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Conserved domains on  [gi|1958656913|ref|XP_038941300|]
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tetratricopeptide repeat protein 1 isoform X1 [Rattus norvegicus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11469168)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  30708253|10517866
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
119-221 6.50e-16

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 74.18  E-value: 6.50e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 119 LKEEGNEQFKRGDYVEAESSYSQALQMCPacfqkDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAEL 198
Cdd:COG4785    76 YYERGVAYDSLGDYDLAIADFDQALELDP-----DLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIA 150

                          90       100
                  ....*....|....*....|...
gi 1958656913 199 YEKTDKLDEALEDYKSILETDPS 221
Cdd:COG4785   151 LYYLGRYELAIADLEKALELDPN 173
 
Name Accession Description Interval E-value
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
119-221 6.50e-16

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 74.18  E-value: 6.50e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 119 LKEEGNEQFKRGDYVEAESSYSQALQMCPacfqkDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAEL 198
Cdd:COG4785    76 YYERGVAYDSLGDYDLAIADFDQALELDP-----DLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIA 150

                          90       100
                  ....*....|....*....|...
gi 1958656913 199 YEKTDKLDEALEDYKSILETDPS 221
Cdd:COG4785   151 LYYLGRYELAIADLEKALELDPN 173
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 116-212 1.18e-10

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 61.15  E-value: 1.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 116 SAKLKEEGNEQFKRGDYVEAESSYSQALQMcpacfqKDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRR 195
Cdd:TIGR00990 127 AAKLKEKGNKAYRNKDFNKAIKLYSKAIEC------KPDPVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNRR 200

                          90
                  ....*....|....*..
gi 1958656913 196 AELYEKTDKLDEALEDY 212
Cdd:TIGR00990 201 ANAYDGLGKYADALLDL 217
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 117-196 6.50e-06

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 46.70  E-value: 6.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 117 AKLKEEGNEQFKRGDYVEAESSYSQALQMCPACfqkdrSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRA 196
Cdd:PLN03088    3 KDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNN-----AELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKG 77
TPR_1 pfam00515
Tetratricopeptide repeat;
158-188 1.79e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 37.79  E-value: 1.79e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1958656913 158 FSNRAAARMKQDKKEMAITDCSKAIQLNPTY 188
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 158-188 9.98e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.89  E-value: 9.98e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958656913  158 FSNRAAARMKQDKKEMAITDCSKAIQLNPTY 188
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Name Accession Description Interval E-value
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
119-221 6.50e-16

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 74.18  E-value: 6.50e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 119 LKEEGNEQFKRGDYVEAESSYSQALQMCPacfqkDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAEL 198
Cdd:COG4785    76 YYERGVAYDSLGDYDLAIADFDQALELDP-----DLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIA 150

                          90       100
                  ....*....|....*....|...
gi 1958656913 199 YEKTDKLDEALEDYKSILETDPS 221
Cdd:COG4785   151 LYYLGRYELAIADLEKALELDPN 173
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
123-226 4.85e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 72.35  E-value: 4.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 123 GNEQFKRGDYVEAESSYSQALQMCPacfqkDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKT 202
Cdd:COG0457    15 GLAYRRLGRYEEAIEDYEKALELDP-----DDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQAL 89

                          90       100
                  ....*....|....*....|....
gi 1958656913 203 DKLDEALEDYKSILETDPSVHQAR 226
Cdd:COG0457    90 GRYEEALEDYDKALELDPDDAEAL 113
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
123-225 2.28e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.42  E-value: 2.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 123 GNEQFKRGDYVEAESSYSQALQMCPacfqkDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKT 202
Cdd:COG0457    49 GLAYLRLGRYEEALADYEQALELDP-----DDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLEL 123

                          90       100
                  ....*....|....*....|...
gi 1958656913 203 DKLDEALEDYKSILETDPSVHQA 225
Cdd:COG0457   124 GRYDEAIEAYERALELDPDDADA 146
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 123-226 5.74e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 68.10  E-value: 5.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 123 GNEQFKRGDYVEAESSYSQALQMCPACFQkdrsvLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKT 202
Cdd:COG3914   119 GNLLLALGRLEEALAALRRALALNPDFAE-----AYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDL 193

                          90       100
                  ....*....|....*....|....
gi 1958656913 203 DKLDEALEDYKSILETDPSVHQAR 226
Cdd:COG3914   194 GRLEEAIAAYRRALELDPDNADAH 217
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 117-226 8.81e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 67.71  E-value: 8.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 117 AKLKEEGNEQFKRGDYVEAESSYSQALQMCPACFQkdrsvLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRA 196
Cdd:COG3914    79 ALLELAALLLQALGRYEEALALYRRALALNPDNAE-----ALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLG 153

