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Conserved domains on  [gi|1958789512|ref|XP_038935089|]
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fibrocystin-L isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2183-2301 5.47e-40

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 145.44  E-value: 5.47e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 2183 SWGGKLPPEEGSLAVITKGQIILLDQSTPILKMLLIQGgTLIF-DEADIELQAENILITdGGVLQIGTEAFPFQHQAVIT 2261
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQG-TLIFdDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958789512 2262 LHG--HLRSPELPVYGAKTLAVRE-GTLDLHGLPIPVVWTRLA 2301
Cdd:pfam10162   79 LHGrpELDDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKLA 121
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 3042-3170 7.55e-38

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 139.28  E-value: 7.55e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 3042 NNYTVPRPGANVIIPEGTWIVADMDIPPMEKLIIWGVLEMEDKsevgaagpayRKVVLNATYISVQGGRLIGGWEDNPFK 3121
Cdd:pfam10162    3 GGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDD----------KNITLRARYILVQGGRLIIGSEDCPFQ 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958789512 3122 GELQIVLRGNhstPEWALPDGPNQGAKVLGV--FGELDLHGLPHSVYKTKL 3170
Cdd:pfam10162   73 GKATITLHGR---PELDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKL 120
Cupredoxin super family cl19115
Cupredoxin superfamily; Cupredoxins contain type I copper centers and are involved in ...
 1394-1497 4.69e-31

Cupredoxin superfamily; Cupredoxins contain type I copper centers and are involved in inter-molecular electron transfer reactions. Cupredoxins are blue copper proteins, having an intense blue color due to the presence of a mononuclear type 1 (T1) copper site. Structurally, the cupredoxin-like fold consists of a beta-sandwich with 7 strands in 2 beta-sheets, which is arranged in a Greek-key beta-barrel. Some of these proteins have lost the ability to bind copper. The majority of family members contain multiple cupredoxin domain repeats: ceruloplasmin and the coagulation factors V/VIII have six repeats; laccase, ascorbate oxidase, spore coat protein A, and multicopper oxidase CueO contain three repeats; and nitrite reductase has two repeats. Others are mono-domain cupredoxins, such as plastocyanin, pseudoazurin, plantacyanin, azurin, rusticyanin, stellacyanin, quinol oxidase, and the periplasmic domain of cytochrome c oxidase subunit II.


The actual alignment was detected with superfamily member cd04217:

Pssm-ID: 473140 [Multi-domain]  Cd Length: 86  Bit Score: 118.81  E-value: 4.69e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1394 TNNGSHLVHGLGYAWSPSVLNVTVGDTVVWYWRAHPflrgiGYRIFSVSSPGSVTYDgkgftngrQKSASGSFSYQFTSP 1473
Cdd:cd04217      1 TNAGKDLVRGLGYVISPSELEINVGDTVTWHNFKRP-----KGRIVLVSEEGLFEDQ--------TLYYGKAFSYTFTEP 67

                           90       100
                   ....*....|....*....|....
gi 1958789512 1474 GVHYYSSGYVDEthsisLQGVINV 1497
Cdd:cd04217     68 GTYYFSVKDVPE-----MKGTINV 86
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 2089-2174 3.41e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.12  E-value: 3.41e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 2089 PLIIEVSPRRGSTAGGTRLTVTGSGFSENTEDVQVTIANSKCDVQYSNKTHIVCMTSAHAPSGWAPVLVNIKNIGVAKLE 2168
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEVTVDGANVSARV 80


                   ....*...
gi 1958789512 2169 NAD--FLY 2174
Cdd:cd00603     81 LSNttFTY 88
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 271-363 3.61e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.12  E-value: 3.61e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  271 EVAMVSPSKGSPEGGTILTIHGQFFDQTDLPVRVLVGGQACDILNVTENTIYCKTPPKPHVLKATYPggrgLKIEVWNNS 350
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVE----VTVDGANVS 77

                           90
                   ....*....|...
gi 1958789512  351 RPTHLEDILEYSE 363
Cdd:cd00603     78 ARVLSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1240-1314 1.32e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 74.80  E-value: 1.32e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958789512 1240 PVVTDFSPKERTILGTVNLTIKGYNFGSELTQNTVYVGGKHCQILHSNFTDITCLLPTLP-PGKHEIYVKVRNWGL 1314
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtPGEGPVEVTVDGANV 76
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1829-1908 1.08e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 72.09  E-value: 1.08e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1829 PAVASVSPTSGSIAGGTTLMITGNGFSPG--NTTVTVGDQPCQIMFINSSEVHCSTPAGRAGTANLKIDVNSVIYPS--L 1904
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDssDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSspL 80


                   ....
gi 1958789512 1905 SFTY 1908
Cdd:pfam01833   81 TFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1657-1743 3.31e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 70.95  E-value: 3.31e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1657 PNIDLVMPKAGSTTGLTRVTIQGSGFMASSAGVEVFMGDFPCKVLNVTYTAIECETSPAP---HQLVLVDLLIHGVPAQC 1733
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtpgEGPVEVTVDGANVSARV 80

                           90
                   ....*....|
gi 1958789512 1734 QGNCSFSYLD 1743
Cdd:cd00603     81 LSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1157-1234 9.40e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 69.41  E-value: 9.40e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1157 ISHVWPDSGSLAGGTLLTISGFGF---SKNSTVLVGNETCNVIEGDLNRITCRTSKRIEG-----TVDISVITNGIQATS 1228
Cdd:cd00603      3 ITSISPSSGPLSGGTRLTITGSNLgsgSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPgegpvEVTVDGANVSARVLS 82


                   ....*.
gi 1958789512 1229 KDSFSY 1234
Cdd:cd00603     83 NTTFTY 88
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1998-2084 1.91e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 65.94  E-value: 1.91e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1998 SIQSISPRKGSFGGGQTLTVTGMGFDP--WNSTILVGGSECAVdkLLSNSTTLFCEIPPNNGKGP-DQACGVSVVNGKDS 2074
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSgsPRVRVTVGGVPCKV--LNVSSTEIVCRTPAAATPGEgPVEVTVDGANVSAR 79

                           90
                   ....*....|
gi 1958789512 2075 SQSVTLFTYM 2084
Cdd:cd00603     80 VLSNTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1914-1995 1.01e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 63.62  E-value: 1.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1914 PFLKSIIPNSGPP--GTEVEITGSNLGFAVSDVLVMIKESVCNVTTVNDTVLQCIVGEHAGGIFPVMMLHKTKGSAISSV 1991
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ....
gi 1958789512 1992 VFEY 1995
Cdd:pfam01833   81 TFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1564-1627 1.37e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 60.15  E-value: 1.37e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958789512 1564 PSIINITPSTGTAN--ELITITGHGFSNLTCANKVTIGSYPCVVEESNENSIMCHIDPQNSMDVGI 1627
Cdd:pfam01833    1 PVITSISPSSGPASggTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNV 66
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1329-1394 2.32e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 56.69  E-value: 2.32e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958789512 1329 LEVTHMFPQRGSLYGGTEITIIGSGFSTIPTENSVLLGSFPCDITSSSENVIKCTL-HSTGAVFRIT 1394
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTpPGTSGLVNVS 67
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 31-126 2.38e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 57.08  E-value: 2.38e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512   31 PKVTEVIPKYGSINGATRLTIKGEGFSQASqfnygadnielgnhVQLVSSFQSITCDVEkdSTHSTQITCYTRAMPEDV- 109
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGS--------------PRVRVTVGGVPCKVL--NVSSTEIVCRTPAAATPGe 64

                           90
                   ....*....|....*..
gi 1958789512  110 YSVRVSVDGVPVAENNT 126
Cdd:cd00603     65 GPVEVTVDGANVSARVL 81
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1747-1825 4.70e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.92  E-value: 4.70e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1747 PYVTGVFPNS--IQGSGSVLIIGEGFGTVLEEISIFIGIQKFRVLDVNENNITVLMTPLAAGLHSLSVVVGSKGLALGNL 1824
Cdd:pfam01833    1 PVITSISPSSgpASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   .
gi 1958789512 1825 S 1825
Cdd:pfam01833   81 T 81
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1067-1143 6.67e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.53  E-value: 6.67e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958789512 1067 PLILTTTPSEGSYAESTILTIAGSGFSPTS-AVSVSVGSTQCSLLSVEENEIKCQILNGSAGHVPVAVSIAGVGLAQN 1143
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
PA14 super family cl08459
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 371-467 4.60e-07

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


The actual alignment was detected with superfamily member pfam07691:

Pssm-ID: 471833 [Multi-domain]  Cd Length: 141  Bit Score: 51.98  E-value: 4.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  371 ASWTDSASYvwPIEQDTFVARISGFLVPPDSDVYRFYIRGDDRYAIYFSqtghpeDKVRIAYysrNANTYFSSSTQKSDE 450
Cdd:pfam07691   31 YWDTDVPGF--GEAPGDFSARWTGYLLPPESGTYTFGVASDDGARLWID------GELVIDN---WGQHPPDASPEESNT 99

                           90
                   ....*....|....*..
gi 1958789512  451 IHLQKGKEYYIEILLQE 467
Cdd:pfam07691  100 LYLVAGKLYPIRIEYFH 116
NosD super family cl34609
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 3254-3510 1.29e-05

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG3420:

Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 50.69  E-value: 1.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 3254 ILSRNIKIVGEDYSVwskdsfgariLVGSFTGNMMTFKG-NARISNVEFYHSGqegyRDSTDPRYAVTFLNlgqiqDHGL 3332
Cdd:COG3420     49 VIDKPLTLIGEGGAV----------IDGGGKGTVITITAdNVTVRGLTITGSG----DSLTDDDAGIYVRG-----ADNA 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 3333 SyVRGCAFHHGFSpAIGVFGTNGVDIDDNIIY------FTVGEGIRIWG-DANRVRGNLVTlsvwpgtyQNRkDlsstlw 3405
Cdd:COG3420    110 V-IENNRIENNLF-GIYLEGSDNNVIRNNTISgnrdlrADRGNGIHLWNsPGNVIEGNTIS--------GGR-D------ 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 3406 haAIEINRGTNTVLQNNIVAGfGRVGYRIDgepcSSQANpmeNWFNNEAHGGLYGIY-MNQDGLpgcsLIQGFTIWACWD 3484
Cdd:COG3420    173 --GIYLEFSDNNVIRNNTIRN-LRYGIHYM----YSNDN---LVEGNTFRDNGAGIAlMYSKGN----TVRGNTILGNSG 238

                          250       260
                   ....*....|....*....|....*.
gi 1958789512 3485 YGIYFQTMESVHIYNVTLVNNGMAIF 3510
Cdd:COG3420    239 YGILLKESSDSVIEGNTISGNGKGIF 264
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 146-255 4.44e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 41.66  E-value: 4.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  146 PTIRSITPLSGTP--GTLITIQGRLFtdvygsntalssnGRNVRILRTYIGGMPCELLiphsddlyglkldhpSRDTGSV 223
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNF-------------GTDSSDLKVTIGGTPCTVI---------------SVSSTTI 52

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1958789512  224 TCKATGTYIGHHNVSFILDSDYGRSFPENTTY 255
Cdd:pfam01833   53 VCTTPPGTSGLVNVSVTVGGGGISSSPLTFTY 84
 
Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2183-2301 5.47e-40

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 145.44  E-value: 5.47e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 2183 SWGGKLPPEEGSLAVITKGQIILLDQSTPILKMLLIQGgTLIF-DEADIELQAENILITdGGVLQIGTEAFPFQHQAVIT 2261
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQG-TLIFdDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958789512 2262 LHG--HLRSPELPVYGAKTLAVRE-GTLDLHGLPIPVVWTRLA 2301
Cdd:pfam10162   79 LHGrpELDDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKLA 121
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 3042-3170 7.55e-38

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 139.28  E-value: 7.55e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 3042 NNYTVPRPGANVIIPEGTWIVADMDIPPMEKLIIWGVLEMEDKsevgaagpayRKVVLNATYISVQGGRLIGGWEDNPFK 3121
Cdd:pfam10162    3 GGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDD----------KNITLRARYILVQGGRLIIGSEDCPFQ 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958789512 3122 GELQIVLRGNhstPEWALPDGPNQGAKVLGV--FGELDLHGLPHSVYKTKL 3170
Cdd:pfam10162   73 GKATITLHGR---PELDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKL 120
Cupredoxin_Fibrocystin-L_like cd04217
Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease ...
 1394-1497 4.69e-31

Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease protein; One member of this family is Fibrocystin-L, a homolog of the autosomal recessive polycystic kidney disease protein PKHD1. Human fibrocystin-L is predicted to be a large receptor protein (466 kDa) with a signal peptide, a single transmembrane domain and a short cytoplasmic tail. Fibrocystin-L is widely expressed at a low level in most tissues but is up-regulated specifically in T lymphocytes following activation signals. It may play roles in immunity.


Pssm-ID: 259879 [Multi-domain]  Cd Length: 86  Bit Score: 118.81  E-value: 4.69e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1394 TNNGSHLVHGLGYAWSPSVLNVTVGDTVVWYWRAHPflrgiGYRIFSVSSPGSVTYDgkgftngrQKSASGSFSYQFTSP 1473
Cdd:cd04217      1 TNAGKDLVRGLGYVISPSELEINVGDTVTWHNFKRP-----KGRIVLVSEEGLFEDQ--------TLYYGKAFSYTFTEP 67

                           90       100
                   ....*....|....*....|....
gi 1958789512 1474 GVHYYSSGYVDEthsisLQGVINV 1497
Cdd:cd04217     68 GTYYFSVKDVPE-----MKGTINV 86
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 2089-2174 3.41e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.12  E-value: 3.41e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 2089 PLIIEVSPRRGSTAGGTRLTVTGSGFSENTEDVQVTIANSKCDVQYSNKTHIVCMTSAHAPSGWAPVLVNIKNIGVAKLE 2168
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEVTVDGANVSARV 80


                   ....*...
gi 1958789512 2169 NAD--FLY 2174
Cdd:cd00603     81 LSNttFTY 88
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 271-363 3.61e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.12  E-value: 3.61e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  271 EVAMVSPSKGSPEGGTILTIHGQFFDQTDLPVRVLVGGQACDILNVTENTIYCKTPPKPHVLKATYPggrgLKIEVWNNS 350
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVE----VTVDGANVS 77

                           90
                   ....*....|...
gi 1958789512  351 RPTHLEDILEYSE 363
Cdd:cd00603     78 ARVLSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1240-1314 1.32e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 74.80  E-value: 1.32e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958789512 1240 PVVTDFSPKERTILGTVNLTIKGYNFGSELTQNTVYVGGKHCQILHSNFTDITCLLPTLP-PGKHEIYVKVRNWGL 1314
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtPGEGPVEVTVDGANV 76
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1829-1908 1.08e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 72.09  E-value: 1.08e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1829 PAVASVSPTSGSIAGGTTLMITGNGFSPG--NTTVTVGDQPCQIMFINSSEVHCSTPAGRAGTANLKIDVNSVIYPS--L 1904
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDssDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSspL 80


                   ....
gi 1958789512 1905 SFTY 1908
Cdd:pfam01833   81 TFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1657-1743 3.31e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 70.95  E-value: 3.31e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1657 PNIDLVMPKAGSTTGLTRVTIQGSGFMASSAGVEVFMGDFPCKVLNVTYTAIECETSPAP---HQLVLVDLLIHGVPAQC 1733
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtpgEGPVEVTVDGANVSARV 80

                           90
                   ....*....|
gi 1958789512 1734 QGNCSFSYLD 1743
Cdd:cd00603     81 LSNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 2089-2163 5.29e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 70.17  E-value: 5.29e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958789512 2089 PLIIEVSPRRGSTAGGTRLTVTGSGFSENTEDVQVTIANSKCDVQYSNKTHIVCMTSAHaPSGWAPVLVNIKNIG 2163
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPG-TSGLVNVSVTVGGGG 74
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1157-1234 9.40e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 69.41  E-value: 9.40e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1157 ISHVWPDSGSLAGGTLLTISGFGF---SKNSTVLVGNETCNVIEGDLNRITCRTSKRIEG-----TVDISVITNGIQATS 1228
Cdd:cd00603      3 ITSISPSSGPLSGGTRLTITGSNLgsgSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPgegpvEVTVDGANVSARVLS 82


                   ....*.
gi 1958789512 1229 KDSFSY 1234
Cdd:cd00603     83 NTTFTY 88
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1829-1908 1.10e-13

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 69.41  E-value: 1.10e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1829 PAVASVSPTSGSIAGGTTLMITGNGFSPG--NTTVTVGDQPCQIMFINSSEVHCSTPA---GRAGTANLKIDVNSVIYPS 1903
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGspRVRVTVGGVPCKVLNVSSTEIVCRTPAaatPGEGPVEVTVDGANVSARV 80


                   ....*...
gi 1958789512 1904 LS---FTY 1908
Cdd:cd00603     81 LSnttFTY 88
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1998-2084 1.91e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 65.94  E-value: 1.91e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1998 SIQSISPRKGSFGGGQTLTVTGMGFDP--WNSTILVGGSECAVdkLLSNSTTLFCEIPPNNGKGP-DQACGVSVVNGKDS 2074
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSgsPRVRVTVGGVPCKV--LNVSSTEIVCRTPAAATPGEgPVEVTVDGANVSAR 79

                           90
                   ....*....|
gi 1958789512 2075 SQSVTLFTYM 2084
Cdd:cd00603     80 VLSNTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1914-1995 1.01e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 63.62  E-value: 1.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1914 PFLKSIIPNSGPP--GTEVEITGSNLGFAVSDVLVMIKESVCNVTTVNDTVLQCIVGEHAGGIFPVMMLHKTKGSAISSV 1991
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ....
gi 1958789512 1992 VFEY 1995
Cdd:pfam01833   81 TFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1998-2083 1.03e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 63.62  E-value: 1.03e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1998 SIQSISPRKGSFGGGQTLTVTGMGF--DPWNSTILVGGSECAVdkLLSNSTTLFCEIPPnngkGPDQACGVSV-VNGKDS 2074
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSNFgtDSSDLKVTIGGTPCTV--ISVSSTTIVCTTPP----GTSGLVNVSVtVGGGGI 75


                   ....*....
gi 1958789512 2075 SQSVTLFTY 2083
Cdd:pfam01833   76 SSSPLTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1564-1627 1.37e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 60.15  E-value: 1.37e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958789512 1564 PSIINITPSTGTAN--ELITITGHGFSNLTCANKVTIGSYPCVVEESNENSIMCHIDPQNSMDVGI 1627
Cdd:pfam01833    1 PVITSISPSSGPASggTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNV 66
IPT smart00429
ig-like, plexins, transcription factors;
275-337 1.82e-10

