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Conserved domains on  [gi|1952522263|ref|XP_038654450|]
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kelch-like protein 40b [Scyliorhinus canicula]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 6-139 1.18e-81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18340:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 134  Bit Score: 252.83  E-value: 1.18e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263   6 DPAEEPRIYQQTLLQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVE 85
Cdd:cd18340     1 DQVEELRLYQQTLLQDGLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1952522263  86 VLLRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLAIF 139
Cdd:cd18340    81 KILHYIYTSEIEITEQNVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAIF 134
PHA03098 super family cl33709
kelch-like protein; Provisional
 47-545 6.90e-60

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 208.85  E-value: 6.90e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  47 HRLVLAACSPYFRAMFLSDleeSKKREITLEDVEpEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYL 126
Cdd:PHA03098   26 HKIILSSSSEYFKKMFKNN---FKENEINLNIDY-DSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINYI 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 127 QKRLGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAH 206
Cdd:PHA03098  102 IKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 207 EESH-LKALPELFDCIRFLLMPKEYLKEHVEGNPTVKSSPELLKKIQL----VKDAQEGKGPFAKTKKEKAVAVKTKSGE 281
Cdd:PHA03098  182 KKNNkYKDICLILKVLRITFLSEEGIKKLKRWKLRIKKKKIVFNKRCIkiiySKKYNLNKILPRSSTFGSIIYIHITMSI 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 282 DAVGGEAKEAEEELVPGILNENLRFGM---FVKDLIFMIN--------DEATVAYDPTNNECY-FASISSkiPKNHTSIV 349
Cdd:PHA03098  262 FTYNYITNYSPLSEINTIIDIHYVYCFgsvVLNNVIYFIGgmnknnlsVNSVVSYDTKTKSWNkVPELIY--PRKNPGVT 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 350 TKQNQIFVAGGLYYNEgdkenpLHSYFLQFDHLDCDWLGMPPLPSPRCLFGLGEAENAIYVIGGkeVNEGEKTLDTVMCY 429
Cdd:PHA03098  340 VFNNRIYVIGGIYNSI------SLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG--ISKNDELLKTVECF 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 430 DRHTFKWGESDPLPYEVYGHSVVSHNEKVYVIGGKGIAK--KCLNKMCVYNPQRFEWKELAPMKTARSLFGAIVHRDKIW 507
Cdd:PHA03098  412 SLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDniKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIY 491

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1952522263 508 VATGVTDSGLTGSIEVYDITTNKWEEMVEFPQERSSLS 545
Cdd:PHA03098  492 VVGGDKYEYYINEIEVYDDKTNTWTLFCKFPKVIGSLE 529
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 541-587 2.03e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


:

Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.44  E-value: 2.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1952522263 541 RSSLSLVTLSKCLYAIGGFAMmqteagdfvPTEINDIWKYDDEKEEW 587
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDG---------NQSLNSVEVYDPETNTW 39
 
Name Accession Description Interval E-value
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-139 1.18e-81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 252.83  E-value: 1.18e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263   6 DPAEEPRIYQQTLLQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVE 85
Cdd:cd18340     1 DQVEELRLYQQTLLQDGLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1952522263  86 VLLRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLAIF 139
Cdd:cd18340    81 KILHYIYTSEIEITEQNVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAIF 134
PHA03098 PHA03098
kelch-like protein; Provisional
 47-545 6.90e-60

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 208.85  E-value: 6.90e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  47 HRLVLAACSPYFRAMFLSDleeSKKREITLEDVEpEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYL 126
Cdd:PHA03098   26 HKIILSSSSEYFKKMFKNN---FKENEINLNIDY-DSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINYI 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 127 QKRLGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAH 206
Cdd:PHA03098  102 IKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 207 EESH-LKALPELFDCIRFLLMPKEYLKEHVEGNPTVKSSPELLKKIQL----VKDAQEGKGPFAKTKKEKAVAVKTKSGE 281
Cdd:PHA03098  182 KKNNkYKDICLILKVLRITFLSEEGIKKLKRWKLRIKKKKIVFNKRCIkiiySKKYNLNKILPRSSTFGSIIYIHITMSI 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 282 DAVGGEAKEAEEELVPGILNENLRFGM---FVKDLIFMIN--------DEATVAYDPTNNECY-FASISSkiPKNHTSIV 349
Cdd:PHA03098  262 FTYNYITNYSPLSEINTIIDIHYVYCFgsvVLNNVIYFIGgmnknnlsVNSVVSYDTKTKSWNkVPELIY--PRKNPGVT 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 350 TKQNQIFVAGGLYYNEgdkenpLHSYFLQFDHLDCDWLGMPPLPSPRCLFGLGEAENAIYVIGGkeVNEGEKTLDTVMCY 429
Cdd:PHA03098  340 VFNNRIYVIGGIYNSI------SLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG--ISKNDELLKTVECF 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 430 DRHTFKWGESDPLPYEVYGHSVVSHNEKVYVIGGKGIAK--KCLNKMCVYNPQRFEWKELAPMKTARSLFGAIVHRDKIW 507
Cdd:PHA03098  412 SLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDniKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIY 491

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1952522263 508 VATGVTDSGLTGSIEVYDITTNKWEEMVEFPQERSSLS 545
Cdd:PHA03098  492 VVGGDKYEYYINEIEVYDDKTNTWTLFCKFPKVIGSLE 529
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 130-227 3.53e-53

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 176.87  E-value: 3.53e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 130 LGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-E 208
Cdd:cd18516     1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDqE 80

                          90
                  ....*....|....*....
gi 1952522263 209 SHLKALPELFDCIRFLLMP 227
Cdd:cd18516    81 ERTKALPVLLESIRFRLMP 99
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 23-130 2.23e-35

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 128.91  E-value: 2.23e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  23 LRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVqLNDNN 102
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 1952522263 103 VQDIFTAANMFQIPSIFTVCISYLQKRL 130
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 135-234 8.23e-33

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 121.29  E-value: 8.23e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  135 CLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-ESHLKA 213
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDpEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 1952522263  214 LPELFDCIRFLLMPKEYLKEH 234
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 135-236 1.32e-30

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 115.34  E-value: 1.32e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 135 CLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAH-EESHLKA 213
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHdVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 1952522263 214 LPELFDCIRFLLMPKEYLKEHVE 236
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
385-559 2.28e-30

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 120.26  E-value: 2.28e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 385 DWLGMPPLPSPRCLFGLGEAENAIYVIGGkevNEGEKTLDTVMCYDRHTFKWGESDPLPYEVYGHSV-VSHNEKVYVIGG 463
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGG---LSGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAaVAQDGKLYVFGG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 464 KGIAK---KCLNKMCVYNPQRFEWKELAPMKTARSLFGAIVHRDKIWVATGVTDSGLTGSIEVYDITTNKWEEMVEFPQE 540
Cdd:COG3055    79 FTGANpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTP 158

                         170       180
                  ....*....|....*....|.
gi 1952522263 541 RSSLSLVTLS--KcLYAIGGF 559
Cdd:COG3055   159 RDHLAAAVLPdgK-ILVIGGR 178
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 34-130 3.16e-30

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 113.94  E-value: 3.16e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263   34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMF 113
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 1952522263  114 QIPSIFTVCISYLQKRL 130
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
mutarot_permut TIGR03548
cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...
 434-587 5.49e-06

cyclically-permuted mutarotase family protein; Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.


Pssm-ID: 274642 [Multi-domain]  Cd Length: 331  Bit Score: 48.63  E-value: 5.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 434 FKWGESDPLPYEV-YGHSvVSHNEKVYVIGGKG----------IAKKCLNKMCVYNPqrfewkeLAPMKTARSLFGAIVH 502
Cdd:TIGR03548  52 LKWVKAGQLPYEIaYGAS-VSTPYGIYYVGGSPssesfsdvllLSLDDTKEALIIET-------LPSLPVAFDNGSATYK 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 503 RDKIWVATGVTDSGLTGSIEVYDI--TTNKWEEMVEFPQE-RSSLSLVTLSKCLYAIGGFammqTEAGDfvPTEINDIWK 579
Cdd:TIGR03548 124 DGKIYVGGGNANGKPSNKFYCLDLsnDTSGWEELPEFPGEaRVQPVCQALHGKLYVFGGF----QLGGD--AIIYTDGYA 197


                  ....*...
gi 1952522263 580 YDDEKEEW 587
Cdd:TIGR03548 198 YSPKTNTW 205
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 541-587 2.03e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.44  E-value: 2.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1952522263 541 RSSLSLVTLSKCLYAIGGFAMmqteagdfvPTEINDIWKYDDEKEEW 587
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDG---------NQSLNSVEVYDPETNTW 39
 
Name Accession Description Interval E-value
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-139 1.18e-81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 252.83  E-value: 1.18e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263   6 DPAEEPRIYQQTLLQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVE 85
Cdd:cd18340     1 DQVEELRLYQQTLLQDGLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1952522263  86 VLLRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLAIF 139
Cdd:cd18340    81 KILHYIYTSEIEITEQNVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAIF 134
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-138 5.74e-80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 248.47  E-value: 5.74e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263   6 DPAEEPRIYQQTLLQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVE 85
Cdd:cd18269     1 EQKEELRLYQQTLLQDGLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1952522263  86 VLLRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLAI 138
Cdd:cd18269    81 MILKYLYTSEIDLNDQNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-138 2.67e-63

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 205.08  E-value: 2.67e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263   8 AEEPRIYQQTLLQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVL 87
Cdd:cd18341     3 KEELRLYQSTLLQDGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMI 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1952522263  88 LRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLAI 138
Cdd:cd18341    83 LKYLYSAEIDLNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
PHA03098 PHA03098
kelch-like protein; Provisional
 47-545 6.90e-60

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 208.85  E-value: 6.90e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  47 HRLVLAACSPYFRAMFLSDleeSKKREITLEDVEpEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYL 126
Cdd:PHA03098   26 HKIILSSSSEYFKKMFKNN---FKENEINLNIDY-DSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINYI 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 127 QKRLGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAH 206
Cdd:PHA03098  102 IKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 207 EESH-LKALPELFDCIRFLLMPKEYLKEHVEGNPTVKSSPELLKKIQL----VKDAQEGKGPFAKTKKEKAVAVKTKSGE 281
Cdd:PHA03098  182 KKNNkYKDICLILKVLRITFLSEEGIKKLKRWKLRIKKKKIVFNKRCIkiiySKKYNLNKILPRSSTFGSIIYIHITMSI 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 282 DAVGGEAKEAEEELVPGILNENLRFGM---FVKDLIFMIN--------DEATVAYDPTNNECY-FASISSkiPKNHTSIV 349
Cdd:PHA03098  262 FTYNYITNYSPLSEINTIIDIHYVYCFgsvVLNNVIYFIGgmnknnlsVNSVVSYDTKTKSWNkVPELIY--PRKNPGVT 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 350 TKQNQIFVAGGLYYNEgdkenpLHSYFLQFDHLDCDWLGMPPLPSPRCLFGLGEAENAIYVIGGkeVNEGEKTLDTVMCY 429
Cdd:PHA03098  340 VFNNRIYVIGGIYNSI------SLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG--ISKNDELLKTVECF 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 430 DRHTFKWGESDPLPYEVYGHSVVSHNEKVYVIGGKGIAK--KCLNKMCVYNPQRFEWKELAPMKTARSLFGAIVHRDKIW 507
Cdd:PHA03098  412 SLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDniKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIY 491

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1952522263 508 VATGVTDSGLTGSIEVYDITTNKWEEMVEFPQERSSLS 545
Cdd:PHA03098  492 VVGGDKYEYYINEIEVYDDKTNTWTLFCKFPKVIGSLE 529
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 130-227 3.53e-53

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 176.87  E-value: 3.53e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 130 LGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-E 208
Cdd:cd18516     1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDqE 80

                          90
                  ....*....|....*....
gi 1952522263 209 SHLKALPELFDCIRFLLMP 227
Cdd:cd18516    81 ERTKALPVLLESIRFRLMP 99
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 130-227 8.67e-47

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 159.55  E-value: 8.67e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 130 LGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-E 208
Cdd:cd18517     1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDkE 80

                          90
                  ....*....|....*....
gi 1952522263 209 SHLKALPELFDCIRFLLMP 227
Cdd:cd18517    81 NRVKSLGEIFDCIRFRLMP 99
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 130-227 1.64e-46

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 158.85  E-value: 1.64e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 130 LGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWA-AHEE 208
Cdd:cd18477     1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVrEAKE 80

                          90
                  ....*....|....*....
gi 1952522263 209 SHLKALPELFDCIRFLLMP 227
Cdd:cd18477    81 NRQKALPTVFESIRFRLLP 99
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-137 3.53e-38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 137.04  E-value: 3.53e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  23 LRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNN 102
Cdd:cd18238     6 LHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLTVDN 85

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1952522263 103 VQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLA 137
Cdd:cd18238    86 VQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-113 1.08e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 128.83  E-value: 1.08e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  32 FVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAAN 111
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80


                  ..
gi 1952522263 112 MF 113
Cdd:cd18186    81 KL 82
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 23-130 2.23e-35

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 128.91  E-value: 2.23e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  23 LRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVqLNDNN 102
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 1952522263 103 VQDIFTAANMFQIPSIFTVCISYLQKRL 130
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-136 9.75e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 127.60  E-value: 9.75e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  22 GLRDlleNNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDN 101
Cdd:cd18237    14 NMRK---QKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISVNSN 90

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1952522263 102 NVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCL 136
Cdd:cd18237    91 NVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-136 1.63e-34

