|
Name |
Accession |
Description |
Interval |
E-value |
| MIF4G |
pfam02854 |
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ... |
750-978 |
2.22e-63 |
|
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.
:
Pssm-ID: 397130 Cd Length: 203 Bit Score: 214.53 E-value: 2.22e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 750 FRKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLkvpmadkpgNTVNFR 829
Cdd:pfam02854 1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 830 KLLLNRCQKEFEKdkadddvfekkqkeleaasapeertrlHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCV 909
Cdd:pfam02854 72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907155796 910 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLCN 978
Cdd:pfam02854 125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
|
|
| W2_eIF4G1_like |
cd11559 |
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ... |
1399-1531 |
2.24e-48 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.
:
Pssm-ID: 211397 Cd Length: 134 Bit Score: 168.62 E-value: 2.24e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 1399 EELSQRLEKLIMEEKADDErIFDWVEANLDESQMSSPTFLRALMTAVCKAAIIADcSTFRVDTAVIKQRVPILLKYLDSD 1478
Cdd:cd11559 4 LRVQAELLKLLQEDPNPDE-LYKWIKENVSPELYASPGFVRALMTAVLKYAIEEK-SLPEKEKALLEKYAPLLQKYLDDD 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1907155796 1479 TEKELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPA 1531
Cdd:cd11559 82 EQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
|
|
| MA3 |
pfam02847 |
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ... |
1197-1309 |
9.87e-35 |
|
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.
:
Pssm-ID: 397128 Cd Length: 113 Bit Score: 128.93 E-value: 9.87e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 1197 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1276
Cdd:pfam02847 1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 1907155796 1277 TLELADDMAIDIPHIWLYLAELVTPMLKGGGIS 1309
Cdd:pfam02847 81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
|
|
| PRK07003 super family |
cl35530 |
DNA polymerase III subunit gamma/tau; |
161-325 |
5.83e-06 |
|
DNA polymerase III subunit gamma/tau;
The actual alignment was detected with superfamily member PRK07003:
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 51.00 E-value: 5.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 161 GGGSRNPTPPIGRPASTPTPPQQLPSQV-PEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVL 239
Cdd:PRK07003 368 PGGGVPARVAGAVPAPGARAAAAVGASAvPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDA 447
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 240 SGEKKEQAGQMPETAAGEPTPEPPRTSSPTS-----LPPLARSSlPSPMSAALSSQPLFTAEDKCELPSSKEEDAPPVP- 313
Cdd:PRK07003 448 PVPAKANARASADSRCDERDAQPPADSGSASapasdAPPDAAFE-PAPRAAAPSAATPAAVPDARAPAAASREDAPAAAa 526
|
170
....*....|..
gi 1907155796 314 SPTSCTAASGPS 325
Cdd:PRK07003 527 PPAPEARPPTPA 538
|
|
| W2 super family |
cl17013 |
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ... |
1510-1556 |
1.23e-04 |
|
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.
The actual alignment was detected with superfamily member cd11560:
Pssm-ID: 473053 [Multi-domain] Cd Length: 194 Bit Score: 44.90 E-value: 1.23e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1907155796 1510 LYDEEVISEDAFYKWesSKDPAEQAGKGVALKSVTAFFTWLREAEEE 1556
Cdd:cd11560 150 LYKADVLSEDAILKW--YKKGHSPKGKQVFLKQMEPFVEWLQEAEEE 194
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
5-341 |
7.72e-04 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.54 E-value: 7.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 5 PQARSPFFQRpQIQPPRAAIPNSSPSIRPGVQTPTAVYQANQhimmvnhlpmpyPVTQGHQYCIPqyRHSGPPYVGPPQQ 84
Cdd:PHA03247 2557 PAAPPAAPDR-SVPPPRPAPRPSEPAVTSRARRPDAPPQSAR------------PRAPVDDRGDP--RGPAPPSPLPPDT 2621
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 85 YPVQPPGPGPFYPGPGPGDFANAYGTPfyPSQPVYQSAPiivPTQQQPPPAKREKKTIRIRDPNQGGKditeeimsgggS 164
Cdd:PHA03247 2622 HAPDPPPPSPSPAANEPDPHPPPTVPP--PERPRDDPAP---GRVSRPRRARRLGRAAQASSPPQRPR-----------R 2685
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 165 RNPTPPIGRPASTPTPPQQLPSQVPEHSPVVYGT----VESAHLAASTPVTAAsdqkqeekPKPDPVFQSPSTVLRLVLS 240
Cdd:PHA03247 2686 RAARPTVGSLTSLADPPPPPPTPEPAPHALVSATplppGPAAARQASPALPAA--------PAPPAVPAGPATPGGPARP 2757
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 241 GEKKEQAGQMPETAAGEPTPEPPRTSSPTSLPPL--ARSSLPSPMSAALSSQPLfTAEDKCELPSSKEedAPPVPSPTSC 318
Cdd:PHA03247 2758 ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLseSRESLPSPWDPADPPAAV-LAPAAALPPAASP--AGPLPPPTSA 2834
|
330 340
....*....|....*....|....
gi 1907155796 319 TAASGPSLTDNSDICKKPC-SVAP 341
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPLGgSVAP 2858
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MIF4G |
pfam02854 |
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ... |
750-978 |
2.22e-63 |
|
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.
