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Conserved domains on  [gi|1958657810|ref|XP_038941675|]
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microtubule-associated protein tau isoform X15 [Rattus norvegicus]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 321-350 5.36e-14

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.51  E-value: 5.36e-14
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958657810 321 VQIINKKLDLSNVQSKCGSKDNIKHVPGGG 350
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 37-300 3.94e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 65.73  E-value: 3.94e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810   37 PQPPADDGSEEPGSETSDAKSTPTAEAEEAGIGDTPNMEDQAAGHVTQARVAgvskdrtgndekkAKTSTPSCAKTPSNR 116
Cdd:PHA03247  2616 PLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA-------------RRLGRAAQASSPPQR 2682

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  117 PCLSPTRPTPGSSDPLIKPSSPAVCPEPAtsPKYVSSVTPRNGSPGTKQMKLKgADGKTGAKIATPRGAATPGqkGTSNA 196
Cdd:PHA03247  2683 PRRRAARPTVGSLTSLADPPPPPPTPEPA--PHALVSATPLPPGPAAARQASP-ALPAAPAPPAVPAGPATPG--GPARP 2757

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  197 TRIPAKTTPSPKTPPGSASKQPQRKLPP------AGAKTERGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTPPTREPk 270
Cdd:PHA03247  2758 ARPPTTAGPPAPAPPAAPAAGPPRRLTRpavaslSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP- 2836

                          250       260       270
                   ....*....|....*....|....*....|
gi 1958657810  271 kvaVVRTPPKSPSASKSRLQTAPVPMPDLK 300
Cdd:PHA03247  2837 ---TAPPPPPGPPPPSLPLGGSVAPGGDVR 2863
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 352-381 2.59e-10

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 55.11  E-value: 2.59e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958657810 352 VQIVYKPVDLSKVTSKCGSLGNIHHKPGGG 381
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 383-413 1.83e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.80  E-value: 1.83e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1958657810 383 VEVKSEKLDFKdRVQSKIGSLDNITHVPGGG 413
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 298-319 5.32e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 45.86  E-value: 5.32e-07
                          10        20
                  ....*....|....*....|..
gi 1958657810 298 DLKNVRSKIGSTENLKHQPGGG 319
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 321-350 5.36e-14

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.51  E-value: 5.36e-14
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958657810 321 VQIINKKLDLSNVQSKCGSKDNIKHVPGGG 350
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 37-300 3.94e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 65.73  E-value: 3.94e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810   37 PQPPADDGSEEPGSETSDAKSTPTAEAEEAGIGDTPNMEDQAAGHVTQARVAgvskdrtgndekkAKTSTPSCAKTPSNR 116
Cdd:PHA03247  2616 PLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA-------------RRLGRAAQASSPPQR 2682

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  117 PCLSPTRPTPGSSDPLIKPSSPAVCPEPAtsPKYVSSVTPRNGSPGTKQMKLKgADGKTGAKIATPRGAATPGqkGTSNA 196
Cdd:PHA03247  2683 PRRRAARPTVGSLTSLADPPPPPPTPEPA--PHALVSATPLPPGPAAARQASP-ALPAAPAPPAVPAGPATPG--GPARP 2757

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  197 TRIPAKTTPSPKTPPGSASKQPQRKLPP------AGAKTERGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTPPTREPk 270
Cdd:PHA03247  2758 ARPPTTAGPPAPAPPAAPAAGPPRRLTRpavaslSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP- 2836

                          250       260       270
                   ....*....|....*....|....*....|
gi 1958657810  271 kvaVVRTPPKSPSASKSRLQTAPVPMPDLK 300
Cdd:PHA03247  2837 ---TAPPPPPGPPPPSLPLGGSVAPGGDVR 2863
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 352-381 2.59e-10

