|
Name |
Accession |
Description |
Interval |
E-value |
| FBG |
smart00186 |
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ... |
975-1184 |
4.03e-120 |
|
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.
:
Pssm-ID: 214548 [Multi-domain] Cd Length: 212 Bit Score: 369.68 E-value: 4.03e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 975 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1054
Cdd:smart00186 1 LPRDCSDVLQNGGKTSGLYTIYPDGS-SRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 1055 NIHRITAQGRYELRVDMRD-GQEAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGD-SLSYHQGRPFSTEDRDNDVAVTNCA 1132
Cdd:smart00186 80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1907068254 1133 MSYKGAWWYKNCHRTNLNGKYG-ESRHSQGINWYHWKGHEFSIPFVEMKMRPY 1184
Cdd:smart00186 160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
407-597 |
1.31e-17 |
|
Fibronectin type 3 domain [General function prediction only];
:
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 88.14 E-value: 1.31e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 407 PGSRYEVSISAVRGTNESEASS----TQFTTEIDAPKNLRVGSRTATSLDLEWD-NSEAEAQEYKVVYSTLAGEQYHEvl 481
Cdd:COG3401 201 PGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTK-- 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 482 vpkgIGPTTKTTLTD--LVPGTEYGVGISAVMN----SKQSIPATMNARTEL-DSPRDLMVTASSETSISLIWTKASGP- 553
Cdd:COG3401 279 ----VATVTTTSYTDtgLTNGTTYYYRVTAVDAagneSAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSDAd 354
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1907068254 554 IDHYRIT-FTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITA 597
Cdd:COG3401 355 VTGYNVYrSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
706-785 |
7.40e-14 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 68.21 E-value: 7.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 706 DPPKNITISNVTKDSLTVSWSSPV---APFDYYRVSYRPTQVGRLDSSV-VPNTVTEFAITRLYPATEYEISLNSVRGRE 781
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....
gi 1907068254 782 ESER 785
Cdd:pfam00041 81 EGPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
257-337 |
1.08e-11 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.05 E-value: 1.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 257 STPQGLQFKTITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGVIAQ-LPSDVTSFNQTGLKPGEEYIVNVVALKEQA 332
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 1907068254 333 RSPPT 337
Cdd:pfam00041 81 EGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
169-239 |
2.31e-11 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 60.89 E-value: 2.31e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907068254 169 PPEDLRVAGISDRSIELEW----DGPMAVTEYVISYQPTALGGLQLQQRVPGDWSGVTIMELEPGLTYNISVYAV 239
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
883-968 |
6.10e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 60.20 E-value: 6.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 883 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSRKELI--VDAEDTWIRLEGLSENTDYTVLLQAAQEAT 957
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 1907068254 958 RS-SLTSTVFTT 968
Cdd:cd00063 82 ESpPSESVTVTT 93
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
617-696 |
1.27e-10 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 58.97 E-value: 1.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 617 PISHLHFSHVTSSSVNITWSdPSPPADRLILNYS----PRDKEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTV 692
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWT-PPPDGNGPITGYEveyrPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....
gi 1907068254 693 TSEP 696
Cdd:pfam00041 81 EGPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
348-427 |
2.02e-10 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 58.20 E-value: 2.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 348 PTQILVRDVSDTVAFVEWTPPR---AKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNES 424
Cdd:pfam00041 3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82
|
...
gi 1907068254 425 EAS 427
Cdd:pfam00041 83 PPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
795-867 |
3.47e-07 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 48.95 E-value: 3.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 795 DSPMDLIATNITPTEALLQWKAPM---GEVENYVIVLTHfaiAGE-----TILVDGVSEEFQLVDLLPSTHYTVTMYATS 866
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRP---KNSgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77
|
.
gi 1907068254 867 G 867
Cdd:pfam00041 78 G 78
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| FBG |
smart00186 |
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ... |
975-1184 |
4.03e-120 |
|
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.
