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Conserved domains on  [gi|1907139881|ref|XP_036018118|]
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mitogen-activated protein kinase-binding protein 1 isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
297-735 4.14e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.44  E-value: 4.14e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  297 GCADGTVRLFNPSNLHFLSTLpRPHalgtdiasiteasrlfSGGVNArypdtiaLTFDPTNQWLSCVYNDHSIYVWDVRD 376
Cdd:COG2319     96 ASADGTVRLWDLATGLLLRTL-TGH----------------TGAVRS-------VAFSPDGKTLASGSADGTVRLWDLAT 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  377 PKKVGKVYSalyHSSCVWSVevypeikdshqACLPPSSFI-TCSSDNTIRLWNTESsgvhGSTLHRnilsndlikiiyvd 455
Cdd:COG2319    152 GKLLRTLTG---HSGAVTSV-----------AFSPDGKLLaSGSDDGTVRLWDLAT----GKLLRT-------------- 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  456 gntqalldteLPGGDKAdgslmdprvgIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSkPDt 535
Cdd:COG2319    200 ----------LTGHTGA----------VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS-PD- 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  536 GlKLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFAAsDGqvrmiscgadksiyfrtaqksgegvqftrthhvv 615
Cdd:COG2319    258 G-RLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSP-DG---------------------------------- 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  616 rkttlydmdvepswKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTlikVQTDPSGIYIATSCSDKNLSIFDFSSGE 695
Cdd:COG2319    301 --------------KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDDGTVRLWDLATGE 363

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 1907139881  696 CVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 735
Cdd:COG2319    364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-428 3.28e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 124.75  E-value: 3.28e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881   84 HHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNV 163
Cdd:cd00200      2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGT--IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  164 WAWKKNIVVAS-NKVSSRVTAVSFSEDCSYFVTAG-NRHIKFWYLDDSKTSKVnatvpLLGRSGllgelrnnlftDVACG 241
Cdd:cd00200     78 WDLETGECVRTlTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTT-----LRGHTD-----------WVNSV 141

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  242 RGEKaDSTFcITSSGllcefSDR--RLldkWvELRNTDSFTTTVAH-------CISVTQEYIFCGCADGTVRLFNPSNLH 312
Cdd:cd00200    142 AFSP-DGTF-VASSS-----QDGtiKL---W-DLRTGKCVATLTGHtgevnsvAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  313 FLSTLpRPHalgtdiasiteasrlfSGGVNarypdtiALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSalyHSSC 392
Cdd:cd00200    211 CLGTL-RGH----------------ENGVN-------SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNS 263

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1907139881  393 VWSVEVYPEIKDshqaclppssFITCSSDNTIRLWN 428
Cdd:cd00200    264 VTSLAWSPDGKR----------LASGSADGTIRIWD 289
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-121 2.48e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 44.63  E-value: 2.48e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907139881   45 VLGVTVSGGRGLacdprsgLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWD 121
Cdd:cd00200    222 VNSVAFSPDGYL-------LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT--IRIWD 289
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
297-735 4.14e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.44  E-value: 4.14e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  297 GCADGTVRLFNPSNLHFLSTLpRPHalgtdiasiteasrlfSGGVNArypdtiaLTFDPTNQWLSCVYNDHSIYVWDVRD 376
Cdd:COG2319     96 ASADGTVRLWDLATGLLLRTL-TGH----------------TGAVRS-------VAFSPDGKTLASGSADGTVRLWDLAT 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  377 PKKVGKVYSalyHSSCVWSVevypeikdshqACLPPSSFI-TCSSDNTIRLWNTESsgvhGSTLHRnilsndlikiiyvd 455
Cdd:COG2319    152 GKLLRTLTG---HSGAVTSV-----------AFSPDGKLLaSGSDDGTVRLWDLAT----GKLLRT-------------- 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  456 gntqalldteLPGGDKAdgslmdprvgIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSkPDt 535
Cdd:COG2319    200 ----------LTGHTGA----------VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS-PD- 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  536 GlKLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFAAsDGqvrmiscgadksiyfrtaqksgegvqftrthhvv 615
Cdd:COG2319    258 G-RLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSP-DG---------------------------------- 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  616 rkttlydmdvepswKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTlikVQTDPSGIYIATSCSDKNLSIFDFSSGE 695
Cdd:COG2319    301 --------------KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDDGTVRLWDLATGE 363

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 1907139881  696 CVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 735
Cdd:COG2319    364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 350-732 1.41e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.91  E-value: 1.41e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  350 ALTFDPTNQWLSCVYNDHSIYVWDVRDpkkvGKVYSALY-HSSCVWSVEVYPeikDSHQaclppssFITCSSDNTIRLWN 428
Cdd:cd00200     14 CVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKgHTGPVRDVAASA---DGTY-------LASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  429 TESSGVHgSTLHrnilsndlikiiyvdgntqalldtelpgGDKADgslmdprvgIRSVCISPNGQHLASGDRMGTLRIHE 508
Cdd:cd00200     80 LETGECV-RTLT----------------------------GHTSY---------VSSVAFSPDGRILSSSSRDKTIKVWD 121

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  509 LQSLSEMLKVEAHDSEILCLEYSKPDTglkLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFaaSDGQVRMISC 588
Cdd:cd00200    122 VETGKCLTTLRGHTDWVNSVAFSPDGT---FVASSSQDGTIKLWDL-RTGKCVATLTGHTGEVNSVAF--SPDGEKLLSS 195

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  589 GADKSIyfrtaqksgegvqftrthhvvrkttlydmdvepswkytaigcqdrniRIFNISSGKQKKLFkgsQGEDGTLIKV 668
Cdd:cd00200    196 SSDGTI-----------------------------------------------KLWDLSTGKCLGTL---RGHENGVNSV 225

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907139881  669 QTDPSGiYIATSCS-DKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWR 732
Cdd:cd00200    226 AFSPDG-YLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-428 3.28e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.75  E-value: 3.28e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881   84 HHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNV 163
Cdd:cd00200      2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGT--IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  164 WAWKKNIVVAS-NKVSSRVTAVSFSEDCSYFVTAG-NRHIKFWYLDDSKTSKVnatvpLLGRSGllgelrnnlftDVACG 241
Cdd:cd00200     78 WDLETGECVRTlTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTT-----LRGHTD-----------WVNSV 141

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  242 RGEKaDSTFcITSSGllcefSDR--RLldkWvELRNTDSFTTTVAH-------CISVTQEYIFCGCADGTVRLFNPSNLH 312
Cdd:cd00200    142 AFSP-DGTF-VASSS-----QDGtiKL---W-DLRTGKCVATLTGHtgevnsvAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  313 FLSTLpRPHalgtdiasiteasrlfSGGVNarypdtiALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSalyHSSC 392
Cdd:cd00200    211 CLGTL-RGH----------------ENGVN-------SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNS 263

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1907139881  393 VWSVEVYPEIKDshqaclppssFITCSSDNTIRLWN 428
Cdd:cd00200    264 VTSLAWSPDGKR----------LASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 693-731 2.52e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 2.52e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907139881   693 SGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 731
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
694-731 7.09e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 7.09e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907139881  694 GECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 731
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-121 2.48e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.63  E-value: 2.48e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907139881   45 VLGVTVSGGRGLacdprsgLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWD 121
Cdd:cd00200    222 VNSVAFSPDGYL-------LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT--IRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 117-282 2.90e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 2.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  117 VRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGyQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTA 196
Cdd:PLN00181   557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASG-SDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAF 635

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  197 GNRHIKFWYLDDSktskvNATVPL---LGRSGLLGELRnnlFTDVACGRGEKADST-----FCITSSGL----LCEFSDR 264
Cdd:PLN00181   636 GSADHKVYYYDLR-----NPKLPLctmIGHSKTVSYVR---FVDSSTLVSSSTDNTlklwdLSMSISGInetpLHSFMGH 707