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 55.11  E-value: 2.59e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958657810 352 VQIVYKPVDLSKVTSKCGSLGNIHHKPGGG 381
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 383-413 1.83e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.80  E-value: 1.83e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1958657810 383 VEVKSEKLDFKdRVQSKIGSLDNITHVPGGG 413
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 298-319 5.32e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 45.86  E-value: 5.32e-07
                          10        20
                  ....*....|....*....|..
gi 1958657810 298 DLKNVRSKIGSTENLKHQPGGG 319
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 52-297 1.24e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 47.65  E-value: 1.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  52 TSDAKSTPTAEAEEAGIGDTPnmedQAAGHVTQARVAGVSKDRTGNDEKKAKTSTPSCAKTP-----SNRPCLSPTRPTP 126
Cdd:pfam17823 138 PSEAFSAPRAAACRANASAAP----RAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPttaasSAPATLTPARGIS 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 127 GSSDPLIKPSSpavcpepATSPKYVSSVTPrngSPGTKQMKLKGADGKTGAKIATPRGAATPGQKGTSNATRIPAKTTPS 206
Cdd:pfam17823 214 TAATATGHPAA-------GTALAAVGNSSP---AAGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPA 283

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 207 PKTPPGSASKQPqrkLPPAGAKTERGEPPKSGERSGYSSPGSPgTPGSRSRTPSLPTPPTREPKKVAVVRTP---PKSPS 283
Cdd:pfam17823 284 KHMPSDTMARNP---AAPMGAQAQGPIIQVSTDQPVHNTAGEP-TPSPSNTTLEPNTPKSVASTNLAVVTTTkaqAKEPS 359

                         250
                  ....*....|....
gi 1958657810 284 ASksrlqtaPVPMP 297
Cdd:pfam17823 360 AS-------PVPVL 366
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 321-350 5.36e-14

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.51  E-value: 5.36e-14
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958657810 321 VQIINKKLDLSNVQSKCGSKDNIKHVPGGG 350
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 37-300 3.94e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 65.73  E-value: 3.94e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810   37 PQPPADDGSEEPGSETSDAKSTPTAEAEEAGIGDTPNMEDQAAGHVTQARVAgvskdrtgndekkAKTSTPSCAKTPSNR 116
Cdd:PHA03247  2616 PLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA-------------RRLGRAAQASSPPQR 2682

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  117 PCLSPTRPTPGSSDPLIKPSSPAVCPEPAtsPKYVSSVTPRNGSPGTKQMKLKgADGKTGAKIATPRGAATPGqkGTSNA 196
Cdd:PHA03247  2683 PRRRAARPTVGSLTSLADPPPPPPTPEPA--PHALVSATPLPPGPAAARQASP-ALPAAPAPPAVPAGPATPG--GPARP 2757

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  197 TRIPAKTTPSPKTPPGSASKQPQRKLPP------AGAKTERGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTPPTREPk 270
Cdd:PHA03247  2758 ARPPTTAGPPAPAPPAAPAAGPPRRLTRpavaslSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP- 2836

                          250       260       270
                   ....*....|....*....|....*....|
gi 1958657810  271 kvaVVRTPPKSPSASKSRLQTAPVPMPDLK 300
Cdd:PHA03247  2837 ---TAPPPPPGPPPPSLPLGGSVAPGGDVR 2863
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 352-381 2.59e-10

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 55.11  E-value: 2.59e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958657810 352 VQIVYKPVDLSKVTSKCGSLGNIHHKPGGG 381
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 383-413 1.83e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.80  E-value: 1.83e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1958657810 383 VEVKSEKLDFKdRVQSKIGSLDNITHVPGGG 413
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 34-317 3.15e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 56.33  E-value: 3.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810   34 ESPPQPPADDGSEEPGSETSDAKSTPTAEAEEAgigDTPNMEDQAAGHVTQARVAGVSKDRTGndekKAKTSTPSCAKTP 113
Cdd:PHA03307   121 PPPASPPPSPAPDLSEMLRPVGSPGPPPAASPP---AAGASPAAVASDAASSRQAALPLSSPE----ETARAPSSPPAEP 193

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  114 SNRPCLSPTRPTPGSSDPLIKPSSPAVCPEPATSPKYVSSVTPRNGSPGTKQMKLKGADGKTGAKIATPRGAATPGQKGT 193
Cdd:PHA03307   194 PPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEAS 273

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  194 SNATRIPAKTTPSPKTPPGSASKQPQRKLPPAGAKTERgePPKSGERSGY----------SSPGSPGTPGSRSRTPSLPT 263
Cdd:PHA03307   274 GWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSS--PRASSSSSSSressssstssSSESSRGAAVSPGPSPSRSP 351

