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Conserved domains on  [gi|1907140460|ref|XP_036018182|]
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PC-esterase domain-containing protein 1A isoform X4 [Mus musculus]

Protein Classification

SGNH/GDSL hydrolase family protein( domain architecture ID 85)

SGNH/GDSL hydrolase family protein is a hydrolytic enzyme such as an esterase or lipase; may have multifunctional properties including broad substrate specificity and regiospecificity; similar to plant GDSL esterase/lipase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SGNH_hydrolase super family cl01053
SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary ...
 1-113 2.33e-69

SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid.


The actual alignment was detected with superfamily member cd01842:

Pssm-ID: 470049  Cd Length: 183  Bit Score: 213.13  E-value: 2.33e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140460   1 MESYRENLERVFVRMDQVLPDSCLLVWNLAMPLGERVTGGFLLPELQPLAVSLRQDVVEGNFYSATLAGKHCFDVLDLHF 80
Cdd:cd01842    71 MKTYRENLERLFSKLDSVLPIECLIVWNTAMPVAEEIKGGFLLPELHDLSKSLRYDVLEGNFYSATLAKCYGFDVLDLHY 150

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1907140460  81 HFRHAVRHRHRDGVHWDQHAHRHLSHLLLAHVA 113
Cdd:cd01842   151 HFRHAMQHRVRDGVHWNYVAHRRLSNLLLAHVA 183
 
Name Accession Description Interval E-value
SGNH_hydrolase_like_5 cd01842
SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The ...
 1-113 2.33e-69

SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.


Pssm-ID: 238880  Cd Length: 183  Bit Score: 213.13  E-value: 2.33e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140460   1 MESYRENLERVFVRMDQVLPDSCLLVWNLAMPLGERVTGGFLLPELQPLAVSLRQDVVEGNFYSATLAGKHCFDVLDLHF 80
Cdd:cd01842    71 MKTYRENLERLFSKLDSVLPIECLIVWNTAMPVAEEIKGGFLLPELHDLSKSLRYDVLEGNFYSATLAKCYGFDVLDLHY 150

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1907140460  81 HFRHAVRHRHRDGVHWDQHAHRHLSHLLLAHVA 113
Cdd:cd01842   151 HFRHAMQHRVRDGVHWNYVAHRRLSNLLLAHVA 183
 
Name Accession Description Interval E-value
SGNH_hydrolase_like_5 cd01842
SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The ...
 1-113 2.33e-69

SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.


Pssm-ID: 238880  Cd Length: 183  Bit Score: 213.13  E-value: 2.33e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140460   1 MESYRENLERVFVRMDQVLPDSCLLVWNLAMPLGERVTGGFLLPELQPLAVSLRQDVVEGNFYSATLAGKHCFDVLDLHF 80
Cdd:cd01842    71 MKTYRENLERLFSKLDSVLPIECLIVWNTAMPVAEEIKGGFLLPELHDLSKSLRYDVLEGNFYSATLAKCYGFDVLDLHY 150

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1907140460  81 HFRHAVRHRHRDGVHWDQHAHRHLSHLLLAHVA 113
Cdd:cd01842   151 HFRHAMQHRVRDGVHWNYVAHRRLSNLLLAHVA 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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