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Conserved domains on  [gi|1958795194|ref|XP_038937002|]
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serine-protein kinase ATM isoform X4 [Rattus norvegicus]

Protein Classification

ATM family protein( domain architecture ID 10569357)

ATM (ataxia telangiectasia mutated) family protein is a phosphoinositide 3-kinase-related protein kinase (PIKK) that displays intrinsic serine/threonine kinase activity and is distinguished from other PKs by its unique catalytic domain, similar to that of lipid PI3K

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TAN pfam11640
Telomere-length maintenance and DNA damage repair; ATM is a large protein kinase, in humans, ...
 8-165 4.95e-20

Telomere-length maintenance and DNA damage repair; ATM is a large protein kinase, in humans, critical for responding to DNA double-strand breaks (DSBs). Tel1, the orthologue from budding yeast, also regulates responses to DSBs. Tel1 is important for maintaining viability and for phosphorylation of the DNA damage signal transducer kinase Rad53 (an orthologue of mammalian CHK2). In addition to functioning in the response to DSBs, numerous findings indicate that Tel1/ATM regulates telomeres. The overall domain structure of Tel1/ATM is shared by proteins of the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family, but this family carries a unique and functionally important TAN sequence motif, near its N-terminal, LxxxKxxE/DRxxxL. which is conserved specifically in the Tel1/ATM subclass of the PIKKs. The TAN motif is essential for both telomere length maintenance and Tel1 action in response to DNA damage. It is classified as an EC:2.7.11.1.


:

Pssm-ID: 463317  Cd Length: 150  Bit Score: 88.53  E-value: 4.95e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795194    8 LLICCRQLEHDRATERRKEVDKFKRLIQDPETVQhlDRHSDSKQgkylnWDAVFRFLQKYIQKETESLRTAKSnvSASTQ 87
Cdd:pfam11640    1 LLEILSLLSSSKIKERNDALEDLKHILSSNRNKS--LSALNDKA-----WHSIFEALFRLIEAEKSAYLKAKK--SSTSK 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795194   88 TSRQKKMQEISSLVRFFIKCANKrapRLKcQDLLNYVMDTVKDSSNGAT------YGADCSNIlLKDILSVRKYWCEVSQ 161
Cdd:pfam11640   72 SAAARRLSSAASALRLVVEKAVS---RLK-RKTLKALLDHITQLLPLPDgellepLALDYSKA-LRSLLSYRPHVEHLDA 146


                   ....
gi 1958795194  162 QQWL 165
Cdd:pfam11640  147 EDWI 150
FAT super family cl26693
FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.
 2137-2186 4.17e-07

FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.


The actual alignment was detected with superfamily member pfam02259:

Pssm-ID: 396714 [Multi-domain]  Cd Length: 342  Bit Score: 54.28  E-value: 4.17e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958795194 2137 QELHYQAAWRNMQWDLCTSANQELEGTSYHESLYNALQCLRNREFSTFYD 2186
Cdd:pfam02259    1 APLAAEAAWRLGQWDLMREYLSLMKKDSPDKAFFEAILALHRNQFDEAER 50
 
Name Accession Description Interval E-value
TAN pfam11640
Telomere-length maintenance and DNA damage repair; ATM is a large protein kinase, in humans, ...
 8-165 4.95e-20

Telomere-length maintenance and DNA damage repair; ATM is a large protein kinase, in humans, critical for responding to DNA double-strand breaks (DSBs). Tel1, the orthologue from budding yeast, also regulates responses to DSBs. Tel1 is important for maintaining viability and for phosphorylation of the DNA damage signal transducer kinase Rad53 (an orthologue of mammalian CHK2). In addition to functioning in the response to DSBs, numerous findings indicate that Tel1/ATM regulates telomeres. The overall domain structure of Tel1/ATM is shared by proteins of the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family, but this family carries a unique and functionally important TAN sequence motif, near its N-terminal, LxxxKxxE/DRxxxL. which is conserved specifically in the Tel1/ATM subclass of the PIKKs. The TAN motif is essential for both telomere length maintenance and Tel1 action in response to DNA damage. It is classified as an EC:2.7.11.1.