Pssm-ID: 397130 Cd Length: 203 Bit Score: 214.53 E-value: 2.22e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 750 FRKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLkvpmadkpgNTVNFR 829
Cdd:pfam02854 1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 830 KLLLNRCQKEFEKdkadddvfekkqkeleaasapeertrlHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCV 909
Cdd:pfam02854 72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907155796 910 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLCN 978
Cdd:pfam02854 125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
|
|
| MIF4G |
smart00543 |
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ... |
751-975 |
1.00e-50 |
|
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)
Pssm-ID: 214713 Cd Length: 200 Bit Score: 177.94 E-value: 1.00e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 751 RKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVtLKVPmadkpgntvNFRK 830
Cdd:smart00543 2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLN-AKNP---------DFGS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 831 LLLNRCQKEFEKDkadddvfekkqkeleaasapeertrlhdeLEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVV 910
Cdd:smart00543 72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907155796 911 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKT---SSRIRFMLQDVIDLR 975
Cdd:smart00543 123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELR 197
|
|
| W2_eIF4G1_like |
cd11559 |
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ... |
1399-1531 |
2.24e-48 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.
Pssm-ID: 211397 Cd Length: 134 Bit Score: 168.62 E-value: 2.24e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 1399 EELSQRLEKLIMEEKADDErIFDWVEANLDESQMSSPTFLRALMTAVCKAAIIADcSTFRVDTAVIKQRVPILLKYLDSD 1478
Cdd:cd11559 4 LRVQAELLKLLQEDPNPDE-LYKWIKENVSPELYASPGFVRALMTAVLKYAIEEK-SLPEKEKALLEKYAPLLQKYLDDD 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1907155796 1479 TEKELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPA 1531
Cdd:cd11559 82 EQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
|
|
| MA3 |
pfam02847 |
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ... |
1197-1309 |
9.87e-35 |
|
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.
Pssm-ID: 397128 Cd Length: 113 Bit Score: 128.93 E-value: 9.87e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 1197 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1276
Cdd:pfam02847 1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 1907155796 1277 TLELADDMAIDIPHIWLYLAELVTPMLKGGGIS 1309
Cdd:pfam02847 81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
|
|
| MA3 |
smart00544 |
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ... |
1197-1309 |
3.54e-32 |
|
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press
Pssm-ID: 214714 Cd Length: 113 Bit Score: 121.58 E-value: 3.54e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 1197 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1276
Cdd:smart00544 1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 1907155796 1277 TLELADDMAIDIPHIWLYLAELVTPMLKGGGIS 1309
Cdd:smart00544 81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
|
|
| eIF5C |
smart00515 |
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5; |
1469-1553 |
3.14e-28 |
|
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
Pssm-ID: 214705 Cd Length: 83 Bit Score: 109.30 E-value: 3.14e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 1469 PILLKYLDSDTEKELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPAEqaGKGVALKSVTAFFT 1548
Cdd:smart00515 1 GPLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVT 78
|
....*
gi 1907155796 1549 WLREA 1553
Cdd:smart00515 79 WLQEA 83
|
|
| W2 |
pfam02020 |
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ... |
1482-1558 |
1.25e-23 |
|
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.
Pssm-ID: 460415 Cd Length: 76 Bit Score: 95.67 E-value: 1.25e-23
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907155796 1482 ELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPAEQaGKGVALKSVTAFFTWLREAEEESE 1558
Cdd:pfam02020 1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAEK-GMKKVRKQAKPFVEWLEEAEEESD 76
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
161-325 |
5.83e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 51.00 E-value: 5.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 161 GGGSRNPTPPIGRPASTPTPPQQLPSQV-PEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVL 239
Cdd:PRK07003 368 PGGGVPARVAGAVPAPGARAAAAVGASAvPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDA 447
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 240 SGEKKEQAGQMPETAAGEPTPEPPRTSSPTS-----LPPLARSSlPSPMSAALSSQPLFTAEDKCELPSSKEEDAPPVP- 313
Cdd:PRK07003 448 PVPAKANARASADSRCDERDAQPPADSGSASapasdAPPDAAFE-PAPRAAAPSAATPAAVPDARAPAAASREDAPAAAa 526
|
170
....*....|..
