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Conserved domains on  [gi|1958658528|ref|XP_038941915|]
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neuralized-like protein 4 isoform X2 [Rattus norvegicus]

Protein Classification

SPRY_NHR_like domain-containing protein( domain architecture ID 10191474)

SPRY_NHR_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 698-860 1.85e-86

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 278.62  E-value: 1.85e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  698 RFHQLHGSNAVITNGGRTALRhnCRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLEFPNTMTD 777
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  778 IDYDTWMLSGTAIMQDGNTMRNNYGCDLDALGTGARIGMMRTAKGDLHYFINGQDQGAACSGLPPEVYAVVDLYGQCVQV 857
Cdd:cd12887     79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                   ...
gi 1958658528  858 SIT 860
Cdd:cd12887    159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 503-664 8.73e-86

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 276.70  E-value: 8.73e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  503 FHPNCGQKAAITHEGRTALRPHatDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTMTNL 582
Cdd:cd12887      2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  583 RSGTWMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVVRREDGTLHFFVNGMTQGPAAWNVPPGVYAVVDLYGQAAQAT 662
Cdd:cd12887     80 KSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVS 159


                   ..
gi 1958658528  663 IV 664
Cdd:cd12887    160 IV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 45-207 3.55e-78

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 255.13  E-value: 3.55e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528   45 ELHPRTGRLVSLSACGRTARRqqPGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVLDFPSSATG 124
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  125 LKGGSWVVSGCSVLRDGRSVLEEYGQDLDQLVEGDRVGVERTATGELRLWVNGRDCGVAATGLPARVWAVVDLYGKCTQI 204
Cdd:cd12887     79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                   ...
gi 1958658528  205 TVL 207
Cdd:cd12887    159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 300-462 1.45e-77

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 253.20  E-value: 1.45e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  300 FHEKCGTLIKLSNNNKTAERRRplDEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPATMTNL 379
Cdd:cd12887      2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  380 QSGTIMMSGCGILTNGKGTRREYCeFSLDELQEGDHIGLTRKSNSALHFFINGIDQGVATPLTPPVVYGVVDLYGMAVKV 459
Cdd:cd12887     80 KSGTWILSGSSVFKNGNKIRENYG-PDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                   ...
gi 1958658528  460 TIV 462
Cdd:cd12887    159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 1110-1269 1.97e-73

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 241.64  E-value: 1.97e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528 1110 EFLENHGKNILLSNGNRTATRVA-SYNQGIVVISQPLVPHMLVQVRIDFLNRQWTSSLVLGVITCPPERLNFPASACALK 1188
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDLK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528 1189 RAAWLLRGRGVFHNGLKICEKFGPNLDTCPEGTILGLRLDSSGGLHLHINGVDQGVAVPDVPQPCHALVDLYGQCEQVTI 1268
Cdd:cd12887     81 SGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVSI 160


                   .
gi 1958658528 1269 V 1269
Cdd:cd12887    161 V 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 893-1061 8.61e-58

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 196.58  E-value: 8.61e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  893 RFHSTCGKNVTLEEDGTRAVRVA-GYAHGLVFSTKELKAEEVFEVKVEELDEKWAGSLRLGLTTLAPEDMGpgagsgpgL 971
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLD--------L 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  972 PPSLPELRTKTtWMVSSCEVRRDGHLQRMNYGRNLERLGVGSRVGIRRCADDTMHILVDGEDMGPAATGIAKNVWAVLDL 1051
Cdd:cd12887     73 PPSATDLKSGT-WILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDL 151

                          170
                   ....*....|
gi 1958658528 1052 YGPVRSVAIV 1061
Cdd:cd12887    152 YGQCEQVSIV 161
 
Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 698-860 1.85e-86

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 278.62  E-value: 1.85e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  698 RFHQLHGSNAVITNGGRTALRhnCRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLEFPNTMTD 777
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  778 IDYDTWMLSGTAIMQDGNTMRNNYGCDLDALGTGARIGMMRTAKGDLHYFINGQDQGAACSGLPPEVYAVVDLYGQCVQV 857
Cdd:cd12887     79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                   ...
gi 1958658528  858 SIT 860
Cdd:cd12887    159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 503-664 8.73e-86

