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Conserved domains on  [gi|1907162830|ref|XP_036020957|]
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beta-alanine-activating enzyme isoform X12 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PQQ super family cl34291
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 218-369 1.22e-14

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG1520:

Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 75.62  E-value: 1.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 218 DENLEKPPLFQQGSPVVgamamALRERWRSDTGKCVDASPLLVRAAVQDkpsTTVYIGSHSHTVKAVDLSSGETRWEQLL 297
Cdd:COG1520    14 EDDEPPPAPLPEFEPSV-----KVKQLWSASVGDGVGKGYSRLAPAVAG---DRVYAADADGRVAALDAATGKELWRVDL 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907162830 298 GDRIesSACVSKCGNFIVVGCYNGLVYVLKSNSGEKYWTFTTEDAVKSSPAVDptTGLIYVGSHDQHAYALD 369
Cdd:COG1520    86 GEPL--SGGVGADGGLVVVGTEDGEVIALDADDGEELWRARLSSEVLAAPAVA--GGRVVVRTGDGRVYALD 153
PQQ_2 super family cl38403
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 280-500 3.77e-14

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


The actual alignment was detected with superfamily member pfam13360:

Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 72.05  E-value: 3.77e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 280 TVKAVDLSSGETRWEQLLGDRIESSACVSkcGNFIVVGCYNGLVYVLKSNSGEKYWTFTTEDAVKSSPAVDptTGLIYVG 359
Cdd:pfam13360   4 VVTALDAATGAELWRVDLETGLGGGVAVD--GGRLFVATGGGQLVALDAATGKLLWRQTLSGEVLGAPLVA--GGRVFVV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 360 SHDQHAYALDIYEKKCVWKL---NCEGALFSSPCVSLSPHHLYCATLGGLLLALNPASGSTVWKRSCGKP---------- 426
Cdd:pfam13360  80 AGDGSLIALDAADGRRLWSYqrsGEPLALRSSGSPAVVGDTVVAGFSSGKLVALDPATGKVRWEAPLAAPrgtnelerlv 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907162830 427 -LFSSPRCYQQYICIGCVDGSLLCF-THSGEQVWRFAAGGPifSSPCVsaAEQEIFFGSHDCFIYCCS-KEGHLRWK 500
Cdd:pfam13360 160 dITGTPVVAGGRVFASAYQGRLVAFdAATGRRLWTREISGP--NGPIL--DGDLLYVVSDDGELYALDrATGAVVWK 232
PQQ super family cl34291
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 453-568 5.59e-07

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG1520:

Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 52.12  E-value: 5.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 453 SGEQVWRFAAGGPIfSSPcVSAAEQEIFFGSHDCFIYCCSKE-GHLRWKFETTARVYATPfafsnhpRSDDALLAAASTD 531
Cdd:COG1520    76 TGKELWRVDLGEPL-SGG-VGADGGLVVVGTEDGEVIALDADdGEELWRARLSSEVLAAP-------AVAGGRVVVRTGD 146

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1907162830 532 GKLWVLESRSGELRSVYELPGEVF-----SSPVVWESMLVIG 568
Cdd:COG1520   147 GRVYALDAATGERLWSYQRPVPALtlrgtSSPVIVGGAVLVG 188
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 49-98 2.81e-05

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


:

Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 42.17  E-value: 2.81e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907162830  49 LWKSILCLPEDPedtlkVPANSVFLDSGGDSLKSMRLLSEIERLTGTAIP 98
Cdd:pfam00550   6 LLAEVLGVPAEE-----IDPDTDLFDLGLDSLLAVELIARLEEEFGVEIP 50
 
Name Accession Description Interval E-value
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 218-369 1.22e-14

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 75.62  E-value: 1.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 218 DENLEKPPLFQQGSPVVgamamALRERWRSDTGKCVDASPLLVRAAVQDkpsTTVYIGSHSHTVKAVDLSSGETRWEQLL 297
Cdd:COG1520    14 EDDEPPPAPLPEFEPSV-----KVKQLWSASVGDGVGKGYSRLAPAVAG---DRVYAADADGRVAALDAATGKELWRVDL 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907162830 298 GDRIesSACVSKCGNFIVVGCYNGLVYVLKSNSGEKYWTFTTEDAVKSSPAVDptTGLIYVGSHDQHAYALD 369
Cdd:COG1520    86 GEPL--SGGVGADGGLVVVGTEDGEVIALDADDGEELWRARLSSEVLAAPAVA--GGRVVVRTGDGRVYALD 153
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 280-500 3.77e-14

