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Conserved domains on  [gi|1907155528|ref|XP_036019897|]
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EF-hand calcium-binding domain-containing protein 7 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00184 super family cl33172
calmodulin; Provisional
 45-168 6.44e-12

calmodulin; Provisional


The actual alignment was detected with superfamily member PTZ00184:

Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 63.63  E-value: 6.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155528  45 TIFKSSLENIISKDQLYLALQHAGRNPS----QKTINKYWTPQTAKLNFDDFCIILS-KEKPT-SKAELLKSFKKLDVND 118
Cdd:PTZ00184   18 SLFDKDGDGTITTKELGTVMRSLGQNPTeaelQDMINEVDADGNGTIDFPEFLTLMArKMKDTdSEEEIKEAFKVFDRDG 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907155528 119 DGAILHSDLQKYLTKRGEKMTQEEVNAVINLADINANGKFDYVKFCKLYM 168
Cdd:PTZ00184   98 NGFISAAELRHVMTNLGEKLTDEEVDEMIREADVDGDGQINYEEFVKMMM 147
EFh super family cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 407-467 5.08e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


The actual alignment was detected with superfamily member cd00051:

Pssm-ID: 415501 [Multi-domain]  Cd Length: 63  Bit Score: 35.60  E-value: 5.08e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907155528 407 LSEIFEVIDLDGNGLISLEEYNFFeLRTSGEKCDEDAW-AVCREnFDTKKN-ELTRQGFMDLH 467
Cdd:cd00051     2 LREAFRLFDKDGDGTISADELKAA-LKSLGEGLSEEEIdEMIRE-VDKDGDgKIDFEEFLELM 62
 
Name Accession Description Interval E-value
PTZ00184 PTZ00184
calmodulin; Provisional
 45-168 6.44e-12

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 63.63  E-value: 6.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155528  45 TIFKSSLENIISKDQLYLALQHAGRNPS----QKTINKYWTPQTAKLNFDDFCIILS-KEKPT-SKAELLKSFKKLDVND 118
Cdd:PTZ00184   18 SLFDKDGDGTITTKELGTVMRSLGQNPTeaelQDMINEVDADGNGTIDFPEFLTLMArKMKDTdSEEEIKEAFKVFDRDG 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907155528 119 DGAILHSDLQKYLTKRGEKMTQEEVNAVINLADINANGKFDYVKFCKLYM 168
Cdd:PTZ00184   98 NGFISAAELRHVMTNLGEKLTDEEVDEMIREADVDGDGQINYEEFVKMMM 147
EF-hand_7 pfam13499
EF-hand domain pair;
104-168 1.58e-11

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 59.96  E-value: 1.58e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907155528 104 KAELLKSFKKLDVNDDGAILHSDLQKYLTK--RGEKMTQEEVNAVINLADINANGKFDYVKFCKLYM 168
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKleEGEPLSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 106-166 6.36e-10

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 55.25  E-value: 6.36e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907155528 106 ELLKSFKKLDVNDDGAILHSDLQKYLTKRGEKMTQEEVNAVINLADINANGKFDYVKFCKL 166
Cdd:cd00051     1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLEL 61
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
81-166 1.62e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 39.00  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155528  81 TPQTAKLNFDDFC-IILSKEKPTSKAELLKSFKKLDVNDDGAILHSDLQKYLTKRGekMTQEEVNAVINLADINANGKFD 159
Cdd:COG5126    44 TDGDGRISREEFVaGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALG--VSEEEADELFARLDTDGDGKIS 121


                  ....*..
gi 1907155528 160 YVKFCKL 166
Cdd:COG5126   122 FEEFVAA 128
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 407-467 5.08e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 35.60  E-value: 5.08e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907155528 407 LSEIFEVIDLDGNGLISLEEYNFFeLRTSGEKCDEDAW-AVCREnFDTKKN-ELTRQGFMDLH 467
Cdd:cd00051     2 LREAFRLFDKDGDGTISADELKAA-LKSLGEGLSEEEIdEMIRE-VDKDGDgKIDFEEFLELM 62
 
Name Accession Description Interval E-value
PTZ00184 PTZ00184
calmodulin; Provisional
 45-168 6.44e-12

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 63.63  E-value: 6.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155528  45 TIFKSSLENIISKDQLYLALQHAGRNPS----QKTINKYWTPQTAKLNFDDFCIILS-KEKPT-SKAELLKSFKKLDVND 118
Cdd:PTZ00184   18 SLFDKDGDGTITTKELGTVMRSLGQNPTeaelQDMINEVDADGNGTIDFPEFLTLMArKMKDTdSEEEIKEAFKVFDRDG 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907155528 119 DGAILHSDLQKYLTKRGEKMTQEEVNAVINLADINANGKFDYVKFCKLYM 168
Cdd:PTZ00184   98 NGFISAAELRHVMTNLGEKLTDEEVDEMIREADVDGDGQINYEEFVKMMM 147
EF-hand_7 pfam13499
EF-hand domain pair;
104-168 1.58e-11

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 59.96  E-value: 1.58e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907155528 104 KAELLKSFKKLDVNDDGAILHSDLQKYLTK--RGEKMTQEEVNAVINLADINANGKFDYVKFCKLYM 168
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKleEGEPLSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 106-166 6.36e-10

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 55.25  E-value: 6.36e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907155528 106 ELLKSFKKLDVNDDGAILHSDLQKYLTKRGEKMTQEEVNAVINLADINANGKFDYVKFCKL 166
Cdd:cd00051     1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLEL 61
PTZ00183 PTZ00183
centrin; Provisional
 21-171 2.37e-09

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 56.62  E-value: 2.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155528  21 SPRTKKFPLTEQEVfyMNCRAAYlTIFKSSLENIISKDQLYLALQHAGRNPSQKTINKYW----TPQTAKLNFDDFCIIL 96
Cdd:PTZ00183    3 KRRSERPGLTEDQK--KEIREAF-DLFDTDGSGTIDPKELKVAMRSLGFEPKKEEIKQMIadvdKDGSGKIDFEEFLDIM 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907155528  97 SKE--KPTSKAELLKSFKKLDVNDDGAILHSDLQKYLTKRGEKMTQEEVNAVINLADINANGKFDYVKFCKLYMTTS 171
Cdd:PTZ00183   80 TKKlgERDPREEILKAFRLFDDDKTGKISLKNLKRVAKELGETITDEELQEMIDEADRNGDGEISEEEFYRIMKKTN 156
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
81-166 1.62e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 39.00  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155528  81 TPQTAKLNFDDFC-IILSKEKPTSKAELLKSFKKLDVNDDGAILHSDLQKYLTKRGekMTQEEVNAVINLADINANGKFD 159
Cdd:COG5126    44 TDGDGRISREEFVaGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALG--VSEEEADELFARLDTDGDGKIS 121


                  ....*..
gi 1907155528 160 YVKFCKL 166
Cdd:COG5126   122 FEEFVAA 128
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 407-467 5.08e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 35.60  E-value: 5.08e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907155528 407 LSEIFEVIDLDGNGLISLEEYNFFeLRTSGEKCDEDAW-AVCREnFDTKKN-ELTRQGFMDLH 467
Cdd:cd00051     2 LREAFRLFDKDGDGTISADELKAA-LKSLGEGLSEEEIdEMIRE-VDKDGDgKIDFEEFLELM 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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