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Conserved domains on  [gi|1958656180|ref|XP_038941008|]
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phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X2 [Rattus norvegicus]

Protein Classification

phosphoribosyl pyrophosphate synthase-associated protein( domain architecture ID 11226557)

phosphoribosyl pyrophosphate synthase-associated protein seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 139-323 1.96e-112

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


:

Pssm-ID: 434046  Cd Length: 184  Bit Score: 323.69  E-value: 1.96e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 139 DYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVRSvAAIHPSLEIPMLIPKEKPPITVVG 218
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRS-RTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 219 DVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIPHEIQKLQCPKIKT 298
Cdd:pfam14572  80 DVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 1958656180 299 VDISMILSEAIRRIHNGESMSYLFR 323
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 20-98 4.49e-23

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


:

Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 92.10  E-value: 4.49e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  20 LVLFSANSNsscMELSKKIAE----------------------------------------DVNTTIMELLIMVYACKTS 59
Cdd:pfam13793   1 LKIFSGNSN---PELAEKIAKrlgiplgkatvsrfsdgeiyvrieesvrgkdvfiiqstcpPVNDNLMELLIMIDALKRA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1958656180  60 CAKSIIGVIPYFPYSKQCKM-RKRGSIVSKLLASMMCKAG 98
Cdd:pfam13793  78 SAKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
 
Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 139-323 1.96e-112

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 323.69  E-value: 1.96e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 139 DYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVRSvAAIHPSLEIPMLIPKEKPPITVVG 218
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRS-RTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 219 DVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIPHEIQKLQCPKIKT 298
Cdd:pfam14572  80 DVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 1958656180 299 VDISMILSEAIRRIHNGESMSYLFR 323
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 42-323 7.41e-78

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 240.35  E-value: 7.41e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:COG0462    63 VNDNLMELLIMIDALKRASARRITAVIPYYGYARQdRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPV 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 121 DNLRASPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPpmvRSVAAIH 198
Cdd:COG0462   143 DHLYAAPLLADYIKSK--DLEDLVVV--SPdvGGVKRARAFAKRLGAPLAIIDKR-----------RPGA---NEVEVMN 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 199 PSLEIpmlipKEKPPItVVGDV---GGriaiivddiiddvdSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAI 275
Cdd:COG0462   205 IIGDV-----EGKTCI-IVDDMidtGG--------------TLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSPI 264

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1958656180 276 DEVVVTNTIPHEIQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 323
Cdd:COG0462   265 DELVVTDTIPLPEEK-RCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 42-323 1.34e-71

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 224.47  E-value: 1.34e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRG-SIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:TIGR01251  61 VNDNLMELLIMIDALKRASAKSITAVIPYYGYARQDKKFKSRePISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPV 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 121 DNLRASPFLLQYIQEEIPDyrNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPPMVRSVAAIhps 200
Cdd:TIGR01251 141 DNLYASPVLAEYLKKKILD--NPVVVSPDAGGVERAKKVADALGCPLAIIDKR-----------RISATNEVEVMNL--- 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 201 leipmlipkekppitvVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVV 280
Cdd:TIGR01251 205 ----------------VGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEVIV 268

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1958656180 281 TNTIPHEIqklQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 323
Cdd:TIGR01251 269 TNTIPHEK---HKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
42-323 1.98e-71

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 223.84  E-value: 1.98e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:PRK01259   60 TNDNLMELLIMIDALKRASAGRITAVIPYFGYARQdRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPV 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 121 DNLRASPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSPPMVRSVaaih 198
Cdd:PRK01259  140 DNLYGSPILLEDIKQK--NLENLVVV--SPdvGGVVRARALAKRLDADLAII------------DKRRPRANVSEV---- 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 199 psleipmlipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEV 278
Cdd:PRK01259  200 ---------------MNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKSVYAYATHPVLSGGAIERIENSVIDEL 264