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 72.05  E-value: 3.77e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 280 TVKAVDLSSGETRWEQLLGDRIESSACVSkcGNFIVVGCYNGLVYVLKSNSGEKYWTFTTEDAVKSSPAVDptTGLIYVG 359
Cdd:pfam13360   4 VVTALDAATGAELWRVDLETGLGGGVAVD--GGRLFVATGGGQLVALDAATGKLLWRQTLSGEVLGAPLVA--GGRVFVV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 360 SHDQHAYALDIYEKKCVWKL---NCEGALFSSPCVSLSPHHLYCATLGGLLLALNPASGSTVWKRSCGKP---------- 426
Cdd:pfam13360  80 AGDGSLIALDAADGRRLWSYqrsGEPLALRSSGSPAVVGDTVVAGFSSGKLVALDPATGKVRWEAPLAAPrgtnelerlv 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907162830 427 -LFSSPRCYQQYICIGCVDGSLLCF-THSGEQVWRFAAGGPifSSPCVsaAEQEIFFGSHDCFIYCCS-KEGHLRWK 500
Cdd:pfam13360 160 dITGTPVVAGGRVFASAYQGRLVAFdAATGRRLWTREISGP--NGPIL--DGDLLYVVSDDGELYALDrATGAVVWK 232
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 218-369 2.37e-12

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 68.81  E-value: 2.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 218 DENLEKPPLFQQGSPVVgamamALRERWRSDTGKCVDASPLLVRAAVQDkpsTTVYIGSHSHTVKAVDLSSGETRWEQLL 297
Cdd:TIGR03300  22 EDDEPQPAELPEFQPTV-----KVDQVWSASVGDGVGHYYLRLQPAVAG---GKVYAADADGTVAALDAETGKRLWRVDL 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907162830 298 GDRIesSACVSKCGNFIVVGCYNGLVYVLKSNSGEKYWTFTTEDAVKSSPAVDptTGLIYVGSHDQHAYALD 369
Cdd:TIGR03300  94 DERL--SGGVGADGGLVFVGTEKGEVIALDAEDGKELWRAKLSSEVLSPPLVA--NGLVVVRTNDGRLTALD 161
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 332-578 8.59e-11

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 63.89  E-value: 8.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 332 EKYWTFTTEDAVKSSPAVDptTGLIYVGSHDQHAYALDIYEKKCVWKLNCEGALFSSPCVSLSPHHLYCATLGGLLLALN 411
Cdd:cd10276    19 SKSVGNGGMAGIDLTPVVA--GDMVYAADANGQVSAFNATTGKIIWETSLSGKGFLGGTPAVGNGKIFVGTESGYLYALD 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 412 PASGSTVWKRSCGKPLFSSPRCYQQ-YICIGCVDGSLLCF-THSGEQVWRFAAGGPIFSSPCVSA---AEQEIFFGSHDC 486
Cdd:cd10276    97 AKDGSELWRTEVSDSQLLSPPTYADgKIYVGTGDGRLYYCnAETGKVVWNRTSTAPELSLRGGAApvgAYDVVFVGDGNG 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 487 FIYCCSKE-GHLRWKFETTARVYATP----FAFSNHPRSDDALLAAASTDGKLWVLESRSGELRSVYELpGEVFSSPVVW 561
Cdd:cd10276   177 TVVALNTGtGVDIWEFSVSEPRGRTElprmIDSSVTYVVVGGYLYSTSYQGYLVALDFESGQFLWSRKA-SGGTSTSTDA 255

                         250
                  ....*....|....*..
gi 1907162830 562 ESMLVIGCRNNYIYCLD 578
Cdd:cd10276   256 NGRVYVGDGEGSLYCLD 272
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 453-568 5.59e-07

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 52.12  E-value: 5.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 453 SGEQVWRFAAGGPIfSSPcVSAAEQEIFFGSHDCFIYCCSKE-GHLRWKFETTARVYATPfafsnhpRSDDALLAAASTD 531
Cdd:COG1520    76 TGKELWRVDLGEPL-SGG-VGADGGLVVVGTEDGEVIALDADdGEELWRARLSSEVLAAP-------AVAGGRVVVRTGD 146

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1907162830 532 GKLWVLESRSGELRSVYELPGEVF-----SSPVVWESMLVIG 568
Cdd:COG1520   147 GRVYALDAATGERLWSYQRPVPALtlrgtSSPVIVGGAVLVG 188
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 261-380 1.46e-06

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 50.70  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 261 RAAVQDkpsTTVYIGSHSHTVKAVDLSSGETRWEQLLGDRIES---------SACVSKCGNFIVVGCYNGLVYVLKSNSG 331
Cdd:PRK11138   64 HPAVAY---NKVYAADRAGLVKALDADTGKEIWSVDLSEKDGWfsknksallSGGVTVAGGKVYIGSEKGQVYALNAEDG 140

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1907162830 332 EKYWTFTTEDAVKSSPAVDptTGLIYVGSHDQHAYALDIYEKKCVWKLN 380
Cdd:PRK11138  141 EVAWQTKVAGEALSRPVVS--DGLVLVHTSNGMLQALNESDGAVKWTVN 187
PQQ_3 pfam13570
PQQ-like domain;
331-368 8.63e-06

PQQ-like domain;


