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Conserved domains on  [gi|1958659082|ref|XP_038942097|]
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PAT complex subunit CCDC47 isoform X1 [Rattus norvegicus]

Protein Classification

CCDC47 family protein( domain architecture ID 12085178)

CCDC47 family protein such as PAT complex subunit CCDC47 (Coiled-coil domain-containing protein 47), a component of the PAT complex that is part of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes

Gene Ontology:  GO:0016020|GO:0005509
PubMed:  32814900

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CCDC47 pfam07946
PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of ...
 18-288 9.18e-87

PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex, formed by CCDC47 and Asterix proteins, acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. CCDC47 is required to maintain the stability of Asterix. CCDC47 is associated with various membrane-associated processes and is component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. It is also involved in the regulation of calcium ion homeostasis in the ER, being also required for proper protein degradation via the ERAD (ER-associated degradation) pathway.


:

Pssm-ID: 462322  Cd Length: 323  Bit Score: 262.50  E-value: 9.18e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659082  18 LNQENEHIYNLWCSGRVCCEGMLIQLRFLKRQDLLNVLARMMR--------PVSDQVQIKVTMNDEDMDTYVFAVGTRKA 89
Cdd:pfam07946  59 LIEDSPSEFTTYATGRRNCAGLLVTLKLKKRQDLFSLLFELVLgfffdsvpPPKDRVEIDVYLFDGKMDPFVFAIVNKKE 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659082  90 LLRLQKEMQDLSeFCSDKPKsgakYGLPDSLAILSEMGEVTEGMMDTKMVHFLTHYADKIESVHFSDQFSGPkimqeegq 169
Cdd:pfam07946 139 MKKLRKDRYDLS-LTKTKDN----PKLPEWLVVMSESAEITDALLTPELIKALNKAGDLLEYLIITDQPSEK-------- 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659082 170 PLKLPDT--KRTLLFTFNVPGSGNtypkDMEALLPLMNMVIYSIDK-AKKFRLNREGKQKADKNRARVEENFLKLTHVQR 246
Cdd:pfam07946 206 PETLKETtpRKRLILSLRLPSSKS----DYEALLPLLQLVLYLIDKlAKRAKLRPEALKKAKKTREEEIEKIKKAAEEER 281

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1958659082 247 QEAAQSRREEKKRAEKERIMNEEDPEKQRRLEEAALRREQKK 288
Cdd:pfam07946 282 AEEAQEKKEEAKKKEREEKLAKLSPEEQRKYEEKERKKEQRK 323
 
Name Accession Description Interval E-value
CCDC47 pfam07946
PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of ...
 18-288 9.18e-87

PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex, formed by CCDC47 and Asterix proteins, acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. CCDC47 is required to maintain the stability of Asterix. CCDC47 is associated with various membrane-associated processes and is component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. It is also involved in the regulation of calcium ion homeostasis in the ER, being also required for proper protein degradation via the ERAD (ER-associated degradation) pathway.


Pssm-ID: 462322  Cd Length: 323  Bit Score: 262.50  E-value: 9.18e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659082  18 LNQENEHIYNLWCSGRVCCEGMLIQLRFLKRQDLLNVLARMMR--------PVSDQVQIKVTMNDEDMDTYVFAVGTRKA 89
Cdd:pfam07946  59 LIEDSPSEFTTYATGRRNCAGLLVTLKLKKRQDLFSLLFELVLgfffdsvpPPKDRVEIDVYLFDGKMDPFVFAIVNKKE 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659082  90 LLRLQKEMQDLSeFCSDKPKsgakYGLPDSLAILSEMGEVTEGMMDTKMVHFLTHYADKIESVHFSDQFSGPkimqeegq 169
Cdd:pfam07946 139 MKKLRKDRYDLS-LTKTKDN----PKLPEWLVVMSESAEITDALLTPELIKALNKAGDLLEYLIITDQPSEK-------- 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659082 170 PLKLPDT--KRTLLFTFNVPGSGNtypkDMEALLPLMNMVIYSIDK-AKKFRLNREGKQKADKNRARVEENFLKLTHVQR 246
Cdd:pfam07946 206 PETLKETtpRKRLILSLRLPSSKS----DYEALLPLLQLVLYLIDKlAKRAKLRPEALKKAKKTREEEIEKIKKAAEEER 281