Pssm-ID: 214548 [Multi-domain] Cd Length: 212 Bit Score: 369.68 E-value: 4.03e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 975 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1054
Cdd:smart00186 1 LPRDCSDVLQNGGKTSGLYTIYPDGS-SRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 1055 NIHRITAQGRYELRVDMRD-GQEAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGD-SLSYHQGRPFSTEDRDNDVAVTNCA 1132
Cdd:smart00186 80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1907068254 1133 MSYKGAWWYKNCHRTNLNGKYG-ESRHSQGINWYHWKGHEFSIPFVEMKMRPY 1184
Cdd:smart00186 160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
|
|
| FReD |
cd00087 |
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ... |
975-1183 |
4.29e-119 |
|
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.
Pssm-ID: 238040 [Multi-domain] Cd Length: 215 Bit Score: 367.34 E-value: 4.29e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 975 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1054
Cdd:cd00087 2 LPRDCSEVLQRGGRTSGVYTIQPPGS-NEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 1055 NIHRITAQGRYELRVDMRDG-QEAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAM 1133
Cdd:cd00087 81 KIHLLTSQGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCAE 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1907068254 1134 SYKGAWWYKNCHRTNLNGKYGESRH----SQGINWYHWKGHEFSIPFVEMKMRP 1183
Cdd:cd00087 161 SYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRP 214
|
|
| Fibrinogen_C |
pfam00147 |
Fibrinogen beta and gamma chains, C-terminal globular domain; |
976-1184 |
2.29e-98 |
|
Fibrinogen beta and gamma chains, C-terminal globular domain;
Pssm-ID: 395095 [Multi-domain] Cd Length: 221 Bit Score: 311.76 E-value: 2.29e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 976 PQDCAQHLMNGDTLSGVYTIFLNGELShKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLE-DEFWLGLD 1054
Cdd:pfam00147 2 GRDCSDVYNKGAKTSGLYTIRPDGATK-PFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGND 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 1055 NIHRITAQGRYELRVDMRDGQ-EAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGD-------SLSYHQGRPFSTEDRDNDV 1126
Cdd:pfam00147 81 KIHLLTKQGPYVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDNDS 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907068254 1127 AVTNCAMSYKGAWWYKNCHRTNLNGKY--GESRHSQ-GINWYHWKGHEFSIPFVEMKMRPY 1184
Cdd:pfam00147 161 PDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
407-597 |
1.31e-17 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 88.14 E-value: 1.31e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 407 PGSRYEVSISAVRGTNESEASS----TQFTTEIDAPKNLRVGSRTATSLDLEWD-NSEAEAQEYKVVYSTLAGEQYHEvl 481
Cdd:COG3401 201 PGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTK-- 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 482 vpkgIGPTTKTTLTD--LVPGTEYGVGISAVMN----SKQSIPATMNARTEL-DSPRDLMVTASSETSISLIWTKASGP- 553
Cdd:COG3401 279 ----VATVTTTSYTDtgLTNGTTYYYRVTAVDAagneSAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSDAd 354
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1907068254 554 IDHYRIT-FTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITA 597
Cdd:COG3401 355 VTGYNVYrSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
528-607 |
1.44e-14 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 70.14 E-value: 1.44e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 528 DSPRDLMVTASSETSISLIWTKA---SGPIDHYRITFTPSSGISS--EVTVPRDRTSYTLTDLEPGAEYIISITAERGRQ 602
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 1907068254 603 QSLES 607
Cdd:pfam00041 81 EGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
706-785 |
7.40e-14 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 68.21 E-value: 7.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 706 DPPKNITISNVTKDSLTVSWSSPV---APFDYYRVSYRPTQVGRLDSSV-VPNTVTEFAITRLYPATEYEISLNSVRGRE 781
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....
gi 1907068254 782 ESER 785
Cdd:pfam00041 81 EGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
528-613 |
5.96e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 65.60 E-value: 5.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 528 DSPRDLMVTASSETSISLIWTKAS---GPIDHYRITFTP-SSGISSEVTVPR-DRTSYTLTDLEPGAEYIISITAERGRQ 602
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREkGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 1907068254 603 QSLESTVDAFT 613
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
528-604 |
1.12e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 64.56 E-value: 1.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 528 DSPRDLMVTASSETSISLIWTKAS-----GPIDHYRITFTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITAERGRQ 602
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1907068254 603 QS 604
Cdd:smart00060 82 EG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
706-784 |
2.83e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 63.67 E-value: 2.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 706 DPPKNITISNVTKDSLTVSWSSPV---APFDYYRVSYRPTQVGR-LDSSVVPNTVTEFAITRLYPATEYEISLNSVRGRE 781
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
...
