NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907068716|ref|XP_036020508|]
View 

cadherin-19 isoform X3 [Mus musculus]

Protein Classification

cadherin( domain architecture ID 10182681)

cadherin is a calcium-dependent cell adhesion protein that preferentially interacts with itself in a homophilic manner in connecting cells; it plays a crucial role in tissue morphogenesis and homeostasis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2-93 3.08e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 3.08e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716   2 SPEGTFVIKVTANDADDpstGYHARILYNLERGQP--YFSVEPTTGVIRISSKMDRELQDTYCVIIQAKDMLGQPgaLSG 79
Cdd:cd11304    10 APPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP--LSS 84

                          90
                  ....*....|....
gi 1907068716  80 TTTVSIKLSDINDN 93
Cdd:cd11304    85 TATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 216-307 8.90e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 8.90e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716 216 YILEIPEGKPYGTIVGTVSATDPDR-RQSPMRYYLTG---SKMFDIN-DNGTIITTNMLDREVSAWYNLTVTATETYNVQ 290
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSgneDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 1907068716 291 QISSAHVYVQVFNINDN 307
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 547-606 2.82e-19

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 81.81  E-value: 2.82e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716 547 ANTDPCAPPFDSLQTFAYEGTGSSAGSLSSLASRDTDQEDDFDYLNDLGPRFKRLASMFG 606
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 102-207 8.06e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.59  E-value: 8.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716 102 YRFTISESAPIGTSIGKIMAYDDDIGENAEMEYSI-EDDDSKIFDIiidnDTQEGIVILKKKVDFEQQSYYGIRAKVKNC 180
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|....*..
gi 1907068716 181 HVdeelapaHVNASTTYIKVQVEDEDE 207
Cdd:cd11304    78 GG-------PPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 315-413 1.02e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.48  E-value: 1.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716 315 YETYVCENAESGEIVQIISAIDRDESIEDHHFYfnhSLEDTNNSS-FMLtdnQDNTAVILSNRTgFNLKEEPVFYMIILI 393
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTY---SIVSGNEDGlFSI---DPSTGEITTAKP-LDREEQSSYTLTVTA 74

                          90       100
                  ....*....|....*....|
gi 1907068716 394 ADNGIPSLTSTNTLTIQVCD 413
Cdd:cd11304    75 TDGGGPPLSSTATVTITVLD 94
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2-93 3.08e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 3.08e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716   2 SPEGTFVIKVTANDADDpstGYHARILYNLERGQP--YFSVEPTTGVIRISSKMDRELQDTYCVIIQAKDMLGQPgaLSG 79
Cdd:cd11304    10 APPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP--LSS 84

                          90
                  ....*....|....
gi 1907068716  80 TTTVSIKLSDINDN 93
Cdd:cd11304    85 TATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 216-307 8.90e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 8.90e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716 216 YILEIPEGKPYGTIVGTVSATDPDR-RQSPMRYYLTG---SKMFDIN-DNGTIITTNMLDREVSAWYNLTVTATETYNVQ 290
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSgneDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 1907068716 291 QISSAHVYVQVFNINDN 307
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 547-606 2.82e-19

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 81.81  E-value: 2.82e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716 547 ANTDPCAPPFDSLQTFAYEGTGSSAGSLSSLASRDTDQEDDFDYLNDLGPRFKRLASMFG 606
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 102-207 8.06e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.59  E-value: 8.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716 102 YRFTISESAPIGTSIGKIMAYDDDIGENAEMEYSI-EDDDSKIFDIiidnDTQEGIVILKKKVDFEQQSYYGIRAKVKNC 180
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|....*..
gi 1907068716 181 HVdeelapaHVNASTTYIKVQVEDEDE 207
Cdd:cd11304    78 GG-------PPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 12-95 7.16e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.46  E-value: 7.16e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716   12 TANDADDPStgyHARILYNLERG--QPYFSVEPTTGVIRISSKMDRELQDTYCVIIQAKDMLGQPgaLSGTTTVSIKLSD 89
Cdd:smart00112   1 SATDADSGE---NGKVTYSILSGndDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLD 75


