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Conserved domains on  [gi|1958658616|ref|XP_038941941|]
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small G protein signaling modulator 2 isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RUN_SGSM2 cd17704
RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, ...
 1-174 1.07e-119

RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM2.


:

Pssm-ID: 439066  Cd Length: 180  Bit Score: 363.87  E-value: 1.07e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616    1 MEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGDICHKVQELQQQAEGRRPSG 80
Cdd:cd17704      7 MEEAVTRKFVHEDSSHIIALCGVVEACLLHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVEGRKNTQ 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616   81 GSQEALRKQGSSSGKTTALSPQALKHIWVRTALMEKVLDRVVQYLAENCSKYYEKEALLADPVFGPILACLLVGPCALEY 160
Cdd:cd17704     87 STQEELRRQSSTTSKTPPLTPQAIKHIWVRTALIEKVLDKIVQYIVDNCSKYYEKEALMSDPVCGPILASLLVGPCALEY 166

                          170
                   ....*....|....
gi 1958658616  161 TKLKTADHYWTDPS 174
Cdd:cd17704    167 TKLKTADHYWTDPS 180
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 233-401 8.85e-103

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


:

Pssm-ID: 275431  Cd Length: 176  Bit Score: 319.28  E-value: 8.85e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616  233 TRLLYGKNNVLVQPKEDMEAVPGYLSLHQSA-ENLTLKWTPNQLMNGTLGDS-----ELEKSVYWDYALVVPFSQIVCVH 306
Cdd:cd15784      1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGrGNLTLKWTPNQLMNGSSQASsaksnSLDSSVYWDYALSVNLDDIVYIH 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616  307 CHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSIDAEEL 385
Cdd:cd15784     81 CHQQdDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLSEV 160

                          170
                   ....*....|....*.
gi 1958658616  386 GVGRATDYVFRIIYPG 401
Cdd:cd15784    161 KEEQATDYVFRIIYPG 176
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 815-983 4.46e-41

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


:

Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 150.53  E-value: 4.46e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616   815 LHRIDKDVQRCDRNYWYFTTPN---LERLRDIMCSYVWEHLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMKRMSQN 891
Cdd:smart00164   47 VHQIEKDLRRTFPEHSFFQDKEgpgQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKLMERYGPN 126

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616   892 F--PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYfCYRWFLLDFKRELLYEEVFAVWEVIWAARHisseHFVL 969
Cdd:smart00164  127 FylPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPLEIVLRIWDVLFAEGS----DFLF 201

                           170
                    ....*....|....
gi 1958658616   970 FIALALVEAYREII 983
Cdd:smart00164  202 RVALALLKLHRDVL 215
 
Name Accession Description Interval E-value
RUN_SGSM2 cd17704
RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, ...
 1-174 1.07e-119

RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM2.


Pssm-ID: 439066  Cd Length: 180  Bit Score: 363.87  E-value: 1.07e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616    1 MEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGDICHKVQELQQQAEGRRPSG 80
Cdd:cd17704      7 MEEAVTRKFVHEDSSHIIALCGVVEACLLHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVEGRKNTQ 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616   81 GSQEALRKQGSSSGKTTALSPQALKHIWVRTALMEKVLDRVVQYLAENCSKYYEKEALLADPVFGPILACLLVGPCALEY 160
Cdd:cd17704     87 STQEELRRQSSTTSKTPPLTPQAIKHIWVRTALIEKVLDKIVQYIVDNCSKYYEKEALMSDPVCGPILASLLVGPCALEY 166

                          170
                   ....*....|....
gi 1958658616  161 TKLKTADHYWTDPS 174
Cdd:cd17704    167 TKLKTADHYWTDPS 180
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 233-401 8.85e-103

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


Pssm-ID: 275431  Cd Length: 176  Bit Score: 319.28  E-value: 8.85e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616  233 TRLLYGKNNVLVQPKEDMEAVPGYLSLHQSA-ENLTLKWTPNQLMNGTLGDS-----ELEKSVYWDYALVVPFSQIVCVH 306
Cdd:cd15784      1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGrGNLTLKWTPNQLMNGSSQASsaksnSLDSSVYWDYALSVNLDDIVYIH 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616  307 CHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSIDAEEL 385
Cdd:cd15784     81 CHQQdDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLSEV 160

                          170
                   ....*....|....*.
gi 1958658616  386 GVGRATDYVFRIIYPG 401
Cdd:cd15784    161 KEEQATDYVFRIIYPG 176
PH_RBD pfam12068
Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain ...
 234-369 1.64e-51

Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain adopts a Ph-like fold. This domain is found associated with pfam00566.