gi 1907068254 782 ESE 784
Cdd:cd00063 82 ESP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
257-337 |
1.08e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.05 E-value: 1.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 257 STPQGLQFKTITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGVIAQ-LPSDVTSFNQTGLKPGEEYIVNVVALKEQA 332
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 1907068254 333 RSPPT 337
Cdd:pfam00041 81 EGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
169-239 |
2.31e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 60.89 E-value: 2.31e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907068254 169 PPEDLRVAGISDRSIELEW----DGPMAVTEYVISYQPTALGGLQLQQRVPGDWSGVTIMELEPGLTYNISVYAV 239
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
883-968 |
6.10e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 60.20 E-value: 6.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 883 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSRKELI--VDAEDTWIRLEGLSENTDYTVLLQAAQEAT 957
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 1907068254 958 RS-SLTSTVFTT 968
Cdd:cd00063 82 ESpPSESVTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
169-254 |
9.37e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 59.43 E-value: 9.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 169 PPEDLRVAGISDRSIELEWDGP----MAVTEYVISYQPTALGGLQLQQRVPGDWSGVTIMELEPGLTYNISVYAVISNIL 244
Cdd:cd00063 3 PPTNLRVTDVTSTSVTLSWTPPeddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82
|
90
....*....|
gi 1907068254 245 SLPITAKVAT 254
Cdd:cd00063 83 SPPSESVTVT 92
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
617-696 |
1.27e-10 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 58.97 E-value: 1.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 617 PISHLHFSHVTSSSVNITWSdPSPPADRLILNYS----PRDKEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTV 692
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWT-PPPDGNGPITGYEveyrPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....
gi 1907068254 693 TSEP 696
Cdd:pfam00041 81 EGPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
348-427 |
2.02e-10 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 58.20 E-value: 2.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 348 PTQILVRDVSDTVAFVEWTPPR---AKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNES 424
Cdd:pfam00041 3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82
|
...
gi 1907068254 425 EAS 427
Cdd:pfam00041 83 PPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
883-959 |
2.32e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 58.01 E-value: 2.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 883 DPPDNLTASEVTRQSALISWQPPRAA-----IENYVLTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQAAQEAT 957
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1907068254 958 RS 959
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
706-783 |
5.47e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 56.85 E-value: 5.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 706 DPPKNITISNVTKDSLTVSWSSP-----VAPFDYYRVSYRPTQVGRLDSSVVPNTvTEFAITRLYPATEYEISLNSVRGR 780
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSS-TSYTLTGLKPGTEYEFRVRAVNGA 80
|
...
gi 1907068254 781 EES 783
Cdd:smart00060 81 GEG 83
|
|
| GGGWT_bact |
NF040941 |
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ... |
979-1018 |
2.50e-09 |
|
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.
Pssm-ID: 468872 [Multi-domain] Cd Length: 46 Bit Score: 53.72 E-value: 2.50e-09
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1907068254 979 CAQ-HLMNGDTLSGVYTIFLNGELSHK-LQVYCDMTTDGGGW 1018
Cdd:NF040941 2 CWEiLQAGPSAPSGVYWIDPDGMGGLApFQVYCDMTTDGGGW 43
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
257-344 |
4.68e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 54.81 E-value: 4.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 257 STPQGLQFKTITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGV-IAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQA 332
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 1907068254 333 RSPPTSASVSTV 344
Cdd:cd00063 82 ESPPSESVTVTT 93
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
883-952 |
1.04e-08 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 53.57 E-value: 1.04e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907068254 883 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSR--KELIVDAEDTWIRLEGLSENTDYTVLLQA 952
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
168-367 |
1.12e-08 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 59.25 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 168 APPEDLRVAGISDRSIELEWDGP--MAVTEYVISYQPTALGGLQLQQRVPGdwSGVTIMELEPGLTYNISVYAVISN--- 242
Cdd:COG3401 234 SAPTGLTATADTPGSVTLSWDPVteSDATGYRVYRSNSGDGPFTKVATVTT--TSYTDTGLTNGTTYYYRVTAVDAAgne 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 243 -ILSLPITAKVATHL-STPQGLQFKTITETTVEVQWEPfsfSFDGWEISFI--PKNNEGGVIAQL--PSDVTSFNQTGLK 316
