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Conserved domains on  [gi|1958793092|ref|XP_038936263|]
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A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 1222-1390 9.49e-86

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


:

Pssm-ID: 462559  Cd Length: 200  Bit Score: 277.96  E-value: 9.49e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958793092 1222 TTCKEIQVTNNITKDGNYDLNVRGRILKIHCSGMQLENPREYLPLVKVE-DNFSEIYGLRLQNPYECPFNGSRRADCACE 1300
Cdd:pfam08685    2 RSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPqENYSEVYGYRLKNPNECPFNGSRRDDCACR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958793092 1301 NDYPP-AGYTVFSKVRVDLASMQIKTTDLLFSRTLFGKAVPFATAGDCYSAARCPQGQFSINLAGTGMKVSSTAKWLAQG 1379
Cdd:pfam08685   82 QDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVSQG 161

                          170
                   ....*....|.
gi 1958793092 1380 RYASVIIHRSQ 1390
Cdd:pfam08685  162 NYAVSKIHRSQ 172
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 231-348 2.75e-30

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 116.14  E-value: 2.75e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958793092  231 TLAGVFNSAH-YGYNVVVKIPAGATNIEILQHSYSGrpeddNYLALSDTQGNFLLNGNFVVSMAKKEINIQGAVFEYSGS 309
Cdd:pfam05986    1 TVSGSFTEGRaKGYVTFVTIPAGATHIHIVNRKPSF-----THLAVKNVQGKYILNGKGSISLNPTYPSLLGTVLEYRRS 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958793092  310 NNSIERINSTDRLEAELVLQVLCV-GNLYNPDVHYIFNIP 348
Cdd:pfam05986   76 LPALEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 588-642 2.17e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.94  E-value: 2.17e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  588 WHVGPWGSCTVTCGHGYQVRAVKCVSEILGTVLDDRECPRASRPSDRQDCIFAPC 642
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 816-867 2.56e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.55  E-value: 2.56e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  816 WRTGPWGACSRSCAGGLQHRAVVCQDEDGRSATS---CEATSKPPESKHCGSGPC 867
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPdseCSAQKKPPETQSCNLKPC 55
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 1-55 3.84e-12

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


:

Pssm-ID: 465496  Cd Length: 68  Bit Score: 62.75  E-value: 3.84e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958793092    1 MFGPGSQVCPYLKQ--CRRLWCTsaEGVHKGCRTQHMPLADGTSCGPGMHCHRGLCV 55
Cdd:pfam17771   14 IFGPGSTFCPNGDEdvCSKLWCS--NPGGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 68-120 1.42e-11

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 60.68  E-value: 1.42e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1958793092    68 WGPWGPYSSCSRTCGGGIRSTARLCDRPEPRNGGRYCVGRRMKFRSCNTDSCP 120
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 719-771 8.65e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.62  E-value: 8.65e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  719 WQAGDWSPCSASCGHGKTTRRVLCVNYH--QLVDESYCDPEGRPVTEQECRLAAC 771
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 870-922 9.91e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.23  E-value: 9.91e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  870 WNYGDWGECTQTCGAGVKSRFVICQFPDGQMAQEHS-CE-LPKPPSMMQCHLRAC 922
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSeCSaQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 533-585 2.64e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.08  E-value: 2.64e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  533 WATSEWSECPVTCGKGMKQRQVWCQR--SEDPVGDDFCDASTKPESLGPCELRAC 585
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 984-1037 2.53e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.38  E-value: 2.53e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  984 WKANKWKECSVTCGSGVQQREVYCR-LRGTGRVAEDMCEPSTRPQVQRPCWHQDC 1037
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 125-229 4.29e-09

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 55.87  E-value: 4.29e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958793092  125 DFREKQCSDFDGKHFDIS-GLPPNVRW---LPKYSGIAVkdrCKLYCRVAGTTSFYQLKDRVADGTPCGTE------TND 194
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWgaaVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1958793092  195 ICVQGLCRQAGCDHVLNSKAKRDKCGVCGGDNSSC 229
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 928-981 8.02e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.84  E-value: 8.02e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  928 WYRGSWKSCSASCGKGIKYREVLCIDQVQRKLE-EKYCSHLHKPRTHKPCRSGRC 981
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVpDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1042-1095 3.25e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.30  E-value: 3.25e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092 1042 WTTGDWLDCSTSCKKKETYRLVKCVNERNMQ-VNESLCDPLTKPVSIKKCRNSHC 1095
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 664-715 3.62e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.30  E-value: 3.62e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958793092  664 WRHGSWTPCSVSCGRGSQARYVSCRDAHDG-VADELNCAHLPRPAEVSLCFSP 715
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsIVPDSECSAQKKPPETQSCNLK 53
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1167-1218 2.29e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.99  E-value: 2.29e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092 1167 WKVGKWSKCSVTCGNGIMERRVACRTENG---WPSDLCLKRLKPDAQKKCYANDC 1218
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 478-530 1.10e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 47.06  E-value: 1.10e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  478 WHYSEWSQCSRSCGGGEKTRESYCVNGFGHRL-AERECQELPR-VVLGNCNDFPC 530
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQKKpPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 416-469 1.71e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 40.90  E-value: 1.71e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958793092  416 WHITGKSDCSSQCGQGYRTLDVHCMKYSVHKgqtvPVGDQYCGDQLKPPNREPC 469
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS----IVPDSECSAQKKPPETQSC 50
 
