|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
458-1007 |
8.51e-163 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 496.67 E-value: 8.51e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 458 EELIQLKAKERHFLEQLldgkKLENYKIPVPINAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILagdhc 537
Cdd:COG0553 211 LELLAEAAVDAFRLRRL----REALESLPAGLKATLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALL----- 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 538 qraQEYARSKLAEcmplPSLVVCPPTLTGHWVDEVGKFCSReyLNPLHYTGPpTERIRLQHQVKRHNLIVASYDVVRNDI 617
Cdd:COG0553 282 ---LELKERGLAR----PVLIVAPTSLVGNWQRELAKFAPG--LRVLVLDGT-RERAKGANPFEDADLVITSYGLLRRDI 351
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 618 DFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPIL 697
Cdd:COG0553 352 ELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIE 431
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 698 ASRDArsssreqeagvlAMDALHRQVLPFLLRRMKEDVLQDLPPKIIQDYYCTLSPLQVQLYEdfaksrakcdvdeTVSS 777
Cdd:COG0553 432 KGDEE------------ALERLRRLLRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALYE-------------AVLE 486
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 778 AALSEETEKPKLKATGHVFQALQYLRKLCNHPALVLtpqhpefkNTTEKLAVQNsslhdiqhaPKLSALKQLLldcglgn 857
Cdd:COG0553 487 YLRRELEGAEGIRRRGLILAALTRLRQICSHPALLL--------EEGAELSGRS---------AKLEALLELL------- 542
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 858 gtssesgTESVVAQHRILIFCQLKSMLDIVEHDLLKPHLPsvtYLRLDGSIPPGQRHSIVSRFNNDPSIDVLLLTTHVGG 937
Cdd:COG0553 543 -------EELLAEGEKVLVFSQFTDTLDLLEERLEERGIE---YAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGG 612
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 938 LGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQKRVVNVYRLITRGTLEEKIMGLQKFKMNIANTVIS 1007
Cdd:COG0553 613 EGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
493-730 |
9.67e-158 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 466.06 E-value: 9.67e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCQRAQEYarsklaECMPLPSLVVCPPTLTGHWVDEV 572
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILASDHHKRANSF------NSENLPSLVVCPPTLVGHWVAEI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 573 GKFCSREYLNPLHYTGPPTERIRLQHQVKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLTA 652
Cdd:cd17999 75 KKYFPNAFLKPLAYVGPPQERRRLREQGEKHNVIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKA 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958648402 653 NYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAMDALHRQVLPFLLRR 730
Cdd:cd17999 155 NHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPILASRDSKASAKEQEAGALALEALHKQVLPFLLRR 232
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
489-732 |
7.78e-85 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 273.29 E-value: 7.78e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 489 INAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILagdhCQRAQEYarsklaecMPLPSLVVCPPTLTGHW 568
Cdd:cd18012 1 LKATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALL----LSRKEEG--------RKGPSLVVAPTSLIYNW 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 569 VDEVGKFCSReyLNPLHYTGPPTERiRLQHQVKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVK 648
Cdd:cd18012 69 EEEAAKFAPE--LKVLVIHGTKRKR-EKLRALEDYDLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVK 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 649 QLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARsssreqeagvlAMDALHRQVLPFLL 728
Cdd:cd18012 146 ALKADHRLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKDGDEE-----------ALEELKKLISPFIL 214
|
....
gi 1958648402 729 RRMK 732
Cdd:cd18012 215 RRLK 218
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
486-1041 |
2.81e-84 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 295.56 E-value: 2.81e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 486 PVPINAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCQRAqeyarsklaecMPLPSLVVCPPTLT 565
Cdd:PLN03142 163 PSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEYRG-----------ITGPHMVVAPKSTL 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 566 GHWVDEVGKFCSreYLNPLHYTGPPTERirlQHQvkRHNLIVA--------SYDVVRNDIDFFRNIKFNYCILDEGHVIK 637
Cdd:PLN03142 232 GNWMNEIRRFCP--VLRAVKFHGNPEER---AHQ--REELLVAgkfdvcvtSFEMAIKEKTALKRFSWRYIIIDEAHRIK 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 638 NGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGkpilasrdarSSSREQEAGVLAMd 717
Cdd:PLN03142 305 NENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQ----------ISGENDQQEVVQQ- 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 718 aLHRQVLPFLLRRMKEDVLQDLPPKIIQDYYCTLSPLQVQLYedfaKSRAKCDVDetvssaALSEETEKPKLkatghVFQ 797
Cdd:PLN03142 374 -LHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYY----KALLQKDLD------VVNAGGERKRL-----LNI 437
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 798 ALQyLRKLCNHPALV--LTPQHPEFknTTEKLaVQNSSlhdiqhapklsalKQLLLDCGLGNGTSSESgtesvvaqhRIL 875
Cdd:PLN03142 438 AMQ-LRKCCNHPYLFqgAEPGPPYT--TGEHL-VENSG-------------KMVLLDKLLPKLKERDS---------RVL 491
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 876 IFCQLKSMLDIVEHDLLkphLPSVTYLRLDGSIPPGQRHSIVSRFNNDPSID-VLLLTTHVGGLGLNLTGADTVVFVEHD 954
Cdd:PLN03142 492 IFSQMTRLLDILEDYLM---YRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLATADIVILYDSD 568
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 955 WNPMRDLQAMDRAHRIGQKRVVNVYRLITRGTLEEKIMGLQKFKMNIANTVISQ----ENSSLqsmGTDQLLDLFTLDkd 1030
Cdd:PLN03142 569 WNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQgrlaEQKTV---NKDELLQMVRYG-- 643
|
570
....*....|.
gi 1958648402 1031 gkAEKADSSTS 1041
Cdd:PLN03142 644 --AEMVFSSKD 652
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
496-812 |
6.19e-69 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 232.57 E-value: 6.19e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 496 YQQDGVNWLAFL-NKYKLHGILCDDMGLGKTLQSICILAGDHCQRAQeyarsklaecMPLPSLVVCPPTLTGHWVDEVGK 574
Cdd:pfam00176 1 YQIEGVNWMLSLeNNLGRGGILADEMGLGKTLQTISLLLYLKHVDKN----------WGGPTLIVVPLSLLHNWMNEFER 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 575 FCSREYLNPLHYTGPPTERIRLQHQVKR---HNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLT 651
Cdd:pfam00176 71 WVSPPALRVVVLHGNKRPQERWKNDPNFladFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 652 ANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSReqeagvlamdaLHRQVLPFLLRRM 731
Cdd:pfam00176 151 TRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGKKGVSR-----------LHKLLKPFLLRRT 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 732 KEDVLQDLPPKIIQDYYCTLSPLQVQLYEDFAKSRakcDVDETVSSaalseetEKPKLKATGhVFQALQYLRKLCNHPAL 811
Cdd:pfam00176 220 KKDVEKSLPPKVEYILFCRLSKLQRKLYQTFLLKK---DLNAIKTG-------EGGREIKAS-LLNILMRLRKICNHPGL 288
|
.