                          170
                   ....*....|....*...
gi 1907139881  265 RLLDKWVELRNTDSFTTT 282
Cdd:PLN00181   708 TNVKNFVGLSVSDGYIAT 725
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-121 3.59e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 3.59e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907139881    80 KHKQHHILNSSRKTITALAFSPDGKYLVTG-ESGHmpaVRVWD 121
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGsDDGT---IKLWD 40
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 73-151 7.01e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 42.26  E-value: 7.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881   73 VVLFNPRKHKQHHILNSSRKTItalAFSPDGKYLVTGESGHMP-AVRVWDVAERSQVAElQEHKYGVACvAFSPSAKYIV 151
Cdd:pfam08662   85 VSFFDLKGNVIHSFGEQPRNTI---FWSPFGRLVLLAGFGNLAgDIEFWDVVNKKKIAT-AEASNATLC-EWSPDGRYFL 159
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 94-150 9.70e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 43.87  E-value: 9.70e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907139881   94 ITALAFSPDGKYLVTGESG--HMPAVRVWDVAERSQVaELQEHKYGVACVAFSPSAKYI 150
Cdd:COG4946    434 ISDLAWSPDSKWLAYSKPGpnQLSQIFLYDVETGKTV-QLTDGRYDDGSPAFSPDGKYL 491
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
297-735 4.14e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.44  E-value: 4.14e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  297 GCADGTVRLFNPSNLHFLSTLpRPHalgtdiasiteasrlfSGGVNArypdtiaLTFDPTNQWLSCVYNDHSIYVWDVRD 376
Cdd:COG2319     96 ASADGTVRLWDLATGLLLRTL-TGH----------------TGAVRS-------VAFSPDGKTLASGSADGTVRLWDLAT 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  377 PKKVGKVYSalyHSSCVWSVevypeikdshqACLPPSSFI-TCSSDNTIRLWNTESsgvhGSTLHRnilsndlikiiyvd 455
Cdd:COG2319    152 GKLLRTLTG---HSGAVTSV-----------AFSPDGKLLaSGSDDGTVRLWDLAT----GKLLRT-------------- 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  456 gntqalldteLPGGDKAdgslmdprvgIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSkPDt 535
Cdd:COG2319    200 ----------LTGHTGA----------VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS-PD- 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  536 GlKLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFAAsDGqvrmiscgadksiyfrtaqksgegvqftrthhvv 615
Cdd:COG2319    258 G-RLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSP-DG---------------------------------- 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  616 rkttlydmdvepswKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTlikVQTDPSGIYIATSCSDKNLSIFDFSSGE 695
Cdd:COG2319    301 --------------KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDDGTVRLWDLATGE 363

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 1907139881  696 CVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 735
Cdd:COG2319    364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
419-755 2.99e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 2.99e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  419 SSDNTIRLWNTES-------SGVHGSTLHRNILSNDLIKIIYVDGNTQALLDTElpgGDKADGSLMDPRVGIRSVCISPN 491
Cdd:COG2319     55 AGDLTLLLLDAAAgallatlLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA---TGLLLRTLTGHTGAVRSVAFSPD 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  492 GQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSkPDtGlKLLASASRDRLIHVLDAgREYSLQQTLDEHSSSI 571
Cdd:COG2319    132 GKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS-PD-G-KLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAV 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  572 TAVKFAAsDGQvRMISCGADKSIYFRTAQkSGEGVQFTRTHHvvrkTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQ 651
Cdd:COG2319    208 RSVAFSP-DGK-LLASGSADGTVRLWDLA-TGKLLRTLTGHS----GSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL 280

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  652 KKLFKgsqGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 731
Cdd:COG2319    281 LRTLT---GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357

