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Conserved domains on  [gi|1958803623|ref|XP_038939992|]
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leucine-rich repeat-containing protein 73 isoform X2 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 2-131 4.80e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 63.66  E-value: 4.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803623   2 LGDE-AINLICGLlppdGAKSGLKELTLSANpGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTL 80
Cdd:COG5238   304 IGDEgAIALAEGL----QGNKTLHTLNLAYN-GIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTL 378

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958803623  81 EVLDLEGTGLTNQSAQTLLDMVENypTALRSLVLAENSISPELQQQICDLL 131
Cdd:COG5238   379 RELNLGKNNIGKQGAEALIDALQT--NRLHTLILDGNLIGAEAQQRLEQLL 427
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 2-131 4.80e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 63.66  E-value: 4.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803623   2 LGDE-AINLICGLlppdGAKSGLKELTLSANpGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTL 80
Cdd:COG5238   304 IGDEgAIALAEGL----QGNKTLHTLNLAYN-GIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTL 378

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958803623  81 EVLDLEGTGLTNQSAQTLLDMVENypTALRSLVLAENSISPELQQQICDLL 131
Cdd:COG5238   379 RELNLGKNNIGKQGAEALIDALQT--NRLHTLILDGNLIGAEAQQRLEQLL 427
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 19-132 4.70e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 60.45  E-value: 4.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803623  19 AKSGLKELTLSANpGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQTL 98
Cdd:cd00116   163 ANRDLKELNLANN-GIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAAL 241

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1958803623  99 LDMVENYPTALRSLVLAENSISPELQQQICDLLS 132
Cdd:cd00116   242 ASALLSPNISLLTLSLSCNDITDDGAKDLAEVLA 275
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 2-131 4.80e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 63.66  E-value: 4.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803623   2 LGDE-AINLICGLlppdGAKSGLKELTLSANpGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTL 80
Cdd:COG5238   304 IGDEgAIALAEGL----QGNKTLHTLNLAYN-GIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTL 378

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958803623  81 EVLDLEGTGLTNQSAQTLLDMVENypTALRSLVLAENSISPELQQQICDLL 131
Cdd:COG5238   379 RELNLGKNNIGKQGAEALIDALQT--NRLHTLILDGNLIGAEAQQRLEQLL 427
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 19-132 4.70e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 60.45  E-value: 4.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803623  19 AKSGLKELTLSANpGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQTL 98
Cdd:cd00116   163 ANRDLKELNLANN-GIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAAL 241

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1958803623  99 LDMVENYPTALRSLVLAENSISPELQQQICDLLS 132
Cdd:cd00116   242 ASALLSPNISLLTLSLSCNDITDDGAKDLAEVLA 275
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 2-122 1.81e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 59.03  E-value: 1.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803623   2 LGDEAINLICGLLPpdgAKSGLKELTLSANPgITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLE 81
Cdd:COG5238   192 IGDEGIEELAEALT---QNTTVTTLWLKRNP-IGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVE 267

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958803623  82 VLDLEGTGLTNQSAQTLLDMVENyPTALRSLVLAENSISPE 122
Cdd:COG5238   268 TLYLSGNQIGAEGAIALAKALQG-NTTLTSLDLSVNRIGDE 307
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 26-131 2.89e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 52.48  E-value: 2.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803623  26 LTLSANPgITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQTLLDMVENY 105
Cdd:COG5238   269 LYLSGNQ-IGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQEN 347

                          90       100
                  ....*....|....*....|....*.
gi 1958803623 106 PTaLRSLVLAENSISPELQQQICDLL 131
Cdd:COG5238   348 TT-LHSLDLSDNQIGDEGAIALAKYL 372
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 2-132 4.34e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 4.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803623   2 LGDEAINLICGLLPPdgaKSGLKELTLSAN-PGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAvAVASSRTL 80
Cdd:cd00116    35 LGEEAAKALASALRP---QPSLKELCLSLNeTGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLE-SLLRSSSL 110

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958803623  81 EVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENSISPELQQQICDLLS 132
Cdd:cd00116   111 QELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALR 162
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 2-120 8.04e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 8.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803623   2 LGDEAINLICGLLPPdgAKSGLKELTLSANpGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLE 81
Cdd:cd00116   120 LGDRGLRLLAKGLKD--LPPALEKLVLGRN-RLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLE 196

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1958803623  82 VLDLEGTGLTNQSAQTLLDMVENyPTALRSLVLAENSIS 120
Cdd:cd00116   197 VLDLNNNGLTDEGASALAETLAS-LKSLEVLNLGDNNLT 234
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 23-122 1.33e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 1.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803623  23 LKELTLSANPgITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQTLLDMV 102
Cdd:COG5238   238 LTTLDLSNNQ-IGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL 316

                          90       100
                  ....*....|....*....|
gi 1958803623 103 ENYPTaLRSLVLAENSISPE 122
Cdd:COG5238   317 QGNKT-LHTLNLAYNGIGAQ 335
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 2-96 1.27e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.49  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803623   2 LGDEAINLICGLLPpdgAKSGLKELTLSANPgITPKGWSRLAIAVAH-SSQVRVLNLDYNPLGDHVAGMLAVAVASSRTL 80
Cdd:cd00116   205 LTDEGASALAETLA---SLKSLEVLNLGDNN-LTDAGAAALASALLSpNISLLTLSLSCNDITDDGAKDLAEVLAEKESL 280

                          90
                  ....*....|....*.
gi 1958803623  81 EVLDLEGTGLTNQSAQ 96
Cdd:cd00116   281 LELDLRGNKFGEEGAQ 296
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
21-125 5.81e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 36.84  E-value: 5.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803623  21 SGLKELTLSANpGITpkgwsRLAIAVAHSSQVRVLNLDYNPLGDhvagmLAVAVASSRTLEVLDLEGTGLTNQSAQtLLD 100
Cdd:COG4886   159 TNLKSLDLSNN-QLT-----DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTDLPEP-LAN 226

                          90       100
                  ....*....|....*....|....*..
gi 1958803623 101 MvenypTALRSLVLAENSIS--PELQQ 125
Cdd:COG4886   227 L-----TNLETLDLSNNQLTdlPELGN 248
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 4-122 8.49e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 36.31  E-value: 8.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803623   4 DEAINLICGLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQ------VRVLNLDYNPLGDHVAGMLAVAVASS 77
Cdd:COG5238   128 EDSLILYLALPRRINLIQVLKDPLGGNAVHLLGLAARLGLLAAISMAKalqnnsVETVYLGCNQIGDEGIEELAEALTQN 207

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1958803623  78 RTLEVLDLEGTGLTNQSAQTLLDMV-ENypTALRSLVLAENSISPE 122
Cdd:COG5238   208 TTVTTLWLKRNPIGDEGAEILAEALkGN--KSLTTLDLSNNQIGDE 251
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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