gi 1958648402 812 V 812
Cdd:pfam00176 289 I 289
|
|
| DUF3535 |
pfam12054 |
Domain of unknown function (DUF3535); This presumed domain is functionally uncharacterized. ... |
1-278 |
4.16e-68 |
|
Domain of unknown function (DUF3535); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 439 to 459 amino acids in length. This domain is found associated with pfam00271, pfam02985, pfam00176. This domain has two completely conserved residues (P and K) that may be functionally important.
Pssm-ID: 463447 Cd Length: 445 Bit Score: 235.60 E-value: 4.16e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 1 MQNECKQFISSLADAHIEVGNRVNN-------------NVLTIDQANDLVTTLFNEVTSTFDLNPQVL--QQLDSKRHQV 65
Cdd:pfam12054 199 LRTQCQQLLNTFRDVGKVSQSKLPKlavvvqgepeagpGAFSIEQAEKLVGEDYDKLKKSLSPKQKLLalQQLEDRRRRV 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 66 QMTVAETNQEWQVLQLRVHTFAACAVVSLQQLPEKLNPIIKPLMETIKKEENTLVQNYAAQYIAKLLQQCTTR-TPCPNS 144
Cdd:pfam12054 279 QAAIEEAKEAKEQRDVRVLAAAAGALVALKGLPKKLNPIIKPLMDSIKKEENEELQQRSADALAHLIDLCVDRgKPGPND 358
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 145 KVIKNLCSSLCVDPYLTPCVtcpvptqsgqenskgsnsekdgmHHTVTKHRGIITLYRHQKAAFAITSrrgpipkaikaq 224
Cdd:pfam12054 359 KIVKNLCTFLCVDTSETPEF-----------------------HPNAKLTDGILTLRKEEDKADHADA------------ 403
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1958648402 225 iadlpagssgnilVELDEGQKPYLVQRRGAEFALTTVVKHFGAEMALKLPHLWD 278
Cdd:pfam12054 404 -------------AKFEEEAKEARIQRRGAKLALEQLAKKFGASLFEKVPKLWE 444
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
493-682 |
1.13e-65 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 218.97 E-value: 1.13e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCQRAQeyarsklaecmPLPSLVVCPPTLTGHWVDEV 572
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKE-----------RGPVLVVCPLSVLENWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 573 GKFCSReyLNPLHYTGPPTERIRLQHQ--VKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQL 650
Cdd:cd17919 70 EKWTPD--LRVVVYHGSQRERAQIRAKekLDKFDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKAL 147
|
170 180 190
....*....|....*....|....*....|..
gi 1958648402 651 TANYRIILSGTPIQNNVLELWSLFDFLMPGFL 682
Cdd:cd17919 148 RAKRRLLLTGTPLQNNLEELWALLDFLDPPFL 179
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
493-730 |
5.11e-60 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 205.30 E-value: 5.11e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHcqraqeyaRSKLAEcmplPSLVVCPPTLTGHWVDEV 572
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMF--------DSGLIK----SVLVVMPTSLIPHWVKEF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 573 GKFCSREYLNpLHYTGPPTERIRLQHQVKR-HNLIVASYDVVRNDIDFF-----RNIKFNYCILDEGHVIKNGKTKLSKA 646
Cdd:cd18001 69 AKWTPGLRVK-VFHGTSKKERERNLERIQRgGGVLLTTYGMVLSNTEQLsaddhDEFKWDYVILDEGHKIKNSKTKSAKS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 647 VKQLTANYRIILSGTPIQNNVLELWSLFDFLMPG-FLGTERQFAARYGKPILASRDARSSSREQEAGVLAMDALHRQVLP 725
Cdd:cd18001 148 LREIPAKNRIILTGTPIQNNLKELWALFDFACNGsLLGTRKTFKMEFENPITRGRDKDATQGEKALGSEVAENLRQIIKP 227
|
....*
gi 1958648402 726 FLLRR 730
Cdd:cd18001 228 YFLRR 232
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
833-982 |
7.13e-54 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 183.83 E-value: 7.13e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 833 SLHDIQHAPKLSALKQLLLDCGLGNgtssesgtesvvaqHRILIFCQLKSMLDIVEHDLLKPHlpsVTYLRLDGSIPPGQ 912
Cdd:cd18793 3 PKIEEVVSGKLEALLELLEELREPG--------------EKVLIFSQFTDTLDILEEALRERG---IKYLRLDGSTSSKE 65
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 913 RHSIVSRFNNDPSIDVLLLTTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQKRVVNVYRLI 982
Cdd:cd18793 66 RQKLVDRFNEDPDIRVFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
493-732 |
5.00e-52 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 182.59 E-value: 5.00e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhCQRAQEyarsklaecMPLPSLVVCPPTLTGHWVDEV 572
Cdd:cd18009 4 MRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLA---HLRERG---------VWGPFLVIAPLSTLPNWVNEF 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 573 GKFCSReyLNPLHYTGPPTERIRLQHQVKRHN-------LIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSK 645
Cdd:cd18009 72 ARFTPS--VPVLLYHGTKEERERLRKKIMKREgtlqdfpVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 646 AVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASR--DARSSSREQEAGVLAMdaLHRQV 723
Cdd:cd18009 150 ELKTFNSDNRLLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFDFSSLSDNaaDISNLSEEREQNIVHM--LHAIL 227
|
....*....
gi 1958648402 724 LPFLLRRMK 732
Cdd:cd18009 228 KPFLLRRLK 236
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
493-730 |
9.52e-50 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 176.42 E-value: 9.52e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILA---------GDHCQRAQEYARSKLAECMPLPSLVVCPPT 563
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAavlgktgtrRDRENNRPRFKKKPPASSAKKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 564 LTGHWVDEVGKFcsrEYLNPLHYTGPPTERIrLQHQVK--RHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKT 641
Cdd:cd18005 81 VLYNWKDELDTW---GHFEVGVYHGSRKDDE-LEGRLKagRLEVVVTTYDTLRRCIDSLNSINWSAVIADEAHRIKNPKS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 642 KLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAMDALHR 721
Cdd:cd18005 157 KLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATARELRLGRKRKQELAV 236
|
....*....
