NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958803521|ref|XP_038939941|]
View 

solute carrier organic anion transporter family, member 6d1 isoform X12 [Rattus norvegicus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 84-321 2.24e-57

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17405:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 428  Bit Score: 192.76  E-value: 2.24e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521  84 INCFLTAYFLGTMAHGMIFGLVDQSLKVYVSELSPSKLETLTMGSGDDLAAFLVSLVGAHFGGRGNRVRWMVAACFVTGL 163
Cdd:cd17405     1 IDGFMILYCILVLIQGAVFGLVDMSIGIFQVQFSLTRTEKYLLDFSYDISSFLVAIIIAHYGSRGNRTRWIAASCFLMGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 164 ASMVFAIPFFNYEIIklgtvtdelciegkkttkvcertviphkstciaffnfGQFLHGIAGMPFYLLAFSFIFDHVPTCS 243
Cdd:cd17405    81 GSMLFAFPFFTFHIA-------------------------------------GQCIQGIAGMPIYILGITFIFDNIPTSS 123

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958803521 244 SGLYLAIADTALSVGYVLGYLVGIRNRMFPVKEDMKAVGHVQQFRILQRNWWRSYFAVAVFAFCTTLPLSCFPSRLRG 321
Cdd:cd17405   124 AGIYLGIAHSAYLIGYLLGYVGGLPNFQPPPNEKSVEIEVNKVYQLWQSGWWKTFLIAAAIAWCTSFPLVCFPTSLPG 201
 
Name Accession Description Interval E-value
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
 84-321 2.24e-57

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 192.76  E-value: 2.24e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521  84 INCFLTAYFLGTMAHGMIFGLVDQSLKVYVSELSPSKLETLTMGSGDDLAAFLVSLVGAHFGGRGNRVRWMVAACFVTGL 163
Cdd:cd17405     1 IDGFMILYCILVLIQGAVFGLVDMSIGIFQVQFSLTRTEKYLLDFSYDISSFLVAIIIAHYGSRGNRTRWIAASCFLMGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 164 ASMVFAIPFFNYEIIklgtvtdelciegkkttkvcertviphkstciaffnfGQFLHGIAGMPFYLLAFSFIFDHVPTCS 243
Cdd:cd17405    81 GSMLFAFPFFTFHIA-------------------------------------GQCIQGIAGMPIYILGITFIFDNIPTSS 123

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958803521 244 SGLYLAIADTALSVGYVLGYLVGIRNRMFPVKEDMKAVGHVQQFRILQRNWWRSYFAVAVFAFCTTLPLSCFPSRLRG 321
Cdd:cd17405   124 AGIYLGIAHSAYLIGYLLGYVGGLPNFQPPPNEKSVEIEVNKVYQLWQSGWWKTFLIAAAIAWCTSFPLVCFPTSLPG 201
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 86-359 2.76e-38

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 143.88  E-value: 2.76e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521  86 CFLTAYFLGTMAHGMIFGLVDQSL----KVYvsELSPSklETLTMGSGDDLAAFLVSLVGAHFGGRGNRVRWMVAACFVT 161
Cdd:pfam03137   1 FFLVFLSLLGLAQALVSGYFNSSIttieKRF--GLPSS--LSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLM 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 162 GLASMVFAIPFFnyeiiklgtvtdelciegkkttkvcertviphkstcIAFFnFGQFLHGIAGMPFYLLAFSFIFDHVPT 241
Cdd:pfam03137  77 GLGSLLFALPHF------------------------------------LSFF-LGQLLLGIGGTPIYTLGISYIDDNVKK 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 242 CSSGLYLAIADTALSVGYVLGYLVG---IRNRMFPVK-------EDMKAVGhvqqfrilqrNWWRSYFAVAVFAFCTTLP 311
Cdd:pfam03137 120 KNSPLYLGILYAVRVLGPALGFLLGslcLRIYVDIGKvsitltpKDPRWVG----------AWWLGFLIAGLLLLLTAIP 189