Pssm-ID: 432305  Cd Length: 149  Bit Score: 177.71  E-value: 1.64e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616  234 RLLYGKNNVLVQPKEDMEAVPGYLSLHQ-SAENLTLKWTPNQLMN-------GTLGDSELE---KSVYWDYALVVPFSQI 302
Cdd:pfam12068    1 RLLYGKNNVFVYPSDIGKPIKGYLSLHQnDKGSVFLKWTPNQLMKsssqpssASSDSEELQspdGKNPWSWAINVNVKEL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958658616  303 VCVHCHQQK--SGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFP 369
Cdd:pfam12068   81 KYIHKHQPNegSPSYIILVTQDGGQFPPLHFPHGGHLLLFLSCLESGLFPVVRLDPPLSRSLSKGKLFP 149
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 815-983 4.46e-41

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 150.53  E-value: 4.46e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616   815 LHRIDKDVQRCDRNYWYFTTPN---LERLRDIMCSYVWEHLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMKRMSQN 891
Cdd:smart00164   47 VHQIEKDLRRTFPEHSFFQDKEgpgQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKLMERYGPN 126

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616   892 F--PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYfCYRWFLLDFKRELLYEEVFAVWEVIWAARHisseHFVL 969
Cdd:smart00164  127 FylPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPLEIVLRIWDVLFAEGS----DFLF 201

                           170
                    ....*....|....
gi 1958658616   970 FIALALVEAYREII 983
Cdd:smart00164  202 RVALALLKLHRDVL 215
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 19-166 2.50e-33

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 125.08  E-value: 2.50e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616   19 ALCGAVEACLLHQLRR------RAAGFLRSDKMAALFTKVGKTCPVAGDICHKVQELQQQaegrrpsggsqealrkqgss 92
Cdd:pfam02759    1 QLCAALEALLSHGLKRssllilRAAGLLPERSFWALLERVGKLVPPAEELLSSVQELEQI-------------------- 60

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958658616   93 sgkTTALSPQALKHIWVRTALMEKVLDRVVQYLAENC---SKYYEKEALLADPVFGPILACLLVGPCALEYTKLKTA 166
Cdd:pfam02759   61 ---HTPYSPDGRGRAWIRLALNEKLLDQWLKLLLSNKellSEYYEPWALLADPEFGEILLGLLVGLSALDFNLCLKL 134
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 816-983 4.02e-29

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 114.66  E-value: 4.02e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616  816 HRIDKDVQRCDRNYWYFTT-PNLERLRDIMCSYVWEHLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMKR------M 888
Cdd:pfam00566   10 EQIEKDVPRTFPHSFFFDNgPGQNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLDEEDAFWCFVSLLENyllrdfY 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616  889 SQNFPNggaMDTHFANMRSLIQILDSELFELMHQNGdYTHFYFCYRWFLLDFKRELLYEEVFAVWEVIWAArhiSSEHFV 968
Cdd:pfam00566   90 TPDFPG---LKRDLYVFEELLKKKLPKLYKHLKELG-LDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLE---GEKFVL 162

                          170
                   ....*....|....*
gi 1958658616  969 LFIALALVEAYREII 983
Cdd:pfam00566  163 FRVALAILKRFREEL 177
COG5210 COG5210
GTPase-activating protein [General function prediction only];
815-1026 2.44e-19

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 92.56  E-value: 2.44e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616  815 LHRIDKDVQRCDRNYWYF---TTPNLERLRDIMCSYVWEHLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMK--RMS 889
Cdd:COG5210    257 ISQIEKDLSRTFPDNSLFqteISIRAENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLESEEQAFWCLVKLLKnyGLP 336

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616  890 QNF-PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFyFCYRWFLLDFKRELLYEEVFAVWEVIWAarHISSEHFV 968
Cdd:COG5210    337 GYFlKNLSGLHRDLKVLDDLVEELDPELYEHLLREGVVLLM-FAFRWFLTLFVREFPLEYALRIWDCLFL--EGSSMLFQ 413

