeakkkaeedkkKADELKKAAAAKKKADEAKKKAEEkkkad 1434
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  617 EIKKLVAEAGRAEMLDHAVLLQVIKE---QQVQQKRLLDQQEKLlaviEEQHKEIRQQRQEGEEDKPKPADM----QPEP 689
Cdd:PTZ00121  1435 EAKKKAEEAKKADEAKKKAEEAKKAEeakKKAEEAKKADEAKKK----AEEAKKADEAKKKAEEAKKKADEAkkaaEAKK 1510
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  690 GAAVLRGQEE--EAEHAGAPDE--HAGETLEDNPSQPLQPVLGAPRGHPAPSQDKGQHP--LEEVKVLAGRDLADL---- 759
Cdd:PTZ00121  1511 KADEAKKAEEakKADEAKKAEEakKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAkkAEEDKNMALRKAEEAkkae 1590
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  760 ------PAGGSDTEPHGASSKLREDQ----KGAALKVAEAVRKLVpgdlEPVHKPDPAEVPKSPEKQLAKEVARQRQDVF 829
Cdd:PTZ00121  1591 earieeVMKLYEEEKKMKAEEAKKAEeakiKAEELKKAEEEKKKV----EQLKKKEAEEKKKAEELKKAEEENKIKAAEE 1666
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  830 GEGSQERKETGKDAVAPGADTQKEAAQPLVGAEAEDSHSKSRHSEPTKVpasgpagmgfQAQARFRQEPQVIFDKSQDSH 909
Cdd:PTZ00121  1667 AKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEK----------KKAEELKKAEEENKIKAEEAK 1736
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  910 PEVRSEGPRGVGIPAEEQHRGRGAAAMQEEKQRPDPNSGPKLAVPG---DQKPENAKPNRDLKVqagsdlrrrrrdlasp 986
Cdd:PTZ00121  1737 KEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEeelDEEDEKRRMEVDKKI---------------- 1800
                          730       740       750
                   ....*....|....*....|....*....|....*...
gi 1958659220  987 peQELAPKDGVIISFNSLPNVQVNDLRSALDTQLRQAA 1024
Cdd:PTZ00121  1801 --KDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVA 1836
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
6-320 1.29e-30

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 125.88  E-value: 1.29e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220    6 TSKWGLVTNVVNSIVGVSVLTMPFCFKQCGIVLGALLLVFCSWMTHQSCMFLVKSA-----SLSKRRTYAGLAFHAYGKA 80
Cdd:pfam01490    3 ISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCSkevpvTGKRNKSYGDLGYRLLGPK 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220   81 GKMLVETSMIGLMLGSCITFYVVIGDLGSNFFAPLLGlqvTRTFRVFLLFAVSLCIVLPLSLQRNMMA-SIqsFSAMALL 159
Cdd:pfam01490   83 GRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFD---TCPISLVYFIIIFGLIFIPLSFIPNLSAlSI--LSLLAAV 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  160 FYTVFMFVIVLSSFKHGLFSGQ---WLQRVSYIRWEGVFRCVPIFGMSFACQSQVLPTYDSLDEPSV-KTMSSIFASSLN 235
Cdd:pfam01490  158 SSLYYIVILVLSVAEGIVLTAQgvgHLGSKTNIKLAGTFLAIGIIVFAFEGHAVLLPIQNEMKNPSKfKAMTKILLTAII 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  236 VVTAFYV----------------------------------------------------------MQKDGTFAAGGYMPP 257
Cdd:pfam01490  238 IATVLYIliglvgylafgdnvkgnillnlpksawlidianlllvlhvilsfplqlfpirqivenlLFRKEAPFGASGKNN 317
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958659220  258 ----LRFKVLTLSVVFGTMVGGVMIPNVETILGFTGATMGSLICFICPALIYKKAHKNAPSAQVVLW 320
Cdd:pfam01490  318 pkskLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLKLKKTKKKSQEKLW 384
PTZ00206 PTZ00206
amino acid transporter; Provisional
14-305 7.34e-11

