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Conserved domains on  [gi|1958797686|ref|XP_038937963|]
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ATP-dependent RNA helicase DDX25 isoform X2 [Rattus norvegicus]

Protein Classification

DEAD/DEAH box helicase family protein( domain architecture ID 1000205)

DEAD/DEAH box helicase family protein such as a DEAD/DEAH box-containing ATP-dependent helicase, which catalyzes the unwinding of DNA or RNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEAD-like_helicase_N super family cl28899
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ...
 80-266 6.79e-129

N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.


The actual alignment was detected with superfamily member cd18048:

Pssm-ID: 475120 [Multi-domain]  Cd Length: 229  Bit Score: 365.50  E-value: 6.79e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686  80 HRVEVLQKDPSSPLYSVKTFEELRLKEELLKGIYAMGFNRPSKIQEMALPMMLAHPPQNLIAQSQSGTGKTAAFVLAMLS 159
Cdd:cd18048     1 HRVEVLQRDPTSPLFSVKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADPPQNLIAQSQSGTGKTAAFVLAMLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 160 RVNALELFPQCLCLAPTYELALQTGRVVERMGKFCVDVEVMYAIRGNRIPRGTDVTKQIVIGTPGTVLDWCFKRKLIDLT 239
Cdd:cd18048    81 RVDALKLYPQCLCLSPTFELALQTGKVVEEMGKFCVGIQVIYAIRGNRPGKGTDIEAQIVIGTPGTVLDWCFKLRLIDVT 160

                         170       180
                  ....*....|....*....|....*..
gi 1958797686 240 KIRVFVLDEADVMIDTQGFSDQSIRIQ 266
Cdd:cd18048   161 NISVFVLDEADVMINVQGHSDHSVRVK 187
 
Name Accession Description Interval E-value
DEADc_DDX25 cd18048
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ...
 80-266 6.79e-129

DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350806 [Multi-domain]  Cd Length: 229  Bit Score: 365.50  E-value: 6.79e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686  80 HRVEVLQKDPSSPLYSVKTFEELRLKEELLKGIYAMGFNRPSKIQEMALPMMLAHPPQNLIAQSQSGTGKTAAFVLAMLS 159
Cdd:cd18048     1 HRVEVLQRDPTSPLFSVKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADPPQNLIAQSQSGTGKTAAFVLAMLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 160 RVNALELFPQCLCLAPTYELALQTGRVVERMGKFCVDVEVMYAIRGNRIPRGTDVTKQIVIGTPGTVLDWCFKRKLIDLT 239
Cdd:cd18048    81 RVDALKLYPQCLCLSPTFELALQTGKVVEEMGKFCVGIQVIYAIRGNRPGKGTDIEAQIVIGTPGTVLDWCFKLRLIDVT 160

                         170       180
                  ....*....|....*....|....*..
gi 1958797686 240 KIRVFVLDEADVMIDTQGFSDQSIRIQ 266
Cdd:cd18048   161 NISVFVLDEADVMINVQGHSDHSVRVK 187
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
114-261 1.20e-41

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 148.37  E-value: 1.20e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 114 AMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNA-LELFPQCLCLAPTYELALQTGRVVERMGK 192
Cdd:COG0513    19 ELGYTTPTPIQAQAIPLILAG--RDVLGQAQTGTGKTAAFLLPLLQRLDPsRPRAPQALILAPTRELALQVAEELRKLAK 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958797686 193 FC-VDVEVMYairGnriprGTDVTKQ---------IVIGTPGTVLDWcFKRKLIDLTKIRVFVLDEADVMIDtQGFSDQ 261
Cdd:COG0513    97 YLgLRVATVY---G-----GVSIGRQiralkrgvdIVVATPGRLLDL-IERGALDLSGVETLVLDEADRMLD-MGFIED 165
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 121-285 8.54e-31

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 113.11  E-value: 8.54e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 121 SKIQEMALPmmLAHPPQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCLCLAPTYELALQTGRVVERMGKFcVDVEVM 200
Cdd:pfam00270   1 TPIQAEAIP--AILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKG-LGLKVA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 201 YAIRGNRIP--RGTDVTKQIVIGTPGTVLDWCFKRKLIDltKIRVFVLDEADVMIDtQGFSDQSIRIQSVGNKSFSSVTL 278
Cdd:pfam00270  78 SLLGGDSRKeqLEKLKGPDILVGTPGRLLDLLQERKLLK--NLKLLVLDEAHRLLD-MGFGPDLEEILRRLPKKRQILLL 154


                  ....*..
gi 1958797686 279 yaSNTIS 285
Cdd:pfam00270 155 --SATLP 159
DEXDc smart00487
DEAD-like helicases superfamily;
112-265 6.91e-28

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 106.42  E-value: 6.91e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686  112 IYAMGFNRPSKIQEMALPMMLAHPpQNLIAQSQSGTGKTAAFVLAMLSRVNAlELFPQCLCLAPTYELALQTGRVVERMG 191
Cdd:smart00487   1 IEKFGFEPLRPYQKEAIEALLSGL-RDVILAAPTGSGKTLAALLPALEALKR-GKGGRVLVLVPTRELAEQWAEELKKLG 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958797686  192 KFCvDVEVMYAIRGNRIPRGTDVTK----QIVIGTPGTVLDwCFKRKLIDLTKIRVFVLDEADVMIDtQGFSDQSIRI 265
Cdd:smart00487  79 PSL-GLKVVGLYGGDSKREQLRKLEsgktDILVTTPGRLLD-LLENDKLSLSNVDLVILDEAHRLLD-GGFGDQLEKL 153
PTZ00424 PTZ00424
helicase 45; Provisional
 111-261 6.15e-27

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 108.38  E-value: 6.15e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 111 GIYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCLCLAPTYELALQTGRVVERM 190
Cdd:PTZ00424   42 GIYSYGFEKPSAIQQRGIKPILDG--YDTIGQAQSGTGKTATFVIAALQLIDYDLNACQALILAPTRELAQQIQKVVLAL 119

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958797686 191 GKFCvDVEVMYAIRGNRIPRGTDVTKQ---IVIGTPGTVLDWCFKRKLIdLTKIRVFVLDEADVMIdTQGFSDQ 261
Cdd:PTZ00424  120 GDYL-KVRCHACVGGTVVRDDINKLKAgvhMVVGTPGRVYDMIDKRHLR-VDDLKLFILDEADEML-SRGFKGQ 190
 
Name Accession Description Interval E-value
DEADc_DDX25 cd18048
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ...
 80-266 6.79e-129

DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350806 [Multi-domain]  Cd Length: 229  Bit Score: 365.50  E-value: 6.79e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686  80 HRVEVLQKDPSSPLYSVKTFEELRLKEELLKGIYAMGFNRPSKIQEMALPMMLAHPPQNLIAQSQSGTGKTAAFVLAMLS 159
Cdd:cd18048     1 HRVEVLQRDPTSPLFSVKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADPPQNLIAQSQSGTGKTAAFVLAMLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 160 RVNALELFPQCLCLAPTYELALQTGRVVERMGKFCVDVEVMYAIRGNRIPRGTDVTKQIVIGTPGTVLDWCFKRKLIDLT 239
Cdd:cd18048    81 RVDALKLYPQCLCLSPTFELALQTGKVVEEMGKFCVGIQVIYAIRGNRPGKGTDIEAQIVIGTPGTVLDWCFKLRLIDVT 160

