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Conserved domains on  [gi|1907161072|ref|XP_036020781|]
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mismatch repair endonuclease PMS2 isoform X10 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
1-105 9.48e-29

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 115.82  E-value: 9.48e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161072   1 MRHGEGRMRWlTTNEEYTGHWEKGIQNGFGTHTWflkriPNSqyplrNEYIGEFVNGFRHGQGKFYYASGAMYEGEWASN 80
Cdd:COG4642   158 KPHGQGTLTY-ADGDRYEGEFKNGKRHGQGTLTY-----ANG-----DVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNG 226

                          90       100
                  ....*....|....*....|....*
gi 1907161072  81 KKQGRGRMTFKNGHVYEGLFSNDHI 105
Cdd:COG4642   227 KRHGQGTLTYADGDRYEGEFKNGKR 251
vATP-synt_E super family cl23750
ATP synthase (E/31 kDa) subunit; This family includes the vacuolar ATP synthase E subunit, as ...
 548-595 8.01e-04

ATP synthase (E/31 kDa) subunit; This family includes the vacuolar ATP synthase E subunit, as well as the archaebacterial ATP synthase E subunit.


The actual alignment was detected with superfamily member pfam01991:

Pssm-ID: 419987 [Multi-domain]  Cd Length: 199  Bit Score: 41.21  E-value: 8.01e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907161072 548 AYKREEMLKEKVKENQLQEAELAQQRQIENEELEARLNIL--REE-------EARKQ 595
Cdd:pfam01991  28 LVQEAEEKIDEIYEKKEKQAEMQKKIIISNAKNEARLKVLeaREEildevfnEAEKK 84
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
1-105 9.48e-29

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 115.82  E-value: 9.48e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161072   1 MRHGEGRMRWlTTNEEYTGHWEKGIQNGFGTHTWflkriPNSqyplrNEYIGEFVNGFRHGQGKFYYASGAMYEGEWASN 80
Cdd:COG4642   158 KPHGQGTLTY-ADGDRYEGEFKNGKRHGQGTLTY-----ANG-----DVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNG 226

                          90       100
                  ....*....|....*....|....*
gi 1907161072  81 KKQGRGRMTFKNGHVYEGLFSNDHI 105
Cdd:COG4642   227 KRHGQGTLTYADGDRYEGEFKNGKR 251
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 4-98 1.78e-11

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 67.17  E-value: 1.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161072   4 GEGRMRWlTTNEEYTGHWEKGIQNGFGTHTWflkripnsqyPLRNEYIGEFVNGFRHGQGKFYYASGAMYEGEWASNKKQ 83
Cdd:PLN03185   22 GPGKYLW-SDGCMYEGEWRRGMRHGNGKISW----------PSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKH 90

                          90
                  ....*....|....*
gi 1907161072  84 GRGRMTFKNGHVYEG 98
Cdd:PLN03185   91 GLGYQRYPNGDVFEG 105
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 50-72 7.44e-06

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 42.78  E-value: 7.44e-06
                          10        20
                  ....*....|....*....|...
gi 1907161072  50 YIGEFVNGFRHGQGKFYYASGAM 72
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
48-68 1.08e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 39.25  E-value: 1.08e-04
                           10        20
                   ....*....|....*....|.
gi 1907161072   48 NEYIGEFVNGFRHGQGKFYYA 68
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYA 21
vATP-synt_E pfam01991
ATP synthase (E/31 kDa) subunit; This family includes the vacuolar ATP synthase E subunit, as ...
 548-595 8.01e-04

ATP synthase (E/31 kDa) subunit; This family includes the vacuolar ATP synthase E subunit, as well as the archaebacterial ATP synthase E subunit.