                          330       340
                   ....*....|....*....|....
gi 1907139881  732 RLSSemtismRQRLAELRQRQRGI 755
Cdd:COG2319    358 DLAT------GELLRTLTGHTGAV 375
WD40 COG2319
WD40 repeat [General function prediction only];
16-511 3.74e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 3.74e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881   16 LLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGVTVSGGRGLACDPRSG-LVAYPAGCVVVLFNPRKHKQHHILNSSRKTI 94
Cdd:COG2319     44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRlLASASADGTVRLWDLATGLLLRTLTGHTGAV 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881   95 TALAFSPDGKYLVTGESGHmpAVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVWAWKKNIVVAS 174
Cdd:COG2319    124 RSVAFSPDGKTLASGSADG--TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRLWDLATGKLLRT 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  175 -NKVSSRVTAVSFSEDCSYFVTAG-NRHIKFWyldDSKTSKVNATVPllGRSGLLgelrnnlfTDVAcgrgekadstfci 252
Cdd:COG2319    200 lTGHTGAVRSVAFSPDGKLLASGSaDGTVRLW---DLATGKLLRTLT--GHSGSV--------RSVA------------- 253

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  253 tssgllceFS-DRRLLdkwvelrntdsftttvahcisVTqeyifcGCADGTVRLFNPSNLHFLSTLPRPhalgtdiasit 331
Cdd:COG2319    254 --------FSpDGRLL---------------------AS------GSADGTVRLWDLATGELLRTLTGH----------- 287

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  332 easrlfSGGVNarypdtiALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVgKVYSAlyHSSCVWSVEVYPeikDSHQaclp 411
Cdd:COG2319    288 ------SGGVN-------SVAFSPDGKLLASGSDDGTVRLWDLATGKLL-RTLTG--HTGAVRSVAFSP---DGKT---- 344

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  412 pssFITCSSDNTIRLWNTESSGvhgstlhrnilsndlikiiyvdgntqalLDTELPGGDKAdgslmdprvgIRSVCISPN 491
Cdd:COG2319    345 ---LASGSDDGTVRLWDLATGE----------------------------LLRTLTGHTGA----------VTSVAFSPD 383

                          490       500
                   ....*....|....*....|
gi 1907139881  492 GQHLASGDRMGTLRIHELQS 511
Cdd:COG2319    384 GRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
25-554 5.29e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.11  E-value: 5.29e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881   25 RRSKAGNRREDLSSKVTLEKVLGVTVSGGRGLACDPRSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGK 104
Cdd:COG2319     12 ASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  105 YLVTGesGHMPAVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHdmIVNVWAWKKNIVVAS-NKVSSRVTA 183
Cdd:COG2319     92 LLASA--SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG--TVRLWDLATGKLLRTlTGHSGAVTS 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  184 VSFSEDCSYFVTAG-NRHIKFWYLDDSKTSKVnatvpLLGRSGLLgelrnnlfTDVAcgrgekadstfcitssgllceFS 262
Cdd:COG2319    168 VAFSPDGKLLASGSdDGTVRLWDLATGKLLRT-----LTGHTGAV--------RSVA---------------------FS 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  263 -DRRLLdkwvelrntdsftttvahcisvtqeyiFCGCADGTVRLFNPSNLHFLSTLPRPhalgtdiasiteasrlfSGGV 341
Cdd:COG2319    214 pDGKLL---------------------------ASGSADGTVRLWDLATGKLLRTLTGH-----------------SGSV 249

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  342 NarypdtiALTFDPTNQWLSCVYNDHSIYVWDVRDPKkvgKVYSALYHSSCVWSVEVYPeikDSHQaclppssFITCSSD 421
Cdd:COG2319    250 R-------SVAFSPDGRLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFSP---DGKL-------LASGSDD 309

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  422 NTIRLWNTESsgvhGSTLHrnilsndlikiiyvdgntqalldtelpggdkadgSLMDPRVGIRSVCISPNGQHLASGDRM 501
Cdd:COG2319    310 GTVRLWDLAT----GKLLR----------------------------------TLTGHTGAVRSVAFSPDGKTLASGSDD 351