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958658616  969 LFIALALVEAYREIIRDNNMDFTDIIKFFNERAERHDAQEILRIARDLVHKVQMLIDN 1026
Cdd:COG5210    414 LALAILKLLRDKLLKLDSDELLDLLLKQLFLHSGKEAWSSILKFRHGTDRDILLFIED 471
RUN smart00593
domain involved in Ras-like GTPase signaling;
105-161 4.39e-15

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 70.72  E-value: 4.39e-15
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616   105 KHIWVRTALMEKVLDRVVQYLAENC---SKYYEKEALLADPVFGPILACLLVGPCALEYT 161
Cdd:smart00593    1 FRAWIRLALNEKLLSSWLNLLLSDEellSKYYEPWAFLRDPEEGEQLLGLLVGLSALDFN 60
 
Name Accession Description Interval E-value
RUN_SGSM2 cd17704
RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, ...
 1-174 1.07e-119

RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM2.


Pssm-ID: 439066  Cd Length: 180  Bit Score: 363.87  E-value: 1.07e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616    1 MEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGDICHKVQELQQQAEGRRPSG 80
Cdd:cd17704      7 MEEAVTRKFVHEDSSHIIALCGVVEACLLHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVEGRKNTQ 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616   81 GSQEALRKQGSSSGKTTALSPQALKHIWVRTALMEKVLDRVVQYLAENCSKYYEKEALLADPVFGPILACLLVGPCALEY 160
Cdd:cd17704     87 STQEELRRQSSTTSKTPPLTPQAIKHIWVRTALIEKVLDKIVQYIVDNCSKYYEKEALMSDPVCGPILASLLVGPCALEY 166

                          170
                   ....*....|....
gi 1958658616  161 TKLKTADHYWTDPS 174
Cdd:cd17704    167 TKLKTADHYWTDPS 180
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 233-401 8.85e-103

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


Pssm-ID: 275431  Cd Length: 176  Bit Score: 319.28  E-value: 8.85e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616  233 TRLLYGKNNVLVQPKEDMEAVPGYLSLHQSA-ENLTLKWTPNQLMNGTLGDS-----ELEKSVYWDYALVVPFSQIVCVH 306
Cdd:cd15784      1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGrGNLTLKWTPNQLMNGSSQASsaksnSLDSSVYWDYALSVNLDDIVYIH 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616  307 CHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSIDAEEL 385
Cdd:cd15784     81 CHQQdDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLSEV 160

                          170
                   ....*....|....*.
gi 1958658616  386 GVGRATDYVFRIIYPG 401
Cdd:cd15784    161 KEEQATDYVFRIIYPG 176
RUN_SGSM1 cd17703
RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, ...
 1-174 1.08e-92

RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. This model contains the RUN domain of SGSM1.


Pssm-ID: 439065  Cd Length: 177  Bit Score: 292.30  E-value: 1.08e-92
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616    1 MEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGDICHKVQELQQQAEGRRPSG 80
Cdd:cd17703      7 MEEAVTRKFVHEDSSHIISFCAAVEACVLHGLKRRAAGFLRSNKIAALFMKVGKSFPPAEELCRKVQELEQLLENKRNQM 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616   81 -GSQEALRKqgssSGKTTALSPQALKHIWVRTALMEKVLDRVVQYLAENCSKYYEKEALLADPVFGPILACLLVGPCALE 159
Cdd:cd17703     87 qGLQENVRK----MPKLPNLSPQAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALE 162

                          170
                   ....*....|....*
gi 1958658616  160 YTKLKTADHYWTDPS 174
Cdd:cd17703    163 YTKMKTADHFWTDPS 177
RUN_SGSM1_like cd17687
RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; ...
 1-162 2.81e-76

RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM1 and SGSM2.