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 60.13  E-value: 1.82e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958789512   275 VSPSKGSPEGGTILTIHGQFFDQ-TDLPVRVLVGGQACDILNVTENTIYCKTPPKpHVLKATYP 337
Cdd:smart00429    7 ISPTSGPVSGGTEITLCGKNLKSiSVVFVEVGVGEAPCTFSPSSSTAIVCKTPPY-HNIPGSVP 69
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1914-1995 2.22e-10

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 59.78  E-value: 2.22e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1914 PFLKSIIPNSGPP--GTEVEITGSNLGFAVSDVLVMIKESVCNVTTVNDTVLQCIVGEHA-GGIFPVMMLHKTKG---SA 1987
Cdd:cd00603      1 PVITSISPSSGPLsgGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtPGEGPVEVTVDGANvsaRV 80


                   ....*...
gi 1958789512 1988 ISSVVFEY 1995
Cdd:cd00603     81 LSNTTFTY 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1657-1741 2.37e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 2.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1657 PNIDLVMPKAGSTTGLTRVTIQGSGFMASSAGVEVFMGDFPCKVLNVTYTAIECETSPAPHQLVLVDLLIHGVpAQCQGN 1736
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGG-GISSSP 79


                   ....*
gi 1958789512 1737 CSFSY 1741
Cdd:pfam01833   80 LTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 275-327 5.07e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 58.61  E-value: 5.07e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958789512  275 VSPSKGSPEGGTILTIHGQFFDQTDLPVRVLVGGQACDILNVTENTIYCKTPP 327
Cdd:pfam01833    6 ISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPP 58
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1156-1234 1.29e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.46  E-value: 1.29e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1156 QISHVWPDSGSLAGGTLLTISGFGFSKNS---TVLVGNETCNVIEGDLNRITCRTSKRIEGTVDISVITNGIQATSKD-S 1231
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSNFGTDSsdlKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPlT 81


                   ...
gi 1958789512 1232 FSY 1234
Cdd:pfam01833   82 FTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1240-1317 1.48e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.46  E-value: 1.48e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958789512 1240 PVVTDFSPKERTILGTVNLTIKGYNFGSELTQNTVYVGGKHCQILHSNFTDITCLLPTLPPGKHEIYVKVRNWGLAST 1317
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1329-1394 2.32e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 56.69  E-value: 2.32e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958789512 1329 LEVTHMFPQRGSLYGGTEITIIGSGFSTIPTENSVLLGSFPCDITSSSENVIKCTL-HSTGAVFRIT 1394
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTpPGTSGLVNVS 67
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 31-126 2.38e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 57.08  E-value: 2.38e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512   31 PKVTEVIPKYGSINGATRLTIKGEGFSQASqfnygadnielgnhVQLVSSFQSITCDVEkdSTHSTQITCYTRAMPEDV- 109
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGS--------------PRVRVTVGGVPCKVL--NVSSTEIVCRTPAAATPGe 64

                           90
                   ....*....|....*..
gi 1958789512  110 YSVRVSVDGVPVAENNT 126
Cdd:cd00603     65 GPVEVTVDGANVSARVL 81
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1747-1825 4.70e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.92  E-value: 4.70e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1747 PYVTGVFPNS--IQGSGSVLIIGEGFGTVLEEISIFIGIQKFRVLDVNENNITVLMTPLAAGLHSLSVVVGSKGLALGNL 1824
Cdd:pfam01833    1 PVITSISPSSgpASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   .
gi 1958789512 1825 S 1825
Cdd:pfam01833   81 T 81
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1067-1143 6.67e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.53  E-value: 6.67e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958789512 1067 PLILTTTPSEGSYAESTILTIAGSGFSPTS-AVSVSVGSTQCSLLSVEENEIKCQILNGSAGHVPVAVSIAGVGLAQN 1143
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1330-1384 1.45e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 54.77  E-value: 1.45e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958789512 1330 EVTHMFPQRGSLYGGTEITIIGSGFSTIPTENSVLLGSFPCDITSSSENVIKCTL 1384
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRT 56
IPT smart00429
ig-like, plexins, transcription factors;
2089-2174 2.53e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 53.96  E-value: 2.53e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  2089 PLIIEVSPRRGSTAGGTRLTVTGSGF-SENTEDVQVTIANSKCDVQYSNKTHIVCMTSAHAPSgwaPVLVNIKNIGV--- 2164
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLkSISVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNI---PGSVPVRTVGLrng 78

                            90
                    ....*....|.
gi 1958789512  2165 -AKLENADFLY 2174
Cdd:smart00429   79 gVPSSPQPFTY 89
IPT smart00429
ig-like, plexins, transcription factors;
1829-1908 6.92e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 52.81  E-value: 6.92e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  1829 PAVASVSPTSGSIAGGTTLMITGNGFSPGNT---TVTVGDQPCQIMFINSSEVHCSTPAGRAGTANLKIDVNS-----VI 1900
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVvfvEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGlrnggVP 81


                    ....*...
gi 1958789512  1901 YPSLSFTY 1908
Cdd:smart00429   82 SSPQPFTY 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1067-1154 2.27e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 51.30  E-value: 2.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1067 PLILTTTPSEGSYAESTILTIAGSGFSPTSA-VSVSVGSTQCSLLSVEENEIKCQIL-NGSAGHVPVAVSIaGVGLAQNL 1144
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrVRVTVGGVPCKVLNVSSTEIVCRTPaAATPGEGPVEVTV-DGANVSAR 79

                           90
                   ....*....|
gi 1958789512 1145 EGEGSHFVYQ 1154
Cdd:cd00603     80 VLSNTTFTYV 89
IPT smart00429
ig-like, plexins, transcription factors;
1998-2084 3.27e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 50.88  E-value: 3.27e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  1998 SIQSISPRKGSFGGGQTLTVTGMGFDPWNS---TILVGGSECAVdkLLSNSTTLFCEIPP-NNGKGPDQACGVSVVNGKD 2073
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSISVvfvEVGVGEAPCTF--SPSSSTAIVCKTPPyHNIPGSVPVRTVGLRNGGV 80

                            90
                    ....*....|.
gi 1958789512  2074 SSQSVTlFTYM 2084
Cdd:smart00429   81 PSSPQP-FTYV 90
PA14 pfam07691
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 371-467 4.60e-07

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


Pssm-ID: 400161 [Multi-domain]  Cd Length: 141  Bit Score: 51.98  E-value: 4.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  371 ASWTDSASYvwPIEQDTFVARISGFLVPPDSDVYRFYIRGDDRYAIYFSqtghpeDKVRIAYysrNANTYFSSSTQKSDE 450
Cdd:pfam07691   31 YWDTDVPGF--GEAPGDFSARWTGYLLPPESGTYTFGVASDDGARLWID------GELVIDN---WGQHPPDASPEESNT 99

                           90
                   ....*....|....*..
gi 1958789512  451 IHLQKGKEYYIEILLQE 467
Cdd:pfam07691  100 LYLVAGKLYPIRIEYFH 116
PA14 smart00758
domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, ...
 372-467 5.63e-06

domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins;


Pssm-ID: 214807 [Multi-domain]  Cd Length: 136  Bit Score: 48.94  E-value: 5.63e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512   372 SWTDSASYvwPIEQDTFVARISGFLVPPDSDVYRFYIRGDDRYAIYFSqtghpeDKVRIayySRNANTYFSSSTqkSDEI 451
Cdd:smart00758   30 WDSDKFGE--GEKADNFSVRWTGYLKPPEDGEYTFSITSDDGARLWID------GKLVI---DNWGKHEARPST--SSTL 96

                            90
                    ....*....|....*.
gi 1958789512   452 HLQKGKEYYIEILLQE 467
Cdd:smart00758   97 YLLAGGTYPIRIEYFE 112
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 3254-3510 1.29e-05

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 50.69  E-value: 1.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 3254 ILSRNIKIVGEDYSVwskdsfgariLVGSFTGNMMTFKG-NARISNVEFYHSGqegyRDSTDPRYAVTFLNlgqiqDHGL 3332
Cdd:COG3420     49 VIDKPLTLIGEGGAV----------IDGGGKGTVITITAdNVTVRGLTITGSG----DSLTDDDAGIYVRG-----ADNA 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 3333 SyVRGCAFHHGFSpAIGVFGTNGVDIDDNIIY------FTVGEGIRIWG-DANRVRGNLVTlsvwpgtyQNRkDlsstlw 3405
Cdd:COG3420    110 V-IENNRIENNLF-GIYLEGSDNNVIRNNTISgnrdlrADRGNGIHLWNsPGNVIEGNTIS--------GGR-D------ 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 3406 haAIEINRGTNTVLQNNIVAGfGRVGYRIDgepcSSQANpmeNWFNNEAHGGLYGIY-MNQDGLpgcsLIQGFTIWACWD 3484
Cdd:COG3420    173 --GIYLEFSDNNVIRNNTIRN-LRYGIHYM----YSNDN---LVEGNTFRDNGAGIAlMYSKGN----TVRGNTILGNSG 238

                          250       260
                   ....*....|....*....|....*.
gi 1958789512 3485 YGIYFQTMESVHIYNVTLVNNGMAIF 3510
Cdd:COG3420    239 YGILLKESSDSVIEGNTISGNGKGIF 264
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 31-126 1.63e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 45.90  E-value: 1.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512   31 PKVTEVIPKYGSINGATRLTIKGEGFSQASqfnygaDNIELgnhvqlvsSFQSITCDVEKDSthSTQITCYTRAMPEDVY 110
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDS------SDLKV--------TIGGTPCTVISVS--STTIVCTTPPGTSGLV 64

