|
Name |
Accession |
Description |
Interval |
E-value |
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
201-438 |
7.56e-08 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 56.20 E-value: 7.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 201 PALQPSPQPVQFSPSSCPQVLLPVSPPQQ-----------YNMAEDLSNPFGQMSLSRQGSTEAADPSSALFQSPLISQH 269
Cdd:pfam09770 107 PAARAAQSSAQPPASSLPQYQYASQQSQQpskpvrtgyekYKEPEPIPDLQVDASLWGVAPKKAAAPAPAPQPAAQPASL 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 270 PQQASFIM------------ASAGQPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQvsyyPPGQYPNSNQQYRPLSHP 337
Cdd:pfam09770 187 PAPSRKMMsleeveaamraqAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQ----QPQQQPQQPQQHPGQGHP 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 338 VAYspqrgQQLPQASQQPGLQPMMSSQQQTAYQGMLGVQQPQNQGLlsnQRSNSMGGQMQGLVVQYTPLPSYQVPVGSES 417
Cdd:pfam09770 263 VTI-----LQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQIL---QNPNRLSAARVGYPQNPQPGVQPAPAHQAHR 334
|
250 260
....*....|....*....|.
gi 1958790360 418 QNVVQPPfQQPMLVPASQSVQ 438
Cdd:pfam09770 335 QQGSFGR-QAPIITHPQQLAQ 354
|
|
| SUZ |
pfam12752 |
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched ... |
2-32 |
8.99e-08 |
|
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character.
Pssm-ID: 463689 [Multi-domain] Cd Length: 56 Bit Score: 49.24 E-value: 8.99e-08
10 20 30
....*....|....*....|....*....|.
gi 1958790360 2 RVPLQDGRRSKSIEEREEEYQRVRERIFARE 32
Cdd:pfam12752 25 GASSSSGSDSKTLEEREAEYAEARARIFGSS 55
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
295-408 |
1.60e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 45.46 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 295 APPTQQVLPPQGYMQPPQQI--QVSYYPPGQYPNSNQQYRPLSHPVAYSPQRGQ-QLPQASQQPGLQPMMSSQQQTAYqg 371
Cdd:PRK10263 753 QQPQQPVAPQQQYQQPQQPVapQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQpQQPVAPQPQYQQPQQPVAPQPQY-- 830
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1958790360 372 mlgvQQPQNQGLLSNQRS-----NSMGGQMQGLVVQYTPLPS 408
Cdd:PRK10263 831 ----QQPQQPVAPQPQDTllhplLMRNGDSRPLHKPTTPLPS 868
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
343-478 |
2.54e-04 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 44.41 E-value: 2.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 343 QRGQQLPQASQQPGLQPMMSSQQQTAYQGMLGVQQPQNQGLLSNQRSNSMGGQMQGLVVQYTPLPSYqVPVGSESQNVVQ 422
Cdd:TIGR01628 374 QFMQLQPRMRQLPMGSPMGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLRPNGLAPM-NAVRAPSRNAQN 452
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1958790360 423 PPFQQPML-VPASQSVQGGLPAGGVPVYYSVIPPAQQNGTSPSVGFLQPPGsEQYQM 478
Cdd:TIGR01628 453 AAQKPPMQpVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQ-MQKQV 508
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
422-578 |
1.07e-03 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 42.72 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 422 QPPFQQPMLVPASQsvqgglpaggvPVYYSVIPPAQQNGTSPSVGFLQPPGSEQYQMPQSPAPCSPPQI------PQQYS 495
Cdd:pfam09770 208 KKPAQQPAPAPAQP-----------PAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTIlqrpqsPQPDP 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 496 GVSPSGPGVVVMQLNVPNGPQAP----QNPSMVQWGHCKYYSVDQRGQKPgdlyspdGDPQTNAQMGSSPVTSPTQSPAP 571
Cdd:pfam09770 277 AQPSIQPQAQQFHQQPPPVPVQPtqilQNPNRLSAARVGYPQNPQPGVQP-------APAHQAHRQQGSFGRQAPIITHP 349
|
....*..