gi 1958648402 722 QVLPFLLRR 730
Cdd:cd18005 237 KLSKFFLRR 245
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
493-730 |
2.28e-49 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 175.17 E-value: 2.28e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWL----AFLNKYKLHG-ILCDDMGLGKTLQSICILAGDHCQRaqEYARSKLAECmplpsLVVCPPTLTGH 567
Cdd:cd18004 1 LRPHQREGVQFLydclTGRRGYGGGGaILADEMGLGKTLQAIALVWTLLKQG--PYGKPTAKKA-----LIVCPSSLVGN 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 568 WVDEVGKFCSREYLNPLHYTG--PPTERIRLQHQV-KRHNLIVASYDVVRNDID-FFRNIKFNYCILDEGHVIKNGKTKL 643
Cdd:cd18004 74 WKAEFDKWLGLRRIKVVTADGnaKDVKASLDFFSSaSTYPVLIISYETLRRHAEkLSKKISIDLLICDEGHRLKNSESKT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 644 SKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAMDALHRQV 723
Cdd:cd18004 154 TKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSQELSELT 233
|
....*..
gi 1958648402 724 LPFLLRR 730
Cdd:cd18004 234 SRFILRR 240
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
493-682 |
3.34e-49 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 172.89 E-value: 3.34e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCqrAQEYARsklaecmplPSLVVCPPTLTGHWVDEV 572
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHH--SKLGLG---------PSLIVCPATVLKQWVKEF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 573 GKFCSREYLNPLHYTGPPT-----------ERIRLQHQVKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKT 641
Cdd:cd18000 70 HRWWPPFRVVVLHSSGSGTgseeklgsierKSQLIRKVVGDGGILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDA 149
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1958648402 642 KLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFL 682
Cdd:cd18000 150 EITLACKQLRTPHRLILSGTPIQNNLKELWSLFDFVFPPYL 190
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
493-730 |
1.06e-47 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 170.55 E-value: 1.06e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLaflnkykLH--GILCDDMGLGKTLQSICILAGDHCQRAQEY----ARSKLAECMPLPS--LVVCPPTL 564
Cdd:cd18008 1 LLPYQKQGLAWM-------LPrgGILADEMGLGKTIQALALILATRPQDPKIPeeleENSSDPKKLYLSKttLIVVPLSL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 565 TGHWVDEVGKFCSREYLNPLHYTGPptERIRLQHQVKRHNLIVASYDVVRNDIDFF----------------RNIKFNYC 628
Cdd:cd18008 74 LSQWKDEIEKHTKPGSLKVYVYHGS--KRIKSIEELSDYDIVITTYGTLASEFPKNkkgggrdskekeasplHRIRWYRV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 629 ILDEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDArsssre 708
Cdd:cd18008 152 ILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPFSKNDRK------ 225
|
250 260
....*....|....*....|..
gi 1958648402 709 qeagvlAMDALHRQVLPFLLRR 730
Cdd:cd18008 226 ------ALERLQALLKPILLRR 241
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
493-730 |
2.63e-45 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 162.91 E-value: 2.63e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCQRaQEYArsklaecmplPSLVVCPPTLTGHWVDEV 572
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEK-GNWG----------PHLIVVPTSVMLNWEMEF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 573 GKFCSReyLNPLHYTGPPTERIRlqhqvKRH--------NLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLS 644
Cdd:cd18003 70 KRWCPG--FKILTYYGSAKERKL-----KRQgwmkpnsfHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRW 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 645 KAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPIlasrDARSSSREQEAGVLaMDALHRQVL 724
Cdd:cd18003 143 QTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPL----TAMSEGSQEENEEL-VRRLHKVLR 217
|
....*.
gi 1958648402 725 PFLLRR 730
Cdd:cd18003 218 PFLLRR 223
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
493-679 |
7.17e-45 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 160.24 E-value: 7.17e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqRAQEYARsklaecmPLPSLVVCPPTLTGHWVDEV 572
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLA-----YLKEIGI-------PGPHLVVVPSSTLDNWLREF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 573 GKFCSReyLNPLHYTGPPTERIRLQHQVKR----HNLIVASYDVV---RNDIDFFRNIKFNYCILDEGHVIKNGKTKLSK 645
Cdd:cd17998 69 KRWCPS--LKVEPYYGSQEERKHLRYDILKgledFDVIVTTYNLAtsnPDDRSFFKRLKLNYVVYDEGHMLKNMTSERYR 146
|
170 180 190
....*....|....*....|....*....|....
gi 1958648402 646 AVKQLTANYRIILSGTPIQNNVLELWSLFDFLMP 679
Cdd:cd17998 147 HLMTINANFRLLLTGTPLQNNLLELMSLLNFIMP 180
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
493-730 |
2.59e-41 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 151.50 E-value: 2.59e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqraqeyarsKLAECMPL--PSLVVCPPTLTGHWVD 570
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLA-------------HLAEEHNIwgPFLVIAPASTLHNWQQ 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 571 EVGKFCSReyLNPLHYTGPPTERIRLQHQVKRHNL---------IVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKT 641
Cdd:cd18002 68 EISRFVPQ--FKVLPYWGNPKDRKVLRKFWDRKNLytrdapfhvVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSS 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 642 KLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEagvlaMDALHR 721
Cdd:cd18002 146 SRWKTLLSFHCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAENKTGLNEHQ-----LKRLHM 220
|
....*....
gi 1958648402 722 QVLPFLLRR 730
Cdd:cd18002 221 ILKPFMLRR 229
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
490-732 |
2.78e-41 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 151.32 E-value: 2.78e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 490 NAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqraqeYArsKLAECMPLPSLVVCPPTLTGHWV 569
Cdd:cd17997 1 GGTMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLG---------YL--KHYKNINGPHLIIVPKSTLDNWM 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 570 DEVGKFCSReyLNPLHYTGPPTER---IRLQHQVKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKA 646
Cdd:cd17997 70 REFKRWCPS--LRVVVLIGDKEERadiIRDVLLPGKFDVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQI 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 647 VKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYgkpilaSRDARSSSREQeagvlAMDALHRQVLPF 726
Cdd:cd17997 148 VRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWF------NVNNCDDDNQE-----VVQRLHKVLRPF 216
|
....*.