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958657810  264 PPTREPKKVAVVRTPPKSPSASKSRLQTAPVPMPDLKNVRSKIGSTENLKHQPG 317
Cdd:PHA03307   352 SPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATG 405
PHA03247 PHA03247
large tegument protein UL36; Provisional
 36-308 9.25e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 9.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810   36 PPQPPADDGSEEPGSETSDAKSTPTAEAEEAGIGDTPNMEDQAAGHVTQARVAGVSKDRTGNDEKKAKTSTPSCAKTPSN 115
Cdd:PHA03247  2722 PPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSP 2801

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  116 RPCLSPTRPTPGSSDPLIKPSSPAVCPEPATSPKYVSSVTPRNGSPGTKQMKLKGADGKTGAKIATPRG-AATPGQKGTS 194
Cdd:PHA03247  2802 WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSpAAKPAAPARP 2881

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  195 NATRIP-----------AKTTPSPKTPPGSASKQPQRKLPPAGAKTERGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPT 263
Cdd:PHA03247  2882 PVRRLArpavsrstesfALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQ 2961

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1958657810  264 PPTRE--PKKVAVVRTppKSPSASKSRLQTAPVPMPDLKNVRSKIGS 308
Cdd:PHA03247  2962 PWLGAlvPGRVAVPRF--RVPQPAPSREAPASSTPPLTGHSLSRVSS 3006
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 298-319 5.32e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 45.86  E-value: 5.32e-07
                          10        20
                  ....*....|....*....|..
gi 1958657810 298 DLKNVRSKIGSTENLKHQPGGG 319
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1-288 3.87e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.78  E-value: 3.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810    1 MAEPRQEFDTMEdQAGDYTMLQDQEGDMDHGLKESPPQPPADDGSEEPGSETSDAKSTPTAEAEEAGIGDTPnmedqAAG 80
Cdd:PHA03307    60 AACDRFEPPTGP-PPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSP-----APD 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810   81 HVTQARVAGVSKDRTGNDEKKAKTSTPSCAKTPSNRPCLSPTRPTPGSSDPliKPSSPAVCPEPATSPKYVSSVTPRNGS 160
Cdd:PHA03307   134 LSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETAR--APSSPPAEPPPSTPPAAASPRPPRRSS 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  161 P-GTKQMKLKGADGKTGA--KIATPRGAATPGQKGTSNAtriPAKTTPSPKTPPGSASKQPQRKLPPAGAKTERGEPPKS 237
Cdd:PHA03307   212 PiSASASSPAPAPGRSAAddAGASSSDSSSSESSGCGWG---PENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSS 288

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958657810  238 G---ERSGYSSPGSPGTPGSRSRTPSL-------------PTPPTREPKKVAVVRTPPKSPSASKSR 288
Cdd:PHA03307   289 SsprERSPSPSPSSPGSGPAPSSPRASssssssresssssTSSSSESSRGAAVSPGPSPSRSPSPSR 355
PHA03378 PHA03378
EBNA-3B; Provisional
 104-297 4.82e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 49.30  E-value: 4.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 104 TSTPSCAKTPSNRPCLSPTRPTPGSSDPLIKPS---SPAVCPEPATSPKYVSSVTPRNGSPgtkqmklkgadgkTGAKIA 180
Cdd:PHA03378  618 TSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTphqPPQVEITPYKPTWTQIGHIPYQPSP-------------TGANTM 684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 181 TPRGAAtPGQKGTSNATRIPAKTTPSPKTPPGSASKQPQRKLPPAGAKTeRGEPPKSGERSGYSSPGSPGTPGSRSRTPS 260
Cdd:PHA03378  685 LPIQWA-PGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPG-RARPPAAAPGRARPPAAAPGRARPPAAAPG 762