                           90
                   ....*....|....*.
gi 1958789512  111 SVRVSVDGVPVAENNT 126
Cdd:pfam01833   65 NVSVTVGGGGISSSPL 80
IPT smart00429
ig-like, plexins, transcription factors;
1329-1384 6.31e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 44.33  E-value: 6.31e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958789512  1329 LEVTHMFPQRGSLYGGTEITIIGSGFSTIPTEN-SVLLGSFPCDITSSSENVIKCTL 1384
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFvEVGVGEAPCTFSPSSSTAIVCKT 58
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1564-1622 6.54e-05

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 44.37  E-value: 6.54e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958789512 1564 PSIINITPSTGTANE--LITITGHGFSNLTCANKVTIGSYPCVVEESNENSIMCHIDPQNS 1622
Cdd:cd00603      1 PVITSISPSSGPLSGgtRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAT 61
IPT smart00429
ig-like, plexins, transcription factors;
1157-1234 7.67e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 44.33  E-value: 7.67e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  1157 ISHVWPDSGSLAGGTLLTISGFGF----SKNSTVLVGNETCNVIEGDLNRITCRTSKRIEGTVDISVITNGIQ----ATS 1228
Cdd:smart00429    4 ITRISPTSGPVSGGTEITLCGKNLksisVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRnggvPSS 83


                    ....*.
gi 1958789512  1229 KDSFSY 1234
Cdd:smart00429   84 PQPFTY 89
IPT smart00429
ig-like, plexins, transcription factors;
1067-1153 8.80e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 43.95  E-value: 8.80e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  1067 PLILTTTPSEGSYAESTILTIAGSGFSPTSAVSVSV--GSTQCSLLSVEENEIKCQILNGSAGHVPVAVSIAGVGLAqNL 1144
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVgvGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRNG-GV 80


                    ....*....
gi 1958789512  1145 EGEGSHFVY 1153
Cdd:smart00429   81 PSSPQPFTY 89
IPT smart00429
ig-like, plexins, transcription factors;
1656-1742 1.01e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 43.95  E-value: 1.01e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  1656 LPNIDLVMPKAGSTTGLTRVTIQGSGFMASSAGVEVFMGDF-PCKVLNVTYTAIECETSPAPHQLVL-----VDLLIHGV 1729
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEaPCTFSPSSSTAIVCKTPPYHNIPGSvpvrtVGLRNGGV 80

                            90
                    ....*....|...
gi 1958789512  1730 PAQCQgncSFSYL 1742
Cdd:smart00429   81 PSSPQ---PFTYV 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 146-255 4.44e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 41.66  E-value: 4.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  146 PTIRSITPLSGTP--GTLITIQGRLFtdvygsntalssnGRNVRILRTYIGGMPCELLiphsddlyglkldhpSRDTGSV 223
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNF-------------GTDSSDLKVTIGGTPCTVI---------------SVSSTTI 52

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1958789512  224 TCKATGTYIGHHNVSFILDSDYGRSFPENTTY 255
Cdd:pfam01833   53 VCTTPPGTSGLVNVSVTVGGGGISSSPLTFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 146-256 7.74e-04

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 41.29  E-value: 7.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  146 PTIRSITPLSGTP--GTLITIqgrlftdvYGSNtaLSSNGRNVRIlrtYIGGMPCELLiphsddlyglkldhpSRDTGSV 223
Cdd:cd00603      1 PVITSISPSSGPLsgGTRLTI--------TGSN--LGSGSPRVRV---TVGGVPCKVL---------------NVSSTEI 52

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1958789512  224 TCKA-TGTYIGHHNVSFILDSDYGRSFPENTTYF 256
Cdd:cd00603     53 VCRTpAAATPGEGPVEVTVDGANVSARVLSNTTF 86
PetE COG3794
Plastocyanin [Energy production and conversion];
1406-1498 8.66e-04

Plastocyanin [Energy production and conversion];


Pssm-ID: 443008 [Multi-domain]  Cd Length: 76  Bit Score: 40.75  E-value: 8.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1406 YAWSPSVLNVTVGDTVVWYWRAhpflrGIGYRIFSVSSPgsvtydGKGFTNGRQKsASGSFSYQFTSPGVHYyssgYVDE 1485
Cdd:COG3794      1 MAFEPATLTVKPGDTVTWVNTD-----SVPHNVTSDDGP------DGAFDSGLLA-PGETFSVTFDEPGTYD----YYCT 64

                           90
                   ....*....|...
gi 1958789512 1486 THSiSLQGVINVV 1498
Cdd:COG3794     65 PHP-WMVGTIVVG 76
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 3326-3505 9.37e-04

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 42.78  E-value: 9.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 3326 QIQDHGLSYVRGCAFHHGFSPAIGVFGTNGVDIDDNIIYFTVGEGIRIWGDAN-RVRGNLVTLSvwpgtyqnrkdlsstl 3404
Cdd:pfam13229    4 LLNGSSNATIKNNTISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNnTISNNTISNN---------------- 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 3405 WHAAIEINRGTNTVLQNNIVAGFGRVGYRIDGepcSSQANPMENWFNNeahGGLYGIYMNQDGLPGcsLIQGFTIWACWD 3484
Cdd:pfam13229   68 GGGGIALRGSSNNLIENNTISNNGGAGIYLSD---SSNNTIENNIIHN---NGGSGIVIEDSSNNV--TISNNTVTNNKG 139

                          170       180
                   ....*....|....*....|.
gi 1958789512 3485 YGIYFQTmesvHIYNVTLVNN 3505
Cdd:pfam13229  140 AGILIVG----GSSNNTVENN 156
IPT smart00429
ig-like, plexins, transcription factors;
31-119 1.70e-03

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.48  E-value: 1.70e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512    31 PKVTEVIPKYGSINGATRLTIKGEGFSQASQFNYGADNIElgnhvqlvssfqsITCDVekDSTHSTQITCYTRAMPEDVY 110
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGE-------------APCTF--SPSSSTAIVCKTPPYHNIPG 66


                    ....*....
gi 1958789512   111 SVRVSVDGV 119
Cdd:smart00429   67 SVPVRTVGL 75
IPT smart00429
ig-like, plexins, transcription factors;
1918-1977 2.15e-03

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.10  E-value: 2.15e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958789512  1918 SIIPNSGPP--GTEVEITGSNLG-FAVSDVLVMIKESVCNVTTVNDTVLQCIVGEHAGGIFPV 1977
Cdd:smart00429    6 RISPTSGPVsgGTEITLCGKNLKsISVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSV 68
 
Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2183-2301 5.47e-40

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 145.44  E-value: 5.47e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 2183 SWGGKLPPEEGSLAVITKGQIILLDQSTPILKMLLIQGgTLIF-DEADIELQAENILITdGGVLQIGTEAFPFQHQAVIT 2261
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQG-TLIFdDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958789512 2262 LHG--HLRSPELPVYGAKTLAVRE-GTLDLHGLPIPVVWTRLA 2301
Cdd:pfam10162   79 LHGrpELDDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKLA 121
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 3042-3170 7.55e-38

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 139.28  E-value: 7.55e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 3042 NNYTVPRPGANVIIPEGTWIVADMDIPPMEKLIIWGVLEMEDKsevgaagpayRKVVLNATYISVQGGRLIGGWEDNPFK 3121
Cdd:pfam10162    3 GGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDD----------KNITLRARYILVQGGRLIIGSEDCPFQ 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958789512 3122 GELQIVLRGNhstPEWALPDGPNQGAKVLGV--FGELDLHGLPHSVYKTKL 3170
Cdd:pfam10162   73 GKATITLHGR---PELDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKL 120
Cupredoxin_Fibrocystin-L_like cd04217
Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease ...
 1394-1497 4.69e-31

Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease protein; One member of this family is Fibrocystin-L, a homolog of the autosomal recessive polycystic kidney disease protein PKHD1. Human fibrocystin-L is predicted to be a large receptor protein (466 kDa) with a signal peptide, a single transmembrane domain and a short cytoplasmic tail. Fibrocystin-L is widely expressed at a low level in most tissues but is up-regulated specifically in T lymphocytes following activation signals. It may play roles in immunity.


Pssm-ID: 259879 [Multi-domain]  Cd Length: 86  Bit Score: 118.81  E-value: 4.69e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1394 TNNGSHLVHGLGYAWSPSVLNVTVGDTVVWYWRAHPflrgiGYRIFSVSSPGSVTYDgkgftngrQKSASGSFSYQFTSP 1473
Cdd:cd04217      1 TNAGKDLVRGLGYVISPSELEINVGDTVTWHNFKRP-----KGRIVLVSEEGLFEDQ--------TLYYGKAFSYTFTEP 67

                           90       100
                   ....*....|....*....|....
gi 1958789512 1474 GVHYYSSGYVDEthsisLQGVINV 1497
Cdd:cd04217     68 GTYYFSVKDVPE-----MKGTINV 86
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 2089-2174 3.41e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.12  E-value: 3.41e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 2089 PLIIEVSPRRGSTAGGTRLTVTGSGFSENTEDVQVTIANSKCDVQYSNKTHIVCMTSAHAPSGWAPVLVNIKNIGVAKLE 2168
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEVTVDGANVSARV 80


                   ....*...
gi 1958789512 2169 NAD--FLY 2174
Cdd:cd00603     81 LSNttFTY 88
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 271-363 3.61e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.12  E-value: 3.61e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  271 EVAMVSPSKGSPEGGTILTIHGQFFDQTDLPVRVLVGGQACDILNVTENTIYCKTPPKPHVLKATYPggrgLKIEVWNNS 350
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVE----VTVDGANVS 77