                   ....*.
gi 1907068716   90 INDNKP 95
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
216-301 1.41e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 1.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716 216 YILEIPEGKPYGTIVGTVSATDPDR--RQSPmRYYLTG---SKMFDIN-DNGTIITTNMLDREVSAWYNLTVTATETYNV 289
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLgpNGRI-FYSILGggpGGNFRIDpDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|..
gi 1907068716 290 QQISSAHVYVQV 301
Cdd:pfam00028  80 PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
2-87 8.99e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.33  E-value: 8.99e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716   2 SPEGTFVIKVTANDADDPStgyHARILYNLERGQPY--FSVEPTTGVIRISSKMDRELQDTYCVIIQAKDMLGQPgaLSG 79
Cdd:pfam00028   9 APVGTEVLTVTATDPDLGP---NGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP--LSS 83


                  ....*...
gi 1907068716  80 TTTVSIKL 87
Cdd:pfam00028  84 TATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 234-309 9.42e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.91  E-value: 9.42e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716  234 SATDPDRRQ-SPMRYYLTGS---KMFDINDN-GTIITTNMLDREVSAWYNLTVTATETYNVQQISSAHVYVQVFNINDNA 308
Cdd:smart00112   1 SATDADSGEnGKVTYSILSGnddGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1907068716  309 P 309
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 315-413 1.02e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.48  E-value: 1.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716 315 YETYVCENAESGEIVQIISAIDRDESIEDHHFYfnhSLEDTNNSS-FMLtdnQDNTAVILSNRTgFNLKEEPVFYMIILI 393
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTY---SIVSGNEDGlFSI---DPSTGEITTAKP-LDREEQSSYTLTVTA 74

                          90       100
                  ....*....|....*....|
gi 1907068716 394 ADNGIPSLTSTNTLTIQVCD 413
Cdd:cd11304    75 TDGGGPPLSSTATVTITVLD 94
Cadherin pfam00028
Cadherin domain;
102-203 2.10e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.70  E-value: 2.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716 102 YRFTISESAPIGTSIGKIMAYDDDIGENAEMEYSI-EDDDSKIFDIiidnDTQEGIVILKKKVDFEQQSYYGIRAKVKNC 180
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 1907068716 181 hvdeelaPAHVNASTTYIKVQVE 203
Cdd:pfam00028  77 -------GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 121-209 7.90e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.04  E-value: 7.90e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716  121 AYDDDIGENAEMEYSIEDDDSK-IFDIiidnDTQEGIVILKKKVDFEQQSYYGIRAKVKNCHVdeelapaHVNASTTYIK 199
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDgLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGG-------PPLSSTATVT 70

                           90
                   ....*....|.
gi 1907068716  200 VQVEDE-DEPP 209
Cdd:smart00112  71 ITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
315-412 4.69e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 42.29  E-value: 4.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716 315 YETYVCENAESGEIVQIISAIDRDEsiEDHH--FYFnhSLEDTNNSSFML-TDNQD-NTAVILSnrtgfnlKEEPVFYMI 390
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL--GPNGriFYS--ILGGGPGGNFRIdPDTGDiSTTKPLD-------RESIGEYEL 69

                          90       100
                  ....*....|....*....|...
gi 1907068716 391 ILIA-DNGIPSLTSTNTLTIQVC 412
Cdd:pfam00028  70 TVEAtDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 333-416 7.18e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 35.79  E-value: 7.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716  333 SAIDRDESIEDHHFYfnhSLEDTNNSS-FMLTDNqdnTAVILSNRTgFNLKEEPVFYMIILIADNGIPSLTSTNTLTIQV 411
Cdd:smart00112   1 SATDADSGENGKVTY---SILSGNDDGlFSIDPE---TGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                   ....*
gi 1907068716  412 CDCGD 416
Cdd:smart00112  74 LDVND 78
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2-93 3.08e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 3.08e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716   2 SPEGTFVIKVTANDADDpstGYHARILYNLERGQP--YFSVEPTTGVIRISSKMDRELQDTYCVIIQAKDMLGQPgaLSG 79
Cdd:cd11304    10 APPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP--LSS 84

                          90
                  ....*....|....
gi 1907068716  80 TTTVSIKLSDINDN 93
Cdd:cd11304    85 TATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 216-307 8.90e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 8.90e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716 216 YILEIPEGKPYGTIVGTVSATDPDR-RQSPMRYYLTG---SKMFDIN-DNGTIITTNMLDREVSAWYNLTVTATETYNVQ 290
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSgneDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 1907068716 291 QISSAHVYVQVFNINDN 307
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 547-606 2.82e-19