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 276.70  E-value: 8.73e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  503 FHPNCGQKAAITHEGRTALRPHatDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTMTNL 582
Cdd:cd12887      2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  583 RSGTWMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVVRREDGTLHFFVNGMTQGPAAWNVPPGVYAVVDLYGQAAQAT 662
Cdd:cd12887     80 KSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVS 159


                   ..
gi 1958658528  663 IV 664
Cdd:cd12887    160 IV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 45-207 3.55e-78

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 255.13  E-value: 3.55e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528   45 ELHPRTGRLVSLSACGRTARRqqPGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVLDFPSSATG 124
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  125 LKGGSWVVSGCSVLRDGRSVLEEYGQDLDQLVEGDRVGVERTATGELRLWVNGRDCGVAATGLPARVWAVVDLYGKCTQI 204
Cdd:cd12887     79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                   ...
gi 1958658528  205 TVL 207
Cdd:cd12887    159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 300-462 1.45e-77

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 253.20  E-value: 1.45e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  300 FHEKCGTLIKLSNNNKTAERRRplDEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPATMTNL 379
Cdd:cd12887      2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  380 QSGTIMMSGCGILTNGKGTRREYCeFSLDELQEGDHIGLTRKSNSALHFFINGIDQGVATPLTPPVVYGVVDLYGMAVKV 459
Cdd:cd12887     80 KSGTWILSGSSVFKNGNKIRENYG-PDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                   ...
gi 1958658528  460 TIV 462
Cdd:cd12887    159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 1110-1269 1.97e-73

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 241.64  E-value: 1.97e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528 1110 EFLENHGKNILLSNGNRTATRVA-SYNQGIVVISQPLVPHMLVQVRIDFLNRQWTSSLVLGVITCPPERLNFPASACALK 1188
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDLK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528 1189 RAAWLLRGRGVFHNGLKICEKFGPNLDTCPEGTILGLRLDSSGGLHLHINGVDQGVAVPDVPQPCHALVDLYGQCEQVTI 1268
Cdd:cd12887     81 SGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVSI 160


                   .
gi 1958658528 1269 V 1269
Cdd:cd12887    161 V 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 893-1061 8.61e-58

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 196.58  E-value: 8.61e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  893 RFHSTCGKNVTLEEDGTRAVRVA-GYAHGLVFSTKELKAEEVFEVKVEELDEKWAGSLRLGLTTLAPEDMGpgagsgpgL 971
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLD--------L 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  972 PPSLPELRTKTtWMVSSCEVRRDGHLQRMNYGRNLERLGVGSRVGIRRCADDTMHILVDGEDMGPAATGIAKNVWAVLDL 1051
Cdd:cd12887     73 PPSATDLKSGT-WILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDL 151

                          170
                   ....*....|
gi 1958658528 1052 YGPVRSVAIV 1061
Cdd:cd12887    152 YGQCEQVSIV 161
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 699-861 3.78e-55

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 188.51  E-value: 3.78e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  699 FHQLHGSNAVITNGGRTALRHNcrsEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLE---FPNTM 775
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTN---SFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  776 TDIDYDTWMLSgtaimQDGNTmrnnygcdldaLGTGARIGMMRTAKGDLHYFINGQDQGAACSGLPP--EVYAVVDLYGQ 853
Cdd:pfam07177   78 TDLRPGYWVVA-----LSGSY-----------LQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDsqPLWAVFDLYGQ 141


                   ....*...
gi 1958658528  854 CVQVSITN 861
Cdd:pfam07177  142 TTQVSILG 149
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 300-462 1.70e-54

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 186.97  E-value: 1.70e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  300 FHEKCGTLIKLSNNNKTAERRRpldEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLE---YPATM 376
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTN---SFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  377 TNLQSGTIMMSgcgiltngkgtrreyceFSLDELQEGDHIGLTRKSNSALHFFINGIDQGVATPLTPP--VVYGVVDLYG 454
Cdd:pfam07177   78 TDLRPGYWVVA-----------------LSGSYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDsqPLWAVFDLYG 140


                   ....*...
gi 1958658528  455 MAVKVTIV 462
Cdd:pfam07177  141 QTTQVSIL 148
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 503-665 1.12e-53

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 184.27  E-value: 1.12e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  503 FHPNCGQKAAITHEGRTALRphaTDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQ---LPSTM 579
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARR---TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  580 TNLRSGTWMMtgngvmhngttILDEYghnldRLKAGDTVGVVRREDGTLHFFVNGMTQGPAAWNVPPG--VYAVVDLYGQ 657
Cdd:pfam07177   78 TDLRPGYWVV-----------ALSGS-----YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDLYGQ 141


                   ....*...
gi 1958658528  658 AAQATIVD 665
Cdd:pfam07177  142 TTQVSILG 149
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 47-207 8.47e-51

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 176.19  E-value: 8.47e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528   47 HPRTGRLVSLSACGRTARRqqpGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVL---DFPSSAT 123
Cdd:pfam07177    2 HPVHGKNVRLSNDGRTARR---TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLrpkALPDLAT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  124 GLKGGSWVVSgcsvlRDGRsvleeygqdldQLVEGDRVGVERTATGELRLWVNGRDCGVAATGLP--ARVWAVVDLYGKC 201
Cdd:pfam07177   79 DLRPGYWVVA-----LSGS-----------YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYGQT 142


                   ....*.
gi 1958658528  202 TQITVL 207
Cdd:pfam07177  143 TQVSIL 148
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 1111-1270 7.21e-46

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 161.93  E-value: 7.21e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528 1111 FLENHGKNILLSNGNRTATRVASYNQGIVVISQPLVPHMLVQVRIDFLNRQWTSSLVLGVITCPPERLN---FPASACAL 1187
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLATDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528 1188 KRAAWLlrgrgvfhngLKICEKfgpnldTCPEGTILGLRLDSSGGLHLHINGVDQGVAVPDVP--QPCHALVDLYGQCEQ 1265
Cdd:pfam07177   81 RPGYWV----------VALSGS------YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYGQTTQ 144


                   ....*
gi 1958658528 1266 VTIVS 1270
Cdd:pfam07177  145 VSILG 149
NEUZ smart00588
domain in neuralized proteins;
296-417 1.06e-43

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 154.78  E-value: 1.06e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528   296 DALLFHEKCGTLIKLSNNNKTAerRRPLDEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPAT 375
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVA--RRSASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|..
gi 1958658528   376 MTNLQSGTIMMSGCGILTNGKGTRREYCEFSLDELQEGDHIG 417
Cdd:smart00588   79 PTNACPDLVDMSGFWAKALGEGLAEQGGILGLDVLAEGEVVG 120
NEUZ smart00588
domain in neuralized proteins;
500-622 4.58e-39

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 141.68  E-value: 4.58e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528   500 RLLFHPNCGQKAAITHEGRTALRPHatDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTM 579
Cdd:smart00588    2 PLRFHHRHGSNIRLSDSGRVARRSA--SDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLP 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 1958658528   580 TNLRSGTWMMTGNGVMHNGTTILDEYG-HNLDRLKAGDTVGVVR 622
Cdd:smart00588   80 TNACPDLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 894-1062 7.10e-34

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 127.65  E-value: 7.10e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  894 FHSTCGKNVTLEEDGTRAVRVAGYAHGLVFSTKELKAEEVFEVKVEELDEKWAGSLRLGLTTLAPEDMGPGAgsgpglPP 973
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRPKA------LP 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  974 SLPELRTKTTWMVSSCEvrrdghlqrmnygrnlERLGVGSRVGIRRCADDTMHILVDGEDMGPAATGIAKN--VWAVLDL 1051
Cdd:pfam07177   75 DLATDLRPGYWVVALSG----------------SYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDL 138

                          170
                   ....*....|.
gi 1958658528 1052 YGPVRSVAIVS 1062
Cdd:pfam07177  139 YGQTTQVSILG 149
NEUZ smart00588
domain in neuralized proteins;
696-818 1.74e-33