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907139881  502 GTLRIHELQSLSEMLKVEAHDSEILCLEYSkPDtGlKLLASASRDRLIHVLDA 554
Cdd:COG2319    352 GTVRLWDLATGELLRTLTGHTGAVTSVAFS-PD-G-RTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
83-594 8.19e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.65  E-value: 8.19e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881   83 QHHILNSSRKTITALAFSPDGKYLVTGESGHmpAVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVN 162
Cdd:COG2319     28 LLLLLLGLAAAVASLAASPDGARLAAGAGDL--TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA--DGTVR 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  163 VWAWK-KNIVVASNKVSSRVTAVSFSEDCSYFVTAGNRH-IKFWyldDSKTSKVNATvpLLGRSGLLgelrnnlfTDVAc 240
Cdd:COG2319    104 LWDLAtGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGtVRLW---DLATGKLLRT--LTGHSGAV--------TSVA- 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  241 grgekadstfcitssgllceFS-DRRLLdkwvelrntdsftttvahcisVTqeyifcGCADGTVRLFNPSNLHFLSTLPR 319
Cdd:COG2319    170 --------------------FSpDGKLL---------------------AS------GSDDGTVRLWDLATGKLLRTLTG 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  320 PhalgtdiasiteasrlfSGGVNArypdtiaLTFDPTNQWLSCVYNDHSIYVWDVRDPKKVgKVYSAlyHSSCVWSVEVY 399
Cdd:COG2319    203 H-----------------TGAVRS-------VAFSPDGKLLASGSADGTVRLWDLATGKLL-RTLTG--HSGSVRSVAFS 255

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  400 PeikDSHQaclppssFITCSSDNTIRLWNTESsgvhGSTLHRnilsndlikiiyvdgntqalldtelpggdkadgsLMDP 479
Cdd:COG2319    256 P---DGRL-------LASGSADGTVRLWDLAT----GELLRT----------------------------------LTGH 287

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  480 RVGIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSkPDTglKLLASASRDRLIHVLDAgREYS 559
Cdd:COG2319    288 SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS-PDG--KTLASGSDDGTVRLWDL-ATGE 363

                          490       500       510
                   ....*....|....*....|....*....|....*
gi 1907139881  560 LQQTLDEHSSSITAVKFAAsDGQvRMISCGADKSI 594
Cdd:COG2319    364 LLRTLTGHTGAVTSVAFSP-DGR-TLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 350-732 1.41e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.91  E-value: 1.41e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  350 ALTFDPTNQWLSCVYNDHSIYVWDVRDpkkvGKVYSALY-HSSCVWSVEVYPeikDSHQaclppssFITCSSDNTIRLWN 428
Cdd:cd00200     14 CVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKgHTGPVRDVAASA---DGTY-------LASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  429 TESSGVHgSTLHrnilsndlikiiyvdgntqalldtelpgGDKADgslmdprvgIRSVCISPNGQHLASGDRMGTLRIHE 508
Cdd:cd00200     80 LETGECV-RTLT----------------------------GHTSY---------VSSVAFSPDGRILSSSSRDKTIKVWD 121

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  509 LQSLSEMLKVEAHDSEILCLEYSKPDTglkLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFaaSDGQVRMISC 588
Cdd:cd00200    122 VETGKCLTTLRGHTDWVNSVAFSPDGT---FVASSSQDGTIKLWDL-RTGKCVATLTGHTGEVNSVAF--SPDGEKLLSS 195

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  589 GADKSIyfrtaqksgegvqftrthhvvrkttlydmdvepswkytaigcqdrniRIFNISSGKQKKLFkgsQGEDGTLIKV 668
Cdd:cd00200    196 SSDGTI-----------------------------------------------KLWDLSTGKCLGTL---RGHENGVNSV 225

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907139881  669 QTDPSGiYIATSCS-DKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWR 732
Cdd:cd00200    226 AFSPDG-YLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-428 3.28e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.75  E-value: 3.28e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881   84 HHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNV 163
Cdd:cd00200      2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGT--IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  164 WAWKKNIVVAS-NKVSSRVTAVSFSEDCSYFVTAG-NRHIKFWYLDDSKTSKVnatvpLLGRSGllgelrnnlftDVACG 241
Cdd:cd00200     78 WDLETGECVRTlTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTT-----LRGHTD-----------WVNSV 141