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1958659082 247 QEAAQSRREEKKRAEKERIMNEEDPEKQRRLEEAALRREQKK 288
Cdd:pfam07946 282 AEEAQEKKEEAKKKEREEKLAKLSPEEQRKYEEKERKKEQRK 323
PTZ00121 PTZ00121
MAEBL; Provisional
 213-288 1.13e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 1.13e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958659082  213 KAKKFRLNREGKQKADKNRARVEENFLKLTHVQRQEAAQSRREE-KKRAEKERIMNE--EDPEKQRRLEEAALRREQKK 288
Cdd:PTZ00121  1379 KADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEaKKKAEEKKKADEakKKAEEAKKADEAKKKAEEAK 1457
 
Name Accession Description Interval E-value
CCDC47 pfam07946
PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of ...
 18-288 9.18e-87

PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex, formed by CCDC47 and Asterix proteins, acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. CCDC47 is required to maintain the stability of Asterix. CCDC47 is associated with various membrane-associated processes and is component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. It is also involved in the regulation of calcium ion homeostasis in the ER, being also required for proper protein degradation via the ERAD (ER-associated degradation) pathway.


Pssm-ID: 462322  Cd Length: 323  Bit Score: 262.50  E-value: 9.18e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659082  18 LNQENEHIYNLWCSGRVCCEGMLIQLRFLKRQDLLNVLARMMR--------PVSDQVQIKVTMNDEDMDTYVFAVGTRKA 89
Cdd:pfam07946  59 LIEDSPSEFTTYATGRRNCAGLLVTLKLKKRQDLFSLLFELVLgfffdsvpPPKDRVEIDVYLFDGKMDPFVFAIVNKKE 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659082  90 LLRLQKEMQDLSeFCSDKPKsgakYGLPDSLAILSEMGEVTEGMMDTKMVHFLTHYADKIESVHFSDQFSGPkimqeegq 169
Cdd:pfam07946 139 MKKLRKDRYDLS-LTKTKDN----PKLPEWLVVMSESAEITDALLTPELIKALNKAGDLLEYLIITDQPSEK-------- 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659082 170 PLKLPDT--KRTLLFTFNVPGSGNtypkDMEALLPLMNMVIYSIDK-AKKFRLNREGKQKADKNRARVEENFLKLTHVQR 246
Cdd:pfam07946 206 PETLKETtpRKRLILSLRLPSSKS----DYEALLPLLQLVLYLIDKlAKRAKLRPEALKKAKKTREEEIEKIKKAAEEER 281

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1958659082 247 QEAAQSRREEKKRAEKERIMNEEDPEKQRRLEEAALRREQKK 288
Cdd:pfam07946 282 AEEAQEKKEEAKKKEREEKLAKLSPEEQRKYEEKERKKEQRK 323
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 212-290 1.11e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 40.32  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958659082 212 DKAKKFRLNREgKQKADKNRARVEENFLKLTHVQR--QEAAQSRREEKKRAEKERIMNEE-DPEKQRRLEEAALRREQKK 288
Cdd:pfam15709 319 DPSKALLEKRE-QEKASRDRLRAERAEMRRLEVERkrREQEEQRRLQQEQLERAEKMREElELEQQRRFEEIRLRKQRLE 397


                  ..
gi 1958659082 289 LE 290
Cdd:pfam15709 398 EE 399
PTZ00121 PTZ00121
MAEBL; Provisional
 213-288 1.13e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 1.13e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958659082  213 KAKKFRLNREGKQKADKNRARVEENFLKLTHVQRQEAAQSRREE-KKRAEKERIMNE--EDPEKQRRLEEAALRREQKK 288
Cdd:PTZ00121  1379 KADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEaKKKAEEKKKADEakKKAEEAKKADEAKKKAEEAK 1457
PTZ00121 PTZ00121
MAEBL; Provisional
 213-290 2.77e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.35  E-value: 2.77e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958659082  213 KAKKFRLNREGKQKADKNRARVEENFLKLTHVQRQEAAQSRREEKKRAEKERIMNE-EDPEKQRRLEEAALRREQKKLE 290
Cdd:PTZ00121  1471 KADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEaKKAEEAKKADEAKKAEEKKKAD 1549
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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