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Conserved domains on  [gi|1907154400|ref|XP_036019629|]
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inversin isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
274-564 6.10e-53

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 187.08  E-value: 6.10e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  274 IVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLrtMLSLKSDID 353
Cdd:COG0666      2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVA--LLLLAAGAD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  354 INMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHW 433
Cdd:COG0666     80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  434 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 513
Cdd:COG0666    160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907154400  514 DFAAFPNqmENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAF 564
Cdd:COG0666    240 EAGADLN--AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-240 2.19e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.40  E-value: 2.19e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   19 HAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMK 98
Cdd:COG0666     58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   99 LLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKfmAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIP 178
Cdd:COG0666    138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE--AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907154400  179 DVEGKIPLHWAANHKDPSAVHtvrcILDAAptESLLNWQDYEGRTPLHFAVADGNLTVVDVL 240
Cdd:COG0666    216 DNDGKTALDLAAENGNLEIVK----LLLEA--GADLNAKDKDGLTALLLAAAAGAALIVKLL 271
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 617-890 1.02e-10

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 66.35  E-value: 1.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  617 LDTDPPRSHCSSSAPvlPCPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKPS 696
Cdd:PHA03307   176 LSSPEETARAPSSPP--AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPEN 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  697 ETPIEHcrgPSACVHP-RSWEGGNSSKNQGTSSVEKRRGETNGKHRRCEegPSSARQPLCTGSGRPAEKGEDSSPAVASA 775
Cdd:PHA03307   254 ECPLPR---PAPITLPtRIWEASGWNGPSSRPGPASSSSSPRERSPSPS--PSSPGSGPAPSSPRASSSSSSSRESSSSS 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  776 SQQDHP--------------RKPNKRQDRAARPRGASQKRRTHQLRDRCSPAGSSRPGSAKGEVACADQSSLHRHTPRsk 841
Cdd:PHA03307   329 TSSSSEssrgaavspgpspsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR-- 406

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907154400  842 vtqdkLIGGVSSGLPLSTEASRSGCKQLYEDI--CASPETGVAhGPPPGQC 890
Cdd:PHA03307   407 -----FPAGRPRPSPLDAGAASGAFYARYPLLtpSGEPWPGSP-PPPPGRV 451
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 911-936 4.27e-05

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


:

Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 41.37  E-value: 4.27e-05
                           10        20
                   ....*....|....*....|....*.
gi 1907154400  911 RKELFRRKNKAAAVIQRAWRSYQLRK 936
Cdd:cd23767      1 EEEELQRMNRAATLIQALWRGYKVRK 26
Ank_4 pfam13637
Ankyrin repeats (many copies);
221-279 4.34e-04

Ankyrin repeats (many copies);


:

Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 4.34e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907154400  221 GRTPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAAllgtFGRHAQIVHLLL 279
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAA----SNGNVEVLKLLL 54
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 557-583 5.55e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


:

Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 38.29  E-value: 5.55e-04
                           10        20
                   ....*....|....*....|....*..
gi 1907154400  557 AIQDIAAFKIQAVYKGYKVRKAFRDRK 583
Cdd:cd23767      6 QRMNRAATLIQALWRGYKVRKELKKKK 32
C11orf65 super family cl41231
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 ...
 918-964 6.67e-03

chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 (C11orf65) is an uncharacterized protein that may be associated with potential sensitivity to metformin in type 2 diabetes (diabetes mellitus) patients without cancer.


The actual alignment was detected with superfamily member cd21090:

Pssm-ID: 411042  Cd Length: 260  Bit Score: 39.61  E-value: 6.67e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907154400  918 KNKAAAVIQRAWRSY---QLRKHLSRLLHLKQLG-AREVLRCTQVCTALLL 964
Cdd:cd21090      4 REEAARIIQRAWRRHidvQVFRYYKDLINFRGQGdPRLMLKCINPKEAELL 54
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
274-564 6.10e-53

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 187.08  E-value: 6.10e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  274 IVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLrtMLSLKSDID 353
Cdd:COG0666      2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVA--LLLLAAGAD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  354 INMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHW 433
Cdd:COG0666     80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  434 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 513
Cdd:COG0666    160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907154400  514 DFAAFPNqmENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAF 564
Cdd:COG0666    240 EAGADLN--AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-240 2.19e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.40  E-value: 2.19e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   19 HAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMK 98
Cdd:COG0666     58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   99 LLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKfmAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIP 178
Cdd:COG0666    138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE--AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907154400  179 DVEGKIPLHWAANHKDPSAVHtvrcILDAAptESLLNWQDYEGRTPLHFAVADGNLTVVDVL 240
Cdd:COG0666    216 DNDGKTALDLAAENGNLEIVK----LLLEA--GADLNAKDKDGLTALLLAAAAGAALIVKLL 271
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 340-558 5.84e-23

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 102.82  E-value: 5.84e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  340 DVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVST-----VKLLLDNDAQVDATDVMKHTPLFRA--CEMGHRDVIQT 412
Cdd:PHA03100    49 DVVKILL--DNGADINSSTKNNSTPLHYLSNIKYNLTdvkeiVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEY 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  413 LIKGGARVDLVDQDGHSLLHWAALGGNAD--VCQILIENKINPNVQDYagrtplqcaayggyINCmavLMENNADPNIQD 490
Cdd:PHA03100   127 LLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINAKNR--------------VNY---LLSYGVPINIKD 189

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907154400  491 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEerYTPLDYALLGERHEVIQFMLEHGAlSIAAI 558
Cdd:PHA03100   190 VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG--DTPLHIAILNNNKEIFKLLLNNGP-SIKTI 254
Ank_2 pfam12796
Ankyrin repeats (3 copies);
398-490 3.71e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 91.72  E-value: 3.71e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  398 LFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEnKINPNVQDYaGRTPLQCAAYGGYINCMA 477
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1907154400  478 VLMENNADPNIQD 490
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 59-420 2.47e-20

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 96.67  E-value: 2.47e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   59 DRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKfma 138
Cdd:PHA02876   156 DELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID--- 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  139 pgevDTQDKNKQTALHWSAYYNNPEHAKLLIkHDSNIGIP--DVEGKIPLHWAAnhKDPSAVHTVRCILDAAPTeslLNW 216
Cdd:PHA02876   233 ----NRSNINKNDLSLLKAIRNEDLETSLLL-YDAGFSVNsiDDCKNTPLHHAS--QAPSLSRLVPKLLERGAD---VNA 302

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  217 QDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLFRTPLHWAAllgTFGRHAQIVHLLLERNkSGTIPSDSQGATP 296
Cdd:PHA02876   303 KNIKGETPLYLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQAS---TLDRNKDIVITLLELG-ANVNARDYCDKTP 378

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  297 LHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNddvlrTMLSLKSDID----INMSDKYGGTALHAAALSG 372
Cdd:PHA02876   379 IHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTN-----PYMSVKTLIDrganVNSKNKDLSTPLHYACKKN 453

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1907154400  373 -HVSTVKLLLDNDAQVDATDVMKHTPLFRAceMGHRDVIQTLIKGGARV 420
Cdd:PHA02876   454 cKLDVIEMLLDNGADVNAINIQNQYPLLIA--LEYHGIVNILLHYGAEL 500
Ank_2 pfam12796
Ankyrin repeats (3 copies);
85-179 1.00e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 82.09  E-value: 1.00e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   85 LHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGEVDtqdkNKQTALHWSAYYNNPEH 164
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD----NGRTALHYAARSGHLEI 76

                           90
                   ....*....|....*
gi 1907154400  165 AKLLIKHDSNIGIPD 179
Cdd:pfam12796   77 VKLLLEKGADINVKD 91
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 617-890 1.02e-10

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 66.35  E-value: 1.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  617 LDTDPPRSHCSSSAPvlPCPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKPS 696
Cdd:PHA03307   176 LSSPEETARAPSSPP--AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPEN 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  697 ETPIEHcrgPSACVHP-RSWEGGNSSKNQGTSSVEKRRGETNGKHRRCEegPSSARQPLCTGSGRPAEKGEDSSPAVASA 775
Cdd:PHA03307   254 ECPLPR---PAPITLPtRIWEASGWNGPSSRPGPASSSSSPRERSPSPS--PSSPGSGPAPSSPRASSSSSSSRESSSSS 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  776 SQQDHP--------------RKPNKRQDRAARPRGASQKRRTHQLRDRCSPAGSSRPGSAKGEVACADQSSLHRHTPRsk 841
Cdd:PHA03307   329 TSSSSEssrgaavspgpspsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR-- 406

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907154400  842 vtqdkLIGGVSSGLPLSTEASRSGCKQLYEDI--CASPETGVAhGPPPGQC 890
Cdd:PHA03307   407 -----FPAGRPRPSPLDAGAASGAFYARYPLLtpSGEPWPGSP-PPPPGRV 451
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 295-501 8.20e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 59.64  E-value: 8.20e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  295 TPLHYAAQSNFAETVKVFLQHPSVkddsDLE-----GRTSFMWAAGKGNDDVLRTMLSLKSDIdINM---SDKYGG-TAL 365
Cdd:cd22192     19 SPLLLAAKENDVQAIKKLLKCPSC----DLFqrgalGETALHVAALYDNLEAAVVLMEAAPEL-VNEpmtSDLYQGeTAL 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  366 HAAALSGHVSTVKLLLDNDAQV---DATDVM------------KHTPLFRACeMGHRDVIQTLIKGGArvDLVDQD--GH 428
Cdd:cd22192     94 HIAVVNQNLNLVRELIARGADVvspRATGTFfrpgpknliyygEHPLSFAAC-VGNEEIVRLLIEHGA--DIRAQDslGN 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  429 SLLHWAALGGNAD-VCQI--LI---ENKINP----NVQDYAGRTPLQCAAYGGYINCMAVLMENnadpniqdkegRTALH 498
Cdd:cd22192    171 TVLHILVLQPNKTfACQMydLIlsyDKEDDLqpldLVPNNQGLTPFKLAAKEGNIVMFQHLVQK-----------RRHIQ 239


