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Conserved domains on  [gi|1958647676|ref|XP_038939151|]
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mitotic checkpoint protein BUB3 isoform X1 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-216 6.78e-22

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.05  E-value: 6.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676  15 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEK-VYTLSVS--GDRLIVGTAGRRVLVWDLRNmgyvq 91
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSpdGKLLASGSADGTVRLWDLAT----- 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676  92 QRRESSLKYQTRCIR--AF-PNKQGYVLSSIEGRVAVEYLDPSPEVqkkkyafkcHRLKENNieqiYPVNAISFHNIHNT 168
Cdd:COG2319   236 GKLLRTLTGHSGSVRsvAFsPDGRLLASGSADGTVRLWDLATGELL---------RTLTGHS----GGVNSVAFSPDGKL 302

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1958647676 169 FATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 216
Cdd:COG2319   303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-216 6.78e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.05  E-value: 6.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676  15 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEK-VYTLSVS--GDRLIVGTAGRRVLVWDLRNmgyvq 91
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSpdGKLLASGSADGTVRLWDLAT----- 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676  92 QRRESSLKYQTRCIR--AF-PNKQGYVLSSIEGRVAVEYLDPSPEVqkkkyafkcHRLKENNieqiYPVNAISFHNIHNT 168
Cdd:COG2319   236 GKLLRTLTGHSGSVRsvAFsPDGRLLASGSADGTVRLWDLATGELL---------RTLTGHS----GGVNSVAFSPDGKL 302

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1958647676 169 FATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 216
Cdd:COG2319   303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-216 5.48e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.54  E-value: 5.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676   3 DLNTDQEN--LVGtHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEK-VYTLSVSGDRLIVGTAG--R 77
Cdd:cd00200    79 DLETGECVrtLTG-HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwVNSVAFSPDGTFVASSSqdG 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676  78 RVLVWDLRNMGYVQQRR--ESSLkyqtRCIRAFPNKQGYVLSSIEGRVAVeyLDPSpeVQKKKYAFKCHRlkennieqiY 155
Cdd:cd00200   158 TIKLWDLRTGKCVATLTghTGEV----NSVAFSPDGEKLLSSSSDGTIKL--WDLS--TGKCLGTLRGHE---------N 220

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958647676 156 PVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 216
Cdd:cd00200   221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 15-44 1.48e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 1.48e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958647676   15 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWD 44
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
15-44 3.64e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 3.64e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958647676  15 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWD 44
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-216 6.78e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.05  E-value: 6.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676  15 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEK-VYTLSVS--GDRLIVGTAGRRVLVWDLRNmgyvq 91
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSpdGKLLASGSADGTVRLWDLAT----- 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676  92 QRRESSLKYQTRCIR--AF-PNKQGYVLSSIEGRVAVEYLDPSPEVqkkkyafkcHRLKENNieqiYPVNAISFHNIHNT 168
Cdd:COG2319   236 GKLLRTLTGHSGSVRsvAFsPDGRLLASGSADGTVRLWDLATGELL---------RTLTGHS----GGVNSVAFSPDGKL 302

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1958647676 169 FATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 216
Cdd:COG2319   303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350
WD40 COG2319
WD40 repeat [General function prediction only];
15-216 1.13e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.59  E-value: 1.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676  15 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFS-QPEKVYTLSVS--GDRLIVGTAGRRVLVWDLRNmgyvq 91
Cdd:COG2319   203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSpdGRLLASGSADGTVRLWDLAT----- 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676  92 QRRESSLKYQTRCIR--AF-PNKQGYVLSSIEGRVAVEYLDPSPEVQkkkyAFKCHrlkennieqIYPVNAISFHNIHNT 168
Cdd:COG2319   278 GELLRTLTGHSGGVNsvAFsPDGKLLASGSDDGTVRLWDLATGKLLR----TLTGH---------TGAVRSVAFSPDGKT 344

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1958647676 169 FATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 216
Cdd:COG2319   345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
WD40 COG2319
WD40 repeat [General function prediction only];
3-216 3.21e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 3.21e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676   3 DLNTDQENLVGT-HDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFS-QPEKVYTLSVS--GDRLIVGTAGRR 78
Cdd:COG2319   106 DLATGLLLRTLTgHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSpdGKLLASGSDDGT 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676  79 VLVWDLRNmgyvqQRRESSLKYQTRCIR--AF-PNKQGYVLSSIEGRVAVEYLDPSPEVQKkkyaFKCHRlkennieqiY 155
Cdd:COG2319   186 VRLWDLAT-----GKLLRTLTGHTGAVRsvAFsPDGKLLASGSADGTVRLWDLATGKLLRT----LTGHS---------G 247

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958647676 156 PVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 216
Cdd:COG2319   248 SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD 308
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-216 5.48e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.54  E-value: 5.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676   3 DLNTDQEN--LVGtHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEK-VYTLSVSGDRLIVGTAG--R 77
Cdd:cd00200    79 DLETGECVrtLTG-HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwVNSVAFSPDGTFVASSSqdG 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676  78 RVLVWDLRNMGYVQQRR--ESSLkyqtRCIRAFPNKQGYVLSSIEGRVAVeyLDPSpeVQKKKYAFKCHRlkennieqiY 155
Cdd:cd00200   158 TIKLWDLRTGKCVATLTghTGEV----NSVAFSPDGEKLLSSSSDGTIKL--WDLS--TGKCLGTLRGHE---------N 220