Name Accession Description Interval E-value
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 1222-1390 9.49e-86

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


Pssm-ID: 462559  Cd Length: 200  Bit Score: 277.96  E-value: 9.49e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958793092 1222 TTCKEIQVTNNITKDGNYDLNVRGRILKIHCSGMQLENPREYLPLVKVE-DNFSEIYGLRLQNPYECPFNGSRRADCACE 1300
Cdd:pfam08685    2 RSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPqENYSEVYGYRLKNPNECPFNGSRRDDCACR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958793092 1301 NDYPP-AGYTVFSKVRVDLASMQIKTTDLLFSRTLFGKAVPFATAGDCYSAARCPQGQFSINLAGTGMKVSSTAKWLAQG 1379
Cdd:pfam08685   82 QDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVSQG 161

                          170
                   ....*....|.
gi 1958793092 1380 RYASVIIHRSQ 1390
Cdd:pfam08685  162 NYAVSKIHRSQ 172
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 231-348 2.75e-30

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 116.14  E-value: 2.75e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958793092  231 TLAGVFNSAH-YGYNVVVKIPAGATNIEILQHSYSGrpeddNYLALSDTQGNFLLNGNFVVSMAKKEINIQGAVFEYSGS 309
Cdd:pfam05986    1 TVSGSFTEGRaKGYVTFVTIPAGATHIHIVNRKPSF-----THLAVKNVQGKYILNGKGSISLNPTYPSLLGTVLEYRRS 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958793092  310 NNSIERINSTDRLEAELVLQVLCV-GNLYNPDVHYIFNIP 348
Cdd:pfam05986   76 LPALEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 588-642 2.17e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.94  E-value: 2.17e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  588 WHVGPWGSCTVTCGHGYQVRAVKCVSEILGTVLDDRECPRASRPSDRQDCIFAPC 642
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 816-867 2.56e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.55  E-value: 2.56e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  816 WRTGPWGACSRSCAGGLQHRAVVCQDEDGRSATS---CEATSKPPESKHCGSGPC 867
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPdseCSAQKKPPETQSCNLKPC 55
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 1-55 3.84e-12

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 62.75  E-value: 3.84e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958793092    1 MFGPGSQVCPYLKQ--CRRLWCTsaEGVHKGCRTQHMPLADGTSCGPGMHCHRGLCV 55
Cdd:pfam17771   14 IFGPGSTFCPNGDEdvCSKLWCS--NPGGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 68-120 1.42e-11

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 60.68  E-value: 1.42e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1958793092    68 WGPWGPYSSCSRTCGGGIRSTARLCDRPEPRNGGRYCVGRRMKFRSCNTDSCP 120
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 719-771 8.65e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.62  E-value: 8.65e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  719 WQAGDWSPCSASCGHGKTTRRVLCVNYH--QLVDESYCDPEGRPVTEQECRLAAC 771
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 870-922 9.91e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.23  E-value: 9.91e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  870 WNYGDWGECTQTCGAGVKSRFVICQFPDGQMAQEHS-CE-LPKPPSMMQCHLRAC 922
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSeCSaQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 533-585 2.64e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.08  E-value: 2.64e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  533 WATSEWSECPVTCGKGMKQRQVWCQR--SEDPVGDDFCDASTKPESLGPCELRAC 585
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 984-1037 2.53e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.38  E-value: 2.53e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  984 WKANKWKECSVTCGSGVQQREVYCR-LRGTGRVAEDMCEPSTRPQVQRPCWHQDC 1037
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 125-229 4.29e-09