                   ...
gi 1907154400  499 WSC 501
Cdd:cd22192    240 WTY 242
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 21-236 9.03e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 49.63  E-value: 9.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   21 AAVNGDKGALQRLIVGNSAlrDKEDR--FGRTPLMYCVLADRVDCADALLKAGAD-VNKTDHSR----RTALHLAAQKGN 93
Cdd:cd22192     24 AAKENDVQAIKKLLKCPSC--DLFQRgaLGETALHVAALYDNLEAAVVLMEAAPElVNEPMTSDlyqgETALHIAVVNQN 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   94 YRFMKLLLTRRAnwmqkdlEEMTPLHLSTR-HRSPKClalLLKFmapGEvdtqdknkqTALHWSAYYNNPEHAKLLIKHD 172
Cdd:cd22192    102 LNLVRELIARGA-------DVVSPRATGTFfRPGPKN---LIYY---GE---------HPLSFAACVGNEEIVRLLIEHG 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907154400  173 SNIGIPDVEGKIPLH---WAANHKdpSAVHTVRCIL------DAAPTESLLNwqdYEGRTPLHFAVADGNLTV 236
Cdd:cd22192    160 ADIRAQDSLGNTVLHilvLQPNKT--FACQMYDLILsydkedDLQPLDLVPN---NQGLTPFKLAAKEGNIVM 227
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 911-936 4.27e-05

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 41.37  E-value: 4.27e-05
                           10        20
                   ....*....|....*....|....*.
gi 1907154400  911 RKELFRRKNKAAAVIQRAWRSYQLRK 936
Cdd:cd23767      1 EEEELQRMNRAATLIQALWRGYKVRK 26
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 48-76 1.90e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 1.90e-04
                            10        20
                    ....*....|....*....|....*....
gi 1907154400    48 GRTPLMYCVLADRVDCADALLKAGADVNK 76
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 426-455 3.64e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 3.64e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 1907154400   426 DGHSLLHWAALGGNADVCQILIENKINPNV 455
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
221-279 4.34e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 4.34e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907154400  221 GRTPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAAllgtFGRHAQIVHLLL 279
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAA----SNGNVEVLKLLL 54
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 557-583 5.55e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 38.29  E-value: 5.55e-04
                           10        20
                   ....*....|....*....|....*..
gi 1907154400  557 AIQDIAAFKIQAVYKGYKVRKAFRDRK 583
Cdd:cd23767      6 QRMNRAATLIQALWRGYKVRKELKKKK 32
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 228-481 6.77e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.53  E-value: 6.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  228 AVADGNLTVV-DVLTSYESCNITSYDNLFRTPLHWAALLGtfgRHAQIVHLLLERNKSGTIpsdsqGATPLHyAAQSNFA 306
Cdd:TIGR00870   24 AAERGDLASVyRDLEEPKKLNINCPDRLGRSALFVAAIEN---ENLELTELLLNLSCRGAV-----GDTLLH-AISLEYV 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  307 ETVKVFLQHPsvkDDSDLEGRTSFMwaagkgnddvlrtmlslksDIDINMSDKYGG-TALHAAALSGHVSTVKLLLDNDA 385
Cdd:TIGR00870   95 DAVEAILLHL---LAAFRKSGPLEL-------------------ANDQYTSEFTPGiTALHLAAHRQNYEIVKLLLERGA 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  386 QVDA------------TDVMKHT--PL-FRACeMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALggNAD--------V 442
Cdd:TIGR00870  153 SVPAracgdffvksqgVDSFYHGesPLnAAAC-LGSPSIVALLSEDPADILTADSLGNTLLHLLVM--ENEfkaeyeelS 229

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907154400  443 CQI-------------LIENKINPNvqdYAGRTPLQCAAYGGYINCMAVLME 481
Cdd:TIGR00870  230 CQMynfalslldklrdSKELEVILN---HQGLTPLKLAAKEGRIVLFRLKLA 278
C11orf65 cd21090
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 ...
 918-964 6.67e-03

chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 (C11orf65) is an uncharacterized protein that may be associated with potential sensitivity to metformin in type 2 diabetes (diabetes mellitus) patients without cancer.


Pssm-ID: 411042  Cd Length: 260  Bit Score: 39.61  E-value: 6.67e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907154400  918 KNKAAAVIQRAWRSY---QLRKHLSRLLHLKQLG-AREVLRCTQVCTALLL 964
Cdd:cd21090      4 REEAARIIQRAWRRHidvQVFRYYKDLINFRGQGdPRLMLKCINPKEAELL 54
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
274-564 6.10e-53

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 187.08  E-value: 6.10e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  274 IVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLrtMLSLKSDID 353
Cdd:COG0666      2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVA--LLLLAAGAD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  354 INMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHW 433
Cdd:COG0666     80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  434 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 513
Cdd:COG0666    160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907154400  514 DFAAFPNqmENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAF 564
Cdd:COG0666    240 EAGADLN--AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
310-598 7.25e-50

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 178.61  E-value: 7.25e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  310 KVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDA 389
Cdd:COG0666      3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  390 TDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAY 469
Cdd:COG0666     83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  470 GGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMenNEERYTPLDYALLGERHEVIQFMLE 549
Cdd:COG0666    163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK--DNDGKTALDLAAENGNLEIVKLLLE 240

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1907154400  550 HGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAA 598
Cdd:COG0666    241 AGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
204-497 1.92e-45

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 165.90  E-value: 1.92e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  204 ILDAAPTESLLNWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLFRTPLHWAALlgtfgRHAQIVHLLLERNK 283
Cdd:COG0666      3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAAL-----AGDLLVALLLLAAG 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  284 SGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRtMLsLKSDIDINMSDKYGGT 363
Cdd:COG0666     78 ADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK-LL-LEAGADVNAQDNDGNT 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  364 ALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVC 443
Cdd:COG0666    156 PLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907154400  444 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTAL 497
Cdd:COG0666    236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-240 2.19e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.40  E-value: 2.19e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   19 HAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMK 98
Cdd:COG0666     58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   99 LLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKfmAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIP 178
Cdd:COG0666    138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE--AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907154400  179 DVEGKIPLHWAANHKDPSAVHtvrcILDAAptESLLNWQDYEGRTPLHFAVADGNLTVVDVL 240
Cdd:COG0666    216 DNDGKTALDLAAENGNLEIVK----LLLEA--GADLNAKDKDGLTALLLAAAAGAALIVKLL 271
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-328 6.04e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 132.39  E-value: 6.04e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   19 HAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMK 98
Cdd:COG0666     25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVK 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   99 LLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKfmAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIgip 178
Cdd:COG0666    105 LLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE--AGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV--- 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  179 dvegkiplhwaanhkdpsavhtvrcildaaptesllNWQDYEGRTPLHFAVADGNLTVVDVLTSYEScNITSYDNLFRTP 258
Cdd:COG0666    180 ------------------------------------NARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTA 222

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  259 LHWAALLGtfgrHAQIVHLLLERNKSGTIPsDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRT 328
Cdd:COG0666    223 LDLAAENG----NLEIVKLLLEAGADLNAK-DKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
96-528 6.71e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 132.39  E-value: 6.71e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   96 FMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNI 175
Cdd:COG0666      1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  176 GIPDVEGKIPLHWAANHKDpsavhtvrcildaaptesllnwqdyegrtplhfavadgnltvvdvltsyescnitsydnlf 255
Cdd:COG0666     81 NAKDDGGNTLLHAAARNGD------------------------------------------------------------- 99

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  256 rtplhwaallgtfgrhAQIVHLLLErnksgtipsdsQGAtplhyaaqsnfaetvkvflqhpsvkddsdlegrtsfmwaag 335
Cdd:COG0666    100 ----------------LEIVKLLLE-----------AGA----------------------------------------- 111

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  336 kgnddvlrtmlslksdiDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIK 415
Cdd:COG0666    112 -----------------DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE 174

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  416 GGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRT 495
Cdd:COG0666    175 AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLT 254

                          410       420       430
                   ....*....|....*....|....*....|...
gi 1907154400  496 ALHWSCNNGYLDAIKLLLDFAAFPNQMENNEER 528
Cdd:COG0666    255 ALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
6-194 8.91e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.92  E-value: 8.91e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400    6 DVLSTGSSLASQVHAAAVNGDKGALQRLIvGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTAL 85
Cdd:COG0666     79 DINAKDDGGNTLLHAAARNGDLEIVKLLL-EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   86 HLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMApgEVDTQDKNKQTALHWSAYYNNPEHA 165
Cdd:COG0666    158 HLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA--DVNAKDNDGKTALDLAAENGNLEIV 235

                          170       180
                   ....*....|....*....|....*....
gi 1907154400  166 KLLIKHDSNIGIPDVEGKIPLHWAANHKD 194
Cdd:COG0666    236 KLLLEAGADLNAKDKDGLTALLLAAAAGA 264
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
64-359 1.37e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.53  E-value: 1.37e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   64 ADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPgeVD 143
Cdd:COG0666      4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGAD--IN 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  144 TQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAvhtVRCILDA-APteslLNWQDYEGR 222
Cdd:COG0666     82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI---VKLLLEAgAD----VNAQDNDGN 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  223 TPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAALLGtfgrHAQIVHLLLERNKSGTIPsDSQGATPLHYAAQ 302
Cdd:COG0666    155 TPLHLAAANGNLEIVKLLLEA-GADVNARDNDGETPLHLAAENG----HLEIVKLLLEAGADVNAK-DNDGKTALDLAAE 228

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907154400  303 SNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDK 359
Cdd:COG0666    229 NGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-186 5.27e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.50  E-value: 5.27e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   19 HAAAVNGDKGALQRLIvGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMK 98
Cdd:COG0666    125 HLAAYNGNLEIVKLLL-EAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVK 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   99 LLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMApgEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIP 178
Cdd:COG0666    204 LLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA--DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAA 281


                   ....*...
gi 1907154400  179 DVEGKIPL 186
Cdd:COG0666    282 LLDLLTLL 289
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 340-558 5.84e-23

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 102.82  E-value: 5.84e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  340 DVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVST-----VKLLLDNDAQVDATDVMKHTPLFRA--CEMGHRDVIQT 412
Cdd:PHA03100    49 DVVKILL--DNGADINSSTKNNSTPLHYLSNIKYNLTdvkeiVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEY 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  413 LIKGGARVDLVDQDGHSLLHWAALGGNAD--VCQILIENKINPNVQDYagrtplqcaayggyINCmavLMENNADPNIQD 490
Cdd:PHA03100   127 LLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINAKNR--------------VNY---LLSYGVPINIKD 189