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 127.64  E-value: 1.63e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  16 QTLLqEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSE 95
Cdd:cd18259    17 QSIL-DGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYTGK 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1952522263  96 VQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCL 136
Cdd:cd18259    96 LTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCL 136
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-135 7.60e-34

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 124.95  E-value: 7.60e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  21 EGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLND 100
Cdd:cd18253     7 QVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKITT 86

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1952522263 101 NNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNC 135
Cdd:cd18253    87 ENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-135 1.58e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 124.11  E-value: 1.58e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  19 LQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQL 98
Cdd:cd18250     8 LLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTGRVTV 87

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1952522263  99 NDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNC 135
Cdd:cd18250    88 TQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-140 5.71e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 123.40  E-value: 5.71e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  19 LQEGLRDLLENNKFVDCILKVKGKE--------FPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRY 90
Cdd:cd18273    13 LLAQLKSFYDARLLTDVTIEVNGPGsgpgsgrlFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMALIIDY 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1952522263  91 IYSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLAIFR 140
Cdd:cd18273    93 CYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGILK 142
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 135-234 8.23e-33

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 121.29  E-value: 8.23e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  135 CLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-ESHLKA 213
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDpEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 1952522263  214 LPELFDCIRFLLMPKEYLKEH 234
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-138 1.02e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 122.40  E-value: 1.02e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263   5 IDPAEEPRIYQQtllqegLRDLLENNKFVDCILKVK-GKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEM 83
Cdd:cd18274     1 MDPLHACSILQQ------LKAMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAES 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1952522263  84 VEVLLRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLAI 138
Cdd:cd18274    75 MHLVLDYAYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-129 1.79e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 120.85  E-value: 1.79e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  31 KFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAA 110
Cdd:cd18247    18 KLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGRIAIDTSNVQSLLVGA 97

                          90
                  ....*....|....*....
gi 1952522263 111 NMFQIPSIFTVCISYLQKR 129
Cdd:cd18247    98 SFLQLQSVKDACCEFLKER 116
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-135 9.08e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 119.35  E-value: 9.08e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  23 LRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNN 102
Cdd:cd18240     8 FNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPITAEN 87

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1952522263 103 VQDIFTAANMFQIPSIFTVCISYLQKRLGLSNC 135
Cdd:cd18240    88 VEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-130 1.64e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 118.68  E-value: 1.64e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  29 NNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFT 108
Cdd:cd18235    18 QNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTAEIQVTEENVQVLLP 97

                          90       100
                  ....*....|....*....|..
gi 1952522263 109 AANMFQIPSIFTVCISYLQKRL 130
Cdd:cd18235    98 AANLLQLTDVRDACCDFLQSQL 119
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-138 2.78e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 117.98  E-value: 2.78e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  19 LQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQL 98
Cdd:cd18276     8 LLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSDLHL 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1952522263  99 NDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLAI 138
Cdd:cd18276    88 TNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-135 3.00e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 118.03  E-value: 3.00e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  17 TLLQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEV 96
Cdd:cd18236     9 LVLQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKV 88

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1952522263  97 QLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNC 135
Cdd:cd18236    89 LITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENC 127
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 135-236 1.32e-30

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 115.34  E-value: 1.32e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 135 CLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAH-EESHLKA 213
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHdVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 1952522263 214 LPELFDCIRFLLMPKEYLKEHVE 236
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
385-559 2.28e-30

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 120.26  E-value: 2.28e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 385 DWLGMPPLPSPRCLFGLGEAENAIYVIGGkevNEGEKTLDTVMCYDRHTFKWGESDPLPYEVYGHSV-VSHNEKVYVIGG 463
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGG---LSGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAaVAQDGKLYVFGG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 464 KGIAK---KCLNKMCVYNPQRFEWKELAPMKTARSLFGAIVHRDKIWVATGVTDSGLTGSIEVYDITTNKWEEMVEFPQE 540
Cdd:COG3055    79 FTGANpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTP 158

                         170       180
                  ....*....|....*....|.
gi 1952522263 541 RSSLSLVTLS--KcLYAIGGF 559
Cdd:COG3055   159 RDHLAAAVLPdgK-ILVIGGR 178
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 34-130 3.16e-30

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 113.94  E-value: 3.16e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263   34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMF 113
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 1952522263  114 QIPSIFTVCISYLQKRL 130
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-136 5.42e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 113.62  E-value: 5.42e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMF 113
Cdd:cd18234     3 DVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACLL 82

                          90       100
                  ....*....|....*....|...
gi 1952522263 114 QIPSIFTVCISYLQKRLGLSNCL 136
Cdd:cd18234    83 QLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-136 9.73e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 113.65  E-value: 9.73e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  14 YQQTLLQeGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYS 93
Cdd:cd18256     3 HASLILA-QLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYT 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1952522263  94 SEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCL 136
Cdd:cd18256    82 GVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCI 124
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-138 1.04e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 113.73  E-value: 1.04e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  18 LLQEgLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQ 97
Cdd:cd18268    10 LLRQ-LNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEIL 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1952522263  98 LNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLAI 138
Cdd:cd18268    89 ITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-135 1.31e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 113.31  E-value: 1.31e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  26 LLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQD 105
Cdd:cd18242    15 LRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTETVHVTVENVQE 94

                          90       100       110
                  ....*....|....*....|....*....|
gi 1952522263 106 IFTAANMFQIPSIFTVCISYLQKRLGLSNC 135
Cdd:cd18242    95 LLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-137 2.52e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 112.56  E-value: 2.52e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  32 FVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAAN 111
Cdd:cd18265    23 FTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLEASD 102

                          90       100
                  ....*....|....*....|....*.
gi 1952522263 112 MFQIPSIFTVCISYLQKRLGLSNCLA 137
Cdd:cd18265   103 LLQVSKLREACVRFLEGQLHPCNCLG 128
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
345-558 1.29e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 115.25  E-value: 1.29e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 345 HTSIVTKQNQIFVAGGLyynegDKENPLHSyFLQFDHLDCDWLGMPPLP-SPRCLFGLGEAENAIYVIGG-KEVNEGEKT 422
Cdd:COG3055    15 EAAAALLDGKVYVAGGL-----SGGSASNS-FEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGGfTGANPSSTP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 423 LDTVMCYDRHTFKWGESDPLPYEVYGHSVVSHNEKVYVIGGKGIAKKcLNKMCVYNPQRFEWKELAPMKTARSLFGAIVH 502
Cdd:COG3055    89 LNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGN-VAWVEVYDPATGTWTQLAPLPTPRDHLAAAVL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 503 RD-KIWVATGVTDSGLTG-----------------------------------SIEVYDITTNKWEEMVEFPQERSSLSL 546
Cdd:COG3055   168 PDgKILVIGGRNGSGFSNtwttlaplptaraghaaavlggkilvfggesgfsdEVEAYDPATNTWTALGELPTPRHGHAA 247

                         250
                  ....*....|..
gi 1952522263 547 VTLSKCLYAIGG 558
Cdd:COG3055   248 VLTDGKVYVIGG 259
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-135 1.41e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 110.18  E-value: 1.41e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  17 TLLQeGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEV 96
Cdd:cd18255     4 TLLQ-GLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSEL 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1952522263  97 QLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNC 135
Cdd:cd18255    83 TLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-136 4.28e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 109.32  E-value: 4.28e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  14 YQQTLLQEgLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYS 93
Cdd:cd18270     9 YAVSLLEQ-LKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYT 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1952522263  94 SEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCL 136
Cdd:cd18270    88 GNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-138 8.84e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 108.92  E-value: 8.84e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  14 YQQTLLQEgLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLED-VEPEMVEVLLRYIY 92
Cdd:cd18267    23 YADSVLTH-LNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHDsIHPEVLELLLDYAY 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1952522263  93 SSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLAI 138
Cdd:cd18267   102 SSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 27-122 3.11e-26

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 102.81  E-value: 3.11e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  27 LENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDI 106
Cdd:cd18314     1 YNDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDL 80

                          90
                  ....*....|....*.
gi 1952522263 107 FTAANMFQIPSIFTVC 122
Cdd:cd18314    81 LMLASKYQVPDLEKLC 96
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-130 6.45e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 102.84  E-value: 6.45e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  26 LLENNKFVDCILKVKGK----EFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDN 101
Cdd:cd18248    15 LRLSQQLCDVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEFAYTASISVGEK 94

                          90       100
                  ....*....|....*....|....*....
gi 1952522263 102 NVQDIFTAANMFQIPSIFTVCISYLQKRL 130
Cdd:cd18248    95 CVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-136 2.89e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 100.99  E-value: 2.89e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  15 QQTLlqEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSS 94
Cdd:cd18249     8 RQTL--EAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTS 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1952522263  95 EVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCL 136
Cdd:cd18249    86 QITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCL 127
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-138 6.11e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 100.03  E-value: 6.11e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  21 EGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLND 100
Cdd:cd18306     7 AKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRLEVPA 86

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1952522263 101 NNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLAI 138
Cdd:cd18306    87 DLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 133-242 1.15e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 98.84  E-value: 1.15e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-ESHL 211
Cdd:cd18445     4 SNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDpENRK 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1952522263 212 KALPELFDCIRFLLMPKEYLKEHVEGNPTVK 242
Cdd:cd18445    84 EHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-136 1.46e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 99.32  E-value: 1.46e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  23 LRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLED-VEPEMVEVLLRYIYSSEVQLNDN 101
Cdd:cd18254    13 LNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDsLHPEVLELLLDFAYSSRIIINEE 92

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1952522263 102 NVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCL 136
Cdd:cd18254    93 NAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 127
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-138 2.71e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 98.19  E-value: 2.71e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  15 QQTLLQegLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSS 94
Cdd:cd18336     4 EQTFRK--MENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYTG 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1952522263  95 EVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLAI 138
Cdd:cd18336    82 VLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-138 5.07e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 98.04  E-value: 5.07e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  12 RIYQQTLLQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYI 91
Cdd:cd18272    12 RSHSSRVAQSIMDLCLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYI 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1952522263  92 YSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLAI 138
Cdd:cd18272    92 YHGTVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQV 138
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-130 9.04e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 96.45  E-value: 9.04e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  14 YQQTLLQeGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYS 93
Cdd:cd18257     1 HSEQLLQ-GLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYT 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1952522263  94 SEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRL 130
Cdd:cd18257    80 GTVFISQATVESLLPAANLLQIKLVLKECCDFLESQL 116
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-138 1.20e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 96.44  E-value: 1.20e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  23 LRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNN 102
Cdd:cd18271    15 LQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDDN 94

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1952522263 103 VQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLAI 138
Cdd:cd18271    95 VEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-136 1.84e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 96.05  E-value: 1.84e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  21 EGLRDLLENNKFVDCILK-VKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLN 99
Cdd:cd18252    10 DAFRTFYLDGLFTDITLQcASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICIT 89

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1952522263 100 DNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCL 136
Cdd:cd18252    90 ERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCL 126
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-126 7.96e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 93.84  E-value: 7.96e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  18 LLQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQ 97
Cdd:cd18287     8 FLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYTGRLT 87

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1952522263  98 L---NDNNVQDIFTAANMFQIPSIFTVCISYL 126
Cdd:cd18287    88 LtdlKEDVLLDVLGLAHQYGFEELEAAISDYL 119
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-130 3.07e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 92.48  E-value: 3.07e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  23 LRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNN 102
Cdd:cd18339    12 MNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEEN 91

                          90       100
                  ....*....|....*....|....*...
gi 1952522263 103 VQDIFTAANMFQIPSIFTVCISYLQKRL 130
Cdd:cd18339    92 VQVLLPAASLLQLMDVRQNCCDFLQSQL 119
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-134 5.85e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 91.44  E-value: 5.85e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  18 LLQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQ 97
Cdd:cd18279     4 RLAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAP 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1952522263  98 LNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSN 134
Cdd:cd18279    84 NLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-127 1.22e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 90.09  E-value: 1.22e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  18 LLQeGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDL--EESKKREITLEDVEPEMVEVLLRYIYSSE 95
Cdd:cd18245     1 LLR-ALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPpkDDGSTYKIELEGISVEVMEEILDYIYTGQ 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1952522263  96 VQLNDNNVQDIFTAANMFQIPSIFTVCISYLQ 127
Cdd:cd18245    80 IKLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-134 1.24e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 90.83  E-value: 1.24e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  19 LQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQL 98
Cdd:cd18343     8 LAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPN 87

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1952522263  99 NDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSN 134
Cdd:cd18343    88 LDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
436-604 1.51e-21

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 94.84  E-value: 1.51e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 436 WGESDPLPYEVYGHSVVSHNEKVYVIGGKGiAKKCLNKMCVYNPQRFEWKELAPM-KTARSLFGAIVHRDKIWVATGVT- 513
Cdd:COG3055     3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLS-GGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTg 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 514 ---DSGLTGSIEVYDITTNKWEEMVEFPQERSSLSLVTLSKCLYAIGGFAMmqteagdfvPTEINDIWKYDDEKEEWIgI 590
Cdd:COG3055    82 anpSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDD---------GGNVAWVEVYDPATGTWT-Q 151

                         170
                  ....*....|....*..
gi 1952522263 591 LREIP---YAATATFLP 604
Cdd:COG3055   152 LAPLPtprDHLAAAVLP 168
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-130 2.67e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 90.09  E-value: 2.67e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMF 113
Cdd:cd18246    41 DIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLPAASLL 120

