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Conserved domains on  [gi|1907152254|ref|XP_036019237|]
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fibronectin type III domain-containing protein 3B isoform X2 [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10047016)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to fibronectin type-III domain-containing protein 3A/3B

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
522-781 2.60e-19

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 93.53  E-value: 2.60e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  522 NLKRSTQYKFRLTASNMEGKSCPSEVLVCTTSPDRPGPPTrPLIKGPVTSHGFSVKWDAPKDNGGSEilkYLLEItdGTS 601
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT-GLTATADTPGSVTLSWDPVTESDATG---YRVYR--SNS 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  602 EAGQWEVAYSGSATEYVFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSLAPGqcrPPRVL--GRPKHKGVHLEW 677
Cdd:COG3401    272 GDGPFTKVATVTTTSYTDTGLTNGTtyYYRVTA-VDAAGNESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  678 DvPASESGceVSEYSVE-MTEPENVASEVYHGP-ELECTVGNLLPGTVYRFRVRALNDGG-YGPYSDVSEITTAAGPPGQ 754
Cdd:COG3401    348 T-ASSDAD--VTGYNVYrSTSGGGTYTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE 424

                          250       260
                   ....*....|....*....|....*..
gi 1907152254  755 cRAPRVSFTPDGCVLVGWESPASPGAD 781
Cdd:COG3401    425 -SLTASVDAVPLTDVAGATAAASAASN 450
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
814-1048 9.02e-12

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 69.26  E-value: 9.02e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  814 PAAQYCCRLQAFNPAGAGPYSELVHCQTPASAPDPVSTLcvleeeppSAHPDSPSVcLVLNWEEpcNNGSEILAYNIDLG 893
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGL--------TATADTPGS-VTLSWDP--VTESDATGYRVYRS 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  894 DSC------ITVGNTTTHVMKNLLPETTYRIRIQAINEIGV-GPFSQFIKAKTRPLPPSP-PRLECAASGPQSLKLKWgD 965
Cdd:COG3401    270 NSGdgpftkVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAApSGLTATAVGSSSITLSW-T 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  966 SNSKTHAAGDMVYtlqledRNKRFISIYRG-----PSHTYKVQRLTEFTCYSFRIQAMSEAG-EGPYSETYTFSTTkSVP 1039
Cdd:COG3401    349 ASSDADVTGYNVY------RSTSGGGTYTKiaetvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTA-SAA 421


                   ....*....
gi 1907152254 1040 PTLKAPRVT 1048
Cdd:COG3401    422 SGESLTASV 430
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 463-552 1.13e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 1.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  463 PLAPRLVRAGV---TWITLQWSRPEGcSPEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNM 538
Cdd:cd00063      1 PSPPTNLRVTDvtsTSVTLSWTPPED-DGGPITGYVVEYREkGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1907152254  539 EGKSCPSEVLVCTT 552
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 283-377 7.05e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 7.05e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  283 EKPQVSNIQARAVVLSWAPPVGLSCGPHGglsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAV 361
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDGGPITG-------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1907152254  362 YNSVKGSCSEPVSFTT 377
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
999-1131 3.79e-08

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.70  E-value: 3.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  999 TYKVQRLTEFTCYSFRIQAMSEAGEGPYSETYTFsTTKSVPPTlkAP---RVTQLEGNSCEIFWETVPPMRGDpvSYVLQ 1075
Cdd:COG3401    193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTESDAT--GYRVY 267

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152254 1076 VLVGRDSEYKQVYKGEEATFQISGLQSNTDYRFRVCAcrrcVDTSQELSgAFSPSA 1131
Cdd:COG3401    268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA----VDAAGNES-APSNVV 318
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 382-455 5.13e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 5.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  382 PECPFPPKLAHRSKSSLTLQW-----------------KGKRNSGFRQC--FFGSQKHCKLTKLCPAMGYTFRLAARNDI 442
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWtppeddggpitgyvveyREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1907152254  443 GTSGYSQEVVCYT 455
Cdd:cd00063     81 GESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
522-781 2.60e-19