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958803521 312 LSCFPSRLRGAQQIRLEKSKEPPTIDRR-----LKDKEIQPGLKGVLHAIWAL 359
Cdd:pfam03137 190 FFFFPKSLPGAAKRRAKKKKEPHSQDIAdlkktKSLKKLGPSLKDFPKALKRL 242
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 64-353 2.92e-16

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 80.16  E-value: 2.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521  64 EEGSFGLGPLVfPCLQ-RFNNINCFLTAYFLGTMAHGMIFGLVDQSL-KVYVSELSPSKLETLTMGSGDdLAAFLVSLVG 141
Cdd:TIGR00805  11 HESSAGLKPRP-RCLQsLFSKIKMFSLLLTCARLQGLLVNGLVNSMLtSIERRFKIPTSRSGFINGSYE-IGNLLLIIFV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 142 AHFGGRGNRVRWMVAACFVTGLASMVFAIPFF-----NYE--IIKLGTVT---DELCIEGK----KTTKVCERTVIPHKS 207
Cdd:TIGR00805  89 SYFGTKLHRPIVIGAGCAIMGLGSLLSSLPHFlmgrySYSttVSSTGNLSsanSFLCMENLtqtlRPTQDPSECQKQHKS 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 208 TCIAFFNFGQFLHGIAGMPFYLLAFSFIFDHVPTCSSGLYLAIADTALSVGYVLGYLVG-IRNRMF----PVKEDMKAVG 282
Cdd:TIGR00805 169 LMWLLFLVSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGsFCLQIYvdtgSVNTEDLIIT 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 283 HVQQFRIlqRNWWRSYFAVAVFAFCTTLPLSCFPSRL---------RGAQQIRLEKSKEPPTIDRRLKDKEIQPGLKGVL 353
Cdd:TIGR00805 249 PTDPRWI--GAWWIGFLVCGFVALLTSIPLFFFPKTLpkegkrvnvDVHEAEKLEKSRGEDRKKNSGITKDFPKFIKRLL 326
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
88-378 8.07e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.19  E-value: 8.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521  88 LTAYFLGTMAHGMIFGLVDQSLKVYVSELSPSKLETLTMGSGDDLAAFLVSLVGAHFGGRGNRVRWMVAACFVTGLASMV 167
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 168 FAIpffnyeiiklgtvtdelciegkkttkvcertviphkSTCIAFFNFGQFLHGIAGMPFYLLAFSFIFDHVPTCSSGLY 247
Cdd:COG2814    92 CAL------------------------------------APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRA 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 248 LAIADTALSVGYVLGYLVGIrnrmfpvkedmkavghvqqfRILQRNWWRSYFAVAVFAFCttlpLSCFPSRLRGAQQIRL 327
Cdd:COG2814   136 LGLLGAGLGLGPALGPLLGG--------------------LLADLFGWRWVFLVNAVLAL----LALLLLLRLLPESRPA 191

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958803521 328 EKSKEPPTIDRRLKDKEIQPGLkgVLHAIWALRNMGFPLSIPFSASHKFGV 378
Cdd:COG2814   192 ARARLRGSLRELLRRPRLLLLL--LLAFLLGFGFFALFTYLPLYLQEVLGL 240
 
Name Accession Description Interval E-value
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
 84-321 2.24e-57

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 192.76  E-value: 2.24e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521  84 INCFLTAYFLGTMAHGMIFGLVDQSLKVYVSELSPSKLETLTMGSGDDLAAFLVSLVGAHFGGRGNRVRWMVAACFVTGL 163
Cdd:cd17405     1 IDGFMILYCILVLIQGAVFGLVDMSIGIFQVQFSLTRTEKYLLDFSYDISSFLVAIIIAHYGSRGNRTRWIAASCFLMGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 164 ASMVFAIPFFNYEIIklgtvtdelciegkkttkvcertviphkstciaffnfGQFLHGIAGMPFYLLAFSFIFDHVPTCS 243
Cdd:cd17405    81 GSMLFAFPFFTFHIA-------------------------------------GQCIQGIAGMPIYILGITFIFDNIPTSS 123