                          90
                  ....*....|....*..
gi 1952522263 114 QIPSIFTVCISYLQKRL 130
Cdd:cd18246   121 QLNGVRDACCKFLLSQL 137
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-138 6.85e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 88.56  E-value: 6.85e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  23 LRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNN 102
Cdd:cd18335    10 MESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDT 89

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1952522263 103 VQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLAI 138
Cdd:cd18335    90 IENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 24-128 1.29e-20

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 87.70  E-value: 1.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  24 RDLLE---NNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQL-N 99
Cdd:cd18286     6 KDLLQlflNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLpD 85

                          90       100
                  ....*....|....*....|....*....
gi 1952522263 100 DNNVQDIFTAANMFQIPSIFTVCISYLQK 128
Cdd:cd18286    86 DVNLGELLSLADMYGLDGLKDVVAYTLRR 114
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-138 1.45e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 87.81  E-value: 1.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  23 LRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNN 102
Cdd:cd18337    14 MENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQYAYTGRLELKEDN 93

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1952522263 103 VQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLAI 138
Cdd:cd18337    94 IECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-126 4.92e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 85.84  E-value: 4.92e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  19 LQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIY------ 92
Cdd:cd18280     1 LGQHFGALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYkdelpd 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1952522263  93 ------SSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYL 126
Cdd:cd18280    81 dvepagSDSSSLDTTMAQHLLAAADRYALERLRLLCESRL 120
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-126 5.82e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 86.03  E-value: 5.82e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  14 YQQTLLqEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYS 93
Cdd:cd18251     6 HSQALL-DGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYT 84

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1952522263  94 SEVQLNDNNVQDIFTAANMFQIPSIFTVCISYL 126
Cdd:cd18251    85 SELELSLDNVQETLTAACQLQIPEVIGFCCDFL 117
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-136 7.56e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 85.79  E-value: 7.56e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  20 QEGLRDLLENNK---FVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEES---KKREITLEDVEPEMVEVLLRYIYS 93
Cdd:cd18258     2 KEMLKELNQQRRakeFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSgggEKLELTMSNINADVLELLLEFVYT 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1952522263  94 SEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCL 136
Cdd:cd18258    82 GSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCL 124
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-130 1.05e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 85.12  E-value: 1.05e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  23 LRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNN 102
Cdd:cd18338    12 MNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEEN 91

                          90       100
                  ....*....|....*....|....*...
gi 1952522263 103 VQDIFTAANMFQIPSIFTVCISYLQKRL 130
Cdd:cd18338    92 VQVLLPAAGLLQLQDVKKTCCEFLESQL 119
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 133-231 1.22e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 84.30  E-value: 1.22e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHEESHLK 212
Cdd:cd18444     5 SNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPERK 84

                          90       100
                  ....*....|....*....|
gi 1952522263 213 A-LPELFDCIRFLLMPKEYL 231
Cdd:cd18444    85 KhLAKLLALIRLPLLTPQFL 104
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
324-525 2.65e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 88.29  E-value: 2.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 324 AYDPTNNECYFASISSKIPKNHTSIVTKQNQIFVAGGlYYNEGDKENPLHSyFLQFDHLDCDWLGMPPLPSPRCLFGLGE 403
Cdd:COG3055    42 VYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGG-FTGANPSSTPLND-VYVYDPATNTWTKLAPMPTPRGGATALL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 404 AENAIYVIGGkevNEGEKTLDTVMCYD--------------------------------------RHTFKWGESDPLPYE 445
Cdd:COG3055   120 LDGKIYVVGG---WDDGGNVAWVEVYDpatgtwtqlaplptprdhlaaavlpdgkilviggrngsGFSNTWTTLAPLPTA 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 446 VYGHSVVSHNEKVYVIGGKGIAkkcLNKMCVYNPQRFEWKELAPMKTARSLFGAIVHRDKIWVATGVTDSG----LTGSI 521
Cdd:COG3055   197 RAGHAAAVLGGKILVFGGESGF---SDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGvrtpLVTSA 273


                  ....
gi 1952522263 522 EVYD 525
Cdd:COG3055   274 EVYD 277
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 32-115 3.79e-19

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 82.21  E-value: 3.79e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  32 FVDCILKVKGKEFPCHRLVLAACSPYFRAMFLsDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAAN 111
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLK-ETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79


                  ....
gi 1952522263 112 MFQI 115
Cdd:cd18315    80 LLQI 83
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-135 8.16e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 82.92  E-value: 8.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  16 QTLLQEGLrdllennkFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSE 95
Cdd:cd18264    20 QSLRAEGF--------LCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTSW 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1952522263  96 VQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNC 135
Cdd:cd18264    92 LSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 134-235 8.51e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 81.97  E-value: 8.51e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 134 NCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHEESHLK- 212
Cdd:cd18457     5 NCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRENREe 84

                          90       100
                  ....*....|....*....|...
gi 1952522263 213 ALPELFDCIRFLLMPKEYLKEHV 235
Cdd:cd18457    85 YLPELLSKVRLPLLRPQFLTDRV 107
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 32-122 9.26e-19

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 82.34  E-value: 9.26e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  32 FVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKR-----EITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDI 106
Cdd:cd18296    17 FPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENngsipVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDV 96

                          90
                  ....*....|....*.
gi 1952522263 107 FTAANMFQIPSIFTVC 122
Cdd:cd18296    97 LYVADMYLLPGLKRLC 112
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-134 1.97e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 81.69  E-value: 1.97e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  19 LQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQL 98
Cdd:cd18342     9 LADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPN 88

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1952522263  99 NDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSN 134
Cdd:cd18342    89 LDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 124
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 133-244 2.13e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 81.65  E-value: 2.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-ESHL 211
Cdd:cd18513     4 TNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDkEARL 83

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1952522263 212 KALPELFDCIRFLLMPKEYLKEHVEGNPTVKSS 244
Cdd:cd18513    84 EHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNN 116
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-126 2.20e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 80.75  E-value: 2.20e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  19 LQEGLRDLLENNKFVDCILKV--KGKEFPCHRLVLAACSPYFRAMFLSDL-EESKKREITLEDVEPEMVEVLLRYIYSSE 95
Cdd:cd18294     1 FAADMKSLINNPEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTGPqKESTQSPLVLSDIEPEVFRAVLEFIYTNC 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1952522263  96 VQLNDNNVQDIFTAANMFQIPSIFTVCISYL 126
Cdd:cd18294    81 VTLSNHTVIEVLAAAVEYGLDELRKLCERFI 111
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-134 7.65e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 79.89  E-value: 7.65e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  19 LQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQL 98
Cdd:cd18345     5 LSDDLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKAPN 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1952522263  99 NDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSN 134
Cdd:cd18345    85 LDKMADDLLAAADKYALERLKVMCEEALCSNLSVEN 120
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-134 2.69e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 78.46  E-value: 2.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  18 LLQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEV- 96
Cdd:cd18344     9 MLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGKAp 88

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1952522263  97 QLNDNNVQ-DIFTAANMFQIPSIFTVCISYLQKRLGLSN 134
Cdd:cd18344    89 HLHSHSMAcDVLAAADKYGLEGLKVLCEDALCRNLSVEN 127
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 133-223 2.84e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 77.35  E-value: 2.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-ESHL 211
Cdd:cd18448     5 SNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDpQHRK 84

                          90
                  ....*....|..
gi 1952522263 212 KALPELFDCIRF 223
Cdd:cd18448    85 RHLDDLLSQVRL 96
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 133-244 5.74e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 77.76  E-value: 5.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-ESHL 211
Cdd:cd18512     4 TNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDkEVRQ 83

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1952522263 212 KALPELFDCIRFLLMPKEYLKEHVEGNPTVKSS 244
Cdd:cd18512    84 EHMAHLMEHVRLPLLSREYLVQRVEEETLVKNS 116
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 35-113 6.10e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 75.78  E-value: 6.10e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1952522263  35 CILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMF 113
Cdd:cd01165     1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-127 9.26e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 76.44  E-value: 9.26e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMF 113
Cdd:cd18198    27 DVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFAYTATLTVSTANVGDILSAARLL 106

                          90
                  ....*....|....
gi 1952522263 114 QIPSIFTVCISYLQ 127
Cdd:cd18198   107 EIPCVSHVCAEILD 120
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 21-137 1.40e-16

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 76.00  E-value: 1.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  21 EGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLND 100
Cdd:cd18263     2 QSIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSW 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1952522263 101 NNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLA 137
Cdd:cd18263    82 ENLFEATCTALQLQISGALALCLDFLQREISPARCLD 118
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-135 1.52e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 75.82  E-value: 1.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  24 RDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDleeskKREITLEDVEPEMVEVLLRYIYSSEVQLN--DN 101
Cdd:cd18303    10 ASLFDKELYSDITIKLADKSIPAHKFVLAARSEKWSNENLAS-----TNELDLSDISYEVVLALLRWLYTDELDLTldDE 84

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1952522263 102 NVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNC 135
Cdd:cd18303    85 FLLELMKAAKRFQLTDLVERCERALMSSVNVDNC 118
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 130-206 2.80e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 73.90  E-value: 2.80e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1952522263 130 LGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAH 206
Cdd:cd18480     1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKH 77
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-130 3.01e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 74.74  E-value: 3.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  45 PCHRLVLAACSPYFRAMFLSDLEESKKrEITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTVCIS 124
Cdd:cd18282    24 PAHKYVLATGSSVFYAMFYGGLAENKN-EIEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLARACVQ 102


                  ....*.
gi 1952522263 125 YLQKRL 130
Cdd:cd18282   103 FLETSL 108
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-127 4.21e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 74.92  E-value: 4.21e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  22 GLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDN 101
Cdd:cd18328    15 SLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILEFAYTSTLTITTS 94

                          90       100
                  ....*....|....*....|....*.
gi 1952522263 102 NVQDIFTAANMFQIPSIFTVCISYLQ 127
Cdd:cd18328    95 NVKHILNAAQMLEIQCIINVCLEIMD 120
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-126 6.33e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 74.20  E-value: 6.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  22 GLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDN 101
Cdd:cd18326    15 SLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFAYTATLTVSTS 94

                          90       100
                  ....*....|....*....|....*
gi 1952522263 102 NVQDIFTAANMFQIPSIFTVCISYL 126
Cdd:cd18326    95 NVGDILSAARLLEIPAVSHVCADLL 119
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 133-233 6.88e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 73.80  E-value: 6.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-ESHL 211
Cdd:cd18510     5 SNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDlQNRQ 84

                          90       100
                  ....*....|....*....|..
gi 1952522263 212 KALPELFDCIRFLLMPKEYLKE 233
Cdd:cd18510    85 KDLGMLLSYIRLPLLPPQLLAD 106
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 133-230 7.29e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 73.64  E-value: 7.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHEE-SHL 211
Cdd:cd18469     6 TNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPqARA 85

                          90
                  ....*....|....*....
gi 1952522263 212 KALPELFDCIRFLLMPKEY 230
Cdd:cd18469    86 AHLPELLSLVHLSLLTDQY 104
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 133-210 8.06e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 73.10  E-value: 8.06e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHEESH 210
Cdd:cd18458     5 SNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEEN 82
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-135 8.73e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 74.07  E-value: 8.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  44 FPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTVCI 123
Cdd:cd18239    37 FPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCK 116

                          90
                  ....*....|..
gi 1952522263 124 SYLQKRLGLSNC 135
Cdd:cd18239   117 VLLISGVTLENC 128
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-125 1.49e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 73.09  E-value: 1.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  16 QTLLQEgLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSD-LEESKKREITL-EDVEPEMV-EVLLRYIY 92
Cdd:cd18292     2 REFLQD-IAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDwWSESKQSEIELvEDPECAAVfEKFLRYLY 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1952522263  93 SSEVQLNDNNVQDIFTAANMFQIPSIFTVCISY 125
Cdd:cd18292    81 TGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-138 1.91e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 73.45  E-value: 1.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  22 GLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDN 101
Cdd:cd18244    20 GFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSML 99

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1952522263 102 NVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLAI 138
Cdd:cd18244   100 TVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEI 136
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-134 2.21e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 72.85  E-value: 2.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  42 KEFPCHRLVLAACSPYFRAMFLSDLEeSKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTV 121
Cdd:cd18281    36 QRIPAHKFVLSIGSAVFDAMFNGGMA-TTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESA 114

                          90
                  ....*....|...
gi 1952522263 122 CISYLQKRLGLSN 134
Cdd:cd18281   115 CVEFLKKNLSSDN 127
PHA02713 PHA02713
hypothetical protein; Provisional
 23-532 2.66e-15

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 78.90  E-value: 2.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  23 LRDLLENNKFVDCILKVK-GKEFPCHRLVLAACSPYFRAMFLSDL-EESKKREITLEDVEPEMVEVLLRYIYSSEVqlND 100
Cdd:PHA02713   16 ISNLLDDDILCDVIITIGdGEEIKAHKTILAAGSKYFRTLFTTPMiIRDLVTRVNLQMFDKDAVKNIVQYLYNRHI--SS 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 101 NNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLAIF-RLGLMLDCPRLAVGARDFVCDHFNLISKDQdfLQLSPSEI 179
Cdd:PHA02713   94 MNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMYhRLYEMSHIPIVKYIKRMLMSNIPTLITTDA--FKKTVFEI 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 180 I--AIVASDSLNVEKEEAVFEAVMSWAAHEESHLKALPELFDCIRFLLMPKEYlKEHVEGNPTVKSSPELlkkIQLVKDA 257
Cdd:PHA02713  172 LfdIISTNDNVYLYREGYKVTILLKWLEYNYITEEQLLCILSCIDIQNLDKKS-RLLLYSNKTINMYPSC---IQFLLDN 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 258 QEGKGpfaktkkekavavktksgedavggeakeaeeeLVPgilnenLRFGMFVKDLIFMINDEATVAYDPTNNEcyfASI 337
Cdd:PHA02713  248 KQNRN--------------------------------IIP------RQLCLVCHDTKYNVCNPCILVYNINTME---YSV 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 338 SSKIPK---NHTSIVTkQNQIFVAGGLYYNegdkeNPLHS--YFLQFDHLDCdwLGMPPLPSPRCLFGLGEAENAIYVIG 412
Cdd:PHA02713  287 ISTIPNhiiNYASAIV-DNEIIIAGGYNFN-----NPSLNkvYKINIENKIH--VELPPMIKNRCRFSLAVIDDTIYAIG 358