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 93.53  E-value: 2.60e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  522 NLKRSTQYKFRLTASNMEGKSCPSEVLVCTTSPDRPGPPTrPLIKGPVTSHGFSVKWDAPKDNGGSEilkYLLEItdGTS 601
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT-GLTATADTPGSVTLSWDPVTESDATG---YRVYR--SNS 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  602 EAGQWEVAYSGSATEYVFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSLAPGqcrPPRVL--GRPKHKGVHLEW 677
Cdd:COG3401    272 GDGPFTKVATVTTTSYTDTGLTNGTtyYYRVTA-VDAAGNESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  678 DvPASESGceVSEYSVE-MTEPENVASEVYHGP-ELECTVGNLLPGTVYRFRVRALNDGG-YGPYSDVSEITTAAGPPGQ 754
Cdd:COG3401    348 T-ASSDAD--VTGYNVYrSTSGGGTYTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE 424

                          250       260
                   ....*....|....*....|....*..
gi 1907152254  755 cRAPRVSFTPDGCVLVGWESPASPGAD 781
Cdd:COG3401    425 -SLTASVDAVPLTDVAGATAAASAASN 450
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 673-747 5.20e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.98  E-value: 5.20e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907152254  673 VHLEWDVPASESGcEVSEYSVEMTEPENVASEVY---HGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITT 747
Cdd:cd00063     17 VTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVevtPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
814-1048 9.02e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 69.26  E-value: 9.02e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  814 PAAQYCCRLQAFNPAGAGPYSELVHCQTPASAPDPVSTLcvleeeppSAHPDSPSVcLVLNWEEpcNNGSEILAYNIDLG 893
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGL--------TATADTPGS-VTLSWDP--VTESDATGYRVYRS 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  894 DSC------ITVGNTTTHVMKNLLPETTYRIRIQAINEIGV-GPFSQFIKAKTRPLPPSP-PRLECAASGPQSLKLKWgD 965
Cdd:COG3401    270 NSGdgpftkVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAApSGLTATAVGSSSITLSW-T 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  966 SNSKTHAAGDMVYtlqledRNKRFISIYRG-----PSHTYKVQRLTEFTCYSFRIQAMSEAG-EGPYSETYTFSTTkSVP 1039
Cdd:COG3401    349 ASSDADVTGYNVY------RSTSGGGTYTKiaetvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTA-SAA 421


                   ....*....
gi 1907152254 1040 PTLKAPRVT 1048
Cdd:COG3401    422 SGESLTASV 430
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 463-552 1.13e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 1.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  463 PLAPRLVRAGV---TWITLQWSRPEGcSPEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNM 538
Cdd:cd00063      1 PSPPTNLRVTDvtsTSVTLSWTPPED-DGGPITGYVVEYREkGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1907152254  539 EGKSCPSEVLVCTT 552
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 557-641 1.38e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.78  E-value: 1.38e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254   557 PGPPTRPLIKgPVTSHGFSVKWDAPK-DNGGSEILKYllEITDGTSEAGQWEVAYSGSATEYVFTHLKPGTLYKLRACCI 635
Cdd:smart00060    1 PSPPSNLRVT-DVTSTSVTLSWEPPPdDGITGYIVGY--RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 1907152254   636 STGGHS 641
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
860-932 3.59e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 3.59e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  860 PSAHPDSPSVcLVLNWEEPCNNGSEILAYNIDLGD--------SCITVGNTTTHVMKNLLPETTYRIRIQAINEIGVGPF 931
Cdd:pfam00041    6 LTVTDVTSTS-LTVSWTPPPDGNGPITGYEVEYRPknsgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84


                   .
gi 1907152254  932 S 932
Cdd:pfam00041   85 S 85
fn3 pfam00041
Fibronectin type III domain;
673-740 2.10e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 2.10e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907152254  673 VHLEWDVPASESGcEVSEYSVE---MTEPENVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS 740
Cdd:pfam00041   16 LTVSWTPPPDGNG-PITGYEVEyrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 871-939 5.69e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 5.69e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907152254  871 LVLNWEEPCNNGSEILAYNI----DLGDSCITV----GNTTTHVMKNLLPETTYRIRIQAINEIGVGPFSQFIKAKT 939
Cdd:cd00063     17 VTLSWTPPEDDGGPITGYVVeyreKGSGDWKEVevtpGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 283-377 7.05e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 7.05e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  283 EKPQVSNIQARAVVLSWAPPVGLSCGPHGglsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAV 361
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDGGPITG-------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1907152254  362 YNSVKGSCSEPVSFTT 377
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
999-1131 3.79e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.70  E-value: 3.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  999 TYKVQRLTEFTCYSFRIQAMSEAGEGPYSETYTFsTTKSVPPTlkAP---RVTQLEGNSCEIFWETVPPMRGDpvSYVLQ 1075
Cdd:COG3401    193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTESDAT--GYRVY 267