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1958657810 261 LPTPPTREPKKvAVVRTPPKSPSASKSRLQTAPVPMP 297
Cdd:PHA03378  763 RARPPAAAPGA-PTPQPPPQAPPAPQQRPRGAPTPQP 798
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 52-297 1.24e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 47.65  E-value: 1.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  52 TSDAKSTPTAEAEEAGIGDTPnmedQAAGHVTQARVAGVSKDRTGNDEKKAKTSTPSCAKTP-----SNRPCLSPTRPTP 126
Cdd:pfam17823 138 PSEAFSAPRAAACRANASAAP----RAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPttaasSAPATLTPARGIS 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 127 GSSDPLIKPSSpavcpepATSPKYVSSVTPrngSPGTKQMKLKGADGKTGAKIATPRGAATPGQKGTSNATRIPAKTTPS 206
Cdd:pfam17823 214 TAATATGHPAA-------GTALAAVGNSSP---AAGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPA 283

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 207 PKTPPGSASKQPqrkLPPAGAKTERGEPPKSGERSGYSSPGSPgTPGSRSRTPSLPTPPTREPKKVAVVRTP---PKSPS 283
Cdd:pfam17823 284 KHMPSDTMARNP---AAPMGAQAQGPIIQVSTDQPVHNTAGEP-TPSPSNTTLEPNTPKSVASTNLAVVTTTkaqAKEPS 359

                         250
                  ....*....|....
gi 1958657810 284 ASksrlqtaPVPMP 297
Cdd:pfam17823 360 AS-------PVPVL 366
PHA03247 PHA03247
large tegument protein UL36; Provisional
 105-295 1.73e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 1.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  105 STPSCAKTPSNRPCLSPTRPTPGSSDPLIKPSSPavcPEPATSPKYVSSVTPRNGSPG----TKQMKLKGADGKTGAKIA 180
Cdd:PHA03247  2605 RGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP---DPHPPPTVPPPERPRDDPAPGrvsrPRRARRLGRAAQASSPPQ 2681

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  181 TPRGAATPGQKG--TSNATRIPAKTTPSPKTPPGSaskqPQRKLPPAGAKTERGEPPKSGERSGYSSPGSPGTPGSRSRT 258
Cdd:PHA03247  2682 RPRRRAARPTVGslTSLADPPPPPPTPEPAPHALV----SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARP 2757

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1958657810  259 PSLPTP-------PTREPKKVAVVRTPPKSPSASKSRLQTAPVP 295
Cdd:PHA03247  2758 ARPPTTagppapaPPAAPAAGPPRRLTRPAVASLSESRESLPSP 2801
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 35-298 2.25e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.09  E-value: 2.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810   35 SPPQPPADDGSEEPGSETSDAKSTPTAEAEEAGIGDTPNMEDQAAGhvTQARVAGVSKDRTGNDEKKAKTSTPSCAKTPS 114
Cdd:PHA03307   196 STPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSS--SESSGCGWGPENECPLPRPAPITLPTRIWEAS 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  115 nRPCLSPTRPTPGSSDPLIKPSSPAvcPEPATSPKYVSSVTPRNGSPGTKQMKlkGADGKTGAKIATPRGAATPGQKGTS 194
Cdd:PHA03307   274 -GWNGPSSRPGPASSSSSPRERSPS--PSPSSPGSGPAPSSPRASSSSSSSRE--SSSSSTSSSSESSRGAAVSPGPSPS 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  195 NAtripakttPSPKTPPGSASKQPQRKLPPAGAKTERGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTPPTRepkkvav 274
Cdd:PHA03307   349 RS--------PSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPR------- 413

                          250       260
                   ....*....|....*....|....
gi 1958657810  275 vRTPPKSPSASKSRLQTAPVPMPD 298
Cdd:PHA03307   414 -PSPLDAGAASGAFYARYPLLTPS 436
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
104-292 4.14e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.02  E-value: 4.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 104 TSTPSCAKTPSNRPCLSPTRPTPGSSDPLIKPSSPAVCPEPATSPKYVSSVtPRNGSPGTKQM---KLKGADGKTGAKIA 180
Cdd:PRK12323  372 AGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAA-PARRSPAPEALaaaRQASARGPGGAPAP 450

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 181 TPRGAATPGqKGTSNATRIPAKTTPSPKTPPGSASKQ-----------PQRKLPPAGAKTERGEP---PKSGERSGYSSP 246
Cdd:PRK12323  451 APAPAAAPA-AAARPAAAGPRPVAAAAAAAPARAAPAaapapadddppPWEELPPEFASPAPAQPdaaPAGWVAESIPDP 529