gi 1958648402 727 LLRRMK 732
Cdd:cd17997 217 LLRRIK 222
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
493-730 |
2.95e-41 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 151.25 E-value: 2.95e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFlNKYKLHG-ILCDDMGLGKTLQSICILagdhcqraqEYARSKlaECMPLPSLVVCPPTLTGHWVDE 571
Cdd:cd17995 1 LRDYQLEGVNWLLF-NWYNRRNcILADEMGLGKTIQSIAFL---------EHLYQV--EGIRGPFLVIAPLSTIPNWQRE 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 572 VGKFCSreyLNPLHYTGPPTER-IRLQHQ-------------VKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIK 637
Cdd:cd17995 69 FETWTD---MNVVVYHGSGESRqIIQQYEmyfkdaqgrkkkgVYKFDVLITTYEMVIADAEELRKIPWRVVVVDEAHRLK 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 638 NGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGkpilasrDARSSSREQEagvlamd 717
Cdd:cd17995 146 NRNSKLLQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEFG-------DLKTAEQVEK------- 211
|
250
....*....|...
gi 1958648402 718 aLHRQVLPFLLRR 730
Cdd:cd17995 212 -LQALLKPYMLRR 223
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
493-730 |
4.18e-41 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 150.67 E-value: 4.18e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqraqeYARSKLAecMPLPSLVVCPPTLTGHWVDEV 572
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLW---------YLAGRLK--LLGPFLVLCPLSVLDNWKEEL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 573 GKFCSReyLNPLHYTGPPTERIRLQHQVK---RHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQ 649
Cdd:cd18006 70 NRFAPD--LSVITYMGDKEKRLDLQQDIKstnRFHVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 650 LTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTER--QFAARYgkpilasrdarsssREQEAGVLAMDALHRQVLPFL 727
Cdd:cd18006 148 FSVDFRLLLTGTPIQNSLQELYALLSFIEPNVFPKDKldDFIKAY--------------SETDDESETVEELHLLLQPFL 213
|
...
gi 1958648402 728 LRR 730
Cdd:cd18006 214 LRR 216
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
490-732 |
5.86e-41 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 150.60 E-value: 5.86e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 490 NAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqraqeYarskLAECMPL--PSLVVCP-PTLTG 566
Cdd:cd17996 1 GGTLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLIT---------Y----LMEKKKNngPYLVIVPlSTLSN 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 567 hWVDEVGKFCSReyLNPLHYTGPPTERIRLQHQVK--RHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLS 644
Cdd:cd17996 68 -WVSEFEKWAPS--VSKIVYKGTPDVRKKLQSQIRagKFNVLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLT 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 645 KAVKQ-LTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAMDALHRQV 723
Cdd:cd17996 145 QTLNTyYHARYRLLLTGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFANTGEQVKIELNEEETLLIIRRLHKVL 224
|
....*....
gi 1958648402 724 LPFLLRRMK 732
Cdd:cd17996 225 RPFLLRRLK 233
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
492-730 |
1.37e-40 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 149.04 E-value: 1.37e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 492 ELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdHCQRAQEyarsklaecMPLPSLVVCPPTLTGHWVDE 571
Cdd:cd17993 1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLS--YLFHSQQ---------QYGPFLVVVPLSTMPAWQRE 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 572 VGKFCSReyLNPLHYTGPPTER--IR----LQHQVKR--HNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKL 643
Cdd:cd17993 70 FAKWAPD--MNVIVYLGDIKSRdtIReyefYFSQTKKlkFNVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 644 SKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKpilasrdarsssrEQEAGVlamDALHRQV 723
Cdd:cd17993 148 YEALKEFKTNNRLLITGTPLQNSLKELWALLHFLMPGKFDIWEEFEEEHDE-------------EQEKGI---ADLHKEL 211
|
....*..
gi 1958648402 724 LPFLLRR 730
Cdd:cd17993 212 EPFILRR 218
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
491-742 |
2.50e-36 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 137.87 E-value: 2.50e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 491 AELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqrAQEYARSklaecMPLPSLVVCPPTLTGHWVD 570
Cdd:cd18064 14 GKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLG------YMKHYRN-----IPGPHMVLVPKSTLHNWMA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 571 EVGKFCSReyLNPLHYTGPPTERIRLQHQV---KRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAV 647
Cdd:cd18064 83 EFKRWVPT--LRAVCLIGDKDQRAAFVRDVllpGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 648 KQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYgkpilasrDARSSSREQEagvlAMDALHRQVLPFL 727
Cdd:cd18064 161 REFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWF--------DTNNCLGDQK----LVERLHMVLRPFL 228
|
250
....*....|....*
gi 1958648402 728 LRRMKEDVLQDLPPK 742
Cdd:cd18064 229 LRRIKADVEKSLPPK 243
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
493-730 |
1.96e-33 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 129.51 E-value: 1.96e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWL----AFLNKYKLHG-ILCDDMGLGKTLQSICIL-----AGDHCQRAQEYArsklaecmplpsLVVCPP 562
Cdd:cd18067 1 LRPHQREGVKFLyrcvTGRRIRGSHGcIMADEMGLGKTLQCITLMwtllrQSPQCKPEIDKA------------IVVSPS 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 563 TLTGHWVDEVGKFCSREyLNPLHYTGPPTERIRLQ---------HQVKRHNLIVaSYDVVRNDIDFFRNIKFNYCILDEG 633
Cdd:cd18067 69 SLVKNWANELGKWLGGR-LQPLAIDGGSKKEIDRKlvqwasqqgRRVSTPVLII-SYETFRLHVEVLQKGEVGLVICDEG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 634 HVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGV 713
Cdd:cd18067 147 HRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILKGRDADASEKERQLGE 226
|
250
....*....|....*..
gi 1958648402 714 LAMDALHRQVLPFLLRR 730
Cdd:cd18067 227 EKLQELISIVNRCIIRR 243
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
489-732 |
3.43e-33 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 129.03 E-value: 3.43e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 489 INAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqRAQEYARsklaecMPLPSLVVCPPTLTGHW 568
Cdd:cd18063 20 INGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALIT-----YLMEHKR------LNGPYLIIVPLSTLSNW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 569 VDEVGKFCSReyLNPLHYTGPPTERIRLQHQVK--RHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKA 646
Cdd:cd18063 89 TYEFDKWAPS--VVKISYKGTPAMRRSLVPQLRsgKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 647 VK-QLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPiLASRDARSSSREQEAgVLAMDALHRQVLP 725
Cdd:cd18063 167 LNtHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAP-FAMTGERVDLNEEET-ILIIRRLHKVLRP 244
|
....*..