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907154400  491 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEerYTPLDYALLGERHEVIQFMLEHGAlSIAAI 558
Cdd:PHA03100   190 VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG--DTPLHIAILNNNKEIFKLLLNNGP-SIKTI 254
Ank_2 pfam12796
Ankyrin repeats (3 copies);
398-490 3.71e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 91.72  E-value: 3.71e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  398 LFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEnKINPNVQDYaGRTPLQCAAYGGYINCMA 477
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1907154400  478 VLMENNADPNIQD 490
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
431-522 5.16e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 91.33  E-value: 5.16e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  431 LHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMEnNADPNIQDkEGRTALHWSCNNGYLDAIK 510
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|..
gi 1907154400  511 LLLDFAAFPNQM 522
Cdd:pfam12796   79 LLLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
365-457 3.90e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 88.63  E-value: 3.90e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  365 LHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKgGARVDLVDqDGHSLLHWAALGGNADVCQ 444
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1907154400  445 ILIENKINPNVQD 457
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 59-420 2.47e-20

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 96.67  E-value: 2.47e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   59 DRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKfma 138
Cdd:PHA02876   156 DELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID--- 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  139 pgevDTQDKNKQTALHWSAYYNNPEHAKLLIkHDSNIGIP--DVEGKIPLHWAAnhKDPSAVHTVRCILDAAPTeslLNW 216
Cdd:PHA02876   233 ----NRSNINKNDLSLLKAIRNEDLETSLLL-YDAGFSVNsiDDCKNTPLHHAS--QAPSLSRLVPKLLERGAD---VNA 302

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  217 QDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLFRTPLHWAAllgTFGRHAQIVHLLLERNkSGTIPSDSQGATP 296
Cdd:PHA02876   303 KNIKGETPLYLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQAS---TLDRNKDIVITLLELG-ANVNARDYCDKTP 378

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  297 LHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNddvlrTMLSLKSDID----INMSDKYGGTALHAAALSG 372
Cdd:PHA02876   379 IHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTN-----PYMSVKTLIDrganVNSKNKDLSTPLHYACKKN 453

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1907154400  373 -HVSTVKLLLDNDAQVDATDVMKHTPLFRAceMGHRDVIQTLIKGGARV 420
Cdd:PHA02876   454 cKLDVIEMLLDNGADVNAINIQNQYPLLIA--LEYHGIVNILLHYGAEL 500
Ank_2 pfam12796
Ankyrin repeats (3 copies);
297-391 3.19e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.32  E-value: 3.19e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  297 LHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLksdIDINMSDkYGGTALHAAALSGHVST 376
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKD-NGRTALHYAARSGHLEI 76

                           90
                   ....*....|....*
gi 1907154400  377 VKLLLDNDAQVDATD 391
Cdd:pfam12796   77 VKLLLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 214-552 5.16e-20

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 95.90  E-value: 5.16e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  214 LNWQDYEGRTPLHFAVADGNLTVVDVLTSYES-CNITSYDNLfrTPLHWA------------------------ALLGTF 268
Cdd:PHA02876   171 VNAKDIYCITPIHYAAERGNAKMVNLLLSYGAdVNIIALDDL--SVLECAvdsknidtikaiidnrsninkndlSLLKAI 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  269 GRHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQS-NFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGND-DVLRTML 346
Cdd:PHA02876   249 RNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQApSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDtENIRTLI 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  347 SLKSDIdiNMSDKYGGTALH-AAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQ 425
Cdd:PHA02876   329 MLGADV--NAADRLYITPLHqASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQ 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  426 DGHSLLHWAALGGNAdvcqilienkinpnvqdyagrtplqcaayggYINcMAVLMENNADPNIQDKEGRTALHWSC-NNG 504
Cdd:PHA02876   407 KIGTALHFALCGTNP-------------------------------YMS-VKTLIDRGANVNSKNKDLSTPLHYACkKNC 454

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 1907154400  505 YLDAIKLLLDFAAFPNQMeNNEERYtPLDYALlgERHEVIQFMLEHGA 552
Cdd:PHA02876   455 KLDVIEMLLDNGADVNAI-NIQNQY-PLLIAL--EYHGIVNILLHYGA 498
Ank_2 pfam12796
Ankyrin repeats (3 copies);
464-552 2.23e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 83.63  E-value: 2.23e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  464 LQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFpnqmENNEERYTPLDYALLGERHEV 543
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV----NLKDNGRTALHYAARSGHLEI 76


                   ....*....
gi 1907154400  544 IQFMLEHGA 552
Cdd:pfam12796   77 VKLLLEKGA 85
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 62-262 4.31e-19

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 91.18  E-value: 4.31e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   62 DCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGE 141
Cdd:PHA02874   105 DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYAN 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  142 VdtQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKdpsavhtvRCILDAAPTESLLNWQDYEG 221
Cdd:PHA02874   185 V--KDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN--------RSAIELLINNASINDQDIDG 254

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1907154400  222 RTPLHFAVA-DGNLTVVDVLTsYESCNITSYDNLFRTPLHWA 262
Cdd:PHA02874   255 STPLHHAINpPCDIDIIDILL-YHKADISIKDNKGENPIDTA 295
Ank_2 pfam12796
Ankyrin repeats (3 copies);
85-179 1.00e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 82.09  E-value: 1.00e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   85 LHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGEVDtqdkNKQTALHWSAYYNNPEH 164
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD----NGRTALHYAARSGHLEI 76

                           90
                   ....*....|....*
gi 1907154400  165 AKLLIKHDSNIGIPD 179
Cdd:pfam12796   77 VKLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 252-499 2.12e-18

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 89.70  E-value: 2.12e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  252 DNLFRTPLHwaALLGTF-GRHAQIVHLLLER----NKSgtipsDSQGATPLHYAAQsnFAETVkvflqhpsvkddsdleg 326
Cdd:PHA03095    44 GEYGKTPLH--LYLHYSsEKVKDIVRLLLEAgadvNAP-----ERCGFTPLHLYLY--NATTL----------------- 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  327 rtsfmwaagkgndDVLRTMLSLKSDIdiNMSDKYGGTALHAAaLSG---HVSTVKLLLDNDAQVDATDVMKHTPL----- 398
Cdd:PHA03095    98 -------------DVIKLLIKAGADV--NAKDKVGRTPLHVY-LSGfniNPKVIRLLLRKGADVNALDLYGMTPLavllk 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  399 FRACEMghrDVIQTLIKGGARVDLVDQDGHSLLHWAALG--GNADVCQILIENKINPNVQDYAGRTPLQCAAYGGyiNCM 476
Cdd:PHA03095   162 SRNANV---ELLRLLIDAGADVYAVDDRFRSLLHHHLQSfkPRARIVRELIRAGCDPAATDMLGNTPLHSMATGS--SCK 236

                          250       260
                   ....*....|....*....|....*..
gi 1907154400  477 AVLM----ENNADPNIQDKEGRTALHW 499
Cdd:PHA03095   237 RSLVlpllIAGISINARNRYGQTPLHY 263
PHA03095 PHA03095
ankyrin-like protein; Provisional
 32-319 6.27e-18

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 88.16  E-value: 6.27e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   32 RLIVGNSALRDKEDRFGRTPLMYCV---LADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGN-YRFMKLLLTRRANW 107
Cdd:PHA03095    31 RRLLAAGADVNFRGEYGKTPLHLYLhysSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADV 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  108 MQKDLEEMTPLH--LSTRHRSPKCLALLLKFMApgEVDTQDKNKQTALHwsAYYN----NPEHAKLLIKHDSNIGIPDVE 181
Cdd:PHA03095   111 NAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGA--DVNALDLYGMTPLA--VLLKsrnaNVELLRLLIDAGADVYAVDDR 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  182 GKIPLHWAAN--HKDPSAVHT-VRCILDAAPTESLlnwqdyeGRTPLHFAVADG---NLTVVDVLTSYESCNITsyDNLF 255
Cdd:PHA03095   187 FRSLLHHHLQsfKPRARIVRElIRAGCDPAATDML-------GNTPLHSMATGSsckRSLVLPLLIAGISINAR--NRYG 257

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907154400  256 RTPLHWAAllgTFGRHAQIVHLLlernKSGTIPS--DSQGATPLHYAAQSNFAETVKVFL-QHPSVK 319
Cdd:PHA03095   258 QTPLHYAA---VFNNPRACRRLI----ALGADINavSSDGNTPLSLMVRNNNGRAVRAALaKNPSAE 317
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 211-425 2.14e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 82.79  E-value: 2.14e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  211 ESLLNWQDYEGRTPLHFAVADGNLTVVDVLTsYESCNITSYDNLFRTPLHWAALLG-TFGRHAQIVHLLLERNKSGTIPs 289
Cdd:PHA03100    25 DDLNDYSYKKPVLPLYLAKEARNIDVVKILL-DNGADINSSTKNNSTPLHYLSNIKyNLTDVKEIVKLLLEYGANVNAP- 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  290 DSQGATPLHYAAQ--SNFAETVKVFLQHPSVKDDSDLEGRTSF-MWAAGKGND-DVLRTMLS--------------LKSD 351
Cdd:PHA03100   103 DNNGITPLLYAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLhLYLESNKIDlKILKLLIDkgvdinaknrvnylLSYG 182

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907154400  352 IDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQ 425
Cdd:PHA03100   183 VPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256
PHA03095 PHA03095
ankyrin-like protein; Provisional
 166-464 1.19e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 80.84  E-value: 1.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  166 KLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAApteSLLNWQDYEGRTPLHFAVADGN-LTVVDVLTSYe 244
Cdd:PHA03095    31 RRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIVRLLLEAG---ADVNAPERCGFTPLHLYLYNATtLDVIKLLIKA- 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  245 SCNITSYDNLFRTPLHwaALLGTFGRHAQIVHLLLERNKSGTiPSDSQGATPLHyaaqsnfaetvkVFLQHPSVkddsdl 324
Cdd:PHA03095   107 GADVNAKDKVGRTPLH--VYLSGFNINPKVIRLLLRKGADVN-ALDLYGMTPLA------------VLLKSRNA------ 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  325 egrtsfmwaagkgNDDVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVST--VKLLLDNDAQVDATDVMKHTPLFRAC 402
Cdd:PHA03095   166 -------------NVELLRLLI--DAGADVYAVDDRFRSLLHHHLQSFKPRAriVRELIRAGCDPAATDMLGNTPLHSMA 230