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 413 GKEVNEGEKTLDtvmCYDRHTFKWGESDPLPYEVYGHSVVSHNEKVYVIGGKG-----------------IAKKCLNKMC 475
Cdd:PHA02713  359 GQNGTNVERTIE---CYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTehidytsvhhmnsidmeEDTHSSNKVI 435

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1952522263 476 VYNPQRFEWKELAPMKTARSLFGAIVHRDKIWVATGVTD-SGLTGSIEVYDITT-NKWE 532
Cdd:PHA02713  436 RYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVVCDIKDeKNVKTCIFRYNTNTyNGWE 494
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 133-231 4.07e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 71.29  E-value: 4.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHEESHLK 212
Cdd:cd18468     3 SNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKNRK 82

                          90       100
                  ....*....|....*....|
gi 1952522263 213 A-LPELFDCIRFLLMPKEYL 231
Cdd:cd18468    83 QhIAELLAVVRLPFIHPSYL 102
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 130-226 4.69e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 71.13  E-value: 4.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 130 LGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-E 208
Cdd:cd18467     1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDvQ 80

                          90
                  ....*....|....*...
gi 1952522263 209 SHLKALPELFDCIRFLLM 226
Cdd:cd18467    81 ERQKYLAQLLHCVRLPLL 98
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-129 9.00e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 70.72  E-value: 9.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  12 RIYQQTLLQEGLRDllennkfVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDlEESKKREITLEDVEPEMVEVLLRYI 91
Cdd:cd18231     3 RLNEQRLFQPDLCD-------VDIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALTSQGLQQILNFI 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1952522263  92 YSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKR 129
Cdd:cd18231    75 YTSKLLVNSCNVQDVLNAAAVLQMNDIAASCQELIDSR 112
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-130 9.38e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 70.40  E-value: 9.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  42 KEFPCHRLVLAACSPYFRAMFLSDLEESKKrEITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTV 121
Cdd:cd18349    22 QRVPAHKYVLAVGSSVFYAMFYGDLAEVKS-EIHIPDVEPAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPALAKA 100


                  ....*....
gi 1952522263 122 CISYLQKRL 130
Cdd:cd18349   101 CVNFLETSL 109
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 133-207 9.82e-15

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 69.36  E-value: 9.82e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE 207
Cdd:cd18508     3 TNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 133-246 1.42e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 70.89  E-value: 1.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAH-EESHL 211
Cdd:cd18452     4 SNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHdKEERE 83

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1952522263 212 KALPELFDCIRFLLMPKEYLKEHVEGNPTVKSSPE 246
Cdd:cd18452    84 DYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLE 118
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 129-206 1.46e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 68.96  E-value: 1.46e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952522263 129 RLGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAH 206
Cdd:cd18463     1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-136 1.49e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 70.23  E-value: 1.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  19 LQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDleESKKReITLEDVEPEMVEVLLRYIYSSEVQL 98
Cdd:cd18260     5 LLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKD--PSLQR-VELNDISPLGLATVITYAYTGKLTL 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1952522263  99 NDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCL 136
Cdd:cd18260    82 SLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-123 1.64e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 70.20  E-value: 1.64e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  32 FVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLE-ESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAA 110
Cdd:cd18293    15 FCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPpAGQKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLAAA 94

                          90
                  ....*....|...
gi 1952522263 111 NMFQIPSIFTVCI 123
Cdd:cd18293    95 RRLQISELESLCL 107
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-134 2.21e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 70.07  E-value: 2.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  19 LQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFlsdleesKKREITLEDVEPEMVEVLLRYIYSSEVQL 98
Cdd:cd18243    19 LLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF-------SINNLVLQGCSSIGLRLVLEYLYTANVTL 91

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1952522263  99 NDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSN 134
Cdd:cd18243    92 SLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 133-233 2.24e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 69.32  E-value: 2.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-ESHL 211
Cdd:cd18511     5 SNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDvEQRR 84

                          90       100
                  ....*....|....*....|..
gi 1952522263 212 KALPELFDCIRFLLMPKEYLKE 233
Cdd:cd18511    85 KDLSKLLAYIRLPLLAPQFLAD 106
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-126 2.55e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 69.37  E-value: 2.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  14 YQQTLLQEgLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREI-TLEDVEPEMVEVLLRYIY 92
Cdd:cd18199     1 HQSRLLGQ-LNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTaSFDVFSSDAFSIILDFVY 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1952522263  93 SSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYL 126
Cdd:cd18199    80 SGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-134 2.72e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 69.61  E-value: 2.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  25 DLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNN-- 102
Cdd:cd18297     5 HYVNNPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVESLDVAqd 84

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1952522263 103 -VQDIFTAANMFQIPSIFTVCISYLQKRLGLSN 134
Cdd:cd18297    85 dALELLRAASFFQLDGLKRHCEILLSQQIDLDN 117
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 134-223 2.92e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 68.73  E-value: 2.92e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 134 NCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHEESHLKA 213
Cdd:cd18483     5 NSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQSKREM 84

                          90
                  ....*....|..
gi 1952522263 214 -LPELF-DCIRF 223
Cdd:cd18483    85 hLPEIFaKCIRM 96
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-135 3.05e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 69.89  E-value: 3.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  41 GKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLED------VEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMFQ 114
Cdd:cd18241    35 GREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKwssepgPDPDTVEAVIQYMYTGRIRVSTGNVHEVLELADRFL 114

                          90       100
                  ....*....|....*....|.
gi 1952522263 115 IPSIFTVCISYLQKRLGLSNC 135
Cdd:cd18241   115 LIRLKEFCGEFLKKKLNLSNC 135
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-136 3.12e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 69.92  E-value: 3.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  15 QQTLLQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSS 94
Cdd:cd18266     8 HSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVIDFLYSS 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1952522263  95 EVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCL 136
Cdd:cd18266    88 ELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYL 129
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-130 3.71e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 69.50  E-value: 3.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  23 LRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEEskkREITLEDVEPEMVEV----------LLRYIY 92
Cdd:cd18228    10 LNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASP---RLVLVSPAGKCVLDLhhvtvtgfapLLEYAY 86

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1952522263  93 SSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRL 130
Cdd:cd18228    87 TSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 134-214 5.11e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 68.11  E-value: 5.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 134 NCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHEE----S 209
Cdd:cd18455     4 NCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPeerkV 83


                  ....*
gi 1952522263 210 HLKAL 214
Cdd:cd18455    84 HLKDL 88
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-129 9.46e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 68.32  E-value: 9.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  14 YQQTLLQEgLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRaMFLSdlEESKKREITL---EDVEPEMVEVLLRY 90
Cdd:cd18323     6 HSRHLLQS-LREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFH-MFYK--EQLDKRDLVCinnEIVTAPAFSLLLEF 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1952522263  91 IYSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKR 129
Cdd:cd18323    82 MYEGRLSFNDTPVEDVLAAASYLHMNDIVKVCKKRLQAR 120
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 133-233 1.06e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 67.35  E-value: 1.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-ESHL 211
Cdd:cd18509     5 SNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDmQRRC 84

                          90       100
                  ....*....|....*....|..
gi 1952522263 212 KALPELFDCIRFLLMPKEYLKE 233
Cdd:cd18509    85 SDLSMLLAYIRLPLLPPQLLAD 106
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-126 1.18e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 67.54  E-value: 1.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  13 IYQQTLLQEgLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEE-SKKREITLEDVEPEMVEVLLRYI 91
Cdd:cd18329     3 SHQSRLLQQ-LDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKEtGQPTVATFDVFSPDTFTIILDFV 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1952522263  92 YSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYL 126
Cdd:cd18329    82 YSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-136 1.69e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 67.68  E-value: 1.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMF 113
Cdd:cd18261    30 DITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYTGQILLEPGVIQDVLAAGSHL 109

                          90       100
                  ....*....|....*....|...
gi 1952522263 114 QIPSIFTVCISYLQKRLGLSNCL 136
Cdd:cd18261   110 QLLELLSLCSHYLIQELNSFNYL 132
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 130-207 1.84e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 65.71  E-value: 1.84e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1952522263 130 LGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKD-QDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE 207
Cdd:cd18450     1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKDsEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 133-208 1.89e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 66.61  E-value: 1.89e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHEE 208
Cdd:cd18447     5 SNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-134 2.12e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 67.39  E-value: 2.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  42 KEFPCHRLVLAACSPYFRAMFLSDLEESKKrEITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTV 121
Cdd:cd18346    42 QRIPAHRFVLAAGSAVFDAMFNGGMATTSA-EIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAH 120

                          90
                  ....*....|...
gi 1952522263 122 CISYLQKRLGLSN 134
Cdd:cd18346   121 CVEFLTKHLRADN 133
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 133-230 2.92e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 66.18  E-value: 2.92e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-ESHL 211
Cdd:cd18456     4 SNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDvDGRR 83

                          90
                  ....*....|....*....
gi 1952522263 212 KALPELFDCIRFLLMPKEY 230
Cdd:cd18456    84 QHVPRLMKCVRLPLLSRDF 102
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-127 3.18e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 66.79  E-value: 3.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMF------LSDLEESKKREI-TLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDI 106
Cdd:cd18327    27 DLTIKTRGLEYRTHRAVLAACSLYFRKLFtgggggSGDLGAGGGQDVcELDFVGPEALGALLEFAYTATLTISSSNMREV 106

                          90       100
                  ....*....|....*....|.
gi 1952522263 107 FTAANMFQIPSIFTVCISYLQ 127
Cdd:cd18327   107 LRAARLLEIPCVADACADILQ 127
PHA02790 PHA02790
Kelch-like protein; Provisional
 13-531 3.62e-13

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 72.00  E-value: 3.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  13 IYQQTLLQEGLRDLLENNKFvDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKK--REITLeDVEPEMVEVLLRY 90
Cdd:PHA02790    3 IFVNTVYCKNILALSMTKKF-KTIIEAIGGNIIVNSTILKKLSPYFRTHLRQKYTKNKDpvTRVCL-DLDIHSLTSIVIY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  91 IYSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKD-- 168
Cdd:PHA02790   81 SYTGKVYIDSHNVVNLLRASILTSVEFIIYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLELEDDii 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 169 QDFLQLSpseIIAIVASDSLNVEKEEAVFEAVMSWAAHEESHLKALpelfdcirfLLMPKEYLKEHV---EGNPTVKSSP 245
Cdd:PHA02790  161 DNFDYLS---MKLILESDELNVPDEDYVVDFVIKWYMKRRNRLGNL---------LLLIKNVIRSNYlspRGINNVKWIL 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 246 ELLKKIQLVKDAQEG-KGPFAKTKKEK-------AVAVKTKSGEdavggeakeaEEELVPGILNENlrfgmfvkdlifmI 317
Cdd:PHA02790  229 DCTKIFHCDKQPRKSyKYPFIEYPMNMdqiidifHMCTSTHVGE----------VVYLIGGWMNNE-------------I 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 318 NDEATVAYDPTNNECYFASISSkiPKNHTSIVTKQNQIFVAGGLyynegdkenPLHSYFLQFDHLDCDWLGMPPLPSPRC 397
Cdd:PHA02790  286 HNNAIAVNYISNNWIPIPPMNS--PRLYASGVPANNKLYVVGGL---------PNPTSVERWFHGDAAWVNMPSLLKPRC 354

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 398 LFGLGEAENAIYVIGGKevNEGEKTLDTVMCyDRHTFKWGESDPLPYevYGHSVVSHNEKVYVIGgkgiakKCLNKMCVY 477
Cdd:PHA02790  355 NPAVASINNVIYVIGGH--SETDTTTEYLLP-NHDQWQFGPSTYYPH--YKSCALVFGRRLFLVG------RNAEFYCES 423

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1952522263 478 NPQrfeWKELAPMKTARSLFGAIVHRDKIWVATGVTDSGLTGSIEVYDITTNKW 531
Cdd:PHA02790  424 SNT---WTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSW 474
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 19-94 6.85e-13

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 65.00  E-value: 6.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  19 LQEGLRDLL----ENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEES----KKREITLEDVEPEMVEVLLRY 90
Cdd:cd18301     1 FQEDFKKLLdeadEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSedavGCDVVHIEKVPPEIFEQLLQF 80