Cdd:COG3401 312 sAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTA---SSDADVTGYNvyRSTSGGGTYTKIaeTVTTTSYTDTGLT 388
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1907068254 317 PGEEYIVNVVAL----KEQARSPPTSASVSTVIDGPTQILVRDVSDTVAFVEWTP 367
Cdd:COG3401 389 PGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATA 443
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
346-433 |
2.84e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 52.50 E-value: 2.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 346 DGPTQILVRDVSDTVAFVEWTPPRAKVDFIL---LKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTN 422
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgyvVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 1907068254 423 ESEAS-STQFTT 433
Cdd:cd00063 82 ESPPSeSVTVTT 93
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
617-688 |
3.87e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 51.85 E-value: 3.87e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907068254 617 PISHLHFSHVTSSSVNITWSDPSPPADRL-ILNYSPRDKEEDM--LEVLLDATKRHAVLMGLQPATEYIVNLVAV 688
Cdd:smart00060 3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
617-703 |
6.70e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 51.34 E-value: 6.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 617 PISHLHFSHVTSSSVNITWSDPSPPADRL---ILNYSPRDKEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTVT 693
Cdd:cd00063 3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPItgyVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82
|
90
....*....|.
gi 1907068254 694 SEPI-VGSITT 703
Cdd:cd00063 83 SPPSeSVTVTT 93
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
169-239 |
1.29e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 50.31 E-value: 1.29e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907068254 169 PPEDLRVAGISDRSIELEWDGP--MAVTEYVISYQPTALGGLQLQQRVPGDWSG--VTIMELEPGLTYNISVYAV 239
Cdd:smart00060 3 PPSNLRVTDVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGSEWKEVNVTPSStsYTLTGLKPGTEYEFRVRAV 77
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
795-867 |
3.47e-07 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 48.95 E-value: 3.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 795 DSPMDLIATNITPTEALLQWKAPM---GEVENYVIVLTHfaiAGE-----TILVDGVSEEFQLVDLLPSTHYTVTMYATS 866
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRP---KNSgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77
|
.
gi 1907068254 867 G 867
Cdd:pfam00041 78 G 78
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
257-327 |
1.91e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 46.84 E-value: 1.91e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907068254 257 STPQGLQFKTITETTVEVQWEPFSFSFDGW-EISFIPKNNEGG---VIAQLPSDVTSFNQTGLKPGEEYIVNVVA 327
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
346-424 |
9.80e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 44.91 E-value: 9.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 346 DGPTQILVRDVSDTVAFVEWTPP-RAKVDFILLKYGLVGGEGGKTTFRL--QPPLSQYSVQALRPGSRYEVSISAVRGTN 422
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1907068254 423 ES 424
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
795-867 |
1.20e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 44.53 E-value: 1.20e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907068254 795 DSPMDLIATNITPTEALLQWKAP-----MGEVENYVIVLTHFAIAGETILVDGVSEEFQLVDLLPSTHYTVTMYATSG 867
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
795-876 |
5.42e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 43.25 E-value: 5.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 795 DSPMDLIATNITPTEALLQWKAP---MGEVENYVIVLT-HFAIAGETILVDGVSE-EFQLVDLLPSTHYTVTMYA----- 864
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYReKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAvnggg 81
|
90
....*....|..
gi 1907068254 865 TSGPLMSGTIAT 876
Cdd:cd00063 82 ESPPSESVTVTT 93
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| FBG |
smart00186 |
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ... |
975-1184 |
4.03e-120 |
|
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.
Pssm-ID: 214548 [Multi-domain] Cd Length: 212 Bit Score: 369.68 E-value: 4.03e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 975 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1054
Cdd:smart00186 1 LPRDCSDVLQNGGKTSGLYTIYPDGS-SRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 1055 NIHRITAQGRYELRVDMRD-GQEAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGD-SLSYHQGRPFSTEDRDNDVAVTNCA 1132
Cdd:smart00186 80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1907068254 1133 MSYKGAWWYKNCHRTNLNGKYG-ESRHSQGINWYHWKGHEFSIPFVEMKMRPY 1184
Cdd:smart00186 160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
|
|
| FReD |
cd00087 |
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ... |
975-1183 |
4.29e-119 |
|
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.