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152254 1076 VLVGRDSEYKQVYKGEEATFQISGLQSNTDYRFRVCAcrrcVDTSQELSgAFSPSA 1131
Cdd:COG3401    268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA----VDAAGNES-APSNVV 318
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 283-363 7.91e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 7.91e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254   283 EKPQVSNIQARAVVLSWAPPVglscgPHGGLSFPYSYEVALSDKGRDGKyKIIYSGEELECNLKDLRPATDYHVRVYAVY 362
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPP-----DDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    .
gi 1907152254   363 N 363
Cdd:smart00060   79 G 79
fn3 pfam00041
Fibronectin type III domain;
285-367 4.61e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 4.61e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  285 PQVSNIQARAVVLSWAPPVGLScGPhgglsfPYSYEVALS--DKGRDGKYKIIySGEELECNLKDLRPATDYHVRVYAVY 362
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGN-GP------ITGYEVEYRpkNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*
gi 1907152254  363 NSVKG 367
Cdd:pfam00041   78 GGGEG 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 846-929 4.92e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 4.92e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254   846 PDPVSTLCVLEEEPPSahpdspsvcLVLNWEEP--CNNGSEILAYNIDLGDS------CITVGNTTTHVMKNLLPETTYR 917
Cdd:smart00060    1 PSPPSNLRVTDVTSTS---------VTLSWEPPpdDGITGYIVGYRVEYREEgsewkeVNVTPSSTSYTLTGLKPGTEYE 71

                            90
                    ....*....|..
gi 1907152254   918 IRIQAINEIGVG 929
Cdd:smart00060   72 FRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1039-1112 8.24e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.26  E-value: 8.24e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152254 1039 PPTLKAPRVTQLEGNSCEIFWETVPPMRGDPVSYVLQVLVGRDSEYKQVYK--GEEATFQISGLQSNTDYRFRVCA 1112
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 460-542 9.85e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 9.85e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254   460 PQMPLAPRLVRAGVTWITLQWSRPEGCSPEE-VITYTLDIQEDENDSHFHPKyTGEDLTCTVKNLKRSTQYKFRLTASNM 538
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1907152254   539 EGKS 542
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1039-1112 1.18e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 1.18e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907152254  1039 PPTLKAPRVTQLEGNSCEIFWEtvPPMRGDPVSYVLQVLV---GRDSEYKQVYKGEEAT-FQISGLQSNTDYRFRVCA 1112
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWE--PPPDDGITGYIVGYRVeyrEEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
1039-1112 1.69e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.69e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152254 1039 PPTlkAPRVTQLEGNSCEIFWETVPPMRGDPVSYVLQVLVGRDSEYKQVY--KGEEATFQISGLQSNTDYRFRVCA 1112
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQA 75
fn3 pfam00041
Fibronectin type III domain;
465-545 1.90e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  465 APRLVRA---GVTWITLQWSRPEGCSpEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNMEG 540
Cdd:pfam00041    2 APSNLTVtdvTSTSLTVSWTPPPDGN-GPITGYEVEYRPkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1907152254  541 KSCPS 545
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 382-455 5.13e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 5.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  382 PECPFPPKLAHRSKSSLTLQW-----------------KGKRNSGFRQC--FFGSQKHCKLTKLCPAMGYTFRLAARNDI 442
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWtppeddggpitgyvveyREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1907152254  443 GTSGYSQEVVCYT 455
Cdd:cd00063     81 GESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
522-781 2.60e-19

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 93.53  E-value: 2.60e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  522 NLKRSTQYKFRLTASNMEGKSCPSEVLVCTTSPDRPGPPTrPLIKGPVTSHGFSVKWDAPKDNGGSEilkYLLEItdGTS 601
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT-GLTATADTPGSVTLSWDPVTESDATG---YRVYR--SNS 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  602 EAGQWEVAYSGSATEYVFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSLAPGqcrPPRVL--GRPKHKGVHLEW 677
Cdd:COG3401    272 GDGPFTKVATVTTTSYTDTGLTNGTtyYYRVTA-VDAAGNESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  678 DvPASESGceVSEYSVE-MTEPENVASEVYHGP-ELECTVGNLLPGTVYRFRVRALNDGG-YGPYSDVSEITTAAGPPGQ 754
Cdd:COG3401    348 T-ASSDAD--VTGYNVYrSTSGGGTYTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE 424