gi 1958648402 726 FLLRRMK 732
Cdd:cd18063 245 FLLRRLK 251
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
493-677 |
1.27e-32 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 127.21 E-value: 1.27e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLHG-ILCDDMGLGKTLQSIC-ILAGDHCQRAQEYAR--------SKLAECMpLPS---LVV 559
Cdd:cd18072 1 LLLHQKQALAWLLWRERQKPRGgILADDMGLGKTLTMIAlILAQKNTQNRKEEEKekalteweSKKDSTL-VPSagtLVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 560 CPPTLTGHWVDEVGKFCSREYLNPLHYTGPptERIRLQHQVKRHNLIVASYDVVRNDIDFFRN---------IKFNYCIL 630
Cdd:cd18072 80 CPASLVHQWKNEVESRVASNKLRVCLYHGP--NRERIGEVLRDYDIVITTYSLVAKEIPTYKEesrssplfrIAWARIIL 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1958648402 631 DEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFL 677
Cdd:cd18072 158 DEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFL 204
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
515-710 |
1.48e-32 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 126.64 E-value: 1.48e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 515 ILCDDMGLGKTLQSICILagdhcqraQEYARSKLAECMPLpslVVCPPTLTGHWVDEVGKFCSREYLNPLHYTGPPTERI 594
Cdd:cd18007 30 ILAHTMGLGKTLQVITFL--------HTYLAAAPRRSRPL---VLCPASTLYNWEDEFKKWLPPDLRPLLVLVSLSASKR 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 595 RLQHQV------KRHNLIVASYDVVRNDI-----------DFFRNIKFNYC---ILDEGHVIKNGKTKLSKAVKQLTANY 654
Cdd:cd18007 99 ADARLRkinkwhKEGGVLLIGYELFRNLAsnattdprlkqEFIAALLDPGPdllVLDEGHRLKNEKSQLSKALSKVKTKR 178
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1958648402 655 RIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQE 710
Cdd:cd18007 179 RILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKPIEAGQCVDSTEEDVR 234
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
493-730 |
2.65e-32 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 125.73 E-value: 2.65e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLH-----GILCDDMGLGKTLQSICILAGDHCQraQEYARSKLAEcmplPSLVVCPPTLTGH 567
Cdd:cd18066 1 LRPHQREGIEFLYECVMGMRVnerfgAILADEMGLGKTLQCISLIWTLLRQ--GPYGGKPVIK----RALIVTPGSLVKN 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 568 WVDEVGKFCSREylnplhytgppteRIRL-----QHQVKR------HNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVI 636
Cdd:cd18066 75 WKKEFQKWLGSE-------------RIKVftvdqDHKVEEfiasplYSVLIISYEMLLRSLDQISKLNFDLVICDEGHRL 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 637 KNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAM 716
Cdd:cd18066 142 KNTSIKTTTALTSLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREPTATPEEKKLGEARA 221
|
250
....*....|....
gi 1958648402 717 DALHRQVLPFLLRR 730
Cdd:cd18066 222 AELTRLTGLFILRR 235
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
489-732 |
5.38e-32 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 125.54 E-value: 5.38e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 489 INAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqRAQEYARsklaecMPLPSLVVCPPTLTGHW 568
Cdd:cd18062 20 VNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALIT-----YLMEHKR------INGPFLIIVPLSTLSNW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 569 VDEVGKFCSReyLNPLHYTGPPTERIRLQHQVK--RHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKA 646
Cdd:cd18062 89 VYEFDKWAPS--VVKVSYKGSPAARRAFVPQLRsgKFNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCKLTQV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 647 VK-QLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASrdARSSSREQEAGVLAMDALHRQVLP 725
Cdd:cd18062 167 LNtHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT--GEKVDLNEEETILIIRRLHKVLRP 244
|
....*..
gi 1958648402 726 FLLRRMK 732
Cdd:cd18062 245 FLLRRLK 251
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
493-732 |
1.06e-31 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 123.97 E-value: 1.06e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqraqeyaRSKLAECMPLPSLVVCPPTLTGHWVDEV 572
Cdd:cd18065 16 LRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLG-----------YLKHYRNIPGPHMVLVPKSTLHNWMNEF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 573 GKFCSReyLNPLHYTGPPTER---IRLQHQVKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQ 649
Cdd:cd18065 85 KRWVPS--LRAVCLIGDKDARaafIRDVMMPGEWDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVRE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 650 LTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYgkpilasrDARSSSREQEagvlAMDALHRQVLPFLLR 729
Cdd:cd18065 163 FKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWF--------DTKNCLGDQK----LVERLHAVLKPFLLR 230
|
...
gi 1958648402 730 RMK 732
Cdd:cd18065 231 RIK 233
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
493-710 |
1.46e-31 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 123.08 E-value: 1.46e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWlAFLNKYKLhgILCDDMGLGKTLQSICILAgdhcqraqeYARsklAECmplPSLVVCPPTLTGHWVDEV 572
Cdd:cd18010 1 LLPFQREGVCF-ALRRGGRV--LIADEMGLGKTVQAIAIAA---------YYR---EEW---PLLIVCPSSLRLTWADEI 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 573 GKFCSREYLNPLHYTGPPTERIR-LQHQVkrhnLIVaSYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLT 651
Cdd:cd18010 63 ERWLPSLPPDDIQVIVKSKDGLRdGDAKV----VIV-SYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPLL 137
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958648402 652 --ANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASR--DARSSSREQE 710
Cdd:cd18010 138 krAKRVILLSGTPALSRPIELFTQLDALDPKLFGRFHDFGRRYCAAKQGGFgwDYSGSSNLEE 200
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
490-730 |
1.49e-30 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 120.88 E-value: 1.49e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 490 NAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCQRaQEYArsklaecmplPSLVVCPPTLTGHWV 569
Cdd:cd18054 18 NLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQH-QLYG----------PFLLVVPLSTLTSWQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 570 DE-------------VGKFCSREYLNPLHYTGPPTERIRLqhqvkrhNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVI 636
Cdd:cd18054 87 REfeiwapeinvvvyIGDLMSRNTIREYEWIHSQTKRLKF-------NALITTYEILLKDKTVLGSINWAFLGVDEAHRL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 637 KNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKpilasrdarssSREQeagvlAM 716
Cdd:cd18054 160 KNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGK-----------GREN-----GY 223
|
250
....*....|....