                         170       180
                  ....*....|....*....|....*..
gi 1958797686 240 KIRVFVLDEADVMIDTQGFSDQSIRIQ 266
Cdd:cd18048   161 NISVFVLDEADVMINVQGHSDHSVRVK 187
DEADc_DDX19_DDX25 cd17963
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ...
 111-267 2.04e-99

DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350721 [Multi-domain]  Cd Length: 196  Bit Score: 289.48  E-value: 2.04e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 111 GIYAMGFNRPSKIQEMALPMMLAHPPQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCLCLAPTYELALQTGRVVERM 190
Cdd:cd17963     8 GLYAMGFNKPSKIQETALPLILSDPPENLIAQSQSGTGKTAAFVLAMLSRVDPTLKSPQALCLAPTRELARQIGEVVEKM 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958797686 191 GKFCvDVEVMYAIRGNRIPRGTDVTKQIVIGTPGTVLDWCfKRKLIDLTKIRVFVLDEADVMIDTQGFSDQSIRIQS 267
Cdd:cd17963    88 GKFT-GVKVALAVPGNDVPRGKKITAQIVIGTPGTVLDWL-KKRQLDLKKIKILVLDEADVMLDTQGHGDQSIRIKR 162
DEADc_DDX19 cd18047
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ...
 97-266 1.16e-83

DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350805 [Multi-domain]  Cd Length: 205  Bit Score: 250.02  E-value: 1.16e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686  97 KTFEELRLKEELLKGIYAMGFNRPSKIQEMALPMMLAHPPQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCLCLAPT 176
Cdd:cd18047     1 KSFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 177 YELALQTGRVVERMGKFCVDVEVMYAIRGNRIPRGTDVTKQIVIGTPGTVLDWCFKRKLIDLTKIRVFVLDEADVMIDTQ 256
Cdd:cd18047    81 YELALQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLDEADVMIATQ 160

                         170
                  ....*....|
gi 1958797686 257 GFSDQSIRIQ 266
Cdd:cd18047   161 GHQDQSIRIQ 170
DEADc cd00268
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ...
 114-265 2.51e-43

DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350669 [Multi-domain]  Cd Length: 196  Bit Score: 146.43  E-value: 2.51e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 114 AMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALEL----FPQCLCLAPTYELALQTGRVVER 189
Cdd:cd00268     7 KLGFEKPTPIQAQAIPLILSG--RDVIGQAQTGSGKTLAFLLPILEKLLPEPKkkgrGPQALVLAPTRELAMQIAEVARK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 190 MGKFCvDVEVMyAIRGnriprGTDVTKQ---------IVIGTPGTVLDwCFKRKLIDLTKIRVFVLDEADVMIDtQGFSD 260
Cdd:cd00268    85 LGKGT-GLKVA-AIYG-----GAPIKKQiealkkgpdIVVGTPGRLLD-LIERGKLDLSNVKYLVLDEADRMLD-MGFEE 155


                  ....*
gi 1958797686 261 QSIRI 265
Cdd:cd00268   156 DVEKI 160
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
114-261 1.20e-41

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 148.37  E-value: 1.20e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 114 AMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNA-LELFPQCLCLAPTYELALQTGRVVERMGK 192
Cdd:COG0513    19 ELGYTTPTPIQAQAIPLILAG--RDVLGQAQTGTGKTAAFLLPLLQRLDPsRPRAPQALILAPTRELALQVAEELRKLAK 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958797686 193 FC-VDVEVMYairGnriprGTDVTKQ---------IVIGTPGTVLDWcFKRKLIDLTKIRVFVLDEADVMIDtQGFSDQ 261
Cdd:COG0513    97 YLgLRVATVY---G-----GVSIGRQiralkrgvdIVVATPGRLLDL-IERGALDLSGVETLVLDEADRMLD-MGFIED 165
DEADc_EIF4A cd17939
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ...
 111-265 1.01e-38

DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350697 [Multi-domain]  Cd Length: 199  Bit Score: 134.76  E-value: 1.01e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 111 GIYAMGFNRPSKIQEMA-LPMMLAHppqNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCLCLAPTYELALQTGRVVER 189
Cdd:cd17939    11 GIYAYGFEKPSAIQQRAiVPIIKGR---DVIAQAQSGTGKTATFSIGALQRIDTTVRETQALVLAPTRELAQQIQKVVKA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 190 MGKFcVDVEVMYAIRGNRIprGTDVTK-----QIVIGTPGTVLDwCFKRKLIDLTKIRVFVLDEADVMIDtQGFSDQSIR 264
Cdd:cd17939    88 LGDY-MGVKVHACIGGTSV--REDRRKlqygpHIVVGTPGRVFD-MLQRRSLRTDKIKMFVLDEADEMLS-RGFKDQIYD 162


                  .
gi 1958797686 265 I 265
Cdd:cd17939   163 I 163
DEADc_DDX6 cd17940
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ...
 111-254 3.86e-37

DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350698 [Multi-domain]  Cd Length: 201  Bit Score: 130.88  E-value: 3.86e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 111 GIYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCLCLAPTYELALQTGRVVERM 190
Cdd:cd17940    13 GIFEKGFEKPSPIQEESIPIALSG--RDILARAKNGTGKTGAYLIPILEKIDPKKDVIQALILVPTRELALQTSQVCKEL 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958797686 191 GKFCvDVEVMYAIRG-------NRIPRGTdvtkQIVIGTPGTVLDwCFKRKLIDLTKIRVFVLDEADVMID 254
Cdd:cd17940    91 GKHM-GVKVMVTTGGtslrddiMRLYQTV----HVLVGTPGRILD-LAKKGVADLSHCKTLVLDEADKLLS 155
DEADc_EIF4AII_EIF4AI_DDX2 cd18046
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ...
 111-261 8.95e-34

DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350804 [Multi-domain]  Cd Length: 201  Bit Score: 122.17  E-value: 8.95e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 111 GIYAMGFNRPSKIQEMA-LPMMLAHppqNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCLCLAPTYELALQTGRVVER 189
Cdd:cd18046    13 GIYAYGFEKPSAIQQRAiMPCIKGY---DVIAQAQSGTGKTATFSISILQQIDTSLKATQALVLAPTRELAQQIQKVVMA 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958797686 190 MGKFCvDVEVMYAIRGNRI---PRGTDVTKQIVIGTPGTVLDwCFKRKLIDLTKIRVFVLDEADVMIdTQGFSDQ 261
Cdd:cd18046    90 LGDYM-GIKCHACIGGTSVrddAQKLQAGPHIVVGTPGRVFD-MINRRYLRTDYIKMFVLDEADEML-SRGFKDQ 161
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 121-285 8.54e-31

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 113.11  E-value: 8.54e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 121 SKIQEMALPmmLAHPPQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCLCLAPTYELALQTGRVVERMGKFcVDVEVM 200
Cdd:pfam00270   1 TPIQAEAIP--AILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKG-LGLKVA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 201 YAIRGNRIP--RGTDVTKQIVIGTPGTVLDWCFKRKLIDltKIRVFVLDEADVMIDtQGFSDQSIRIQSVGNKSFSSVTL 278
Cdd:pfam00270  78 SLLGGDSRKeqLEKLKGPDILVGTPGRLLDLLQERKLLK--NLKLLVLDEAHRLLD-MGFGPDLEEILRRLPKKRQILLL 154


                  ....*..
gi 1958797686 279 yaSNTIS 285
Cdd:pfam00270 155 --SATLP 159
DEADc_DDX20 cd17943
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ...
 111-254 1.07e-30

DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350701 [Multi-domain]  Cd Length: 192  Bit Score: 113.51  E-value: 1.07e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 111 GIYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCLCLAPTYELALQTGRVVERM 190
Cdd:cd17943     4 GLKAAGFQRPSPIQLAAIPLGLAG--HDLIVQAKSGTGKTLVFVVIALESLDLERRHPQVLILAPTREIAVQIHDVFKKI 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958797686 191 GKFCVDVEVMYAIRGnrIPRGTDVTK----QIVIGTPGTVLDWCFKRKLiDLTKIRVFVLDEADVMID 254
Cdd:cd17943    82 GKKLEGLKCEVFIGG--TPVKEDKKKlkgcHIAVGTPGRIKQLIELGAL-NVSHVRLFVLDEADKLME 146
DEADc_EIF4AIII_DDX48 cd18045
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ...
 111-261 2.52e-30

DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350803 [Multi-domain]  Cd Length: 201  Bit Score: 112.95  E-value: 2.52e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 111 GIYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCLCLAPTYELALQTGRVVERM 190
Cdd:cd18045    13 GIYAYGFEKPSAIQQRAIKPIIKG--RDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILSPTRELAVQIQKVLLAL 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958797686 191 GKFcVDVEVMYAIRGNRIprGTDVTK-----QIVIGTPGTVLDwCFKRKLIDLTKIRVFVLDEADVMIdTQGFSDQ 261
Cdd:cd18045    91 GDY-MNVQCHACIGGTSV--GDDIRKldygqHIVSGTPGRVFD-MIRRRSLRTRHIKMLVLDEADEML-NKGFKEQ 161
DEXDc smart00487
DEAD-like helicases superfamily;
112-265 6.91e-28

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 106.42  E-value: 6.91e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686  112 IYAMGFNRPSKIQEMALPMMLAHPpQNLIAQSQSGTGKTAAFVLAMLSRVNAlELFPQCLCLAPTYELALQTGRVVERMG 191
Cdd:smart00487   1 IEKFGFEPLRPYQKEAIEALLSGL-RDVILAAPTGSGKTLAALLPALEALKR-GKGGRVLVLVPTRELAEQWAEELKKLG 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958797686  192 KFCvDVEVMYAIRGNRIPRGTDVTK----QIVIGTPGTVLDwCFKRKLIDLTKIRVFVLDEADVMIDtQGFSDQSIRI 265
Cdd:smart00487  79 PSL-GLKVVGLYGGDSKREQLRKLEsgktDILVTTPGRLLD-LLENDKLSLSNVDLVILDEAHRLLD-GGFGDQLEKL 153
PTZ00424 PTZ00424
helicase 45; Provisional
 111-261 6.15e-27

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 108.38  E-value: 6.15e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 111 GIYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCLCLAPTYELALQTGRVVERM 190
Cdd:PTZ00424   42 GIYSYGFEKPSAIQQRGIKPILDG--YDTIGQAQSGTGKTATFVIAALQLIDYDLNACQALILAPTRELAQQIQKVVLAL 119

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958797686 191 GKFCvDVEVMYAIRGNRIPRGTDVTKQ---IVIGTPGTVLDWCFKRKLIdLTKIRVFVLDEADVMIdTQGFSDQ 261
Cdd:PTZ00424  120 GDYL-KVRCHACVGGTVVRDDINKLKAgvhMVVGTPGRVYDMIDKRHLR-VDDLKLFILDEADEML-SRGFKGQ 190
DEADc_DDX39 cd17950
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ...
 116-255 1.05e-26

DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350708 [Multi-domain]  Cd Length: 208  Bit Score: 103.58  E-value: 1.05e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 116 GFNRPSKIQEMALPM-MLAHppqNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCLCLAPTYELALQTGRVVERMGKFC 194
Cdd:cd17950    21 GFEHPSEVQHECIPQaILGM---DVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVSVLVICHTRELAFQISNEYERFSKYM 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958797686 195 --VDVEVMY---AIRGNrIPRGTDVTKQIVIGTPGTVLDwCFKRKLIDLTKIRVFVLDEADVMIDT 255
Cdd:cd17950    98 pnVKTAVFFggvPIKKD-IEVLKNKCPHIVVGTPGRILA-LVREKKLKLSHVKHFVLDECDKMLEQ 161
DEADc_DDX3_DDX4 cd17967
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ...
 115-264 2.87e-26

DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350725 [Multi-domain]  Cd Length: 221  Bit Score: 102.95  E-value: 2.87e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 115 MGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRV--NALEL--------FPQCLCLAPTYELALQTG 184
Cdd:cd17967    18 AGYTKPTPVQKYAIPIILAG--RDLMACAQTGSGKTAAFLLPIISKLleDGPPSvgrgrrkaYPSALILAPTRELAIQIY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 185 RVVErmgKFC----VDVEVMY---AIRG--NRIPRGTDvtkqIVIGTPGTVLDWCfKRKLIDLTKIRVFVLDEADVMIDt 255
Cdd:cd17967    96 EEAR---KFSyrsgVRSVVVYggaDVVHqqLQLLRGCD----ILVATPGRLVDFI-ERGRISLSSIKFLVLDEADRMLD- 166


                  ....*....
gi 1958797686 256 QGFSDQsIR 264
Cdd:cd17967   167 MGFEPQ-IR 174
DEADc_DDX4 cd18052
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ...
 82-258 3.63e-25

DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350810 [Multi-domain]  Cd Length: 264  Bit Score: 100.81  E-value: 3.63e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686  82 VEVLQKDPSSPlysVKTFEELRLKEELLKGIYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAML--- 158
Cdd:cd18052    31 VEVTGRNPPPA---ILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAG--RDLMACAQTGSGKTAAFLLPVLtgm 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 159 -------SRVNALELfPQCLCLAPTYELALQtgrVVERMGKFCVD-----------VEVMYAIRgnRIPRGTDvtkqIVI 220
Cdd:cd18052   106 mkegltaSSFSEVQE-PQALIVAPTRELANQ---IFLEARKFSYGtcirpvvvyggVSVGHQIR--QIEKGCH----ILV 175

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1958797686 221 GTPGTVLDWcFKRKLIDLTKIRVFVLDEADVMIDtQGF 258
Cdd:cd18052   176 ATPGRLLDF-IGRGKISLSKLKYLILDEADRMLD-MGF 211
DEADc_DDX23 cd17945
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ...
 112-261 4.87e-25

DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350703 [Multi-domain]  Cd Length: 220  Bit Score: 99.70  E-value: 4.87e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 112 IYAMGFNRPSKIQEMALPMMLAhpPQNLIAQSQSGTGKTAAFVLAMLSRVNAL--------ELFPQCLCLAPTYELALQt 183
Cdd:cd17945     5 IRKLGYKEPTPIQRQAIPIGLQ--NRDIIGIAETGSGKTAAFLIPLLVYISRLppldeetkDDGPYALILAPTRELAQQ- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 184 grVVERMGKFCV--DVEVMYAIRG-------NRIPRGTDvtkqIVIGTPGTVLDwCFKRKLIDLTKIRVFVLDEADVMID 254
Cdd:cd17945    82 --IEEETQKFAKplGIRVVSIVGGhsieeqaFSLRNGCE----ILIATPGRLLD-CLERRLLVLNQCTYVVLDEADRMID 154