                          250       260
                   ....*....|....*....|....*..
gi 1907152254  755 cRAPRVSFTPDGCVLVGWESPASPGAD 781
Cdd:COG3401    425 -SLTASVDAVPLTDVAGATAAASAASN 450
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
551-927 2.10e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 87.37  E-value: 2.10e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  551 TTSPDRPGPPTRPLIKGPVTSHGFSVKWDAPKDNGGSEILKYLLEITDGTSEAGQWEVAYSGSATEYVFTHLKPGTLYKL 630
Cdd:COG3401    128 ATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYY 207

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  631 RACCISTGGHSQCSESLPVRTLSLAPGQcrPPRVLGRPK-HKGVHLEWDvPASESGceVSEYSVEMTEPENVA-SEVYHG 708
Cdd:COG3401    208 RVAATDTGGESAPSNEVSVTTPTTPPSA--PTGLTATADtPGSVTLSWD-PVTESD--ATGYRVYRSNSGDGPfTKVATV 282

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  709 PELECTVGNLLPGTVYRFRVRALN-DGGYGPYSDVSEITTAAGPPGQCRAPRVSFTPDGCVLVGWEspASPGADISEYRL 787
Cdd:COG3401    283 TTTSYTDTGLTNGTTYYYRVTAVDaAGNESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWT--ASSDADVTGYNV 360

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  788 E-WGEDEQSLELVYHGPD-TCFEMRDLLPAAQYCCRLQAFNPAG-AGPYSELVHCQTPASAPDPVSTLCVLEEEPPSAHP 864
Cdd:COG3401    361 YrSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTASVDAVPLTDVAG 440

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907152254  865 DSPSVclvlnWEEPCNNGSEILAYNIDLGDSCITVGNTTTHVMKNLLPETTYRIRIQAINEIG 927
Cdd:COG3401    441 ATAAA-----SAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVG 498
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
432-764 2.06e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 77.74  E-value: 2.06e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  432 YTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPLAPRLVRAGVTWITLQWSRPEGcspEEVITYTLDIQEDENDShFHPKY 511
Cdd:COG3401    205 YYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTE---SDATGYRVYRSNSGDGP-FTKVA 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  512 TGEDLTCTVKNLKRSTQYKFRLTASNMEG-KSCPSEVLVCTTSPDRPGPPTrPLIKGPVTSHGFSVKWDAPKDNGgseIL 590
Cdd:COG3401    281 TVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPS-GLTATAVGSSSITLSWTASSDAD---VT 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  591 KYLLEItdGTSEAGQWE-VAYSGSATEYVFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSLAPGQcRPPRVLGR 667
Cdd:COG3401    357 GYNVYR--STSGGGTYTkIAETVTTTSYTDTGLTPGTtyYYKVTA-VDAAGNESAPSEEVSATTASAASGE-SLTASVDA 432

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  668 PKHKGVHLEWDVPASESGCEVSEYSVEMTEPENVASEVYHGPELECTVGNLLPGTVYRFrVRALNDGGYGPYSDVSEITT 747
Cdd:COG3401    433 VPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSV-TTGSLVGGSGASSVTNSVSV 511