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958656913 197 ELYEKTDKLDEALEDYKSILETDPSVHQAR 226
Cdd:COG3914   154 EALRRLGRLEEAIAALRRALELDPDNAEAL 183
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 127-220 1.22e-12

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 63.83  E-value: 1.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 127 FKRGDYVEAESSYSQALQMCPacfqkDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKTDKLD 206
Cdd:COG5010    65 NKLGDFEESLALLEQALQLDP-----NNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDD 139

                          90
                  ....*....|....
gi 1958656913 207 EALEDYKSILETDP 220
Cdd:COG5010   140 EAKAALQRALGTSP 153
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
126-224 8.55e-12

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 59.80  E-value: 8.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 126 QFKRGDYVEAESSYSQALQMCPacfqkDRSVLFSNRAAARMKQDKKEMAItDCSKAIQLNPTYIRAILRRAELYEKTDKL 205
Cdd:COG3063     2 YLKLGDLEEAEEYYEKALELDP-----DNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDY 75

                          90
                  ....*....|....*....
gi 1958656913 206 DEALEDYKSILETDPSVHQ 224
Cdd:COG3063    76 DEALAYLERALELDPSALR 94
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 123-224 2.47e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.05  E-value: 2.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 123 GNEQFKRGDYVEAESSYSQALQMCPACFqkdRSVLfsNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKT 202
Cdd:COG2956   151 AELYLEQGDYDEAIEALEKALKLDPDCA---RALL--LLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKL 225

                          90       100
                  ....*....|....*....|..
gi 1958656913 203 DKLDEALEDYKSILETDPSVHQ 224
Cdd:COG2956   226 GDPEEALELLRKALELDPSDDL 247
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 116-212 1.18e-10

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 61.15  E-value: 1.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 116 SAKLKEEGNEQFKRGDYVEAESSYSQALQMcpacfqKDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRR 195
Cdd:TIGR00990 127 AAKLKEKGNKAYRNKDFNKAIKLYSKAIEC------KPDPVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNRR 200

                          90
                  ....*....|....*..
gi 1958656913 196 AELYEKTDKLDEALEDY 212
Cdd:TIGR00990 201 ANAYDGLGKYADALLDL 217
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
123-217 3.47e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.48  E-value: 3.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 123 GNEQFKRGDYVEAESSYSQALQMCPacfqkDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKT 202
Cdd:COG0457    83 GLALQALGRYEEALEDYDKALELDP-----DDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157

                          90
                  ....*....|....*
gi 1958656913 203 DKLDEALEDYKSILE 217
Cdd:COG0457   158 GRYEEALELLEKLEA 172
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 123-220 3.76e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 56.55  E-value: 3.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 123 GNEQFKRGDYVEAESSYSQALQMCPacfqkDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKT 202
Cdd:COG4235    24 GRAYLRLGRYDEALAAYEKALRLDP-----DNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQ 98

                          90
                  ....*....|....*...
gi 1958656913 203 DKLDEALEDYKSILETDP 220
Cdd:COG4235    99 GDYAEAIAAWQKLLALLP 116
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 127-220 5.15e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 56.35  E-value: 5.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 127 FKRGDYVEAESSYSQALQMCPacfqkDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKTDKLD 206
Cdd:COG4783    49 LQLGDLDEAIVLLHEALELDP-----DEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPD 123

                          90
                  ....*....|....
gi 1958656913 207 EALEDYKSILETDP 220
Cdd:COG4783   124 EAIAALEKALELDP 137
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 127-227 5.46e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.20  E-value: 5.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 127 FKRGDYVEAESSYSQALQMCPacfqkDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKTDKLD 206
Cdd:COG2956   121 EQEGDWEKAIEVLERLLKLGP-----ENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYE 195

                          90       100
                  ....*....|....*....|.
gi 1958656913 207 EALEDYKSILETDPSVHQARE 227
Cdd:COG2956   196 EAIAALERALEQDPDYLPALP 216
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
116-221 1.18e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 56.85  E-value: 1.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 116 SAKLKEEGNEQFKRGDYVEAESSYSQALQMCPacfqkDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRR 195
Cdd:COG4785    39 IALADLALALAAAALAAAALAAERIDRALALP-----DLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNR 113