gi 1907155796 314 SPTSCTAASGPS 325
Cdd:PRK07003 527 PPAPEARPPTPA 538
|
|
| Pneumo_att_G |
pfam05539 |
Pneumovirinae attachment membrane glycoprotein G; |
110-296 |
1.13e-04 |
|
Pneumovirinae attachment membrane glycoprotein G;
Pssm-ID: 114270 [Multi-domain] Cd Length: 408 Bit Score: 46.58 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 110 TPFYPSQpvyqsapiiVPTQQQPPPAKREKKTIRIRDPNQGgkditeeimSGGGSRNPTPPIGRPASTPTPPQQLPSQVP 189
Cdd:pfam05539 186 HPTYPSQ---------VTPQSQPATQGHQTATANQRLSSTE---------PVGTQGTTTSSNPEPQTEPPPSQRGPSGSP 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 190 EHSPvvygtvesahlaaSTP----VTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKKeqagqmPETAAGEPTPEPPRT 265
Cdd:pfam05539 248 QHPP-------------STTsqdqSTTGDGQEHTQRRKTPPATSNRRSPHSTATPPPTT------KRQETGRPTPRPTAT 308
|
170 180 190
....*....|....*....|....*....|.
gi 1907155796 266 SSPTSLPPlarSSLPSPMSAALSSQPLFTAE 296
Cdd:pfam05539 309 TQSGSSPP---HSSPPGVQANPTTQNLVDCK 336
|
|
| W2_eIF5C_like |
cd11560 |
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ... |
1510-1556 |
1.23e-04 |
|
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211398 [Multi-domain] Cd Length: 194 Bit Score: 44.90 E-value: 1.23e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1907155796 1510 LYDEEVISEDAFYKWesSKDPAEQAGKGVALKSVTAFFTWLREAEEE 1556
Cdd:cd11560 150 LYKADVLSEDAILKW--YKKGHSPKGKQVFLKQMEPFVEWLQEAEEE 194
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
5-341 |
7.72e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.54 E-value: 7.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 5 PQARSPFFQRpQIQPPRAAIPNSSPSIRPGVQTPTAVYQANQhimmvnhlpmpyPVTQGHQYCIPqyRHSGPPYVGPPQQ 84
Cdd:PHA03247 2557 PAAPPAAPDR-SVPPPRPAPRPSEPAVTSRARRPDAPPQSAR------------PRAPVDDRGDP--RGPAPPSPLPPDT 2621
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 85 YPVQPPGPGPFYPGPGPGDFANAYGTPfyPSQPVYQSAPiivPTQQQPPPAKREKKTIRIRDPNQGGKditeeimsgggS 164
Cdd:PHA03247 2622 HAPDPPPPSPSPAANEPDPHPPPTVPP--PERPRDDPAP---GRVSRPRRARRLGRAAQASSPPQRPR-----------R 2685
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 165 RNPTPPIGRPASTPTPPQQLPSQVPEHSPVVYGT----VESAHLAASTPVTAAsdqkqeekPKPDPVFQSPSTVLRLVLS 240
Cdd:PHA03247 2686 RAARPTVGSLTSLADPPPPPPTPEPAPHALVSATplppGPAAARQASPALPAA--------PAPPAVPAGPATPGGPARP 2757
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 241 GEKKEQAGQMPETAAGEPTPEPPRTSSPTSLPPL--ARSSLPSPMSAALSSQPLfTAEDKCELPSSKEedAPPVPSPTSC 318
Cdd:PHA03247 2758 ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLseSRESLPSPWDPADPPAAV-LAPAAALPPAASP--AGPLPPPTSA 2834
|
330 340
....*....|....*....|....
gi 1907155796 319 TAASGPSLTDNSDICKKPC-SVAP 341
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPLGgSVAP 2858
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
13-351 |
1.69e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 43.22 E-value: 1.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 13 QRPQIQPPRaaIPNSSPSIRPGVQTPTAVYQANQhimmvnhlPMPYPVTQGHQYCIPQYRHSGPPYVGPPQQYPVqppgp 92
Cdd:pfam03154 233 QTPTLHPQR--LPSPHPPLQPMTQPPPPSQVSPQ--------PLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQP----- 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 93 gpfypGPGPGDFANAYGTPF-YPSQPVY-QSAPIIVPTQQQPPPAKREKKTIRIRDPnqggkditeeimsgggsrNPTPP 170
Cdd:pfam03154 298 -----FPLTPQSSQSQVPPGpSPAAPGQsQQRIHTPPSQSQLQSQQPPREQPLPPAP------------------LSMPH 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 171 IGRPASTPTPPQQLPsQVPEHSPvvygtvesaHLAASTPVTAASDQkqeekpKPDPVFQSPSTVLRLVLSGEKKEQAGQM 250
Cdd:pfam03154 355 IKPPPTTPIPQLPNP-QSHKHPP---------HLSGPSPFQMNSNL------PPPPALKPLSSLSTHHPPSAHPPPLQLM 418
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 251 PETAAGEPTP-EPPRTSSPTSLPPLARSSLPSPMSAALSSQPLFTAEDKceLPSSKEEDAPPVPSPTScTAASGPSLtdn 329
Cdd:pfam03154 419 PQSQQLPPPPaQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPF--VPGGPPPITPPSGPPTS-TSSAMPGI--- 492
|
330 340
....*....|....*....|..
gi 1907155796 330 sdicKKPCSVAPHDSQLISSTI 351
Cdd:pfam03154 493 ----QPPSSASVSSSGPVPAAV 510
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MIF4G |
pfam02854 |
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ... |
750-978 |
2.22e-63 |
|
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.