                          330
                   ....*....|....*..
gi 1907152254  748 AAGPPGQCRAPRVSFTP 764
Cdd:COG3401    512 IGASAAAAVGGAPDGTP 528
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 673-747 5.20e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.98  E-value: 5.20e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907152254  673 VHLEWDVPASESGcEVSEYSVEMTEPENVASEVY---HGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITT 747
Cdd:cd00063     17 VTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVevtPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 557-651 1.39e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 1.39e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  557 PGPPTRPLIKgPVTSHGFSVKWDAPKDNGGsEILKYLLEITDGTSEAGQWEVAYSGSATEYVFTHLKPGTLYKLRACCIS 636
Cdd:cd00063      1 PSPPTNLRVT-DVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....*
gi 1907152254  637 TGGHSQCSESLPVRT 651
Cdd:cd00063     79 GGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
814-1048 9.02e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 69.26  E-value: 9.02e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  814 PAAQYCCRLQAFNPAGAGPYSELVHCQTPASAPDPVSTLcvleeeppSAHPDSPSVcLVLNWEEpcNNGSEILAYNIDLG 893
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGL--------TATADTPGS-VTLSWDP--VTESDATGYRVYRS 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  894 DSC------ITVGNTTTHVMKNLLPETTYRIRIQAINEIGV-GPFSQFIKAKTRPLPPSP-PRLECAASGPQSLKLKWgD 965
Cdd:COG3401    270 NSGdgpftkVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAApSGLTATAVGSSSITLSW-T 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  966 SNSKTHAAGDMVYtlqledRNKRFISIYRG-----PSHTYKVQRLTEFTCYSFRIQAMSEAG-EGPYSETYTFSTTkSVP 1039
Cdd:COG3401    349 ASSDADVTGYNVY------RSTSGGGTYTKiaetvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTA-SAA 421


                   ....*....
gi 1907152254 1040 PTLKAPRVT 1048
Cdd:COG3401    422 SGESLTASV 430
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
912-1132 1.09e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.88  E-value: 1.09e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  912 PETTYRIRIQAINEIGVGPFSQFIKAKTRPLPPSPPRL-ECAASGPQSLKLKWgDSNSKTHAAGDMVYtlQLEDRNKRFI 990
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGlTATADTPGSVTLSW-DPVTESDATGYRVY--RSNSGDGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  991 SIYRGPSHTYKVQRLTEFTCYSFRIQAMSEAG-EGPYSETYTFSTTKSVPPTLKAPRVTQLEGNSCEIFWETVPPmrGDP 1069
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSD--ADV 355

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907152254 1070 VSYVLQVLVGRDSEYKQVYKGEEAT-FQISGLQSNTDYRFRVcacrRCVDTSQELSGAFSPSAA 1132
Cdd:COG3401    356 TGYNVYRSTSGGGTYTKIAETVTTTsYTDTGLTPGTTYYYKV----TAVDAAGNESAPSEEVSA 415
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 463-552 1.13e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 1.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  463 PLAPRLVRAGV---TWITLQWSRPEGcSPEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNM 538
Cdd:cd00063      1 PSPPTNLRVTDvtsTSVTLSWTPPED-DGGPITGYVVEYREkGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1907152254  539 EGKSCPSEVLVCTT 552
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 752-841 4.26e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.59  E-value: 4.26e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  752 PGQCRAPRVSFTPDGCVLVGWESPASPGADISEYRLEW---GEDEQSLELVYHGPDTCFEMRDLLPAAQYCCRLQAFNPA 828
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrekGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1907152254  829 GAGPYSELVHCQT 841
Cdd:cd00063     81 GESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 557-641 1.38e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.78  E-value: 1.38e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254   557 PGPPTRPLIKgPVTSHGFSVKWDAPK-DNGGSEILKYllEITDGTSEAGQWEVAYSGSATEYVFTHLKPGTLYKLRACCI 635
Cdd:smart00060    1 PSPPSNLRVT-DVTSTSVTLSWEPPPdDGITGYIVGY--RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 1907152254   636 STGGHS 641
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
860-932 3.59e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 3.59e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  860 PSAHPDSPSVcLVLNWEEPCNNGSEILAYNIDLGD--------SCITVGNTTTHVMKNLLPETTYRIRIQAINEIGVGPF 931
Cdd:pfam00041    6 LTVTDVTSTS-LTVSWTPPPDGNGPITGYEVEYRPknsgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84


                   .
gi 1907152254  932 S 932
Cdd:pfam00041   85 S 85
fn3 pfam00041
Fibronectin type III domain;
673-740 2.10e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 2.10e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907152254  673 VHLEWDVPASESGcEVSEYSVE---MTEPENVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS 740
Cdd:pfam00041   16 LTVSWTPPPDGNG-PITGYEVEyrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
350-620 3.75e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 60.79  E-value: 3.75e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  350 PATDYHVRVYAVYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQW---KGKRNSGFR--QCFFGSQKHCKL- 423
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWdpvTESDATGYRvyRSNSGDGPFTKVa 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  424 ---------TKLCPAMGYTFRLAARNDIGT-SGYSQEVVCYTLGNIPQMPLAPRLVRAGVTWITLQWSRPegcSPEEVIT 493
Cdd:COG3401    281 tvtttsytdTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS---SDADVTG 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  494 YTLDiQEDENDSHFHP-KYTGEDLTCTVKNLKRSTQYKFRLTASNMEG-KSCPSEVLVCTTSPDRPGPPT---RPLIKGP 568
Cdd:COG3401    358 YNVY-RSTSGGGTYTKiAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLtasVDAVPLT 436

