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Conserved domains on  [gi|1958789653|ref|XP_038935155|]
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lysosomal-associated transmembrane protein 4B isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mtp super family cl04276
Golgi 4-transmembrane spanning transporter;
73-229 2.45e-23

Golgi 4-transmembrane spanning transporter;


The actual alignment was detected with superfamily member TIGR00799:

Pssm-ID: 470991  Cd Length: 258  Bit Score: 94.28  E-value: 2.45e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789653  73 NMCIAIAISLLM--------------------ILICAMATYGAYKQHAA-----------WIIPFFCYQIFDFALNTLVA 121
Cdd:TIGR00799  68 NALFIISVSLLMgvvknrekylypflslqimdFLLCLLTLLGSYIELPAylklarprpgpSKIPLMTLQLLDFCLSILTL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789653 122 ITVLVY--PNSIQEYIRQLPpSFPYRDDIMSVNPTCLVLVILLFIGIILTFKGYLISCVWSCYRYINGRNSsdVLVYVTS 199
Cdd:TIGR00799 148 CSSYMEvpTYLNFKSMNHMN-YLPSQEDLPHLQFICMMFIFSVAFITVLIFKVYMFKCVWNCYKYIKNMNS--IAEYPAS 224

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958789653 200 ND-TTVLLPPYDDATAV---TGTAKEPPPPYVSA 229
Cdd:TIGR00799 225 KMpPKVVLPSYEEALSLpekTPEGDPAPPPYSEV 258
 
Name Accession Description Interval E-value
mtp TIGR00799
Golgi 4-transmembrane spanning transporter; The proteins of the MET family have 4 TMS regions ...
 73-229 2.45e-23

Golgi 4-transmembrane spanning transporter; The proteins of the MET family have 4 TMS regions and are located in late endosomal or lysosomal membranes. Substrates of the mouse MTP transporter include thymidine, both nucleoside and nucleobase analogues, antibiotics, anthracyclines, ionophores and steroid hormones. MET transporters may be involved in the subcellular compartmentation of steroid hormones and other compounds.Drug sensitivity by mouse MET was regulated by compounds that inhibit lysosomal function, interface with intracellular cholesterol transport, or modulate the multidrug resistance phenotype of mammalian cells. Thus, MET family members may compartmentalize diverse hydrophobic molecules, thereby affecting cellular drug sensitivity,nucleoside/nucleobase availability and steroid hormone responses. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273274  Cd Length: 258  Bit Score: 94.28  E-value: 2.45e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789653  73 NMCIAIAISLLM--------------------ILICAMATYGAYKQHAA-----------WIIPFFCYQIFDFALNTLVA 121
Cdd:TIGR00799  68 NALFIISVSLLMgvvknrekylypflslqimdFLLCLLTLLGSYIELPAylklarprpgpSKIPLMTLQLLDFCLSILTL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789653 122 ITVLVY--PNSIQEYIRQLPpSFPYRDDIMSVNPTCLVLVILLFIGIILTFKGYLISCVWSCYRYINGRNSsdVLVYVTS 199
Cdd:TIGR00799 148 CSSYMEvpTYLNFKSMNHMN-YLPSQEDLPHLQFICMMFIFSVAFITVLIFKVYMFKCVWNCYKYIKNMNS--IAEYPAS 224

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958789653 200 ND-TTVLLPPYDDATAV---TGTAKEPPPPYVSA 229
Cdd:TIGR00799 225 KMpPKVVLPSYEEALSLpekTPEGDPAPPPYSEV 258
Mtp pfam03821
Golgi 4-transmembrane spanning transporter;
161-226 4.95e-09

Golgi 4-transmembrane spanning transporter;


Pssm-ID: 461064  Cd Length: 229  Bit Score: 54.78  E-value: 4.95e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958789653 161 LLFIGIiLTFKGYLISCVWSCYRYINGRNSSDVLVyVTSNDTTVLLPPYDDATAVTGtaKEP-PPPY 226
Cdd:pfam03821 165 IAFIAV-LILKVYMFKCVWRCYKYIKAMNSGGVKV-DSKLLQKVVLPSYEEALSLPS--KEPaPPPY 227
 
Name Accession Description Interval E-value
mtp TIGR00799
Golgi 4-transmembrane spanning transporter; The proteins of the MET family have 4 TMS regions ...
 73-229 2.45e-23

Golgi 4-transmembrane spanning transporter; The proteins of the MET family have 4 TMS regions and are located in late endosomal or lysosomal membranes. Substrates of the mouse MTP transporter include thymidine, both nucleoside and nucleobase analogues, antibiotics, anthracyclines, ionophores and steroid hormones. MET transporters may be involved in the subcellular compartmentation of steroid hormones and other compounds.Drug sensitivity by mouse MET was regulated by compounds that inhibit lysosomal function, interface with intracellular cholesterol transport, or modulate the multidrug resistance phenotype of mammalian cells. Thus, MET family members may compartmentalize diverse hydrophobic molecules, thereby affecting cellular drug sensitivity,nucleoside/nucleobase availability and steroid hormone responses. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273274  Cd Length: 258  Bit Score: 94.28  E-value: 2.45e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789653  73 NMCIAIAISLLM--------------------ILICAMATYGAYKQHAA-----------WIIPFFCYQIFDFALNTLVA 121
Cdd:TIGR00799  68 NALFIISVSLLMgvvknrekylypflslqimdFLLCLLTLLGSYIELPAylklarprpgpSKIPLMTLQLLDFCLSILTL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789653 122 ITVLVY--PNSIQEYIRQLPpSFPYRDDIMSVNPTCLVLVILLFIGIILTFKGYLISCVWSCYRYINGRNSsdVLVYVTS 199
Cdd:TIGR00799 148 CSSYMEvpTYLNFKSMNHMN-YLPSQEDLPHLQFICMMFIFSVAFITVLIFKVYMFKCVWNCYKYIKNMNS--IAEYPAS 224

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958789653 200 ND-TTVLLPPYDDATAV---TGTAKEPPPPYVSA 229
Cdd:TIGR00799 225 KMpPKVVLPSYEEALSLpekTPEGDPAPPPYSEV 258
Mtp pfam03821
Golgi 4-transmembrane spanning transporter;
161-226 4.95e-09

Golgi 4-transmembrane spanning transporter;


Pssm-ID: 461064  Cd Length: 229  Bit Score: 54.78  E-value: 4.95e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958789653 161 LLFIGIiLTFKGYLISCVWSCYRYINGRNSSDVLVyVTSNDTTVLLPPYDDATAVTGtaKEP-PPPY 226
Cdd:pfam03821 165 IAFIAV-LILKVYMFKCVWRCYKYIKAMNSGGVKV-DSKLLQKVVLPSYEEALSLPS--KEPaPPPY 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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