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Conserved domains on  [gi|1958797261|ref|XP_038937793|]
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alpha-1,2-mannosyltransferase ALG9 isoform X1 [Rattus norvegicus]

Protein Classification

glycosyltransferase family protein( domain architecture ID 229536)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 51-377 4.32e-87

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member pfam03901:

Pssm-ID: 473917  Cd Length: 414  Bit Score: 273.86  E-value: 4.32e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797261  51 KLTRAVCKKFGLHVSRMMLAFLVLSTGMFCSSSAFLPSSFCMYTTLVAMTGW--------YMDKTPIAVLGVAAGAILGW 122
Cdd:pfam03901  97 YLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLleygntsvSNYKYLKAVLLIAALAILGR 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797261 123 PFSAALGLPIAFDLL--AMKHRWKSFF--LWSLAALVLFLVPVVVI--DSYYYGKLVIAPLNIVLYNVFtSHGPDLYGTE 196
Cdd:pfam03901 177 PTSALLWLPLVLYLLlrLRGKRLKLFLflAISLGLLVALLVLGAVIliDSYFYGRFVFTPLNFLKYNVL-SNGSSFYGTH 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797261 197 PWYFYLINGFLNFNVAFALALLVLPLTFLMEYLLQrfhvqnlghpYWLTLAPMYIWFMIFFIQPHKEERFLFPVYPLICL 276
Cdd:pfam03901 256 PWYFYFSNGLPNILGPFLLAFILGPLVLLLRKVSR----------LSQLLAPILIWLFIYSLQPHKEERFLYPVYPLILL 325

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797261 277 CGAVALSALQkcyhfvfQRYRLEHYTVTSSWLalgtvFLFGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIHTVPEG 356
Cdd:pfam03901 326 SAAIALTRLS-------RRSWKVRKKLSLLFL-----LLFFNVSLARLFGLVHQYGAPLAVYDVMSFLNETPRENRNPAG 393

                         330       340
                  ....*....|....*....|.
gi 1958797261 357 RPVNVCVGKEWYRFPSSFLLP 377
Cdd:pfam03901 394 PPVNVCIGMECYSTPSSFFLH 414
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 51-377 4.32e-87

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 273.86  E-value: 4.32e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797261  51 KLTRAVCKKFGLHVSRMMLAFLVLSTGMFCSSSAFLPSSFCMYTTLVAMTGW--------YMDKTPIAVLGVAAGAILGW 122
Cdd:pfam03901  97 YLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLleygntsvSNYKYLKAVLLIAALAILGR 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797261 123 PFSAALGLPIAFDLL--AMKHRWKSFF--LWSLAALVLFLVPVVVI--DSYYYGKLVIAPLNIVLYNVFtSHGPDLYGTE 196
Cdd:pfam03901 177 PTSALLWLPLVLYLLlrLRGKRLKLFLflAISLGLLVALLVLGAVIliDSYFYGRFVFTPLNFLKYNVL-SNGSSFYGTH 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797261 197 PWYFYLINGFLNFNVAFALALLVLPLTFLMEYLLQrfhvqnlghpYWLTLAPMYIWFMIFFIQPHKEERFLFPVYPLICL 276
Cdd:pfam03901 256 PWYFYFSNGLPNILGPFLLAFILGPLVLLLRKVSR----------LSQLLAPILIWLFIYSLQPHKEERFLYPVYPLILL 325

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797261 277 CGAVALSALQkcyhfvfQRYRLEHYTVTSSWLalgtvFLFGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIHTVPEG 356
Cdd:pfam03901 326 SAAIALTRLS-------RRSWKVRKKLSLLFL-----LLFFNVSLARLFGLVHQYGAPLAVYDVMSFLNETPRENRNPAG 393

                         330       340
                  ....*....|....*....|.
gi 1958797261 357 RPVNVCVGKEWYRFPSSFLLP 377
Cdd:pfam03901 394 PPVNVCIGMECYSTPSSFFLH 414
PLN02816 PLN02816
mannosyltransferase
 164-286 3.65e-08

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 55.81  E-value: 3.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797261 164 IDSYYYGKLVIAPLNIVLYNvFTSHGPDLYGTEPWYFYLINGFLnfnvafalallvlpltfLMEYLLQRFHVQNLGHPYW 243
Cdd:PLN02816  257 LDRLMYGSWVIVPLNFLKFN-FLSSGGDYYGTHPWHWYFTQGFL-----------------VMLFTFTPFSIAGIIKSKN 318

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1958797261 244 LTLAPMYIWFM-IFFIQPHKEERFLFPVYPLICLCGAVALSALQ 286
Cdd:PLN02816  319 QKLSALILWVLaIYSILGHKEFRFVLPVLPIALIFSGYAFAQME 362
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 51-377 4.32e-87

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 273.86  E-value: 4.32e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797261  51 KLTRAVCKKFGLHVSRMMLAFLVLSTGMFCSSSAFLPSSFCMYTTLVAMTGW--------YMDKTPIAVLGVAAGAILGW 122
Cdd:pfam03901  97 YLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLleygntsvSNYKYLKAVLLIAALAILGR 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797261 123 PFSAALGLPIAFDLL--AMKHRWKSFF--LWSLAALVLFLVPVVVI--DSYYYGKLVIAPLNIVLYNVFtSHGPDLYGTE 196
Cdd:pfam03901 177 PTSALLWLPLVLYLLlrLRGKRLKLFLflAISLGLLVALLVLGAVIliDSYFYGRFVFTPLNFLKYNVL-SNGSSFYGTH 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797261 197 PWYFYLINGFLNFNVAFALALLVLPLTFLMEYLLQrfhvqnlghpYWLTLAPMYIWFMIFFIQPHKEERFLFPVYPLICL 276
Cdd:pfam03901 256 PWYFYFSNGLPNILGPFLLAFILGPLVLLLRKVSR----------LSQLLAPILIWLFIYSLQPHKEERFLYPVYPLILL 325

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797261 277 CGAVALSALQkcyhfvfQRYRLEHYTVTSSWLalgtvFLFGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIHTVPEG 356
Cdd:pfam03901 326 SAAIALTRLS-------RRSWKVRKKLSLLFL-----LLFFNVSLARLFGLVHQYGAPLAVYDVMSFLNETPRENRNPAG 393

                         330       340
                  ....*....|....*....|.
gi 1958797261 357 RPVNVCVGKEWYRFPSSFLLP 377
Cdd:pfam03901 394 PPVNVCIGMECYSTPSSFFLH 414
PLN02816 PLN02816
mannosyltransferase
 164-286 3.65e-08

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 55.81  E-value: 3.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797261 164 IDSYYYGKLVIAPLNIVLYNvFTSHGPDLYGTEPWYFYLINGFLnfnvafalallvlpltfLMEYLLQRFHVQNLGHPYW 243
Cdd:PLN02816  257 LDRLMYGSWVIVPLNFLKFN-FLSSGGDYYGTHPWHWYFTQGFL-----------------VMLFTFTPFSIAGIIKSKN 318

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1958797261 244 LTLAPMYIWFM-IFFIQPHKEERFLFPVYPLICLCGAVALSALQ 286
Cdd:PLN02816  319 QKLSALILWVLaIYSILGHKEFRFVLPVLPIALIFSGYAFAQME 362
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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