                           90
                   ....*....|...
gi 1958789512  351 RPTHLEDILEYSE 363
Cdd:cd00603     78 ARVLSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1240-1314 1.32e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 74.80  E-value: 1.32e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958789512 1240 PVVTDFSPKERTILGTVNLTIKGYNFGSELTQNTVYVGGKHCQILHSNFTDITCLLPTLP-PGKHEIYVKVRNWGL 1314
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtPGEGPVEVTVDGANV 76
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1829-1908 1.08e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 72.09  E-value: 1.08e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1829 PAVASVSPTSGSIAGGTTLMITGNGFSPG--NTTVTVGDQPCQIMFINSSEVHCSTPAGRAGTANLKIDVNSVIYPS--L 1904
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDssDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSspL 80


                   ....
gi 1958789512 1905 SFTY 1908
Cdd:pfam01833   81 TFTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 2089-2174 1.40e-14

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 71.72  E-value: 1.40e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 2089 PLIIEVSPRRGSTAGGTRLTVTGSGFSeNTEDVQVTI-ANSKCDVQYSNKTHIVCMTSAHAPSGWAPVLVNIKNIGVAKL 2167
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFG-SGSNLRVTFgGGVPCSVLSVSSTAIVCTTPPYANPGPGPVEVTVDRGNGGIT 79


                   ....*...
gi 1958789512 2168 ENA-DFLY 2174
Cdd:cd00102     80 SSPlTFTY 87
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1657-1743 3.31e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 70.95  E-value: 3.31e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1657 PNIDLVMPKAGSTTGLTRVTIQGSGFMASSAGVEVFMGDFPCKVLNVTYTAIECETSPAP---HQLVLVDLLIHGVPAQC 1733
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtpgEGPVEVTVDGANVSARV 80

                           90
                   ....*....|
gi 1958789512 1734 QGNCSFSYLD 1743
Cdd:cd00603     81 LSNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 2089-2163 5.29e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 70.17  E-value: 5.29e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958789512 2089 PLIIEVSPRRGSTAGGTRLTVTGSGFSENTEDVQVTIANSKCDVQYSNKTHIVCMTSAHaPSGWAPVLVNIKNIG 2163
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPG-TSGLVNVSVTVGGGG 74
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1157-1234 9.40e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 69.41  E-value: 9.40e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1157 ISHVWPDSGSLAGGTLLTISGFGF---SKNSTVLVGNETCNVIEGDLNRITCRTSKRIEG-----TVDISVITNGIQATS 1228
Cdd:cd00603      3 ITSISPSSGPLSGGTRLTITGSNLgsgSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPgegpvEVTVDGANVSARVLS 82


                   ....*.
gi 1958789512 1229 KDSFSY 1234
Cdd:cd00603     83 NTTFTY 88
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1829-1908 1.10e-13

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 69.41  E-value: 1.10e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1829 PAVASVSPTSGSIAGGTTLMITGNGFSPG--NTTVTVGDQPCQIMFINSSEVHCSTPA---GRAGTANLKIDVNSVIYPS 1903
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGspRVRVTVGGVPCKVLNVSSTEIVCRTPAaatPGEGPVEVTVDGANVSARV 80


                   ....*...
gi 1958789512 1904 LS---FTY 1908
Cdd:cd00603     81 LSnttFTY 88
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1829-1908 1.48e-13

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 68.79  E-value: 1.48e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1829 PAVASVSPTSGSIAGGTTLMITGNGFSPGNTT-VTVGDQPCQIMFINSSEVHCSTPAGRA-GTANLKIDVNSVIY-PSLS 1905
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVrVTVGGQPCKILSVSSSQIVCLTPPSASpGEAPVKVLIDGARRlAPLV 80


                   ...
gi 1958789512 1906 FTY 1908
Cdd:cd01179     81 FTY 83
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1998-2084 1.91e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 65.94  E-value: 1.91e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1998 SIQSISPRKGSFGGGQTLTVTGMGFDP--WNSTILVGGSECAVdkLLSNSTTLFCEIPPNNGKGP-DQACGVSVVNGKDS 2074
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSgsPRVRVTVGGVPCKV--LNVSSTEIVCRTPAAATPGEgPVEVTVDGANVSAR 79

                           90
                   ....*....|
gi 1958789512 2075 SQSVTLFTYM 2084
Cdd:cd00603     80 VLSNTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1914-1995 1.01e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 63.62  E-value: 1.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1914 PFLKSIIPNSGPP--GTEVEITGSNLGFAVSDVLVMIKESVCNVTTVNDTVLQCIVGEHAGGIFPVMMLHKTKGSAISSV 1991
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ....
gi 1958789512 1992 VFEY 1995
Cdd:pfam01833   81 TFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1998-2083 1.03e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 63.62  E-value: 1.03e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1998 SIQSISPRKGSFGGGQTLTVTGMGF--DPWNSTILVGGSECAVdkLLSNSTTLFCEIPPnngkGPDQACGVSV-VNGKDS 2074
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSNFgtDSSDLKVTIGGTPCTV--ISVSSTTIVCTTPP----GTSGLVNVSVtVGGGGI 75


                   ....*....
gi 1958789512 2075 SQSVTLFTY 2083
Cdd:pfam01833   76 SSSPLTFTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1156-1234 1.59e-11

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 63.25  E-value: 1.59e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1156 QISHVWPDSGSLAGGTLLTISG--FGFSKNSTVLV-GNETCNVIEGDLNRITCRTSK---RIEGTVDISVIT-NGIQATS 1228
Cdd:cd00102      2 VITSISPSSGPVSGGTEVTITGsnFGSGSNLRVTFgGGVPCSVLSVSSTAIVCTTPPyanPGPGPVEVTVDRgNGGITSS 81


                   ....*.
gi 1958789512 1229 KDSFSY 1234
Cdd:cd00102     82 PLTFTY 87
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 275-329 2.47e-11

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 62.48  E-value: 2.47e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958789512  275 VSPSKGSPEGGTILTIHGQFFDqTDLPVRVLVGG-QACDILNVTENTIYCKTPPKP 329
Cdd:cd00102      6 ISPSSGPVSGGTEVTITGSNFG-SGSNLRVTFGGgVPCSVLSVSSTAIVCTTPPYA 60
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1829-1908 7.51e-11

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 61.32  E-value: 7.51e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1829 PAVASVSPTSGSIAGGTTLMITGNGFSPG-NTTVTV-GDQPCQIMFINSSEVHCSTPAGR---AGTANLKIDVNSVIY-- 1901
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGsNLRVTFgGGVPCSVLSVSSTAIVCTTPPYAnpgPGPVEVTVDRGNGGIts 80


                   ....*..
gi 1958789512 1902 PSLSFTY 1908
Cdd:cd00102     81 SPLTFTY 87
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1564-1627 1.37e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 60.15  E-value: 1.37e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958789512 1564 PSIINITPSTGTAN--ELITITGHGFSNLTCANKVTIGSYPCVVEESNENSIMCHIDPQNSMDVGI 1627
Cdd:pfam01833    1 PVITSISPSSGPASggTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNV 66
IPT smart00429
ig-like, plexins, transcription factors;
275-337 1.82e-10

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 60.13  E-value: 1.82e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958789512   275 VSPSKGSPEGGTILTIHGQFFDQ-TDLPVRVLVGGQACDILNVTENTIYCKTPPKpHVLKATYP 337
Cdd:smart00429    7 ISPTSGPVSGGTEITLCGKNLKSiSVVFVEVGVGEAPCTFSPSSSTAIVCKTPPY-HNIPGSVP 69
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1914-1995 2.22e-10

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 59.78  E-value: 2.22e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1914 PFLKSIIPNSGPP--GTEVEITGSNLGFAVSDVLVMIKESVCNVTTVNDTVLQCIVGEHA-GGIFPVMMLHKTKG---SA 1987
Cdd:cd00603      1 PVITSISPSSGPLsgGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtPGEGPVEVTVDGANvsaRV 80


                   ....*...
gi 1958789512 1988 ISSVVFEY 1995
Cdd:cd00603     81 LSNTTFTY 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1657-1741 2.37e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 2.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1657 PNIDLVMPKAGSTTGLTRVTIQGSGFMASSAGVEVFMGDFPCKVLNVTYTAIECETSPAPHQLVLVDLLIHGVpAQCQGN 1736
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGG-GISSSP 79


                   ....*
gi 1958789512 1737 CSFSY 1741
Cdd:pfam01833   80 LTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 275-327 5.07e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 58.61  E-value: 5.07e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958789512  275 VSPSKGSPEGGTILTIHGQFFDQTDLPVRVLVGGQACDILNVTENTIYCKTPP 327
Cdd:pfam01833    6 ISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPP 58
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1657-1743 1.28e-09

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 57.86  E-value: 1.28e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1657 PNIDLVMPKAGSTTGLTRVTIQGSGFMASSAGVEVFMGDFPCKVLNVTYTAIECETSPAPHQL-VLVDLLIHGVPAQCQG 1735
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGVPCSVLSVSSTAIVCTTPPYANPGpGPVEVTVDRGNGGITS 80


                   ....*....
gi 1958789512 1736 NC-SFSYLD 1743
Cdd:cd00102     81 SPlTFTYVP 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1156-1234 1.29e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.46  E-value: 1.29e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1156 QISHVWPDSGSLAGGTLLTISGFGFSKNS---TVLVGNETCNVIEGDLNRITCRTSKRIEGTVDISVITNGIQATSKD-S 1231
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSNFGTDSsdlKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPlT 81