amino acid transporter; Provisional


Pssm-ID: 240313  Cd Length: 467  Bit Score: 65.66  E-value: 7.34e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220   14 NVVNSIVGVSVLTMPFCFKQCGIVLGALLLVFCSWMTHQSCMFLVKSASLSKRRTYAGLAFHAYGKAGKMLVETSMIGLM 93
Cdd:PTZ00206    68 NIASSTVGAGIVGLPSAANSSGLVMAMIYLIIITAMTIFSIYALGVAADKTNIRTYEGVARVLLGPWGSYYVAATRAFHG 147
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220   94 LGSCITFYVVIGDLGSnffAPLLGLQV-----TRTFRVFLLFAVSLCIVLPLSLQRNmMASIQSFSAMALLFYTVFMFVI 168
Cdd:PTZ00206   148 FSACVAYVISVGDILS---ATLKGTNApdflkQKSGNRLLTSLMWLCFMLPLVIPRH-IDSLRYVSTIAVSFMVYLVIVI 223
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  169 VLSSFKHGLfsGQWLQRVSY--------IRWEGVFRCVP---IFGMSFACQSQVLPTYDSLDEPSVKTMSSIFASSLNVV 237
Cdd:PTZ00206   224 VVHSCMNGL--PENIKNVSVgkddnaeiILFNSGNRAIEglgVFIFAYVFQITAYEVYMDMTNRSVGKFVLASTIAMGMC 301
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  238 TAFYVMQkdgtfAAGGYM--------------PPLRF------------------------------------------- 260
Cdd:PTZ00206   302 FTMYVLT-----AFFGYMdfgrnvtgsvllmyDPVNEpaimvgfvgvlvklfvsyallgmacrnalydvigwdarkvafw 376
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1958659220  261 ----KVLTLSVVFgtMVGGVMIPNVETILGFTGATMGSLICFICPALIY 305
Cdd:PTZ00206   377 khciAVVTLSVVM--LLCGLFIPKINTVLGFAGSISGGLLGFILPALLF 423
PTZ00121 PTZ00121
MAEBL; Provisional
335-1024 5.05e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.46  E-value: 5.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  335 SVSEEAPLDLTQGARSGQRGDAEGAMKVEAARLSVQDPVVVMA---EDSQ--EKLKPAEDKEVLEQA----QIKGPVDVP 405
Cdd:PTZ00121  1115 RKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIArkaEDARkaEEARKAEDAKKAEAArkaeEVRKAEELR 1194
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  406 GGDTPKEKQEAAQLDRPGQGIAVPMGE-AHRHEPPIPHDKVVVDEGQDQEGPEEKKPPPKLPDEGDPA---GRGQGAPLL 481
Cdd:PTZ00121  1195 KAEDARKAEAARKAEEERKAEEARKAEdAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMahfARRQAAIKA 1274
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  482 PESEKKQDPERGEEGKRPEQVLAVGEI----ERPQKIPEANGQPPVQPRKEDSRPGNRDLHPVPQ-----ARVSVELNDL 552
Cdd:PTZ00121  1275 EEARKADELKKAEEKKKADEAKKAEEKkkadEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEeakkaAEAAKAEAEA 1354
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  553 VAGEGKESAQKAGGAPWKPMESAVESNIGGKAGLAVQRPE-----------AAEQREKNEAEQPGGDQAGSKLEA----- 616
Cdd:PTZ00121  1355 AADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADeakkkaeedkkKADELKKAAAAKKKADEAKKKAEEkkkad 1434
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  617 EIKKLVAEAGRAEMLDHAVLLQVIKE---QQVQQKRLLDQQEKLlaviEEQHKEIRQQRQEGEEDKPKPADM----QPEP 689
Cdd:PTZ00121  1435 EAKKKAEEAKKADEAKKKAEEAKKAEeakKKAEEAKKADEAKKK----AEEAKKADEAKKKAEEAKKKADEAkkaaEAKK 1510
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  690 GAAVLRGQEE--EAEHAGAPDE--HAGETLEDNPSQPLQPVLGAPRGHPAPSQDKGQHP--LEEVKVLAGRDLADL---- 759
Cdd:PTZ00121  1511 KADEAKKAEEakKADEAKKAEEakKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAkkAEEDKNMALRKAEEAkkae 1590
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  760 ------PAGGSDTEPHGASSKLREDQ----KGAALKVAEAVRKLVpgdlEPVHKPDPAEVPKSPEKQLAKEVARQRQDVF 829
Cdd:PTZ00121  1591 earieeVMKLYEEEKKMKAEEAKKAEeakiKAEELKKAEEEKKKV----EQLKKKEAEEKKKAEELKKAEEENKIKAAEE 1666
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  830 GEGSQERKETGKDAVAPGADTQKEAAQPLVGAEAEDSHSKSRHSEPTKVpasgpagmgfQAQARFRQEPQVIFDKSQDSH 909
Cdd:PTZ00121  1667 AKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEK----------KKAEELKKAEEENKIKAEEAK 1736
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  910 PEVRSEGPRGVGIPAEEQHRGRGAAAMQEEKQRPDPNSGPKLAVPG---DQKPENAKPNRDLKVqagsdlrrrrrdlasp 986
Cdd:PTZ00121  1737 KEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEeelDEEDEKRRMEVDKKI---------------- 1800
                          730       740       750
                   ....*....|....*....|....*....|....*...
gi 1958659220  987 peQELAPKDGVIISFNSLPNVQVNDLRSALDTQLRQAA 1024
Cdd:PTZ00121  1801 --KDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVA 1836
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
638-793 4.62e-04