Pssm-ID: 238040 [Multi-domain] Cd Length: 215 Bit Score: 367.34 E-value: 4.29e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 975 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1054
Cdd:cd00087 2 LPRDCSEVLQRGGRTSGVYTIQPPGS-NEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 1055 NIHRITAQGRYELRVDMRDG-QEAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAM 1133
Cdd:cd00087 81 KIHLLTSQGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCAE 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1907068254 1134 SYKGAWWYKNCHRTNLNGKYGESRH----SQGINWYHWKGHEFSIPFVEMKMRP 1183
Cdd:cd00087 161 SYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRP 214
|
|
| Fibrinogen_C |
pfam00147 |
Fibrinogen beta and gamma chains, C-terminal globular domain; |
976-1184 |
2.29e-98 |
|
Fibrinogen beta and gamma chains, C-terminal globular domain;
Pssm-ID: 395095 [Multi-domain] Cd Length: 221 Bit Score: 311.76 E-value: 2.29e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 976 PQDCAQHLMNGDTLSGVYTIFLNGELShKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLE-DEFWLGLD 1054
Cdd:pfam00147 2 GRDCSDVYNKGAKTSGLYTIRPDGATK-PFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGND 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 1055 NIHRITAQGRYELRVDMRDGQ-EAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGD-------SLSYHQGRPFSTEDRDNDV 1126
Cdd:pfam00147 81 KIHLLTKQGPYVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDNDS 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907068254 1127 AVTNCAMSYKGAWWYKNCHRTNLNGKY--GESRHSQ-GINWYHWKGHEFSIPFVEMKMRPY 1184
Cdd:pfam00147 161 PDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
407-597 |
1.31e-17 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 88.14 E-value: 1.31e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 407 PGSRYEVSISAVRGTNESEASS----TQFTTEIDAPKNLRVGSRTATSLDLEWD-NSEAEAQEYKVVYSTLAGEQYHEvl 481
Cdd:COG3401 201 PGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTK-- 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 482 vpkgIGPTTKTTLTD--LVPGTEYGVGISAVMN----SKQSIPATMNARTEL-DSPRDLMVTASSETSISLIWTKASGP- 553
Cdd:COG3401 279 ----VATVTTTSYTDtgLTNGTTYYYRVTAVDAagneSAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSDAd 354
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1907068254 554 IDHYRIT-FTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITA 597
Cdd:COG3401 355 VTGYNVYrSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
528-607 |
1.44e-14 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 70.14 E-value: 1.44e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 528 DSPRDLMVTASSETSISLIWTKA---SGPIDHYRITFTPSSGISS--EVTVPRDRTSYTLTDLEPGAEYIISITAERGRQ 602
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 1907068254 603 QSLES 607
Cdd:pfam00041 81 EGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
706-785 |
7.40e-14 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 68.21 E-value: 7.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 706 DPPKNITISNVTKDSLTVSWSSPV---APFDYYRVSYRPTQVGRLDSSV-VPNTVTEFAITRLYPATEYEISLNSVRGRE 781
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....
gi 1907068254 782 ESER 785
Cdd:pfam00041 81 EGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
528-613 |
5.96e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 65.60 E-value: 5.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 528 DSPRDLMVTASSETSISLIWTKAS---GPIDHYRITFTP-SSGISSEVTVPR-DRTSYTLTDLEPGAEYIISITAERGRQ 602
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREkGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 1907068254 603 QSLESTVDAFT 613
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
528-604 |
1.12e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 64.56 E-value: 1.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 528 DSPRDLMVTASSETSISLIWTKAS-----GPIDHYRITFTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITAERGRQ 602
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1907068254 603 QS 604
Cdd:smart00060 82 EG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
706-784 |
2.83e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 63.67 E-value: 2.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 706 DPPKNITISNVTKDSLTVSWSSPV---APFDYYRVSYRPTQVGR-LDSSVVPNTVTEFAITRLYPATEYEISLNSVRGRE 781
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
...