Pssm-ID: 463925 [Multi-domain]  Cd Length: 36  Bit Score: 42.57  E-value: 8.63e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907162830 331 GEKYWTFTTEDAVKSSPAVDptTGLIYVGSHDQHAYAL 368
Cdd:pfam13570   1 GEVLWRFETGGPIVSSPAVA--GGLVYVGTGDGTLYAL 36
WD40 COG2319
WD40 repeat [General function prediction only];
245-539 1.08e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 245 WRSDTGKCV---DASPLLVRAAVQDKPSTTVYIGSHSHTVKAVDLSSGETRWEqLLGDRIE-SSACVSKCGNFIVVGCYN 320
Cdd:COG2319   147 WDLATGKLLrtlTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTGAvRSVAFSPDGKLLASGSAD 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 321 GLVYVLKSNSGEKYWTFTTEDAVKSSPAVDPTTGLIYVGSHDQHAYALDIYEKKCVWKLncEGALFSSPCVSLSP--HHL 398
Cdd:COG2319   226 GTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL--TGHSGGVNSVAFSPdgKLL 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 399 ycatlgglllalnpASGS-----TVWKRSCGKPLfssprcyqqyicigcvdgsllcFTHSGEQVWRFAAggpifsspCVS 473
Cdd:COG2319   304 --------------ASGSddgtvRLWDLATGKLL----------------------RTLTGHTGAVRSV--------AFS 339

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907162830 474 AAEQEIFFGSHDcfiyccskeGHLR-WKFET----------TARVYAtpFAFSnhprSDDALLAAASTDG--KLWVLES 539
Cdd:COG2319   340 PDGKTLASGSDD---------GTVRlWDLATgellrtltghTGAVTS--VAFS----PDGRTLASGSADGtvRLWDLAT 403
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 49-98 2.81e-05

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 42.17  E-value: 2.81e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907162830  49 LWKSILCLPEDPedtlkVPANSVFLDSGGDSLKSMRLLSEIERLTGTAIP 98
Cdd:pfam00550   6 LLAEVLGVPAEE-----IDPDTDLFDLGLDSLLAVELIARLEEEFGVEIP 50
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 411-582 7.11e-05

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 45.31  E-value: 7.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 411 NPASGSTVWKRSCGKplfsSPRCYQQYICIGCVDGSLlcFT------------HSGEQVWRFAAGGPIfsSPCVSAAEQE 478
Cdd:TIGR03300  36 PTVKVDQVWSASVGD----GVGHYYLRLQPAVAGGKV--YAadadgtvaaldaETGKRLWRVDLDERL--SGGVGADGGL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 479 IFFGSHDCFIYCCSKE-GHLRWKFETTARVYATPFafsnhprSDDALLAAASTDGKLWVLESRSGELRSVYELPGEVF-- 555
Cdd:TIGR03300 108 VFVGTEKGEVIALDAEdGKELWRAKLSSEVLSPPL-------VANGLVVVRTNDGRLTALDAATGERLWTYSRVTPPLtl 180

                         170       180       190
                  ....*....|....*....|....*....|
gi 1907162830 556 ---SSPVVWESMLVIGCRNNYIYCLDLLCG 582
Cdd:TIGR03300 181 rgsASPVIADGGVLVGFAGGKLVALDLQTG 210
PQQ_DH_like cd00216
PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases ...
 249-359 8.87e-05

PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases with pyrroloquinoline quinone (PQQ) as a cofactor, such as ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller, and the family also includes distantly related proteins which are not enzymatically active and do not bind PQQ.


Pssm-ID: 199833 [Multi-domain]  Cd Length: 434  Bit Score: 45.29  E-value: 8.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 249 TGKCVDASPLLVRAAVQDkpsTTVYIGSHSHTVKAVDLSSGETRWEQLLGDRIESSAcVSKCGNFIVVGCYNGLVYVLKS 328
Cdd:cd00216   296 NGELVSARPLVPDSYDPD---RELFYVPANGRIMALDPVTGVVVWEKSELHPLLGGP-LSTAGNLVFVGTSDGYLKAYNA 371

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1907162830 329 NSGEKYWTFTTEDAVKSSPAVDPTTGLIYVG 359
Cdd:cd00216   372 DTGEKLWQQKVPSGFQAEPVTYEVDGEQYVL 402
PQQ smart00564
beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline ...
 307-338 1.27e-03

beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline quinone (PQQ) as cofactor, in Ire1p-like Ser/Thr kinases, and in prokaryotic dehydrogenases.