gi 1958790360 572 SPVTSLS 578
Cdd:pfam09770 350 QQLAQLS 356
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
201-438 |
7.56e-08 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 56.20 E-value: 7.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 201 PALQPSPQPVQFSPSSCPQVLLPVSPPQQ-----------YNMAEDLSNPFGQMSLSRQGSTEAADPSSALFQSPLISQH 269
Cdd:pfam09770 107 PAARAAQSSAQPPASSLPQYQYASQQSQQpskpvrtgyekYKEPEPIPDLQVDASLWGVAPKKAAAPAPAPQPAAQPASL 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 270 PQQASFIM------------ASAGQPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQvsyyPPGQYPNSNQQYRPLSHP 337
Cdd:pfam09770 187 PAPSRKMMsleeveaamraqAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQ----QPQQQPQQPQQHPGQGHP 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 338 VAYspqrgQQLPQASQQPGLQPMMSSQQQTAYQGMLGVQQPQNQGLlsnQRSNSMGGQMQGLVVQYTPLPSYQVPVGSES 417
Cdd:pfam09770 263 VTI-----LQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQIL---QNPNRLSAARVGYPQNPQPGVQPAPAHQAHR 334
|
250 260
....*....|....*....|.
gi 1958790360 418 QNVVQPPfQQPMLVPASQSVQ 438
Cdd:pfam09770 335 QQGSFGR-QAPIITHPQQLAQ 354
|
|
| SUZ |
pfam12752 |
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched ... |
2-32 |
8.99e-08 |
|
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character.
Pssm-ID: 463689 [Multi-domain] Cd Length: 56 Bit Score: 49.24 E-value: 8.99e-08
10 20 30
....*....|....*....|....*....|.
gi 1958790360 2 RVPLQDGRRSKSIEEREEEYQRVRERIFARE 32
Cdd:pfam12752 25 GASSSSGSDSKTLEEREAEYAEARARIFGSS 55
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
199-525 |
1.81e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 54.77 E-value: 1.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 199 PVPALQPSPQPVQFSPSSCPQVLLPVSPP--QQYNMAEDLSNPFGQMSLSRQGSTEAADPSSALFQSPLISQHPQQA--S 274
Cdd:pfam03154 189 PGTTQAATAGPTPSAPSVPPQGSPATSQPpnQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPlpQ 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 275 FIMASAGQPLPTSNYSTSSHAPptqQVLPPQGYMQPPQ--QIQVSYYPPGQYPNSNQQ--YRPLSHPVAYSPQ--RGQQL 348
Cdd:pfam03154 269 PSLHGQMPPMPHSLQTGPSHMQ---HPVPPQPFPLTPQssQSQVPPGPSPAAPGQSQQriHTPPSQSQLQSQQppREQPL 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 349 PQAsqqPGLQPMMSSQQQTAYQGMLGVQQPQNQGLLSNQRSNSMGGQMqglvvqytPLPSYQVPVGSESQNvvQPPFQQP 428
Cdd:pfam03154 346 PPA---PLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNL--------PPPPALKPLSSLSTH--HPPSAHP 412
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 429 ---MLVPASQSVQGGLPAGGVPVYYSVIPPAQQNGTSPSV---GFLQPPGSEQYQMPQSPAPCSPPQIPQqySGVSPSGP 502
Cdd:pfam03154 413 pplQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGlhqVPSQSPFPQHPFVPGGPPPITPPSGPP--TSTSSAMP 490
|
330 340 350
....*....|....*....|....*....|
gi 1958790360 503 GV-------VVMQLNVPNGPQAPQNPSMVQ 525
Cdd:pfam03154 491 GIqppssasVSSSGPVPAAVSCPLPPVQIK 520
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
295-408 |
1.60e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 45.46 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 295 APPTQQVLPPQGYMQPPQQI--QVSYYPPGQYPNSNQQYRPLSHPVAYSPQRGQ-QLPQASQQPGLQPMMSSQQQTAYqg 371
Cdd:PRK10263 753 QQPQQPVAPQQQYQQPQQPVapQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQpQQPVAPQPQYQQPQQPVAPQPQY-- 830
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1958790360 372 mlgvQQPQNQGLLSNQRS-----NSMGGQMQGLVVQYTPLPS 408
Cdd:PRK10263 831 ----QQPQQPVAPQPQDTllhplLMRNGDSRPLHKPTTPLPS 868
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
254-504 |
2.28e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 45.08 E-value: 2.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 254 ADPSSALFQSPLISQhPQQASFIMASAGQPLPTSNYSTSSHAPPtqqvlpPQGYMQPPQ--QIQVSYYPPGQYPNSNQQy 331
Cdd:PRK10263 334 AAPVEPVTQTPPVAS-VDVPPAQPTVAWQPVPGPQTGEPVIAPA------PEGYPQQSQyaQPAVQYNEPLQQPVQPQQ- 405
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 332 rPLSHPVAYSPQRGQQLPQASQQPGLQPMMSSQQQTAYQGMLGVQQPQNQgLLSNQRSnsmggqmqglvvqYTPLPSYQV 411
Cdd:PRK10263 406 -PYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQS-TFAPQST-------------YQTEQTYQQ 470
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 412 PVGSESQNVVQPPFQQPMLVPASQSVQGGLPAGGVPVYYSVIPPAQQNGTSPSVGFLQP---PGSEQYQMPQSPAPCSPP 488
Cdd:PRK10263 471 PAAQEPLYQQPQPVEQQPVVEPEPVVEETKPARPPLYYFEEVEEKRAREREQLAAWYQPipePVKEPEPIKSSLKAPSVA 550
|
250
....*....|....*...