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958647676 156 PVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 216
Cdd:cd00200   221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281
WD40 COG2319
WD40 repeat [General function prediction only];
15-216 1.87e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 1.87e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676  15 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFS-QPEKVYTLSVS--GDRLIVGTAGRRVLVWDLRNmgyvq 91
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSpdGKTLASGSADGTVRLWDLAT----- 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676  92 QRRESSLKYQTRCIR--AF-PNKQGYVLSSIEGRVAVEYLDPSPEVQkkkyAFKCHRlkennieqiYPVNAISFHNIHNT 168
Cdd:COG2319   152 GKLLRTLTGHSGAVTsvAFsPDGKLLASGSDDGTVRLWDLATGKLLR----TLTGHT---------GAVRSVAFSPDGKL 218

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1958647676 169 FATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 216
Cdd:COG2319   219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-215 2.59e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.61  E-value: 2.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676   3 DLNTDQENLVGT-HDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEK-VYTLSVSGDRLIVGTAGR--R 78
Cdd:cd00200    37 DLETGELLRTLKgHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSyVSSVAFSPDGRILSSSSRdkT 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676  79 VLVWDLRNmgyvqqrresslkyqTRCIRAFPNKQGYVLSsiegrvaveyLDPSPEvqkKKYAF-----KCHRLKENNIEQ 153
Cdd:cd00200   117 IKVWDVET---------------GKCLTTLRGHTDWVNS----------VAFSPD---GTFVAsssqdGTIKLWDLRTGK 168

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676 154 IY--------PVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIAS 215
Cdd:cd00200   169 CVatltghtgEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGS 238
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-216 1.43e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.29  E-value: 1.43e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676  15 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWD------PRTPCNAgtfSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNmG 88
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDletgelLRTLKGH---TGPVRDVAASADGTYLASGSSDKTIRLWDLET-G 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676  89 YVQQRRESSLKYqTRCIRAFPNKQgYVLSSIE-GRVAVEYLDPSpevqKKKYAFKCHRlkennieqiYPVNAISFHnIHN 167
Cdd:cd00200    84 ECVRTLTGHTSY-VSSVAFSPDGR-ILSSSSRdKTIKVWDVETG----KCLTTLRGHT---------DWVNSVAFS-PDG 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958647676 168 TFATGGS-DGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 216
Cdd:cd00200   148 TFVASSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197
WD40 COG2319
WD40 repeat [General function prediction only];
3-183 2.03e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 2.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676   3 DLNTDQE-NLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFS-QPEKVYTLSVS--GDRLIVGTAGRR 78
Cdd:COG2319   274 DLATGELlRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSpdGKTLASGSDDGT 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676  79 VLVWDLRNmgyvqqrresslkyqTRCIRAFPNKQGyvlssiegrvaveyldpspevqkkkyafkchrlkennieqiyPVN 158
Cdd:COG2319   354 VRLWDLAT---------------GELLRTLTGHTG------------------------------------------AVT 376

                         170       180
                  ....*....|....*....|....*
gi 1958647676 159 AISFHNIHNTFATGGSDGFVNIWDP 183
Cdd:COG2319   377 SVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
15-86 6.55e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 6.55e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958647676  15 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEK-VYTLSVS--GDRLIVGTAGRRVLVWDLRN 86
Cdd:COG2319   329 HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGaVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
32-216 1.26e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.61  E-value: 1.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676  32 VTGSWDQTVKLWDPRTPCNAGTFS-QPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPN 110
Cdd:COG2319    10 AAASADLALALLAAALGALLLLLLgLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647676 111 KQGYVLSSIEGRVAVEYLDPSPEVQkkkyAFKCHRlkennieqiYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLC 190
Cdd:COG2319    90 GRLLASASADGTVRLWDLATGLLLR----TLTGHT---------GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156

                         170       180
                  ....*....|....*....|....*.
gi 1958647676 191 QFHRYPTSIASLAFSNDGTTLAIASS 216
Cdd:COG2319   157 TLTGHSGAVTSVAFSPDGKLLASGSD 182
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 15-44 1.48e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 1.48e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958647676   15 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWD 44
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
15-44 3.64e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 3.64e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958647676  15 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWD 44
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-44 1.06e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 1.06e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1958647676   3 DLNTDQENLVGT-HDAPIRCVEYCPEVNVMVTGSWDQTVKLWD 44
Cdd:cd00200   247 DLRTGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 156-182 1.50e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 1.50e-04
                           10        20
                   ....*....|....*....|....*..
gi 1958647676  156 PVNAISFHNIHNTFATGGSDGFVNIWD 182
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
3-47 3.30e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.44  E-value: 3.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958647676   3 DLNTDQE--NLVGtHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRT 47
Cdd:COG2319   358 DLATGELlrTLTG-HTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 pfam00400
WD domain, G-beta repeat;
156-182 1.56e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 1.56e-03
                          10        20
                  ....*....|....*....|....*..
gi 1958647676 156 PVNAISFHNIHNTFATGGSDGFVNIWD 182
Cdd:pfam00400  13 SVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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