                   ...
gi 1958789512 1232 FSY 1234
Cdd:pfam01833   82 FTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1240-1317 1.48e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.46  E-value: 1.48e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958789512 1240 PVVTDFSPKERTILGTVNLTIKGYNFGSELTQNTVYVGGKHCQILHSNFTDITCLLPTLPPGKHEIYVKVRNWGLAST 1317
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 2089-2159 1.68e-09

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 57.23  E-value: 1.68e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958789512 2089 PLIIEVSPRRGSTAGGTRLTVTGSgfSENT-EDVQVTIANSKCDVQYSNKTHIVCMTSAHAPSGWAPVLVNI 2159
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGK--HLNAgSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGEAPVKVLI 70
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 275-363 2.23e-09

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 56.85  E-value: 2.23e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  275 VSPSKGSPEGGTILTIHGQFFDqTDLPVRVLVGGQACDILNVTENTIYCKTPPKPHVLKAtypggrglKIEVWNNSRPTH 354
Cdd:cd01179      6 LSPSYGPQSGGTRLTITGKHLN-AGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGEA--------PVKVLIDGARRL 76


                   ....*....
gi 1958789512  355 LEDILEYSE 363
Cdd:cd01179     77 APLVFTYTE 85
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1329-1394 2.32e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 56.69  E-value: 2.32e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958789512 1329 LEVTHMFPQRGSLYGGTEITIIGSGFSTIPTENSVLLGSFPCDITSSSENVIKCTL-HSTGAVFRIT 1394
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTpPGTSGLVNVS 67
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 31-126 2.38e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 57.08  E-value: 2.38e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512   31 PKVTEVIPKYGSINGATRLTIKGEGFSQASqfnygadnielgnhVQLVSSFQSITCDVEkdSTHSTQITCYTRAMPEDV- 109
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGS--------------PRVRVTVGGVPCKVL--NVSSTEIVCRTPAAATPGe 64

                           90
                   ....*....|....*..
gi 1958789512  110 YSVRVSVDGVPVAENNT 126
Cdd:cd00603     65 GPVEVTVDGANVSARVL 81
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 2089-2161 3.42e-09

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 56.56  E-value: 3.42e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958789512 2089 PLIIEVSPRRGSTAGGTRLTVTGS--GFSENTEDVQVTIANSKCDVQ---YSNKTHIVCMT-SAHAPSGWAPVLVNIKN 2161
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSnlGLRKNDVRHGVRVGGVPCNPEppeYSSSEKIVCTTgPAGNPVFNGPVEVTVGH 79
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1998-2084 4.14e-09

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 56.32  E-value: 4.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1998 SIQSISPRKGSFGGGQTLTVTGMGFDP-WNSTILVGGS-ECAVDKllSNSTTLFCEIPPNNGKGPDQAcGVSVVNGKDSS 2075
Cdd:cd00102      2 VITSISPSSGPVSGGTEVTITGSNFGSgSNLRVTFGGGvPCSVLS--VSSTAIVCTTPPYANPGPGPV-EVTVDRGNGGI 78

                           90
                   ....*....|
gi 1958789512 2076 QSVTL-FTYM 2084
Cdd:cd00102     79 TSSPLtFTYV 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1747-1825 4.70e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.92  E-value: 4.70e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1747 PYVTGVFPNS--IQGSGSVLIIGEGFGTVLEEISIFIGIQKFRVLDVNENNITVLMTPLAAGLHSLSVVVGSKGLALGNL 1824
Cdd:pfam01833    1 PVITSISPSSgpASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   .
gi 1958789512 1825 S 1825
Cdd:pfam01833   81 T 81
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1067-1143 6.67e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.53  E-value: 6.67e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958789512 1067 PLILTTTPSEGSYAESTILTIAGSGFSPTS-AVSVSVGSTQCSLLSVEENEIKCQILNGSAGHVPVAVSIAGVGLAQN 1143
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1240-1317 7.58e-09

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 55.55  E-value: 7.58e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1240 PVVTDFSPKERTILGTVNLTIKGYNFGSELTQnTVYVGG-KHCQILHSNFTDITCLLPTLP-PGKHEIYVKVRNWGLAST 1317
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNL-RVTFGGgVPCSVLSVSSTAIVCTTPPYAnPGPGPVEVTVDRGNGGIT 79
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1330-1384 1.45e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 54.77  E-value: 1.45e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958789512 1330 EVTHMFPQRGSLYGGTEITIIGSGFSTIPTENSVLLGSFPCDITSSSENVIKCTL 1384
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRT 56
IPT smart00429
ig-like, plexins, transcription factors;
2089-2174 2.53e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 53.96  E-value: 2.53e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  2089 PLIIEVSPRRGSTAGGTRLTVTGSGF-SENTEDVQVTIANSKCDVQYSNKTHIVCMTSAHAPSgwaPVLVNIKNIGV--- 2164
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLkSISVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNI---PGSVPVRTVGLrng 78

                            90
                    ....*....|.
gi 1958789512  2165 -AKLENADFLY 2174
Cdd:smart00429   79 gVPSSPQPFTY 89
IPT smart00429
ig-like, plexins, transcription factors;
1829-1908 6.92e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 52.81  E-value: 6.92e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  1829 PAVASVSPTSGSIAGGTTLMITGNGFSPGNT---TVTVGDQPCQIMFINSSEVHCSTPAGRAGTANLKIDVNS-----VI 1900
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVvfvEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGlrnggVP 81


                    ....*...
gi 1958789512  1901 YPSLSFTY 1908
Cdd:smart00429   82 SSPQPFTY 89
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1914-1995 7.15e-08

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 52.85  E-value: 7.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1914 PFLKSIIPNSGPP--GTEVEITGSNLGFaVSDVLVMIKESV-CNVTTVNDTVLQCIVGE-HAGGIFPVMMLHKTKGSAI- 1988
Cdd:cd00102      1 PVITSISPSSGPVsgGTEVTITGSNFGS-GSNLRVTFGGGVpCSVLSVSSTAIVCTTPPyANPGPGPVEVTVDRGNGGIt 79


                   ....*...
gi 1958789512 1989 -SSVVFEY 1995
Cdd:cd00102     80 sSPLTFTY 87
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1067-1154 2.27e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 51.30  E-value: 2.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1067 PLILTTTPSEGSYAESTILTIAGSGFSPTSA-VSVSVGSTQCSLLSVEENEIKCQIL-NGSAGHVPVAVSIaGVGLAQNL 1144
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrVRVTVGGVPCKVLNVSSTEIVCRTPaAATPGEGPVEVTV-DGANVSAR 79

                           90
                   ....*....|
gi 1958789512 1145 EGEGSHFVYQ 1154
Cdd:cd00603     80 VLSNTTFTYV 89
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1157-1234 2.83e-07

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 51.16  E-value: 2.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1157 ISHVWPDSGSLAGGTLLTISG--FGFSKN---STVLVGNETCNVIEG---DLNRITCRT----SKRIEGTVDISVITNGI 1224
Cdd:cd01180      3 ITEFFPLSGPLEGGTRLTICGsnLGLRKNdvrHGVRVGGVPCNPEPPeysSSEKIVCTTgpagNPVFNGPVEVTVGHGSF 82

                           90
                   ....*....|
gi 1958789512 1225 QATSKDSFSY 1234
Cdd:cd01180     83 RTESSEGFSF 92
IPT smart00429
ig-like, plexins, transcription factors;
1998-2084 3.27e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 50.88  E-value: 3.27e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  1998 SIQSISPRKGSFGGGQTLTVTGMGFDPWNS---TILVGGSECAVdkLLSNSTTLFCEIPP-NNGKGPDQACGVSVVNGKD 2073
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSISVvfvEVGVGEAPCTF--SPSSSTAIVCKTPPyHNIPGSVPVRTVGLRNGGV 80

                            90
                    ....*....|.
gi 1958789512  2074 SSQSVTlFTYM 2084
Cdd:smart00429   81 PSSPQP-FTYV 90
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 31-128 3.55e-07

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 50.92  E-value: 3.55e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512   31 PKVTEVIPKYGSINGATRLTIKGEGFSQasqfnygadnielGNHVQlVSSFQSITCDVEkdSTHSTQITCYTRAMPEDV- 109
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGS-------------GSNLR-VTFGGGVPCSVL--SVSSTAIVCTTPPYANPGp 64

                           90
                   ....*....|....*....
gi 1958789512  110 YSVRVSVDGVPVAENNTCK 128
Cdd:cd00102     65 GPVEVTVDRGNGGITSSPL 83
PA14 pfam07691
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 371-467 4.60e-07

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


Pssm-ID: 400161 [Multi-domain]  Cd Length: 141  Bit Score: 51.98  E-value: 4.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  371 ASWTDSASYvwPIEQDTFVARISGFLVPPDSDVYRFYIRGDDRYAIYFSqtghpeDKVRIAYysrNANTYFSSSTQKSDE 450
Cdd:pfam07691   31 YWDTDVPGF--GEAPGDFSARWTGYLLPPESGTYTFGVASDDGARLWID------GELVIDN---WGQHPPDASPEESNT 99

                           90
                   ....*....|....*..
gi 1958789512  451 IHLQKGKEYYIEILLQE 467
Cdd:pfam07691  100 LYLVAGKLYPIRIEYFH 116
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1329-1383 1.81e-06

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 48.61  E-value: 1.81e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958789512 1329 LEVTHMFPQRGSLYGGTEITIIGSGFSTIPTENSVLLGSFPCDITSSSENVIKCT 1383
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGVPCSVLSVSSTAIVCT 55
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1657-1741 4.08e-06