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1958656180 279 VVTNTIPHEIQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 323
Cdd:PRK01259  265 VVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLFD 309
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 20-98 4.49e-23

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 92.10  E-value: 4.49e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  20 LVLFSANSNsscMELSKKIAE----------------------------------------DVNTTIMELLIMVYACKTS 59
Cdd:pfam13793   1 LKIFSGNSN---PELAEKIAKrlgiplgkatvsrfsdgeiyvrieesvrgkdvfiiqstcpPVNDNLMELLIMIDALKRA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1958656180  60 CAKSIIGVIPYFPYSKQCKM-RKRGSIVSKLLASMMCKAG 98
Cdd:pfam13793  78 SAKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
 
Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 139-323 1.96e-112

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 323.69  E-value: 1.96e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 139 DYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVRSvAAIHPSLEIPMLIPKEKPPITVVG 218
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRS-RTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 219 DVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIPHEIQKLQCPKIKT 298
Cdd:pfam14572  80 DVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 1958656180 299 VDISMILSEAIRRIHNGESMSYLFR 323
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 42-323 7.41e-78

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 240.35  E-value: 7.41e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:COG0462    63 VNDNLMELLIMIDALKRASARRITAVIPYYGYARQdRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPV 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 121 DNLRASPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPpmvRSVAAIH 198
Cdd:COG0462   143 DHLYAAPLLADYIKSK--DLEDLVVV--SPdvGGVKRARAFAKRLGAPLAIIDKR-----------RPGA---NEVEVMN 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 199 PSLEIpmlipKEKPPItVVGDV---GGriaiivddiiddvdSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAI 275
Cdd:COG0462   205 IIGDV-----EGKTCI-IVDDMidtGG--------------TLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSPI 264

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1958656180 276 DEVVVTNTIPHEIQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 323
Cdd:COG0462   265 DELVVTDTIPLPEEK-RCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 42-323 1.34e-71

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 224.47  E-value: 1.34e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRG-SIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:TIGR01251  61 VNDNLMELLIMIDALKRASAKSITAVIPYYGYARQDKKFKSRePISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPV 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 121 DNLRASPFLLQYIQEEIPDyrNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPPMVRSVAAIhps 200
Cdd:TIGR01251 141 DNLYASPVLAEYLKKKILD--NPVVVSPDAGGVERAKKVADALGCPLAIIDKR-----------RISATNEVEVMNL--- 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 201 leipmlipkekppitvVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVV 280
Cdd:TIGR01251 205 ----------------VGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEVIV 268

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1958656180 281 TNTIPHEIqklQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 323
Cdd:TIGR01251 269 TNTIPHEK---HKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
42-323 1.98e-71

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 223.84  E-value: 1.98e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:PRK01259   60 TNDNLMELLIMIDALKRASAGRITAVIPYFGYARQdRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPV 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 121 DNLRASPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSPPMVRSVaaih 198
Cdd:PRK01259  140 DNLYGSPILLEDIKQK--NLENLVVV--SPdvGGVVRARALAKRLDADLAII------------DKRRPRANVSEV---- 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 199 psleipmlipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEV 278
Cdd:PRK01259  200 ---------------MNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKSVYAYATHPVLSGGAIERIENSVIDEL 264

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1958656180 279 VVTNTIPHEIQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 323
Cdd:PRK01259  265 VVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLFD 309
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
43-322 2.37e-52

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 175.12  E-value: 2.37e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  43 NTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRK-RGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:PRK04923   67 AENLMELLVLIDALKRASAASVTAVIPYFGYSRQdRRMRSsRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPV 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 121 DNLRASPFLLQYIQEEIpDYRNAVIVAKSPASAKRAQSFAERLrlgiavihgeaQDAESDLVDGRHSPPMVRSVaaihps 200
Cdd:PRK04923  147 DNVYASPLLLADIWRAY-GTDNLIVVSPDVGGVVRARAVAKRL-----------DDADLAIIDKRRPRANVATV------ 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 201 leipmlipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVV 280
Cdd:PRK04923  209 -------------MNIIGDVQGKTCVLVDDLVDTAGTLCAAAAALKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVV 275