                          90       100
                  ....*....|....*....|....*.
gi 1958656913 196 AELYEKTDKLDEALEDYKSILETDPS 221
Cdd:COG4785   114 GLAYLLLGDYDAALEDFDRALELDPD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 121-220 1.51e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.81  E-value: 1.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 121 EEGNEQFKRGDYVEAESSYSQALQMCPacfqkDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYE 200
Cdd:COG4783     9 ALAQALLLAGDYDEAEALLEKALELDP-----DNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALL 83

                          90       100
                  ....*....|....*....|
gi 1958656913 201 KTDKLDEALEDYKSILETDP 220
Cdd:COG4783    84 KAGDYDEALALLEKALKLDP 103
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
160-225 4.23e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 55.40  E-value: 4.23e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958656913 160 NRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKTDKLDEALEDYKSILETDPSVHQA 225
Cdd:COG0457    13 NLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA 78
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 123-221 5.91e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 49.34  E-value: 5.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 123 GNEQFKRGDYVEAESSYSQALQMCPacfqkDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKT 202
Cdd:COG2956    83 AQDYLKAGLLDRAEELLEKLLELDP-----DDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQ 157

                          90
                  ....*....|....*....
gi 1958656913 203 DKLDEALEDYKSILETDPS 221
Cdd:COG2956   158 GDYDEAIEALEKALKLDPD 176
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 125-228 6.42e-07

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 46.91  E-value: 6.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 125 EQFKRGDYVEAESSYSQALQMCPACFQKDRsVLFsNRAAARMKQDKKEMAITDCSKAIQLNPTYIR---AILRRAELYEK 201
Cdd:COG1729     2 ALLKAGDYDEAIAAFKAFLKRYPNSPLAPD-ALY-WLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdALLKLGLSYLE 79

                          90       100
                  ....*....|....*....|....*..
gi 1958656913 202 TDKLDEALEDYKSILETDPSVHQAREA 228
Cdd:COG1729    80 LGDYDKARATLEELIKKYPDSEAAKEA 106
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 127-220 1.37e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.93  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 127 FKRGDYVEAESSYSQALQMCPACFqkdrSVLFsNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKTDKLD 206
Cdd:TIGR02917 476 LGKGDLAKAREAFEKALSIEPDFF----PAAA-NLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEE 550

                          90
                  ....*....|....
gi 1958656913 207 EALEDYKSILETDP 220
Cdd:TIGR02917 551 EAVAWLEKAAELNP 564
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 123-220 2.22e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.80  E-value: 2.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 123 GNEQFKRGDYVEAESSYSQALQMCPacfqkDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKT 202
Cdd:COG2956    49 GNLYRRRGEYDRAIRIHQKLLERDP-----DRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQE 123

                          90
                  ....*....|....*...
gi 1958656913 203 DKLDEALEDYKSILETDP 220
Cdd:COG2956   124 GDWEKAIEVLERLLKLGP 141
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 161-226 2.53e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.95  E-value: 2.53e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958656913 161 RAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKTDKLDEALEDYKSILETDPSVHQAR 226
Cdd:COG4783    10 LAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEAR 75
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 161-226 2.90e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 46.11  E-value: 2.90e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958656913 161 RAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKTDKLDEALEDYKSILETDPSVHQAR 226
Cdd:COG5010    60 SDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAY 125
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 121-228 2.96e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.42  E-value: 2.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 121 EEGNEQFKRGDYVEAESSYSQALQMCPacfqKDRSVLFsNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYE 200
Cdd:COG2956    13 FKGLNYLLNGQPDKAIDLLEEALELDP----ETVEAHL-ALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYL 87

                          90       100
                  ....*....|....*....|....*...
gi 1958656913 201 KTDKLDEALEDYKSILETDPSVHQAREA 228
Cdd:COG2956    88 KAGLLDRAEELLEKLLELDPDDAEALRL 115
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 162-226 6.10e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 44.61  E-value: 6.10e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958656913 162 AAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKTDKLDEALEDYKSILETDPSVHQAR 226
Cdd:COG4235    24 GRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEAL 88
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 117-196 6.50e-06

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 46.70  E-value: 6.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 117 AKLKEEGNEQFKRGDYVEAESSYSQALQMCPACfqkdrSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRA 196
Cdd:PLN03088    3 KDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNN-----AELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKG 77
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
123-221 3.26e-05