                  ....
gi 1952522263  91 IYSS 94
Cdd:cd18301    81 IYTD 84
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-126 9.10e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 64.95  E-value: 9.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  14 YQQTLLQEgLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREI-TLEDVEPEMVEVLLRYIY 92
Cdd:cd18330     1 YYTKLLGE-LNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTaSLDIVTSEAFSIILDFLY 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1952522263  93 SSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYL 126
Cdd:cd18330    80 SGKLDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 130-208 9.67e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 63.68  E-value: 9.67e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1952522263 130 LGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHEE 208
Cdd:cd18474     1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-130 9.91e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 65.23  E-value: 9.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  14 YQQTLLQeGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRaMFLSDLEEskKREITL---EDVEPEMVEVLLRY 90
Cdd:cd18194     6 HSRQLLQ-CLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFH-LFYRDRLD--KRDLVRlnsDIVTAPAFGLLLDF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1952522263  91 IYSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRL 130
Cdd:cd18194    82 MYEGRLALRDLPVEDVLAAASYLHMYDIVKVCKGRLQEKA 121
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 134-222 1.00e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 64.31  E-value: 1.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 134 NCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-ESHLK 212
Cdd:cd18479     5 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNtESRSQ 84

                          90
                  ....*....|
gi 1952522263 213 ALPELFDCIR 222
Cdd:cd18479    85 YLSSVLSQIR 94
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 133-204 1.33e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 63.18  E-value: 1.33e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWA 204
Cdd:cd18472     4 ANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-125 1.53e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 63.67  E-value: 1.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  32 FVDCILKVKGKEFPCHRLVLAACSPYFRAMFLS-DLEESKKREITL--EDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFT 108
Cdd:cd18307     1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSnDMKATDELSITIdcDYLSPETVEQLLDYFYTGKIVISEKNVEDLLK 80

                          90
                  ....*....|....*..
gi 1952522263 109 AANMFQIPSIFTVCISY 125
Cdd:cd18307    81 GAKYFNIPRLKDHCVDF 97
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 133-227 2.15e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 63.29  E-value: 2.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-ESHL 211
Cdd:cd18464     3 SNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDlPRRH 82

                          90
                  ....*....|....*.
gi 1952522263 212 KALPELFDCIRFLLMP 227
Cdd:cd18464    83 EVLPELLRSVRLALLP 98
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-129 4.52e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 63.53  E-value: 4.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263   7 PAEEPRIYQQTLLQEglrdllENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITL--EDVEPEMV 84
Cdd:cd18196     2 PGHFEQIFQQLNYQR------LHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLdsEVVTAEAF 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1952522263  85 EVLLRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKR 129
Cdd:cd18196    76 AALIDMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTR 120
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 24-130 5.87e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 62.64  E-value: 5.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  24 RDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNN- 102
Cdd:cd18300     1 KLFLNKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEDGd 80

                          90       100
                  ....*....|....*....|....*...
gi 1952522263 103 VQDIFTAANMFQIPSIFTVCISYLQKRL 130
Cdd:cd18300    81 CVGLIVLANRLCLPRLVALCEQYIVKEL 108
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-127 6.16e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 62.60  E-value: 6.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLSdlEESKKREITLEDVEP-EMVEVLLRYIYSSEVQLNDNNVQDIFTAANM 112
Cdd:cd18233    20 DCMLVVKGVCFKAHKNVLAAFSQYFRSLFQN--SSSQKNDVFHLDIKNvGGIGQILDFMYTSHLDLNQDNVQVMLDIAQC 97

                          90
                  ....*....|....*
gi 1952522263 113 FQIPSIFTVCISYLQ 127
Cdd:cd18233    98 LQVQNVLNMCYTFLK 112
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 134-236 9.15e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 62.10  E-value: 9.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 134 NCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHEES-HLK 212
Cdd:cd18446     5 NCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKESeRLP 84

                          90       100
                  ....*....|....*....|....
gi 1952522263 213 ALPELFDCIRFLLMPKEYLKEHVE 236
Cdd:cd18446    85 LLPRVLENVRLPLLDPWYFVETVE 108
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-122 1.04e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 62.29  E-value: 1.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  31 KFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEE-SKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTA 109
Cdd:cd18207    26 RFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDgGTPRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTA 105

                          90
                  ....*....|...
gi 1952522263 110 ANMFQIPSIFTVC 122
Cdd:cd18207   106 AKFLLMRSVIDIC 118
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 130-222 1.26e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 61.29  E-value: 1.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 130 LGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-E 208
Cdd:cd18462     1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDvE 80

                          90
                  ....*....|....
gi 1952522263 209 SHLKALPELFDCIR 222
Cdd:cd18462    81 KRIECAYDLLSSIK 94
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 133-227 1.27e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 61.40  E-value: 1.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHEESHLK 212
Cdd:cd18514     4 SNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLEKRK 83

                          90
                  ....*....|....*.
gi 1952522263 213 A-LPELFDCIRFLLMP 227
Cdd:cd18514    84 DyLPELLRNVRLALLP 99
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-122 1.31e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 61.87  E-value: 1.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLsdleeSKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMF 113
Cdd:cd18206    24 DCTFVVDGVDFKAHKAVLAACSEYFRMLFV-----DQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFL 98


                  ....*....
gi 1952522263 114 QIPSIFTVC 122
Cdd:cd18206    99 QMQDIVTAC 107
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 21-126 2.42e-11

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 60.69  E-value: 2.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  21 EGLRDLLENNKFVDCILKVKGKE-FPCHRLVLAACSPYFRAMFLSdleeskKREITLE-DVEPEMVEVLLRYIYSSEVQL 98
Cdd:cd18299     1 EDLRNLLHSPSCADVVFILQGGVrIFAHRIVLAAASSVFADLFLM------MTVVTLDsDITPEAFRRVLEFLYTGVLDE 74

                          90       100
                  ....*....|....*....|....*...
gi 1952522263  99 NDNNVQDIFTAANMFQIPSIFTVCISYL 126
Cdd:cd18299    75 NEDDLKELKDAAELLELFDLVMMCTNVL 102
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 133-227 4.52e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 59.60  E-value: 4.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-ESHL 211
Cdd:cd18515     3 TNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDlKKRH 82

                          90
                  ....*....|....*.
gi 1952522263 212 KALPELFDCIRFLLMP 227
Cdd:cd18515    83 CYLSELLQTVRLALLP 98
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-134 4.61e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 60.47  E-value: 4.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  42 KEFPCHRLVLAACSPYFRAMFLSDLEESKKrEITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTV 121
Cdd:cd18347    36 QRIPAHRFVLAVGSAVFDAMFNGGMATTST-EIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAH 114

                          90
                  ....*....|...
gi 1952522263 122 CISYLQKRLGLSN 134
Cdd:cd18347   115 CVEFLKKNLRADN 127
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-134 5.48e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 60.42  E-value: 5.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  42 KEFPCHRLVLAACSPYFRAMFLSDLEESKKrEITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTV 121
Cdd:cd18348    35 QRLPGHKYVLAVGSSVFHAMFYGELAEDKD-EIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARA 113

                          90
                  ....*....|...
gi 1952522263 122 CISYLQKRLGLSN 134
Cdd:cd18348   114 CVNFLETSLSAKN 126
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 133-222 7.17e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 58.98  E-value: 7.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLnVEKEEAVFEAVMSWAAHEESHLK 212
Cdd:cd18476     4 SNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPKARK 82

                          90
                  ....*....|.
gi 1952522263 213 -ALPELFDCIR 222
Cdd:cd18476    83 gYIHDLFKKVR 93
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 133-225 9.57e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 58.97  E-value: 9.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-ESHL 211
Cdd:cd18485     4 SNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNrKSRV 83

                          90
                  ....*....|....
gi 1952522263 212 KALPELFDCIRFLL 225
Cdd:cd18485    84 QHLVELLKQVRLEL 97
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-122 1.57e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 58.83  E-value: 1.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  13 IYQqTLLQEGlrdllENNKFVDCILkvkGKEFPCHRLVLAACsPYFRAMFLSDLEESKKREITLE----DVEPEMVEVLL 88
Cdd:cd18305     5 IYQ-TLFLNG-----ENSDITICAL---GREWKLHKIYLCQS-GYFASMFSGSWKESKETVINLEipddNITVEALNVVF 74

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1952522263  89 RYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTVC 122
Cdd:cd18305    75 GSLYRDEIEIKPSRVVSILAAATLLQLDGLIQQC 108
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-122 1.59e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 58.61  E-value: 1.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  18 LLQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFlsdlEESKKREITL--EDVEPEMVEVLLRYIYSSE 95
Cdd:cd18217     4 QLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQY----KDTEDNIVFLdqSQVSADGFQKLLEFIYTGN 79

                          90       100
                  ....*....|....*....|....*..
gi 1952522263  96 VQLNDNNVQDIFTAANMFQIPSIFTVC 122
Cdd:cd18217    80 LNLDSWNVAEIHQAASYLGMEEVVAKC 106
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 18-106 1.69e-10

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 58.80  E-value: 1.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  18 LLQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFlsdleESK---KREITLED--VEPEMVEVLLRYIY 92
Cdd:cd18295     5 YYDEFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMF-----ETKwkdKREINLKHplVNPDAFRALLQYLY 79

                          90
                  ....*....|....
gi 1952522263  93 SSEVQLNDNNVQDI 106
Cdd:cd18295    80 TGRLEIHVDDVEDC 93
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 36-134 1.84e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 58.53  E-value: 1.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  36 ILKVKGKEFPCHRLVLAACSPYFRAMFLSD-LEESKKREITLEdVEPEMVEVLLRYIYSSEVQ-----LNDNNVQDIFTA 109
Cdd:cd18302    10 IVSEDGKEFPCHKCVLVARLEYFHSMLSSSwIEASSCSALTMP-IPSDILEIILDYLYTDEASavkesQNVEFLCNVLVI 88

                          90       100
                  ....*....|....*....|....*
gi 1952522263 110 ANMFQIPSIFTVCISYLQKRLGLSN 134
Cdd:cd18302    89 ADQLLITRLKEICEVALVELLSLKN 113
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 133-231 2.68e-10

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 57.49  E-value: 2.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHEESHLK 212
Cdd:cd18466     4 ANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKRK 83

                          90       100
                  ....*....|....*....|
gi 1952522263 213 A-LPELFDCIRFLLMPKEYL 231
Cdd:cd18466    84 KhVVEVLEPVRFPLLPPQRL 103
Kelch_6 pfam13964
Kelch motif;
448-494 3.83e-10

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 55.42  E-value: 3.83e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1952522263 448 GHSVVSHNEKVYVIGGKGIAKKCLNKMCVYNPQRFEWKELAPMKTAR 494
Cdd:pfam13964   4 FHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 133-226 7.72e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 56.28  E-value: 7.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 133 SNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHEESHLK 212
Cdd:cd18459     5 SNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQERR 84

                          90
                  ....*....|....*
gi 1952522263 213 A-LPELFDCIRFLLM 226
Cdd:cd18459    85 PhLPQVLQHVRLPLL 99
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 132-185 1.05e-09

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 54.20  E-value: 1.05e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1952522263 132 LSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVAS 185
Cdd:cd14733     2 PENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-126 1.07e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 56.49  E-value: 1.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263   7 PAEEPR-IYQQTL----LQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEE----SKKREITLE 77
Cdd:cd18278     1 KTESPMyVYESTVhctnILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENdlvvSLPEEVTAR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1952522263  78 DVEPemvevLLRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYL 126
Cdd:cd18278    81 GFGP-----LLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 29-122 1.44e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 55.95  E-value: 1.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  29 NNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFT 108
Cdd:cd18352    10 NATLSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLR 89

                          90
                  ....*....|....
gi 1952522263 109 AANMFQIPSIFTVC 122
Cdd:cd18352    90 AADQYLLEGLKRLC 103
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-133 1.60e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 56.22  E-value: 1.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  14 YQQtLLQEgLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIT-LEDVEPEMVEVLLRYIY 92
Cdd:cd18230     5 YRH-LLRE-LNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVThLDIVTAQGFKAIIDFMY 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1952522263  93 SSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRLGLS 133
Cdd:cd18230    83 SAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDIS 123
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-126 1.91e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 55.84  E-value: 1.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  23 LRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFL----SDLEESKKREITLEDVEPemvevLLRYIYSSEVQL 98
Cdd:cd18277    18 LNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVgqadAELNITLPEEVTVKGFEP-----LIQFAYTAKLIL 92

                          90       100
                  ....*....|....*....|....*...
gi 1952522263  99 NDNNVQDIFTAANMFQIPSIFTVCISYL 126
Cdd:cd18277    93 SKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-125 2.41e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 55.15  E-value: 2.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  28 ENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFlsdlEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIF 107
Cdd:cd18232    14 EEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLY----GDGTSGSVVLPESFAEVFGLLLDFFYTGELALTRENRDRVL 89

                          90
                  ....*....|....*...
gi 1952522263 108 TAANMFQIPSIFTVCISY 125
Cdd:cd18232    90 LAAKELRVPEAVELCQRF 107
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-122 2.45e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 55.26  E-value: 2.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  16 QTLLQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFlsdlEESKKREITLEDV----EPEMVEVLLRYI 91
Cdd:cd18215     3 ASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIF----TDQLKNNVSVINLdpeiEPEGFRILLDFM 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1952522263  92 YSSEVQLNDNNVQDIFTAANMFQIPSIFTVC 122
Cdd:cd18215    79 YTSRLNLREGNIMAVMATAMYLQMEHVVDTC 109
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 130-222 3.20e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 54.42  E-value: 3.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 130 LGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHEES 209
Cdd:cd18460     1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                          90
                  ....*....|....
gi 1952522263 210 HLKAL-PELFDCIR 222
Cdd:cd18460    81 HRQHFwPELLQHVR 94
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 17-96 3.55e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 55.09  E-value: 3.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  17 TLLQEGLRDLLEN--NKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEP--EMVEVLLRYIY 92
Cdd:cd18309     3 TTLEQDMEAFLESvgGDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPsrQAFDSLLRYIY 82


                  ....
gi 1952522263  93 SSEV 96
Cdd:cd18309    83 YGDV 86
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-126 3.58e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 54.01  E-value: 3.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFL----SDLEESKKREITLEDVEPemvevLLRYIYSSEVQLNDNNVQDIFTA 109
Cdd:cd18955     3 DVTIVVEDQRFRAHRAVLAACSDYFLSRVVgqtdGDLVITLPEEVTVKGFEP-----LLQFAYTAKLLLSKENVLEVCRC 77

                          90
                  ....*....|....*..
gi 1952522263 110 ANMFQIPSIFTVCISYL 126
Cdd:cd18955    78 AEFLGVHNIEKACFDFL 94
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-126 3.66e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 54.88  E-value: 3.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  26 LLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLsdLEESKKREITLEDvEPEMVEVLLRYIYSSEVQLNDNNVQD 105
Cdd:cd18197    19 LRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFL--LNQSKQVRITILQ-SAEVGRKLLLSCYTGALEVKKKELLK 95

                          90       100
                  ....*....|....*....|.
gi 1952522263 106 IFTAANMFQIPSIFTVCISYL 126
Cdd:cd18197    96 YLTAASYLQMVHIVEKCTEAL 116
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-127 5.28e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 54.65  E-value: 5.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  14 YQQTLLQEgLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMflSDLEESKKREITLEDvEPEMVEVLLRYIYS 93
Cdd:cd18220     8 YSNTVLSQ-LNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDH--SALSTMSGLSISVIK-NPNVFEQLLSFCYT 83

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1952522263  94 SEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQ 127
Cdd:cd18220    84 GRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILE 117
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-129 8.08e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 54.66  E-value: 8.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMF 113
Cdd:cd18324    25 DCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYL 104

                          90
                  ....*....|....*.
gi 1952522263 114 QIPSIFTVCISYLQKR 129
Cdd:cd18324   105 HMYDIVKVCKKKLKEK 120
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-124 9.50e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 53.68  E-value: 9.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  10 EPRIYQQTLLQEgLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMflsdLEESKKREITLEDVEPEMVEVLLR 89
Cdd:cd18225     2 ELPNYSRQLLQQ-LHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSL----LDSTDTISIDASVVSPEEFALLLE 76

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1952522263  90 YIYSSEVQLNDNNVQDIFTAANMFQipsIFTVCIS 124
Cdd:cd18225    77 MVYTGKLPPGKHNFTKIISVADSLQ---MFDVAVS 108
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-138 1.20e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 52.87  E-value: 1.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLeeskkreITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMF 113
Cdd:cd18275     6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDI-------LKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFL 78

                          90       100
                  ....*....|....*....|....*
gi 1952522263 114 QIPSIFTVCISYLQKRLGLSNCLAI 138
Cdd:cd18275    79 QMPCAAQCAVDAVRAQLCLGNCYEV 103
PLN02153 PLN02153
epithiospecifier protein
 393-587 1.31e-08

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 56.92  E-value: 1.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 393 PSPRCLFGLGEAENAIYVIGGkEVNEGEKTLDTVMCYDRHTFKWG----ESDPLPYEVYGHSVVSHNEKVYVIGGKGiAK 468
Cdd:PLN02153   20 PGPRCSHGIAVVGDKLYSFGG-ELKPNEHIDKDLYVFDFNTHTWSiapaNGDVPRISCLGVRMVAVGTKLYIFGGRD-EK 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 469 KCLNKMCVYNPQRFEWKELAPMKT-----ARSLFGAIVHRDKIWVATGVTDSGLTG------SIEVYDITTNKWeemVEF 537
Cdd:PLN02153   98 REFSDFYSYDTVKNEWTFLTKLDEeggpeARTFHSMASDENHVYVFGGVSKGGLMKtperfrTIEAYNIADGKW---VQL 174

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1952522263 538 P------QERSSLSLVTLSKCLYAIGGFAMMQTEAG--DFvptEINDIWKYDDEKEEW 587
Cdd:PLN02153  175 PdpgenfEKRGGAGFAVVQGKIWVVYGFATSILPGGksDY---ESNAVQFFDPASGKW 229
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-126 1.48e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 53.32  E-value: 1.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  24 RDLLennkfVDCILKVKGKEFPCHRLVLAACSPYFRAMFlSDLEESKKREITLE-DVEPEMVEVLLRYIYSSEVQLNDNN 102
Cdd:cd18331    21 RDIL-----TDVVIVVSREQFRAHKTVLMACSGLFYSIF-TDQLKCNLSVINLDpEINPEGFNILLDFMYTSRLNLREGN 94

                          90       100
                  ....*....|....*....|....
gi 1952522263 103 VQDIFTAANMFQIPSIFTVCISYL 126
Cdd:cd18331    95 IMAVMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-129 1.85e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 53.12  E-value: 1.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMF 113
Cdd:cd18325    25 DCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDIVTAPAFSLLLEFMYEGKLEFSSLPVEDVLAAASYL 104

                          90
                  ....*....|....*.
gi 1952522263 114 QIPSIFTVCISYLQKR 129
Cdd:cd18325   105 HMYDIVKVCKGKLKDK 120
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 34-106 1.96e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 51.95  E-value: 1.96e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLE--DVEPEMVEVLLRYIYSSEVQLNDNNVQDI 106
Cdd:cd18283     4 DVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPtaGIDVPMFSALLRYLYTGEFGSEDSRSQNL 78
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-129 2.86e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 52.51  E-value: 2.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  23 LRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRaMFLSDLEESKKREITLED--VEPEMVEVLLRYIYSSEVQLND 100
Cdd:cd18956    14 LRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDRPAGGRDTVRLNGdiVTAPAFGRLLDFMYEGRLDLRS 92

                          90       100
                  ....*....|....*....|....*....
gi 1952522263 101 NNVQDIFTAANMFQIPSIFTVCISYLQKR 129
Cdd:cd18956    93 LPVEDVLAAASYLHMYDIVKVCKGRLREK 121
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-127 4.49e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 51.97  E-value: 4.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  23 LRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFR-AMFLSDLEESKKREITledvEPEMVEVLLRYIYSSEVQLNDN 101
Cdd:cd18222    16 LNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRdHMSLNEMSTVSISVIK----NPTVFEQLLSFCYTGRICLQLA 91

                          90       100
                  ....*....|....*....|....*.
gi 1952522263 102 NVQDIFTAANMFQIPSIFTVCISYLQ 127
Cdd:cd18222    92 DIISYLTAASFLQMQHIIDKCTQILE 117
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 98-227 4.56e-08

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 51.07  E-value: 4.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  98 LNDNNVQDIFTAANMFQIPSIFTVCISYLQKrlglsnclaifrlglmldcprlavgardfvcdHFNLISKDQDFLQLSPS 177
Cdd:cd14822     1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDR--------------------------------NAQEVLSSEGFLTLSKS 48

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1952522263 178 EIIAIVASDSLNV-EKEeaVFEAVMSWAAHEESHLKALPELFDCIRFLLMP 227
Cdd:cd14822    49 ALKELLSRDSFCApEVD--IFNAVRRWCEHNPDSKEDAKEILEAVRLPLMS 97
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-127 6.43e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 51.01  E-value: 6.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  23 LRDLLennkfVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNN 102
Cdd:cd18332    15 KRDIL-----TDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLDFMYTSRLPLTPRT 89

                          90       100
                  ....*....|....*....|....*
gi 1952522263 103 VQDIFTAANMFQIPSIFTVCISYLQ 127
Cdd:cd18332    90 VPAVLAAATYLQMEHVVETCRRFIQ 114
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 34-113 7.74e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 50.21  E-value: 7.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLED--VEPEMVEVLLRYIYSSEVQLND-NNVQDIFTAA 110
Cdd:cd18190     1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEEngISIEAMRAVIDFSVTGRLDLFSvENVHEVLELA 80


                  ...
gi 1952522263 111 NMF 113
Cdd:cd18190    81 SKF 83
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-98 1.13e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 50.66  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  32 FVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDL-------------EESKKREITLEDVEPEMVEVLLRYIYSSEVQL 98
Cdd:cd18195    18 FCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLplgaaavaaapgaTQSPERVLELPGVKAGVFSDVLNFIYSSRVAL 97
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-113 1.20e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 50.33  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMF 113
Cdd:cd18298    14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPPEDAIGLLDLANSY 93
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-118 1.69e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 49.82  E-value: 1.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMF 113
Cdd:cd18192    23 DCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECFDLILQFMYLGKIMTAPSDFEQLKVAMNYL 102


                  ....*
gi 1952522263 114 QIPSI 118
Cdd:cd18192   103 QLYYI 107
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 130-203 1.70e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 49.19  E-value: 1.70e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1952522263 130 LGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLsPSEIIAIVASDS-LNVEKEEAVFEAVMSW 203
Cdd:cd18451     1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTL-PFHLVRDWLSDAeITVDSEEVLFEAVLKW 74
PLN02193 PLN02193
nitrile-specifier protein
 393-587 2.35e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 53.42  E-value: 2.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 393 PSPRCLFGLGEAENAIYVIGGkEVNEGEKTLDTVMCYDRHTFKWGES----DPLPYEVYGHSVVSHNEKVYVIGGKGIAK 468
Cdd:PLN02193  163 PGLRCSHGIAQVGNKIYSFGG-EFTPNQPIDKHLYVFDLETRTWSISpatgDVPHLSCLGVRMVSIGSTLYVFGGRDASR 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 469 KcLNKMCVYNPQRFEWKELAPMK---TARSLFGAIVHRDKIWVATGVTDSGLTGSIEVYDITTNKWeemvefpqerssLS 545
Cdd:PLN02193  242 Q-YNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW------------FH 308

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1952522263 546 LVTLSKCLYAIGGfAMMQTEAGD------FVPTEINDIWKYDDEKEEW 587
Cdd:PLN02193  309 CSTPGDSFSIRGG-AGLEVVQGKvwvvygFNGCEVDDVHYYDPVQDKW 355
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-136 2.84e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 49.98  E-value: 2.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  26 LLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMfLSDLEESKKREITLEDVEPEMVEVLLRYIY---SSEVQLNDNN 102
Cdd:cd18351    18 FLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKAL-LSNKPSAENTCIEISYVKYHIFQLVMQYLYcggTESLLIKNNE 96

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1952522263 103 VQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCL 136
Cdd:cd18351    97 IMELLSAAKFFQLEALQRHCEIICAKSINTENCV 130
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-128 2.95e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 49.44  E-value: 2.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  14 YQQTLLQEgLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLsdLEESKKREITLEDvEPEMVEVLLRYIYS 93
Cdd:cd18214     8 YGDSMLQK-MNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFL--LNDSREVQISILQ-NSEVGRQLLLSCYT 83

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1952522263  94 SEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQK 128
Cdd:cd18214    84 GVLEFPEMELVNYLTAASFLQMSHIVERCTQALWK 118
BTB1_POZ_LZTR1 cd18308
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 14-127 3.03e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349617 [Multi-domain]  Cd Length: 156  Bit Score: 50.45  E-value: 3.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  14 YQQTLLQEGLRDLLENNKF--VDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKR------------------- 72
Cdd:cd18308     5 YPKCTLHDDFGRLLESRQFcdVEFIVGEEEERIPAHIAFVAARSKWLRNKILQARERQKQKaeqevedegseadsssask 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1952522263  73 ------EITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQ-----------DIFTAANMFQIPSIFTVCISYLQ 127
Cdd:cd18308    85 ndspmlEVRLPEADPEAFELILSFIYTDKIDPTRKGQDpgsnevvllmmDVYRLALQFQMSRLEQLCVQYLE 156
PHA02713 PHA02713
hypothetical protein; Provisional
 426-583 5.15e-07

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 52.70  E-value: 5.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 426 VMCYDRHTFKWGESDPLPYEVYGHSVVSHNEKVYVIGGKGIAKKCLNKMCVYNPQRFEWKELAPMKTARSLFGAIVHRDK 505
Cdd:PHA02713  274 ILVYNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNFNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDT 353

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1952522263 506 IWVATGVTDSGLTGSIEVYDITTNKWEEMVEFPQERSSLSLVTLSKCLYAIGGfammQTEAGDFVPTE-INDIWKYDDE 583
Cdd:PHA02713  354 IYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGG----RTEHIDYTSVHhMNSIDMEEDT 428
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-122 6.17e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 48.70  E-value: 6.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  42 KEFPCHRLVLAACSPYFRAMFLSD-LEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFT 120
Cdd:cd18211    39 EEFSAHKAVLAASSKYFKEVFLNEkISDGKNTNVMLNEIYTADFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSE 118


                  ..
gi 1952522263 121 VC 122
Cdd:cd18211   119 TC 120
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 447-491 8.69e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 45.68  E-value: 8.69e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1952522263 447 YGHSVVSHNEKVYVIGGkGIAKKCLNKMCVYNPQRFEWKELAPMK 491
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGG-FDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-96 1.15e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 47.56  E-value: 1.15e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1952522263  31 KFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKrEITLEDVEPEMVEVLLRYIYSSEV 96
Cdd:cd18209    17 QLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENESQS-VFQLDFCEPDAFENVLNYIYSSSL 81
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-129 1.34e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 47.34  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  15 QQTLLQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFlSDLEESKKREITLEDVEPEMVEVLLRYIYSS 94
Cdd:cd18204     1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLF-KKLEVDSSSVIEIDFLRSDIFEEVLNYMYTA 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1952522263  95 EVQLNDNNVQDIFTAANMFQIPSIFTVCIsylQKR 129
Cdd:cd18204    80 KISVKKEDVNLMMSSGQILGIRFLDKLCS---QKR 111
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-115 1.50e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 47.30  E-value: 1.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  23 LRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAmFLSDLEESKKREItlEDVEPEMVEVLLRYIYSSEVQLND-N 101
Cdd:cd18221     9 LNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYK-FFQDFTQEPLVEI--EGVSNMAFRHLIEFTYTAKLMVQGeE 85

                          90
                  ....*....|....
gi 1952522263 102 NVQDIFTAANMFQI 115
Cdd:cd18221    86 EANDVWKAAEYLQM 99
Kelch smart00612
Kelch domain;
457-504 1.62e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 45.24  E-value: 1.62e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1952522263  457 KVYVIGGkGIAKKCLNKMCVYNPQRFEWKELAPMKTARSLFGAIVHRD 504
Cdd:smart00612   1 KIYVVGG-FDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 130-223 1.84e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 46.73  E-value: 1.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 130 LGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFL-QLSPSEIIAIVASDSLNVEKEEAVFEAVMSW---AA 205
Cdd:cd18482     1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQQLLAKEEELcELSLAQLKEVLMLDSLDVDSERKVCSVAVQWieaNL 80

                          90
                  ....*....|....*...
gi 1952522263 206 HEEShlKALPELFDCIRF 223
Cdd:cd18482    81 KERA--ASAAEVLKCVRW 96
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-131 1.84e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 47.27  E-value: 1.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  11 PRIYQQTLLQegLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDleeskkREITLED--VEPEMVEVLL 88
Cdd:cd18334     2 PNHAKQLLLQ--LNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHD------NLINLDTdmVNPTVFRQIL 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1952522263  89 RYIYSSEV----QLNDNNVQDIFTAANMFQIPSIFTVCISYLqKRLG 131
Cdd:cd18334    74 DFIYTGKLltsdQPGEQNFNALLTAASYLQLHDLAALCRKKL-KRNG 119
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-115 1.96e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 47.10  E-value: 1.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  14 YQQTLLQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESkkrEITLEDVEPEMVEVLLRYIYS 93
Cdd:cd18226     4 YNKNLLKYLNDDRQKQSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNPNTD---AVTLDHVSYSVFQHLLEFLYT 80

                          90       100
                  ....*....|....*....|..
gi 1952522263  94 SEVQLNDNNVQDIFTAANMFQI 115
Cdd:cd18226    81 SEFFVYENEIPLVLEAAKFLDI 102
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-130 2.40e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 46.87  E-value: 2.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263   9 EEPRIYQqtLLQEgLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIT--LEDVEPEMVEV 86
Cdd:cd18201     1 ENSYCYQ--LLQE-LNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQTTVthLDVVAVQGFSV 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1952522263  87 LLRYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKRL 130
Cdd:cd18201    78 ILDFMYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDAL 121
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-118 2.53e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 46.71  E-value: 2.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFlSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMF 113
Cdd:cd18212    25 DITLIVENVQFRAHKALLAASSEYFSMMF-ADEGEVGQSIYMLEGMVAETFGALLEFIYTGCLQVGEKSLEQILATAQFL 103


                  ....*
gi 1952522263 114 QIPSI 118
Cdd:cd18212   104 KVNDL 108
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-127 2.64e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 46.86  E-value: 2.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  14 YQQTLLQEgLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLsdLEESkkREITLEDV-EPEMVEVLLRYIY 92
Cdd:cd18227     8 FSSTILQK-LNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVL--LKNS--RRIVLPDVmNPRVFENILLSCY 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1952522263  93 SSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQ 127
Cdd:cd18227    83 TGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELLE 117
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-122 2.88e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 46.60  E-value: 2.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  21 EGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFL---SDLEESKKreitledVEPEMVEVLLRYIYSSEVQ 97
Cdd:cd18208    14 ETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLlgySDIEIPSV-------VSVQSVQKLIDFMYSGVLR 86

                          90       100
                  ....*....|....*....|....*
gi 1952522263  98 LNDNNVQDIFTAANMFQIPSIFTVC 122
Cdd:cd18208    87 VSQSEALQILTAASILQIKTVIDEC 111
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-98 3.01e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 46.39  E-value: 3.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  14 YQQTLLQEGLRDLLENnKFVDCILKVKGKEFPCHRLVLAACSPYFR-AMFLSDleeskKREITLEDV-EPEMVEVLLRYI 91
Cdd:cd18200     1 YSSALLETLNKHRLEG-KFCDLSVHVQGRVFRAHKAVLAASSPYFHdKLLLND-----TNCLVLPSViEAAAFENLLQLI 74


                  ....*..
gi 1952522263  92 YSSEVQL 98
Cdd:cd18200    75 YSGRLTL 81
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-122 3.22e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 46.38  E-value: 3.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  16 QTLLQEgLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSD-LEESKKREITLEDVEPEMVEVLLRYIYSS 94
Cdd:cd18202     4 QTVLDQ-LNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKgAVSSHEAVVDLSGFCKSSFLPLLEFAYTS 82

                          90       100
                  ....*....|....*....|....*...
gi 1952522263  95 EVQLNDNNVQDIFTAANMFQIPSIFTVC 122
Cdd:cd18202    83 ELTFDFCSMAEVAMLARHLFMNEVLEIC 110
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-118 3.83e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 46.57  E-value: 3.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  32 FVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSdleeSKKREITLE-DVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAA 110
Cdd:cd18290    27 YCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELPaAVQPQSFQQILSFCYTGRLSMNVGDQFLLMYTA 102


                  ....*...
gi 1952522263 111 NMFQIPSI 118
Cdd:cd18290   103 GFLQIQEI 110
mutarot_permut TIGR03548
cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...
 434-587 5.49e-06

cyclically-permuted mutarotase family protein; Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.


Pssm-ID: 274642 [Multi-domain]  Cd Length: 331  Bit Score: 48.63  E-value: 5.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 434 FKWGESDPLPYEV-YGHSvVSHNEKVYVIGGKG----------IAKKCLNKMCVYNPqrfewkeLAPMKTARSLFGAIVH 502
Cdd:TIGR03548  52 LKWVKAGQLPYEIaYGAS-VSTPYGIYYVGGSPssesfsdvllLSLDDTKEALIIET-------LPSLPVAFDNGSATYK 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 503 RDKIWVATGVTDSGLTGSIEVYDI--TTNKWEEMVEFPQE-RSSLSLVTLSKCLYAIGGFammqTEAGDfvPTEINDIWK 579
Cdd:TIGR03548 124 DGKIYVGGGNANGKPSNKFYCLDLsnDTSGWEELPEFPGEaRVQPVCQALHGKLYVFGGF----QLGGD--AIIYTDGYA 197


                  ....*...
gi 1952522263 580 YDDEKEEW 587
Cdd:TIGR03548 198 YSPKTNTW 205
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 134-226 6.69e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 45.14  E-value: 6.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 134 NCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSW------AAHE 207
Cdd:cd18461     5 NILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLYhytpeqVEKD 84

                          90
                  ....*....|....*....
gi 1952522263 208 ESHLKALPELFDCIRFLLM 226
Cdd:cd18461    85 QVSLQEPPKLLEAVRFPLM 103
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-122 7.69e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 45.64  E-value: 7.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  26 LLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLsdLEESKKREITLEDvEPEMVEVLLRYIYSSEVQLNDNNVQD 105
Cdd:cd18203    19 LRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFL--LNPSSELQVSLMH-SSRVVADLLLSCYTGALEFSVRDIVN 95

                          90
                  ....*....|....*..
gi 1952522263 106 IFTAANMFQIPSIFTVC 122
Cdd:cd18203    96 YLTAASYLQMEHVVEKC 112
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 130-223 8.49e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 44.87  E-value: 8.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 130 LGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHEES 209
Cdd:cd18470     1 INVENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFDQK 80

                          90
                  ....*....|....
gi 1952522263 210 HLKALPELFDCIRF 223
Cdd:cd18470    81 RVKYAADLLSNIRF 94
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-116 8.54e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 45.16  E-value: 8.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  32 FVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLND-NNVQDIFTAA 110
Cdd:cd18223    18 LCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEIWISSHVLELPDLKAEVFAEILNFIYSSKVVVKRqETVTDLVAAG 97


                  ....*.
gi 1952522263 111 NMFQIP 116
Cdd:cd18223    98 KKLGIT 103
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 18-115 9.92e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 44.88  E-value: 9.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  18 LLQEgLRDLLENNKFVDCILK-VKGKEFPCHRLVLAACSPYFRAmfLSDLEESKKREITL-EDVEPEMVEVLLRYIYSSE 95
Cdd:cd18311     1 FLQR-LQNLFNKTEYCDLTLQfRDNEQLKVHRLVLSACTDYFNV--LEQTCEIVDDTLIMpNELQADAVVPVINFMYTGQ 77

                          90       100
                  ....*....|....*....|
gi 1952522263  96 VQLNDNNVQDIFTAANMFQI 115
Cdd:cd18311    78 LEFEEKSYGKLLRTAKELNM 97
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-128 1.09e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 44.89  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLSDleeskkreiTLEDVEPEMV-----EVLLRYIYSSEV----QLNDNNVQ 104
Cdd:cd18333    23 DVIIVVQNALFRAHKNILAASSVYLKSLVVHD---------NLINLDHEMVspgifRLILDYIYTGRLsegdPGSEQNLG 93

                          90       100
                  ....*....|....*....|....
gi 1952522263 105 DIFTAANMFQIPSIFTVCISYLQK 128
Cdd:cd18333    94 AVLAAASYLQIPDLVALCKKKLKR 117
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 493-538 1.12e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.60  E-value: 1.12e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1952522263 493 ARSLFGAIVHRDKIWVATGVTDSGLTGSIEVYDITTNKWEEMVEFP 538
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-129 1.38e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 44.47  E-value: 1.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  14 YQQTLLqEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLsdLEESkkrEITLEDVEP-EMVEVLLRYIY 92
Cdd:cd18229     1 FSKSLL-ETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLL--LGHS---EIEVPPVVPaQTVRQLVEFMY 74

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1952522263  93 SSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYLQKR 129
Cdd:cd18229    75 SGSLVVAQSEALQILTAASILQIKTVIDECTQIISQS 111
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-126 1.81e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 44.16  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLSdleESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMF 113
Cdd:cd18218    20 DTLITVGSQEFPAHSLVLAGASQQLGRQLTN---PNPGQWCLGEGISPSTFKQLLDFVYGESVEVQPGELRPLLEAARAL 96

                          90
                  ....*....|...
gi 1952522263 114 QIPSIFTVCISYL 126
Cdd:cd18218    97 EVESLEEACWRAL 109
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-128 1.85e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 44.45  E-value: 1.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLSDleeskkREITLED--VEPEMVEVLLRYIYSSEVQLND---NNVQDIFT 108
Cdd:cd18216    22 DVIIVVENSLFRAHKNVLAASSGYFKSLVLHD------NLIHLDQdmVSPTVFQQILDFIYTGKLLDSLfeePNLSEVLA 95

                          90       100
                  ....*....|....*....|
gi 1952522263 109 AANMFQIPSIFTVCISYLQK 128
Cdd:cd18216    96 AANYLQLPDLAALCRSKLKR 115
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-126 2.02e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 43.87  E-value: 2.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFlsdleESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMF 113
Cdd:cd18205    20 DVVIMVDSQEFHAHRTVLACTSKMFEILF-----HRNSQHYTLDFLSPKTFQQILEYAYTATLQAKVEDLDDLLYAAEIL 94

                          90
                  ....*....|...
gi 1952522263 114 QIPSIFTVCISYL 126
Cdd:cd18205    95 EIEYLEEQCLKIL 107
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 130-206 2.66e-05

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 42.72  E-value: 2.66e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1952522263 130 LGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAH 206
Cdd:cd18503     1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-124 3.23e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 43.67  E-value: 3.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLSDlEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAANMF 113
Cdd:cd18224    28 DVTIVVGNRSFAAHKAVLACAAGYFQKLFLST-ELDVARTYVVDFITPANFEKVLSFIYTSELFTDLINVGVIYEVAEKL 106

                          90
                  ....*....|.
gi 1952522263 114 QIPSIFTVCIS 124
Cdd:cd18224   107 GMEDLLKACHS 117
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 41-98 3.26e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 44.22  E-value: 3.26e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1952522263  41 GKEFPCHRLVLAACSPYFRAMFLSDLEES--KKREITLEDVEP------EMVEVLLRYIYSSEVQL 98
Cdd:cd18310    28 GRPVPVHRCILAARSPFFRDIFASAKAEGanTKPKLELRELIPggivgyDAFMLVLSYLYSGRLRL 93
BTB_POZ_ARMC5 cd18191
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-92 3.64e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349500 [Multi-domain]  Cd Length: 100  Bit Score: 42.88  E-value: 3.64e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1952522263  41 GKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIY 92
Cdd:cd18191    11 GTQLPASRAALTGASEVFRAMLEGGFAEAQQDLVPLRQVPSGAFLPVLHYLH 62
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 23-118 4.51e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 42.58  E-value: 4.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  23 LRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRamflSDLEESKKREITLE-DVEPEMVEVLLRYIYSSEVQLNDN 101
Cdd:cd18262     9 AQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFR----ERLLGSNGPLPPLSlEVTPVGWEAVLTFAYTGVLGRNPA 84