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 47.60  E-value: 4.08e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1657 PNIDLVMPKAGSTTGLTRVTIQGSGFMASSAgVEVFMGDFPCKVLNVTYTAIECETSPA--PHQlVLVDLLIHGvpAQCQ 1734
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSS-VRVTVGGQPCKILSVSSSQIVCLTPPSasPGE-APVKVLIDG--ARRL 76


                   ....*..
gi 1958789512 1735 GNCSFSY 1741
Cdd:cd01179     77 APLVFTY 83
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1829-1908 4.26e-06

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 47.70  E-value: 4.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1829 PAVASVSPTSGSIAGGTTLMITGN--GFSPG--NTTVTVGDQPCQIM---FINSSEVHCST-PAGR-AGTANLKIDVNSV 1899
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSnlGLRKNdvRHGVRVGGVPCNPEppeYSSSEKIVCTTgPAGNpVFNGPVEVTVGHG 80

                           90
                   ....*....|..
gi 1958789512 1900 IYPSLS---FTY 1908
Cdd:cd01180     81 SFRTESsegFSF 92
PA14 smart00758
domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, ...
 372-467 5.63e-06

domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins;


Pssm-ID: 214807 [Multi-domain]  Cd Length: 136  Bit Score: 48.94  E-value: 5.63e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512   372 SWTDSASYvwPIEQDTFVARISGFLVPPDSDVYRFYIRGDDRYAIYFSqtghpeDKVRIayySRNANTYFSSSTqkSDEI 451
Cdd:smart00758   30 WDSDKFGE--GEKADNFSVRWTGYLKPPEDGEYTFSITSDDGARLWID------GKLVI---DNWGKHEARPST--SSTL 96

                            90
                    ....*....|....*.
gi 1958789512   452 HLQKGKEYYIEILLQE 467
Cdd:smart00758   97 YLLAGGTYPIRIEYFE 112
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1998-2084 6.36e-06

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 47.31  E-value: 6.36e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1998 SIQSISPRKGSFGGGQTLTVTG--MGFDPW--NSTILVGGSECAVDKLL-SNSTTLFCEIPPNNGKGPDQACGVSVVNGK 2072
Cdd:cd01180      2 VITEFFPLSGPLEGGTRLTICGsnLGLRKNdvRHGVRVGGVPCNPEPPEySSSEKIVCTTGPAGNPVFNGPVEVTVGHGS 81

                           90
                   ....*....|..
gi 1958789512 2073 DSSQSVTLFTYM 2084
Cdd:cd01180     82 FRTESSEGFSFV 93
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1067-1155 7.11e-06

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 47.07  E-value: 7.11e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1067 PLILTTTPSEGSYAESTILTIAGSGFSPTSAVSVSV-GSTQCSLLSVEENEIKCQI---LNGSAGHVPVAVSIAGVGLAQ 1142
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFgGGVPCSVLSVSSTAIVCTTppyANPGPGPVEVTVDRGNGGITS 80

                           90
                   ....*....|...
gi 1958789512 1143 NlegeGSHFVYQS 1155
Cdd:cd00102     81 S----PLTFTYVP 89
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 3254-3510 1.29e-05

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 50.69  E-value: 1.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 3254 ILSRNIKIVGEDYSVwskdsfgariLVGSFTGNMMTFKG-NARISNVEFYHSGqegyRDSTDPRYAVTFLNlgqiqDHGL 3332
Cdd:COG3420     49 VIDKPLTLIGEGGAV----------IDGGGKGTVITITAdNVTVRGLTITGSG----DSLTDDDAGIYVRG-----ADNA 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 3333 SyVRGCAFHHGFSpAIGVFGTNGVDIDDNIIY------FTVGEGIRIWG-DANRVRGNLVTlsvwpgtyQNRkDlsstlw 3405
Cdd:COG3420    110 V-IENNRIENNLF-GIYLEGSDNNVIRNNTISgnrdlrADRGNGIHLWNsPGNVIEGNTIS--------GGR-D------ 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 3406 haAIEINRGTNTVLQNNIVAGfGRVGYRIDgepcSSQANpmeNWFNNEAHGGLYGIY-MNQDGLpgcsLIQGFTIWACWD 3484
Cdd:COG3420    173 --GIYLEFSDNNVIRNNTIRN-LRYGIHYM----YSNDN---LVEGNTFRDNGAGIAlMYSKGN----TVRGNTILGNSG 238

                          250       260
                   ....*....|....*....|....*.
gi 1958789512 3485 YGIYFQTMESVHIYNVTLVNNGMAIF 3510
Cdd:COG3420    239 YGILLKESSDSVIEGNTISGNGKGIF 264
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 31-126 1.63e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 45.90  E-value: 1.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512   31 PKVTEVIPKYGSINGATRLTIKGEGFSQASqfnygaDNIELgnhvqlvsSFQSITCDVEKDSthSTQITCYTRAMPEDVY 110
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDS------SDLKV--------TIGGTPCTVISVS--STTIVCTTPPGTSGLV 64

                           90
                   ....*....|....*.
gi 1958789512  111 SVRVSVDGVPVAENNT 126
Cdd:pfam01833   65 NVSVTVGGGGISSSPL 80
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1914-1995 3.65e-05

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 45.38  E-value: 3.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1914 PFLKSIIPNSGPP--GTEVEITGSNLGFAVSDVL--VMIKESVCNVTT---VNDTVLQCIVGEHAGGIFP----VMMLHK 1982
Cdd:cd01180      1 PVITEFFPLSGPLegGTRLTICGSNLGLRKNDVRhgVRVGGVPCNPEPpeySSSEKIVCTTGPAGNPVFNgpveVTVGHG 80

                           90
                   ....*....|...
gi 1958789512 1983 TKGsAISSVVFEY 1995
Cdd:cd01180     81 SFR-TESSEGFSF 92
IPT smart00429
ig-like, plexins, transcription factors;
1329-1384 6.31e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 44.33  E-value: 6.31e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958789512  1329 LEVTHMFPQRGSLYGGTEITIIGSGFSTIPTEN-SVLLGSFPCDITSSSENVIKCTL 1384
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFvEVGVGEAPCTFSPSSSTAIVCKT 58
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1564-1622 6.54e-05

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 44.37  E-value: 6.54e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958789512 1564 PSIINITPSTGTANE--LITITGHGFSNLTCANKVTIGSYPCVVEESNENSIMCHIDPQNS 1622
Cdd:cd00603      1 PVITSISPSSGPLSGgtRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAT 61
IPT smart00429
ig-like, plexins, transcription factors;
1157-1234 7.67e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 44.33  E-value: 7.67e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  1157 ISHVWPDSGSLAGGTLLTISGFGF----SKNSTVLVGNETCNVIEGDLNRITCRTSKRIEGTVDISVITNGIQ----ATS 1228
Cdd:smart00429    4 ITRISPTSGPVSGGTEITLCGKNLksisVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRnggvPSS 83


                    ....*.
gi 1958789512  1229 KDSFSY 1234
Cdd:smart00429   84 PQPFTY 89
IPT smart00429
ig-like, plexins, transcription factors;
1067-1153 8.80e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 43.95  E-value: 8.80e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  1067 PLILTTTPSEGSYAESTILTIAGSGFSPTSAVSVSV--GSTQCSLLSVEENEIKCQILNGSAGHVPVAVSIAGVGLAqNL 1144
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVgvGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRNG-GV 80


                    ....*....
gi 1958789512  1145 EGEGSHFVY 1153
Cdd:smart00429   81 PSSPQPFTY 89
IPT smart00429
ig-like, plexins, transcription factors;
1656-1742 1.01e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 43.95  E-value: 1.01e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  1656 LPNIDLVMPKAGSTTGLTRVTIQGSGFMASSAGVEVFMGDF-PCKVLNVTYTAIECETSPAPHQLVL-----VDLLIHGV 1729
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEaPCTFSPSSSTAIVCKTPPYHNIPGSvpvrtVGLRNGGV 80

                            90
                    ....*....|...
gi 1958789512  1730 PAQCQgncSFSYL 1742
Cdd:smart00429   81 PSSPQ---PFTYV 90
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1157-1234 2.16e-04

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 42.60  E-value: 2.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1157 ISHVWPDSGSLAGGTLLTISGFGFSKNST--VLVGNETCNVIEGDLNRITCRTSKRIE-GTVDISVITNGIQATSKDSFS 1233
Cdd:cd01179      3 ITSLSPSYGPQSGGTRLTITGKHLNAGSSvrVTVGGQPCKILSVSSSQIVCLTPPSASpGEAPVKVLIDGARRLAPLVFT 82


                   .
gi 1958789512 1234 Y 1234
Cdd:cd01179     83 Y 83
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1240-1309 2.26e-04

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 43.07  E-value: 2.26e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958789512 1240 PVVTDFSPKERTILGTVNLTIKGYNFGS--ELTQNTVYVGGKHCQILHSNFTD---ITCLLPTLPPGKHEIYVKV 1309
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLrkNDVRHGVRVGGVPCNPEPPEYSSsekIVCTTGPAGNPVFNGPVEV 75
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 146-255 4.44e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 41.66  E-value: 4.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  146 PTIRSITPLSGTP--GTLITIQGRLFtdvygsntalssnGRNVRILRTYIGGMPCELLiphsddlyglkldhpSRDTGSV 223
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNF-------------GTDSSDLKVTIGGTPCTVI---------------SVSSTTI 52

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1958789512  224 TCKATGTYIGHHNVSFILDSDYGRSFPENTTY 255
Cdd:pfam01833   53 VCTTPPGTSGLVNVSVTVGGGGISSSPLTFTY 84
Halocyanin cd04220
Halocyanin is an archaea blue (type I) copper redox protein; Halocyanins are blue (type I) ...
 1405-1478 4.65e-04

Halocyanin is an archaea blue (type I) copper redox protein; Halocyanins are blue (type I) copper redox proteins found in halophilic archaea such as Natronomonas pharaonis (Natronobacterium pharaonis). Halocyanin may serve as a mobile electron carrier at a peripheral membrane protein. The copper-binding domain is present only once in some halocyanins and is duplicated in others.