Pssm-ID: 397130 Cd Length: 203 Bit Score: 214.53 E-value: 2.22e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 750 FRKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLkvpmadkpgNTVNFR 829
Cdd:pfam02854 1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 830 KLLLNRCQKEFEKdkadddvfekkqkeleaasapeertrlHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCV 909
Cdd:pfam02854 72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907155796 910 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLCN 978
Cdd:pfam02854 125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
|
|
| MIF4G |
smart00543 |
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ... |
751-975 |
1.00e-50 |
|
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)
Pssm-ID: 214713 Cd Length: 200 Bit Score: 177.94 E-value: 1.00e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 751 RKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVtLKVPmadkpgntvNFRK 830
Cdd:smart00543 2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLN-AKNP---------DFGS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 831 LLLNRCQKEFEKDkadddvfekkqkeleaasapeertrlhdeLEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVV 910
Cdd:smart00543 72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907155796 911 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKT---SSRIRFMLQDVIDLR 975
Cdd:smart00543 123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELR 197
|
|
| W2_eIF4G1_like |
cd11559 |
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ... |
1399-1531 |
2.24e-48 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.
Pssm-ID: 211397 Cd Length: 134 Bit Score: 168.62 E-value: 2.24e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 1399 EELSQRLEKLIMEEKADDErIFDWVEANLDESQMSSPTFLRALMTAVCKAAIIADcSTFRVDTAVIKQRVPILLKYLDSD 1478
Cdd:cd11559 4 LRVQAELLKLLQEDPNPDE-LYKWIKENVSPELYASPGFVRALMTAVLKYAIEEK-SLPEKEKALLEKYAPLLQKYLDDD 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1907155796 1479 TEKELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPA 1531
Cdd:cd11559 82 EQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
|
|
| MA3 |
pfam02847 |
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ... |
1197-1309 |
9.87e-35 |
|
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.
Pssm-ID: 397128 Cd Length: 113 Bit Score: 128.93 E-value: 9.87e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 1197 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1276
Cdd:pfam02847 1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 1907155796 1277 TLELADDMAIDIPHIWLYLAELVTPMLKGGGIS 1309
Cdd:pfam02847 81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
|
|
| MA3 |
smart00544 |
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ... |
1197-1309 |
3.54e-32 |
|
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press
Pssm-ID: 214714 Cd Length: 113 Bit Score: 121.58 E-value: 3.54e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 1197 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1276
Cdd:smart00544 1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 1907155796 1277 TLELADDMAIDIPHIWLYLAELVTPMLKGGGIS 1309
Cdd:smart00544 81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
|
|
| eIF5C |
smart00515 |
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5; |
1469-1553 |
3.14e-28 |
|
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
Pssm-ID: 214705 Cd Length: 83 Bit Score: 109.30 E-value: 3.14e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 1469 PILLKYLDSDTEKELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPAEqaGKGVALKSVTAFFT 1548
Cdd:smart00515 1 GPLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVT 78
|
....*
gi 1907155796 1549 WLREA 1553
Cdd:smart00515 79 WLQEA 83
|
|
| W2 |
pfam02020 |
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ... |
1482-1558 |
1.25e-23 |
|
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.
Pssm-ID: 460415 Cd Length: 76 Bit Score: 95.67 E-value: 1.25e-23
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907155796 1482 ELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPAEQaGKGVALKSVTAFFTWLREAEEESE 1558
Cdd:pfam02020 1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAEK-GMKKVRKQAKPFVEWLEEAEEESD 76
|
|
| W2 |
cd11473 |
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ... |
1399-1525 |
2.11e-18 |
|
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211395 Cd Length: 135 Bit Score: 82.91 E-value: 2.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 1399 EELSQRLEKLIMEEKADDERIFDWVEANLDESQMSSPTFLRALMTAVCKAAIIADCSTF---RVDTAVIKQRVPILLKYL 1475