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  569 VTSHGFSVKWDAPKDNGGSEIL--------KYLLEITDGTSEAGQWEVAYSGSATEYVFT 620
Cdd:COG3401    437 DVAGATAAASAASNPGVSAAVLadggdtgnAVPFTTTSSTVTATTTDTTTANLSVTTGSL 496
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 656-737 3.98e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 3.98e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254   656 PGQCRPPRVLGRPKHKgVHLEWDVPASE-SGCEVSEYSVEMTEPENVASEVYHGP-ELECTVGNLLPGTVYRFRVRALND 733
Cdd:smart00060    1 PSPPSNLRVTDVTSTS-VTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVNVTPsSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1907152254   734 GGYG 737
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 871-939 5.69e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 5.69e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907152254  871 LVLNWEEPCNNGSEILAYNI----DLGDSCITV----GNTTTHVMKNLLPETTYRIRIQAINEIGVGPFSQFIKAKT 939
Cdd:cd00063     17 VTLSWTPPEDDGGPITGYVVeyreKGSGDWKEVevtpGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 283-377 7.05e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 7.05e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  283 EKPQVSNIQARAVVLSWAPPVGLSCGPHGglsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAV 361
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDGGPITG-------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1907152254  362 YNSVKGSCSEPVSFTT 377
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
558-642 9.92e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.57  E-value: 9.92e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  558 GPPTRPLIKgPVTSHGFSVKWDAPKDnGGSEILKYLLEITDGTSEAGQWEVAYSGSATEYVFTHLKPGTLYKLRACCIST 637
Cdd:pfam00041    1 SAPSNLTVT-DVTSTSLTVSWTPPPD-GNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*
gi 1907152254  638 GGHSQ 642
Cdd:pfam00041   79 GGEGP 83
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
575-777 2.24e-08

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 58.80  E-value: 2.24e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  575 SVKWDAPKDNGGseilkYLLEITDGtseAGQWEVAYSGSATEYVFTHLKPGTlYKLRACCISTGGHSQCSESLPVRTLS- 653
Cdd:COG4733    555 TVSWDAPAGAVA-----YEVEWRRD---DGNWVSVPRTSGTSFEVPGIYAGD-YEVRVRAINALGVSSAWAASSETTVTg 625

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  654 -LAPgqcrPPRVLG---RPKHKGVHLEWDVPAsesGCEVSEYSVEM---TEPENVASEVYHGPELECTVGNLLPGTVYRF 726
Cdd:COG4733    626 kTAP----PPAPTGltaTGGLGGITLSWSFPV---DADTLRTEIRYsttGDWASATVAQALYPGNTYTLAGLKAGQTYYY 698

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907152254  727 RVRALNDGG-YGPYSDVSEITTAAGPPGQCRAPRVSFTPDGCVLVGWESPAS 777
Cdd:COG4733    699 RARAVDRSGnVSAWWVSGQASADAAGILDAITGQILETELGQELDAIIQNAT 750
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
999-1131 3.79e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.70  E-value: 3.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  999 TYKVQRLTEFTCYSFRIQAMSEAGEGPYSETYTFsTTKSVPPTlkAP---RVTQLEGNSCEIFWETVPPMRGDpvSYVLQ 1075
Cdd:COG3401    193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTESDAT--GYRVY 267