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907154400  403 EMG--HRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPL 464
Cdd:PHA03095   231 TGSscKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPL 294
Ank_2 pfam12796
Ankyrin repeats (3 copies);
52-146 2.96e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.07  E-value: 2.96e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   52 LMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQkdLEEMTPLHLSTRHRSPKCLA 131
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK--DNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|....*
gi 1907154400  132 LLLKFMApgEVDTQD 146
Cdd:pfam12796   79 LLLEKGA--DINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 348-552 3.70e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 79.30  E-value: 3.70e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  348 LKSDIDINMSDKYGGTALHAAALSGH---VSTVKLLLDNDAQVDATDVMKHTPLFraCEMGH---RDVIQTLIKGGARVD 421
Cdd:PHA03095    34 LAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLH--LYLYNattLDVIKLLIKAGADVN 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  422 LVDQDGHSLLHwAALGG---NADVCQILIENKINPNVQDYAGRTPLqcAAYGGYINC----MAVLMENNADPNIQDKEGR 494
Cdd:PHA03095   112 AKDKVGRTPLH-VYLSGfniNPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSRNAnvelLRLLIDAGADVYAVDDRFR 188

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  495 TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGE--RHEVIQFMLEHGA 552
Cdd:PHA03095   189 SLLHHHLQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGI 248
PHA03095 PHA03095
ankyrin-like protein; Provisional
 39-421 4.69e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 78.91  E-value: 4.69e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   39 ALRDKEDRFGRTPLM-YCVLADRVDCAD--ALLKAGADVNKTDHSRRTALHLaaqkgnyrFMKllltrranwmqkdleem 115
Cdd:PHA03095     2 EEDESVDIIMEAALYdYLLNASNVTVEEvrRLLAAGADVNFRGEYGKTPLHL--------YLH----------------- 56

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  116 tplhlSTRHRSPKCLALLLKfmAPGEVDTQDKNKQTALHWSAYYNN-PEHAKLLIKHDSNIGIPDVEGKIPLHwaanhkd 194
Cdd:PHA03095    57 -----YSSEKVKDIVRLLLE--AGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLH------- 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  195 psaVH-TVRCIlDAAPTESLL------NWQDYEGRTPLHFAV--ADGNLTVVDVLTSyESCNITSYDNLFRTPLHwaALL 265
Cdd:PHA03095   123 ---VYlSGFNI-NPKVIRLLLrkgadvNALDLYGMTPLAVLLksRNANVELLRLLID-AGADVYAVDDRFRSLLH--HHL 195

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  266 GTFGRHAQIVHLLLERNKSGTiPSDSQGATPLHYAAQSNFAETVKV--FLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLR 343
Cdd:PHA03095   196 QSFKPRARIVRELIRAGCDPA-ATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAVFNNPRACR 274

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  344 TMLSLKSDIDINMSDkyGGTALHAAALSGHVSTVKLLLdndAQVDATDVMKHTpLFRACEMGHRD--------VIQTLIK 415
Cdd:PHA03095   275 RLIALGADINAVSSD--GNTPLSLMVRNNNGRAVRAAL---AKNPSAETVAAT-LNTASVAGGDIpsdatrlcVAKVVLR 348


                   ....*.
gi 1907154400  416 GGARVD 421
Cdd:PHA03095   349 GAFSLL 354
Ank_2 pfam12796
Ankyrin repeats (3 copies);
19-111 7.18e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.92  E-value: 7.18e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   19 HAAAVNGDKGALQRLIVGNSALrDKEDRFGRTPLMYCVLADRVDCADALLKaGADVNKTDHsRRTALHLAAQKGNYRFMK 98
Cdd:pfam12796    2 HLAAKNGNLELVKLLLENGADA-NLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1907154400   99 LLLTRRANWMQKD 111
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 17-201 1.19e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 77.76  E-value: 1.19e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   17 QVHAAAVNGDKGALQRLIVGNSALRDKeDRFGRTPLMycVLADRVDCADALLK----AGADVNKTDHSRRTALHLAAQ-- 90
Cdd:PHA03095   122 HVYLSGFNINPKVIRLLLRKGADVNAL-DLYGMTPLA--VLLKSRNANVELLRllidAGADVYAVDDRFRSLLHHHLQsf 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   91 KGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLaLLLKFMAPG-EVDTQDKNKQTALHWSAYYNNPEHAKLLI 169
Cdd:PHA03095   199 KPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRS-LVLPLLIAGiSINARNRYGQTPLHYAAVFNNPRACRRLI 277

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1907154400  170 KHDSNIGIPDVEGKIPLHWAANHKDPSAVHTV 201
Cdd:PHA03095   278 ALGADINAVSSDGNTPLSLMVRNNNGRAVRAA 309
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 338-536 1.52e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 77.31  E-value: 1.52e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  338 NDDVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGG 417
Cdd:PHA02874   103 EKDMIKTIL--DCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKG 180

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  418 ARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYggYINCMAVLMENNADPNIQDKEGRTAL 497
Cdd:PHA02874   181 AYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPL 258

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1907154400  498 HWSCNNG-YLDAIKLLLDFAAFPNQMENNEEryTPLDYAL 536
Cdd:PHA02874   259 HHAINPPcDIDIIDILLYHKADISIKDNKGE--NPIDTAF 296
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 354-561 2.24e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 76.54  E-value: 2.24e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  354 INMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMG-----------------------HRDVI 410
Cdd:PHA02874    28 INISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGahdiikllidngvdtsilpipciEKDMI 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  411 QTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 490
Cdd:PHA02874   108 KTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKD 187

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907154400  491 KEGRTALHWSCNNGYLDAIKLLLDFAAfpNQMENNEERYTPLDYALLGERhEVIQFMLEHGALSiaaIQDI 561
Cdd:PHA02874   188 NNGESPLHNAAEYGDYACIKLLIDHGN--HIMNKCKNGFTPLHNAIIHNR-SAIELLINNASIN---DQDI 252
Ank_2 pfam12796
Ankyrin repeats (3 copies);
153-252 2.57e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.37  E-value: 2.57e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  153 LHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDpsaVHTVRCILDAAPTESllnwqDYEGRTPLHFAVADG 232
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGH---LEIVKLLLEHADVNL-----KDNGRTALHYAARSG 72

                           90       100
                   ....*....|....*....|
gi 1907154400  233 NLTVVDVLTSYEsCNITSYD 252
Cdd:pfam12796   73 HLEIVKLLLEKG-ADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
225-323 3.25e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 3.25e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  225 LHFAVADGNLTVVDVLTSYEsCNITSYDNLFRTPLHWAALLGtfgrHAQIVHLLLERNKSGtipSDSQGATPLHYAAQSN 304
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNG----HLEIVKLLLEHADVN---LKDNGRTALHYAARSG 72

                           90
                   ....*....|....*....
gi 1907154400  305 FAETVKVFLQHPSVKDDSD 323
Cdd:pfam12796   73 HLEIVKLLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 374-552 3.51e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 75.86  E-value: 3.51e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  374 VSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAA-----LGGNADVCQILIE 448
Cdd:PHA03100    15 VKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSnikynLTDVKEIVKLLLE 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  449 NKINPNVQDYAGRTPLQCAAYG--GYINCMAVLMENNADPNIQDKEGRTALHW--SCNNGYLDAIKLLLDFAAFPNQMEN 524
Cdd:PHA03100    95 YGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLylESNKIDLKILKLLIDKGVDINAKNR 174

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1907154400  525 --------------NEERYTPLDYALLGERHEVIQFMLEHGA 552
Cdd:PHA03100   175 vnyllsygvpinikDVYGFTPLHYAVYNNNPEFVKYLLDLGA 216
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 365-533 4.03e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 75.80  E-value: 4.03e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  365 LHAAALSGHVSTVKLLLDNDAQVDatDVM---KHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 441
Cdd:PHA02875    72 LHDAVEEGDVKAVEELLDLGKFAD--DVFykdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  442 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR-TALHWSCNNGYLDAIKLLLDFAAFPN 520
Cdd:PHA02875   150 GIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGADCN 229

                          170
                   ....*....|....
gi 1907154400  521 QMENNE-ERYTPLD 533
Cdd:PHA02875   230 IMFMIEgEECTILD 243
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 215-455 6.46e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 75.03  E-value: 6.46e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  215 NWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLfRTPLHWAALLGTfgrhAQIVHLLLERNKSGTIPSDSQGA 294
Cdd:PHA02875    29 NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDI-ESELHDAVEEGD----VKAVEELLDLGKFADDVFYKDGM 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  295 TPLHYAAQSNfaetvkvflqhpsvkddsdlegrtsfmwaagkgNDDVLRTMLSLKSDIDINMSDKYggTALHAAALSGHV 374
Cdd:PHA02875   104 TPLHLATILK---------------------------------KLDIMKLLIARGADPDIPNTDKF--SPLHLAVMMGDI 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  375 STVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGH-SLLHWAALGGNADVCQILIENKINP 453
Cdd:PHA02875   149 KGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGADC 228


                   ..
gi 1907154400  454 NV 455
Cdd:PHA02875   229 NI 230
PHA03095 PHA03095
ankyrin-like protein; Provisional
 18-238 9.73e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 75.06  E-value: 9.73e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   18 VHAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVD--CADALLKAGADVNKTDHSRRTALH--LAAQKGN 93
Cdd:PHA03095    87 LHLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVYLSGFNINpkVIRLLLRKGADVNALDLYGMTPLAvlLKSRNAN 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   94 YRFMKLLLTRRANWMQKDLEEMTPLH---LSTRHRSPKCLALLLKFMAPGEVDTQDknkQTALHWSAYYNNPEHAKL--L 168
Cdd:PHA03095   167 VELLRLLIDAGADVYAVDDRFRSLLHhhlQSFKPRARIVRELIRAGCDPAATDMLG---NTPLHSMATGSSCKRSLVlpL 243

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907154400  169 IKHDSNIGIPDVEGKIPLHWAANHKDPSAVhtVRCI-LDAAPtesllNWQDYEGRTPLHFAVADGNLTVVD 238
Cdd:PHA03095   244 LIAGISINARNRYGQTPLHYAAVFNNPRAC--RRLIaLGADI-----NAVSSDGNTPLSLMVRNNNGRAVR 307
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 228-502 3.55e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 72.72  E-value: 3.55e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  228 AVADGNLTVVD-VLTSYESCNITSYDNLfrTPLHWAALLgtfgRHAQIVHLLLernKSGTIPSDSQGA--TPLHYAAQSN 304
Cdd:PHA02875     9 AILFGELDIARrLLDIGINPNFEIYDGI--SPIKLAMKF----RDSEAIKLLM---KHGAIPDVKYPDieSELHDAVEEG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  305 FAETVKVFLQHPSVKDDSDL-EGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDKYggTALHAAALSGHVSTVKLLLDN 383
Cdd:PHA02875    80 DVKAVEELLDLGKFADDVFYkDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKF--SPLHLAVMMGDIKGIELLIDH 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  384 DAQVDATDVMKHTPLFracemghrdviqtlikggarvdlvdqdghsllhWAALGGNADVCQILIENKINPNvqdYAGRTP 463
Cdd:PHA02875   158 KACLDIEDCCGCTPLI---------------------------------IAMAKGDIAICKMLLDSGANID---YFGKNG 201