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 125.89  E-value: 1.74e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528   696 DLRFHQLHGSNAVITNGGRTALRHncRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLEFPNTM 775
Cdd:smart00588    2 PLRFHHRHGSNIRLSDSGRVARRS--ASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLP 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 1958658528   776 TDIDYDTWMLSGTAIMQDGNTMRNNYGC-DLDALGTGARIGMMR 818
Cdd:smart00588   80 TNACPDLVDMSGFWAKALGEGLAEQGGIlGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
47-165 9.70e-30

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 115.10  E-value: 9.70e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528    47 HPRTGRLVSLSACGRTARRQQpgQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVLDFPSSATGLK 126
Cdd:smart00588    6 HHRHGSNIRLSDSGRVARRSA--SDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLPTNAC 83

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 1958658528   127 GGSWVVSGCSVLRDGRSVLEEYG-QDLDQLVEGDRVGVER 165
Cdd:smart00588   84 PDLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
1107-1224 1.94e-14

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 71.19  E-value: 1.94e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  1107 TALEFLENHGKNILLSNGNRTATRVAS-YNQGIVVISQPLVPHMLVQVRIDFLNRQWTSSLVLGVITCPPERLNFPASAC 1185
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVARRSASdFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLPT 80

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 1958658528  1186 ALKRAAWLLRGRGVFHNGLKICEKFGP-NLDTCPEGTILG 1224
Cdd:smart00588   81 NACPDLVDMSGFWAKALGEGLAEQGGIlGLDVLAEGEVVG 120
NEUZ smart00588
domain in neuralized proteins;
893-1019 5.78e-13

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 66.95  E-value: 5.78e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528   893 RFHSTCGKNVTLEEDGTRAVRVAG-YAHGLVFSTKELKAEEVFEVKVEELDEKWAGSLRLGLTTLAPEDMGPgagsgPGL 971
Cdd:smart00588    4 RFHHRHGSNIRLSDSGRVARRSASdFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRP-----ASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*....
gi 1958658528   972 PPSLPElrtkTTWMVSSCEVRRDGHLQRMNYG-RNLERLGVGSRVGIRR 1019
Cdd:smart00588   79 PTNACP----DLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
 
Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 698-860 1.85e-86

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 278.62  E-value: 1.85e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  698 RFHQLHGSNAVITNGGRTALRhnCRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLEFPNTMTD 777
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  778 IDYDTWMLSGTAIMQDGNTMRNNYGCDLDALGTGARIGMMRTAKGDLHYFINGQDQGAACSGLPPEVYAVVDLYGQCVQV 857
Cdd:cd12887     79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                   ...
gi 1958658528  858 SIT 860
Cdd:cd12887    159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 503-664 8.73e-86

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 276.70  E-value: 8.73e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  503 FHPNCGQKAAITHEGRTALRPHatDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTMTNL 582
Cdd:cd12887      2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  583 RSGTWMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVVRREDGTLHFFVNGMTQGPAAWNVPPGVYAVVDLYGQAAQAT 662
Cdd:cd12887     80 KSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVS 159


                   ..
gi 1958658528  663 IV 664
Cdd:cd12887    160 IV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 45-207 3.55e-78

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 255.13  E-value: 3.55e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528   45 ELHPRTGRLVSLSACGRTARRqqPGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVLDFPSSATG 124
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  125 LKGGSWVVSGCSVLRDGRSVLEEYGQDLDQLVEGDRVGVERTATGELRLWVNGRDCGVAATGLPARVWAVVDLYGKCTQI 204
Cdd:cd12887     79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                   ...
gi 1958658528  205 TVL 207
Cdd:cd12887    159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 300-462 1.45e-77

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 253.20  E-value: 1.45e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  300 FHEKCGTLIKLSNNNKTAERRRplDEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPATMTNL 379
Cdd:cd12887      2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  380 QSGTIMMSGCGILTNGKGTRREYCeFSLDELQEGDHIGLTRKSNSALHFFINGIDQGVATPLTPPVVYGVVDLYGMAVKV 459
Cdd:cd12887     80 KSGTWILSGSSVFKNGNKIRENYG-PDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                   ...
gi 1958658528  460 TIV 462
Cdd:cd12887    159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 1110-1269 1.97e-73