Pssm-ID: 439049  Cd Length: 161  Bit Score: 247.20  E-value: 2.81e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616    1 MEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGDICHKVQELQQQAEGRRPSG 80
Cdd:cd17687      7 MEEAVTRKFIHEDSSSVTSLCGAVDACLLHGLRKRALGLFRSSSTFSLLQKVAKSCPPAADILRKVQEIENLSENKRSSS 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616   81 GSqealrkqGSSSGKTTALSPQALKHIWVRTALMEKVLDRVVQYLAENCSKYYEKEALLADPVFGPILACLLVGPCALEY 160
Cdd:cd17687     87 SS-------GSNSSNSHGNSSSNRKILWIRIALFEKVLDKIVDYLVENASKYYEKEALMADPVDGPLLASLLVGPCALDY 159


                   ..
gi 1958658616  161 TK 162
Cdd:cd17687    160 TK 161
PH_RBD pfam12068
Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain ...
 234-369 1.64e-51

Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain adopts a Ph-like fold. This domain is found associated with pfam00566.


Pssm-ID: 432305  Cd Length: 149  Bit Score: 177.71  E-value: 1.64e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616  234 RLLYGKNNVLVQPKEDMEAVPGYLSLHQ-SAENLTLKWTPNQLMN-------GTLGDSELE---KSVYWDYALVVPFSQI 302
Cdd:pfam12068    1 RLLYGKNNVFVYPSDIGKPIKGYLSLHQnDKGSVFLKWTPNQLMKsssqpssASSDSEELQspdGKNPWSWAINVNVKEL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958658616  303 VCVHCHQQK--SGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFP 369
Cdd:pfam12068   81 KYIHKHQPNegSPSYIILVTQDGGQFPPLHFPHGGHLLLFLSCLESGLFPVVRLDPPLSRSLSKGKLFP 149
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 815-983 4.46e-41

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 150.53  E-value: 4.46e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616   815 LHRIDKDVQRCDRNYWYFTTPN---LERLRDIMCSYVWEHLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMKRMSQN 891
Cdd:smart00164   47 VHQIEKDLRRTFPEHSFFQDKEgpgQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKLMERYGPN 126

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616   892 F--PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYfCYRWFLLDFKRELLYEEVFAVWEVIWAARHisseHFVL 969
Cdd:smart00164  127 FylPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPLEIVLRIWDVLFAEGS----DFLF 201

                           170
                    ....*....|....
gi 1958658616   970 FIALALVEAYREII 983
Cdd:smart00164  202 RVALALLKLHRDVL 215
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 19-166 2.50e-33

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 125.08  E-value: 2.50e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616   19 ALCGAVEACLLHQLRR------RAAGFLRSDKMAALFTKVGKTCPVAGDICHKVQELQQQaegrrpsggsqealrkqgss 92
Cdd:pfam02759    1 QLCAALEALLSHGLKRssllilRAAGLLPERSFWALLERVGKLVPPAEELLSSVQELEQI-------------------- 60

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958658616   93 sgkTTALSPQALKHIWVRTALMEKVLDRVVQYLAENC---SKYYEKEALLADPVFGPILACLLVGPCALEYTKLKTA 166
Cdd:pfam02759   61 ---HTPYSPDGRGRAWIRLALNEKLLDQWLKLLLSNKellSEYYEPWALLADPEFGEILLGLLVGLSALDFNLCLKL 134
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 816-983 4.02e-29

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 114.66  E-value: 4.02e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616  816 HRIDKDVQRCDRNYWYFTT-PNLERLRDIMCSYVWEHLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMKR------M 888
Cdd:pfam00566   10 EQIEKDVPRTFPHSFFFDNgPGQNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLDEEDAFWCFVSLLENyllrdfY 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616  889 SQNFPNggaMDTHFANMRSLIQILDSELFELMHQNGdYTHFYFCYRWFLLDFKRELLYEEVFAVWEVIWAArhiSSEHFV 968
Cdd:pfam00566   90 TPDFPG---LKRDLYVFEELLKKKLPKLYKHLKELG-LDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLE---GEKFVL 162

                          170
                   ....*....|....*
gi 1958658616  969 LFIALALVEAYREII 983
Cdd:pfam00566  163 FRVALAILKRFREEL 177
COG5210 COG5210
GTPase-activating protein [General function prediction only];
815-1026 2.44e-19

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 92.56  E-value: 2.44e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616  815 LHRIDKDVQRCDRNYWYF---TTPNLERLRDIMCSYVWEHLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMK--RMS 889
Cdd:COG5210    257 ISQIEKDLSRTFPDNSLFqteISIRAENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLESEEQAFWCLVKLLKnyGLP 336