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1958657810 247 G-SPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSASKSRLQTA 292
Cdd:PRK12323  530 AtADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDM 576
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
37-299 4.35e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.00  E-value: 4.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  37 PQPPADDGSEEPGSETSDAKSTPTAEAEEAgigdTPNMEDQAAGHVTQARVAGVSKDRTGnDEKKAKTSTPSCAKTPSNR 116
Cdd:PRK07003  381 PAPGARAAAAVGASAVPAVTAVTGAAGAAL----APKAAAAAAATRAEAPPAAPAPPATA-DRGDDAADGDAPVPAKANA 455

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 117 PCLSPTRPTPGSSDPLIKPSsPAVCPEPATSPKYVSSVTPRngspgtkqmklkgADGKTGAKIATPRGAATPGQKGTSNA 196
Cdd:PRK07003  456 RASADSRCDERDAQPPADSG-SASAPASDAPPDAAFEPAPR-------------AAAPSAATPAAVPDARAPAAASREDA 521

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 197 TRIPAKTTPSPKTPPGSASKQPQRK---------LPPAGAK--TERGEPPKSGERSGYSSPGSPGTPGSRsrtPSLPTPP 265
Cdd:PRK07003  522 PAAAAPPAPEARPPTPAAAAPAARAggaaaaldvLRNAGMRvsSDRGARAAAAAKPAAAPAAAPKPAAPR---VAVQVPT 598

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1958657810 266 TREPKKVAVVRTPPKSPSASKSRLQTAPVPMPDL 299
Cdd:PRK07003  599 PRARAATGDAPPNGAARAEQAAESRGAPPPWEDI 632
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 55-293 1.09e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.16  E-value: 1.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810   55 AKSTPTAEAEEAGIGDTPNMEDQAAGHVTQARVAGVSKDRTGNDEKKAKTSTPSCAKTP----------------SNRPC 118
Cdd:PHA03307    24 PPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANesrstptwslstlapaSPARE 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  119 LSPTRPTPGSSDPLIKPSSPAVCPEPATSPKYVSSVTPRNGSPGTKQMKLKGADGKTgakiATPRGAATPGQkgTSNATR 198
Cdd:PHA03307   104 GSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPA----AVASDAASSRQ--AALPLS 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  199 IPAKTTPSPKTPPGSAskqPQRKLPPAGAKTERGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTP 278
Cdd:PHA03307   178 SPEETARAPSSPPAEP---PPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENE 254

                          250
                   ....*....|....*
gi 1958657810  279 PKSPSASKSRLQTAP 293
Cdd:PHA03307   255 CPLPRPAPITLPTRI 269
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
180-297 2.25e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 2.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 180 ATPRGAATPGQKGTSNATRIPAKTTPSPKTPPGSASKQPQRKLPPAGAKTERGEPPKSGERSGYSSPGSPGTPGSRSRTP 259
Cdd:PRK12323  372 AGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPA 451

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1958657810 260 SLP--TPPTREPKKVAVVRTPPKSPSASKSRLQTAPVPMP 297
Cdd:PRK12323  452 PAPaaAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAP 491
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 36-293 3.27e-04

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 43.34  E-value: 3.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810   36 PPQPPADDGSEEPGSETSDAKSTPTAEAE---------EAGIGDTPNMEDQAAGHVTQARVAGVSKDRTGNDEKKAKTST 106
Cdd:pfam15324  894 PQQAQADPDASVSESEPSEPSTSDIVEAAgggglqlfvDAGVPVDSEMIRHFVNEALAETIAIMLGDREAQREPPVAASV 973

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  107 PscAKTPSNRPCLSPTRPTPGSSDPLiKPSSPAVCPEPATSPKYVSSVTPRNGSPGTKQMKLKGADGK---------TGA 177
Cdd:pfam15324  974 P--GDLPTKETLLPTPVPTPQPTPPC-SPPSPLKEPSPVKTPDSSPCVSEHDFFPVKEIPPEKGADTGpavslvitpTVT 1050

