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Conserved domains on  [gi|1958659093|ref|XP_038942101|]
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WD repeat domain phosphoinositide-interacting protein 1 isoform X2 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
51-242 3.07e-11

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 3.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659093  51 GEIVLYDGNSLKMVCTIAAHEGTLAAITFNSSGSKLASASEKGTViRVFSVPEGQKLYEFRRGMKRyvtISSLVFSMDSQ 130
Cdd:COG2319   142 GTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV-RLWDLATGKLLRTLTGHTGA---VRSVAFSPDGK 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659093 131 FLCASSNTETVHIFKLEqltdsRPEEPSTWSGYMGKMLTAAtnylpaqvsdmmnqdrafatgrlnFS--GQknictlsti 208
Cdd:COG2319   218 LLASGSADGTVRLWDLA-----TGKLLRTLTGHSGSVRSVA------------------------FSpdGR--------- 259

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958659093 209 qklpRLLVASSDGHLYIYNLdpqDGGECVLIKTH 242
Cdd:COG2319   260 ----LLASGSADGTVRLWDL---ATGELLRTLTG 286
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
51-242 3.07e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 3.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659093  51 GEIVLYDGNSLKMVCTIAAHEGTLAAITFNSSGSKLASASEKGTViRVFSVPEGQKLYEFRRGMKRyvtISSLVFSMDSQ 130
Cdd:COG2319   142 GTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV-RLWDLATGKLLRTLTGHTGA---VRSVAFSPDGK 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659093 131 FLCASSNTETVHIFKLEqltdsRPEEPSTWSGYMGKMLTAAtnylpaqvsdmmnqdrafatgrlnFS--GQknictlsti 208
Cdd:COG2319   218 LLASGSADGTVRLWDLA-----TGKLLRTLTGHSGSVRSVA------------------------FSpdGR--------- 259

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958659093 209 qklpRLLVASSDGHLYIYNLdpqDGGECVLIKTH 242
Cdd:COG2319   260 ----LLASGSADGTVRLWDL---ATGELLRTLTG 286
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-147 6.93e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 6.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659093  31 CALSINHSNSYLAypGSQSTGEIVLYDGNSLKMVCTIAAHEGTLAAITFNSSGSKLASASEKGTvIRVFSVPEGQKLYEF 110
Cdd:cd00200   139 NSVAFSPDGTFVA--SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTL 215

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1958659093 111 rRGMKRYVTisSLVFSMDSQFLCASSNTETVHIFKLE 147
Cdd:cd00200   216 -RGHENGVN--SVAFSPDGYLLASGSEDGTIRVWDLR 249
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 60-100 6.82e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 6.82e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1958659093   60 SLKMVCTIAAHEGTLAAITFNSSGSKLASASEKGTvIRVFS 100
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGT-IKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
51-242 3.07e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 3.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659093  51 GEIVLYDGNSLKMVCTIAAHEGTLAAITFNSSGSKLASASEKGTViRVFSVPEGQKLYEFRRGMKRyvtISSLVFSMDSQ 130
Cdd:COG2319   142 GTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV-RLWDLATGKLLRTLTGHTGA---VRSVAFSPDGK 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659093 131 FLCASSNTETVHIFKLEqltdsRPEEPSTWSGYMGKMLTAAtnylpaqvsdmmnqdrafatgrlnFS--GQknictlsti 208
Cdd:COG2319   218 LLASGSADGTVRLWDLA-----TGKLLRTLTGHSGSVRSVA------------------------FSpdGR--------- 259

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958659093 209 qklpRLLVASSDGHLYIYNLdpqDGGECVLIKTH 242
Cdd:COG2319   260 ----LLASGSADGTVRLWDL---ATGELLRTLTG 286
WD40 COG2319
WD40 repeat [General function prediction only];
32-243 5.80e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.01  E-value: 5.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659093  32 ALSINHSNSYLAYpGSQStGEIVLYDGNSLKMVCTIAAHEGTLAAITFNSSGSKLASASEKGTViRVFSVPEGQKLYEFR 111
Cdd:COG2319   209 SVAFSPDGKLLAS-GSAD-GTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV-RLWDLATGELLRTLT 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659093 112 RGMKRyvtISSLVFSMDSQFLCASSNTETVHIFKLEQltdsrPEEPSTWSGYMGKMLTAAtnylpaqvsdmmnqdrafat 191
Cdd:COG2319   286 GHSGG---VNSVAFSPDGKLLASGSDDGTVRLWDLAT-----GKLLRTLTGHTGAVRSVA-------------------- 337

