secreted phosphoprotein 24 isoform X1 [Rattus norvegicus]
Protein Classification
C1 family peptidase; cystatin family protein( domain architecture ID 10289479)
C1 family peptidase (also called papain family protein) is a papain-like cysteine peptidase that catalyzes the hydrolysis of peptide bonds in substrates using a catalytic dyad of Cys and His residues| cystatin family protein similar to cystatins which are a family of cysteine protease inhibitors
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Spp-24 | pfam07448 | Secreted phosphoprotein 24 (Spp-24) cystatin-like domain; This family represents a conserved ... |
67-129 | 8.12e-38 | ||
Secreted phosphoprotein 24 (Spp-24) cystatin-like domain; This family represents a conserved region approximately 60 residues long within secreted phosphoprotein 24 (Spp-24), which seems to be restricted to vertebrates. This is a non-collagenous protein found in bone that is related in sequence to the cystatin family of thiol protease inhibitors. This suggests that Spp-24 could function to modulate the thiol protease activities known to be involved in bone turnover. It is also possible that the intact form of Spp-24 found in bone could be a precursor to a biologically active peptide that coordinates an aspect of bone turnover. : Pssm-ID: 429466 Cd Length: 64 Bit Score: 124.92 E-value: 8.12e-38
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| CY super family | cl09238 | Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ... |
32-100 | 8.89e-04 | ||
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains. The actual alignment was detected with superfamily member pfam00031: Pssm-ID: 447698 Cd Length: 92 Bit Score: 36.93 E-value: 8.89e-04
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| Name | Accession | Description | Interval | E-value | |||
| Spp-24 | pfam07448 | Secreted phosphoprotein 24 (Spp-24) cystatin-like domain; This family represents a conserved ... |
67-129 | 8.12e-38 | |||
Secreted phosphoprotein 24 (Spp-24) cystatin-like domain; This family represents a conserved region approximately 60 residues long within secreted phosphoprotein 24 (Spp-24), which seems to be restricted to vertebrates. This is a non-collagenous protein found in bone that is related in sequence to the cystatin family of thiol protease inhibitors. This suggests that Spp-24 could function to modulate the thiol protease activities known to be involved in bone turnover. It is also possible that the intact form of Spp-24 found in bone could be a precursor to a biologically active peptide that coordinates an aspect of bone turnover. Pssm-ID: 429466 Cd Length: 64 Bit Score: 124.92 E-value: 8.12e-38
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| Cystatin | pfam00031 | Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ... |
32-100 | 8.89e-04 | |||
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included. Pssm-ID: 425431 Cd Length: 92 Bit Score: 36.93 E-value: 8.89e-04
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| CY | smart00043 | Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ... |
34-113 | 1.47e-03 | |||
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains. Pssm-ID: 214484 Cd Length: 107 Bit Score: 36.64 E-value: 1.47e-03
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| Name | Accession | Description | Interval | E-value | |||
| Spp-24 | pfam07448 | Secreted phosphoprotein 24 (Spp-24) cystatin-like domain; This family represents a conserved ... |
67-129 | 8.12e-38 | |||
Secreted phosphoprotein 24 (Spp-24) cystatin-like domain; This family represents a conserved region approximately 60 residues long within secreted phosphoprotein 24 (Spp-24), which seems to be restricted to vertebrates. This is a non-collagenous protein found in bone that is related in sequence to the cystatin family of thiol protease inhibitors. This suggests that Spp-24 could function to modulate the thiol protease activities known to be involved in bone turnover. It is also possible that the intact form of Spp-24 found in bone could be a precursor to a biologically active peptide that coordinates an aspect of bone turnover. Pssm-ID: 429466 Cd Length: 64 Bit Score: 124.92 E-value: 8.12e-38
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| Cystatin | pfam00031 | Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ... |
32-100 | 8.89e-04 | |||
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included. Pssm-ID: 425431 Cd Length: 92 Bit Score: 36.93 E-value: 8.89e-04
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| CY | smart00043 | Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ... |
34-113 | 1.47e-03 | |||
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains. Pssm-ID: 214484 Cd Length: 107 Bit Score: 36.64 E-value: 1.47e-03
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| Blast search parameters | ||||
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