Pssm-ID: 128836 [Multi-domain]  Cd Length: 33  Bit Score: 36.36  E-value: 1.27e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907162830  307 VSKCGNFIVVGCYNGLVYVLKSNSGEKYWTFT 338
Cdd:smart00564   2 VVLSDGTVYVGSTDGTLYALDAKTGEILWTYK 33
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 39-98 9.59e-03

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 35.21  E-value: 9.59e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907162830  39 KEELWGKLQYLWKSILCLPED---PEDTLkvpansvFLDSGGDSLKSMRLLSEIERLTGTAIP 98
Cdd:COG0236     3 REELEERLAEIIAEVLGVDPEeitPDDSF-------FEDLGLDSLDAVELIAALEEEFGIELP 58
 
Name Accession Description Interval E-value
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 218-369 1.22e-14

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 75.62  E-value: 1.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 218 DENLEKPPLFQQGSPVVgamamALRERWRSDTGKCVDASPLLVRAAVQDkpsTTVYIGSHSHTVKAVDLSSGETRWEQLL 297
Cdd:COG1520    14 EDDEPPPAPLPEFEPSV-----KVKQLWSASVGDGVGKGYSRLAPAVAG---DRVYAADADGRVAALDAATGKELWRVDL 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907162830 298 GDRIesSACVSKCGNFIVVGCYNGLVYVLKSNSGEKYWTFTTEDAVKSSPAVDptTGLIYVGSHDQHAYALD 369
Cdd:COG1520    86 GEPL--SGGVGADGGLVVVGTEDGEVIALDADDGEELWRARLSSEVLAAPAVA--GGRVVVRTGDGRVYALD 153
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 280-500 3.77e-14

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 72.05  E-value: 3.77e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 280 TVKAVDLSSGETRWEQLLGDRIESSACVSkcGNFIVVGCYNGLVYVLKSNSGEKYWTFTTEDAVKSSPAVDptTGLIYVG 359
Cdd:pfam13360   4 VVTALDAATGAELWRVDLETGLGGGVAVD--GGRLFVATGGGQLVALDAATGKLLWRQTLSGEVLGAPLVA--GGRVFVV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 360 SHDQHAYALDIYEKKCVWKL---NCEGALFSSPCVSLSPHHLYCATLGGLLLALNPASGSTVWKRSCGKP---------- 426
Cdd:pfam13360  80 AGDGSLIALDAADGRRLWSYqrsGEPLALRSSGSPAVVGDTVVAGFSSGKLVALDPATGKVRWEAPLAAPrgtnelerlv 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907162830 427 -LFSSPRCYQQYICIGCVDGSLLCF-THSGEQVWRFAAGGPifSSPCVsaAEQEIFFGSHDCFIYCCS-KEGHLRWK 500
Cdd:pfam13360 160 dITGTPVVAGGRVFASAYQGRLVAFdAATGRRLWTREISGP--NGPIL--DGDLLYVVSDDGELYALDrATGAVVWK 232
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 218-369 2.37e-12

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 68.81  E-value: 2.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 218 DENLEKPPLFQQGSPVVgamamALRERWRSDTGKCVDASPLLVRAAVQDkpsTTVYIGSHSHTVKAVDLSSGETRWEQLL 297
Cdd:TIGR03300  22 EDDEPQPAELPEFQPTV-----KVDQVWSASVGDGVGHYYLRLQPAVAG---GKVYAADADGTVAALDAETGKRLWRVDL 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907162830 298 GDRIesSACVSKCGNFIVVGCYNGLVYVLKSNSGEKYWTFTTEDAVKSSPAVDptTGLIYVGSHDQHAYALD 369
Cdd:TIGR03300  94 DERL--SGGVGADGGLVFVGTEKGEVIALDAEDGKELWRAKLSSEVLSPPLVA--NGLVVVRTNDGRLTALD 161
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 332-578 8.59e-11

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 63.89  E-value: 8.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 332 EKYWTFTTEDAVKSSPAVDptTGLIYVGSHDQHAYALDIYEKKCVWKLNCEGALFSSPCVSLSPHHLYCATLGGLLLALN 411
Cdd:cd10276    19 SKSVGNGGMAGIDLTPVVA--GDMVYAADANGQVSAFNATTGKIIWETSLSGKGFLGGTPAVGNGKIFVGTESGYLYALD 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 412 PASGSTVWKRSCGKPLFSSPRCYQQ-YICIGCVDGSLLCF-THSGEQVWRFAAGGPIFSSPCVSA---AEQEIFFGSHDC 486
Cdd:cd10276    97 AKDGSELWRTEVSDSQLLSPPTYADgKIYVGTGDGRLYYCnAETGKVVWNRTSTAPELSLRGGAApvgAYDVVFVGDGNG 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 487 FIYCCSKE-GHLRWKFETTARVYATP----FAFSNHPRSDDALLAAASTDGKLWVLESRSGELRSVYELpGEVFSSPVVW 561
Cdd:cd10276   177 TVVALNTGtGVDIWEFSVSEPRGRTElprmIDSSVTYVVVGGYLYSTSYQGYLVALDFESGQFLWSRKA-SGGTSTSTDA 255

                         250
                  ....*....|....*..
gi 1907162830 562 ESMLVIGCRNNYIYCLD 578
Cdd:cd10276   256 NGRVYVGDGEGSLYCLD 272
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 320-543 4.05e-09