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 55.87  E-value: 4.29e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958793092  125 DFREKQCSDFDGKHFDIS-GLPPNVRW---LPKYSGIAVkdrCKLYCRVAGTTSFYQLKDRVADGTPCGTE------TND 194
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWgaaVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1958793092  195 ICVQGLCRQAGCDHVLNSKAKRDKCGVCGGDNSSC 229
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 928-981 8.02e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.84  E-value: 8.02e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  928 WYRGSWKSCSASCGKGIKYREVLCIDQVQRKLE-EKYCSHLHKPRTHKPCRSGRC 981
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVpDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1042-1095 3.25e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.30  E-value: 3.25e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092 1042 WTTGDWLDCSTSCKKKETYRLVKCVNERNMQ-VNESLCDPLTKPVSIKKCRNSHC 1095
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 664-715 3.62e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.30  E-value: 3.62e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958793092  664 WRHGSWTPCSVSCGRGSQARYVSCRDAHDG-VADELNCAHLPRPAEVSLCFSP 715
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsIVPDSECSAQKKPPETQSCNLK 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1167-1218 2.29e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.99  E-value: 2.29e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092 1167 WKVGKWSKCSVTCGNGIMERRVACRTENG---WPSDLCLKRLKPDAQKKCYANDC 1218
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 478-530 1.10e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 47.06  E-value: 1.10e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  478 WHYSEWSQCSRSCGGGEKTRESYCVNGFGHRL-AERECQELPR-VVLGNCNDFPC 530
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQKKpPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 716-771 1.75e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 46.43  E-value: 1.75e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958793092   716 CGEWqaGDWSPCSASCGHGKTTRRVLCVNYHQLVDESYCDpeGRPVTEQECRLAAC 771
Cdd:smart00209    1 WSEW--SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCT--GEDVETRACNEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 69-119 1.23e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 43.81  E-value: 1.23e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958793092   69 GPWGPYSSCSRTCGGGIRSTARLCDRPePRNGGRYCvGRRMKFRSCNTDSC 119
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 533-585 8.05e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.80  E-value: 8.05e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1958793092   533 WATSEWSECPVTCGKGMKQRQVWCQRSEDPVGDDFCDaSTKPESLgPCELRAC 585
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCT-GEDVETR-ACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 416-469 1.71e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 40.90  E-value: 1.71e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958793092  416 WHITGKSDCSSQCGQGYRTLDVHCMKYSVHKgqtvPVGDQYCGDQLKPPNREPC 469
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS----IVPDSECSAQKKPPETQSC 50
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 478-531 3.04e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.88  E-value: 3.04e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1958793092   478 WHYSEWSQCSRSCGGGEKTRESYCVNgFGHRLAERECQELPRVVLgNCNDFPCP 531
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCS-PPPQNGGGPCTGEDVETR-ACNEQPCP 53
 
Name Accession Description Interval E-value
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 1222-1390 9.49e-86

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


Pssm-ID: 462559  Cd Length: 200  Bit Score: 277.96  E-value: 9.49e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958793092 1222 TTCKEIQVTNNITKDGNYDLNVRGRILKIHCSGMQLENPREYLPLVKVE-DNFSEIYGLRLQNPYECPFNGSRRADCACE 1300
Cdd:pfam08685    2 RSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPqENYSEVYGYRLKNPNECPFNGSRRDDCACR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958793092 1301 NDYPP-AGYTVFSKVRVDLASMQIKTTDLLFSRTLFGKAVPFATAGDCYSAARCPQGQFSINLAGTGMKVSSTAKWLAQG 1379
Cdd:pfam08685   82 QDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVSQG 161

                          170
                   ....*....|.
gi 1958793092 1380 RYASVIIHRSQ 1390
Cdd:pfam08685  162 NYAVSKIHRSQ 172
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 231-348 2.75e-30

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 116.14  E-value: 2.75e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958793092  231 TLAGVFNSAH-YGYNVVVKIPAGATNIEILQHSYSGrpeddNYLALSDTQGNFLLNGNFVVSMAKKEINIQGAVFEYSGS 309
Cdd:pfam05986    1 TVSGSFTEGRaKGYVTFVTIPAGATHIHIVNRKPSF-----THLAVKNVQGKYILNGKGSISLNPTYPSLLGTVLEYRRS 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958793092  310 NNSIERINSTDRLEAELVLQVLCV-GNLYNPDVHYIFNIP 348
Cdd:pfam05986   76 LPALEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 588-642 2.17e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.94  E-value: 2.17e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  588 WHVGPWGSCTVTCGHGYQVRAVKCVSEILGTVLDDRECPRASRPSDRQDCIFAPC 642
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 816-867 2.56e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.55  E-value: 2.56e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  816 WRTGPWGACSRSCAGGLQHRAVVCQDEDGRSATS---CEATSKPPESKHCGSGPC 867
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPdseCSAQKKPPETQSCNLKPC 55
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 1-55 3.84e-12

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 62.75  E-value: 3.84e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958793092    1 MFGPGSQVCPYLKQ--CRRLWCTsaEGVHKGCRTQHMPLADGTSCGPGMHCHRGLCV 55
Cdd:pfam17771   14 IFGPGSTFCPNGDEdvCSKLWCS--NPGGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 68-120 1.42e-11