Cdd:cd11473 4 KKLRDSLLKELEEDKSSDVESVKAAKSKLDLDPISLEEVVKVLLTAVVNAVESADSISLtqkEQLVLVLKKYGPVLRELL 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1907155796 1476 DSDTEKELQALYALQA--SIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWE 1525
Cdd:cd11473 84 KLIKKDQLYLLLKIEKlcLQLKLSELISLLEKILDLLYDADVLSEEAILSWF 135
|
|
| W2_eIF2B_epsilon |
cd11558 |
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a ... |
1439-1558 |
7.18e-15 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a heteropentameric complex which functions as a guanine nucleotide exchange factor in the recycling of eIF-2 during the initiation of translation in eukaryotes. The epsilon and gamma subunits are sequence similar and both are essential in yeast. Epsilon appears to be the catalytically active subunit, with gamma enhancing its activity. The C-terminal domain of the eIF2B epsilon subunit contains bipartite motifs rich in acidic and aromatic residues, which are responsible for the interaction with eIF2. The structure of the domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211396 Cd Length: 169 Bit Score: 73.83 E-value: 7.18e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 1439 RALMTAVCK-AAIIADCSTFRVDTA---VIKQRVPILLKYLDSDTEkELQALYALQASIVKLDQPANLLRMFFDCLYDEE 1514
Cdd:cd11558 47 RAVVKALLElILEVSSTSTAELLEAlkkLLSKWGPLLENYVKSQDD-QVELLLALEEFCLESEEGGPLFAKLLHALYDLD 125
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1907155796 1515 VISEDAFYKWESSKDPAEQAGKGVALKSVTAFFTWLREAEEESE 1558
Cdd:cd11558 126 ILEEEAILEWWEEPDAGADEEMKKVRELVKKFIEWLEEAEEESD 169
|
|
| W2_eIF5 |
cd11561 |
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ... |
1411-1558 |
1.95e-08 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211399 Cd Length: 157 Bit Score: 54.93 E-value: 1.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 1411 EEKADD--ERIFDWVEANLDESQMS-------SPTFLRALMTAVCkaAIIADCSTFRVDTAVIKQRVPILLKYLDSDtek 1481
Cdd:cd11561 1 EEEEDErvDELGEFLKKNKDESGLSelkeilkEAERLDVVKDKAV--LVLAEVLFDENIVKEIKKRKALLLKLVTDE--- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 1482 elQALYALQASIVKL--DQPANLLRMF---FDCLYDEEVISEDAFYKWeSSKDPAEQAGKGVA---LKSVTAFFTWLREA 1553
Cdd:cd11561 76 --KAQKALLGGIERFcgKHSPELLKKVpliLKALYDNDILEEEVILKW-YEKVSKKYVSKEKSkkvRKAAEPFVEWLEEA 152
|
....*
gi 1907155796 1554 EEESE 1558
Cdd:cd11561 153 EEEEE 157
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
161-325 |
5.83e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 51.00 E-value: 5.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 161 GGGSRNPTPPIGRPASTPTPPQQLPSQV-PEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVL 239
Cdd:PRK07003 368 PGGGVPARVAGAVPAPGARAAAAVGASAvPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDA 447
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 240 SGEKKEQAGQMPETAAGEPTPEPPRTSSPTS-----LPPLARSSlPSPMSAALSSQPLFTAEDKCELPSSKEEDAPPVP- 313
Cdd:PRK07003 448 PVPAKANARASADSRCDERDAQPPADSGSASapasdAPPDAAFE-PAPRAAAPSAATPAAVPDARAPAAASREDAPAAAa 526
|
170
....*....|..
gi 1907155796 314 SPTSCTAASGPS 325
Cdd:PRK07003 527 PPAPEARPPTPA 538
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
161-331 |
1.00e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 47.18 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 161 GGGSRNPTPPIGRPASTPTPPQQLPSQV-PEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRlvl 239
Cdd:PRK12323 368 SGGGAGPATAAAAPVAQPAPAAAAPAAAaPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP--- 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 240 SGEKKEQAGQMPETAAGEPTPEPPRTSSPTSLPPLARSSLPSPMSAALSSQPLFTAEDKCELPSSKEEDAPPVPSPTSCT 319
Cdd:PRK12323 445 GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAE 524
|
170
....*....|..
gi 1907155796 320 AASGPSLTDNSD 331
Cdd:PRK12323 525 SIPDPATADPDD 536
|
|
| Pneumo_att_G |
pfam05539 |
Pneumovirinae attachment membrane glycoprotein G; |
110-296 |
1.13e-04 |
|
Pneumovirinae attachment membrane glycoprotein G;
Pssm-ID: 114270 [Multi-domain] Cd Length: 408 Bit Score: 46.58 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 110 TPFYPSQpvyqsapiiVPTQQQPPPAKREKKTIRIRDPNQGgkditeeimSGGGSRNPTPPIGRPASTPTPPQQLPSQVP 189
Cdd:pfam05539 186 HPTYPSQ---------VTPQSQPATQGHQTATANQRLSSTE---------PVGTQGTTTSSNPEPQTEPPPSQRGPSGSP 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 190 EHSPvvygtvesahlaaSTP----VTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKKeqagqmPETAAGEPTPEPPRT 265
Cdd:pfam05539 248 QHPP-------------STTsqdqSTTGDGQEHTQRRKTPPATSNRRSPHSTATPPPTT------KRQETGRPTPRPTAT 308
|
170 180 190
....*....|....*....|....*....|.