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616  890 QNF-PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFyFCYRWFLLDFKRELLYEEVFAVWEVIWAarHISSEHFV 968
Cdd:COG5210    337 GYFlKNLSGLHRDLKVLDDLVEELDPELYEHLLREGVVLLM-FAFRWFLTLFVREFPLEYALRIWDCLFL--EGSSMLFQ 413

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958658616  969 LFIALALVEAYREIIRDNNMDFTDIIKFFNERAERHDAQEILRIARDLVHKVQMLIDN 1026
Cdd:COG5210    414 LALAILKLLRDKLLKLDSDELLDLLLKQLFLHSGKEAWSSILKFRHGTDRDILLFIED 471
RUN smart00593
domain involved in Ras-like GTPase signaling;
105-161 4.39e-15

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 70.72  E-value: 4.39e-15
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616   105 KHIWVRTALMEKVLDRVVQYLAENC---SKYYEKEALLADPVFGPILACLLVGPCALEYT 161
Cdd:smart00593    1 FRAWIRLALNEKLLSSWLNLLLSDEellSKYYEPWAFLRDPEEGEQLLGLLVGLSALDFN 60
RUN cd17671
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
 10-158 1.18e-12

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


Pssm-ID: 439038  Cd Length: 154  Bit Score: 66.68  E-value: 1.18e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616   10 VHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSdkmaalftkvgktcpvagDICHKVQELQQQAEGRrpsgGSQEALRkq 89
Cdd:cd17671     24 LTDDDPVVGRLCAALEAILSHGLKPKRFGGGKV------------------SFWDFLEALEKLLPAP----SLKQAIR-- 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958658616   90 gSSSGKTTALSPQALKHIWVRTALMEKVLDRVVQYLAEN---CSKYYEKEALLADPVFGPILACLLVGPCAL 158
Cdd:cd17671     80 -DINSLSNVKTDDGRGRAWIRLALNEKSLESYLAALLSDqslLRKYYEPWALLRDPEEAELFLSLLVGLSSL 150
PH-like cd00900
Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like ...
 239-344 1.87e-07

Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but lack significant sequence similarity. They are generally involved in targeting to protein to the appropriate cellular location or interacting with a binding partner. This domain family possesses multiple functions including the ability to bind inositol phosphates and to other proteins.


Pssm-ID: 275390  Cd Length: 89  Bit Score: 49.70  E-value: 1.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616  239 KNNVLVQPKEDMEAVPGYLSLHQSaenlTLKWTPNQLMngtlgdseleksvywDYALVVPFSQIVCVHCHQQ-KSGGTLV 317
Cdd:cd00900      2 KFRAVRVYREPTKRVEGTLYITSD----RLILRDKNDG---------------GLELSIPISDIVNVNVSPQgPSSRYLV 62

                           90       100
                   ....*....|....*....|....*..
gi 1958658616  318 LVSQDGIQRPPLHFPQGGHLLSFLSCL 344
Cdd:cd00900     63 LVLKDRGEFVGFSFPKEEDAIEISDAL 89
RUN_SNX29 cd17689
RUN domain found in sorting nexin-29 (SNX29) and similar proteins; SNX29, also called RUN ...
 12-141 1.77e-04

RUN domain found in sorting nexin-29 (SNX29) and similar proteins; SNX29, also called RUN domain-containing protein 2A (RUNDC2A), belongs to the sorting nexin family. Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain, a phospholipid-binding motif, or through protein-protein interactions with membrane-associated protein complexes. Some sorting nexin family members have been shown to facilitate protein sorting. This model contains the RUN domain of SNX29.