                  ....*..
gi 1958797686 255 tQGFSDQ 261
Cdd:cd17945   155 -MGFEPQ 160
PRK11634 PRK11634
ATP-dependent RNA helicase DeaD; Provisional
 115-253 8.02e-24

ATP-dependent RNA helicase DeaD; Provisional


Pssm-ID: 236941 [Multi-domain]  Cd Length: 629  Bit Score: 101.08  E-value: 8.02e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 115 MGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCLCLAPTYELALQTGRVVERMGKFC 194
Cdd:PRK11634   24 LGYEKPSPIQAECIPHLLNG--RDVLGMAQTGSGKTAAFSLPLLHNLDPELKAPQILVLAPTRELAVQVAEAMTDFSKHM 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958797686 195 VDVEVMYAIRGNRIP---RGTDVTKQIVIGTPGTVLDWcFKRKLIDLTKIRVFVLDEADVMI 253
Cdd:PRK11634  102 RGVNVVALYGGQRYDvqlRALRQGPQIVVGTPGRLLDH-LKRGTLDLSKLSGLVLDEADEML 162
DEADc_DDX47 cd17954
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ...
 115-254 1.64e-23

DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350712 [Multi-domain]  Cd Length: 203  Bit Score: 95.08  E-value: 1.64e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 115 MGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLsrvNALELFPQ---CLCLAPTYELALQTGRVVERMG 191
Cdd:cd17954    18 LGWKKPTKIQEEAIPVALQG--RDIIGLAETGSGKTAAFALPIL---QALLENPQrffALVLAPTRELAQQISEQFEALG 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958797686 192 KfcvDVEVMYAIrgnrIPRGTDVTKQ---------IVIGTPGTVLDWCFKRKLIDLTKIRVFVLDEADVMID 254
Cdd:cd17954    93 S---SIGLKSAV----LVGGMDMMAQaialakkphVIVATPGRLVDHLENTKGFSLKSLKFLVMDEADRLLN 157
DEADc_DDX27 cd17947
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ...
 111-261 3.30e-23

DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350705 [Multi-domain]  Cd Length: 196  Bit Score: 93.86  E-value: 3.30e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 111 GIYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVnaleLF-------PQCLCLAPTYELALQT 183
Cdd:cd17947     4 ALSSLGFTKPTPIQAAAIPLALLG--KDICASAVTGSGKTAAFLLPILERL----LYrpkkkaaTRVLVLVPTRELAMQC 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 184 GRVVERMGKFCvDVEVMYAIrGnriprGTDVTKQ---------IVIGTPGTVLDWCFKRKLIDLTKIRVFVLDEADVMID 254
Cdd:cd17947    78 FSVLQQLAQFT-DITFALAV-G-----GLSLKAQeaalrarpdIVIATPGRLIDHLRNSPSFDLDSIEILVLDEADRMLE 150


                  ....*..
gi 1958797686 255 TqGFSDQ 261
Cdd:cd17947   151 E-GFADE 156
PRK11776 PRK11776
ATP-dependent RNA helicase DbpA; Provisional
 114-260 1.39e-22

ATP-dependent RNA helicase DbpA; Provisional


Pssm-ID: 236977 [Multi-domain]  Cd Length: 460  Bit Score: 96.79  E-value: 1.39e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 114 AMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCLCLAPTYELALQTGRVVERMGKF 193
Cdd:PRK11776   21 ELGYTEMTPIQAQSLPAILAG--KDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQALVLCPTRELADQVAKEIRRLARF 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958797686 194 CVDVEVMYAIRGnrIPRGTDVTK-----QIVIGTPGTVLDWcFKRKLIDLTKIRVFVLDEADVMIDtQGFSD 260
Cdd:PRK11776   99 IPNIKVLTLCGG--VPMGPQIDSlehgaHIIVGTPGRILDH-LRKGTLDLDALNTLVLDEADRMLD-MGFQD 166
DEADc_MSS116 cd17964
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ...
 111-265 1.51e-22

DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350722 [Multi-domain]  Cd Length: 211  Bit Score: 92.65  E-value: 1.51e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 111 GIYAMGFNRPSKIQEMALPMMLAhPPQNLIAQSQSGTGKTAAFVLAMLSRVnaLELFPQ-------CLCLAPTYELALQT 183
Cdd:cd17964     8 ALTRMGFETMTPVQQKTLKPILS-TGDDVLARAKTGTGKTLAFLLPAIQSL--LNTKPAgrrsgvsALIISPTRELALQI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 184 GRVVERMGKFCVDVEVMYAIRGNRIP----RGTDVTKQIVIGTPGTVLDWCFK-RKLIDLTKIRVFVLDEADVMIDtQGF 258
Cdd:cd17964    85 AAEAKKLLQGLRKLRVQSAVGGTSRRaelnRLRRGRPDILVATPGRLIDHLENpGVAKAFTDLDYLVLDEADRLLD-MGF 163


                  ....*..
gi 1958797686 259 SDQSIRI 265
Cdd:cd17964   164 RPDLEQI 170
DEADc_DDX54 cd17959
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ...
 111-261 2.13e-22

DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350717 [Multi-domain]  Cd Length: 205  Bit Score: 91.98  E-value: 2.13e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 111 GIYAMGFNRPSKIQEMALPMMLAhpPQNLIAQSQSGTGKTAAFVLAMLSRVNALElfPQ----CLCLAPTYELALQTGRV 186
Cdd:cd17959    15 AIKKKGYKVPTPIQRKTIPLILD--GRDVVAMARTGSGKTAAFLIPMIEKLKAHS--PTvgarALILSPTRELALQTLKV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 187 VERMGKFcVDVEVMYAIRGNR-------IPRGTDvtkqIVIGTPGTVLDWCFKRKLiDLTKIRVFVLDEADVMIDtQGFS 259
Cdd:cd17959    91 TKELGKF-TDLRTALLVGGDSleeqfeaLASNPD----IIIATPGRLLHLLVEMNL-KLSSVEYVVFDEADRLFE-MGFA 163


                  ..
gi 1958797686 260 DQ 261
Cdd:cd17959   164 EQ 165
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
 115-285 2.44e-22

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 92.26  E-value: 2.44e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 115 MGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELF------PQCLCLAPTYELALQTGRVVE 188
Cdd:cd17949     9 MGIEKPTAIQKLAIPVLLQG--RDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRvdrsdgTLALVLVPTRELALQIYEVLE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 189 RMGKFCVDVEVMYAIRGN-------RIPRGtdVTkqIVIGTPGTVLDWCFKRKLIDLTKIRVFVLDEADVMIDtQGF--- 258
Cdd:cd17949    87 KLLKPFHWIVPGYLIGGEkrksekaRLRKG--VN--ILIATPGRLLDHLKNTQSFDVSNLRWLVLDEADRLLD-MGFekd 161

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1958797686 259 --------SDQSIRIQSVGNKSFSSVTLYASNTIS 285
Cdd:cd17949   162 itkilellDDKRSKAGGEKSKPSRRQTVLVSATLT 196
DEADc_DDX5_DDX17 cd17966
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ...
 112-264 5.89e-21

DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350724 [Multi-domain]  Cd Length: 197  Bit Score: 88.20  E-value: 5.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 112 IYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELF-----PQCLCLAPTYELALQtgrV 186
Cdd:cd17966     5 LKRQGFTEPTAIQAQGWPMALSG--RDMVGIAQTGSGKTLAFLLPAIVHINAQPPLergdgPIVLVLAPTRELAQQ---I 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 187 VERMGKFCVDVEV-MYAIRGNrIPRGTDVTK-----QIVIGTPGTVLDWCFKRKlIDLTKIRVFVLDEADVMIDtQGFSD 260
Cdd:cd17966    80 QQEANKFGGSSRLrNTCVYGG-APKGPQIRDlrrgvEICIATPGRLIDFLDQGK-TNLRRVTYLVLDEADRMLD-MGFEP 156


                  ....
gi 1958797686 261 QsIR 264
Cdd:cd17966   157 Q-IR 159
DEADc_DDX1 cd17938
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ...
 115-265 9.18e-20

DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350696 [Multi-domain]  Cd Length: 204  Bit Score: 85.07  E-value: 9.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 115 MGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVnalelfpQCLCLAPTYELALQTGRVVERMGKFC 194
Cdd:cd17938    17 LDWLLPTDIQAEAIPLILGG--GDVLMAAETGSGKTGAFCLPVLQIV-------VALILEPSRELAEQTYNCIENFKKYL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 195 VD--VEVMYAIRG-------NRIPRGTDvtkqIVIGTPGTVLDWcFKRKLIDLTKIRVFVLDEADVMIDtQGFSDQSIRI 265
Cdd:cd17938    88 DNpkLRVALLIGGvkareqlKRLESGVD----IVVGTPGRLEDL-IKTGKLDLSSVRFFVLDEADRLLS-QGNLETINRI 161
DEADc_DDX55 cd17960
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ...
 111-265 9.83e-20

DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350718 [Multi-domain]  Cd Length: 202  Bit Score: 84.94  E-value: 9.83e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 111 GIYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQ-----CLCLAPTYELALQTGR 185
Cdd:cd17960     4 VVAELGFTSMTPVQAATIPLFLSN--KDVVVEAVTGSGKTLAFLIPVLEILLKRKANLKkgqvgALIISPTRELATQIYE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 186 VVERMGKFCVD-VEVMYAIRGNRIprGTDVTK------QIVIGTPGTVLDWcFKRK--LIDLTKIRVFVLDEADVMIDTq 256
Cdd:cd17960    82 VLQSFLEHHLPkLKCQLLIGGTNV--EEDVKKfkrngpNILVGTPGRLEEL-LSRKadKVKVKSLEVLVLDEADRLLDL- 157


                  ....*....
gi 1958797686 257 GFSDQSIRI 265
Cdd:cd17960   158 GFEADLNRI 166
DEADc_DDX59 cd17962
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ...
 112-286 1.09e-19

DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350720 [Multi-domain]  Cd Length: 193  Bit Score: 84.52  E-value: 1.09e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 112 IYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCLCLAPTYELALQTGRVVERMG 191
Cdd:cd17962     5 LKKAGYEVPTPIQMQMIPVGLLG--RDILASADTGSGKTAAFLLPVIIRCLTEHRNPSALILTPTRELAVQIEDQAKELM 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 192 KFCVDVEVMYAIRGNRIPRGTDVTKQ---IVIGTPGTVLDwCFKRKLIDLTKIRVFVLDEADVMIDtQGFSDQSIRIqsV 268
Cdd:cd17962    83 KGLPPMKTALLVGGLPLPPQLYRLQQgvkVIIATPGRLLD-ILKQSSVELDNIKIVVVDEADTMLK-MGFQQQVLDI--L 158

                         170
                  ....*....|....*...
gi 1958797686 269 GNKSFSSVTLYASNTISF 286
Cdd:cd17962   159 ENISHDHQTILVSATIPR 176
PRK04537 PRK04537
ATP-dependent RNA helicase RhlB; Provisional
 92-258 3.03e-19

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235307 [Multi-domain]  Cd Length: 572  Bit Score: 87.31  E-value: 3.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686  92 PLYSVkTFEELRLKEELLKGIYAMGFNRPSKIQEMALPMMLahPPQNLIAQSQSGTGKTAAFVLAMLSR-------VNAL 164
Cdd:PRK04537    5 PLTDL-TFSSFDLHPALLAGLESAGFTRCTPIQALTLPVAL--PGGDVAGQAQTGTGKTLAFLVAVMNRllsrpalADRK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 165 ELFPQCLCLAPTYELALQtgrVVERMGKFCVDVEVMYAIrgnrIPRGTDVTKQ---------IVIGTPGTVLDWCFKRKL 235
Cdd:PRK04537   82 PEDPRALILAPTRELAIQ---IHKDAVKFGADLGLRFAL----VYGGVDYDKQrellqqgvdVIIATPGRLIDYVKQHKV 154

                         170       180
                  ....*....|....*....|...
gi 1958797686 236 IDLTKIRVFVLDEADVMIDTqGF 258
Cdd:PRK04537  155 VSLHACEICVLDEADRMFDL-GF 176
DEADc_DDX56 cd17961
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ...
 111-260 3.71e-19

DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350719 [Multi-domain]  Cd Length: 206  Bit Score: 83.40  E-value: 3.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 111 GIYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRV------NALELFPQCLCLAPTYELALQTG 184
Cdd:cd17961     8 AIAKLGWEKPTLIQSKAIPLALEG--KDILARARTGSGKTAAYALPIIQKIlkakaeSGEEQGTRALILVPTRELAQQVS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 185 RVVERMGKFC-VDVEVMyAIRGNriprGTDVTKQ--------IVIGTPGTVLDWCFKRKLIDLTKIRVFVLDEADVMIdT 255
Cdd:cd17961    86 KVLEQLTAYCrKDVRVV-NLSAS----SSDSVQRallaekpdIVVSTPARLLSHLESGSLLLLSTLKYLVIDEADLVL-S 159


                  ....*
gi 1958797686 256 QGFSD 260
Cdd:cd17961   160 YGYEE 164
DEADc_DDX3 cd18051
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ...
 117-265 6.56e-19

DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350809 [Multi-domain]  Cd Length: 249  Bit Score: 83.55  E-value: 6.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 117 FNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRV----------------NALELFPQCLCLAPTYELA 180
Cdd:cd18051    41 YTKPTPVQKHAIPIIKSK--RDLMACAQTGSGKTAAFLLPILSQIyeqgpgeslpsesgyyGRRKQYPLALVLAPTRELA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 181 LQtgrVVERMGKF----CVDVEVMYAirgnriprGTDVTKQI---------VIGTPGTVLDWcFKRKLIDLTKIRVFVLD 247
Cdd:cd18051   119 SQ---IYDEARKFayrsRVRPCVVYG--------GADIGQQMrdlergchlLVATPGRLVDM-LERGKIGLDYCKYLVLD 186

                         170
                  ....*....|....*...
gi 1958797686 248 EADVMIDtQGFSDQSIRI 265
Cdd:cd18051   187 EADRMLD-MGFEPQIRRI 203
PRK10590 PRK10590
ATP-dependent RNA helicase RhlE; Provisional
 116-258 1.26e-18

ATP-dependent RNA helicase RhlE; Provisional


Pssm-ID: 236722 [Multi-domain]  Cd Length: 456  Bit Score: 85.24  E-value: 1.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 116 GFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQ------CLCLAPTYELALQTGRVVER 189
Cdd:PRK10590   20 GYREPTPIQQQAIPAVLEG--RDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKgrrpvrALILTPTRELAAQIGENVRD 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958797686 190 MGKFcVDVEVMYAIRGNRI-PR------GTDVtkqiVIGTPGTVLDWCFKRKLiDLTKIRVFVLDEADVMIDtQGF 258
Cdd:PRK10590   98 YSKY-LNIRSLVVFGGVSInPQmmklrgGVDV----LVATPGRLLDLEHQNAV-KLDQVEILVLDEADRMLD-MGF 166
DEADc_DDX52 cd17957
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ...
 116-261 2.84e-18

DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350715 [Multi-domain]  Cd Length: 198  Bit Score: 80.71  E-value: 2.84e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 116 GFNRPSKIQEMALPMMLAHPpqNLIAQSQSGTGKTAAFVLAMLSRVNAL--ELFPQCLCLAPTYELALQTGRVVERMGKF 193
Cdd:cd17957     9 GYREPTPIQMQAIPILLHGR--DLLACAPTGSGKTLAFLIPILQKLGKPrkKKGLRALILAPTRELASQIYRELLKLSKG 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958797686 194 C-VDVEVMYaiRGNR-IPRGTDVTKQ---IVIGTPGTVLDwCFKRKLIDLTKIRVFVLDEADVMIDTqGFSDQ 261
Cdd:cd17957    87 TgLRIVLLS--KSLEaKAKDGPKSITkydILVSTPLRLVF-LLKQGPIDLSSVEYLVLDEADKLFEP-GFREQ 155
PRK04837 PRK04837
ATP-dependent RNA helicase RhlB; Provisional
 111-258 4.12e-18

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235314 [Multi-domain]  Cd Length: 423  Bit Score: 83.48  E-value: 4.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 111 GIYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLA----MLS-------RVNAlelfPQCLCLAPTYEL 179
Cdd:PRK04837   22 ALEKKGFHNCTPIQALALPLTLAG--RDVAGQAQTGTGKTMAFLTAtfhyLLShpapedrKVNQ----PRALIMAPTREL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 180 ALQTGRVVERMGKFC-VDVEVMYAIRG-----NRIPRGTDvtkqIVIGTPGTVLDWcFKRKLIDLTKIRVFVLDEADVMI 253
Cdd:PRK04837   96 AVQIHADAEPLAQATgLKLGLAYGGDGydkqlKVLESGVD----ILIGTTGRLIDY-AKQNHINLGAIQVVVLDEADRMF 170


                  ....*
gi 1958797686 254 DTqGF 258
Cdd:PRK04837  171 DL-GF 174
DEADc_DDX49 cd17955
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ...
 114-256 3.81e-17

DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350713 [Multi-domain]  Cd Length: 204  Bit Score: 78.04  E-value: 3.81e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 114 AMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCLCLAPTYELALQTGRVVERMGKF 193
Cdd:cd17955    16 SLGIKEPTPIQKLCIPEILAG--RDVIGGAKTGSGKTAAFALPILQRLSEDPYGIFALVLTPTRELAYQIAEQFRALGAP 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 194 CVdvevmyaIRGNRIPRGTDVTKQ---------IVIGTPGTVLD---------WCFKRklidltkIRVFVLDEADVMIDT 255
Cdd:cd17955    94 LG-------LRCCVIVGGMDMVKQalelskrphIVVATPGRLADhlrssddttKVLSR-------VKFLVLDEADRLLTG 159


                  .
gi 1958797686 256 Q 256
Cdd:cd17955   160 S 160
DEADc_DDX21_DDX50 cd17944
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ...
 137-272 9.15e-17

DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350702 [Multi-domain]  Cd Length: 202  Bit Score: 76.81  E-value: 9.15e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 137 QNLIAQSQSGTGKTAAFVLAMLSRVNALE------LFPQCLCLAPTYELALQTGR----VVERMGKFCVDVEVMYAIRGN 206
Cdd:cd17944    28 KDLIAQARTGTGKTFSFAIPLIEKLQEDQqprkrgRAPKVLVLAPTRELANQVTKdfkdITRKLSVACFYGGTPYQQQIF 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958797686 207 RIPRGTDvtkqIVIGTPGTVLDWCFKRKLiDLTKIRVFVLDEADVMIDtQGFSDQSIRIQSVGNKS 272
Cdd:cd17944   108 AIRNGID----ILVGTPGRIKDHLQNGRL-DLTKLKHVVLDEVDQMLD-MGFAEQVEEILSVSYKK 167
DEADc_DDX43_DDX53 cd17958
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ...
 112-265 1.74e-16

DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350716 [Multi-domain]  Cd Length: 197  Bit Score: 75.96  E-value: 1.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 112 IYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVL-AMLSRVNALELF-----PQCLCLAPTYELALQTGR 185
Cdd:cd17958     5 IKKQGFEKPSPIQSQAWPIILQG--IDLIGVAQTGTGKTLAYLLpGFIHLDLQPIPReqrngPGVLVLTPTRELALQIEA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 186 VVERMGKFCVDVEVMYAiRGNRIPRGTDVTK--QIVIGTPGTVLDWCFKrKLIDLTKIRVFVLDEADVMIDtQGFSDQSI 263
Cdd:cd17958    83 ECSKYSYKGLKSVCVYG-GGNRNEQIEDLSKgvDIIIATPGRLNDLQMN-NVINLKSITYLVLDEADRMLD-MGFEPQIR 159


                  ..
gi 1958797686 264 RI 265
Cdd:cd17958   160 KI 161
PRK11192 PRK11192
ATP-dependent RNA helicase SrmB; Provisional
 114-286 2.32e-16

ATP-dependent RNA helicase SrmB; Provisional


Pssm-ID: 236877 [Multi-domain]  Cd Length: 434  Bit Score: 78.45  E-value: 2.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 114 AMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRvnaLELFPQ-------CLCLAPTYELALQTGRV 186
Cdd:PRK11192   18 DKGYTRPTAIQAEAIPPALDG--RDVLGSAPTGTGKTAAFLLPALQH---LLDFPRrksgpprILILTPTRELAMQVADQ 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 187 VERMGKFC-VDVEVmyaIRGNrIPRGT--DV---TKQIVIGTPGTVLDWcFKRKLIDLTKIRVFVLDEADVMIDtQGFSD 260
Cdd:PRK11192   93 ARELAKHThLDIAT---ITGG-VAYMNhaEVfseNQDIVVATPGRLLQY-IKEENFDCRAVETLILDEADRMLD-MGFAQ 166

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1958797686 261 --QSIRIQSVGNKS---FSSvTLYASNTISF 286
Cdd:PRK11192  167 diETIAAETRWRKQtllFSA-TLEGDAVQDF 196
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 112-265 3.42e-16

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 78.42  E-value: 3.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 112 IYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNAL----ELF---PQCLCLAPTYELALQTG 184
Cdd:PRK01297  102 IHDLGFPYCTPIQAQVLGYTLAG--HDAIGRAQTGTGKTAAFLISIINQLLQTpppkERYmgePRALIIAPTRELVVQIA 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 185 RVVERMGKFcVDVEVMYAIrgnripRGTDVTKQ----------IVIGTPGTVLDWCfKRKLIDLTKIRVFVLDEADVMID 254
Cdd:PRK01297  180 KDAAALTKY-TGLNVMTFV------GGMDFDKQlkqlearfcdILVATPGRLLDFN-QRGEVHLDMVEVMVLDEADRMLD 251

                         170
                  ....*....|.
gi 1958797686 255 tQGFSDQSIRI 265
Cdd:PRK01297  252 -MGFIPQVRQI 261
PLN00206 PLN00206
DEAD-box ATP-dependent RNA helicase; Provisional
 112-265 4.61e-16