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 44.10  E-value: 3.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 123 GNEQFKRGDYVEAESSYSQALQmcpACFQKDRSVLFSnRAAARMKQDKKEMAITDCSKAIQLNPTY--IRAILRRAELYE 200
Cdd:COG4700    96 ADALLELGRYDEAIELYEEALT---GIFADDPHILLG-LAQALFELGRYAEALETLEKLIAKNPDFksSDAHLLYARALE 171

                          90       100
                  ....*....|....*....|.
gi 1958656913 201 KTDKLDEALEDYKSILETDPS 221
Cdd:COG4700   172 ALGDLEAAEAELEALARRYSG 192
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
164-226 6.71e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.92  E-value: 6.71e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958656913 164 ARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKTDKLDEALEdYKSILETDPSVHQAR 226
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEAL 62
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
123-214 1.35e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 41.82  E-value: 1.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 123 GNEQFKRGDYVEAESSYSQALQMCPacfQKDRSVLfsNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKT 202
Cdd:COG4785   114 GLAYLLLGDYDAALEDFDRALELDP---DYAYAYL--NRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAERKL 188

                          90
                  ....*....|..
gi 1958656913 203 DKlDEALEDYKS 214
Cdd:COG4785   189 DP-EKALALLLE 199
TPR_1 pfam00515
Tetratricopeptide repeat;
158-188 1.79e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 37.79  E-value: 1.79e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1958656913 158 FSNRAAARMKQDKKEMAITDCSKAIQLNPTY 188
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 126-219 3.03e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.25  E-value: 3.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 126 QFKRGDYVEAESSYSQALQMCPacfqkDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTyIRAILRRAELYEKTDKL 205
Cdd:COG2956   188 YLEQGDYEEAIAALERALEQDP-----DYLPALPRLAELYEKLGDPEEALELLRKALELDPS-DDLLLALADLLERKEGL 261

                          90
                  ....*....|....
gi 1958656913 206 DEALEDYKSILETD 219
Cdd:COG2956   262 EAALALLERQLRRH 275
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 123-220 5.09e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 5.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656913 123 GNEQFKRGDYVEAESSYSQALQmcpacfqKDRSVLFSNRAAARMK--QDKKEMAITDCSKAIQLNPTYIRAILRRAELYE 200
Cdd:TIGR02917 132 GLAYLGLGQLELAQKSYEQALA-------IDPRSLYAKLGLAQLAlaENRFDEARALIDEVLTADPGNVDALLLKGDLLL 204

                          90       100
                  ....*....|....*....|
gi 1958656913 201 KTDKLDEALEDYKSILETDP 220
Cdd:TIGR02917 205 SLGNIELALAAYRKAIALRP 224
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
182-225 8.22e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.60  E-value: 8.22e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958656913 182 IQLNPTYIRAILRRAELYEKTDKLDEALEDYKSILETDPSVHQA 225
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEA 44
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 158-188 9.98e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.89  E-value: 9.98e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958656913  158 FSNRAAARMKQDKKEMAITDCSKAIQLNPTY 188
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 162-220 1.45e-03

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 39.41  E-value: 1.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958656913 162 AAARMKQDKKEMAITDCSKAIQLNPTYIRAILRRAELYEKTDKLDEALEDYKSILETDP 220
Cdd:PRK11788  187 AQQALARGDLDAARALLKKALAADPQCVRASILLGDLALAQGDYAAAIEALERVEEQDP 245
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 123-186 4.55e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 36.86  E-value: 4.55e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958656913 123 GNEQFKRGDYVEAESSYSQALQMCPacfqkDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNP 186
Cdd:COG5010    95 ALLYSRSGDKDEAKEYYEKALALSP-----DNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
TPR_1 pfam00515
Tetratricopeptide repeat;
189-221 5.70e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 33.55  E-value: 5.70e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1958656913 189 IRAILRRAELYEKTDKLDEALEDYKSILETDPS 221
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPN 33
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 189-221 6.68e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 33.57  E-value: 6.68e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958656913  189 IRAILRRAELYEKTDKLDEALEDYKSILETDPS 221
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
TPR_17 pfam13431
Tetratricopeptide repeat;
178-210 8.40e-03

Tetratricopeptide repeat;


Pssm-ID: 433201 [Multi-domain]  Cd Length: 34  Bit Score: 33.29  E-value: 8.40e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1958656913 178 CSKAIQLNPTYIRAILRRAELYEKTDKLDEALE 210
Cdd:pfam13431   2 YLKALELDPNNADAYYNLAVLLLELGQSETALQ 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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