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 57.41  E-value: 4.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 320 NGLVYVLKSNSGEKYWTFTTEDAVKSSPAVDptTGLIYVGSHDQHAYALDIYEKKCVWKLNCEGALFSSPCVslSPHHLY 399
Cdd:pfam13360   2 DGVVTALDAATGAELWRVDLETGLGGGVAVD--GGRLFVATGGGQLVALDAATGKLLWRQTLSGEVLGAPLV--AGGRVF 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 400 CATLGGLLLALNPASGSTVWKRSCGKPLF-----SSPRCYQQYICIGCVDGSLLCF-THSGEQVW-----------RFAA 462
Cdd:pfam13360  78 VVAGDGSLIALDAADGRRLWSYQRSGEPLalrssGSPAVVGDTVVAGFSSGKLVALdPATGKVRWeaplaaprgtnELER 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 463 GGPIFSSPCVsaAEQEIFFGSHdcfiyccsKEGHLRWKFETTARVYATPFAFSNHPRSDDALLAAASTDGKLWVLESRSG 542
Cdd:pfam13360 158 LVDITGTPVV--AGGRVFASAY--------QGRLVAFDAATGRRLWTREISGPNGPILDGDLLYVVSDDGELYALDRATG 227


                  .
gi 1907162830 543 E 543
Cdd:pfam13360 228 A 228
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 272-579 1.87e-07

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 53.49  E-value: 1.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 272 VYIGSHSHTVKAVDLSSGETRWEQLLGDRIESSACVSKCGNFIVVGCYNGLVYVLKSNSGEKYWTFTTEDAVKSSPavdP 351
Cdd:cd10276    41 VYAADANGQVSAFNATTGKIIWETSLSGKGFLGGTPAVGNGKIFVGTESGYLYALDAKDGSELWRTEVSDSQLLSP---P 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 352 TT--GLIYVGSHDQHAYALDIYEKKCVWKLNC---EGALFSSPCVSLSPHHLYCATLGGLLLALNPASGSTVWKRSCGKP 426
Cdd:cd10276   118 TYadGKIYVGTGDGRLYYCNAETGKVVWNRTStapELSLRGGAAPVGAYDVVFVGDGNGTVVALNTGTGVDIWEFSVSEP 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 427 LFSSPRCYQQYICIGCVDGSLLCFT------------HSGEQVWRFAAGGpIFSSPCVsaAEQEIFFGSHDCFIYCCSKE 494
Cdd:cd10276   198 RGRTELPRMIDSSVTYVVVGGYLYStsyqgylvaldfESGQFLWSRKASG-GTSTSTD--ANGRVYVGDGEGSLYCLDAS 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 495 -GHLRWKFETTARVYATPFAFSnhprSDDALLAAASTDGKLWVLESRSGEL--RSVYELPGEVFSSPVVWESMLVIGCRN 571
Cdd:cd10276   275 tGDELWSQTVLLGRVLSSPAIY----VGVYIYVTDNAEGYLYCLKDNDGLTvaRVEVDYSQYILQGPAVSDGWLYYGTDD 350


                  ....*...
gi 1907162830 572 NYIYCLDL 579
Cdd:cd10276   351 GYLYALTR 358
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 453-568 5.59e-07

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 52.12  E-value: 5.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 453 SGEQVWRFAAGGPIfSSPcVSAAEQEIFFGSHDCFIYCCSKE-GHLRWKFETTARVYATPfafsnhpRSDDALLAAASTD 531
Cdd:COG1520    76 TGKELWRVDLGEPL-SGG-VGADGGLVVVGTEDGEVIALDADdGEELWRARLSSEVLAAP-------AVAGGRVVVRTGD 146

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1907162830 532 GKLWVLESRSGELRSVYELPGEVF-----SSPVVWESMLVIG 568
Cdd:COG1520   147 GRVYALDAATGERLWSYQRPVPALtlrgtSSPVIVGGAVLVG 188
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 261-380 1.46e-06

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 50.70  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 261 RAAVQDkpsTTVYIGSHSHTVKAVDLSSGETRWEQLLGDRIES---------SACVSKCGNFIVVGCYNGLVYVLKSNSG 331
Cdd:PRK11138   64 HPAVAY---NKVYAADRAGLVKALDADTGKEIWSVDLSEKDGWfsknksallSGGVTVAGGKVYIGSEKGQVYALNAEDG 140

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1907162830 332 EKYWTFTTEDAVKSSPAVDptTGLIYVGSHDQHAYALDIYEKKCVWKLN 380
Cdd:PRK11138  141 EVAWQTKVAGEALSRPVVS--DGLVLVHTSNGMLQALNESDGAVKWTVN 187
PQQ_3 pfam13570
PQQ-like domain;
331-368 8.63e-06

PQQ-like domain;