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 43.84  E-value: 4.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  638 QVIKEQ-QVQQKRLLDQQEKL---LAVIEEQHKEIRQQRQEgEEDKPKPADMQ-PEPGAAVLRGQEEEAEHAGAPDEHAG 712
Cdd:pfam05262  216 QQLKEElDKKQIDADKAQQKAdfaQDNADKQRDEVRQKQQE-AKNLPKPADTSsPKEDKQVAENQKREIEKAQIEIKKND 294
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  713 ETLEDNPSQPLQPVLGAPRGHPAPSQDKGQHPLEEVKVLAGrDLADLPAGGSDTEPHGASSKLREDQKGAALKVAEAVRK 792
Cdd:pfam05262  295 EEALKAKDHKAFDLKQESKASEKEAEDKELEAQKKREPVAE-DLQKTKPQVEAQPTSLNEDAIDSSNPVYGLKVVDPITN 373

                   .
gi 1958659220  793 L 793
Cdd:pfam05262  374 L 374
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
593-702 1.29e-03

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 42.55  E-value: 1.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  593 AAEQREKNEAeqpggdQAGSKLEAEIKKLVAEAgraemldhAVLLQ-VIKEQQVQQKRLLDQQEKllaVIEEQHKEIRQQ 671
Cdd:COG2268    240 AEAEAELAKK------KAEERREAETARAEAEA--------AYEIAeANAEREVQRQLEIAERER---EIELQEKEAERE 302
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958659220  672 RQEGEEDKPKPADMQPEpgAAVlrgQEEEAE 702
Cdd:COG2268    303 EAELEADVRKPAEAEKQ--AAE---AEAEAE 328
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
6-320 1.29e-30

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 125.88  E-value: 1.29e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220    6 TSKWGLVTNVVNSIVGVSVLTMPFCFKQCGIVLGALLLVFCSWMTHQSCMFLVKSA-----SLSKRRTYAGLAFHAYGKA 80
Cdd:pfam01490    3 ISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCSkevpvTGKRNKSYGDLGYRLLGPK 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220   81 GKMLVETSMIGLMLGSCITFYVVIGDLGSNFFAPLLGlqvTRTFRVFLLFAVSLCIVLPLSLQRNMMA-SIqsFSAMALL 159
Cdd:pfam01490   83 GRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFD---TCPISLVYFIIIFGLIFIPLSFIPNLSAlSI--LSLLAAV 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  160 FYTVFMFVIVLSSFKHGLFSGQ---WLQRVSYIRWEGVFRCVPIFGMSFACQSQVLPTYDSLDEPSV-KTMSSIFASSLN 235
Cdd:pfam01490  158 SSLYYIVILVLSVAEGIVLTAQgvgHLGSKTNIKLAGTFLAIGIIVFAFEGHAVLLPIQNEMKNPSKfKAMTKILLTAII 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  236 VVTAFYV----------------------------------------------------------MQKDGTFAAGGYMPP 257
Cdd:pfam01490  238 IATVLYIliglvgylafgdnvkgnillnlpksawlidianlllvlhvilsfplqlfpirqivenlLFRKEAPFGASGKNN 317
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958659220  258 ----LRFKVLTLSVVFGTMVGGVMIPNVETILGFTGATMGSLICFICPALIYKKAHKNAPSAQVVLW 320
Cdd:pfam01490  318 pkskLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLKLKKTKKKSQEKLW 384
PTZ00206 PTZ00206
amino acid transporter; Provisional
14-305 7.34e-11