Pssm-ID: 396537 [Multi-domain]  Cd Length: 199  Bit Score: 41.21  E-value: 8.01e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907161072 548 AYKREEMLKEKVKENQLQEAELAQQRQIENEELEARLNIL--REE-------EARKQ 595
Cdd:pfam01991  28 LVQEAEEKIDEIYEKKEKQAEMQKKIIISNAKNEARLKVLeaREEildevfnEAEKK 84
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
1-105 9.48e-29

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 115.82  E-value: 9.48e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161072   1 MRHGEGRMRWlTTNEEYTGHWEKGIQNGFGTHTWflkriPNSqyplrNEYIGEFVNGFRHGQGKFYYASGAMYEGEWASN 80
Cdd:COG4642   158 KPHGQGTLTY-ADGDRYEGEFKNGKRHGQGTLTY-----ANG-----DVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNG 226

                          90       100
                  ....*....|....*....|....*
gi 1907161072  81 KKQGRGRMTFKNGHVYEGLFSNDHI 105
Cdd:COG4642   227 KRHGQGTLTYADGDRYEGEFKNGKR 251
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
1-102 1.23e-27

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 112.74  E-value: 1.23e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161072   1 MRHGEGRMRWlTTNEEYTGHWEKGIQNGFGTHTWflkriPNSQYplrneYIGEFVNGFRHGQGKFYYASGAMYEGEWASN 80
Cdd:COG4642   181 KRHGQGTLTY-ANGDVYEGEFKNGQRHGQGTYTY-----ADGDR-----YEGEFKNGKRHGQGTLTYADGDRYEGEFKNG 249

                          90       100
                  ....*....|....*....|..
gi 1907161072  81 KKQGRGRMTFKNGHVYEGLFSN 102
Cdd:COG4642   250 KRHGQGTMTYADGSVYEGEWKN 271
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
4-104 1.43e-21

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 95.02  E-value: 1.43e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161072   4 GEGRMRWLTTNEEYTGHWEKGIQNGFGTHTWFLKRIPNSQ----YPLRNEYIGEFVNGFRHGQGKFYYASGAMYEGEWAS 79
Cdd:COG4642   100 GGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGgiytFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKN 179

                          90       100
                  ....*....|....*....|....*
gi 1907161072  80 NKKQGRGRMTFKNGHVYEGLFSNDH 104
Cdd:COG4642   180 GKRHGQGTLTYANGDVYEGEFKNGQ 204
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 4-98 1.78e-11

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 67.17  E-value: 1.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161072   4 GEGRMRWlTTNEEYTGHWEKGIQNGFGTHTWflkripnsqyPLRNEYIGEFVNGFRHGQGKFYYASGAMYEGEWASNKKQ 83
Cdd:PLN03185   22 GPGKYLW-SDGCMYEGEWRRGMRHGNGKISW----------PSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKH 90

                          90
                  ....*....|....*
gi 1907161072  84 GRGRMTFKNGHVYEG 98
Cdd:PLN03185   91 GLGYQRYPNGDVFEG 105
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 1-98 1.11e-10

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 64.85  E-value: 1.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161072   1 MRHGEGRMRWlTTNEEYTGHWEKGIQNGFGTHT----------WFLKR---IPNSQYPLRNEYIGEFVNGFRHGQGKFYY 67
Cdd:PLN03185   42 MRHGNGKISW-PSGATYEGEFSGGYMHGSGTYTgtdgttykgrWRLNLkhgLGYQRYPNGDVFEGSWIQGLQEGPGKYTW 120

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1907161072  68 ASGAMYEGEWASNKKQGRGRMTFKNGHVYEG 98
Cdd:PLN03185  121 ANGNVYLGDMKGGKMSGKGTLTWVSGDSYEG 151
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 1-157 2.24e-10

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 63.70  E-value: 2.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161072   1 MRHGEGRMRWlTTNEEYTGHWEKGIQNGFGTHTWflkripnsqyPLRNEYIGEFVNGFRHGQGKFYYASGAMYEGEWASN 80
Cdd:PLN03185   88 LKHGLGYQRY-PNGDVFEGSWIQGLQEGPGKYTW----------ANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDG 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161072  81 KKQGRGRMTFKNGHVYEGLFS---NDHIAQFF-------ETEMDYSQSLDRWSDASQRSRQPRGSSV-----------SA 139
Cdd:PLN03185  157 MMHGFGVYTWSDGGCYVGTWTrglKDGKGVFYpagsrvpAVQEFYLNALRKRGVLPDLRRQNQVLSShnseqlsrgvsSD 236