gi 1907155796 266 SSPTSLPPlarSSLPSPMSAALSSQPLFTAE 296
Cdd:pfam05539 309 TQSGSSPP---HSSPPGVQANPTTQNLVDCK 336
|
|
| W2_eIF5C_like |
cd11560 |
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ... |
1510-1556 |
1.23e-04 |
|
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211398 [Multi-domain] Cd Length: 194 Bit Score: 44.90 E-value: 1.23e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1907155796 1510 LYDEEVISEDAFYKWesSKDPAEQAGKGVALKSVTAFFTWLREAEEE 1556
Cdd:cd11560 150 LYKADVLSEDAILKW--YKKGHSPKGKQVFLKQMEPFVEWLQEAEEE 194
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
10-315 |
1.68e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 46.62 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 10 PFFQRPQIqpPRAAIPNSSPSIR----PGVQTPTAVYQanqhimmvnhlPMPYPVTQGHQYCIPQYRHSGP---PYVGPP 82
Cdd:PRK10263 339 PVTQTPPV--ASVDVPPAQPTVAwqpvPGPQTGEPVIA-----------PAPEGYPQQSQYAQPAVQYNEPlqqPVQPQQ 405
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 83 QQYPVQPPGPgpfypgpgpgdfanaygtpfyPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEimsgg 162
Cdd:PRK10263 406 PYYAPAAEQP---------------------AQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQ----- 459
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 163 GSRNPTPPIGRPAstPTPPQQLPSQVPEHSPVVYGTVESAHLAASTPVTAASDQKQEEK------------PKPDPVfqs 230
Cdd:PRK10263 460 STYQTEQTYQQPA--AQEPLYQQPQPVEQQPVVEPEPVVEETKPARPPLYYFEEVEEKRarereqlaawyqPIPEPV--- 534
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 231 pstvlrlvlsgekKEQAGQMPETAAGEPTPEPPRTSSPTSLPPLA--RSSLPSPMSAALSSQPLFT-AEDKCELPSSKEE 307
Cdd:PRK10263 535 -------------KEPEPIKSSLKAPSVAAVPPVEAAAAVSPLASgvKKATLATGAAATVAAPVFSlANSGGPRPQVKEG 601
|
....*...
gi 1907155796 308 DAPPVPSP 315
Cdd:PRK10263 602 IGPQLPRP 609
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
110-331 |
2.72e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.08 E-value: 2.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 110 TPFYPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQ----------GGKDITEEIMSGGGSRNPTPPIGRPASTPT 179
Cdd:PHA03247 2762 TTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPwdpadppaavLAPAAALPPAASPAGPLPPPTSAQPTAPPP 2841
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 180 PPQQLPSQVPEHSPVVYG-TVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKKEQAGQMPETAAGEP 258
Cdd:PHA03247 2842 PPGPPPPSLPLGGSVAPGgDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQP 2921
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 259 TPEPP-RTSSPTSLPPLARSSLPSPMSAALSSQPLFTAED---------KCELPSSK-EEDAPPVPSPtsctAASGPSLT 327
Cdd:PHA03247 2922 QPPPPpQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQpwlgalvpgRVAVPRFRvPQPAPSREAP----ASSTPPLT 2997
|
....
gi 1907155796 328 DNSD 331
Cdd:PHA03247 2998 GHSL 3001
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
173-328 |
5.15e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 44.78 E-value: 5.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 173 RPASTPTPPQQLPSQvpEHSPVVygTVESAHLAASTPV---TAASDQKQEEKPKPDPVFQSPS------TVLRLVLSGEK 243
Cdd:PHA03307 23 RPPATPGDAADDLLS--GSQGQL--VSDSAELAAVTVVagaAACDRFEPPTGPPPGPGTEAPAnesrstPTWSLSTLAPA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 244 KEQAGQMPETAAGEPTPEPPRTSSPTSLPPLARSSLPSPMSAALSSQPLFTAEDKC-ELPSSKEEDAPPVPSPTSCTAAS 322
Cdd:PHA03307 99 SPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAaGASPAAVASDAASSRQAALPLSS 178
|
....*.
gi 1907155796 323 GPSLTD 328
Cdd:PHA03307 179 PEETAR 184
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
5-341 |
7.72e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.54 E-value: 7.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 5 PQARSPFFQRpQIQPPRAAIPNSSPSIRPGVQTPTAVYQANQhimmvnhlpmpyPVTQGHQYCIPqyRHSGPPYVGPPQQ 84
Cdd:PHA03247 2557 PAAPPAAPDR-SVPPPRPAPRPSEPAVTSRARRPDAPPQSAR------------PRAPVDDRGDP--RGPAPPSPLPPDT 2621
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 85 YPVQPPGPGPFYPGPGPGDFANAYGTPfyPSQPVYQSAPiivPTQQQPPPAKREKKTIRIRDPNQGGKditeeimsgggS 164
Cdd:PHA03247 2622 HAPDPPPPSPSPAANEPDPHPPPTVPP--PERPRDDPAP---GRVSRPRRARRLGRAAQASSPPQRPR-----------R 2685
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 165 RNPTPPIGRPASTPTPPQQLPSQVPEHSPVVYGT----VESAHLAASTPVTAAsdqkqeekPKPDPVFQSPSTVLRLVLS 240
Cdd:PHA03247 2686 RAARPTVGSLTSLADPPPPPPTPEPAPHALVSATplppGPAAARQASPALPAA--------PAPPAVPAGPATPGGPARP 2757
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 241 GEKKEQAGQMPETAAGEPTPEPPRTSSPTSLPPL--ARSSLPSPMSAALSSQPLfTAEDKCELPSSKEedAPPVPSPTSC 318
Cdd:PHA03247 2758 ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLseSRESLPSPWDPADPPAAV-LAPAAALPPAASP--AGPLPPPTSA 2834
|
330 340
....*....|....*....|....