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958803521 244 SGLYLAIADTALSVGYVLGYLVGIRNRMFPVKEDMKAVGHVQQFRILQRNWWRSYFAVAVFAFCTTLPLSCFPSRLRG 321
Cdd:cd17405   124 AGIYLGIAHSAYLIGYLLGYVGGLPNFQPPPNEKSVEIEVNKVYQLWQSGWWKTFLIAAAIAWCTSFPLVCFPTSLPG 201
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 86-359 2.76e-38

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 143.88  E-value: 2.76e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521  86 CFLTAYFLGTMAHGMIFGLVDQSL----KVYvsELSPSklETLTMGSGDDLAAFLVSLVGAHFGGRGNRVRWMVAACFVT 161
Cdd:pfam03137   1 FFLVFLSLLGLAQALVSGYFNSSIttieKRF--GLPSS--LSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLM 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 162 GLASMVFAIPFFnyeiiklgtvtdelciegkkttkvcertviphkstcIAFFnFGQFLHGIAGMPFYLLAFSFIFDHVPT 241
Cdd:pfam03137  77 GLGSLLFALPHF------------------------------------LSFF-LGQLLLGIGGTPIYTLGISYIDDNVKK 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 242 CSSGLYLAIADTALSVGYVLGYLVG---IRNRMFPVK-------EDMKAVGhvqqfrilqrNWWRSYFAVAVFAFCTTLP 311
Cdd:pfam03137 120 KNSPLYLGILYAVRVLGPALGFLLGslcLRIYVDIGKvsitltpKDPRWVG----------AWWLGFLIAGLLLLLTAIP 189

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958803521 312 LSCFPSRLRGAQQIRLEKSKEPPTIDRR-----LKDKEIQPGLKGVLHAIWAL 359
Cdd:pfam03137 190 FFFFPKSLPGAAKRRAKKKKEPHSQDIAdlkktKSLKKLGPSLKDFPKALKRL 242
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 84-316 4.67e-23

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 99.62  E-value: 4.67e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521  84 INCFLTAYFLGTMAHGMIFGLvdqslkvYVSELSPS----KLETLTMG---SGDDLAAFLVSLVGAHFGGRGNRVRWMVA 156
Cdd:cd17336     1 PKVFVVLLCLLGLLQGAVVSY-------FVSTITTIekrfGLSSSQSGlilSANDIGQLLAVLLVSYFGGRGHRPRWIGI 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 157 ACFVTGLASMVFAIPFFnyeiiklgtvtdelciegkkttkvcertviphkstciafFNFGQFLHGIAGMPFYLLAFSFIF 236
Cdd:cd17336    74 GSILMGLGCFLLALPHF---------------------------------------LFVGQFLLGIGSSPLYTLGITYID 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 237 DHVPTCSSGLYLAIADTALSVGYVLGYLVG-IRNRMF---------PVKEDMKAVGhvqqfrilqrNWWRSYFAVAVFAF 306
Cdd:cd17336   115 DNVSKKNSPLYIGILYAMRVLGPALGFLLGsFLLRIYvdfsrvplgITPDDPRWIG----------AWWLGFLILGILLL 184

                         250
                  ....*....|
gi 1958803521 307 CTTLPLSCFP 316
Cdd:cd17336   185 IVSIPLFFFP 194
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
 86-316 6.96e-20