DEAD-box ATP-dependent RNA helicase; Provisional


Pssm-ID: 215103 [Multi-domain]  Cd Length: 518  Bit Score: 77.91  E-value: 4.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 112 IYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELF-------PQCLCLAPTYELALQTG 184
Cdd:PLN00206  136 LETAGYEFPTPIQMQAIPAALSG--RSLLVSADTGSGKTASFLVPIISRCCTIRSGhpseqrnPLAMVLTPTRELCVQVE 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 185 RVVERMGKfCVDVEVMYAIRGNRIPRGTDVTKQ---IVIGTPGTVLDWCFKRKlIDLTKIRVFVLDEADVMIDtQGFSDQ 261
Cdd:PLN00206  214 DQAKVLGK-GLPFKTALVVGGDAMPQQLYRIQQgveLIVGTPGRLIDLLSKHD-IELDNVSVLVLDEVDCMLE-RGFRDQ 290


                  ....
gi 1958797686 262 SIRI 265
Cdd:PLN00206  291 VMQI 294
DEADc_DDX42 cd17952
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ...
 112-261 7.40e-16

DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350710 [Multi-domain]  Cd Length: 197  Bit Score: 74.37  E-value: 7.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 112 IYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRV-NALELFPQ----CLCLAPTYELALQTGRV 186
Cdd:cd17952     5 IRKQEYEQPTPIQAQALPVALSG--RDMIGIAKTGSGKTAAFIWPMLVHImDQRELEKGegpiAVIVAPTRELAQQIYLE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 187 VERMGK-FCVDVEVMYAIRG-----NRIPRGTDvtkqIVIGTPGTVLDwCFKRKLIDLTKIRVFVLDEADVMIDTqGFSD 260
Cdd:cd17952    83 AKKFGKaYNLRVVAVYGGGSkweqaKALQEGAE----IVVATPGRLID-MVKKKATNLQRVTYLVLDEADRMFDM-GFEY 156


                  .
gi 1958797686 261 Q 261
Cdd:cd17952   157 Q 157
DEADc_DDX46 cd17953
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ...
 112-265 1.54e-15

DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350711 [Multi-domain]  Cd Length: 222  Bit Score: 73.95  E-value: 1.54e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 112 IYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELF-----PQCLCLAPTYELALQTGRV 186
Cdd:cd17953    27 IKKLGYEKPTPIQAQALPAIMSG--RDVIGIAKTGSGKTLAFLLPMFRHIKDQRPVkpgegPIGLIMAPTRELALQIYVE 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 187 VERMGKfCVDVEVMYAIRGNRIP-------RGTDvtkqIVIGTPGTVLDW--CFKRKLIDLTKIRVFVLDEADVMIDtQG 257
Cdd:cd17953   105 CKKFSK-ALGLRVVCVYGGSGISeqiaelkRGAE----IVVCTPGRMIDIltANNGRVTNLRRVTYVVLDEADRMFD-MG 178


                  ....*...
gi 1958797686 258 FSDQSIRI 265
Cdd:cd17953   179 FEPQIMKI 186
DEADc_DDX10 cd17941
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ...
 116-261 1.07e-14

DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350699 [Multi-domain]  Cd Length: 198  Bit Score: 71.17  E-value: 1.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 116 GFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQ----CLCLAPTYELALQTGRVVERMG 191
Cdd:cd17941     9 GFIKMTEIQRDSIPHALQG--RDILGAAKTGSGKTLAFLVPLLEKLYRERWTPEdglgALIISPTRELAMQIFEVLRKVG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 192 KFcvdvEVMYA--IRGnriprGTDV--------TKQIVIGTPGTVLDWCFKRKLIDLTKIRVFVLDEADVMIDTqGFSDQ 261
Cdd:cd17941    87 KY----HSFSAglIIG-----GKDVkeekerinRMNILVCTPGRLLQHMDETPGFDTSNLQMLVLDEADRILDM-GFKET 156
DEADc_DDX5 cd18049
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ...
 117-265 1.13e-14

DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350807 [Multi-domain]  Cd Length: 234  Bit Score: 71.58  E-value: 1.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 117 FNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELF-----PQCLCLAPTYELALQTGRVVERMG 191
Cdd:cd18049    44 FTEPTAIQAQGWPVALSG--LDMVGVAQTGSGKTLSYLLPAIVHINHQPFLergdgPICLVLAPTRELAQQVQQVAAEYG 121

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958797686 192 KFC-VDVEVMY--AIRGNRIpRGTDVTKQIVIGTPGTVLDWCFKRKlIDLTKIRVFVLDEADVMIDtQGFSDQSIRI 265
Cdd:cd18049   122 RACrLKSTCIYggAPKGPQI-RDLERGVEICIATPGRLIDFLEAGK-TNLRRCTYLVLDEADRMLD-MGFEPQIRKI 195
DEADc_DDX24 cd17946
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ...
 111-260 1.36e-14

DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350704 [Multi-domain]  Cd Length: 235  Bit Score: 71.50  E-value: 1.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 111 GIYAMGFNRPSKIQEMALPMMLaHPPQNLIAQSQSGTGKTAAF-------VLAMLSRVNALELF--PQCLCLAPTYELAL 181
Cdd:cd17946     4 ALADLGFSEPTPIQALALPAAI-RDGKDVIGAAETGSGKTLAFgipilerLLSQKSSNGVGGKQkpLRALILTPTRELAV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 182 QTGRVVERMGKFcVDVEVMyAIRGnriprGTDVTKQ---------IVIGTPGTVLDwcfkrkLID--------LTKIRVF 244
Cdd:cd17946    83 QVKDHLKAIAKY-TNIKIA-SIVG-----GLAVQKQerllkkrpeIVVATPGRLWE------LIQegnehlanLKSLRFL 149

                         170
                  ....*....|....*.
gi 1958797686 245 VLDEADVMIDTQGFSD 260
Cdd:cd17946   150 VLDEADRMLEKGHFAE 165
DEADc_DDX41 cd17951
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ...
 111-260 1.62e-14

DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350709 [Multi-domain]  Cd Length: 206  Bit Score: 70.83  E-value: 1.62e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 111 GIYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLsrVNALEL----------FPQCLCLAPTYELA 180
Cdd:cd17951     4 GLKKKGIKKPTPIQMQGLPTILSG--RDMIGIAFTGSGKTLVFTLPLI--MFALEQekklpfikgeGPYGLIVCPSRELA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 181 LQTGRVVERMGKFCVD-----VEVMYAIRGNRIPRGTDVTKQ---IVIGTPGTVLDWCFKRKlIDLTKIRVFVLDEADVM 252
Cdd:cd17951    80 RQTHEVIEYYCKALQEggypqLRCLLCIGGMSVKEQLEVIRKgvhIVVATPGRLMDMLNKKK-INLDICRYLCLDEADRM 158


                  ....*...
gi 1958797686 253 IDtQGFSD 260
Cdd:cd17951   159 ID-MGFEE 165
DEADc_DDX17 cd18050
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ...
 117-265 2.28e-14

DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350808 [Multi-domain]  Cd Length: 271  Bit Score: 71.58  E-value: 2.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 117 FNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELF-----PQCLCLAPTYELALQTGRVVERMG 191
Cdd:cd18050    82 FKEPTPIQCQGFPLALSG--RDMVGIAQTGSGKTLAYLLPAIVHINHQPYLergdgPICLVLAPTRELAQQVQQVADDYG 159

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958797686 192 KFC-VDVEVMY--AIRGNRIpRGTDVTKQIVIGTPGTVLDWCFKRKlIDLTKIRVFVLDEADVMIDtQGFSDQSIRI 265
Cdd:cd18050   160 KSSrLKSTCIYggAPKGPQI-RDLERGVEICIATPGRLIDFLEAGK-TNLRRCTYLVLDEADRMLD-MGFEPQIRKI 233
PTZ00110 PTZ00110
helicase; Provisional
 112-264 8.79e-13

helicase; Provisional


Pssm-ID: 240273 [Multi-domain]  Cd Length: 545  Bit Score: 68.26  E-value: 8.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 112 IYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELF-----PQCLCLAPTYELALQtgrV 186
Cdd:PTZ00110  145 LKNAGFTEPTPIQVQGWPIALSG--RDMIGIAETGSGKTLAFLLPAIVHINAQPLLrygdgPIVLVLAPTRELAEQ---I 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 187 VERMGKFCVDVEV--------------MYAIRgnripRGTdvtkQIVIGTPGTVLDWcFKRKLIDLTKIRVFVLDEADVM 252
Cdd:PTZ00110  220 REQCNKFGASSKIrntvayggvpkrgqIYALR-----RGV----EILIACPGRLIDF-LESNVTNLRRVTYLVLDEADRM 289

                         170
                  ....*....|..
gi 1958797686 253 IDtQGFSDQsIR 264
Cdd:PTZ00110  290 LD-MGFEPQ-IR 299
DEADc_DDX18 cd17942
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ...
 111-261 4.56e-12

DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350700 [Multi-domain]  Cd Length: 198  Bit Score: 63.53  E-value: 4.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 111 GIYAMGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQ----CLCLAPTYELALQTgrv 186
Cdd:cd17942     4 AIEEMGFTKMTEIQAKSIPPLLEG--RDVLGAAKTGSGKTLAFLIPAIELLYKLKFKPRngtgVIIISPTRELALQI--- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 187 vermgkFCVDVEVM------YAIRGNRIPRGTDVTK-----QIVIGTPGTVLD-------WCFKrklidltKIRVFVLDE 248
Cdd:cd17942    79 ------YGVAKELLkyhsqtFGIVIGGANRKAEAEKlgkgvNILVATPGRLLDhlqntkgFLYK-------NLQCLIIDE 145

                         170
                  ....*....|...
gi 1958797686 249 ADVMIDtQGFSDQ 261
Cdd:cd17942   146 ADRILE-IGFEEE 157
DEADc_DDX28 cd17948
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ...
 115-254 8.10e-11

DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350706 [Multi-domain]  Cd Length: 231  Bit Score: 60.84  E-value: 8.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 115 MGFNRPSKIQEMALPMMLAHppQNLIAQSQSGTGKTAAFVLAMLSRVNALELF-------PQCLCLAPTYELALQTGRVV 187
Cdd:cd17948     8 QGITKPTTVQKQGIPSILRG--RNTLCAAETGSGKTLTYLLPIIQRLLRYKLLaegpfnaPRGLVITPSRELAEQIGSVA 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958797686 188 ERMGK-FCVDVEVMYAIRGNR-IPRGTDVTKQIVIGTPGtVLDWCFKRKLIDLTKIRVFVLDEADVMID 254
Cdd:cd17948    86 QSLTEgLGLKVKVITGGRTKRqIRNPHFEEVDILVATPG-ALSKLLTSRIYSLEQLRHLVLDEADTLLD 153
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 138-266 3.01e-10

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 57.41  E-value: 3.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 138 NLIAQSQSGTGKTAAFVLAMLSRvnALELFPQCLCLAPTYELALQTGRVVERMGKFCVDVEVMYA------IRGNRIPRg 211
Cdd:cd00046     3 NVLITAPTGSGKTLAALLAALLL--LLKKGKKVLVLVPTKALALQTAERLRELFGPGIRVAVLVGgssaeeREKNKLGD- 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958797686 212 tdvtKQIVIGTPGTVLDWCFKRKLIDLTKIRVFVLDEADvMIDTQGFSDQSIRIQ 266
Cdd:cd00046    80 ----ADIIIATPDMLLNLLLREDRLFLKDLKLIIVDEAH-ALLIDSRGALILDLA 129
DEADc_DDX51 cd17956
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ...
 114-254 1.16e-07

DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350714 [Multi-domain]  Cd Length: 231  Bit Score: 51.48  E-value: 1.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 114 AMGFNRPSKIQEMALPMMLA-------HPPQNLIAQSQSGTGKTAAFVL----AMLSRVNAlELfpQCLCLAPTYELALQ 182
Cdd:cd17956     7 NNGITSAFPVQAAVIPWLLPsskstppYRPGDLCVSAPTGSGKTLAYVLpivqALSKRVVP-RL--RALIVVPTKELVQQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 183 TGRVVERMGKfCVDVEVMyAIRGNR--------IPRGT----DVTKQIVIGTPGTVLDWCFKRKLIDLTKIRVFVLDEAD 250
Cdd:cd17956    84 VYKVFESLCK-GTGLKVV-SLSGQKsfkkeqklLLVDTsgryLSRVDILVATPGRLVDHLNSTPGFTLKHLRFLVIDEAD 161


                  ....
gi 1958797686 251 VMID 254
Cdd:cd17956   162 RLLN 165
DEADc_MRH4 cd17965
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ...
 120-255 4.48e-07

DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350723 [Multi-domain]  Cd Length: 251  Bit Score: 50.07  E-value: 4.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 120 PSKIQEMALPMMLAHPPQN---------------LIAqSQSGTGKTAAFVLAMLSRVNALELF----------------- 167
Cdd:cd17965    31 PSPIQTLAIKKLLKTLMRKvtkqtsneepklevfLLA-AETGSGKTLAYLAPLLDYLKRQEQEpfeeaeeeyesakdtgr 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 168 PQCLCLAPTYELALQTGRVVERM--------GKFCVDVEVMYAIRGNRIPRGTDvtkqIVIGTPGTVLDWCFKRKLIdLT 239
Cdd:cd17965   110 PRSVILVPTHELVEQVYSVLKKLshtvklgiKTFSSGFGPSYQRLQLAFKGRID----ILVTTPGKLASLAKSRPKI-LS 184

                         170
                  ....*....|....*.
gi 1958797686 240 KIRVFVLDEADVMIDT 255
Cdd:cd17965   185 RVTHLVVDEADTLFDR 200
DEXHc_dicer cd18034
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ...
 137-249 2.31e-03

DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350792 [Multi-domain]  Cd Length: 200  Bit Score: 38.40  E-value: 2.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797686 137 QNLIAQSQSGTGKT--AAFVLAMLSRVNALELFPQCLC--LAPTYELALQTGRVVE-----RMGKFCVDVEVMYAIRG-- 205
Cdd:cd18034    17 RNTIVVLPTGSGKTliAVMLIKEMGELNRKEKNPKKRAvfLVPTVPLVAQQAEAIRshtdlKVGEYSGEMGVDKWTKErw 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1958797686 206 NRIPRGTDVtkqiVIGTPGTVLDWcFKRKLIDLTKIRVFVLDEA 249
Cdd:cd18034    97 KEELEKYDV----LVMTAQILLDA-LRHGFLSLSDINLLIFDEC 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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