gi 1958648402 717 DALHRQVLPFLLRR 730
Cdd:cd18054 224 QSLHKVLEPFLLRR 237
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
514-730 |
5.28e-30 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 119.50 E-value: 5.28e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 514 GILCDDMGLGKTLQSICILAGDhcqraqeyarsklaecmplPSLVVCPPTLTGHWVDEVGKFCSREYLNPLHYTGPptER 593
Cdd:cd18071 51 GILADDMGLGKTLTTISLILAN-------------------FTLIVCPLSVLSNWETQFEEHVKPGQLKVYTYHGG--ER 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 594 IRLQHQVKRHNLIVASYDVVRNDIDF-----FRNIKFNYCILDEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVL 668
Cdd:cd18071 110 NRDPKLLSKYDIVLTTYNTLASDFGAkgdspLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPK 189
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958648402 669 ELWSLFDFLMPGFLGTERQFAARYGKPIlasrdarssSREQEAGVLAMDALHRQVlpfLLRR 730
Cdd:cd18071 190 DLGSLLSFLHLKPFSNPEYWRRLIQRPL---------TMGDPTGLKRLQVLMKQI---TLRR 239
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
492-730 |
8.82e-28 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 112.84 E-value: 8.82e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 492 ELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILaGDHCQRAQEYArsklaecmplPSLVVCPPTLTGHWVDE 571
Cdd:cd18053 20 ELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFL-NYLFHEHQLYG----------PFLLVVPLSTLTSWQRE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 572 V-------------GKFCSREYLNPLHYTGPPTERIRLqhqvkrhNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKN 638
Cdd:cd18053 89 IqtwapqmnavvylGDINSRNMIRTHEWMHPQTKRLKF-------NILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 639 GKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKpilaSRDARSSSreqeagvlamda 718
Cdd:cd18053 162 DDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGK----GREYGYAS------------ 225
|
250
....*....|..
gi 1958648402 719 LHRQVLPFLLRR 730
Cdd:cd18053 226 LHKELEPFLLRR 237
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
493-679 |
6.09e-26 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 108.20 E-value: 6.09e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNkyklhGILCDDMGLGKTLQSI-CILAGDHCQRAQE--YARSKLAECMPLP-----------SLV 558
Cdd:cd18070 1 LLPYQRRAVNWMLVPG-----GILADEMGLGKTVEVLaLILLHPRPDNDLDaaDDDSDEMVCCPDClvaetpvsskaTLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 559 VCPPTLTGHWVDEVGKFcSREYLNPLHYTGPPTE---RIRLQHQVKRHNLIVASYDVVRNDIDF---FRN---------- 622
Cdd:cd18070 76 VCPSAILAQWLDEINRH-VPSSLKVLTYQGVKKDgalASPAPEILAEYDIVVTTYDVLRTELHYaeaNRSnrrrrrqkry 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958648402 623 ---------IKFNYCILDEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMP 679
Cdd:cd18070 155 eappsplvlVEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLGV 220
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
514-708 |
4.15e-25 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 105.36 E-value: 4.15e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 514 GILCDDMGLGKTLQSICILagdH----CQRAQEYARSklaecmplpsLVVCPPTLTGHWVDEVGKFcsREYLNPLH---- 585
Cdd:cd18068 31 CILAHCMGLGKTLQVVTFL---HtvllCEKLENFSRV----------LVVCPLNTVLNWLNEFEKW--QEGLKDEEkiev 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 586 -----YTGPPTERIRLQHQVKRHNLIVASYDVVRNdIDFFRNIKF-----------------NYCILDEGHVIKNGKTKL 643
Cdd:cd18068 96 nelatYKRPQERSYKLQRWQEEGGVMIIGYDMYRI-LAQERNVKSreklkeifnkalvdpgpDFVVCDEGHILKNEASAV 174
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958648402 644 SKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSRE 708
Cdd:cd18068 175 SKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQNGQCADSTLVD 239
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
493-730 |
5.52e-25 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 104.37 E-value: 5.52e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILagdhcqraQEYARSKLAEcmplPSLVVCPPTLTGHWVDEV 572
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFL--------QEVYNVGIHG----PFLVIAPLSTITNWEREF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 573 GKFCSreyLNPLHYTGPPTERIRLQHQ--------------VKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKN 638
Cdd:cd18060 69 NTWTE---MNTIVYHGSLASRQMIQQYemyckdsrgrlipgAYKFDALITTFEMILSDCPELREIEWRCVIIDEAHRLKN 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 639 GKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGkpilasrDARSSSREQEagvlamda 718
Cdd:cd18060 146 RNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFG-------DLKTEEQVQK-------- 210
|
250
....*....|..