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  242 RGEKaDSTFcITSSGllcefSDR--RLldkWvELRNTDSFTTTVAH-------CISVTQEYIFCGCADGTVRLFNPSNLH 312
Cdd:cd00200    142 AFSP-DGTF-VASSS-----QDGtiKL---W-DLRTGKCVATLTGHtgevnsvAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  313 FLSTLpRPHalgtdiasiteasrlfSGGVNarypdtiALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSalyHSSC 392
Cdd:cd00200    211 CLGTL-RGH----------------ENGVN-------SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNS 263

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1907139881  393 VWSVEVYPEIKDshqaclppssFITCSSDNTIRLWN 428
Cdd:cd00200    264 VTSLAWSPDGKR----------LASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 482-736 1.07e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.52  E-value: 1.07e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  482 GIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSkPDTglKLLASASRDRLIHVLDAGREYSLQ 561
Cdd:cd00200     11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS-ADG--TYLASGSSDKTIRLWDLETGECVR 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  562 qTLDEHSSSITAVKFAASDgqvRMI-SCGADKSIYFRTAQkSGEGVQFTRTHhvvrKTTLYDMDVEPSWKYTAIGCQDRN 640
Cdd:cd00200     88 -TLTGHTSYVSSVAFSPDG---RILsSSSRDKTIKVWDVE-TGKCLTTLRGH----TDWVNSVAFSPDGTFVASSSQDGT 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  641 IRIFNISSGKQKKLFKGSQGEdgtLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLI 720
Cdd:cd00200    159 IKLWDLRTGKCVATLTGHTGE---VNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235

                          250
                   ....*....|....*.
gi 1907139881  721 SVSGDSCIFVWRLSSE 736
Cdd:cd00200    236 SGSEDGTIRVWDLRTG 251
WD40 COG2319
WD40 repeat [General function prediction only];
292-648 5.60e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.17  E-value: 5.60e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  292 EYIFCGCADGTVRLFNPSNLHFLSTLPRPhalgtdiasiteasrlfSGGVNArypdtiaLTFDPTNQWLSCVYNDHSIYV 371
Cdd:COG2319    133 KTLASGSADGTVRLWDLATGKLLRTLTGH-----------------SGAVTS-------VAFSPDGKLLASGSDDGTVRL 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  372 WDVRDPKKVGKVYSalyHSSCVWSVEVYPeikDSHQaclppssFITCSSDNTIRLWNTEssgvhgstlhrnilsndliki 451
Cdd:COG2319    189 WDLATGKLLRTLTG---HTGAVRSVAFSP---DGKL-------LASGSADGTVRLWDLA--------------------- 234

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  452 iyvdgnTQALLDTelpggdkadgsLMDPRVGIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYS 531
Cdd:COG2319    235 ------TGKLLRT-----------LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  532 kPDtGlKLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFAAsDGQvRMISCGADKSIYFRTAQKSGEGVQFTRT 611
Cdd:COG2319    298 -PD-G-KLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSP-DGK-TLASGSDDGTVRLWDLATGELLRTLTGH 371

                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 1907139881  612 HHVVrkttlYDMDVEPSWKYTAIGCQDRNIRIFNISS 648
Cdd:COG2319    372 TGAV-----TSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 521-739 4.97e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 4.97e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  521 HDSEILCLEYSkPDTglKLLASASRDRLIHVLDAGREySLQQTLDEHSSSITAVKFAASDGQvrMISCGADKSIYFRTAQ 600
Cdd:cd00200      8 HTGGVTCVAFS-PDG--KLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTY--LASGSSDKTIRLWDLE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  601 KSGEGVQFTrtHHvvrKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGedgTLIKVQTDPSGIYIATS 680
Cdd:cd00200     82 TGECVRTLT--GH---TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTFVASS 153

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907139881  681 CSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTI 739
Cdd:cd00200    154 SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-204 6.88e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.91  E-value: 6.88e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881   75 LFNPRKHKQHHILNSSRKTITALAFSPDG-KYLVTGESGHmpaVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSV 153
Cdd:cd00200    161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGeKLLSSSSDGT---IKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASG 237