amino acid transporter; Provisional


Pssm-ID: 240313  Cd Length: 467  Bit Score: 65.66  E-value: 7.34e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220   14 NVVNSIVGVSVLTMPFCFKQCGIVLGALLLVFCSWMTHQSCMFLVKSASLSKRRTYAGLAFHAYGKAGKMLVETSMIGLM 93
Cdd:PTZ00206    68 NIASSTVGAGIVGLPSAANSSGLVMAMIYLIIITAMTIFSIYALGVAADKTNIRTYEGVARVLLGPWGSYYVAATRAFHG 147
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220   94 LGSCITFYVVIGDLGSnffAPLLGLQV-----TRTFRVFLLFAVSLCIVLPLSLQRNmMASIQSFSAMALLFYTVFMFVI 168
Cdd:PTZ00206   148 FSACVAYVISVGDILS---ATLKGTNApdflkQKSGNRLLTSLMWLCFMLPLVIPRH-IDSLRYVSTIAVSFMVYLVIVI 223
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  169 VLSSFKHGLfsGQWLQRVSY--------IRWEGVFRCVP---IFGMSFACQSQVLPTYDSLDEPSVKTMSSIFASSLNVV 237
Cdd:PTZ00206   224 VVHSCMNGL--PENIKNVSVgkddnaeiILFNSGNRAIEglgVFIFAYVFQITAYEVYMDMTNRSVGKFVLASTIAMGMC 301
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  238 TAFYVMQkdgtfAAGGYM--------------PPLRF------------------------------------------- 260
Cdd:PTZ00206   302 FTMYVLT-----AFFGYMdfgrnvtgsvllmyDPVNEpaimvgfvgvlvklfvsyallgmacrnalydvigwdarkvafw 376
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1958659220  261 ----KVLTLSVVFgtMVGGVMIPNVETILGFTGATMGSLICFICPALIY 305
Cdd:PTZ00206   377 khciAVVTLSVVM--LLCGLFIPKINTVLGFAGSISGGLLGFILPALLF 423
PTZ00121 PTZ00121
MAEBL; Provisional
335-1024 5.05e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.46  E-value: 5.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  335 SVSEEAPLDLTQGARSGQRGDAEGAMKVEAARLSVQDPVVVMA---EDSQ--EKLKPAEDKEVLEQA----QIKGPVDVP 405
Cdd:PTZ00121  1115 RKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIArkaEDARkaEEARKAEDAKKAEAArkaeEVRKAEELR 1194
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  406 GGDTPKEKQEAAQLDRPGQGIAVPMGE-AHRHEPPIPHDKVVVDEGQDQEGPEEKKPPPKLPDEGDPA---GRGQGAPLL 481
Cdd:PTZ00121  1195 KAEDARKAEAARKAEEERKAEEARKAEdAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMahfARRQAAIKA 1274
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  482 PESEKKQDPERGEEGKRPEQVLAVGEI----ERPQKIPEANGQPPVQPRKEDSRPGNRDLHPVPQ-----ARVSVELNDL 552
Cdd:PTZ00121  1275 EEARKADELKKAEEKKKADEAKKAEEKkkadEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEeakkaAEAAKAEAEA 1354
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  553 VAGEGKESAQKAGGAPWKPMESAVESNIGGKAGLAVQRPE-----------AAEQREKNEAEQPGGDQAGSKLEA----- 616
Cdd:PTZ00121  1355 AADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADeakkkaeedkkKADELKKAAAAKKKADEAKKKAEEkkkad 1434
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  617 EIKKLVAEAGRAEMLDHAVLLQVIKE---QQVQQKRLLDQQEKLlaviEEQHKEIRQQRQEGEEDKPKPADM----QPEP 689
Cdd:PTZ00121  1435 EAKKKAEEAKKADEAKKKAEEAKKAEeakKKAEEAKKADEAKKK----AEEAKKADEAKKKAEEAKKKADEAkkaaEAKK 1510
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  690 GAAVLRGQEE--EAEHAGAPDE--HAGETLEDNPSQPLQPVLGAPRGHPAPSQDKGQHP--LEEVKVLAGRDLADL---- 759
Cdd:PTZ00121  1511 KADEAKKAEEakKADEAKKAEEakKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAkkAEEDKNMALRKAEEAkkae 1590
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  760 ------PAGGSDTEPHGASSKLREDQ----KGAALKVAEAVRKLVpgdlEPVHKPDPAEVPKSPEKQLAKEVARQRQDVF 829