                         170
                  ....*....|....*...
gi 1907161072 140 VREPETLRKLDGSESRSV 157
Cdd:PLN03185  237 KLSKGSLLPLEQSRNRNV 254
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 37-105 1.51e-08

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 57.92  E-value: 1.51e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907161072  37 KRIPNSQYplrneYIGEFVNGFRHGQGKFYYASGAMYEGEWASNKKQGRGRMTFKNGHVYEGLFSNDHI 105
Cdd:PLN03185    3 LVLSNGDF-----YSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYM 66
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
14-104 1.05e-06

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 50.73  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161072  14 NEEYTGHWEKGIQNGFGTHTWFLKRIPNSQYPLRNEYIGEFVNGFRHGQGKFYYASGAMYEGEWASNKKQGRGRMTFKNG 93
Cdd:COG4642    68 GEGGVTAAGGGGGGGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNG 147

                          90
                  ....*....|.
gi 1907161072  94 HVYEGLFSNDH 104
Cdd:COG4642   148 DVYEGEFKNGK 158
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 50-72 7.44e-06

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 42.78  E-value: 7.44e-06
                          10        20
                  ....*....|....*....|...
gi 1907161072  50 YIGEFVNGFRHGQGKFYYASGAM 72
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
19-103 2.11e-05

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 45.06  E-value: 2.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161072  19 GHWEKGIQNGFGThTWFlkriPNSQYplrnEYIGEFVNGFRHGQGKFYYASGA-MYEGEWASNKKQGRGRMTFKNGH-VY 96
Cdd:COG2849    83 GTYKNGKLEGEWK-EYY----ENGKL----KSEGNYKNGKLHGEWKEYYENGKlKEEGNYKNGKKDGVWKYYDENGKlVK 153


                  ....*..
gi 1907161072  97 EGLFSND 103
Cdd:COG2849   154 EEEYKNG 160
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
49-103 5.65e-05

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 43.90  E-value: 5.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907161072  49 EYIGEFVNGFRHGQGKFYYASGAM-YEGEWASNKKQGRGRMTFKNGHV-YEGLFSND 103
Cdd:COG2849    80 KSEGTYKNGKLEGEWKEYYENGKLkSEGNYKNGKLHGEWKEYYENGKLkEEGNYKNG 136
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
48-68 1.08e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 39.25  E-value: 1.08e-04
                           10        20
                   ....*....|....*....|.
gi 1907161072   48 NEYIGEFVNGFRHGQGKFYYA 68
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYA 21
vATP-synt_E pfam01991
ATP synthase (E/31 kDa) subunit; This family includes the vacuolar ATP synthase E subunit, as ...
 548-595 8.01e-04

ATP synthase (E/31 kDa) subunit; This family includes the vacuolar ATP synthase E subunit, as well as the archaebacterial ATP synthase E subunit.


Pssm-ID: 396537 [Multi-domain]  Cd Length: 199  Bit Score: 41.21  E-value: 8.01e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907161072 548 AYKREEMLKEKVKENQLQEAELAQQRQIENEELEARLNIL--REE-------EARKQ 595
Cdd:pfam01991  28 LVQEAEEKIDEIYEKKEKQAEMQKKIIISNAKNEARLKVLeaREEildevfnEAEKK 84
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
71-92 1.08e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 36.55  E-value: 1.08e-03
                           10        20
                   ....*....|....*....|..
gi 1907161072   71 AMYEGEWASNKKQGRGRMTFKN 92
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 73-95 1.31e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 36.23  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|...
gi 1907161072  73 YEGEWASNKKQGRGRMTFKNGHV 95
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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