                          90
                  ....*....|....*..
gi 1952522263 102 NVQDIFTAANMFQIPSI 118
Cdd:cd18262    85 TVGDILVAAEALGAPRV 101
BTB_POZ_BT cd18313
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-130 5.40e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349622 [Multi-domain]  Cd Length: 102  Bit Score: 42.46  E-value: 5.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  41 GKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNN--VQDIFTAANMFQIPSI 118
Cdd:cd18313    11 NSHIPAHSNVLASASPVIAGMLKQPRRKSSKKVIKILGVPCDAVRVFIRFLYSSCYEEEEMEkfGIHLLVLSHVYVVPQL 90

                          90
                  ....*....|..
gi 1952522263 119 FTVCISYLQKRL 130
Cdd:cd18313    91 KRVCEKGLEQGL 102
BTB_POZ_BTBD16 cd18291
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-134 7.68e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 16 (BTBD16); BTBD16 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349600  Cd Length: 114  Bit Score: 42.43  E-value: 7.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLaacspyFRAMFLSDL--EESKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAAN 111
Cdd:cd18291    14 DVVLECLGSFWELHSPYL------CKSETLAELlkPVTISLNINDPLVTKEAFAVALGNLYNSEVEVNVEDAVGVLAAAA 87

                          90       100
                  ....*....|....*....|...
gi 1952522263 112 MFQIPSIFTVCISYLQKRLGLSN 134
Cdd:cd18291    88 LLRFPTLFQKCVKVMISSISSST 110
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 23-127 1.12e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 41.76  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  23 LRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYS------SEV 96
Cdd:cd18360     1 LGLFFNSPLLADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTdsccpaSIL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1952522263  97 QlndnnVQDIFTAANMFQIPSIFTVC----ISYLQ 127
Cdd:cd18360    81 Q-----AMALLICAEMYQVSRLQHICelyiITQLQ 110
BTB2_POZ_BTBD7 cd18284
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 43-99 1.13e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349593  Cd Length: 146  Bit Score: 42.71  E-value: 1.13e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1952522263  43 EFPCHRLVLAACSPYFRAMFL------SDLEESKKREITL-EDVEPE-MVEVLLRYIYSSEVQLN 99
Cdd:cd18284    29 ELRCHKAILSARSPFFRNLLQrrirtgEDRTLSTPTRIVLdESIIPRrYARVLLHAMYTDSVDLS 93
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-136 1.35e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 42.14  E-value: 1.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  27 LENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFL--SDLEESKKREITLEDVEPEMVEVLLRYIY-----SSEVQLN 99
Cdd:cd18350    19 LNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTnkSEQESQGSKTIEISDIKYHIFQMLMQYLYyggteSMEIPIA 98

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1952522263 100 DnnVQDIFTAANMFQIPSIFTVCISYLQKRLGLSNCL 136
Cdd:cd18350    99 D--VLELLSAASLFQLDALQRHCEILCSQTINLENAV 133
Kelch smart00612
Kelch domain;
408-456 1.50e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.46  E-value: 1.50e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1952522263  408 IYVIGGkevNEGEKTLDTVMCYDRHTFKWGESDPLPYEVYGHSVVSHNE 456
Cdd:smart00612   2 IYVVGG---FDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB1_POZ_BTBD8 cd18285
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 26-96 1.82e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349594 [Multi-domain]  Cd Length: 104  Bit Score: 41.18  E-value: 1.82e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1952522263  26 LLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKRE-ITLEDVEPEMVEVLLRYIYSSEV 96
Cdd:cd18285     9 LLREELHTDVTFYVGSTLFKAHKAILLARVPEFFSHIIGKLSSLEDQEpINIENLEASEFKTFLRQVYTSDK 80
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-118 1.95e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 41.55  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  32 FVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDleeSKKREITLEDVEPEMVEVLLRYIYSSEVQLNDNNVQDIFTAAN 111
Cdd:cd18289    29 YCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGN---SKSAFELPATVPPACFQQILSFCYTGKLTMAASEQLVVMYTAG 105


                  ....*..
gi 1952522263 112 MFQIPSI 118
Cdd:cd18289   106 FLQIQHI 112
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 130-226 1.98e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 40.66  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 130 LGLSNCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHEES 209
Cdd:cd18465     1 MSVETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPS 80

                          90
                  ....*....|....*..
gi 1952522263 210 HLKALPELFDCIRFLLM 226
Cdd:cd18465    81 RRASASHVLCHIRFPLM 97
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-126 2.61e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 40.98  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  11 PRIyqQTLLQEGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESkkreITLEDV-EPEMVEVLLR 89
Cdd:cd18210     2 PEI--TSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHDQVLLKNMSS----ISLPGVmDPGAFESVLA 75

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1952522263  90 YIYSSEVQLNDNNVQDIFTAANMFQIPSIFTVCISYL 126
Cdd:cd18210    76 SAYTGKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
BACK_KLHL15 cd18454
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...
 132-226 3.76e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.


Pssm-ID: 350529  Cd Length: 108  Bit Score: 40.26  E-value: 3.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 132 LSNCLAIFRLglmLDCPRLAV-GARD----FVCDHFNLISKDQDFLQ-LSPSEIIAIVASDSLNVEKEEAVFEAVMSWAA 205
Cdd:cd18454     3 LDNCAEIMRL---LDDFSVNIeGVREkldsFLLENFVPLMSRPDFLSyLSFEKLMSYLDNDHLSRFPEIELYEAVQAWLR 79

                          90       100
                  ....*....|....*....|.
gi 1952522263 206 HEESHLKALPELFDCIRFLLM 226
Cdd:cd18454    80 HDRRRWRHTDTIIQNIRFCLM 100
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-114 3.86e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 39.86  E-value: 3.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  42 KEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQ---------LNDNN-VQDIFTAAN 111
Cdd:cd18319    11 RCYNVSKRKLIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHesqgdstdtLEENElLEDLVEAAS 90


                  ...
gi 1952522263 112 MFQ 114
Cdd:cd18319    91 FLQ 93
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 395-436 5.06e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.98  E-value: 5.06e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1952522263 395 PRCLFGLGEAENAIYVIGGKevnEGEKTLDTVMCYDRHTFKW 436
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGF---DGNQSLNSVEVYDPETNTW 39
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-96 7.08e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 39.43  E-value: 7.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  14 YQQTLLQeGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFlsdleESKKREITLEDVEPEMVEVLLRYIYS 93
Cdd:cd18219     4 YSGSLLK-SLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLF-----SVAGQVVELNFIRADIFAEILNYIYS 77


                  ...
gi 1952522263  94 SEV 96
Cdd:cd18219    78 SKI 80
BACK_KLHL36 cd18475
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...
 134-228 7.29e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350550  Cd Length: 100  Bit Score: 39.05  E-value: 7.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 134 NCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQ-LSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHEESHLK 212
Cdd:cd18475     5 NYLYLQELASIYSLERLDSFIDSFILQNFGTLSFTPDFLQnVSMQKLCQYLSSNQVQHECEHDLLQAALQWLTQSPEREN 84

                          90
                  ....*....|....*.
gi 1952522263 213 ALPELFDCIRFLLMPK 228
Cdd:cd18475    85 EAYQVLSNIHFPLIPK 100
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-93 7.72e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 39.88  E-value: 7.72e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITleDVEPEMVEVLLRYIYS 93
Cdd:cd18213    23 DCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQSSECIKIQPT--DIQPDIFSYLLHIMYT 80
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 156-223 7.86e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 38.94  E-value: 7.86e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952522263 156 DFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHEESHLKALPELFDCIRF 223
Cdd:cd18449    27 DFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHEDDRMQFAAKLMENIRF 94
Kelch_3 pfam13415
Galactose oxidase, central domain;
455-502 9.68e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 37.27  E-value: 9.68e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1952522263 455 NEKVYVIGGKG-IAKKCLNKMCVYNPQRFEWKELAPMKTARSLFGAIVH 502
Cdd:pfam13415   1 GDKLYIFGGLGfDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
BACK_KLHL14 cd18453
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...
 169-236 1.05e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.


Pssm-ID: 350528  Cd Length: 102  Bit Score: 38.85  E-value: 1.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1952522263 169 QDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHE-ESHLKALPELFDCIRFLLMPKEYLKEHVE 236
Cdd:cd18453    31 EDVLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDrETRMQYAPDLMKRLRFALIPAPELVERVQ 99
PLN02193 PLN02193
nitrile-specifier protein
 357-545 1.26e-03

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 41.48  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 357 VAGGLYYNEGDKENPLHSYFLQFDHLDCDWLGMPPL---PSPRCLFGLGEAENAIYVIGGKEVNEGEKTLDTVMCYDRht 433
Cdd:PLN02193  227 IGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVeegPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDK-- 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 434 fKWGE-SDPL-PYEVYGHS---VVshNEKVYVIGGkgiAKKC-LNKMCVYNPQRFEWKELAPM---KTARSLFGAIVHRD 504
Cdd:PLN02193  305 -KWFHcSTPGdSFSIRGGAgleVV--QGKVWVVYG---FNGCeVDDVHYYDPVQDKWTQVETFgvrPSERSVFASAAVGK 378

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1952522263 505 KIWVATG---------VTDSGLTGSIEVYDITTNKWEEMVEFPQERSSLS 545
Cdd:PLN02193  379 HIVIFGGeiamdplahVGPGQLTDGTFALDTETLQWERLDKFGEEEETPS 428
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 541-587 2.03e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.44  E-value: 2.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1952522263 541 RSSLSLVTLSKCLYAIGGFAMmqteagdfvPTEINDIWKYDDEKEEW 587
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDG---------NQSLNSVEVYDPETNTW 39
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 154-231 2.23e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 38.18  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 154 ARDFVCDHF-NLISKDQD---FLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSWAAHEESHLKALPELFDCIRFLLMPKE 229
Cdd:cd18473    25 AEKYIISNLwRLLASDADdagLLELNLESLQAVLEADDIPRVKESRLLTLVLEWLNQDESRLAYANALLSRIRYGLVPVE 104


                  ..
gi 1952522263 230 YL 231
Cdd:cd18473   105 EL 106
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-98 2.95e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 38.01  E-value: 2.95e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952522263  21 EGLRDLLENNKFVDCILKVKGKEFPCHRLVLAACSPYFRAMFLSDLEESKKREITLEDVEPEMVEVLLRYIYSSEVQL 98
Cdd:cd18353     9 ESLKKEFDSPETSDLKFRVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKEVIEIDQFSYPVYRAFLEYLYTDSVDL 86
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 34-110 3.00e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 37.70  E-value: 3.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1952522263  34 DCILKVKGKEFPCHRLVLAACSPYFRAMfLSDLEESKKREITLEDVE--PEMVEVLLRYIYSSEVQLNDNNVQDIFTAA 110
Cdd:cd18312    11 DITVRVGNTTFHLHKFPLCSKSGYFKRL-ASSSSESDPSEIELNDFPggAEAFELVAKFCYGMPINLTATNVVGLRCAA 88
PRK14131 PRK14131
N-acetylneuraminate epimerase;
498-587 3.29e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 40.00  E-value: 3.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263 498 GAIVHrDKIWVatgvtdsGLtGSIEV--YDITTNK----WEEMVEFP-QERSSLSLVTLSKCLYAIGGFammQTEAGDFV 570
Cdd:PRK14131   34 GAIDN-NTVYV-------GL-GSAGTswYKLDLNApskgWTKIAAFPgGPREQAVAAFIDGKLYVFGGI---GKTNSEGS 101

                          90
                  ....*....|....*..
gi 1952522263 571 PTEINDIWKYDDEKEEW 587
Cdd:PRK14131  102 PQVFDDVYKYDPKTNSW 118
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 150-203 3.63e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 36.40  E-value: 3.63e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1952522263 150 LAVGARDFVCDHFNLISKDQDFLQLSPSEIIAIVASDSLNVEKEEAVFEAVMSW 203
Cdd:cd18493    20 LAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKW 73
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 447-490 6.05e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 35.00  E-value: 6.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1952522263 447 YGHSVVSHNEKVYVIGGKGIAKKC-LNKMCVYNPQRFEWKELAPM 490
Cdd:pfam07646   3 YPHASSVPGGKLYVVGGSDGLGDLsSSDVLVYDPETNVWTEVPRL 47
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 134-204 7.34e-03

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 36.44  E-value: 7.34e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1952522263 134 NCLAIFRLGLMLDCPRLAVGARDFVCDHFNLISKDQDFLQLS--PSEIIAiVASDSLNVEKEEAVFEAVMSWA 204
Cdd:cd18502     5 NCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPrlQIEVIL-ESNQELESINERKLCQLVLEWV 76
BTB_POZ_M2BP cd18304
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-122 8.09e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Mac-2-binding protein (MAC2BP/M2BP); M2BP is also called galectin-3-binding protein, basement membrane autoantigen p105, lectin galactoside-binding soluble 3-binding protein (LGALS3BP), or tumor-associated antigen 90K. It promotes integrin-mediated cell adhesion and may stimulate host defense against viruses and tumor cells. It contains a scavenger receptor cysteine-rich domain, followed by BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349613 [Multi-domain]  Cd Length: 114  Bit Score: 36.69  E-value: 8.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952522263  19 LQEGLRDLLENNKFVD--CILKVKGKE-----FPCHRLVLAAcspYFRAMFLSDleeSKKREITLeDVEPE---MVEVLL 88
Cdd:cd18304     4 LSEDLGLLYDSQQGCDfnISVLTAGGEeeeltFCAHRVILML---SPEANFLHK---TGSSNITL-DVDEEclpHVPDFL 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1952522263  89 RYIYSSEVQLNDNNVQDIFTAANMFQIPSIFTVC 122
Cdd:cd18304    77 RYFYTRQIDITLTSVKCFHKLASIYGVRKLREYC 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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