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1907154400  464 ---LQCAAY-GGYINCMAVLMENNADPNIQ---DKEGRTALHWSCN 502
Cdd:PHA02875   202 cvaALCYAIeNNKIDIVRLFIKRGADCNIMfmiEGEECTILDMICN 247
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 258-537 4.98e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 72.61  E-value: 4.98e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  258 PLHWAALlgtfGRHAQIVHLLLERNKSGTIPsDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWaaGKG 337
Cdd:PHA02878    40 PLHQAVE----ARNLDVVKSLLTRGHNVNQP-DHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAIKDAF--NNR 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  338 NDDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVstVKLLLDNDAQVDATDVMK-HTPLFRACEMGHRDVIQTLIKG 416
Cdd:PHA02878   113 NVEIFKIILTNRYKNIQTIDLVYIDKKSKDDIIEAEI--TKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSY 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  417 GARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAygGY---INCMAVLMENNADPNIQDK-E 492
Cdd:PHA02878   191 GANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV--GYckdYDILKLLLEHGVDVNAKSYiL 268

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1907154400  493 GRTALHWSCNNGylDAIKLLLDFAAFPNQMenNEERYTPLDYALL 537
Cdd:PHA02878   269 GLTALHSSIKSE--RKLKLLLEYGADINSL--NSYKLTPLSSAVK 309
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 92-481 7.36e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 71.92  E-value: 7.36e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   92 GNYRFMKLLLTRRANWMQKDLEE-MTPLHLSTRHRSPKCLALLLKFMApgEVDTQDKNKQTALHWSAYYNNPEHAKLLIK 170
Cdd:PHA02874    12 GDIEAIEKIIKNKGNCINISVDEtTTPLIDAIRSGDAKIVELFIKHGA--DINHINTKIPHPLLTAIKIGAHDIIKLLID 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  171 H--DSNI-GIPDVEGKiplhwaanhkdpsavhTVRCILDAAPTeslLNWQDYEGRTPLHFAVADGNLTVVDVLTSYES-C 246
Cdd:PHA02874    90 NgvDTSIlPIPCIEKD----------------MIKTILDCGID---VNIKDAELKTFLHYAIKKGDLESIKMLFEYGAdV 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  247 NItsydnlfrtplhwaallgtfgrhaqivhlllernksgtipSDSQGATPLHYAAQSNFAETVKVFLQHPSVkddsdleg 326
Cdd:PHA02874   151 NI----------------------------------------EDDNGCYPIHIAIKHNFFDIIKLLLEKGAY-------- 182

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  327 rtsfmwaagkgnddvlrtmlslksdidINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACeMGH 406
Cdd:PHA02874   183 ---------------------------ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAI-IHN 234

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907154400  407 RDVIQTLIKgGARVDLVDQDGHSLLHWA-ALGGNADVCQILIENKINPNVQDYAGRTPLQCAAygGYINCMAVLME 481
Cdd:PHA02874   235 RSAIELLIN-NASINDQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKDNKGENPIDTAF--KYINKDPVIKD 307
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 224-497 3.34e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 69.91  E-value: 3.34e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  224 PLHFAVADGNLTVVDVLTSyESCNITSYDNLFRTPLHWAA----LLGtfgrhaqIVHLLLERNKSGTIPSDSQGATPLHY 299
Cdd:PHA02878    40 PLHQAVEARNLDVVKSLLT-RGHNVNQPDHRDLTPLHIICkepnKLG-------MKEMIRSINKCSVFYTLVAIKDAFNN 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  300 aaqsNFAETVKVFL--QHPSVKDDSDLEGRTsfmwaagKGNDDVLRTM---LSLKSDIDINMSDKYGG-TALHAAALSGH 373
Cdd:PHA02878   112 ----RNVEIFKIILtnRYKNIQTIDLVYIDK-------KSKDDIIEAEitkLLLSYGADINMKDRHKGnTALHYATENKD 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  374 VSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWA-ALGGNADVCQILIENKIN 452
Cdd:PHA02878   181 QRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISvGYCKDYDILKLLLEHGVD 260

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1907154400  453 PNVQDYA-GRTPLQCAAYGGYIncMAVLMENNADPNIQDKEGRTAL 497
Cdd:PHA02878   261 VNAKSYIlGLTALHSSIKSERK--LKLLLEYGADINSLNSYKLTPL 304
Ank_2 pfam12796
Ankyrin repeats (3 copies);
186-282 3.56e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.21  E-value: 3.56e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  186 LHWAANHKDPSAVHT-VRCILDAaptesllNWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDnlfRTPLHWAAL 264
Cdd:pfam12796    1 LHLAAKNGNLELVKLlLENGADA-------NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNG---RTALHYAAR 70

                           90
                   ....*....|....*...
gi 1907154400  265 LGtfgrHAQIVHLLLERN 282
Cdd:pfam12796   71 SG----HLEIVKLLLEKG 84
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 67-229 1.78e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 67.60  E-value: 1.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   67 LLKAGADVNKTD-HSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMApgEVDTQ 145
Cdd:PHA02878   153 LLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA--STDAR 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  146 DKNKQTALHWS-AYYNNPEHAKLLIKHDSNIGIPD-VEGKIPLHWAANHKDpsavhTVRCILDAAPTESLLNWqdyEGRT 223
Cdd:PHA02878   231 DKCGNTPLHISvGYCKDYDILKLLLEHGVDVNAKSyILGLTALHSSIKSER-----KLKLLLEYGADINSLNS---YKLT 302


                   ....*.
gi 1907154400  224 PLHFAV 229
Cdd:PHA02878   303 PLSSAV 308
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 49-205 4.31e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 66.23  E-value: 4.31e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   49 RTPLMYC-----VLADRVDCADALLKAGADVNKTDHSRRTALHLAAQK--GNYRFMKLLLTRRANWMQKDLEEMTPLHLS 121
Cdd:PHA03100    69 STPLHYLsnikyNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLY 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  122 TRHRSPKC------------------LALLLKFMAPgeVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGK 183
Cdd:PHA03100   149 LESNKIDLkilkllidkgvdinaknrVNYLLSYGVP--INIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGD 226

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1907154400  184 IPLHWAA--NHKD---------PSAVHTVRCIL 205
Cdd:PHA03100   227 TPLHIAIlnNNKEifklllnngPSIKTIIETLL 259
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 61-359 6.29e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 66.06  E-value: 6.29e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   61 VDCADALLKAGADVNKTDHSRRTA-------LHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHrsPKCLAll 133
Cdd:PHA02878    10 TDNYETILKYIEYIDHTENYSTSAslipfipLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKE--PNKLG-- 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  134 LKFMAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLI--KHDSNIGIPDVEGKiplhwAANHKDPSAVHTVRCILDAAPTE 211
Cdd:PHA02878    86 MKEMIRSINKCSVFYTLVAIKDAFNNRNVEIFKIILtnRYKNIQTIDLVYID-----KKSKDDIIEAEITKLLLSYGADI 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  212 SLLNwqDYEGRTPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAAllgtfgRHAQ--IVHLLLeRNKSGTIPS 289
Cdd:PHA02878   161 NMKD--RHKGNTALHYATENKDQRLTELLLSY-GANVNIPDKTNNSPLHHAV------KHYNkpIVHILL-ENGASTDAR 230

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907154400  290 DSQGATPLHYAAQSNFA-ETVKVFLQH-PSVKDDSDLEGRTSFMWAAgkGNDDVLRTMLSLKSDIDINMSDK 359
Cdd:PHA02878   231 DKCGNTPLHISVGYCKDyDILKLLLEHgVDVNAKSYILGLTALHSSI--KSERKLKLLLEYGADINSLNSYK 300
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 617-890 1.02e-10

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 66.35  E-value: 1.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  617 LDTDPPRSHCSSSAPvlPCPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKPS 696
Cdd:PHA03307   176 LSSPEETARAPSSPP--AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPEN 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  697 ETPIEHcrgPSACVHP-RSWEGGNSSKNQGTSSVEKRRGETNGKHRRCEegPSSARQPLCTGSGRPAEKGEDSSPAVASA 775
Cdd:PHA03307   254 ECPLPR---PAPITLPtRIWEASGWNGPSSRPGPASSSSSPRERSPSPS--PSSPGSGPAPSSPRASSSSSSSRESSSSS 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  776 SQQDHP--------------RKPNKRQDRAARPRGASQKRRTHQLRDRCSPAGSSRPGSAKGEVACADQSSLHRHTPRsk 841
Cdd:PHA03307   329 TSSSSEssrgaavspgpspsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR-- 406

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907154400  842 vtqdkLIGGVSSGLPLSTEASRSGCKQLYEDI--CASPETGVAhGPPPGQC 890
Cdd:PHA03307   407 -----FPAGRPRPSPLDAGAASGAFYARYPLLtpSGEPWPGSP-PPPPGRV 451
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 302-485 1.82e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 65.27  E-value: 1.82e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  302 QSNFAETVKVFLQH--------------PSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDInmSDKYGGTALHA 367
Cdd:PLN03192   487 QEDNVVILKNFLQHhkelhdlnvgdllgDNGGEHDDPNMASNLLTVASTGNAALLEELLKAKLDPDI--GDSKGRTPLHI 564

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  368 AALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDlvDQDGHSLLHWAALGGNADVCQILI 447
Cdd:PLN03192   565 AASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISD--PHAAGDLLCTAAKRNDLTAMKELL 642

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1907154400  448 ENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNAD 485
Cdd:PLN03192   643 KQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680
PHA02798 PHA02798
ankyrin-like protein; Provisional
 374-533 1.90e-10

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 64.47  E-value: 1.90e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  374 VSTVKLLLdndAQVDATDVMKHTPLFRacEMGHR-----DVIQTLIKGGARVDLVDQDGHS-----LLHWAALGGNADVC 443
Cdd:PHA02798    18 LSTVKLLI---KSCNPNEIVNEYSIFQ--KYLQRdspstDIVKLFINLGANVNGLDNEYSTplctiLSNIKDYKHMLDIV 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  444 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL---MENNADPNIQDKEGRTALH---WSCNNGYLDAIKLLLDFAA 517
Cdd:PHA02798    93 KILIENGADINKKNSDGETPLYCLLSNGYINNLEILlfmIENGADTTLLDKDGFTMLQvylQSNHHIDIEIIKLLLEKGV 172