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907139881  154 GyqHDMIVNVWAWKKNIVVAS-NKVSSRVTAVSFSEDCSYFVTAGNRH-IKFW 204
Cdd:cd00200    238 S--EDGTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGtIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-165 2.97e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 2.97e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881   75 LFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTG-ESGHmpaVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSV 153
Cdd:cd00200    203 LWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGsEDGT---IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG 279

                           90
                   ....*....|..
gi 1907139881  154 GyqHDMIVNVWA 165
Cdd:cd00200    280 S--ADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
539-735 2.89e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.33  E-value: 2.89e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  539 LLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAvkfAASDGQVRMISCGADKSIYFRTAQKSGEGVQFTRTHHVVRKT 618
Cdd:COG2319      8 ALAAASADLALALLAAALGALLLLLLGLAAAVASL---AASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  619 TlydmdVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFkgsQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVA 698
Cdd:COG2319     85 A-----FSPDGRLLASASADGTVRLWDLATGLLLRTL---TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1907139881  699 TMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 735
Cdd:COG2319    157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 73-219 2.38e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.20  E-value: 2.38e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881   73 VVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVS 152
Cdd:cd00200    117 IKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT--IKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLS 194

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  153 VGyqHDMIVNVWAWKKNIVVASNKV-SSRVTAVSFSEDcSYFVTAG--NRHIKFWyldDSKTSKVNATVP 219
Cdd:cd00200    195 SS--SDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPD-GYLLASGseDGTIRVW---DLRTGECVQTLS 258
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 693-731 2.52e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 2.52e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907139881   693 SGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 731
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
694-731 7.09e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 7.09e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907139881  694 GECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 731
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-121 2.48e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.63  E-value: 2.48e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907139881   45 VLGVTVSGGRGLacdprsgLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWD 121
Cdd:cd00200    222 VNSVAFSPDGYL-------LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT--IRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 117-282 2.90e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 2.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  117 VRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGyQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTA 196
Cdd:PLN00181   557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASG-SDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAF 635

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881  197 GNRHIKFWYLDDSktskvNATVPL---LGRSGLLGELRnnlFTDVACGRGEKADST-----FCITSSGL----LCEFSDR 264
Cdd:PLN00181   636 GSADHKVYYYDLR-----NPKLPLctmIGHSKTVSYVR---FVDSSTLVSSSTDNTlklwdLSMSISGInetpLHSFMGH 707

                          170
                   ....*....|....*...
gi 1907139881  265 RLLDKWVELRNTDSFTTT 282
Cdd:PLN00181   708 TNVKNFVGLSVSDGYIAT 725
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-121 3.59e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 3.59e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907139881    80 KHKQHHILNSSRKTITALAFSPDGKYLVTG-ESGHmpaVRVWD 121
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGsDDGT---IKLWD 40
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 73-151 7.01e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 42.26  E-value: 7.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139881   73 VVLFNPRKHKQHHILNSSRKTItalAFSPDGKYLVTGESGHMP-AVRVWDVAERSQVAElQEHKYGVACvAFSPSAKYIV 151
Cdd:pfam08662   85 VSFFDLKGNVIHSFGEQPRNTI---FWSPFGRLVLLAGFGNLAgDIEFWDVVNKKKIAT-AEASNATLC-EWSPDGRYFL 159
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 125-164 7.66e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 7.66e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907139881   125 RSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVW 164
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSD--DGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 696-736 9.69e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 9.69e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907139881  696 CVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSE 736
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG 41
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 94-150 9.70e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 43.87  E-value: 9.70e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907139881   94 ITALAFSPDGKYLVTGESG--HMPAVRVWDVAERSQVaELQEHKYGVACVAFSPSAKYI 150
Cdd:COG4946    434 ISDLAWSPDSKWLAYSKPGpnQLSQIFLYDVETGKTV-QLTDGRYDDGSPAFSPDGKYL 491
WD40 pfam00400
WD domain, G-beta repeat;
82-121 2.06e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 2.06e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907139881   82 KQHHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWD 121
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGT--VKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
125-164 6.39e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 6.39e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907139881  125 RSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVW 164
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSD--DGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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