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 60.68  E-value: 1.42e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1958793092    68 WGPWGPYSSCSRTCGGGIRSTARLCDRPEPRNGGRYCVGRRMKFRSCNTDSCP 120
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 719-771 8.65e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.62  E-value: 8.65e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  719 WQAGDWSPCSASCGHGKTTRRVLCVNYH--QLVDESYCDPEGRPVTEQECRLAAC 771
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 870-922 9.91e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.23  E-value: 9.91e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  870 WNYGDWGECTQTCGAGVKSRFVICQFPDGQMAQEHS-CE-LPKPPSMMQCHLRAC 922
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSeCSaQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 533-585 2.64e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.08  E-value: 2.64e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  533 WATSEWSECPVTCGKGMKQRQVWCQR--SEDPVGDDFCDASTKPESLGPCELRAC 585
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkgGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 984-1037 2.53e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.38  E-value: 2.53e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  984 WKANKWKECSVTCGSGVQQREVYCR-LRGTGRVAEDMCEPSTRPQVQRPCWHQDC 1037
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 125-229 4.29e-09

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 55.87  E-value: 4.29e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958793092  125 DFREKQCSDFDGKHFDIS-GLPPNVRW---LPKYSGIAVkdrCKLYCRVAGTTSFYQLKDRVADGTPCGTE------TND 194
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWgaaVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1958793092  195 ICVQGLCRQAGCDHVLNSKAKRDKCGVCGGDNSSC 229
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 928-981 8.02e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.84  E-value: 8.02e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  928 WYRGSWKSCSASCGKGIKYREVLCIDQVQRKLE-EKYCSHLHKPRTHKPCRSGRC 981
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVpDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1042-1095 3.25e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.30  E-value: 3.25e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092 1042 WTTGDWLDCSTSCKKKETYRLVKCVNERNMQ-VNESLCDPLTKPVSIKKCRNSHC 1095
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 664-715 3.62e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.30  E-value: 3.62e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958793092  664 WRHGSWTPCSVSCGRGSQARYVSCRDAHDG-VADELNCAHLPRPAEVSLCFSP 715
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsIVPDSECSAQKKPPETQSCNLK 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1167-1218 2.29e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.99  E-value: 2.29e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092 1167 WKVGKWSKCSVTCGNGIMERRVACRTENG---WPSDLCLKRLKPDAQKKCYANDC 1218
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 478-530 1.10e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 47.06  E-value: 1.10e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958793092  478 WHYSEWSQCSRSCGGGEKTRESYCVNGFGHRL-AERECQELPR-VVLGNCNDFPC 530
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQKKpPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 716-771 1.75e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 46.43  E-value: 1.75e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958793092   716 CGEWqaGDWSPCSASCGHGKTTRRVLCVNYHQLVDESYCDpeGRPVTEQECRLAAC 771
Cdd:smart00209    1 WSEW--SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCT--GEDVETRACNEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 69-119 1.23e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 43.81  E-value: 1.23e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958793092   69 GPWGPYSSCSRTCGGGIRSTARLCDRPePRNGGRYCvGRRMKFRSCNTDSC 119
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
69-119 2.67e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 42.79  E-value: 2.67e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958793092   69 GPWGPYSSCSRTCGGGIRSTARLCDRPEPrnGGRYCVGRRMKFRSCNTDSC 119
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 533-585 8.05e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.80  E-value: 8.05e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1958793092   533 WATSEWSECPVTCGKGMKQRQVWCQRSEDPVGDDFCDaSTKPESLgPCELRAC 585
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCT-GEDVETR-ACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 416-469 1.71e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 40.90  E-value: 1.71e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958793092  416 WHITGKSDCSSQCGQGYRTLDVHCMKYSVHKgqtvPVGDQYCGDQLKPPNREPC 469
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS----IVPDSECSAQKKPPETQSC 50
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 478-531 3.04e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.88  E-value: 3.04e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1958793092   478 WHYSEWSQCSRSCGGGEKTRESYCVNgFGHRLAERECQELPRVVLgNCNDFPCP 531
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCS-PPPQNGGGPCTGEDVETR-ACNEQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 473-497 5.82e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 39.18  E-value: 5.82e-04
                           10        20
                   ....*....|....*....|....*
gi 1958793092  473 CVLTRWhySEWSQCSRSCGGGEKTR 497
Cdd:pfam19028    1 CVVSEW--SEWSECSVTCGGGVQTR 23
TSP_1 pfam00090
Thrombospondin type 1 domain;
535-557 2.89e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 37.01  E-value: 2.89e-03
                           10        20
                   ....*....|....*....|...
gi 1958793092  535 TSEWSECPVTCGKGMKQRQVWCQ 557
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTCK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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