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 241.64  E-value: 1.97e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528 1110 EFLENHGKNILLSNGNRTATRVA-SYNQGIVVISQPLVPHMLVQVRIDFLNRQWTSSLVLGVITCPPERLNFPASACALK 1188
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDLK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528 1189 RAAWLLRGRGVFHNGLKICEKFGPNLDTCPEGTILGLRLDSSGGLHLHINGVDQGVAVPDVPQPCHALVDLYGQCEQVTI 1268
Cdd:cd12887     81 SGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVSI 160


                   .
gi 1958658528 1269 V 1269
Cdd:cd12887    161 V 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 893-1061 8.61e-58

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 196.58  E-value: 8.61e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  893 RFHSTCGKNVTLEEDGTRAVRVA-GYAHGLVFSTKELKAEEVFEVKVEELDEKWAGSLRLGLTTLAPEDMGpgagsgpgL 971
Cdd:cd12887      1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLD--------L 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  972 PPSLPELRTKTtWMVSSCEVRRDGHLQRMNYGRNLERLGVGSRVGIRRCADDTMHILVDGEDMGPAATGIAKNVWAVLDL 1051
Cdd:cd12887     73 PPSATDLKSGT-WILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDL 151

                          170
                   ....*....|
gi 1958658528 1052 YGPVRSVAIV 1061
Cdd:cd12887    152 YGQCEQVSIV 161
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 699-861 3.78e-55

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 188.51  E-value: 3.78e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  699 FHQLHGSNAVITNGGRTALRHNcrsEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLE---FPNTM 775
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTN---SFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  776 TDIDYDTWMLSgtaimQDGNTmrnnygcdldaLGTGARIGMMRTAKGDLHYFINGQDQGAACSGLPP--EVYAVVDLYGQ 853
Cdd:pfam07177   78 TDLRPGYWVVA-----LSGSY-----------LQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDsqPLWAVFDLYGQ 141


                   ....*...
gi 1958658528  854 CVQVSITN 861
Cdd:pfam07177  142 TTQVSILG 149
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 300-462 1.70e-54

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 186.97  E-value: 1.70e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  300 FHEKCGTLIKLSNNNKTAERRRpldEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLE---YPATM 376
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTN---SFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  377 TNLQSGTIMMSgcgiltngkgtrreyceFSLDELQEGDHIGLTRKSNSALHFFINGIDQGVATPLTPP--VVYGVVDLYG 454
Cdd:pfam07177   78 TDLRPGYWVVA-----------------LSGSYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDsqPLWAVFDLYG 140


                   ....*...
gi 1958658528  455 MAVKVTIV 462
Cdd:pfam07177  141 QTTQVSIL 148
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 503-665 1.12e-53

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 184.27  E-value: 1.12e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  503 FHPNCGQKAAITHEGRTALRphaTDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQ---LPSTM 579
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARR---TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  580 TNLRSGTWMMtgngvmhngttILDEYghnldRLKAGDTVGVVRREDGTLHFFVNGMTQGPAAWNVPPG--VYAVVDLYGQ 657
Cdd:pfam07177   78 TDLRPGYWVV-----------ALSGS-----YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDLYGQ 141


                   ....*...
gi 1958658528  658 AAQATIVD 665
Cdd:pfam07177  142 TTQVSILG 149
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 47-207 8.47e-51

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 176.19  E-value: 8.47e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528   47 HPRTGRLVSLSACGRTARRqqpGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVL---DFPSSAT 123
Cdd:pfam07177    2 HPVHGKNVRLSNDGRTARR---TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLrpkALPDLAT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  124 GLKGGSWVVSgcsvlRDGRsvleeygqdldQLVEGDRVGVERTATGELRLWVNGRDCGVAATGLP--ARVWAVVDLYGKC 201
Cdd:pfam07177   79 DLRPGYWVVA-----LSGS-----------YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYGQT 142


                   ....*.
gi 1958658528  202 TQITVL 207
Cdd:pfam07177  143 TQVSIL 148
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 1111-1270 7.21e-46