                          170
                   ....*....|....*.
gi 1907154400  518 FPNQMeNNEERYTPLD 533
Cdd:PHA02798   173 DINTH-NNKEKYDTLH 187
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 278-481 3.39e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 64.12  E-value: 3.39e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  278 LLERNKSGTIpSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSfMW------------------------- 332
Cdd:PLN03192   544 LLKAKLDPDI-GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTA-LWnaisakhhkifrilyhfasisdpha 621

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  333 -------AAGKGNDDVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDAT---DVMKHTPLFRAC 402
Cdd:PLN03192   622 agdllctAAKRNDLTAMKELL--KQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAntdDDFSPTELRELL 699

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  403 ---EMGHRDVIqtlikggarVDLVDQDgHSLLHWAALGGNADVCQILIENKINPNVQDYAG----RTPLQCAAYGGYINC 475
Cdd:PLN03192   700 qkrELGHSITI---------VDSVPAD-EPDLGRDGGSRPGRLQGTSSDNQCRPRVSIYKGhpllRNERCCNEAGKLINL 769


                   ....*.
gi 1907154400  476 MAVLME 481
Cdd:PLN03192   770 PPSLEE 775
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 16-175 3.78e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 63.47  E-value: 3.78e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   16 SQVHAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYR 95
Cdd:PHA02875    70 SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   96 FMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMApgEVDTQDKNKQTALHWSAYYNN-PEHAKLLIKH--D 172
Cdd:PHA02875   150 GIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGA--NIDYFGKNGCVAALCYAIENNkIDIVRLFIKRgaD 227


                   ...
gi 1907154400  173 SNI 175
Cdd:PHA02875   228 CNI 230
Ank_4 pfam13637
Ankyrin repeats (many copies);
427-479 3.85e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 56.13  E-value: 3.85e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907154400  427 GHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 479
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
361-414 5.31e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.74  E-value: 5.31e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907154400  361 GGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLI 414
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
326-381 7.63e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.36  E-value: 7.63e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907154400  326 GRTSFMWAAGKGNDDVLRTMLSLKsdIDINMSDKYGGTALHAAALSGHVSTVKLLL 381
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKG--ADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
460-513 1.19e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.97  E-value: 1.19e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907154400  460 GRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 513
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
48-101 1.67e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.59  E-value: 1.67e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907154400   48 GRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLL 101
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 339-562 5.24e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 60.46  E-value: 5.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  339 DDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGA 418
Cdd:PHA02876   156 DELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRS 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  419 RV---DL--------VDQDGHSLLHWAALGGNA-DVCQ------------------ILIENKINPNVQDYAGRTPLQCAA 468
Cdd:PHA02876   236 NInknDLsllkairnEDLETSLLLYDAGFSVNSiDDCKntplhhasqapslsrlvpKLLERGADVNAKNIKGETPLYLMA 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  469 YGGY-INCMAVLMENNADPNIQDKEGRTALHWSCN-NGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGERHEVIQF 546
Cdd:PHA02876   316 KNGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDK--TPIHYAAVRNNVVIINT 393

                          250
                   ....*....|....*.
gi 1907154400  547 MLEHGALSIAAIQDIA 562
Cdd:PHA02876   394 LLDYGADIEALSQKIG 409
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 48-248 5.56e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 59.62  E-value: 5.56e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   48 GRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTrrANWMQKDL---EEMTPLHLSTRH 124
Cdd:PHA02875    35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLD--LGKFADDVfykDGMTPLHLATIL 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  125 RSPKCLALLLKFMAPGEVDTQDKNkqTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDpsaVHTVRCI 204
Cdd:PHA02875   113 KKLDIMKLLIARGADPDIPNTDKF--SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGD---IAICKML 187

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1907154400  205 LDAAPTesllnwQDYEGRTP----LHFAVADGNLTVVDVLTSYES-CNI 248
Cdd:PHA02875   188 LDSGAN------IDYFGKNGcvaaLCYAIENNKIDIVRLFIKRGAdCNI 230
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 34-243 5.87e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 59.68  E-value: 5.87e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   34 IVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQ-----KGNYRFMKLLLTRRANWM 108
Cdd:PHA03100    21 IIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNikynlTDVKEIVKLLLEYGANVN 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  109 QKDLEEMTPLH--LSTRHRSPKCLALLLKFMApgevDTQDKNK--QTALHWSAYYNNPE------------------HAK 166
Cdd:PHA03100   101 APDNNGITPLLyaISKKSNSYSIVEYLLDNGA----NVNIKNSdgENLLHLYLESNKIDlkilkllidkgvdinaknRVN 176

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907154400  167 LLIKHDSNIGIPDVEGKIPLHWAANHKDPSavhTVRCILD--AAPtesllNWQDYEGRTPLHFAVADGNLTVVDVLTSY 243
Cdd:PHA03100   177 YLLSYGVPINIKDVYGFTPLHYAVYNNNPE---FVKYLLDlgANP-----NLVNKYGDTPLHIAILNNNKEIFKLLLNN 247
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 430-513 6.26e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 59.91  E-value: 6.26e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  430 LLHWAAlGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAI 509
Cdd:PTZ00322    86 LCQLAA-SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV 164


                   ....
gi 1907154400  510 KLLL 513
Cdd:PTZ00322   165 QLLS 168
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 364-552 7.10e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 59.23  E-value: 7.10e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  364 ALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNA-DV 442
Cdd:PHA02875     5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVkAV 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  443 CQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNqM 522
Cdd:PHA02875    85 EELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLD-I 163

                          170       180       190
                   ....*....|....*....|....*....|
gi 1907154400  523 ENNEErYTPLDYALLGERHEVIQFMLEHGA 552
Cdd:PHA02875   164 EDCCG-CTPLIIAMAKGDIAICKMLLDSGA 192
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 478-550 7.75e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 59.53  E-value: 7.75e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907154400  478 VLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGERHEVIQFMLEH 550
Cdd:PTZ00322   100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGK--TPLELAEENGFREVVQLLSRH 170
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 295-501 8.20e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 59.64  E-value: 8.20e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  295 TPLHYAAQSNFAETVKVFLQHPSVkddsDLE-----GRTSFMWAAGKGNDDVLRTMLSLKSDIdINM---SDKYGG-TAL 365
Cdd:cd22192     19 SPLLLAAKENDVQAIKKLLKCPSC----DLFqrgalGETALHVAALYDNLEAAVVLMEAAPEL-VNEpmtSDLYQGeTAL 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  366 HAAALSGHVSTVKLLLDNDAQV---DATDVM------------KHTPLFRACeMGHRDVIQTLIKGGArvDLVDQD--GH 428
Cdd:cd22192     94 HIAVVNQNLNLVRELIARGADVvspRATGTFfrpgpknliyygEHPLSFAAC-VGNEEIVRLLIEHGA--DIRAQDslGN 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  429 SLLHWAALGGNAD-VCQI--LI---ENKINP----NVQDYAGRTPLQCAAYGGYINCMAVLMENnadpniqdkegRTALH 498
Cdd:cd22192    171 TVLHILVLQPNKTfACQMydLIlsyDKEDDLqpldLVPNNQGLTPFKLAAKEGNIVMFQHLVQK-----------RRHIQ 239


                   ...
gi 1907154400  499 WSC 501
Cdd:cd22192    240 WTY 242
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 222-404 3.16e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.31  E-value: 3.16e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  222 RTPLHFAVADGNLTVVDVLTSYEscniTSYDNLF----RTPLHwaalLGTFGRHAQIVHLLLERNKSGTIPSDSQgATPL 297
Cdd:PHA02875    69 ESELHDAVEEGDVKAVEELLDLG----KFADDVFykdgMTPLH----LATILKKLDIMKLLIARGADPDIPNTDK-FSPL 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  298 HYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSlkSDIDINMSDKYGGTALHAAALSGH-VST 376
Cdd:PHA02875   140 HLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLD--SGANIDYFGKNGCVAALCYAIENNkIDI 217

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1907154400  377 VKLLLDNDAQVD-ATDVM--KHTPLFRACEM 404
Cdd:PHA02875   218 VRLFIKRGADCNiMFMIEgeECTILDMICNM 248
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 296-552 7.55e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 56.04  E-value: 7.55e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  296 PLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDKYGGTALHaaalSGHVS 375
Cdd:PHA02878    40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAIKDAFN----NRNVE 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  376 TVKLLLDNDAQVDATDVMKHTplfraCEMGHRDVIQT-----LIKGGARVDLVDQD-GHSLLHWAALGGNADVCQILIEN 449
Cdd:PHA02878   116 IFKIILTNRYKNIQTIDLVYI-----DKKSKDDIIEAeitklLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSY 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  450 KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCnnGYLdaikllldfaafpnqmenneery 529
Cdd:PHA02878   191 GANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV--GYC----------------------- 245

                          250       260
                   ....*....|....*....|...
gi 1907154400  530 tpLDYallgerhEVIQFMLEHGA 552
Cdd:PHA02878   246 --KDY-------DILKLLLEHGV 259
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 434-520 8.75e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 56.41  E-value: 8.75e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  434 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 513
Cdd:PLN03192   532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611


                   ....*..
gi 1907154400  514 DFAAFPN 520
Cdd:PLN03192   612 HFASISD 618
Ank_4 pfam13637
Ankyrin repeats (many copies);
396-447 1.18e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 1.18e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907154400  396 TPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILI 447
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
446-498 6.71e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.34  E-value: 6.71e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907154400  446 LIENK-INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALH 498
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 369-446 2.24e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.82  E-value: 2.24e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907154400  369 ALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQIL 446
Cdd:PTZ00322    90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
Ank_5 pfam13857
Ankyrin repeats (many copies);
483-535 2.40e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.42  E-value: 2.40e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907154400  483 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNqmENNEERYTPLDYA 535
Cdd:pfam13857    6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLN--LKDEEGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
67-120 2.73e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.42  E-value: 2.73e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1907154400   67 LLKAG-ADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 120
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 150-338 2.92e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 2.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  150 QTALHWSAYYNNPEHAKLLikhdsnigipdvegkiplhwaanhkdpsavhtvrciLDAAPTesLLNW----QDYEGRTPL 225
Cdd:cd22192     52 ETALHVAALYDNLEAAVVL------------------------------------MEAAPE--LVNEpmtsDLYQGETAL 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  226 HFAVADGNLTVVDVLTSYESCNIT----------SYDNLF---RTPLHWAALLGtfgrHAQIVHLLLERNKSgTIPSDSQ 292
Cdd:cd22192     94 HIAVVNQNLNLVRELIARGADVVSpratgtffrpGPKNLIyygEHPLSFAACVG----NEEIVRLLIEHGAD-IRAQDSL 168