gi 1958790360 489 QIP--QQYSGVSPSGPGV 504
Cdd:PRK10263 551 AVPpvEAAAAVSPLASGV 568
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
343-478 |
2.54e-04 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 44.41 E-value: 2.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 343 QRGQQLPQASQQPGLQPMMSSQQQTAYQGMLGVQQPQNQGLLSNQRSNSMGGQMQGLVVQYTPLPSYqVPVGSESQNVVQ 422
Cdd:TIGR01628 374 QFMQLQPRMRQLPMGSPMGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLRPNGLAPM-NAVRAPSRNAQN 452
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1958790360 423 PPFQQPML-VPASQSVQGGLPAGGVPVYYSVIPPAQQNGTSPSVGFLQPPGsEQYQM 478
Cdd:TIGR01628 453 AAQKPPMQpVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQ-MQKQV 508
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
196-355 |
2.95e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 44.69 E-value: 2.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 196 ISQPVPALQPSPQPVQFSPSSCPQVLLPVSPPQQYNMAEDLSNPFGQMSLSRQGSTEAADPSSAlfQSPLISQHPQQASF 275
Cdd:PRK10263 353 PAQPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPA--QQPYYAPAPEQPAQ 430
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 276 IMASAGQPlPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQVSYYPPGQYpnsnQQYRPLSHPVAYSPQRGQQLPQASQQP 355
Cdd:PRK10263 431 QPYYAPAP-EQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLY----QQPQPVEQQPVVEPEPVVEETKPARPP 505
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
256-355 |
3.43e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 44.31 E-value: 3.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 256 PSSALFQSPLISQHPQQASFIMASAGQPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQI--QVSYYPPGQYPNSNQQYRP 333
Cdd:PRK10263 740 PHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVapQPQYQQPQQPVAPQPQYQQ 819
|
90 100
....*....|....*....|..
gi 1958790360 334 LSHPVAYSPQRGQQLPQASQQP 355
Cdd:PRK10263 820 PQQPVAPQPQYQQPQQPVAPQP 841
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
422-578 |
1.07e-03 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 42.72 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 422 QPPFQQPMLVPASQsvqgglpaggvPVYYSVIPPAQQNGTSPSVGFLQPPGSEQYQMPQSPAPCSPPQI------PQQYS 495
Cdd:pfam09770 208 KKPAQQPAPAPAQP-----------PAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTIlqrpqsPQPDP 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 496 GVSPSGPGVVVMQLNVPNGPQAP----QNPSMVQWGHCKYYSVDQRGQKPgdlyspdGDPQTNAQMGSSPVTSPTQSPAP 571
Cdd:pfam09770 277 AQPSIQPQAQQFHQQPPPVPVQPtqilQNPNRLSAARVGYPQNPQPGVQP-------APAHQAHRQQGSFGRQAPIITHP 349
|
....*..
gi 1958790360 572 SPVTSLS 578
Cdd:pfam09770 350 QQLAQLS 356
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
254-599 |
3.26e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.91 E-value: 3.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 254 ADPSSALFQSPLISQHPQ-QASFIMASAGQPLPTSNYSTSSHAP-PTQQVLPPQGY---MQPPQQIQvSYYPPGQYPNSN 328
Cdd:pfam03154 156 SDSDSSAQQQILQTQPPVlQAQSGAASPPSPPPPGTTQAATAGPtPSAPSVPPQGSpatSQPPNQTQ-STAAPHTLIQQT 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 329 QQYRPLSHPVAYSPQRGQQLPQASQQPGLQPMMSSQQQTAYQGMLGVQQPQNQGLLSNQRSNSMGGQMQGLVVQYTPLPS 408
Cdd:pfam03154 235 PTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPS 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 409 YQVPvGSESQNVVQPPFQqpmlvPASQSVQgglpaggvPVYYSVIPPAQQngtspSVGFLQPPGSEQyqMPQSPAPCSPP 488
Cdd:pfam03154 315 PAAP-GQSQQRIHTPPSQ-----SQLQSQQ--------PPREQPLPPAPL-----SMPHIKPPPTTP--IPQLPNPQSHK 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 489 QIPQQysgvspSGPGVVVMQLNVPNGPQapqnpsmvqwghCKYYSVDQRGQKPGDLYSPDGDPQTNAQMGSSPVTSP--T 566
Cdd:pfam03154 374 HPPHL------SGPSPFQMNSNLPPPPA------------LKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPvlT 435
|
330 340 350
....*....|....*....|....*....|....*..
gi 1958790360 567 QSPAPSPVTSLSSVCTGLSPLPVLTPFPR----PGGP 599
Cdd:pfam03154 436 QSQSLPPPAASHPPTSGLHQVPSQSPFPQhpfvPGGP 472
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
319-474 |
3.63e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 40.84 E-value: 3.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 319 YPPGQYPNSNQQYRPLSHPVAYSPQRgqqlPQASQQPGLQPMMSSQQQTAYQGMLGVQQPQNQGLLSNQrsnsmggqmqg 398
Cdd:PRK10263 745 FTPIVEPVQQPQQPVAPQQQYQQPQQ----PVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQ----------- 809
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 399 lvvQYTPLPSYQVPvgsESQNVVQPPFQQPMLVPASQsvqgglpaggvPVYYSVIPPAQQNGTS----------PSVGFL 468
Cdd:PRK10263 810 ---PVAPQPQYQQP---QQPVAPQPQYQQPQQPVAPQ-----------PQDTLLHPLLMRNGDSrplhkpttplPSLDLL 872
|
....*.
gi 1958790360 469 QPPGSE 474
Cdd:PRK10263 873 TPPPSE 878
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
236-406 |
3.70e-03 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 40.56 E-value: 3.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 236 LSNPFGQMSLSRQGSTEAADPSSALFQSPLISQHPQQASfimasAGQPLptsNYstsshaPPTQQVLPPQGYMQPPQQIQ 315
Cdd:TIGR01628 371 LQDQFMQLQPRMRQLPMGSPMGGAMGQPPYYGQGPQQQF-----NGQPL---GW------PRMSMMPTPMGPGGPLRPNG 436
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 316 VSYYPPGQYPNSNQQYRPLSHPVA---YSPQ-RGQQLPQASQQPGLQPMMSSQQQTAYQgMLGVQQPQnqgllsnQRSNS 391
Cdd:TIGR01628 437 LAPMNAVRAPSRNAQNAAQKPPMQpvmYPPNyQSLPLSQDLPQPQSTASQGGQNKKLAQ-VLASATPQ-------MQKQV 508
|
170
....*....|....*
gi 1958790360 392 MGGQMQGLVVQYTPL 406
Cdd:TIGR01628 509 LGERLFPLVEAIEPA 523
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
191-506 |
3.96e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.91 E-value: 3.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 191 LNNHMISQPVPALQPSPQPVQfSPSSCPQvllPVSPPQQYNMAEDLSNPF--GQMSLSRQGSTEAADPSSALFQSPlISQ 268
Cdd:pfam03154 237 LHPQRLPSPHPPLQPMTQPPP-PSQVSPQ---PLPQPSLHGQMPPMPHSLqtGPSHMQHPVPPQPFPLTPQSSQSQ-VPP 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 269 HPQQASFIMASAGQPLPTSNYSTSSHAPPTQQVLPPqGYMQPPQQIQVSYYPPGQYPNSNQQYRPlSHPVAYSP-QRGQQ 347
Cdd:pfam03154 312 GPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPP-APLSMPHIKPPPTTPIPQLPNPQSHKHP-PHLSGPSPfQMNSN 389
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 348 LPQASQQPGLQPMMSSQQQTAYQGMLGVqQPQNQGLLSNQRSNSMGGQMQGLvvqyTPLPSYQVPVGSESQNVVQPPFQQ 427
Cdd:pfam03154 390 LPPPPALKPLSSLSTHHPPSAHPPPLQL-MPQSQQLPPPPAQPPVLTQSQSL----PPPAASHPPTSGLHQVPSQSPFPQ 464
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 428 PMLVPASQSVQggLPAGGVPVYYSVIPPAQQNGTSPSVGFLQP-PGSEQYQMP----------QSPAPCSPPQIPQqysg 496
Cdd:pfam03154 465 HPFVPGGPPPI--TPPSGPPTSTSSAMPGIQPPSSASVSSSGPvPAAVSCPLPpvqikeealdEAEEPESPPPPPR---- 538
|
330
....*....|
gi 1958790360 497 vSPSGPGVVV 506
Cdd:pfam03154 539 -SPSPEPTVV 547
|
|
| G_path_suppress |
pfam15991 |
G-protein pathway suppressor; This family of proteins inhibits G-protein- and ... |
202-361 |
5.80e-03 |
|
G-protein pathway suppressor; This family of proteins inhibits G-protein- and mitogen-activated protein kinase-mediated signal transduction.
Pssm-ID: 464961 [Multi-domain] Cd Length: 272 Bit Score: 39.52 E-value: 5.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 202 ALQPSPQPVQFSPSS-CPQVLLPVSPPQQYNMAEDLSNPFGQMSLSRQGSTEAADPSSALFQSPLISQHPQQASFIMASA 280
Cdd:pfam15991 103 ALQQAAAQVFLPQLSmQGQPHHQQHPGPQVGVLKRTRSPSPPVQQQAYYKQPAFSPGYAEHGQQKHDDGRRGYDVARFGS 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 281 GQPLPTSNYSTSSHAPPTQQVLPP-QGYMQPPQQIQVSYYPPGQYPNSNQQYRPLSHPVAY---SPQRGQQLPQA--SQQ 354
Cdd:pfam15991 183 WNKSTAQYPPSGQLFYPTHQYLPPpQTQGQADARLQTIYPQPGYALPLQQQYEHANQPSPFvssSPLKQMQSPKAgpGPQ 262
|
....*..
gi 1958790360 355 PGLQPMM 361
Cdd:pfam15991 263 PMQLSVL 269
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
198-600 |
7.28e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 39.92 E-value: 7.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 198 QPVPALQPSPQPVQfsPSSCPQVLLPVSPPQQyNMAEDLSNPFGQMSLSRQGSTEAADPSSALFQSPLISQHPQQASFIM 277
Cdd:PHA03247 2566 RSVPPPRPAPRPSE--PAVTSRARRPDAPPQS-ARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHP 2642
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 278 ASAGQPLPTSNYS-----------TSSHAPPTQQVLPPQGYMQPPQQIQV-----SYYPPGQYPNSNQQYRPLShPVAYS 341
Cdd:PHA03247 2643 PPTVPPPERPRDDpapgrvsrprrARRLGRAAQASSPPQRPRRRAARPTVgsltsLADPPPPPPTPEPAPHALV-SATPL 2721
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 342 PQRGQQLPQASQQPGLQPMMSSQQQTAYQGMLGVQQPQNQGLLSNQRSNSMGGQMQGLVVQYTPLPSYQVPVGSESQNVV 421
Cdd:PHA03247 2722 PPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSP 2801
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 422 QPPFQQPMLVPASQSV--QGGLPAGGVPVYYSVIP--PAQQNGTSPSV----GFLQPPGSEQYQMPQSPAPCSP--PQIP 491
Cdd:PHA03247 2802 WDPADPPAAVLAPAAAlpPAASPAGPLPPPTSAQPtaPPPPPGPPPPSlplgGSVAPGGDVRRRPPSRSPAAKPaaPARP 2881
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790360 492 QQYSGVSPSGPGVVVMQLNVPNGPQAPQNPSMVQwghckyYSVDQRGQKPGDLYSPDGDPQTNAQMGSSPVTSPTQSPAP 571
Cdd:PHA03247 2882 PVRRLARPAVSRSTESFALPPDQPERPPQPQAPP------PPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP 2955
|
410 420 430
....*....|....*....|....*....|...
gi 1958790360 572 SPVTS---LSSVCTGLSPLP-VLTPFPRPGGPA 600
Cdd:PHA03247 2956 SGAVPqpwLGALVPGRVAVPrFRVPQPAPSREA 2988
|
|
| |
