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Conserved domains on  [gi|1907159868|ref|XP_036020628|]
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general transcription factor II-I repeat domain-containing protein 2 isoform X6 [Mus musculus]

Protein Classification

GTF2I repeat domain-containing protein( domain architecture ID 10502978)

GTF2I repeat domain-containing protein similar to Homo sapiens general transcription factor II-I which interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 135-209 2.78e-38

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 133.89  E-value: 2.78e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907159868 135 LRRAVQDHFCLCYRKALGTTAMVPVPYEQMLQDEAAVVVRGLPEGLAFQHPDNYSLATLKWILENKAGISFAVKR 209
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I super family cl08383
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 340-414 1.09e-19

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


The actual alignment was detected with superfamily member pfam02946:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 83.05  E-value: 1.09e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907159868 340 LREQVNDLFSRKFGEAIGVDFPVKVPYRKITFNPGCVVIDGMPPGVVFKAPGYLEISSMRRILDAADFIKFTVIR 414
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
 
Name Accession Description Interval E-value
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 135-209 2.78e-38

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 133.89  E-value: 2.78e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907159868 135 LRRAVQDHFCLCYRKALGTTAMVPVPYEQMLQDEAAVVVRGLPEGLAFQHPDNYSLATLKWILENKAGISFAVKR 209
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 340-414 1.09e-19

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 83.05  E-value: 1.09e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907159868 340 LREQVNDLFSRKFGEAIGVDFPVKVPYRKITFNPGCVVIDGMPPGVVFKAPGYLEISSMRRILDAADFIKFTVIR 414
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
 
Name Accession Description Interval E-value
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 135-209 2.78e-38

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 133.89  E-value: 2.78e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907159868 135 LRRAVQDHFCLCYRKALGTTAMVPVPYEQMLQDEAAVVVRGLPEGLAFQHPDNYSLATLKWILENKAGISFAVKR 209
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 340-414 1.09e-19

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 83.05  E-value: 1.09e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907159868 340 LREQVNDLFSRKFGEAIGVDFPVKVPYRKITFNPGCVVIDGMPPGVVFKAPGYLEISSMRRILDAADFIKFTVIR 414
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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