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907154400  293 GATPLHY---AAQSNFA-ETVKVFLQHPSVKDDSDLE------GRTSFMWAAGKGN 338
Cdd:cd22192    169 GNTVLHIlvlQPNKTFAcQMYDLILSYDKEDDLQPLDlvpnnqGLTPFKLAAKEGN 224
Ank_5 pfam13857
Ankyrin repeats (many copies);
416-467 3.26e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.42  E-value: 3.26e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907154400  416 GGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCA 467
Cdd:pfam13857    5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 348-415 3.31e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.05  E-value: 3.31e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907154400  348 LKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIK 415
Cdd:PTZ00322   102 LTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
Ank_4 pfam13637
Ankyrin repeats (many copies);
493-548 4.32e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.96  E-value: 4.32e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907154400  493 GRTALHWSCNNGYLDAIKLLLDFAAFPNqmENNEERYTPLDYALLGERHEVIQFML 548
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADIN--AVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 32-186 7.57e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.88  E-value: 7.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   32 RLIVGNSALRDKEDR-FGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQK 110
Cdd:PHA02878   151 KLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDAR 230

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907154400  111 DLEEMTPLHLST-RHRSPKCLALLLKFMAPGEVDTQDKNkQTALHWSayYNNPEHAKLLIKHDSNIGIPDVEGKIPL 186
Cdd:PHA02878   231 DKCGNTPLHISVgYCKDYDILKLLLEHGVDVNAKSYILG-LTALHSS--IKSERKLKLLLEYGADINSLNSYKLTPL 304
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 239-327 7.98e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.90  E-value: 7.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  239 VLTSYESCNITSYDNlfRTPLHWAALLGtfgrHAQIVHLLLERNKSGTIpSDSQGATPLHYAAQSNFAETVKVFLQHPsv 318
Cdd:PTZ00322   101 LLTGGADPNCRDYDG--RTPLHIACANG----HVQVVRVLLEFGADPTL-LDKDGKTPLELAEENGFREVVQLLSRHS-- 171


                   ....*....
gi 1907154400  319 KDDSDLEGR 327
Cdd:PTZ00322   172 QCHFELGAN 180
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 21-236 9.03e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 49.63  E-value: 9.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   21 AAVNGDKGALQRLIVGNSAlrDKEDR--FGRTPLMYCVLADRVDCADALLKAGAD-VNKTDHSR----RTALHLAAQKGN 93
Cdd:cd22192     24 AAKENDVQAIKKLLKCPSC--DLFQRgaLGETALHVAALYDNLEAAVVLMEAAPElVNEPMTSDlyqgETALHIAVVNQN 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   94 YRFMKLLLTRRAnwmqkdlEEMTPLHLSTR-HRSPKClalLLKFmapGEvdtqdknkqTALHWSAYYNNPEHAKLLIKHD 172
Cdd:cd22192    102 LNLVRELIARGA-------DVVSPRATGTFfRPGPKN---LIYY---GE---------HPLSFAACVGNEEIVRLLIEHG 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907154400  173 SNIGIPDVEGKIPLH---WAANHKdpSAVHTVRCIL------DAAPTESLLNwqdYEGRTPLHFAVADGNLTV 236
Cdd:cd22192    160 ADIRAQDSLGNTVLHilvLQPNKT--FACQMYDLILsydkedDLQPLDLVPN---NQGLTPFKLAAKEGNIVM 227
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 13-153 1.01e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.49  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   13 SLASQVHAAAVNGDKgALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQK- 91
Cdd:PHA02878   167 KGNTALHYATENKDQ-RLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYc 245

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907154400   92 GNYRFMKLLLTRRANW-MQKDLEEMTPLHLSTrhRSPKCLALLLKFMApgEVDTQDKNKQTAL 153
Cdd:PHA02878   246 KDYDILKLLLEHGVDVnAKSYILGLTALHSSI--KSERKLKLLLEYGA--DINSLNSYKLTPL 304
Ank_4 pfam13637
Ankyrin repeats (many copies);
81-134 1.60e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.03  E-value: 1.60e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907154400   81 RRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLL 134
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
139-189 2.10e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 2.10e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907154400  139 PGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWA 189
Cdd:pfam13857    6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 911-936 4.27e-05

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 41.37  E-value: 4.27e-05
                           10        20
                   ....*....|....*....|....*.
gi 1907154400  911 RKELFRRKNKAAAVIQRAWRSYQLRK 936
Cdd:cd23767      1 EEEELQRMNRAATLIQALWRGYKVRK 26
PHA03378 PHA03378
EBNA-3B; Provisional
 616-880 4.71e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 47.75  E-value: 4.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  616 QLDTDPPRSHCSSSAPVLPCPPSPQNEASKQDATPSKQppaSHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKP 695
Cdd:PHA03378   575 QPLTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQ---SHIPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTP 651

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  696 SETP-IEHCRGPSACVHPRSWEGGNSSKNQGTSsveKRRGETNGKHRRCEEGPSSARQPLC--TGSGRPAEKGEDSSPAV 772
Cdd:PHA03378   652 HQPPqVEITPYKPTWTQIGHIPYQPSPTGANTM---LPIQWAPGTMQPPPRAPTPMRPPAAppGRAQRPAAATGRARPPA 728

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  773 ASASQQDHP-------RKPNKRQDRAARPRGASQKRR-------------------THQLRDRCSPAGSSRPGSAKGEVA 826
Cdd:PHA03378   729 AAPGRARPPaaapgraRPPAAAPGRARPPAAAPGRARppaaapgaptpqpppqappAPQQRPRGAPTPQPPPQAGPTSMQ 808

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907154400  827 CADQSSLHRHTPRSKVTQDKLIGGVSSGLPLSTEASRsGCKQLYEDICASPETG 880
Cdd:PHA03378   809 LMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAA-LERQAAAGPTPSPGSG 861
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 410-480 5.54e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.20  E-value: 5.54e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907154400  410 IQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM 480
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 393-552 8.00e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.52  E-value: 8.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  393 MKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 472
Cdd:PHA02875     1 MDQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  473 INCMAVLMENNADPN-IQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQmeNNEERYTPLDYALLGERHEVIQFMLEHG 551
Cdd:PHA02875    81 VKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDI--PNTDKFSPLHLAVMMGDIKGIELLIDHK 158


                   .
gi 1907154400  552 A 552
Cdd:PHA02875   159 A 159
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 360-391 1.35e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 1.35e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907154400  360 YGGTALHAAALS-GHVSTVKLLLDNDAQVDATD 391
Cdd:pfam00023    1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 48-76 1.90e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 1.90e-04
                            10        20
                    ....*....|....*....|....*....
gi 1907154400    48 GRTPLMYCVLADRVDCADALLKAGADVNK 76
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 48-79 2.44e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.19  E-value: 2.44e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907154400   48 GRTPLMYCVL-ADRVDCADALLKAGADVNKTDH 79
Cdd:pfam00023    2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
Ank_5 pfam13857
Ankyrin repeats (many copies);
351-398 2.76e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.64  E-value: 2.76e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1907154400  351 DIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPL 398
Cdd:pfam13857    6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
256-313 3.30e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 3.30e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907154400  256 RTPLHWAALLGtfgrHAQIVHLLLERNKSGTIpSDSQGATPLHYAAQSNFAETVKVFL 313
Cdd:pfam13637    2 LTALHAAAASG----HLELLRLLLEKGADINA-VDGNGETALHFAASNGNVEVLKLLL 54
PHA02791 PHA02791
ankyrin-like protein; Provisional
 218-415 3.57e-04

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 43.88  E-value: 3.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  218 DYEGRTPLHFAVADGNLTVVDVLTsyescNITSYDNLFRT--PLHWAALLgtfgRHAQIVHLLLernKSGTIPS--DSQG 293
Cdd:PHA02791    27 DVHGHSALYYAIADNNVRLVCTLL-----NAGALKNLLENefPLHQAATL----EDTKIVKILL---FSGMDDSqfDDKG 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  294 ATPLHYAAQSNFAETVKVFLQHP-SVKDDSDLEGRTSFMWAAGKGNDDVLRTMLS-LKSDIDINMSDkyggTALHAAALS 371
Cdd:PHA02791    95 NTALYYAVDSGNMQTVKLFVKKNwRLMFYGKTGWKTSFYHAVMLNDVSIVSYFLSeIPSTFDLAILL----SCIHITIKN 170

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1907154400  372 GHVSTVKLLLDNDAQVDATDVMKHTPLFR-ACEMGHRDVIQTLIK 415
Cdd:PHA02791   171 GHVDMMILLLDYMTSTNTNNSLLFIPDIKlAIDNKDLEMLQALFK 215
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 426-455 3.64e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 3.64e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 1907154400   426 DGHSLLHWAALGGNADVCQILIENKINPNV 455
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
221-279 4.34e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 4.34e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907154400  221 GRTPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAAllgtFGRHAQIVHLLL 279
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAA----SNGNVEVLKLLL 54
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 557-583 5.55e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 38.29  E-value: 5.55e-04
                           10        20
                   ....*....|....*....|....*..
gi 1907154400  557 AIQDIAAFKIQAVYKGYKVRKAFRDRK 583
Cdd:cd23767      6 QRMNRAATLIQALWRGYKVRKELKKKK 32
Ank_5 pfam13857
Ankyrin repeats (many copies);
33-88 6.64e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 6.64e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907154400   33 LIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLA 88
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 228-481 6.77e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.53  E-value: 6.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  228 AVADGNLTVV-DVLTSYESCNITSYDNLFRTPLHWAALLGtfgRHAQIVHLLLERNKSGTIpsdsqGATPLHyAAQSNFA 306
Cdd:TIGR00870   24 AAERGDLASVyRDLEEPKKLNINCPDRLGRSALFVAAIEN---ENLELTELLLNLSCRGAV-----GDTLLH-AISLEYV 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  307 ETVKVFLQHPsvkDDSDLEGRTSFMwaagkgnddvlrtmlslksDIDINMSDKYGG-TALHAAALSGHVSTVKLLLDNDA 385
Cdd:TIGR00870   95 DAVEAILLHL---LAAFRKSGPLEL-------------------ANDQYTSEFTPGiTALHLAAHRQNYEIVKLLLERGA 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  386 QVDA------------TDVMKHT--PL-FRACeMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALggNAD--------V 442
Cdd:TIGR00870  153 SVPAracgdffvksqgVDSFYHGesPLnAAAC-LGSPSIVALLSEDPADILTADSLGNTLLHLLVM--ENEfkaeyeelS 229