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 161.93  E-value: 7.21e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528 1111 FLENHGKNILLSNGNRTATRVASYNQGIVVISQPLVPHMLVQVRIDFLNRQWTSSLVLGVITCPPERLN---FPASACAL 1187
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLATDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528 1188 KRAAWLlrgrgvfhngLKICEKfgpnldTCPEGTILGLRLDSSGGLHLHINGVDQGVAVPDVP--QPCHALVDLYGQCEQ 1265
Cdd:pfam07177   81 RPGYWV----------VALSGS------YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYGQTTQ 144


                   ....*
gi 1958658528 1266 VTIVS 1270
Cdd:pfam07177  145 VSILG 149
NEUZ smart00588
domain in neuralized proteins;
296-417 1.06e-43

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 154.78  E-value: 1.06e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528   296 DALLFHEKCGTLIKLSNNNKTAerRRPLDEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPAT 375
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVA--RRSASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|..
gi 1958658528   376 MTNLQSGTIMMSGCGILTNGKGTRREYCEFSLDELQEGDHIG 417
Cdd:smart00588   79 PTNACPDLVDMSGFWAKALGEGLAEQGGILGLDVLAEGEVVG 120
NEUZ smart00588
domain in neuralized proteins;
500-622 4.58e-39

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 141.68  E-value: 4.58e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528   500 RLLFHPNCGQKAAITHEGRTALRPHatDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTM 579
Cdd:smart00588    2 PLRFHHRHGSNIRLSDSGRVARRSA--SDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLP 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 1958658528   580 TNLRSGTWMMTGNGVMHNGTTILDEYG-HNLDRLKAGDTVGVVR 622
Cdd:smart00588   80 TNACPDLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 894-1062 7.10e-34

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 127.65  E-value: 7.10e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  894 FHSTCGKNVTLEEDGTRAVRVAGYAHGLVFSTKELKAEEVFEVKVEELDEKWAGSLRLGLTTLAPEDMGPGAgsgpglPP 973
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRPKA------LP 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  974 SLPELRTKTTWMVSSCEvrrdghlqrmnygrnlERLGVGSRVGIRRCADDTMHILVDGEDMGPAATGIAKN--VWAVLDL 1051
Cdd:pfam07177   75 DLATDLRPGYWVVALSG----------------SYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDL 138

                          170
                   ....*....|.
gi 1958658528 1052 YGPVRSVAIVS 1062
Cdd:pfam07177  139 YGQTTQVSILG 149
NEUZ smart00588
domain in neuralized proteins;
696-818 1.74e-33

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 125.89  E-value: 1.74e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528   696 DLRFHQLHGSNAVITNGGRTALRHncRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLEFPNTM 775
Cdd:smart00588    2 PLRFHHRHGSNIRLSDSGRVARRS--ASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLP 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 1958658528   776 TDIDYDTWMLSGTAIMQDGNTMRNNYGC-DLDALGTGARIGMMR 818
Cdd:smart00588   80 TNACPDLVDMSGFWAKALGEGLAEQGGIlGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
47-165 9.70e-30

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 115.10  E-value: 9.70e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528    47 HPRTGRLVSLSACGRTARRQQpgQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVLDFPSSATGLK 126
Cdd:smart00588    6 HHRHGSNIRLSDSGRVARRSA--SDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLPTNAC 83

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 1958658528   127 GGSWVVSGCSVLRDGRSVLEEYG-QDLDQLVEGDRVGVER 165
Cdd:smart00588   84 PDLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
1107-1224 1.94e-14

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 71.19  E-value: 1.94e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  1107 TALEFLENHGKNILLSNGNRTATRVAS-YNQGIVVISQPLVPHMLVQVRIDFLNRQWTSSLVLGVITCPPERLNFPASAC 1185
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVARRSASdFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLPT 80

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 1958658528  1186 ALKRAAWLLRGRGVFHNGLKICEKFGP-NLDTCPEGTILG 1224
Cdd:smart00588   81 NACPDLVDMSGFWAKALGEGLAEQGGIlGLDVLAEGEVVG 120
NEUZ smart00588
domain in neuralized proteins;
893-1019 5.78e-13