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 90.39  E-value: 6.96e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521  86 CFLTAYFLGTMAHGMIF-GLVDQSL----KVYvsELSPSklETLTMGSGDDLAAFLVSLVGAHFGGRGNRVRWMVAACFV 160
Cdd:cd17403     3 GFLFFLCIFAFLQGMVVnGFVNVSIttieKRF--GLTST--QTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 161 TGLASMVFAIPFFnyeiiklgtvtdelciegkkttkvcerTViphkstciafFNFGQFLHGIAGMPFYLLAFSFIFDHVP 240
Cdd:cd17403    79 MGIGSLVFALPHF---------------------------TV----------FILAQLLHGAGATPLYTLGVTYLDENVS 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 241 TCSSGLYLAIADTALSVGYVLGYLVG-----------IRNRMFPVK-EDMKAVGhvqqfrilqrNWWRSYFAVAVFAFCT 308
Cdd:cd17403   122 TKMSPLYIGIFYAMAILGPAIGYVLGgfllnlytdidQVDSELGLTpDDPRWVG----------AWWLGFLISGALALII 191


                  ....*...
gi 1958803521 309 TLPLSCFP 316
Cdd:cd17403   192 AFPLLGFP 199
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
 87-321 6.55e-19

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 87.49  E-value: 6.55e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521  87 FLTAYFLGTMAHGMIF-GLVDQSLKVYVSELSPSKLETLTMGSGDDLAAFLVSLVGAHFGGRGNRVRWMVAACFVTGLAS 165
Cdd:cd17463     4 YLLFYSLLAVVQGIVVnGLVNISISTIEKRYELSSSLTGLISSSYDISFCLLSLFVSFYGERGHKPRWLAFSAFMIGLGS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 166 MVFAIPFFNyeiiklgtvtdelciegkkttkvcertviphkstciaFFNFGQFLHGIAGMPFYLLAFSFIFDHVPTCSSG 245
Cdd:cd17463    84 LVFSLPHFF-------------------------------------VFILGQLLLGVGGTPLYTLGTAYIDDSVPTHKSS 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 246 LYLAIAdTALSV-GYVLGYLVGirNRMFPVKEDMKAVGHVQqfriLQRN-------WWRSYFAVAVFAFCTTLPLSCFPS 317
Cdd:cd17463   127 LYIGIG-YGMSVlGPAIGYLLG--GQLLNIYIDVNKGQSVD----LTEEdprwlgaWWIGFLMCWLIAWCLIAPFSCFPK 199


                  ....
gi 1958803521 318 RLRG 321
Cdd:cd17463   200 HLPG 203
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 64-353 2.92e-16

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 80.16  E-value: 2.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521  64 EEGSFGLGPLVfPCLQ-RFNNINCFLTAYFLGTMAHGMIFGLVDQSL-KVYVSELSPSKLETLTMGSGDdLAAFLVSLVG 141
Cdd:TIGR00805  11 HESSAGLKPRP-RCLQsLFSKIKMFSLLLTCARLQGLLVNGLVNSMLtSIERRFKIPTSRSGFINGSYE-IGNLLLIIFV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 142 AHFGGRGNRVRWMVAACFVTGLASMVFAIPFF-----NYE--IIKLGTVT---DELCIEGK----KTTKVCERTVIPHKS 207
Cdd:TIGR00805  89 SYFGTKLHRPIVIGAGCAIMGLGSLLSSLPHFlmgrySYSttVSSTGNLSsanSFLCMENLtqtlRPTQDPSECQKQHKS 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 208 TCIAFFNFGQFLHGIAGMPFYLLAFSFIFDHVPTCSSGLYLAIADTALSVGYVLGYLVG-IRNRMF----PVKEDMKAVG 282
Cdd:TIGR00805 169 LMWLLFLVSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGsFCLQIYvdtgSVNTEDLIIT 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 283 HVQQFRIlqRNWWRSYFAVAVFAFCTTLPLSCFPSRL---------RGAQQIRLEKSKEPPTIDRRLKDKEIQPGLKGVL 353
Cdd:TIGR00805 249 PTDPRWI--GAWWIGFLVCGFVALLTSIPLFFFPKTLpkegkrvnvDVHEAEKLEKSRGEDRKKNSGITKDFPKFIKRLL 326
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
 126-321 6.25e-15

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 75.64  E-value: 6.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 126 MGSGDDLAAFLVSLVGAHFGGRGNRVRWMVAACFVTGLASMVFAIPFFnyeiiklgtvtdelciegkkttkvcerTViph 205
Cdd:cd17462    44 IASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLIMGLGSLVFALPHF---------------------------TV--- 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 206 kstciafFNFGQFLHGIAGMPFYLLAFSFIFDHVPTCSSGLYLAIADTALSVGYVLGYLVG---------IRNRMFPVKE 276
Cdd:cd17462    94 -------FMLGQFLHGIGATPLYTLGVTYLDENVKSNYSPVYIGIFYTAAIVGPAAGYLLGgfflniyteIGRQTELTPE 166

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1958803521 277 DMKAVGhvqqfrilqrNWWRSYFAVAVFAFCTTLPLSCFPSRLRG 321
Cdd:cd17462   167 NPLWVG----------AWWIGFLGAGAAALLIALPILGYPRQLPG 201
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
 86-316 1.58e-12

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 68.53  E-value: 1.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521  86 CFLTAyFLGTMAHGMIFGLVDQSLKVYvsELSPSKLETLTmgSGDDLAAFLVSLVGAHFGGRGNRVRWMVAACFVTGLAS 165
Cdd:cd17404     8 CLLIF-IQSALSSGYLNSVITTIEKRY--SLKSSESGLIV--SSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIALGS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 166 MVFAIPffnyeiiklgtvtdelciegkkttkvcertvipHkstciaFFNFGQFLHGIAGMPFYLLAFSFIFDHVPTCSSG 245
Cdd:cd17404    83 FLFSLP---------------------------------H------FFILAQILIGMGGTPIFTLGTTYLDDHVKKESSS 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 246 LYLAIADTALSVGYVLGYLVG-------IRNRMFPVK---EDMKAVGhvqqfrilqrNWWRSYFAVAVFAFCTTLPLSCF 315
Cdd:cd17404   124 LYLAIMYVMGALGPAAGFLLGgllinfyVDPLSTPPDispGDPRWIG----------AWWGGFLLCGIALLLVAFPFFTF 193


                  .
gi 1958803521 316 P 316
Cdd:cd17404   194 P 194
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
 118-266 6.18e-05

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 44.76  E-value: 6.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 118 PSKLETLTMGSGDdLAAFLVSLVGAHFGGRGNRVRWMVAACFVTGLASMVFAIPFFNYEIIKLGT---------VTDELC 188
Cdd:cd17459    36 PSSLIGVIDGSFE-MGNLLVIAFVSYFGAKLHRPRIIGAGCLLMAIGTFLIALPHFFMGRYKYETaiqsssnstVSISPC 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 189 IEGK------------KTTKVCERTviPHKSTCIAFFnFGQFLHGIAGMPFYLLAFSFIFDHVPTCSSGLYLAIADTALS 256
Cdd:cd17459   115 SLEPspqlhsiessdsKTGTGCEKE--PGSSMWIYVF-LGNLLRGIGETPVQPLGISYIDDFAKEENAAFYIGCVQTIAI 191

                         170
                  ....*....|
gi 1958803521 257 VGYVLGYLVG 266
Cdd:cd17459   192 IGPVFGFLLG 201
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
 118-319 7.05e-05

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 44.84  E-value: 7.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 118 PSKLETLTMGS---GDDLAAFLVSlvgaHFGGRGNRVRWMVAACFVTGLASMVFAIPFF---NYEIIKLGTVTDE----- 186
Cdd:cd17458    37 PSSLVGIINGSfeiGNLLVIAFVS----YFGAKLHRPKVIGLGCLIMSLGCFLASLPHFlmgRYEYESTVSTTSNsssrv 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 187 -LCIEGKKTTKV-------CERTViphKSTCIAFFNFGQFLHGIAGMPFYLLAFSFIFDHVPTCSSGLYLAIADTALSVG 258
Cdd:cd17458   113 pLCLANQSLSHNvtqlpseCEKES---MSLMWIFVLVGNLLRGIGETPVMPLGISYIDDFSKKENSPFYIGCLHTATIVG 189