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1958656180 281 TNTIPHEIQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLF 322
Cdd:PRK04923  276 TDTIPLSEAARACAKIRQLSVAELLAETIRRIAFGESVSSLY 317
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
38-322 4.63e-50

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 169.20  E-value: 4.63e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  38 IAEDVNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFF 116
Cdd:PRK02269   61 TSSPVNDNLMEILIMVDALKRASAESINVVMPYYGYARQdRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFF 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 117 NIPVDNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSppmvrsvaa 196
Cdd:PRK02269  141 DIPVDHLMGAPLIADYFDRRGLVGDDVVVVSPDHGGVTRARKLAQFLKTPIAII------------DKRRS--------- 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 197 ihpslEIPMLIPKekpPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAID 276
Cdd:PRK02269  200 -----VDKMNTSE---VMNIIGNVKGKKCILIDDMIDTAGTICHAADALAEAGATEVYASCTHPVLSGPALDNIQKSAIE 271

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1958656180 277 EVVVTNTIPHEIQKLqCPKIKTVDISMILSEAIRRIHNGESMSYLF 322
Cdd:PRK02269  272 KLVVLDTIYLPEERL-IDKIEQISIADLLGEAIIRIHEKRPLSPLF 316
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 42-323 1.03e-48

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 165.25  E-value: 1.03e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:PLN02369   51 ANENLMELLIMIDACRRASAKRITAVIPYFGYARAdRKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPV 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 121 DNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLrlgiavihgeaQDAESDLVDGRHSPpmvrsvaaiHPS 200
Cdd:PLN02369  131 DHVYGQPVILDYLASKTISSPDLVVVSPDVGGVARARAFAKKL-----------SDAPLAIVDKRRQG---------HNV 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 201 LEipmlipkekpPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVV 280
Cdd:PLN02369  191 AE----------VMNLIGDVKGKVAIMVDDMIDTAGTITKGAALLHQEGAREVYACATHAVFSPPAIERLSSGLFQEVIV 260

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1958656180 281 TNTIPHEIQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 323
Cdd:PLN02369  261 TNTIPVSEKN-YFPQLTVLSVANLLGETIWRVHDDCSVSSIFD 302
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
42-322 6.99e-48

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 162.81  E-value: 6.99e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:PRK03092   49 INKWLMEQLIMIDALKRASAKRITVVLPFYPYARQdKKHRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPV 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 121 DNLRASPFLLQYIQEEIPDyRNAVIVAKSPASAKRAQSFAERLrlgiavihGEAqdaesdlvdgrhspPMvrsvAAIHPS 200
Cdd:PRK03092  129 DHLFAMPLLADYVRDKYDL-DNVTVVSPDAGRVRVAEQWADRL--------GGA--------------PL----AFIHKT 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 201 LEIpmLIPKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVV 280
Cdd:PRK03092  182 RDP--TVPNQVVANRVVGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIAATHGVLSGPAAERLKNCGAREVVV 259

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1958656180 281 TNTIPHEIQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLF 322
Cdd:PRK03092  260 TDTLPIPEEK-RFDKLTVLSIAPLLARAIREVFEDGSVTSLF 300
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 42-323 1.77e-46

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 160.29  E-value: 1.77e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSK-QCKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:PRK02812   81 VNDHLMELLIMVDACRRASARQITAVIPYYGYARaDRKTAGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPC 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 121 DNLRASPFLLQYIQEEipDYRNAVIVAKSPASAKRAQSFAERLRlgiavihgeaqDAESDLVDGRHSPPMVRSVaaihps 200
Cdd:PRK02812  161 DHVYGSPVLLDYLASK--NLEDIVVVSPDVGGVARARAFAKKLN-----------DAPLAIIDKRRQAHNVAEV------ 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 201 leipmlipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVV 280
Cdd:PRK02812  222 -------------LNVIGDVKGKTAILVDDMIDTGGTICEGARLLRKEGAKQVYACATHAVFSPPAIERLSSGLFEEVIV 288