gi 1907068254 782 ESE 784
Cdd:cd00063 82 ESP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
257-337 |
1.08e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.05 E-value: 1.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 257 STPQGLQFKTITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGVIAQ-LPSDVTSFNQTGLKPGEEYIVNVVALKEQA 332
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 1907068254 333 RSPPT 337
Cdd:pfam00041 81 EGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
169-239 |
2.31e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 60.89 E-value: 2.31e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907068254 169 PPEDLRVAGISDRSIELEW----DGPMAVTEYVISYQPTALGGLQLQQRVPGDWSGVTIMELEPGLTYNISVYAV 239
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
883-968 |
6.10e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 60.20 E-value: 6.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 883 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSRKELI--VDAEDTWIRLEGLSENTDYTVLLQAAQEAT 957
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 1907068254 958 RS-SLTSTVFTT 968
Cdd:cd00063 82 ESpPSESVTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
169-254 |
9.37e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 59.43 E-value: 9.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 169 PPEDLRVAGISDRSIELEWDGP----MAVTEYVISYQPTALGGLQLQQRVPGDWSGVTIMELEPGLTYNISVYAVISNIL 244
Cdd:cd00063 3 PPTNLRVTDVTSTSVTLSWTPPeddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82
|
90
....*....|
gi 1907068254 245 SLPITAKVAT 254
Cdd:cd00063 83 SPPSESVTVT 92
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
617-696 |
1.27e-10 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 58.97 E-value: 1.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 617 PISHLHFSHVTSSSVNITWSdPSPPADRLILNYS----PRDKEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTV 692
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWT-PPPDGNGPITGYEveyrPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....
gi 1907068254 693 TSEP 696
Cdd:pfam00041 81 EGPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
348-427 |
2.02e-10 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 58.20 E-value: 2.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 348 PTQILVRDVSDTVAFVEWTPPR---AKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNES 424
Cdd:pfam00041 3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82
|
...
gi 1907068254 425 EAS 427
Cdd:pfam00041 83 PPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
883-959 |
2.32e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 58.01 E-value: 2.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 883 DPPDNLTASEVTRQSALISWQPPRAA-----IENYVLTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQAAQEAT 957
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1907068254 958 RS 959
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
706-783 |
5.47e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 56.85 E-value: 5.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 706 DPPKNITISNVTKDSLTVSWSSP-----VAPFDYYRVSYRPTQVGRLDSSVVPNTvTEFAITRLYPATEYEISLNSVRGR 780
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSS-TSYTLTGLKPGTEYEFRVRAVNGA 80
|
...
gi 1907068254 781 EES 783
Cdd:smart00060 81 GEG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
436-520 |
2.14e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 55.58 E-value: 2.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 436 DAPKNLRVGSRTATSLDLEWD---NSEAEAQEYKVVYSTLAGEQYHEVlvPKGIGPTTKTTLTDLVPGTEYGVGISAVMN 512
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTppeDDGGPITGYVVEYREKGSGDWKEV--EVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79
|
....*...
gi 1907068254 513 SKQSIPAT 520
Cdd:cd00063 80 GGESPPSE 87
|
|
| GGGWT_bact |
NF040941 |
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ... |
979-1018 |
2.50e-09 |
|
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.