gi 1958648402 719 LHRQVLPFLLRR 730
Cdd:cd18060 211 LQAILKPMMLRR 222
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
492-686 |
3.67e-24 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 101.41 E-value: 3.67e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 492 ELRKYQQDGVNWLAFLNKyklHGILCDDMGLGKTLQsicilagdhcqrAQEYARSKLAECMPLPSLVVCP-PTLTGHWVD 570
Cdd:smart00487 8 PLRPYQKEAIEALLSGLR---DVILAAPTGSGKTLA------------ALLPALEALKRGKGGRVLVLVPtRELAEQWAE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 571 EVGKFCSREYLNPLHYTGPPTERIRLQHQVKRH-NLIVASYDVVRNDI--DFFRNIKFNYCILDEGHVIKNG--KTKLSK 645
Cdd:smart00487 73 ELKKLGPSLGLKVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLenDKLSLSNVDLVILDEAHRLLDGgfGDQLEK 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1958648402 646 AVKQL-TANYRIILSGTP---IQNNVLELWSLFDFLMPGFLGTER 686
Cdd:smart00487 153 LLKLLpKNVQLLLLSATPpeeIENLLELFLNDPVFIDVGFTPLEP 197
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
493-693 |
2.56e-23 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 99.72 E-value: 2.56e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFlNKYKLHG-ILCDDMGLGKTLQSICILAGDHCQRAQEyarsklaecmplPSLVVCPPTLTGHWVDE 571
Cdd:cd18059 1 LREYQLEGVNWLLF-NWYNTRNcILADEMGLGKTIQSITFLYEIYLKGIHG------------PFLVIAPLSTIPNWERE 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 572 vgkFCSREYLNPLHYTGPPTERIRLQ--------------HQVKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIK 637
Cdd:cd18059 68 ---FRTWTELNVVVYHGSQASRRTIQlyemyfkdpqgrviKGSYKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLK 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1958648402 638 NGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYG 693
Cdd:cd18059 145 NRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFG 200
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
493-693 |
1.61e-22 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 97.42 E-value: 1.61e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqraQEYARSklaecMPLPSLVVCPPTLTGHWVDEv 572
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLS-------EIFLMG-----IRGPFLIIAPLSTITNWERE- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 573 gkFCSREYLNPLHYTGPPTERIRLQHQ--------------VKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKN 638
Cdd:cd18058 68 --FRTWTEMNAIVYHGSQISRQMIQQYemyyrdeqgnplsgIFKFQVVITTFEMILADCPELKKINWSCVIIDEAHRLKN 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1958648402 639 GKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYG 693
Cdd:cd18058 146 RNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFG 200
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
872-971 |
8.71e-22 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 91.12 E-value: 8.71e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 872 HRILIFCQLKSMLDIvehDLLKpHLPSVTYLRLDGSIPPGQRHSIVSRFNNDpSIDVLLlTTHVGGLGLNLTGADTVVFV 951
Cdd:pfam00271 16 GKVLIFSQTKKTLEA---ELLL-EKEGIKVARLHGDLSQEEREEILEDFRKG-KIDVLV-ATDVAERGLDLPDVDLVINY 89
|
90 100
....*....|....*....|
gi 1958648402 952 EHDWNPMRDLQAMDRAHRIG 971
Cdd:pfam00271 90 DLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
515-697 |
4.97e-21 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 92.96 E-value: 4.97e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 515 ILCDDMGLGKTLQSICILagdhcqraqeyarSKLAECMPLPS-LVVCPPTLTGHWVDEVGKFCSREYLNPLhyTGPPTER 593
Cdd:cd18069 32 ILAHSMGLGKTLQVISFL-------------DVLLRHTGAKTvLAIVPVNTLQNWLSEFNKWLPPPEALPN--VRPRPFK 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 594 IRLQHQVkrHNLIVASYDVVRN----------DIDFFRNIKF-NYCILDEGHVIKNGKTKLSKAVKQLTANYRIILSGTP 662
Cdd:cd18069 97 VFILNDE--HKTTAARAKVIEDwvkdggvllmGYEMFRLRPGpDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYP 174
|
170 180 190
....*....|....*....|....*....|....*
gi 1958648402 663 IQNNVLELWSLFDFLMPGFLGTERQFAARYGKPIL 697
Cdd:cd18069 175 LQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPIL 209
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
493-693 |
8.58e-21 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 92.38 E-value: 8.58e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILagdhcqraQEYARSKLAEcmplPSLVVCPPTLTGHWVDEv 572
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFL--------YEILLTGIRG----PFLIIAPLSTIANWERE- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 573 gkFCSREYLNPLHYTGPPTERIRLQHQ--------------VKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKN 638
Cdd:cd18061 68 --FRTWTDLNVVVYHGSLISRQMIQQYemyfrdsqgriirgAYRFQAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKN 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1958648402 639 GKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYG 693
Cdd:cd18061 146 KNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFG 200
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
493-730 |
1.23e-20 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 90.96 E-value: 1.23e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILagdhcqraqeYARSKLAECMPlPSLVVCPPTLTGHWVDEV 572
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFL----------YSLYKEGHSKG-PFLVSAPLSTIINWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 573 GKFCSREYLnpLHYTGppterirlqhqvkrHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLTA 652
Cdd:cd17994 70 EMWAPDFYV--VTYVG--------------DHVLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKI 133
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958648402 653 NYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYgkpilasrdARSSSREQeagvlaMDALHRQVLPFLLRR 730
Cdd:cd17994 134 GYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLQGFLEEF---------ADISKEDQ------IKKLHDLLGPHMLRR 196
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
493-730 |
9.06e-19 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 86.60 E-value: 9.06e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILagdhcqraqeYARSKLAECMPlPSLVVCPPTLTGHWVDEV 572
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFL----------YSLYKEGHTKG-PFLVSAPLSTIINWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 573 GKFCSREYLnpLHYTGPPTER-----------------------IRLQHQVKRHnLIVASYDVVRNDIDFFRNIKFNYCI 629
Cdd:cd18055 70 QMWAPDFYV--VTYTGDKDSRaiirenefsfddnavkggkkafkMKREAQVKFH-VLLTSYELVTIDQAALGSIRWACLV 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 630 LDEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYgkpilasrdARSSSREQ 709
Cdd:cd18055 147 VDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEF---------ADISKEDQ 217
|
250 260
....*....|....*....|.
gi 1958648402 710 eagvlaMDALHRQVLPFLLRR 730
Cdd:cd18055 218 ------IKKLHDLLGPHMLRR 232
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
493-730 |
2.81e-18 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 85.12 E-value: 2.81e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILagdhcqraqeYARSKLAECMPlPSLVVCPPTLTGHWVDE- 571
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFL----------YSLYKEGHSKG-PYLVSAPLSTIINWEREf 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 572 ------------VGKFCSREYLNPLHY--------TGPPTERIRLQHQVKRHnLIVASYDVVRNDIDFFRNIKFNYCILD 631
Cdd:cd18057 70 emwapdfyvvtyTGDKESRSVIRENEFsfednairSGKKVFRMKKEAQIKFH-VLLTSYELITIDQAILGSIEWACLVVD 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 632 EGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYgkpilasrdARSSSREQea 711
Cdd:cd18057 149 EAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEF---------ADISKEDQ-- 217
|
250
....*....|....*....
gi 1958648402 712 gvlaMDALHRQVLPFLLRR 730
Cdd:cd18057 218 ----IKKLHDLLGPHMLRR 232
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
885-971 |
4.99e-18 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 79.56 E-value: 4.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 885 DIVEHDLLKPHLPsvtYLRLDGSIPPGQRHSIVSRFNNDPSidVLLLTTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAM 964
Cdd:smart00490 1 EELAELLKELGIK---VARLHGGLSQEEREEILDKFNNGKI--KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRI 75
|
....*..