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1958656180 281 TNTIPHEiQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 323
Cdd:PRK02812  289 TNTIPVP-EERRFPQLKVLSVANMLGEAIWRIHEESSVSSMFR 330
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 42-323 1.52e-45

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 157.59  E-value: 1.52e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRK-RGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:PRK02458   69 VNDHLWELLIMIDACKRASANTVNVVLPYFGYARQDRIAKpREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPV 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 121 DNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDlvDGrhsppmvrsvaaihps 200
Cdd:PRK02458  149 DNLFTVPLFAKHYCKKGLSGSDVVVVSPKNSGIKRARSLAEYLDAPIAIIDYAQDDSERE--EG---------------- 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 201 leipmlipkekppiTVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVV 280
Cdd:PRK02458  211 --------------YIIGDVAGKKAILIDDILNTGKTFAEAAKIVEREGATEIYAVASHGLFAGGAAEVLENAPIKEILV 276

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1958656180 281 TNTIpheIQKLQCPK-IKTVDISMILSEAIRRIHNGESMSYLFR 323
Cdd:PRK02458  277 TDSV---ATKERVPKnVTYLSASELIADAIIRIHERKPLSPLFA 317
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 42-322 1.48e-43

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 155.03  E-value: 1.48e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFN--I 118
Cdd:PTZ00145  179 VNENLIELLLMISTCRRASAKKITAVIPYYGYARQdRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFGprV 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 119 PVDNLRASPFLLQYIQEEipDYRNAVIVAKSPASAKRAQSFAERLrlgiavIHGEAQDAEsdlvdgrhsppmvrsvaaih 198
Cdd:PTZ00145  259 PVDNLEAQLIGLDYFTKK--DLYKPVIVSPDAGGVYRARKFQDGL------NHRGISDCG-------------------- 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 199 psleIPMLI-----PKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEES 273
Cdd:PTZ00145  311 ----IAMLIkqrtkPNEIEKMDLVGNVYDSDVIIVDDMIDTSGTLCEAAKQLKKHGARRVFAFATHGLFSGPAIERIEAS 386

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958656180 274 AIDEVVVTNTIPHEIQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLF 322
Cdd:PTZ00145  387 PLEEVVVTDTVKSNKNIDSCKKITKLSVSVLVADAIRRIHQKESLNDLF 435
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 42-322 8.41e-42

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 147.76  E-value: 8.41e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:PRK00553   69 VNDSLMELLIAIDALKRGSAKSITAILPYYGYARQdRKTAGREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPV 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 121 DNLRASPFLLQYIQEEIpDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSPPMVRSvaaihps 200
Cdd:PRK00553  149 DILRTYHVFLSRVLELL-GKKDLVVVSPDYGGVKRARLIAESLELPLAII------------DKRRPKHNVAE------- 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 201 leipmlipkekpPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEES----AID 276
Cdd:PRK00553  209 ------------SINVLGEVKNKNCLIVDDMIDTGGTVIAAAKLLKKQKAKKVCVMATHGLFNKNAIQLFDEAfkkkLID 276

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1958656180 277 EVVVTNTIPHEIQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLF 322
Cdd:PRK00553  277 KLFVSNSIPQTKFE-KKPQFKVVDLAHLYEEVLLCYANGGSISAIY 321
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 43-291 2.11e-25