Pssm-ID: 468872 [Multi-domain] Cd Length: 46 Bit Score: 53.72 E-value: 2.50e-09
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1907068254 979 CAQ-HLMNGDTLSGVYTIFLNGELSHK-LQVYCDMTTDGGGW 1018
Cdd:NF040941 2 CWEiLQAGPSAPSGVYWIDPDGMGGLApFQVYCDMTTDGGGW 43
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
257-344 |
4.68e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 54.81 E-value: 4.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 257 STPQGLQFKTITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGV-IAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQA 332
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 1907068254 333 RSPPTSASVSTV 344
Cdd:cd00063 82 ESPPSESVTVTT 93
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
883-952 |
1.04e-08 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 53.57 E-value: 1.04e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907068254 883 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSR--KELIVDAEDTWIRLEGLSENTDYTVLLQA 952
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
168-367 |
1.12e-08 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 59.25 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 168 APPEDLRVAGISDRSIELEWDGP--MAVTEYVISYQPTALGGLQLQQRVPGdwSGVTIMELEPGLTYNISVYAVISN--- 242
Cdd:COG3401 234 SAPTGLTATADTPGSVTLSWDPVteSDATGYRVYRSNSGDGPFTKVATVTT--TSYTDTGLTNGTTYYYRVTAVDAAgne 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 243 -ILSLPITAKVATHL-STPQGLQFKTITETTVEVQWEPfsfSFDGWEISFI--PKNNEGGVIAQL--PSDVTSFNQTGLK 316
Cdd:COG3401 312 sAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTA---SSDADVTGYNvyRSTSGGGTYTKIaeTVTTTSYTDTGLT 388
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1907068254 317 PGEEYIVNVVAL----KEQARSPPTSASVSTVIDGPTQILVRDVSDTVAFVEWTP 367
Cdd:COG3401 389 PGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATA 443
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
346-433 |
2.84e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 52.50 E-value: 2.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 346 DGPTQILVRDVSDTVAFVEWTPPRAKVDFIL---LKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTN 422
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgyvVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 1907068254 423 ESEAS-STQFTT 433
Cdd:cd00063 82 ESPPSeSVTVTT 93
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
617-688 |
3.87e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 51.85 E-value: 3.87e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907068254 617 PISHLHFSHVTSSSVNITWSDPSPPADRL-ILNYSPRDKEEDM--LEVLLDATKRHAVLMGLQPATEYIVNLVAV 688
Cdd:smart00060 3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
436-510 |
6.37e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 51.08 E-value: 6.37e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907068254 436 DAPKNLRVGSRTATSLDLEWDNSEAEAQE-YKVVYSTLAGEQYHEVLVPKGIGPTTKTTLTDLVPGTEYGVGISAV 510
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITgYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
617-703 |
6.70e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 51.34 E-value: 6.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 617 PISHLHFSHVTSSSVNITWSDPSPPADRL---ILNYSPRDKEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTVT 693
Cdd:cd00063 3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPItgyVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82
|
90
....*....|.
gi 1907068254 694 SEPI-VGSITT 703
Cdd:cd00063 83 SPPSeSVTVTT 93
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
169-239 |
1.29e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 50.31 E-value: 1.29e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907068254 169 PPEDLRVAGISDRSIELEWDGP--MAVTEYVISYQPTALGGLQLQQRVPGDWSG--VTIMELEPGLTYNISVYAV 239
Cdd:smart00060 3 PPSNLRVTDVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGSEWKEVNVTPSStsYTLTGLKPGTEYEFRVRAV 77
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
436-510 |
1.59e-07 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 50.11 E-value: 1.59e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907068254 436 DAPKNLRVGSRTATSLDLEW---DNSEAEAQEYKVVYSTLAGEQY-HEVLVPkgiGPTTKTTLTDLVPGTEYGVGISAV 510
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPwNEITVP---GTTTSVTLTGLKPGTEYEVRVQAV 76
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
795-867 |
3.47e-07 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 48.95 E-value: 3.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 795 DSPMDLIATNITPTEALLQWKAPM---GEVENYVIVLTHfaiAGE-----TILVDGVSEEFQLVDLLPSTHYTVTMYATS 866
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRP---KNSgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77
|
.
gi 1907068254 867 G 867
Cdd:pfam00041 78 G 78
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
257-327 |
1.91e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 46.84 E-value: 1.91e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907068254 257 STPQGLQFKTITETTVEVQWEPFSFSFDGW-EISFIPKNNEGG---VIAQLPSDVTSFNQTGLKPGEEYIVNVVA 327
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
346-424 |
9.80e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 44.91 E-value: 9.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 346 DGPTQILVRDVSDTVAFVEWTPP-RAKVDFILLKYGLVGGEGGKTTFRL--QPPLSQYSVQALRPGSRYEVSISAVRGTN 422
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 1907068254 423 ES 424
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
795-867 |
1.20e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 44.53 E-value: 1.20e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907068254 795 DSPMDLIATNITPTEALLQWKAP-----MGEVENYVIVLTHFAIAGETILVDGVSEEFQLVDLLPSTHYTVTMYATSG 867
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
211-513 |
1.73e-05 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 48.85 E-value: 1.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 211 QQRVPGDWSGVTIMELEPGLTYNISVYAVISNILSLPITAKVATHLST----PQGLQFKTITETTVEVQWEP-FSFSFDG 285
Cdd:COG3401 184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTppsaPTGLTATADTPGSVTLSWDPvTESDATG 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 286 WEISFipKNNEGGVIAQLPS-DVTSFNQTGLKPGEEYIVNVVALKEQARSPPTSASVSTVIDG-----PTQILVRDVSDT 359
Cdd:COG3401 264 YRVYR--SNSGDGPFTKVATvTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLtppaaPSGLTATAVGSS 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 360 VAFVEWTPP-----------RAKVDFilLKYGLVGGEGGKTTFR---LQPPLS-QYSVQALRPGSRYEVSISAVRGTNES 424
Cdd:COG3401 342 SITLSWTASsdadvtgynvyRSTSGG--GTYTKIAETVTTTSYTdtgLTPGTTyYYKVTAVDAAGNESAPSEEVSATTAS 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 425 EASSTQFTTEIDAPKNLRVGSRTATSLDLEWDNSeaEAQEYKVVYSTLAGEQYHEVLVPKGIGPTTKTTLTDLVPGTEYG 504
Cdd:COG3401 420 AASGESLTASVDAVPLTDVAGATAAASAASNPGV--SAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497
|
....*....