gi 1907155796 319 TAASGPSLTDNSDICKKPC-SVAP 341
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPLGgSVAP 2858
|
|
| PRK11901 |
PRK11901 |
hypothetical protein; Reviewed |
114-241 |
9.43e-04 |
|
hypothetical protein; Reviewed
Pssm-ID: 237015 [Multi-domain] Cd Length: 327 Bit Score: 43.13 E-value: 9.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 114 PSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDP---------NQGGKDITEEIMSGGGSRNPTPPIGRPASTPTPPQQL 184
Cdd:PRK11901 113 TAPPQDISAPPISPTPTQAAPPQTPNGQQRIELPgnisdalsqQQGQVNAASQNAQGNTSTLPTAPATVAPSKGAKVPAT 192
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 185 PSQVPEHSPVVYGT--VESAHLAASTPVTAASDQKQEEKPKPDPVFQS-PSTVLRLVLSG 241
Cdd:PRK11901 193 AETHPTPPQKPATKkpAVNHHKTATVAVPPATSGKPKSGAASARALSSaPASHYTLQLSS 252
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
160-325 |
1.13e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 43.82 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 160 SGGGSRNPTPPIGRPASTPTPPQQLPSQVPehSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVL 239
Cdd:PRK07764 601 PAPASSGPPEEAARPAAPAAPAAPAAPAPA--GAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAP 678
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 240 SGEKKEQAGQMPETAAGEPTPEP----------PRTSSPTSLPPLARSSLPSPMSAALSSQPLFTAEDKCELPSSKEEDA 309
Cdd:PRK07764 679 AAPPPAPAPAAPAAPAGAAPAQPapapaatppaGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQP 758
|
170
....*....|....*.
gi 1907155796 310 PPVPSPTSCTAASGPS 325
Cdd:PRK07764 759 PPPPAPAPAAAPAAAP 774
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
13-351 |
1.69e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 43.22 E-value: 1.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 13 QRPQIQPPRaaIPNSSPSIRPGVQTPTAVYQANQhimmvnhlPMPYPVTQGHQYCIPQYRHSGPPYVGPPQQYPVqppgp 92
Cdd:pfam03154 233 QTPTLHPQR--LPSPHPPLQPMTQPPPPSQVSPQ--------PLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQP----- 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 93 gpfypGPGPGDFANAYGTPF-YPSQPVY-QSAPIIVPTQQQPPPAKREKKTIRIRDPnqggkditeeimsgggsrNPTPP 170
Cdd:pfam03154 298 -----FPLTPQSSQSQVPPGpSPAAPGQsQQRIHTPPSQSQLQSQQPPREQPLPPAP------------------LSMPH 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 171 IGRPASTPTPPQQLPsQVPEHSPvvygtvesaHLAASTPVTAASDQkqeekpKPDPVFQSPSTVLRLVLSGEKKEQAGQM 250
Cdd:pfam03154 355 IKPPPTTPIPQLPNP-QSHKHPP---------HLSGPSPFQMNSNL------PPPPALKPLSSLSTHHPPSAHPPPLQLM 418
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 251 PETAAGEPTP-EPPRTSSPTSLPPLARSSLPSPMSAALSSQPLFTAEDKceLPSSKEEDAPPVPSPTScTAASGPSLtdn 329
Cdd:pfam03154 419 PQSQQLPPPPaQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPF--VPGGPPPITPPSGPPTS-TSSAMPGI--- 492
|
330 340
....*....|....*....|..