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  178 KIATPRGAATPGQkgTSNATRIPAKTTPSPKTP-PGSASKQPQRKLPPAGAKTERGEP------PKSGERSGYSSPGSPG 250
Cdd:pfam15324 1051 PIATPPPAATPTP--PLSENSIDKLKSPSPELPkPWEDSDLPLEEENPNSEQEELHPRavvmsvARDEEPESVVLPASPP 1128

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1958657810  251 TPgsrsrTPSLPTPPTREPKkvavvrTPPKSPSASKSRLQTAP 293
Cdd:pfam15324 1129 EP-----KPLAPPPLGAAPP------SPPQSPSSSSSTLESSS 1160
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
37-225 4.41e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.94  E-value: 4.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  37 PQPPADDGSEEPGSETSDAKSTPTAEAEEAGigdTPNMEDQAAGHVTQARVAGvskdrtgndEKKAKTSTPSCAKTPSNR 116
Cdd:PRK12323  396 APAPAAPPAAPAAAPAAAAAARAVAAAPARR---SPAPEALAAARQASARGPG---------GAPAPAPAPAAAPAAAAR 463

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 117 PCLSPTRPTPGSSDPLIKPSSPAVCPEPATS--------PKYVSSVTPRNGSPGTKQMKLKGADGKTGAKIATPRGAATP 188
Cdd:PRK12323  464 PAAAGPRPVAAAAAAAPARAAPAAAPAPADDdpppweelPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAP 543

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1958657810 189 GqkgtSNATRIPAKTTPSPKTPPGSASKQPQRKLPPA 225
Cdd:PRK12323  544 A----PAAAPAPRAAAATEPVVAPRPPRASASGLPDM 576
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 51-294 7.78e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.37  E-value: 7.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  51 ETSDAKSTPTAEAEEAGIGDT-PNMEDQAAGHVTQARVAGVSKD--RTGNDEKKAKTSTPSCAK--TPSNRPCLSPTRPT 125
Cdd:PTZ00449  502 EDSDKHDEPPEGPEASGLPPKaPGDKEGEEGEHEDSKESDEPKEggKPGETKEGEVGKKPGPAKehKPSKIPTLSKKPEF 581

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 126 PGSSDPLIKPSSPAVCPEPATSPKYVSSVTPRngSPGTKQMKLKGADGKTGAKIATPRGAATPGQKGTSNATRIPaKTTP 205
Cdd:PTZ00449  582 PKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPK--LPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKII-KSPK 658

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 206 SPKTPPGSASKQPQRKL----PPAGAKTERGEPPKSGERSGYS--SPGSPGTPGSRSRTPSlPTPPTRePKKVAVVRTPP 279
Cdd:PTZ00449  659 PPKSPKPPFDPKFKEKFyddyLDAAAKSKETKTTVVLDESFESilKETLPETPGTPFTTPR-PLPPKL-PRDEEFPFEPI 736

                         250
                  ....*....|....*...
gi 1958657810 280 K---SPSASKSRLQTAPV 294
Cdd:PTZ00449  737 GdpdAEQPDDIEFFTPPE 754
PRK13863 PRK13863
T-DNA border endonuclease VirD2;
96-266 1.14e-03

T-DNA border endonuclease VirD2;


Pssm-ID: 237533 [Multi-domain]  Cd Length: 446  Bit Score: 41.47  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  96 GNDEKKAKTSTPSCAKTPSNRPcLSPTRPTPGSSDPLIKPSSPAVCPEPATSPKYVSSVTPRNGSPGTKQMKLKGADGKT 175
Cdd:PRK13863  223 EDHREPSQSFDTSPGEAPQGEP-ESAERPEKLQNESEVRLQEPAGSSIKADARIRVSLESERRAQPSASKIPVADDFGIE 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 176 GAKIATPRGAATPGQKGTSNATRIPAKTTPSpktppgsaSKQPQRKLP------PAGAKTERGEPPKSGERSGYSSPGSP 249
Cdd:PRK13863  302 TSYVAEGDVRKLEGNSGTPRLATEVATHTTS--------ERQQRRKRPrddegePSGAKRTRLNGIAVGPEANAGEQDGR 373