Pssm-ID: 463925 [Multi-domain]  Cd Length: 36  Bit Score: 42.57  E-value: 8.63e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907162830 331 GEKYWTFTTEDAVKSSPAVDptTGLIYVGSHDQHAYAL 368
Cdd:pfam13570   1 GEVLWRFETGGPIVSSPAVA--GGLVYVGTGDGTLYAL 36
WD40 COG2319
WD40 repeat [General function prediction only];
245-539 1.08e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 245 WRSDTGKCV---DASPLLVRAAVQDKPSTTVYIGSHSHTVKAVDLSSGETRWEqLLGDRIE-SSACVSKCGNFIVVGCYN 320
Cdd:COG2319   147 WDLATGKLLrtlTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTGAvRSVAFSPDGKLLASGSAD 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 321 GLVYVLKSNSGEKYWTFTTEDAVKSSPAVDPTTGLIYVGSHDQHAYALDIYEKKCVWKLncEGALFSSPCVSLSP--HHL 398
Cdd:COG2319   226 GTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL--TGHSGGVNSVAFSPdgKLL 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 399 ycatlgglllalnpASGS-----TVWKRSCGKPLfssprcyqqyicigcvdgsllcFTHSGEQVWRFAAggpifsspCVS 473
Cdd:COG2319   304 --------------ASGSddgtvRLWDLATGKLL----------------------RTLTGHTGAVRSV--------AFS 339

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907162830 474 AAEQEIFFGSHDcfiyccskeGHLR-WKFET----------TARVYAtpFAFSnhprSDDALLAAASTDG--KLWVLES 539
Cdd:COG2319   340 PDGKTLASGSDD---------GTVRlWDLATgellrtltghTGAVTS--VAFS----PDGRTLASGSADGtvRLWDLAT 403
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 271-378 1.40e-05

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 46.63  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 271 TVYIGSHSHTVKAVDLSSGETRWEQLL-----GDRIE-----SSACVSKCGNFIVVGcYNGLVYVLKSNSGEKYWTftte 340
Cdd:pfam13360 120 TVVAGFSSGKLVALDPATGKVRWEAPLaaprgTNELErlvdiTGTPVVAGGRVFASA-YQGRLVAFDAATGRRLWT---- 194

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1907162830 341 DAVKSSPAVDPTTGLIYVGSHDQHAYALDIYEKKCVWK 378
Cdd:pfam13360 195 REISGPNGPILDGDLLYVVSDDGELYALDRATGAVVWK 232
WD40 COG2319
WD40 repeat [General function prediction only];
226-535 1.56e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 1.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 226 LFQQGSPVVGAMAMALRERWRSDTGKCVDASPLL---VRAAVQDKPSTTVYIGSHSHTVKAVDLSSGETRWEQLLGDRIE 302
Cdd:COG2319    44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHtaaVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 303 SSACVSKCGNFIVVGCYNGLVYVLKSNSGEKYWTFTTEDAVKSSPAVDPTTGLIYVGSHDQHAYALDIYEKKCVWKLNCE 382
Cdd:COG2319   124 RSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 383 GALFSSpcVSLSP--HHLycatlgglllalnpASGST-----VWKRSCGKPLFS-------------SPrcYQQYICIGC 442
Cdd:COG2319   204 TGAVRS--VAFSPdgKLL--------------ASGSAdgtvrLWDLATGKLLRTltghsgsvrsvafSP--DGRLLASGS 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 443 VDGSLLCF-THSGEQVWRFAAGGPIFSSPCVSAAEQEIFFGSHDcfiyccskeGHLR-WKFET----------TARVYAt 510
Cdd:COG2319   266 ADGTVRLWdLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD---------GTVRlWDLATgkllrtltghTGAVRS- 335

                         330       340
                  ....*....|....*....|....*..
gi 1907162830 511 pFAFSnhprSDDALLAAASTDG--KLW 535
Cdd:COG2319   336 -VAFS----PDGKTLASGSDDGtvRLW 357
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 49-98 2.81e-05

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 42.17  E-value: 2.81e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907162830  49 LWKSILCLPEDPedtlkVPANSVFLDSGGDSLKSMRLLSEIERLTGTAIP 98
Cdd:pfam00550   6 LLAEVLGVPAEE-----IDPDTDLFDLGLDSLLAVELIARLEEEFGVEIP 50
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 411-582 7.11e-05

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 45.31  E-value: 7.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 411 NPASGSTVWKRSCGKplfsSPRCYQQYICIGCVDGSLlcFT------------HSGEQVWRFAAGGPIfsSPCVSAAEQE 478
Cdd:TIGR03300  36 PTVKVDQVWSASVGD----GVGHYYLRLQPAVAGGKV--YAadadgtvaaldaETGKRLWRVDLDERL--SGGVGADGGL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 479 IFFGSHDCFIYCCSKE-GHLRWKFETTARVYATPFafsnhprSDDALLAAASTDGKLWVLESRSGELRSVYELPGEVF-- 555
Cdd:TIGR03300 108 VFVGTEKGEVIALDAEdGKELWRAKLSSEVLSPPL-------VANGLVVVRTNDGRLTALDAATGERLWTYSRVTPPLtl 180

                         170       180       190
                  ....*....|....*....|....*....|
gi 1907162830 556 ---SSPVVWESMLVIGCRNNYIYCLDLLCG 582
Cdd:TIGR03300 181 rgsASPVIADGGVLVGFAGGKLVALDLQTG 210
PQQ_DH_like cd00216
PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases ...
 249-359 8.87e-05

PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases with pyrroloquinoline quinone (PQQ) as a cofactor, such as ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller, and the family also includes distantly related proteins which are not enzymatically active and do not bind PQQ.