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 81.81  E-value: 2.82e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716 547 ANTDPCAPPFDSLQTFAYEGTGSSAGSLSSLASRDTDQEDDFDYLNDLGPRFKRLASMFG 606
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 102-207 8.06e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.59  E-value: 8.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716 102 YRFTISESAPIGTSIGKIMAYDDDIGENAEMEYSI-EDDDSKIFDIiidnDTQEGIVILKKKVDFEQQSYYGIRAKVKNC 180
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|....*..
gi 1907068716 181 HVdeelapaHVNASTTYIKVQVEDEDE 207
Cdd:cd11304    78 GG-------PPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 12-95 7.16e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.46  E-value: 7.16e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716   12 TANDADDPStgyHARILYNLERG--QPYFSVEPTTGVIRISSKMDRELQDTYCVIIQAKDMLGQPgaLSGTTTVSIKLSD 89
Cdd:smart00112   1 SATDADSGE---NGKVTYSILSGndDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLD 75


                   ....*.
gi 1907068716   90 INDNKP 95
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
216-301 1.41e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 1.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716 216 YILEIPEGKPYGTIVGTVSATDPDR--RQSPmRYYLTG---SKMFDIN-DNGTIITTNMLDREVSAWYNLTVTATETYNV 289
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLgpNGRI-FYSILGggpGGNFRIDpDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|..
gi 1907068716 290 QQISSAHVYVQV 301
Cdd:pfam00028  80 PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
2-87 8.99e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.33  E-value: 8.99e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716   2 SPEGTFVIKVTANDADDPStgyHARILYNLERGQPY--FSVEPTTGVIRISSKMDRELQDTYCVIIQAKDMLGQPgaLSG 79
Cdd:pfam00028   9 APVGTEVLTVTATDPDLGP---NGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP--LSS 83


                  ....*...
gi 1907068716  80 TTTVSIKL 87
Cdd:pfam00028  84 TATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 234-309 9.42e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.91  E-value: 9.42e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716  234 SATDPDRRQ-SPMRYYLTGS---KMFDINDN-GTIITTNMLDREVSAWYNLTVTATETYNVQQISSAHVYVQVFNINDNA 308
Cdd:smart00112   1 SATDADSGEnGKVTYSILSGnddGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1907068716  309 P 309
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 315-413 1.02e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.48  E-value: 1.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716 315 YETYVCENAESGEIVQIISAIDRDESIEDHHFYfnhSLEDTNNSS-FMLtdnQDNTAVILSNRTgFNLKEEPVFYMIILI 393
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTY---SIVSGNEDGlFSI---DPSTGEITTAKP-LDREEQSSYTLTVTA 74

                          90       100
                  ....*....|....*....|
gi 1907068716 394 ADNGIPSLTSTNTLTIQVCD 413
Cdd:cd11304    75 TDGGGPPLSSTATVTITVLD 94
Cadherin pfam00028
Cadherin domain;
102-203 2.10e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.70  E-value: 2.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716 102 YRFTISESAPIGTSIGKIMAYDDDIGENAEMEYSI-EDDDSKIFDIiidnDTQEGIVILKKKVDFEQQSYYGIRAKVKNC 180
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 1907068716 181 hvdeelaPAHVNASTTYIKVQVE 203
Cdd:pfam00028  77 -------GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 121-209 7.90e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.04  E-value: 7.90e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716  121 AYDDDIGENAEMEYSIEDDDSK-IFDIiidnDTQEGIVILKKKVDFEQQSYYGIRAKVKNCHVdeelapaHVNASTTYIK 199
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDgLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGG-------PPLSSTATVT 70

                           90
                   ....*....|.
gi 1907068716  200 VQVEDE-DEPP 209
Cdd:smart00112  71 ITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
315-412 4.69e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 42.29  E-value: 4.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716 315 YETYVCENAESGEIVQIISAIDRDEsiEDHH--FYFnhSLEDTNNSSFML-TDNQD-NTAVILSnrtgfnlKEEPVFYMI 390
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL--GPNGriFYS--ILGGGPGGNFRIdPDTGDiSTTKPLD-------RESIGEYEL 69

                          90       100
                  ....*....|....*....|...
gi 1907068716 391 ILIA-DNGIPSLTSTNTLTIQVC 412
Cdd:pfam00028  70 TVEAtDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 333-416 7.18e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 35.79  E-value: 7.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068716  333 SAIDRDESIEDHHFYfnhSLEDTNNSS-FMLTDNqdnTAVILSNRTgFNLKEEPVFYMIILIADNGIPSLTSTNTLTIQV 411
Cdd:smart00112   1 SATDADSGENGKVTY---SILSGNDDGlFSIDPE---TGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                   ....*
gi 1907068716  412 CDCGD 416
Cdd:smart00112  74 LDVND 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH