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Conserved domains on  [gi|1907068713|ref|XP_036020507|]
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cadherin-19 isoform X1 [Mus musculus]

Protein Classification

cadherin( domain architecture ID 10182681)

cadherin is a calcium-dependent cell adhesion protein that preferentially interacts with itself in a homophilic manner in connecting cells; it plays a crucial role in tissue morphogenesis and homeostasis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 150-250 3.36e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 3.36e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 150 PYEAIVPEMSPEGTFVIKVTANDADDpstGYHARILYNLERGQP--YFSVEPTTGVIRISSKMDRELQDTYCVIIQAKDM 227
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|...
gi 1907068713 228 LGQPgaLSGTTTVSIKLSDINDN 250
Cdd:cd11304    78 GGPP--LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 373-464 3.50e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 3.50e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 373 YILEIPEGKPYGTIVGTVSATDPDR-RQSPMRYYLTG---SKMFDIN-DNGTIITTNMLDREVSAWYNLTVTATETYNVQ 447
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSgneDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 1907068713 448 QISSAHVYVQVFNINDN 464
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 704-763 2.08e-19

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 82.20  E-value: 2.08e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 704 ANTDPCAPPFDSLQTFAYEGTGSSAGSLSSLASRDTDQEDDFDYLNDLGPRFKRLASMFG 763
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 259-364 3.63e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.13  E-value: 3.63e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 259 YRFTISESAPIGTSIGKIMAYDDDIGENAEMEYSI-EDDDSKIFDIiidnDTQEGIVILKKKVDFEQQSYYGIRAKVKNC 337
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|....*..
gi 1907068713 338 HVdeelapaHVNASTTYIKVQVEDEDE 364
Cdd:cd11304    78 GG-------PPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 50-142 1.10e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713  50 FVVLEEMDDIQCVGKLR-SDLDNGNNS-FQYKLL-GIGAGSFSINERTGEICAIQKLDREEKSLYILRAQVIDTTiGKAV 126
Cdd:cd11304     4 VSVPENAPPGTVVLTVSaTDPDSGENGeVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-GPPL 82

                          90
                  ....*....|....*.
gi 1907068713 127 ETESEFVIRVLDINDN 142
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 472-570 5.54e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.63  E-value: 5.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 472 YETYVCENAESGEIVQIISAIDRDESIEDHHFYfnhSLEDTNNSS-FMLtdnQDNTAVILSNRTgFNLKEEPVFYMIILI 550
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTY---SIVSGNEDGlFSI---DPSTGEITTAKP-LDREEQSSYTLTVTA 74

                          90       100
                  ....*....|....*....|
gi 1907068713 551 ADNGIPSLTSTNTLTIQVCD 570
Cdd:cd11304    75 TDGGGPPLSSTATVTITVLD 94
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 150-250 3.36e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 3.36e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 150 PYEAIVPEMSPEGTFVIKVTANDADDpstGYHARILYNLERGQP--YFSVEPTTGVIRISSKMDRELQDTYCVIIQAKDM 227
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|...
gi 1907068713 228 LGQPgaLSGTTTVSIKLSDINDN 250
Cdd:cd11304    78 GGPP--LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 373-464 3.50e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 3.50e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 373 YILEIPEGKPYGTIVGTVSATDPDR-RQSPMRYYLTG---SKMFDIN-DNGTIITTNMLDREVSAWYNLTVTATETYNVQ 447
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSgneDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 1907068713 448 QISSAHVYVQVFNINDN 464
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 704-763 2.08e-19

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 82.20  E-value: 2.08e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 704 ANTDPCAPPFDSLQTFAYEGTGSSAGSLSSLASRDTDQEDDFDYLNDLGPRFKRLASMFG 763
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 259-364 3.63e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.13  E-value: 3.63e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 259 YRFTISESAPIGTSIGKIMAYDDDIGENAEMEYSI-EDDDSKIFDIiidnDTQEGIVILKKKVDFEQQSYYGIRAKVKNC 337
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|....*..
gi 1907068713 338 HVdeelapaHVNASTTYIKVQVEDEDE 364
Cdd:cd11304    78 GG-------PPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 169-252 2.85e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 2.85e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713  169 TANDADDPStgyHARILYNLERG--QPYFSVEPTTGVIRISSKMDRELQDTYCVIIQAKDMLGQPgaLSGTTTVSIKLSD 246
Cdd:smart00112   1 SATDADSGE---NGKVTYSILSGndDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLD 75


                   ....*.
gi 1907068713  247 INDNKP 252
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
151-244 1.85e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 1.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 151 YEAIVPEMSPEGTFVIKVTANDADDPStgyHARILYNLERGQPY--FSVEPTTGVIRISSKMDRELQDTYCVIIQAKDML 228
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*.
gi 1907068713 229 GQPgaLSGTTTVSIKL 244
Cdd:pfam00028  78 GPP--LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 50-142 1.10e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713  50 FVVLEEMDDIQCVGKLR-SDLDNGNNS-FQYKLL-GIGAGSFSINERTGEICAIQKLDREEKSLYILRAQVIDTTiGKAV 126
Cdd:cd11304     4 VSVPENAPPGTVVLTVSaTDPDSGENGeVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-GPPL 82

                          90
                  ....*....|....*.
gi 1907068713 127 ETESEFVIRVLDINDN 142
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
373-458 8.09e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 8.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 373 YILEIPEGKPYGTIVGTVSATDPDR--RQSPmRYYLTG---SKMFDIN-DNGTIITTNMLDREVSAWYNLTVTATETYNV 446
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLgpNGRI-FYSILGggpGGNFRIDpDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|..
gi 1907068713 447 QQISSAHVYVQV 458
Cdd:pfam00028  80 PLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 67-144 9.39e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.69  E-value: 9.39e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713   67 SDLDNGNNS-FQYKLL-GIGAGSFSINERTGEICAIQKLDREEKSLYILRAQVIDTTiGKAVETESEFVIRVLDINDNEP 144
Cdd:smart00112   3 TDADSGENGkVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 391-466 4.69e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 4.69e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713  391 SATDPDRRQ-SPMRYYLTGS---KMFDINDN-GTIITTNMLDREVSAWYNLTVTATETYNVQQISSAHVYVQVFNINDNA 465
Cdd:smart00112   1 SATDADSGEnGKVTYSILSGnddGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1907068713  466 P 466
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 472-570 5.54e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.63  E-value: 5.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 472 YETYVCENAESGEIVQIISAIDRDESIEDHHFYfnhSLEDTNNSS-FMLtdnQDNTAVILSNRTgFNLKEEPVFYMIILI 550
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTY---SIVSGNEDGlFSI---DPSTGEITTAKP-LDREEQSSYTLTVTA 74

                          90       100
                  ....*....|....*....|
gi 1907068713 551 ADNGIPSLTSTNTLTIQVCD 570
Cdd:cd11304    75 TDGGGPPLSSTATVTITVLD 94
Cadherin pfam00028
Cadherin domain;
259-360 1.38e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 1.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 259 YRFTISESAPIGTSIGKIMAYDDDIGENAEMEYSI-EDDDSKIFDIiidnDTQEGIVILKKKVDFEQQSYYGIRAKVKNC 337
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 1907068713 338 hvdeelaPAHVNASTTYIKVQVE 360
Cdd:pfam00028  77 -------GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 278-366 4.04e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.20  E-value: 4.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713  278 AYDDDIGENAEMEYSIEDDDSK-IFDIiidnDTQEGIVILKKKVDFEQQSYYGIRAKVKNCHVdeelapaHVNASTTYIK 356
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDgLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGG-------PPLSSTATVT 70

                           90
                   ....*....|.
gi 1907068713  357 VQVEDE-DEPP 366
Cdd:smart00112  71 ITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
48-137 2.89e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.84  E-value: 2.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713  48 RPFVVLEEMDDIQCVGKLR-SDLDNGNNS-FQYKLL-GIGAGSFSINERTGEICAIQKLDREEKSLYILRAQVIDTTiGK 124
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTaTDPDLGPNGrIFYSILgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG-GP 79

                          90
                  ....*....|...
gi 1907068713 125 AVETESEFVIRVL 137
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
472-569 3.02e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 3.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 472 YETYVCENAESGEIVQIISAIDRDEsiEDHH--FYFnhSLEDTNNSSFML-TDNQD-NTAVILSnrtgfnlKEEPVFYMI 547
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL--GPNGriFYS--ILGGGPGGNFRIdPDTGDiSTTKPLD-------RESIGEYEL 69

                          90       100
                  ....*....|....*....|...
gi 1907068713 548 ILIA-DNGIPSLTSTNTLTIQVC 569
Cdd:pfam00028  70 TVEAtDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 490-573 4.59e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 36.56  E-value: 4.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713  490 SAIDRDESIEDHHFYfnhSLEDTNNSS-FMLTDNqdnTAVILSNRTgFNLKEEPVFYMIILIADNGIPSLTSTNTLTIQV 568
Cdd:smart00112   1 SATDADSGENGKVTY---SILSGNDDGlFSIDPE---TGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                   ....*
gi 1907068713  569 CDCGD 573
Cdd:smart00112  74 LDVND 78
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 150-250 3.36e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 3.36e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 150 PYEAIVPEMSPEGTFVIKVTANDADDpstGYHARILYNLERGQP--YFSVEPTTGVIRISSKMDRELQDTYCVIIQAKDM 227
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|...
gi 1907068713 228 LGQPgaLSGTTTVSIKLSDINDN 250
Cdd:cd11304    78 GGPP--LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 373-464 3.50e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 3.50e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 373 YILEIPEGKPYGTIVGTVSATDPDR-RQSPMRYYLTG---SKMFDIN-DNGTIITTNMLDREVSAWYNLTVTATETYNVQ 447
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSgneDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 1907068713 448 QISSAHVYVQVFNINDN 464
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 704-763 2.08e-19

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 82.20  E-value: 2.08e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 704 ANTDPCAPPFDSLQTFAYEGTGSSAGSLSSLASRDTDQEDDFDYLNDLGPRFKRLASMFG 763
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 259-364 3.63e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.13  E-value: 3.63e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 259 YRFTISESAPIGTSIGKIMAYDDDIGENAEMEYSI-EDDDSKIFDIiidnDTQEGIVILKKKVDFEQQSYYGIRAKVKNC 337
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|....*..
gi 1907068713 338 HVdeelapaHVNASTTYIKVQVEDEDE 364
Cdd:cd11304    78 GG-------PPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 169-252 2.85e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 2.85e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713  169 TANDADDPStgyHARILYNLERG--QPYFSVEPTTGVIRISSKMDRELQDTYCVIIQAKDMLGQPgaLSGTTTVSIKLSD 246
Cdd:smart00112   1 SATDADSGE---NGKVTYSILSGndDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLD 75


                   ....*.
gi 1907068713  247 INDNKP 252
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
151-244 1.85e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 1.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 151 YEAIVPEMSPEGTFVIKVTANDADDPStgyHARILYNLERGQPY--FSVEPTTGVIRISSKMDRELQDTYCVIIQAKDML 228
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*.
gi 1907068713 229 GQPgaLSGTTTVSIKL 244
Cdd:pfam00028  78 GPP--LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 50-142 1.10e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713  50 FVVLEEMDDIQCVGKLR-SDLDNGNNS-FQYKLL-GIGAGSFSINERTGEICAIQKLDREEKSLYILRAQVIDTTiGKAV 126
Cdd:cd11304     4 VSVPENAPPGTVVLTVSaTDPDSGENGeVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-GPPL 82

                          90
                  ....*....|....*.
gi 1907068713 127 ETESEFVIRVLDINDN 142
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
373-458 8.09e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 8.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 373 YILEIPEGKPYGTIVGTVSATDPDR--RQSPmRYYLTG---SKMFDIN-DNGTIITTNMLDREVSAWYNLTVTATETYNV 446
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLgpNGRI-FYSILGggpGGNFRIDpDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|..
gi 1907068713 447 QQISSAHVYVQV 458
Cdd:pfam00028  80 PLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 67-144 9.39e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.69  E-value: 9.39e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713   67 SDLDNGNNS-FQYKLL-GIGAGSFSINERTGEICAIQKLDREEKSLYILRAQVIDTTiGKAVETESEFVIRVLDINDNEP 144
Cdd:smart00112   3 TDADSGENGkVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 391-466 4.69e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 4.69e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713  391 SATDPDRRQ-SPMRYYLTGS---KMFDINDN-GTIITTNMLDREVSAWYNLTVTATETYNVQQISSAHVYVQVFNINDNA 465
Cdd:smart00112   1 SATDADSGEnGKVTYSILSGnddGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1907068713  466 P 466
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 472-570 5.54e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.63  E-value: 5.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 472 YETYVCENAESGEIVQIISAIDRDESIEDHHFYfnhSLEDTNNSS-FMLtdnQDNTAVILSNRTgFNLKEEPVFYMIILI 550
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTY---SIVSGNEDGlFSI---DPSTGEITTAKP-LDREEQSSYTLTVTA 74

                          90       100
                  ....*....|....*....|
gi 1907068713 551 ADNGIPSLTSTNTLTIQVCD 570
Cdd:cd11304    75 TDGGGPPLSSTATVTITVLD 94
Cadherin pfam00028
Cadherin domain;
259-360 1.38e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 1.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 259 YRFTISESAPIGTSIGKIMAYDDDIGENAEMEYSI-EDDDSKIFDIiidnDTQEGIVILKKKVDFEQQSYYGIRAKVKNC 337
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 1907068713 338 hvdeelaPAHVNASTTYIKVQVE 360
Cdd:pfam00028  77 -------GGPPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 49-142 1.41e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 52.73  E-value: 1.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713  49 PFVVLEEMDDIQCVGKLRSDLDNGNNSFqYKLLGIGA----GSFSINERTGEICAIQKLDREEKSLYILRAQVIDTTiGK 124
Cdd:cd00031     3 DGSAVEGRSRGSFRVSIPTDLIASSGEI-IKISAAGKealpSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLG-AN 80

                          90
                  ....*....|....*...
gi 1907068713 125 AVETESEFVIRVLDINDN 142
Cdd:cd00031    81 VPQTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 278-366 4.04e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.20  E-value: 4.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713  278 AYDDDIGENAEMEYSIEDDDSK-IFDIiidnDTQEGIVILKKKVDFEQQSYYGIRAKVKNCHVdeelapaHVNASTTYIK 356
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDgLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGG-------PPLSSTATVT 70

                           90
                   ....*....|.
gi 1907068713  357 VQVEDE-DEPP 366
Cdd:smart00112  71 ITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
48-137 2.89e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.84  E-value: 2.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713  48 RPFVVLEEMDDIQCVGKLR-SDLDNGNNS-FQYKLL-GIGAGSFSINERTGEICAIQKLDREEKSLYILRAQVIDTTiGK 124
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTaTDPDLGPNGrIFYSILgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG-GP 79

                          90
                  ....*....|...
gi 1907068713 125 AVETESEFVIRVL 137
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
472-569 3.02e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 3.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713 472 YETYVCENAESGEIVQIISAIDRDEsiEDHH--FYFnhSLEDTNNSSFML-TDNQD-NTAVILSnrtgfnlKEEPVFYMI 547
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL--GPNGriFYS--ILGGGPGGNFRIdPDTGDiSTTKPLD-------RESIGEYEL 69

                          90       100
                  ....*....|....*....|...
gi 1907068713 548 ILIA-DNGIPSLTSTNTLTIQVC 569
Cdd:pfam00028  70 TVEAtDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 490-573 4.59e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 36.56  E-value: 4.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068713  490 SAIDRDESIEDHHFYfnhSLEDTNNSS-FMLTDNqdnTAVILSNRTgFNLKEEPVFYMIILIADNGIPSLTSTNTLTIQV 568
Cdd:smart00112   1 SATDADSGENGKVTY---SILSGNDDGlFSIDPE---TGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                   ....*
gi 1907068713  569 CDCGD 573
Cdd:smart00112  74 LDVND 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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