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958659093 192 grlnFS--GQknictlstiqklpRLLVASSDGHLYIYNLDpqDGGECVLIKTHS 243
Cdd:COG2319   338 ----FSpdGK-------------TLASGSDDGTVRLWDLA--TGELLRTLTGHT 372
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-147 6.93e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 6.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659093  31 CALSINHSNSYLAypGSQSTGEIVLYDGNSLKMVCTIAAHEGTLAAITFNSSGSKLASASEKGTvIRVFSVPEGQKLYEF 110
Cdd:cd00200   139 NSVAFSPDGTFVA--SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTL 215

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1958659093 111 rRGMKRYVTisSLVFSMDSQFLCASSNTETVHIFKLE 147
Cdd:cd00200   216 -RGHENGVN--SVAFSPDGYLLASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
51-147 1.07e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.15  E-value: 1.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659093  51 GEIVLYDGNSLKMVCTIAAHEGTLAAITFNSSGSKLASASEKGTViRVFSVPEGQKLYEFrRGMKRYVTisSLVFSMDSQ 130
Cdd:COG2319   310 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV-RLWDLATGELLRTL-TGHTGAVT--SVAFSPDGR 385

                          90
                  ....*....|....*..
gi 1958659093 131 FLCASSNTETVHIFKLE 147
Cdd:COG2319   386 TLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-237 5.84e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 5.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659093  53 IVLYDGNSLKMVCTIAAHEGTLAAITFNSSGSKLASASEKGTvIRVFSVPEGQKLYEFrRGMKRYVTisSLVFSMDSQFL 132
Cdd:cd00200    75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT-IKVWDVETGKCLTTL-RGHTDWVN--SVAFSPDGTFV 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659093 133 CASSNTETVHIFKLEqltdsrpeepstwsgymgkmltaatnylpaqvsdmmnqdrafaTGRL--NFSG-QKNICTLSTIQ 209
Cdd:cd00200   151 ASSSQDGTIKLWDLR-------------------------------------------TGKCvaTLTGhTGEVNSVAFSP 187

                         170       180
                  ....*....|....*....|....*...
gi 1958659093 210 KLPRLLVASSDGHLYIYNLdpqDGGECV 237
Cdd:cd00200   188 DGEKLLSSSSDGTIKLWDL---STGKCL 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-146 1.13e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.26  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659093  31 CALSINHSNSYLAypGSQSTGEIVLYDGNSLKMVCTIAAHEGTLAAITFNSSGSKLASASEKGTvIRVFSVPEGQKLYEF 110
Cdd:cd00200    97 SSVAFSPDGRILS--SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT-IKLWDLRTGKCVATL 173

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958659093 111 rRGMKRYVTisSLVFSMDSQFLCASSNTETVHIFKL 146
Cdd:cd00200   174 -TGHTGEVN--SVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 49-145 4.47e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 4.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659093  49 STGEIVLYDGNSLKMVCTIAAHEGTLAAITFNSSGSKLASASEKGTvIRVFSVPEGQKLYEFRRGMKRyvtISSLVFSMD 128
Cdd:cd00200   197 SDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGT-IRVWDLRTGECVQTLSGHTNS---VTSLAWSPD 272

                          90
                  ....*....|....*..
gi 1958659093 129 SQFLCASSNTETVHIFK 145
Cdd:cd00200   273 GKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 63-162 1.66e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 1.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659093  63 MVCTIAAHEGTLAAITFNSSGSKLASASEKGTvIRVFSVPEGQKLyefRRGMKRYVTISSLVFSMDSQFLCASSNTETVH 142
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGT-IKVWDLETGELL---RTLKGHTGPVRDVAASADGTYLASGSSDKTIR 76

                          90       100
                  ....*....|....*....|
gi 1958659093 143 IFKLEQltdsrPEEPSTWSG 162
Cdd:cd00200    77 LWDLET-----GECVRTLTG 91
WD40 COG2319
WD40 repeat [General function prediction only];
31-102 4.64e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 4.64e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958659093  31 CALSINHSNSYLAYPGSQSTgeIVLYDGNSLKMVCTIAAHEGTLAAITFNSSGSKLASASEKGTvIRVFSVP 102
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGT--VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT-VRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
66-171 3.31e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.12  E-value: 3.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659093  66 TIAAHEGTLAAITFNSSGSKLASASEKGTViRVFSVPEGQKLYEFrRGMKRYVTisSLVFSMDSQFLCASSNTETVHIFK 145
Cdd:COG2319    73 TLLGHTAAVLSVAFSPDGRLLASASADGTV-RLWDLATGLLLRTL-TGHTGAVR--SVAFSPDGKTLASGSADGTVRLWD 148

                          90       100
                  ....*....|....*....|....*.
gi 1958659093 146 LEQltdsrPEEPSTWSGYMGKMLTAA 171
Cdd:COG2319   149 LAT-----GKLLRTLTGHSGAVTSVA 169
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 60-100 6.82e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 6.82e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1958659093   60 SLKMVCTIAAHEGTLAAITFNSSGSKLASASEKGTvIRVFS 100
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGT-IKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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