Pssm-ID: 259882 [Multi-domain]  Cd Length: 92  Bit Score: 41.99  E-value: 4.65e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958789512 1405 GYAWSPSVLNVTVGDTVVWYWRAHpflrGIGYRIfsVSSPGSVTYDGKGFTNgrqKSASGSFSYQFTSPGVHYY 1478
Cdd:cd04220     11 GFAFDPAAIRVSPGTTVTWEWTGE----GGGHNV--VAYEDPITAFDSGSTD---SSEGETYEHTFEETGEYRY 75
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1914-1995 4.73e-04

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 41.83  E-value: 4.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1914 PFLKSIIPNSGPP--GTEVEITGSNLGfAVSDVLVMIKESVCNVTTVNDTVLQCIVGEHA-GGIFPVMMLHktkGSAI-- 1988
Cdd:cd01179      1 PSITSLSPSYGPQsgGTRLTITGKHLN-AGSSVRVTVGGQPCKILSVSSSQIVCLTPPSAsPGEAPVKVLI---DGARrl 76


                   ....*..
gi 1958789512 1989 SSVVFEY 1995
Cdd:cd01179     77 APLVFTY 83
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1067-1153 5.69e-04

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 41.44  E-value: 5.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1067 PLILTTTPSEGSYAESTILTIAGSGFSPTSAVSVSVGSTQCSLLSVEENEIKCQILNGSAGH-VPVAVSIagvGLAQNLe 1145
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGeAPVKVLI---DGARRL- 76


                   ....*...
gi 1958789512 1146 gEGSHFVY 1153
Cdd:cd01179     77 -APLVFTY 83
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1657-1716 6.36e-04

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 41.53  E-value: 6.36e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958789512 1657 PNIDLVMPKAGSTTGLTRVTIQGSGFMASSAGVE--VFMGDFPCKVLNVTY---TAIECETSPAP 1716
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRhgVRVGGVPCNPEPPEYsssEKIVCTTGPAG 65
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 146-256 7.74e-04

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 41.29  E-value: 7.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  146 PTIRSITPLSGTP--GTLITIqgrlftdvYGSNtaLSSNGRNVRIlrtYIGGMPCELLiphsddlyglkldhpSRDTGSV 223
Cdd:cd00603      1 PVITSISPSSGPLsgGTRLTI--------TGSN--LGSGSPRVRV---TVGGVPCKVL---------------NVSSTEI 52

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1958789512  224 TCKA-TGTYIGHHNVSFILDSDYGRSFPENTTYF 256
Cdd:cd00603     53 VCRTpAAATPGEGPVEVTVDGANVSARVLSNTTF 86
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 275-329 8.12e-04

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 41.53  E-value: 8.12e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  275 VSPSKGSPEGGTILTIHGQFF--DQTDLPVRVLVGGQACDILN---VTENTIYCKTPPKP 329
Cdd:cd01180      6 FFPLSGPLEGGTRLTICGSNLglRKNDVRHGVRVGGVPCNPEPpeySSSEKIVCTTGPAG 65
PetE COG3794
Plastocyanin [Energy production and conversion];
1406-1498 8.66e-04

Plastocyanin [Energy production and conversion];


Pssm-ID: 443008 [Multi-domain]  Cd Length: 76  Bit Score: 40.75  E-value: 8.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1406 YAWSPSVLNVTVGDTVVWYWRAhpflrGIGYRIFSVSSPgsvtydGKGFTNGRQKsASGSFSYQFTSPGVHYyssgYVDE 1485
Cdd:COG3794      1 MAFEPATLTVKPGDTVTWVNTD-----SVPHNVTSDDGP------DGAFDSGLLA-PGETFSVTFDEPGTYD----YYCT 64

                           90
                   ....*....|...
gi 1958789512 1486 THSiSLQGVINVV 1498
Cdd:COG3794     65 PHP-WMVGTIVVG 76
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 3326-3505 9.37e-04

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 42.78  E-value: 9.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 3326 QIQDHGLSYVRGCAFHHGFSPAIGVFGTNGVDIDDNIIYFTVGEGIRIWGDAN-RVRGNLVTLSvwpgtyqnrkdlsstl 3404
Cdd:pfam13229    4 LLNGSSNATIKNNTISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNnTISNNTISNN---------------- 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 3405 WHAAIEINRGTNTVLQNNIVAGFGRVGYRIDGepcSSQANPMENWFNNeahGGLYGIYMNQDGLPGcsLIQGFTIWACWD 3484
Cdd:pfam13229   68 GGGGIALRGSSNNLIENNTISNNGGAGIYLSD---SSNNTIENNIIHN---NGGSGIVIEDSSNNV--TISNNTVTNNKG 139

                          170       180
                   ....*....|....*....|.
gi 1958789512 3485 YGIYFQTmesvHIYNVTLVNN 3505
Cdd:pfam13229  140 AGILIVG----GSSNNTVENN 156
IPT_NFAT cd01178
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ...
 1999-2083 1.08e-03

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.


Pssm-ID: 238583  Cd Length: 101  Bit Score: 41.32  E-value: 1.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1999 IQSISPRKGSFGGGQTLTVTGMGFDPWNSTILVGGS---------ECAVDKLLSNSTTLFCEIPPNNGK---GPDQAcGV 2066
Cdd:cd01178      4 IEKKSLNSCSVNGGEELFLTGKNFLKDSKVVFQEKGqdgeaqweaEATIDKEKSHQNHLVVEVPPYHNKhvaAPVQV-QF 82

                           90
                   ....*....|....*..
gi 1958789512 2067 SVVNGKDSSQSVTLFTY 2083
Cdd:cd01178     83 YVVNGKRKRSQPQTFTY 99
Amicyanin cd13921
Amicyanin is a type I blue copper protein that plays an essential role in electron transfer; ...
 1398-1478 1.16e-03

Amicyanin is a type I blue copper protein that plays an essential role in electron transfer; In Paracoccus denitrificans bacteria, amicyanin acts as an intermediary of a three-member redox complex along with methylamine dehydrogenase (MADH) and cytochrome c-551i. The electron is transferred from the active site of MADH via the amicyanin copper ion to the cytochrome heme iron. The electron transfer from MADH to cytochrome c-551i does not involve a ternary complex but occurs via a ping-pong mechanism in which amicyanin uses the same interface for the reactions with MADH and cytochrome c-551i.


Pssm-ID: 259988 [Multi-domain]  Cd Length: 81  Bit Score: 40.39  E-value: 1.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512 1398 SHLVHGLGYAWSPSVLNVTVGDTVVWywrahpflrgigyrIFSVSSPGSVTYDGKGFTnGRQKSASGSFSYQFTSPGVHY 1477
Cdd:cd13921      1 THVVTIEDFKFNPAEVTVKVGDTVTW--------------TNKDSVPHTVTAEDGAFD-SGMLATGKSFSYTFTAAGTYD 65


                   .
gi 1958789512 1478 Y 1478
Cdd:cd13921     66 Y 66
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1331-1383 1.20e-03

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 40.67  E-value: 1.20e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958789512 1331 VTHMFPQRGSLYGGTEITIIG----SGFSTiptenSVLLGSFPCDITSSSENVIKCT 1383
Cdd:cd01179      3 ITSLSPSYGPQSGGTRLTITGkhlnAGSSV-----RVTVGGQPCKILSVSSSQIVCL 54
IPT smart00429
ig-like, plexins, transcription factors;
31-119 1.70e-03

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.48  E-value: 1.70e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512    31 PKVTEVIPKYGSINGATRLTIKGEGFSQASQFNYGADNIElgnhvqlvssfqsITCDVekDSTHSTQITCYTRAMPEDVY 110
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGE-------------APCTF--SPSSSTAIVCKTPPYHNIPG 66


                    ....*....
gi 1958789512   111 SVRVSVDGV 119
Cdd:smart00429   67 SVPVRTVGL 75
IPT smart00429
ig-like, plexins, transcription factors;
1918-1977 2.15e-03

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.10  E-value: 2.15e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958789512  1918 SIIPNSGPP--GTEVEITGSNLG-FAVSDVLVMIKESVCNVTTVNDTVLQCIVGEHAGGIFPV 1977
Cdd:smart00429    6 RISPTSGPVsgGTEITLCGKNLKsISVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSV 68
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 31-118 2.18e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 39.99  E-value: 2.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512   31 PKVTEVIPKYGSINGATRLTIKGEGFSQasqfnygadNIELGNHVQLVSsfqSITCDVEKDSTH-STQITCYTRAMPEDV 109
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGL---------RKNDVRHGVRVG---GVPCNPEPPEYSsSEKIVCTTGPAGNPV 68

                           90
                   ....*....|.
gi 1958789512  110 YS--VRVSVDG 118
Cdd:cd01180     69 FNgpVEVTVGH 79
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 146-203 9.78e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 38.45  E-value: 9.78e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789512  146 PTIRSITPLSGTP--GTLITIqgrlftdvYGSNTALSSNGRNVRIlrtYIGGMPCELLIP 203
Cdd:cd01180      1 PVITEFFPLSGPLegGTRLTI--------CGSNLGLRKNDVRHGV---RVGGVPCNPEPP 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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