Pssm-ID: 463317  Cd Length: 150  Bit Score: 88.53  E-value: 4.95e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795194    8 LLICCRQLEHDRATERRKEVDKFKRLIQDPETVQhlDRHSDSKQgkylnWDAVFRFLQKYIQKETESLRTAKSnvSASTQ 87
Cdd:pfam11640    1 LLEILSLLSSSKIKERNDALEDLKHILSSNRNKS--LSALNDKA-----WHSIFEALFRLIEAEKSAYLKAKK--SSTSK 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795194   88 TSRQKKMQEISSLVRFFIKCANKrapRLKcQDLLNYVMDTVKDSSNGAT------YGADCSNIlLKDILSVRKYWCEVSQ 161
Cdd:pfam11640   72 SAAARRLSSAASALRLVVEKAVS---RLK-RKTLKALLDHITQLLPLPDgellepLALDYSKA-LRSLLSYRPHVEHLDA 146


                   ....
gi 1958795194  162 QQWL 165
Cdd:pfam11640  147 EDWI 150
FAT pfam02259
FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.
 2137-2186 4.17e-07

FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.


Pssm-ID: 396714 [Multi-domain]  Cd Length: 342  Bit Score: 54.28  E-value: 4.17e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958795194 2137 QELHYQAAWRNMQWDLCTSANQELEGTSYHESLYNALQCLRNREFSTFYD 2186
Cdd:pfam02259    1 APLAAEAAWRLGQWDLMREYLSLMKKDSPDKAFFEAILALHRNQFDEAER 50
 
Name Accession Description Interval E-value
TAN pfam11640
Telomere-length maintenance and DNA damage repair; ATM is a large protein kinase, in humans, ...
 8-165 4.95e-20

Telomere-length maintenance and DNA damage repair; ATM is a large protein kinase, in humans, critical for responding to DNA double-strand breaks (DSBs). Tel1, the orthologue from budding yeast, also regulates responses to DSBs. Tel1 is important for maintaining viability and for phosphorylation of the DNA damage signal transducer kinase Rad53 (an orthologue of mammalian CHK2). In addition to functioning in the response to DSBs, numerous findings indicate that Tel1/ATM regulates telomeres. The overall domain structure of Tel1/ATM is shared by proteins of the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family, but this family carries a unique and functionally important TAN sequence motif, near its N-terminal, LxxxKxxE/DRxxxL. which is conserved specifically in the Tel1/ATM subclass of the PIKKs. The TAN motif is essential for both telomere length maintenance and Tel1 action in response to DNA damage. It is classified as an EC:2.7.11.1.


Pssm-ID: 463317  Cd Length: 150  Bit Score: 88.53  E-value: 4.95e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795194    8 LLICCRQLEHDRATERRKEVDKFKRLIQDPETVQhlDRHSDSKQgkylnWDAVFRFLQKYIQKETESLRTAKSnvSASTQ 87
Cdd:pfam11640    1 LLEILSLLSSSKIKERNDALEDLKHILSSNRNKS--LSALNDKA-----WHSIFEALFRLIEAEKSAYLKAKK--SSTSK 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795194   88 TSRQKKMQEISSLVRFFIKCANKrapRLKcQDLLNYVMDTVKDSSNGAT------YGADCSNIlLKDILSVRKYWCEVSQ 161
Cdd:pfam11640   72 SAAARRLSSAASALRLVVEKAVS---RLK-RKTLKALLDHITQLLPLPDgellepLALDYSKA-LRSLLSYRPHVEHLDA 146


                   ....
gi 1958795194  162 QQWL 165
Cdd:pfam11640  147 EDWI 150
FAT pfam02259
FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.
 2137-2186 4.17e-07

FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.


Pssm-ID: 396714 [Multi-domain]  Cd Length: 342  Bit Score: 54.28  E-value: 4.17e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958795194 2137 QELHYQAAWRNMQWDLCTSANQELEGTSYHESLYNALQCLRNREFSTFYD 2186
Cdd:pfam02259    1 APLAAEAAWRLGQWDLMREYLSLMKKDSPDKAFFEAILALHRNQFDEAER 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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