gi 1907155796 330 sdicKKPCSVAPHDSQLISSTI 351
Cdd:pfam03154 493 ----QPPSSASVSSSGPVPAAV 510
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
35-321 |
2.37e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 42.75 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 35 VQTPTAVYQANQHIMMVNHLPMPYPVTQGHQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFaNAYGTPfYP 114
Cdd:PHA03378 574 IQPLTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPITF-NVLVFP-TP 651
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 115 SQPVYQSAPIIVPTQQQPPPAKREkktirirdPNQGGKDITEEIMSGGGSRNP---TPPIGRPASTPTPPQQLPSQVPEH 191
Cdd:PHA03378 652 HQPPQVEITPYKPTWTQIGHIPYQ--------PSPTGANTMLPIQWAPGTMQPpprAPTPMRPPAAPPGRAQRPAAATGR 723
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 192 SPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKKEQAGQMPETAA----GEPTPEPPRTSS 267
Cdd:PHA03378 724 ARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQqrprGAPTPQPPPQAG 803
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907155796 268 PTSLPPLARSSLPSPMSAALSSQPLFTAEDKCELPSSK-----EEDAP--PVPSPTSCTAA 321
Cdd:PHA03378 804 PTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKkpaalERQAAagPTPSPGSGTSD 864
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
185-326 |
2.57e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 42.76 E-value: 2.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 185 PSQVPEHSPVVYGTVESAHLAASTPVTAASdqkQEEKPKPDPVFQSPStvlrlVLSGEKKEQAGQMP-ETAAGEPTPEPP 263
Cdd:PRK10263 301 QPEYDEYDPLLNGAPITEPVAVAAAATTAT---QSWAAPVEPVTQTPP-----VASVDVPPAQPTVAwQPVPGPQTGEPV 372
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907155796 264 RTSSPTSLPPLARSSLPSPMSAALSSQPlFTAEDKCELPSSKEEDAPPVPSPTSCTAASGPSL 326
Cdd:PRK10263 373 IAPAPEGYPQQSQYAQPAVQYNEPLQQP-VQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYY 434
|
|
| DUF4045 |
pfam13254 |
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ... |
127-310 |
3.31e-03 |
|
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.
Pssm-ID: 433066 [Multi-domain] Cd Length: 415 Bit Score: 41.69 E-value: 3.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 127 PTQQQPPPAKREKKTIRirdPNQGGKDiteeiMSGGGSRNPTPPIGRPASTPTPPQQLPSQVPEHSPVVYGTVESAHLAA 206
Cdd:pfam13254 170 PSQPAQPAWMKELNKIR---QSRASVD-----LGRPNSFKEVTPVGLMRSPAPGGHSKSPSVSGISADSSPTKEEPSEEA 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 207 STPVTaasdqKQEEKPKPDPVFQSPSTVLRLvlsgEKKEQAGQMPETAAGEPT--PEPPRTSSPTSLPPLARSSLPSPMS 284
Cdd:pfam13254 242 DTLST-----DKEQSPAPTSASEPPPKTKEL----PKDSEEPAAPSKSAEASTekKEPDTESSPETSSEKSAPSLLSPVS 312
|
170 180
....*....|....*....|....*.
gi 1907155796 285 AALSSQPLFTAEDKCELPSSKEEDAP 310
Cdd:pfam13254 313 KASIDKPLSSPDRDPLSPKPKPQSPP 338
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
19-312 |
9.21e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.08 E-value: 9.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 19 PPRAAIPNSSPSIRPGVQTPTAVYQANQHIMMVNHLPMPYPVT---QGHQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPF 95
Cdd:PHA03247 2766 PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPaavLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP 2845
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 96 YPGPGPGDFANAYGTPFYPSQPVYQSAPiiVPTQQQPPPAKREKKTIRIRDPNqggkdiTEEIMSGGGSRNPTPPIGRPA 175
Cdd:PHA03247 2846 PPPSLPLGGSVAPGGDVRRRPPSRSPAA--KPAAPARPPVRRLARPAVSRSTE------SFALPPDQPERPPQPQAPPPP 2917
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 176 STPTPPQQLPSQVPEHSPvvygTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPstvlrlvlsgekkeqaGQMPETAA 255
Cdd:PHA03247 2918 QPQPQPPPPPQPQPPPPP----PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVP----------------GRVAVPRF 2977
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1907155796 256 GEPTPEPPRTSSPTSLPPLARSSLPSPMSAALSsqplftaedkceLPSSKEEDAPPV 312
Cdd:PHA03247 2978 RVPQPAPSREAPASSTPPLTGHSLSRVSSWASS------------LALHEETDPPPV 3022
|
|
| DUF4045 |
pfam13254 |
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ... |
173-341 |
9.62e-03 |
|
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.
Pssm-ID: 433066 [Multi-domain] Cd Length: 415 Bit Score: 40.15 E-value: 9.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 173 RPASTPTPPQQlPSQVPEHSPVvYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKKEQAGQMPE 252
Cdd:pfam13254 165 KPKAQPSQPAQ-PAWMKELNKI-RQSRASVDLGRPNSFKEVTPVGLMRSPAPGGHSKSPSVSGISADSSPTKEEPSEEAD 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155796 253 TAAGEPTPEPPRTSSPTSLPPLARSSLPSPMSAALSSQPLFTAEDKCELPSSK-----EEDAPPVPSPTSCTAASGPSLT 327
Cdd:pfam13254 243 TLSTDKEQSPAPTSASEPPPKTKELPKDSEEPAAPSKSAEASTEKKEPDTESSpetssEKSAPSLLSPVSKASIDKPLSS 322
|
170
....*....|....*
gi 1907155796 328 DNSD-ICKKPCSVAP 341
Cdd:pfam13254 323 PDRDpLSPKPKPQSP 337
|
|
| |