Pssm-ID: 199833 [Multi-domain]  Cd Length: 434  Bit Score: 45.29  E-value: 8.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 249 TGKCVDASPLLVRAAVQDkpsTTVYIGSHSHTVKAVDLSSGETRWEQLLGDRIESSAcVSKCGNFIVVGCYNGLVYVLKS 328
Cdd:cd00216   296 NGELVSARPLVPDSYDPD---RELFYVPANGRIMALDPVTGVVVWEKSELHPLLGGP-LSTAGNLVFVGTSDGYLKAYNA 371

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1907162830 329 NSGEKYWTFTTEDAVKSSPAVDPTTGLIYVG 359
Cdd:cd00216   372 DTGEKLWQQKVPSGFQAEPVTYEVDGEQYVL 402
Luminal_IRE1_like cd09213
The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; The ...
 443-548 3.18e-04

The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; The Luminal domain is a dimerization domain present in Inositol-requiring protein 1 (IRE1), eukaryotic translation Initiation Factor 2-Alpha Kinase 3 (EIF2AK3), and similar proteins. IRE1 and EIF2AK3 are serine/threonine protein kinases (STKs) and are type I transmembrane proteins that are localized in the endoplasmic reticulum (ER). They are kinase receptors that are activated through the release of BiP, a chaperone bound to their luminal domains under unstressed conditions. This results in dimerization through their luminal domains, allowing trans-autophosphorylation of their kinase domains and activation. They play roles in the signaling of the unfolded protein response (UPR), which is activated when protein misfolding is detected in the ER in order to decrease the synthesis of new proteins and increase the capacity of the ER to cope with the stress. IRE1, also called Endoplasmic reticulum (ER)-to-nucleus signaling protein (or ERN), contains an endoribonuclease domain in its cytoplasmic side and acts as an ER stress sensor. It is the oldest and most conserved component of the UPR in eukaryotes. Its activation results in the cleavage of its mRNA substrate, HAC1 in yeast and Xbp1 in metazoans, promoting a splicing event that enables translation into a transcription factor which activates the UPR. EIF2AK3, also called PKR-like Endoplasmic Reticulum Kinase (PERK), phosphorylates the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. It functions as the central regulator of translational control during the UPR pathway. In addition to the eIF-2 alpha subunit, EIF2AK3 also phosphorylates Nrf2, a leucine zipper transcription factor which regulates cellular redox status and promotes cell survival during the UPR.


Pssm-ID: 188873 [Multi-domain]  Cd Length: 312  Bit Score: 43.25  E-value: 3.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 443 VDGSLLCF-THSGEQVWRFAAGGPIFSSPcVSAAEQEIFFGSHDCFI--------YCCSKEGHLRWKFETTAR--VYATP 511
Cdd:cd09213     7 LDGTIYAVdASSGEIQWSFDGGGPLYSSY-QSSRDGNAESSSTMLIPsldgdgnlYQHDKGHGSLQRLPLTIEdlVEASP 85

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1907162830 512 FAFsnHPRSDDALLaAASTDGKLWVLESRSGELRSVY 548
Cdd:cd09213    86 LVS--DTNEDDVVV-VGSKRTSVFALDAKTGKIIKTY 119
PQQ smart00564
beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline ...
 307-338 1.27e-03

beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline quinone (PQQ) as cofactor, in Ire1p-like Ser/Thr kinases, and in prokaryotic dehydrogenases.


Pssm-ID: 128836 [Multi-domain]  Cd Length: 33  Bit Score: 36.36  E-value: 1.27e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907162830  307 VSKCGNFIVVGCYNGLVYVLKSNSGEKYWTFT 338
Cdd:smart00564   2 VVLSDGTVYVGSTDGTLYALDAKTGEILWTYK 33
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 271-370 1.35e-03

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 41.34  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 271 TVYIGSHSHTVKAVDLSSGETRWEQ--LLGDRIESSACVskcGNFIVVGCYNGLVYVLKSNSGEkywtF-----TTEDAV 343
Cdd:COG1520   273 NLYVTDDDGRVWALDRRNGAELWKQdaLLYRGLTAPVVL---GDYVVVGDFEGYLHWLSRDDGS----LvarlrVDGSGI 345

                          90       100
                  ....*....|....*....|....*..
gi 1907162830 344 KSSPAVDPTTglIYVGSHDQHAYALDI 370
Cdd:COG1520   346 RAAPVVVGDT--LYVQTRDGTLAALRL 370
PQQ_3 pfam13570
PQQ-like domain;
454-490 3.40e-03