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 66.95  E-value: 5.78e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528   893 RFHSTCGKNVTLEEDGTRAVRVAG-YAHGLVFSTKELKAEEVFEVKVEELDEKWAGSLRLGLTTLAPEDMGPgagsgPGL 971
Cdd:smart00588    4 RFHHRHGSNIRLSDSGRVARRSASdFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRP-----ASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*....
gi 1958658528   972 PPSLPElrtkTTWMVSSCEVRRDGHLQRMNYG-RNLERLGVGSRVGIRR 1019
Cdd:smart00588   79 PTNACP----DLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
SPRY cd11709
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ...
 89-207 4.43e-09

SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome.


Pssm-ID: 293931  Cd Length: 118  Bit Score: 55.90  E-value: 4.43e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528   89 FTVRIDrkvNSWSGSIEIGVTalDPSVLDFPSSATGLKGGSWVVSGCSVlRDGRSVLEEYGQDldQLVEGDRVGVER-TA 167
Cdd:cd11709      5 WEVRVD---SGNGGLIQVGWA--TKSFSLDGEGGVGDDEESWGYDGSRL-RKGHGGSSGPGGR--PWKSGDVVGCLLdLD 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958658528  168 TGELRLWVNGRDCGVAATGLPA---RVWAVVDLYGKCtQITVL 207
Cdd:cd11709     77 EGTLSFSLNGKDLGVAFTNLFLkggGLYPAVSLGSGQ-GVTIN 118
SPRY cd11709
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ...
 546-659 1.03e-04

SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome.


Pssm-ID: 293931  Cd Length: 118  Bit Score: 43.19  E-value: 1.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658528  546 FQVRIDKMVDkwaGSIEIGVTTHNPAYLQLPSTMTNLRSgtWMMTGNGVmHNGTTILDEYGhnLDRLKAGDTVGV-VRRE 624
Cdd:cd11709      5 WEVRVDSGNG---GLIQVGWATKSFSLDGEGGVGDDEES--WGYDGSRL-RKGHGGSSGPG--GRPWKSGDVVGClLDLD 76

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1958658528  625 DGTLHFFVNGMTQGPAAWNV---PPGVYAVVDLYGQAA 659
Cdd:cd11709     77 EGTLSFSLNGKDLGVAFTNLflkGGGLYPAVSLGSGQG 114
SPRY_SOCS_Fbox cd12875
SPRY domain in Fbxo45 and suppressors of cytokine signaling (SOCS) proteins; This family ...
 587-658 6.25e-03

SPRY domain in Fbxo45 and suppressors of cytokine signaling (SOCS) proteins; This family consists of the SPRY domain-containing SOCS box protein family (SPSB1-4, also known as SSB-1 to -4) as well as F-box protein 45 (Fbxo45), a novel synaptic E3 and ubiquitin ligase. The SPSB protein is composed of a central SPRY protein interaction domain and a C-terminal SOCS box. SPSB1, SPSB2, and SPSB4 interact with prostate apoptosis response protein 4 (Par-4) and are negative regulators that recruit the ECS E3 ubiquitin ligase complex to polyubiquitinate inducible nitric-oxide synthase (iNOS), resulting in its proteasomal degradation. Fbxo45 is related to this family; it is located N-terminal to the SPRY domain, and known to induce the degradation of a synaptic vesicle-priming factor, Munc13-1, via the SPRY domain, thus playing an important role in the regulation of neurotransmission by modulating Munc13-1 at the synapse. Suppressor of cytokine signaling (SOCS) proteins negatively regulate signaling from JAK-associated cytokine receptor complexes, and play key roles in the regulation of immune homeostasis.


Pssm-ID: 293935  Cd Length: 169  Bit Score: 39.36  E-value: 6.25e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958658528  587 WMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVV-RREDGTLHFFVNGMTQGPAAWNVP-----PGVYAVvdlYGQA 658
Cdd:cd12875     88 WDLGDNKLYHNGKKVIGSYPAKSENYQVPDRILVIlDMEDGTLAFEANGEYLGVAFRGLPgkllyPAVSAV---YGNC 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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