Pssm-ID: 439051  Cd Length: 166  Bit Score: 43.37  E-value: 1.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616   12 EDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGDIC--HKVQELQQQAEGRRpsggsQEALRKQ 89
Cdd:cd17689     22 ESDSRVSCLCAQLEAVLQHGLKTSRSPNLVSSAVTQVSGLAGSLGSAETEPTfwPFVKEHLTKHELER-----FELLKNI 96

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958658616   90 GSSSGKTTAlspqalkhiWVRTALMEKVLDRVVQYLAEN---CSKYYEKEALLAD 141
Cdd:cd17689     97 WTDIGRGRA---------WLRSALNEHSLERYLHILLSNenlLRQYYEDWAFLRD 142
RUN_RUFY1_like cd17681
RUN domain found in RUN and FYVE domain-containing proteins, RUFY1, RUFY2, RUFY3 and similar ...
 12-154 5.91e-04

RUN domain found in RUN and FYVE domain-containing proteins, RUFY1, RUFY2, RUFY3 and similar proteins; This family includes RUN and FYVE domain-containing protein RUFY1, RUFY2, and RUFY3. RUFY1, also called FYVE-finger protein EIP1, or La-binding protein 1, or Rab4-interacting protein (Rabip4), or Zinc finger FYVE domain-containing protein 12 (ZFY12), a human homolog of mouse Rabip4, an effector of Rab4 GTPase that regulates recycling of endocytosed cargo. RUFY1 is an endosomal protein that functions as a dual effector of Rab4 and Rab14 and is involved in efficient recycling of transferrin (Tfn). It is a downstream effector of Etk, a downstream tyrosine kinase of PI3-kinase that is involved in regulation of vesicle trafficking. RUFY2, also called Rab4-interacting protein related, is a novel embryonic factor that is present in the nucleus at early stages of embryonic development. It may have both endosomal functions in the cytoplasm and nuclear functions. RUFY3, also called Rap2-interacting protein x (RIPx or RPIPx), or single axon-regulated protein (singar), is an N-terminal RUN domain and a C-terminal FYVE domain containing protein predominantly expressed in the brain. It suppresses formation of surplus axons for neuronal polarity. Unlike other RUFY proteins, RUFY3 can associate with the GTP-bound active form of Rab5. RUFY1, RUFY2, and RUFY3 contain an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439043  Cd Length: 155  Bit Score: 41.40  E-value: 5.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616   12 EDSSHIIALCGAVEACLLHQLRRRAaGFLRSDK-MAALFTKVGKTCPVAGDICHKVQELqqqaEGRRpsggsqealrkqg 90
Cdd:cd17681     29 SDHVPLQQFFVILEHVLRHGLKVKK-SFLGPNKsFWPVLEHVEKLVPEANEITASVRDL----PGIK------------- 90

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958658616   91 SSSGKTTAlspqalkhiWVRTALMEKVLDRVVQYLAEN---CSKYYEKEALL-ADPvfGPILACLLVG 154
Cdd:cd17681     91 TPLGRARA---------WLRLALMQKKLADYFRALIENkdlLSEFYEPGALMmSEE--AVVIAGLLVG 147
RUN_RUFY4_like cd17682
RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil ...
 12-152 1.76e-03

RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil domain-containing protein 1 (FYCO1), and similar proteins; The family includes RUFY4 and FYCO1. RUFY4 acts as a positive regulator that enhances autophagy and lysosome tethering in response to Interleukin-4. It is expressed in a cell-specific manner or under specific immunological conditions associated with IL4 expression such as allergic asthma. FYCO1, also called zinc finger FYVE domain-containing protein 7 (ZFYVE7), is a multidomain autophagy adaptor protein that interacts with kinesin motor proteins and with the autophagosomal membrane components microtubule-associated protein 1 light chain 3 (LC3), Rab7, and phosphatidylinositol 3-phosphate (PI3P), to mediate microtubule plus-end-directed autophagosome transport. Both RUFY4 and FYCO1 contain an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439044  Cd Length: 150  Bit Score: 39.90  E-value: 1.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658616   12 EDSSHIIALCGAVEACLLHQLRRRAAGFLRS----DKMAALFTKVGKTCPVAGDICHKVQELqqqaegrrpsggsqealR 87
Cdd:cd17682     19 PDNPYLRPFCETLEKILRKGLKEKVSLGGRRkdywDWLEELLKKLNKIPKSLSDAVKFVKSC-----------------K 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958658616   88 KQGSSSGKTTALspqalkhiwVRTALMEKVLDRVVQYLAEN---CSKYYEKEALLADPVFGPILACLL 152
Cdd:cd17682     82 KVKTNQGRGRLF---------IRYALNKKCLHDPVQQLVKNpklLSDYYSPDSILGNEILSEILLSLL 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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