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152254 1076 VLVGRDSEYKQVYKGEEATFQISGLQSNTDYRFRVCAcrrcVDTSQELSgAFSPSA 1131
Cdd:COG3401    268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA----VDAAGNES-APSNVV 318
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 283-363 7.91e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 7.91e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254   283 EKPQVSNIQARAVVLSWAPPVglscgPHGGLSFPYSYEVALSDKGRDGKyKIIYSGEELECNLKDLRPATDYHVRVYAVY 362
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPP-----DDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    .
gi 1907152254   363 N 363
Cdd:smart00060   79 G 79
fn3 pfam00041
Fibronectin type III domain;
285-367 4.61e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 4.61e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  285 PQVSNIQARAVVLSWAPPVGLScGPhgglsfPYSYEVALS--DKGRDGKYKIIySGEELECNLKDLRPATDYHVRVYAVY 362
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGN-GP------ITGYEVEYRpkNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*
gi 1907152254  363 NSVKG 367
Cdd:pfam00041   78 GGGEG 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 846-929 4.92e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 4.92e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254   846 PDPVSTLCVLEEEPPSahpdspsvcLVLNWEEP--CNNGSEILAYNIDLGDS------CITVGNTTTHVMKNLLPETTYR 917
Cdd:smart00060    1 PSPPSNLRVTDVTSTS---------VTLSWEPPpdDGITGYIVGYRVEYREEgsewkeVNVTPSSTSYTLTGLKPGTEYE 71

                            90
                    ....*....|..
gi 1907152254   918 IRIQAINEIGVG 929
Cdd:smart00060   72 FRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1039-1112 8.24e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.26  E-value: 8.24e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152254 1039 PPTLKAPRVTQLEGNSCEIFWETVPPMRGDPVSYVLQVLVGRDSEYKQVYK--GEEATFQISGLQSNTDYRFRVCA 1112
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 460-542 9.85e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 9.85e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254   460 PQMPLAPRLVRAGVTWITLQWSRPEGCSPEE-VITYTLDIQEDENDSHFHPKyTGEDLTCTVKNLKRSTQYKFRLTASNM 538
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1907152254   539 EGKS 542
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 752-831 1.79e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 1.79e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254   752 PGQCRAPRVSFTPDGCVLVGWESPASPGAD--ISEYRLEWGE-DEQSLELVYHGPDTCFEMRDLLPAAQYCCRLQAFNPA 828
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 1907152254   829 GAG 831
Cdd:smart00060   81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 955-1034 7.55e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.57  E-value: 7.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  955 GPQSLKLKWgdSNSKTHAAGDMVYTLQLEDRNK---RFISIYRGPSHTYKVQRLTEFTCYSFRIQAMSEAGEGPYSETYT 1031
Cdd:cd00063     13 TSTSVTLSW--TPPEDDGGPITGYVVEYREKGSgdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVT 90


                   ...
gi 1907152254 1032 FST 1034
Cdd:cd00063     91 VTT 93
fn3 pfam00041
Fibronectin type III domain;
768-834 1.11e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.71  E-value: 1.11e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  768 VLVGWESPASPGADISEYRLEW---GEDEQSLELVYHGPDTCFEMRDLLPAAQYCCRLQAFNPAGAGPYS 834
Cdd:pfam00041   16 LTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1039-1112 1.18e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 1.18e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907152254  1039 PPTLKAPRVTQLEGNSCEIFWEtvPPMRGDPVSYVLQVLV---GRDSEYKQVYKGEEAT-FQISGLQSNTDYRFRVCA 1112
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWE--PPPDDGITGYIVGYRVeyrEEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
1039-1112 1.69e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.69e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152254 1039 PPTlkAPRVTQLEGNSCEIFWETVPPMRGDPVSYVLQVLVGRDSEYKQVY--KGEEATFQISGLQSNTDYRFRVCA 1112
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQA 75
fn3 pfam00041
Fibronectin type III domain;
465-545 1.90e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  465 APRLVRA---GVTWITLQWSRPEGCSpEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNMEG 540
Cdd:pfam00041    2 APSNLTVtdvTSTSLTVSWTPPPDGN-GPITGYEVEYRPkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1907152254  541 KSCPS 545
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 953-1024 1.76e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 38.36  E-value: 1.76e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907152254   953 ASGPQSLKLKWGDSNSKTHAAGDMVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQAMSEAGEG 1024
Cdd:smart00060   11 DVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 382-455 5.13e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 5.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152254  382 PECPFPPKLAHRSKSSLTLQW-----------------KGKRNSGFRQC--FFGSQKHCKLTKLCPAMGYTFRLAARNDI 442
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWtppeddggpitgyvveyREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1907152254  443 GTSGYSQEVVCYT 455
Cdd:cd00063     81 GESPPSESVTVTT 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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