Cdd:PTZ00121  1591 earieeVMKLYEEEKKMKAEEAKKAEeakiKAEELKKAEEEKKKV----EQLKKKEAEEKKKAEELKKAEEENKIKAAEE 1666
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  830 GEGSQERKETGKDAVAPGADTQKEAAQPLVGAEAEDSHSKSRHSEPTKVpasgpagmgfQAQARFRQEPQVIFDKSQDSH 909
Cdd:PTZ00121  1667 AKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEK----------KKAEELKKAEEENKIKAEEAK 1736
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  910 PEVRSEGPRGVGIPAEEQHRGRGAAAMQEEKQRPDPNSGPKLAVPG---DQKPENAKPNRDLKVqagsdlrrrrrdlasp 986
Cdd:PTZ00121  1737 KEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEeelDEEDEKRRMEVDKKI---------------- 1800
                          730       740       750
                   ....*....|....*....|....*....|....*...
gi 1958659220  987 peQELAPKDGVIISFNSLPNVQVNDLRSALDTQLRQAA 1024
Cdd:PTZ00121  1801 --KDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVA 1836
PTZ00121 PTZ00121
MAEBL; Provisional
344-941 2.56e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.07  E-value: 2.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  344 LTQGARSGQRGDAEGAMKVEAARLSvqdpvvvmAEDSQ--EKLKPAEDKEVLEQAqiKGPVDVPGGDTPKEKQEAAQLDr 421
Cdd:PTZ00121  1099 KAEEAKKTETGKAEEARKAEEAKKK--------AEDARkaEEARKAEDARKAEEA--RKAEDAKRVEIARKAEDARKAE- 1167
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  422 pgqgIAVPMGEAHRHEPPIPHDKVvvdegqdQEGPEEKKpppklpdeGDPAGRGQGAPLLPESEKKQDPERGEEGKRPEQ 501
Cdd:PTZ00121  1168 ----EARKAEDAKKAEAARKAEEV-------RKAEELRK--------AEDARKAEAARKAEEERKAEEARKAEDAKKAEA 1228
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  502 VLAVGEIERpqKIPEANgqppvQPRKEDSRPGNRDLHPVPQARVSVELNDLVAGEGKESAQKAGGAPWKPMESAVESNIG 581
Cdd:PTZ00121  1229 VKKAEEAKK--DAEEAK-----KAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEK 1301
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  582 GKAGLAVQRPEAAEQRE--KNEAEQPGGDQAGSKLEAEIKKLVAEAGRAEMLDHAVLLQVIKEQQVQQKRLLDQQEKLLA 659
Cdd:PTZ00121  1302 KKADEAKKKAEEAKKADeaKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKAD 1381
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  660 VIEEQHKEIR---QQRQEGEEDKpKPADMQPEPGAAVLRGQE--EEAEHAGAPDEHAGETLEDNPSQPL-QPVLGAPRGH 733
Cdd:PTZ00121  1382 AAKKKAEEKKkadEAKKKAEEDK-KKADELKKAAAAKKKADEakKKAEEKKKADEAKKKAEEAKKADEAkKKAEEAKKAE 1460
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  734 PAPSQDKGQHPLEEVKVLA--GRDLADLPAGGSDTEPHGASSKLREDQKGAA--LKVAEAVRKlvpgdLEPVHKPDPA-- 807
Cdd:PTZ00121  1461 EAKKKAEEAKKADEAKKKAeeAKKADEAKKKAEEAKKKADEAKKAAEAKKKAdeAKKAEEAKK-----ADEAKKAEEAkk 1535
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  808 --EVPKSPEKQLAKEVaRQRQDVfgegsqeRKETGKDAVAPGADTQKEAAQPLVGAEAEDSHSKSRHSEPTKVPASGPAG 885
Cdd:PTZ00121  1536 adEAKKAEEKKKADEL-KKAEEL-------KKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKM 1607
                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958659220  886 MGFQAQarfRQEPQVIFDKSQDSHPEVRSEGPRGVGIPAEEQHRGRGAAAMQEEKQ 941
Cdd:PTZ00121  1608 KAEEAK---KAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENK 1660
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
638-793 4.62e-04