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907154400  443 CQI-------------LIENKINPNvqdYAGRTPLQCAAYGGYINCMAVLME 481
Cdd:TIGR00870  230 CQMynfalslldklrdSKELEVILN---HQGLTPLKLAAKEGRIVLFRLKLA 278
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 492-520 6.82e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 6.82e-04
                            10        20
                    ....*....|....*....|....*....
gi 1907154400   492 EGRTALHWSCNNGYLDAIKLLLDFAAFPN 520
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
Ank_5 pfam13857
Ankyrin repeats (many copies);
320-368 7.47e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 7.47e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1907154400  320 DDSDLEGRTSFMWAAGKGNDDVLRTMLslKSDIDINMSDKYGGTALHAA 368
Cdd:pfam13857   10 NRLDGEGYTPLHVAAKYGALEIVRVLL--AYGVDLNLKDEEGLTALDLA 56
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 426-457 1.03e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 1.03e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907154400  426 DGHSLLHWAAL-GGNADVCQILIENKINPNVQD 457
Cdd:pfam00023    1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 426-455 1.14e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 37.24  E-value: 1.14e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907154400  426 DGHSLLHWAALGGNADVCQILIENKINPNV 455
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 460-491 1.24e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 1.24e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907154400  460 GRTPLQCAAY-GGYINCMAVLMENNADPNIQDK 491
Cdd:pfam00023    2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 460-488 1.29e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 1.29e-03
                            10        20
                    ....*....|....*....|....*....
gi 1907154400   460 GRTPLQCAAYGGYINCMAVLMENNADPNI 488
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 363-389 2.24e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 2.24e-03
                            10        20
                    ....*....|....*....|....*..
gi 1907154400   363 TALHAAALSGHVSTVKLLLDNDAQVDA 389
Cdd:smart00248    4 TPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 326-501 2.27e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 41.79  E-value: 2.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  326 GRTSFMWAAGKGNDDVLRTML----------SLKSDIDINMSDKY--GGTALHAAALSGHVSTVKLLLDNDAQVDAT--- 390
Cdd:cd21882     26 GKTCLHKAALNLNDGVNEAIMllleaapdsgNPKELVNAPCTDEFyqGQTALHIAIENRNLNLVRLLVENGADVSARatg 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  391 DVMKHTPL-----------FRACeMGHRDVIQTLIKGGARV-DLVDQD--GHSLLHWAALGGN------ADVCQ-----I 445
Cdd:cd21882    106 RFFRKSPGnlfyfgelplsLAAC-TNQEEIVRLLLENGAQPaALEAQDslGNTVLHALVLQADntpensAFVCQmynllL 184

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907154400  446 LIENKINPNVQ-----DYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEgRTALHWSC 501
Cdd:cd21882    185 SYGAHLDPTQQleeipNHQGLTPLKLAAVEGKIVMFQHILQREFSGPYQPLS-RKFTEWTY 244
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 47-76 2.31e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.47  E-value: 2.31e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907154400   47 FGRTPLMYCVLADRVDCADALLKAGADVNK 76
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
151-199 2.32e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.25  E-value: 2.32e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1907154400  151 TALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVH 199
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLK 51
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 148-175 2.40e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 2.40e-03
                            10        20
                    ....*....|....*....|....*...
gi 1907154400   148 NKQTALHWSAYYNNPEHAKLLIKHDSNI 175
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 559-809 2.64e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 41.81  E-value: 2.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  559 QDIAAFKI---QAVYKGYKVRKAFRDRKNLLMKH-EQLRKDAAAKKREEENKRKEAEQQKGQLDTDPPRSHCSSSAPVLP 634
Cdd:PRK12678    21 GGLAGMKLpelRALAKQLGIKGTSGMRKGELIAAiKEARGGGAAAAAATPAAPAAAARRAARAAAAARQAEQPAAEAAAA 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  635 CPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCP----GRASQGDSSIDLQGTASRKPSETPIEHCRGPSACV 710
Cdd:PRK12678   101 KAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAARRGAarkaGEGGEQPATEARADAAERTEEEERDERRRRGDRED 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  711 HPRSWEGGNSSKNQGTSSvEKRRGETNGKHRRCEEGPSSARQplctGSGRPAEKGEDSSPAVASASQQDHPRKPNKRQDR 790
Cdd:PRK12678   181 RQAEAERGERGRREERGR-DGDDRDRRDRREQGDRREERGRR----DGGDRRGRRRRRDRRDARGDDNREDRGDRDGDDG 255

                          250
                   ....*....|....*....
gi 1907154400  791 AARPRGASQKRRThqlRDR 809
Cdd:PRK12678   256 EGRGGRRGRRFRD---RDR 271
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 150-349 2.69e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.61  E-value: 2.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  150 QTALHWSAYYNNP-EHAKLLIKHDSNIgipdVEGKIPLHWAA-NHKDpsAVHTVRCILDAAPTES----LLNWQD----Y 219
Cdd:TIGR00870   53 RSALFVAAIENENlELTELLLNLSCRG----AVGDTLLHAISlEYVD--AVEAILLHLLAAFRKSgpleLANDQYtsefT 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  220 EGRTPLHFAVADGNLTVVDVL------TSYES----CNITSYDNLF---RTPLHWAALLGTfgrhAQIVHLLLErNKSGT 286
Cdd:TIGR00870  127 PGITALHLAAHRQNYEIVKLLlergasVPARAcgdfFVKSQGVDSFyhgESPLNAAACLGS----PSIVALLSE-DPADI 201

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907154400  287 IPSDSQGATPLHYAAQSN--------FAETVKVF-LQHPSVKDDS-DLE------GRTSFMWAAGKGNDDVLRTMLSLK 349
Cdd:TIGR00870  202 LTADSLGNTLLHLLVMENefkaeyeeLSCQMYNFaLSLLDKLRDSkELEvilnhqGLTPLKLAAKEGRIVLFRLKLAIK 280
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 642-885 3.00e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 3.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  642 EASKQDATPSKQPPASHTVQSPDPeHSRPPGRCPGRASQGDSSIDLQGTASRKPSETPIEHCRGPSACVHPRsweggNSS 721
Cdd:PHA03307    12 EAAAEGGEFFPRPPATPGDAADDL-LSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPAN-----ESR 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  722 KNQGTSSVEKRRGETNGKHRRCEEGPSSARQPLCTGSgrPAEKGEDSSPAVASASQQDHPRKPNKRQDRAARPRGASQKR 801
Cdd:PHA03307    86 STPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPP--PASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  802 RTHQlrdrcSPAGSSRPGSAKGEVACADQS---------SLHRHTPRSKVTQDKLIGGVSSGLPLSTEASRSGCKQLYED 872
Cdd:PHA03307   164 SDAA-----SSRQAALPLSSPEETARAPSSppaepppstPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSD 238

                          250
                   ....*....|...
gi 1907154400  873 ICASPETGVAHGP 885
Cdd:PHA03307   239 SSSSESSGCGWGP 251
Ank_4 pfam13637
Ankyrin repeats (many copies);
185-240 3.17e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 3.17e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907154400  185 PLHWAANHKDPSAVHtvRCILDAAPteslLNWQDYEGRTPLHFAVADGNLTVVDVL 240
Cdd:pfam13637    4 ALHAAAASGHLELLR--LLLEKGAD----INAVDGNGETALHFAASNGNVEVLKLL 53
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 360-389 3.23e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 3.23e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907154400  360 YGGTALHAAALSGHVSTVKLLLDNDAQVDA 389
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 82-106 3.32e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 3.32e-03
                            10        20
                    ....*....|....*....|....*
gi 1907154400    82 RTALHLAAQKGNYRFMKLLLTRRAN 106
Cdd:smart00248    3 RTPLHLAAENGNLEVVKLLLDKGAD 27
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 409-585 3.33e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.59  E-value: 3.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  409 VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNI 488
Cdd:PHA02876   160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINK 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400  489 QDkegrTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGER-HEVIQFMLEHGAlsiaaiqDIAAFKIQ 567
Cdd:PHA02876   240 ND----LSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKN--TPLHHASQAPSlSRLVPKLLERGA-------DVNAKNIK 306

                          170
                   ....*....|....*...
gi 1907154400  568 AVYKGYKVRKAFRDRKNL 585
Cdd:PHA02876   307 GETPLYLMAKNGYDTENI 324
Ank_4 pfam13637
Ankyrin repeats (many copies);
114-169 3.61e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 3.61e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907154400  114 EMTPLHLSTRHRSPKCLALLLKFMAPgeVDTQDKNKQTALHWSAYYNNPEHAKLLI 169
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGAD--INAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
213-262 4.02e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.56  E-value: 4.02e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907154400  213 LLNWQDYEGRTPLHFAVADGNLTVVDVLTSYEsCNITSYDNLFRTPLHWA 262
Cdd:pfam13857    8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYG-VDLNLKDEEGLTALDLA 56
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 45-106 4.88e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.80  E-value: 4.88e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907154400   45 DRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRAN 106
Cdd:PHA03100   189 DVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 55-135 5.17e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.65  E-value: 5.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154400   55 CVLADRVDCADA--LLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLAL 132
Cdd:PTZ00322    87 CQLAASGDAVGAriLLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                   ...
gi 1907154400  133 LLK 135
Cdd:PTZ00322   167 LSR 169
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 50-123 6.49e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 39.97  E-value: 6.49e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907154400   50 TPLMYCVLADRVDCADALLKAGADVNK-TDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTR 123
Cdd:PHA02884    72 NPLIYAIDCDNDDAAKLLIRYGADVNRyAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELALM 146
C11orf65 cd21090
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 ...
 918-964 6.67e-03

chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 (C11orf65) is an uncharacterized protein that may be associated with potential sensitivity to metformin in type 2 diabetes (diabetes mellitus) patients without cancer.


Pssm-ID: 411042  Cd Length: 260  Bit Score: 39.61  E-value: 6.67e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907154400  918 KNKAAAVIQRAWRSY---QLRKHLSRLLHLKQLG-AREVLRCTQVCTALLL 964
Cdd:cd21090      4 REEAARIIQRAWRRHidvQVFRYYKDLINFRGQGdPRLMLKCINPKEAELL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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