                         170
                  ....*....|....*..
gi 1958657810 250 GTPGSRSRTPSLPTPPT 266
Cdd:PRK13863  374 DDPITSPAQPPRSNPLA 390
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 48-350 1.89e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.06  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  48 PGSETSDAKSTPTAEAEEAgIGDTPNMEDQAAGHVTQARvagvSKDRTGNDEKKAKTSTPSCAKTPSNRPCLSPT----R 123
Cdd:pfam05109 455 PTNLTAPASTGPTVSTADV-TSPTPAGTTSGASPVTPSP----SPRDNGTESKAPDMTSPTSAVTTPTPNATSPTpavtT 529

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 124 PTPGSSDPLI---KPSSPAVCPEP-ATSPK-YVSSVTPRNGSPGTKQMKLKGADGKTGAKIATPRGAATPGQKGTSNATR 198
Cdd:pfam05109 530 PTPNATSPTLgktSPTSAVTTPTPnATSPTpAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTL 609

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 199 IPAKTTPSPKTPPGSASK---QPQRKLPPAGAKTERGEPpksgerSGYSSPGSPGTpgSRSRTPSLPTPPTREPKKVAVV 275
Cdd:pfam05109 610 GGTSSTPVVTSPPKNATSavtTGQHNITSSSTSSMSLRP------SSISETLSPST--SDNSTSHMPLLTSAHPTGGENI 681

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958657810 276 RTPPKSPSASKSRLQTAPVPMPDLKNVRSKIGSTENlKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGG 350
Cdd:pfam05109 682 TQVTPASTSTHHVSTSSPAPRPGTTSQASGPGNSST-STKPGEVNVTKGTPPKNATSPQAPSGQKTAVPTVTSTG 755
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 96-320 1.91e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.92  E-value: 1.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810   96 GNDEKKAKTSTPSCAKTPSNRPClSPTRPTPGSSdPLIKPSSPAVCPEPATSPKYVSSVtPRNGSPGTkqmklkgadgkt 175
Cdd:PHA03307    44 VSDSAELAAVTVVAGAAACDRFE-PPTGPPPGPG-TEAPANESRSTPTWSLSTLAPASP-AREGSPTP------------ 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  176 gakiatprgaatPGQKGTSNATRIPAKTTPSPKTPPGSASKQPQRKLPPAGAKTERGEPPKSGERSGySSPGSPGTPGSR 255
Cdd:PHA03307   109 ------------PGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA-SDAASSRQAALP 175

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958657810  256 SRTPSLPTPPTREPKKVAVVRTPPKSPSASKSRL-------QTAPVPMPDLKNVRSKIGSTENLKHQPGGGK 320
Cdd:PHA03307   176 LSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRsspisasASSPAPAPGRSAADDAGASSSDSSSSESSGC 247
PHA03247 PHA03247
large tegument protein UL36; Provisional
 105-316 2.82e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 2.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  105 STPSCAKTPSNRPCLSPTRP-TPGSSDPLIKPSSP---AVCPEPATSPKYVSSVTPRNGSPGTKQMKLKGADGKTGAKIA 180
Cdd:PHA03247  2490 FAAGAAPDPGGGGPPDPDAPpAPSRLAPAILPDEPvgePVHPRMLTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVP 2569

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  181 TPRGAATP-GQKGTSNATRIPAKTTPSPKTPPGSASKQPQRKLPPAGA--KTERGEPPKSGERSGYSSPGSPGTpgsrsr 257
Cdd:PHA03247  2570 PPRPAPRPsEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLppDTHAPDPPPPSPSPAANEPDPHPP------ 2643

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958657810  258 TPSLPTPPTREPKKVAVVRTPPKSPSASKSRLQTAPVPMPDLKNVRSKIGSTENLKHQP 316
Cdd:PHA03247  2644 PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPP 2702
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
78-267 6.41e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.06  E-value: 6.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  78 AAGHVTQARVAGVSKDRTGndekKAKTSTPSCAKTPSNRPCLSPTRPTPGSSDPLIKPSSPAVCPEPATSPKYVSSVTPR 157
Cdd:PRK07003  370 GGVPARVAGAVPAPGARAA----AAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADG 445