PQQ-like domain;


Pssm-ID: 463925 [Multi-domain]  Cd Length: 36  Bit Score: 35.26  E-value: 3.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907162830 454 GEQVWRFAAGGPIFSSPCVsaAEQEIFFGSHDCFIYC 490
Cdd:pfam13570   1 GEVLWRFETGGPIVSSPAV--AGGLVYVGTGDGTLYA 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
270-364 3.67e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.29  E-value: 3.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 270 TTVYI-GSHSHTVKAVDLSSGETRWEQLLGDRIESSACVSKCGNFIVVGCYNGLVYVLKSNSGEKYWTFTTEDavksSP- 347
Cdd:COG3391    80 RRLYVaNSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGA----GPh 155

                          90
                  ....*....|....*....
gi 1907162830 348 --AVDPTTGLIYVGSHDQH 364
Cdd:COG3391   156 giAVDPDGKRLYVANSGSN 174
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 262-347 3.80e-03

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 39.97  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 262 AAVQDKPSTTVYIGShshtVKAVDLSSGETRWEQllgdRIESSAC---VSKCGNFIVVGCYNGLVYVLKSNSGEKYWTFT 338
Cdd:cd10277   403 AGFTIKPPFEDHIGE----LQAIDPTTGKKVWEH----KTPLPLWggvLTTAGGLVFTGTPDGYFRAFDAKTGKELWEFQ 474


                  ....*....
gi 1907162830 339 TEDAVKSSP 347
Cdd:cd10277   475 TGSGIIGPP 483
PQQ_DH_like cd00216
PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases ...
 335-465 4.08e-03

PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases with pyrroloquinoline quinone (PQQ) as a cofactor, such as ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller, and the family also includes distantly related proteins which are not enzymatically active and do not bind PQQ.


Pssm-ID: 199833 [Multi-domain]  Cd Length: 434  Bit Score: 39.90  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 335 WTFTTEDA----VKSSPAVdpTTGLIYVGSHDQHAYALDIYEKKCVWKLNCE--GALFSSPC------VSLSPHHLYCAT 402
Cdd:cd00216    11 WSFSTGDGgnrgSELTPIV--VDGVMYATTSFSRVFALDADDGKEIWSYDPAlkDGWFEACCdlvnrgVAVWGGKVYIGV 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907162830 403 LGGLLLALNPASGSTVWKRS-----CGKPLFSSPRCYQQYICIGC------VDGSLLCF-THSGEQVWRFAAGGP 465
Cdd:cd00216    89 LDGRVYALNAETGKVAWKVKnadvlGGYTATSAPVVVDGLVIIGSsgdefgVRGYLTAYdVATGEEKWRFYLVMP 163
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 411-545 4.51e-03

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 39.80  E-value: 4.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 411 NPASGSTVWKRSCGKPLFSSPRCYQQYICIGCVDGSLLCF-THSGEQVWRFAAGGPIFSSPCVsaAEQEIFFGSHDCFIY 489
Cdd:COG1520    73 DAATGKELWRVDLGEPLSGGVGADGGLVVVGTEDGEVIALdADDGEELWRARLSSEVLAAPAV--AGGRVVVRTGDGRVY 150

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907162830 490 CCSKE-GHLRWKFETTA-----RVYATPFAfsnhprSDDALLAAAStDGKLWVLESRSGELR 545
Cdd:COG1520   151 ALDAAtGERLWSYQRPVpaltlRGTSSPVI------VGGAVLVGFA-NGKLVALDLANGQPL 205
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 520-578 4.67e-03

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 39.41  E-value: 4.67e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907162830 520 SDDALLAAASTDGKLWVLESRSGELRSVYELPGEVFSSPVVWESMLVIGCRNNYIYCLD 578
Cdd:COG1520    95 ADGGLVVVGTEDGEVIALDADDGEELWRARLSSEVLAAPAVAGGRVVVRTGDGRVYALD 153
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 245-376 6.43e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 38.86  E-value: 6.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162830 245 WRSDTGKCVDA-----SPllVRAAVQDKPSTTVYIGSHSHTVKAVDLSSGETRWeQLLG--DRIeSSACVSKCGNFIVVG 317
Cdd:cd00200   120 WDVETGKCLTTlrghtDW--VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA-TLTGhtGEV-NSVAFSPDGEKLLSS 195

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907162830 318 CYNGLVYVLKSNSGEKYWTFTTEDAVKSSPAVDPTTGLIYVGSHDQHAYALDIYEKKCV 376
Cdd:cd00200   196 SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECV 254
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 39-98 9.59e-03

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 35.21  E-value: 9.59e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907162830  39 KEELWGKLQYLWKSILCLPED---PEDTLkvpansvFLDSGGDSLKSMRLLSEIERLTGTAIP 98
Cdd:COG0236     3 REELEERLAEIIAEVLGVDPEeitPDDSF-------FEDLGLDSLDAVELIAALEEEFGIELP 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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