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 43.84  E-value: 4.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  638 QVIKEQ-QVQQKRLLDQQEKL---LAVIEEQHKEIRQQRQEgEEDKPKPADMQ-PEPGAAVLRGQEEEAEHAGAPDEHAG 712
Cdd:pfam05262  216 QQLKEElDKKQIDADKAQQKAdfaQDNADKQRDEVRQKQQE-AKNLPKPADTSsPKEDKQVAENQKREIEKAQIEIKKND 294
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  713 ETLEDNPSQPLQPVLGAPRGHPAPSQDKGQHPLEEVKVLAGrDLADLPAGGSDTEPHGASSKLREDQKGAALKVAEAVRK 792
Cdd:pfam05262  295 EEALKAKDHKAFDLKQESKASEKEAEDKELEAQKKREPVAE-DLQKTKPQVEAQPTSLNEDAIDSSNPVYGLKVVDPITN 373

                   .
gi 1958659220  793 L 793
Cdd:pfam05262  374 L 374
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
593-702 1.29e-03

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 42.55  E-value: 1.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  593 AAEQREKNEAeqpggdQAGSKLEAEIKKLVAEAgraemldhAVLLQ-VIKEQQVQQKRLLDQQEKllaVIEEQHKEIRQQ 671
Cdd:COG2268    240 AEAEAELAKK------KAEERREAETARAEAEA--------AYEIAeANAEREVQRQLEIAERER---EIELQEKEAERE 302
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958659220  672 RQEGEEDKPKPADMQPEpgAAVlrgQEEEAE 702
Cdd:COG2268    303 EAELEADVRKPAEAEKQ--AAE---AEAEAE 328
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
97-243 3.87e-03

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 40.33  E-value: 3.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220   97 CITFYVVIG---DLGSNFFAPLLGLQVTRTFRVFLLFavSLCIVLPlSLQRNMMASIQSFSAMALLFYTVFMFVIVLSSF 173
Cdd:pfam00520   70 ILDFVVVLPsliSLVLSSVGSLSGLRVLRLLRLLRLL--RLIRRLE-GLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAII 146
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958659220  174 KHGLFSGQWLQRVSYIRWEGVFRcvpIFGMSFACQSQVLPT-------YDSLDEPSVKTMSSIFAsSLNVVTAFYVM 243
Cdd:pfam00520  147 GYQLFGGKLKTWENPDNGRTNFD---NFPNAFLWLFQTMTTegwgdimYDTIDGKGEFWAYIYFV-SFIILGGFLLL 219
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
516-936 5.08e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 5.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  516 EANGQPPVQPRKEDSRPGNRDLHPVPQARVSVELNDLVAGEGKESAQKAGGAPWK---PMESAVESNIGGKAGLAVQRPE 592
Cdd:PRK07764   410 PAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAqpaPAPAAAPEPTAAPAPAPPAAPA 489
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  593 -AAEQREKNEAEQPGGDQAGSKLE---AEIKKLVAEAGR---AEMLDHAVLLQVIKEQQV-------QQKRLLDQQ--EK 656
Cdd:PRK07764   490 pAAAPAAPAAPAAPAGADDAATLRerwPEILAAVPKRSRktwAILLPEATVLGVRGDTLVlgfstggLARRFASPGnaEV 569
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  657 LLAVIEEQHkeirqqrqeGEEDKPkpadmqpepgaavlrgqeeEAEHAGAPDEHAGETLEDNPSQPLQPVLGAPRGHPAP 736
Cdd:PRK07764   570 LVTALAEEL---------GGDWQV-------------------EAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAP 621
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  737 SQDKGQHPleevkvlagrdladlpaGGSDTEPHGASSKLREDQKGAALKVAEAVRKLVPGDLEPVHKPDPAEVPKSPEKQ 816
Cdd:PRK07764   622 AAPAAPAP-----------------AGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPA 684
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659220  817 LAKEVARQRQdvfgEGSQERKETGKDAVAPGADTQKEAAQPLVGAEAEDSHSKSRHSEPTKVPASGPAGMGFQAQARFRQ 896
Cdd:PRK07764   685 PAPAAPAAPA----GAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPP 760
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*.
gi 1958659220  897 EPQVIFDKSQDSHPEVRSEGPRGV------GIPAEEQHRGRGAAAM 936
Cdd:PRK07764   761 PPAPAPAAAPAAAPPPSPPSEEEEmaeddaPSMDDEDRRDAEEVAM 806
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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