gi 1907068254 505 VGISAVMNS 513
Cdd:COG3401 498 GGSGASSVT 506
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
795-876 |
5.42e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 43.25 E-value: 5.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 795 DSPMDLIATNITPTEALLQWKAP---MGEVENYVIVLT-HFAIAGETILVDGVSE-EFQLVDLLPSTHYTVTMYA----- 864
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYReKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAvnggg 81
|
90
....*....|..
gi 1907068254 865 TSGPLMSGTIAT 876
Cdd:cd00063 82 ESPPSESVTVTT 93
|
|
| COG4733 |
COG4733 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
335-533 |
3.61e-03 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 41.47 E-value: 3.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 335 PPTSASVSTVIDGPTQILVRDVSDTVAFVEWTPPRAKVDF-ILLKYGlvggeGGKTTFRLQPPLSQYSVQALRPGsRYEV 413
Cdd:COG4733 528 PPQWPPVNVTTSESLSVVAQGTAVTTLTVSWDAPAGAVAYeVEWRRD-----DGNWVSVPRTSGTSFEVPGIYAG-DYEV 601
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 414 SisaVRGTNESEASS-TQFTTEID---------APKNLRVGSRTaTSLDLEWDNS-EAEAQEYKVVYSTLAGEQyhEVLV 482
Cdd:COG4733 602 R---VRAINALGVSSaWAASSETTvtgktapppAPTGLTATGGL-GGITLSWSFPvDADTLRTEIRYSTTGDWA--SATV 675
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1907068254 483 PKGIGPTTKTTLTDLVPGTEYGVGISAVMNSKQSIPATMNARTELDSPRDL 533
Cdd:COG4733 676 AQALYPGNTYTLAGLKAGQTYYYRARAVDRSGNVSAWWVSGQASADAAGIL 726
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
686-968 |
4.11e-03 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 41.14 E-value: 4.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 686 VAVHGTVTSEPIVGSITTGIDPPKNITISNVTKDSLTVSWSSPVAPFDYYRVSYRPTQVG------RLDSSVVPNTVTEF 759
Cdd:COG3401 115 DEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTsataavATTSLTVTSTTLVD 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 760 AITRLYPATEYEISL---NSVRGREESERIC-TLVHTAMDSPMDLIATNITPTEALLQWKAPMGEVENYVIVLTHFAIAG 835
Cdd:COG3401 195 GGGDIEPGTTYYYRVaatDTGGESAPSNEVSvTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDG 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068254 836 ETILVDGVSE-EFQLVDLLPSTHYTVTMYA------TSGPlmSGTI-ATNFSTLLDPPDNLTASEVTRQSALISWQPPRA 907
Cdd:COG3401 275 PFTKVATVTTtSYTDTGLTNGTTYYYRVTAvdaagnESAP--SNVVsVTTDLTPPAAPSGLTATAVGSSSITLSWTASSD 352
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907068254 908 A-IENYVLTYKSTDGSRKELIVD-AEDTWIRLEGLSENTDYTVLLQAAQEATRSSLTSTVFTT 968
Cdd:COG3401 353 AdVTGYNVYRSTSGGGTYTKIAEtVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSA 415
|
|
| |