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 103.07  E-value: 2.11e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  43 NTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRG-SIVSKLLASMMcKAGLTHLITMDLHQKEIQGFFNIPVD 121
Cdd:PRK00934   59 DENLVELLLLIDALRDEGAKSITLVIPYLGYARQDKRFKPGePISARAIAKII-SAYYDRIITINIHEPSILEFFPIPFI 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 122 NLRASPFLLQYIQEeipDYRNAVIVAKSPASAKRAQSFAERLrlGIAVIHGEAQdaesdlvdgRHSPPMVRsvaaIHPSl 201
Cdd:PRK00934  138 NLDAAPLIAEYIGD---KLDDPLVLAPDKGALELAKEAAEIL--GCEYDYLEKT---------RISPTEVE----IAPK- 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 202 EIpmlipkekppitvvgDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVT 281
Cdd:PRK00934  199 NL---------------DVKGKDVLIVDDIISTGGTMATAIKILKEQGAKKVYVACVHPVLVGDAILKLYNAGVDEIIVT 263

                         250
                  ....*....|
gi 1958656180 282 NTIPHEIQKL 291
Cdd:PRK00934  264 DTLESEVSKI 273
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 20-98 4.49e-23

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 92.10  E-value: 4.49e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  20 LVLFSANSNsscMELSKKIAE----------------------------------------DVNTTIMELLIMVYACKTS 59
Cdd:pfam13793   1 LKIFSGNSN---PELAEKIAKrlgiplgkatvsrfsdgeiyvrieesvrgkdvfiiqstcpPVNDNLMELLIMIDALKRA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1958656180  60 CAKSIIGVIPYFPYSKQCKM-RKRGSIVSKLLASMMCKAG 98
Cdd:pfam13793  78 SAKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 42-324 2.16e-18

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 85.00  E-value: 2.16e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  42 VNTTIMELLIMVYACKTScAKSIIGVIPYFPYSKQCKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIP-V 120
Cdd:PRK06827  104 PDDHFQDLKRTIDAIRGK-ARRITVIMPFLYESRQHKRKGRESLDCALALQELEELGVDNIITFDAHDPRIENAIPLMgF 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 121 DNLRASPFLLQYIQEEIPDYR----NAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaQDaESDLVDGRHsppmvrsvaa 196
Cdd:PRK06827  183 ENLYPSYQIIKALLKNEKDLEidkdHLMVISPDTGAMDRAKYYASVLGVDLGLFYKR-RD-YSRVVNGRN---------- 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 197 ihpsleipmlipkekpPITVV----GDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLsSDAPRLI-- 270
Cdd:PRK06827  251 ----------------PIVAHeflgRDVEGKDVLIVDDMIASGGSMIDAAKELKSRGAKKIIVAATFGFF-TNGLEKFdk 313

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958656180 271 --EESAIDEVVVTNTIPHEIQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFRN 324
Cdd:PRK06827  314 ayEEGYFDRIIGTNLVYHPEELLSKPWYIEVDMSKLIARIIDALNHDVSLSKLLDP 369
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
43-311 3.72e-10

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 59.95  E-value: 3.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180  43 NTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRGSIVS-----KLLAsmmckAGLTHLITMD--LHQ-KEIQG 114
Cdd:PRK07199   62 DEKLLPLLFAAEAARELGARRVGLVAPYLAYMRQDIAFHPGEAISqrhfaRLLS-----GSFDRLVTVDphLHRyPSLSE 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 115 FFNIPVDNLRASPFLLQYIQEEIPDyrnAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPpmvRSV 194
Cdd:PRK07199  137 VYPIPAVVLSAAPAIAAWIRAHVPR---PLLIGPDEESEQWVAAVAERAGAPHAVLRKT-----------RHGD---RDV 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656180 195 AaihpsLEIPMLIPKEKPPITVVGDV--GGRiaiivddiiddvdSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEE 272
Cdd:PRK07199  200 E-----ISLPDAAPWAGRTPVLVDDIvsTGR-------------TLIEAARQLRAAGAASPDCVVVHALFAGDAYSALAA 261

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1958656180 273 SAIDEVVVTNTIPHEIQklqcpkikTVDISMILSEAIRR 311
Cdd:PRK07199  262 AGIARVVSTDTVPHPSN--------AISLAPLLAEALRR 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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