gi 1958648402 965 DRAHRIG 971
Cdd:smart00490 76 GRAGRAG 82
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
493-679 |
7.27e-18 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 83.96 E-value: 7.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILagdHCQRAQEYARSKLAECMPLPSLV-------VCPPTLt 565
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFL---YSLYKEGHSKGPFLVSAPLSTIInwerefeMWAPDM- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 566 gHWVDEVGKFCSREYLNPLHYT--------GPPTERIRLQHQVKRHnLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIK 637
Cdd:cd18056 77 -YVVTYVGDKDSRAIIRENEFSfednairgGKKASRMKKEASVKFH-VLLTSYELITIDMAILGSIDWACLIVDEAHRLK 154
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1958648402 638 NGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMP 679
Cdd:cd18056 155 NNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTP 196
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
493-681 |
1.26e-15 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 76.94 E-value: 1.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVnwLAFLNKYKLHGILCDDMGLGKTLQSICIlagdhcqrAQEYARSKLAEcmplPSLVVCPPTLTGHWVDEV 572
Cdd:cd18011 1 PLPHQIDAV--LRALRKPPVRLLLADEVGLGKTIEAGLI--------IKELLLRGDAK----RVLILCPASLVEQWQDEL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 573 GKfcsREYLNPLHYTGPPTERIRLQHQV--KRHNLIVASYDVVRNDI---DFFRNIKFNYCILDEGHVIKNG----KTKL 643
Cdd:cd18011 67 QD---KFGLPFLILDRETAAQLRRLIGNpfEEFPIVIVSLDLLKRSEerrGLLLSEEWDLVVVDEAHKLRNSgggkETKR 143
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1958648402 644 SKAVKQLTAN--YRIILSGTPIQNNVLELWSLFDFLMPGF 681
Cdd:cd18011 144 YKLGRLLAKRarHVLLLTATPHNGKEEDFRALLSLLDPGR 183
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
493-662 |
6.56e-09 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 55.77 E-value: 6.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGV-NWLAFLNKYklHGILCDDMGLGKTLQSICILAgdhcqraqeyarsklaECMPLPSLVVCPPT-LTGHWVD 570
Cdd:cd17926 1 LRPYQEEALeAWLAHKNNR--RGILVLPTGSGKTLTALALIA----------------YLKELRTLIVVPTDaLLDQWKE 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 571 EVGKFCSREYLNPLhyTGPPTERIRLQhqvkrhNLIVASYDVVRNDI----DFFRniKFNYCILDEGHVIkNGKTkLSKA 646
Cdd:cd17926 63 RFEDFLGDSSIGLI--GGGKKKDFDDA------NVVVATYQSLSNLAeeekDLFD--QFGLLIVDEAHHL-PAKT-FSEI 130
|
170
....*....|....*.
gi 1958648402 647 VKQLTANYRIILSGTP 662
Cdd:cd17926 131 LKELNAKYRLGLTATP 146
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
493-696 |
1.23e-08 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 56.59 E-value: 1.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 493 LRKYQQDGVNwlaFLNKYKLHGILCDdMGLGKTLQSICILAGDHcqraqeyarsklAECMPLPSLVVCPPTLTGH-WVDE 571
Cdd:cd18013 1 PHPYQKVAIN---FIIEHPYCGLFLD-MGLGKTVTTLTALSDLQ------------LDDFTRRVLVIAPLRVARStWPDE 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 572 VGKFcsrEYLNPLHY---TGPPTERIRLQHqvKRHNLIVASYDVVrNDIDFFRNIKFNY--CILDEGHVIKNGKTKLSKA 646
Cdd:cd18013 65 VEKW---NHLRNLTVsvaVGTERQRSKAAN--TPADLYVINRENL-KWLVNKSGDPWPFdmVVIDELSSFKSPRSKRFKA 138
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1958648402 647 VKQL--TANYRIILSGTPIQNNVLELWSLFDFLMPGflgtER------QFAARYGKPI 696
Cdd:cd18013 139 LRKVrpVIKRLIGLTGTPSPNGLMDLWAQIALLDQG----ERlgrsitAYRERWFDPD 192
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
828-1065 |
1.51e-08 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 58.97 E-value: 1.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 828 AVQNSSLHDIQHaPKLSALKQLLLDCGLGNGTSsesgtesvvaqhRILIFCQLKSMLD-IVEHdLLKPHLPSVTYLrldg 906
Cdd:COG1111 323 AMRLAEEADIEH-PKLSKLREILKEQLGTNPDS------------RIIVFTQYRDTAEmIVEF-LSEPGIKAGRFV---- 384
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 907 sippGQ-------------RHSIVSRFNNDpSIDVLLlTTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQK 973
Cdd:COG1111 385 ----GQaskegdkgltqkeQIEILERFRAG-EFNVLV-ATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQRKGRTGRKREG 458
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 974 RVVnVyrLITRGTLEEKI--MGLQKFK------MNIANTVISQENSSLQSMGTDQLLDLFT---LDKDGKAEKADSSTSG 1042
Cdd:COG1111 459 RVV-V--LIAKGTRDEAYywSSRRKEKkmksilKKLKKLLDKQEKEKLKESAQATLDEFESikeLAEDEINEKDLDEIES 535
|
250 260
....*....|....*....|....*..
gi 1958648402 1043 KASMKSV----LENLSDLWDAEQYDSE 1065
Cdd:COG1111 536 SENGAHVdwrePVLLQVIVSTLAESLE 562
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
492-662 |
4.17e-06 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 50.79 E-value: 4.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 492 ELRKYQQDGVN-WLAFLNKYKLHGILCDDMGLGKTLqsicILAGDhcqrAQEYARSKLAecmplpsLVVCP-PTLTGHWV 569
Cdd:COG1061 80 ELRPYQQEALEaLLAALERGGGRGLVVAPTGTGKTV----LALAL----AAELLRGKRV-------LVLVPrRELLEQWA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648402 570 DEVgkfcsREYLNPLHYTGPPTERirlqhqvkRHNLIVASYDVVRND--IDFFRNiKFNYCILDEGHVIknGKTKLSKAV 647
Cdd:COG1061 145 EEL-----RRFLGDPLAGGGKKDS--------DAPITVATYQSLARRahLDELGD-RFGLVIIDEAHHA--GAPSYRRIL 208
|
170
....*....|....*
gi 1958648402 648 KQLTANYRIILSGTP 662
Cdd:COG1061 209 EAFPAAYRLGLTATP 223
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
929-973 |
1.84e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 38.07 E-value: 1.84e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1958648402 929 LLLTTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQK 973
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKD 69
|
|
| |