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 158 NGSPGTKQMKLKGADGKTGAKIATPRGAATPgQKGTSNATRIPAKTTPSPKTPPGSASKQPQRKLPPAGAKTERGEPPks 237
Cdd:PRK07003  446 DAPVPAKANARASADSRCDERDAQPPADSGS-ASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAP-- 522

                         170       180       190
                  ....*....|....*....|....*....|
gi 1958657810 238 gersgysSPGSPGTPGSRSRTPSLPTPPTR 267
Cdd:PRK07003  523 -------AAAAPPAPEARPPTPAAAAPAAR 545
PHA03309 PHA03309
transcriptional regulator ICP4; Provisional
 91-295 6.95e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 39.07  E-value: 6.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810   91 SKDRTGNDEKKAKTSTPSCAKTPSNRPCLSPTRPTP------GSSDPLIKPSSPAVCPEPATSPKyvSSVTPRNGSPGTK 164
Cdd:PHA03309  1819 SSSSSSSSSSSSPSSRPSRSATPSLSPSPSPPRRAPvdrsrsGRRRERDRPSANPFRWAPRQRSR--ADHSPDGTAPGDA 1896

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  165 QMKLKGADGKtGAKIATPrgaatpgqkgtSNATRIPAKTTPSPKTPPG-SASKQPQRKLPPAGAKTERGEPPKSGERSGY 243
Cdd:PHA03309  1897 PLNLEDGPGR-GRPIWTP-----------SSATTLPSRSGPEDSVDETeTEDSAPPARLAPSPLETSRAEDSEDSEYPEY 1964

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958657810  244 SSPG-SPGTPGSRSRTPSLPTppTREPKKVAVVRTPPKSPSASKSRLQTAPVP 295
Cdd:PHA03309  1965 SNPRlGKSPPALKSREARRPS--SKQPRRPSSGKNGHTDVSAASAFFLGRPAP 2015
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 181-312 7.24e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 39.02  E-value: 7.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 181 TPRGAATPGQkgTSNATRIPAKTTPSPKTPPGSASKQPQrklPPAGAKTERGEPPKSgersgysspgspgtpgsrsrTPS 260
Cdd:PRK14950  361 VPVPAPQPAK--PTAAAPSPVRPTPAPSTRPKAAAAANI---PPKEPVRETATPPPV--------------------PPR 415

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958657810 261 LPTPPTREPKKVAVVRTPPKSPSASKSrlqTAPVPMPDLKNVRSKIGSTENL 312
Cdd:PRK14950  416 PVAPPVPHTPESAPKLTRAAIPVDEKP---KYTPPAPPKEEEKALIADGDVL 464
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 176-295 8.12e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 38.90  E-value: 8.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 176 GAKIATPRGaatPGQKGTSNATRIPAKTTPSPK--------------TPPGSASKQPQRKLPPAGAKTERGEPPKSGERS 241
Cdd:PTZ00449  515 EASGLPPKA---PGDKEGEEGEHEDSKESDEPKeggkpgetkegevgKKPGPAKEHKPSKIPTLSKKPEFPKDPKHPKDP 591

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958657810 242 gySSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSASKSrlqtaPVP 295
Cdd:PTZ00449  592 --EEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKR-----PPP 638
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 93-285 8.36e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 38.74  E-value: 8.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810  93 DRTGNDEKKAKTSTPSCAKTPSNRPCLSPTRPTPGSSDplikpsspAVCPEPATSPKYVSSVTPrngSPGTKQmklKGAD 172
Cdd:pfam05109 435 NTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTAD--------VTSPTPAGTTSGASPVTP---SPSPRD---NGTE 500

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657810 173 GKTGAKIATPRGAATPGQKGTSNAtriPAKTTPSP--------KTPPGSASKQP----QRKLPPAGAKTERGEPPKSGER 240
Cdd:pfam05109 501 SKAPDMTSPTSAVTTPTPNATSPT---PAVTTPTPnatsptlgKTSPTSAVTTPtpnaTSPTPAVTTPTPNATIPTLGKT 577

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958657810 241 SGYSSPGSPgTPGSRSRTPSLPTPPTREPK-------KVAVVRTPPKSPSAS 285
Cdd:pfam05109 578 SPTSAVTTP-TPNATSPTVGETSPQANTTNhtlggtsSTPVVTSPPKNATSA 628
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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