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958803521 259 YVLGYLVGIRNRMFPVkeDMKAVGhVQQFRILQRN------WWRSYFAVAVFAFCTTLPLSCFPSRL 319
Cdd:cd17458   190 PLLGLLLASFCAQLYV--DLGSVN-ADDLTITPTDirwvgaWWLGFLICAGVNFLAGLPFWFLPKSL 253
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
88-378 8.07e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.19  E-value: 8.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521  88 LTAYFLGTMAHGMIFGLVDQSLKVYVSELSPSKLETLTMGSGDDLAAFLVSLVGAHFGGRGNRVRWMVAACFVTGLASMV 167
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 168 FAIpffnyeiiklgtvtdelciegkkttkvcertviphkSTCIAFFNFGQFLHGIAGMPFYLLAFSFIFDHVPTCSSGLY 247
Cdd:COG2814    92 CAL------------------------------------APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRA 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 248 LAIADTALSVGYVLGYLVGIrnrmfpvkedmkavghvqqfRILQRNWWRSYFAVAVFAFCttlpLSCFPSRLRGAQQIRL 327
Cdd:COG2814   136 LGLLGAGLGLGPALGPLLGG--------------------LLADLFGWRWVFLVNAVLAL----LALLLLLRLLPESRPA 191

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958803521 328 EKSKEPPTIDRRLKDKEIQPGLkgVLHAIWALRNMGFPLSIPFSASHKFGV 378
Cdd:COG2814   192 ARARLRGSLRELLRRPRLLLLL--LLAFLLGFGFFALFTYLPLYLQEVLGL 240
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
 131-316 1.23e-03

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 40.60  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 131 DLAAFLVSLVGAHFGGRGNRVRWMVAACFVTGLASMVFAIPFFNYEIIKLGTVTDElciegkkttkvcertviphKSTCI 210
Cdd:cd17457    48 EIGNLLVIAFVSYFGAKLHRPKLIAAGCFIMGLGSVLTALPHFFMGYYKYGCLKES-------------------GSYMW 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 211 AFFNFGQFLHGIAGMPFYLLAFSFIFDHVPTCSSGLYLAIADTALSVGYVLGYLVG-IRNRMFpvkedmKAVGHVQ--QF 287
Cdd:cd17457   109 VYVLMGNMLRGIGETPIVPLGISYLDDFAKEENSPLYLACLHTIAMIGPMIGFTLGsLFAKLY------VDIGFVDlsTI 182

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1958803521 288 RILQRN------WWRSYFAVAVFAFCTTLPLSCFP 316
Cdd:cd17457   183 RITPQDsrwvgaWWLGFLVSGLFSIISAIPFFFLP 217
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 88-322 1.87e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 39.79  E-value: 1.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521  88 LTAYFLGTMAHGMIFGLVDQSLKVYVSELSPSKLETLTMGSGDDLAAFLVSLVGAHFGGRGNRVRWMVAACFVTGLASMV 167
Cdd:COG0477    16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958803521 168 FAIpffnyeiiklgtvtdelciegkkttkvcertviphkSTCIAFFNFGQFLHGIAGMPFYLLAFSFIFDHVPTCSSGLY 247
Cdd:COG0477    96 CGL------------------------------------APSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRA 139

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958803521 248 LAIADTALSVGYVLGYLVGirnrmfpvkedmkavghvqqFRILQRNWWRSYFAVAVFAFCTTLPLSCFPSRLRGA 322
Cdd:COG0477   140 LGLWGAAIGLGLALGPLLG--------------------GLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGL 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH