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Conserved domains on  [gi|1907118306|ref|XP_036015883|]
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target of Nesh-SH3 isoform X11 [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10440918)

fibronectin type III (FN3) domain-containing protein similar to human Target of Nesh-SH3 (Tarsh) and Drosophila melanogaster cytokine receptor (protein domeless)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 507-889 3.82e-12

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 71.89  E-value: 3.82e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  507 PSTPKRQSTPKPPRVKPAPEPETRPS--AQTTKAPRKTKKPGHHRLRRPKTTR-SPEVPKSKPALEPATVTPEILVPKIV 583
Cdd:PHA03247  2553 PPLPPAAPPAAPDRSVPPPRPAPRPSepAVTSRARRPDAPPQSARPRAPVDDRgDPRGPAPPSPLPPDTHAPDPPPPSPS 2632

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  584 PKPPQ----KPKATRRPEVPQVKPAHEPVTFGSEAPALAIVTTTDIEPVITRTKA------SVTTLAPKPPRPRTHRQRT 653
Cdd:PHA03247  2633 PAANEpdphPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAarptvgSLTSLADPPPPPPTPEPAP 2712

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  654 KYKTTQSPKIP-------HSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPfIITEAPGTTL 726
Cdd:PHA03247  2713 HALVSATPLPPgpaaarqASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASL 2791

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  727 VPKLPQQPDYPHPKPKT--------TRSPAASPTELVPTPV-------------FEPVTPL-----------KEDPVTTI 774
Cdd:PHA03247  2792 SESRESLPSPWDPADPPaavlapaaALPPAASPAGPLPPPTsaqptapppppgpPPPSLPLggsvapggdvrRRPPSRSP 2871

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  775 ASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETKTVPAVVLEPVTLRPEVQVTTLAPQKTQKKHRPSPKPKPVPSPE 854
Cdd:PHA03247  2872 AAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG 2951

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 1907118306  855 VTESKPVLPRVREPVTLRTETWVT------------TKAPKTPKRTR 889
Cdd:PHA03247  2952 AGEPSGAVPQPWLGALVPGRVAVPrfrvpqpapsreAPASSTPPLTG 2998
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1375-1466 3.02e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 3.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1375 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 1452
Cdd:cd00063      2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1907118306 1453 LGEGPASNTVAFST 1466
Cdd:cd00063     80 GGESPPSESVTVTT 93
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 954-1397 7.22e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 7.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  954 RTRRPHPRPK-TTASTGVSESKSAPTELQSLVLKPVTSPSLEIIQSQSVSddlelvAFSTESPQKTIAPR----QTTSMP 1028
Cdd:PHA03247  2585 RARRPDAPPQsARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPA------ANEPDPHPPPTVPPperpRDDPAP 2658

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1029 PKLKTPH-SRMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSVPKDERLSLKPDPEVTHSETVLPPVTF--RVEPPKTTIA 1105
Cdd:PHA03247  2659 GRVSRPRrARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAaaRQASPALPAA 2738

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1106 PLeTRGIPLIPVI--SPRPSQEELQTAMEETDQSTQELFTTKIPRTTELAKTTQAPHRlhTAPVRPRIPGrPHGRPALNK 1183
Cdd:PHA03247  2739 PA-PPAVPAGPATpgGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESR--ESLPSPWDPA-DPPAAVLAP 2814

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1184 TTTRPDKTKPRGTSHKNGvgTGTKQAPKPPSPGRNASVDSHATRKPGSvSGTRRPPiphrhSSTRPVSPERRPLPPNNVT 1263
Cdd:PHA03247  2815 AAALPPAASPAGPLPPPT--SAQPTAPPPPPGPPPPSLPLGGSVAPGG-DVRRRPP-----SRSPAAKPAAPARPPVRRL 2886

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1264 GKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPTKETDPLGKPRFIGPHvryiP 1343
Cdd:PHA03247  2887 ARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQ----P 2962

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907118306 1344 KPENKPCSITDSVRRFPTEEATEGNATSPPQNPPTNLTVVTVEGCPSFVILDWE 1397
Cdd:PHA03247  2963 WLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEE 3016
fn3 pfam00041
Fibronectin type III domain;
116-195 1.89e-04

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.63  E-value: 1.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  116 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPSD-RFYTIRYREKDKEKKWIFQLCPATET--IVENLKPNTVYEF 192
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                   ...
gi 1907118306  193 GVK 195
Cdd:pfam00041   72 RVQ 74
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 507-889 3.82e-12

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 71.89  E-value: 3.82e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  507 PSTPKRQSTPKPPRVKPAPEPETRPS--AQTTKAPRKTKKPGHHRLRRPKTTR-SPEVPKSKPALEPATVTPEILVPKIV 583
Cdd:PHA03247  2553 PPLPPAAPPAAPDRSVPPPRPAPRPSepAVTSRARRPDAPPQSARPRAPVDDRgDPRGPAPPSPLPPDTHAPDPPPPSPS 2632

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  584 PKPPQ----KPKATRRPEVPQVKPAHEPVTFGSEAPALAIVTTTDIEPVITRTKA------SVTTLAPKPPRPRTHRQRT 653
Cdd:PHA03247  2633 PAANEpdphPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAarptvgSLTSLADPPPPPPTPEPAP 2712

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  654 KYKTTQSPKIP-------HSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPfIITEAPGTTL 726
Cdd:PHA03247  2713 HALVSATPLPPgpaaarqASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASL 2791

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  727 VPKLPQQPDYPHPKPKT--------TRSPAASPTELVPTPV-------------FEPVTPL-----------KEDPVTTI 774
Cdd:PHA03247  2792 SESRESLPSPWDPADPPaavlapaaALPPAASPAGPLPPPTsaqptapppppgpPPPSLPLggsvapggdvrRRPPSRSP 2871

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  775 ASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETKTVPAVVLEPVTLRPEVQVTTLAPQKTQKKHRPSPKPKPVPSPE 854
Cdd:PHA03247  2872 AAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG 2951

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 1907118306  855 VTESKPVLPRVREPVTLRTETWVT------------TKAPKTPKRTR 889
Cdd:PHA03247  2952 AGEPSGAVPQPWLGALVPGRVAVPrfrvpqpapsreAPASSTPPLTG 2998
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1375-1466 3.02e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 3.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1375 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 1452
Cdd:cd00063      2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1907118306 1453 LGEGPASNTVAFST 1466
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1376-1456 9.14e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 9.14e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  1376 PPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV-ISRENGSFSGKNKSIQITNQTFS-TVENLKPDTSYEFQVKPKNPL 1453
Cdd:smart00060    3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSyTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 1907118306  1454 GEG 1456
Cdd:smart00060   81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
1376-1459 1.21e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.79  E-value: 1.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1376 PPTNLTVVTVEgcPSFVILDWEKP--LNDTVTEYEVISRENGSFSGKNkSIQITNQTFS-TVENLKPDTSYEFQVKPKNP 1452
Cdd:pfam00041    2 APSNLTVTDVT--STSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWN-EITVPGTTTSvTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 1907118306 1453 LGEGPAS 1459
Cdd:pfam00041   79 GGEGPPS 85
PHA03247 PHA03247
large tegument protein UL36; Provisional
 954-1397 7.22e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 7.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  954 RTRRPHPRPK-TTASTGVSESKSAPTELQSLVLKPVTSPSLEIIQSQSVSddlelvAFSTESPQKTIAPR----QTTSMP 1028
Cdd:PHA03247  2585 RARRPDAPPQsARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPA------ANEPDPHPPPTVPPperpRDDPAP 2658

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1029 PKLKTPH-SRMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSVPKDERLSLKPDPEVTHSETVLPPVTF--RVEPPKTTIA 1105
Cdd:PHA03247  2659 GRVSRPRrARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAaaRQASPALPAA 2738

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1106 PLeTRGIPLIPVI--SPRPSQEELQTAMEETDQSTQELFTTKIPRTTELAKTTQAPHRlhTAPVRPRIPGrPHGRPALNK 1183
Cdd:PHA03247  2739 PA-PPAVPAGPATpgGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESR--ESLPSPWDPA-DPPAAVLAP 2814

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1184 TTTRPDKTKPRGTSHKNGvgTGTKQAPKPPSPGRNASVDSHATRKPGSvSGTRRPPiphrhSSTRPVSPERRPLPPNNVT 1263
Cdd:PHA03247  2815 AAALPPAASPAGPLPPPT--SAQPTAPPPPPGPPPPSLPLGGSVAPGG-DVRRRPP-----SRSPAAKPAAPARPPVRRL 2886

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1264 GKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPTKETDPLGKPRFIGPHvryiP 1343
Cdd:PHA03247  2887 ARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQ----P 2962

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907118306 1344 KPENKPCSITDSVRRFPTEEATEGNATSPPQNPPTNLTVVTVEGCPSFVILDWE 1397
Cdd:PHA03247  2963 WLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEE 3016
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 384-758 9.97e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.07  E-value: 9.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  384 PEFPEAKTAFPLEKPRGSWASSEEPWVVPGAKTSEDSRVVQPQTATYDVISSSTTSDETEIEIHTATRDPILDSV----- 458
Cdd:pfam03154  171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPhpplq 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  459 -------PPKTSRTAEQPRATLAPIEALFESrnveIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPE----- 526
Cdd:pfam03154  251 pmtqpppPSQVSPQPLPQPSLHGQMPPMPHS----LQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSqqrih 326

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  527 -PETRPSAQTTKAPRKTKKP----GHHRLRRPKTTRSPEVPKSKPALEPATVT---PEILVPKIVPKPPQKPKATRRPEV 598
Cdd:pfam03154  327 tPPSQSQLQSQQPPREQPLPpaplSMPHIKPPPTTPIPQLPNPQSHKHPPHLSgpsPFQMNSNLPPPPALKPLSSLSTHH 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  599 PqvkPAHEPVTFGSEAPALAIVTTTDIEPVITRTKASVTTLAPKPPRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEP 678
Cdd:pfam03154  407 P---PSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPT 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  679 PLASTTKKVRRPRPKPQTTPHPeVPHTilvPATSLEPFIITEAPgttlvPKLPQQPDYPHPKPkttRSPAASPTeLVPTP 758
Cdd:pfam03154  484 STSSAMPGIQPPSSASVSSSGP-VPAA---VSCPLPPVQIKEEA-----LDEAEEPESPPPPP---RSPSPEPT-VVNTP 550
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1360-1471 1.04e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.92  E-value: 1.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1360 PTEEATEGNATSPPqNPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEvISRENGSfSGKNKSIQITNQTFSTVENLKP 1439
Cdd:COG3401    220 PSNEVSVTTPTTPP-SAPTGLTATADT--PGSVTLSWDPVTESDATGYR-VYRSNSG-DGPFTKVATVTTTSYTDTGLTN 294

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1907118306 1440 DTSYEFQVKPKNPLG-EGPASNTVAFSTESADP 1471
Cdd:COG3401    295 GTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP 327
fn3 pfam00041
Fibronectin type III domain;
116-195 1.89e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.63  E-value: 1.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  116 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPSD-RFYTIRYREKDKEKKWIFQLCPATET--IVENLKPNTVYEF 192
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                   ...
gi 1907118306  193 GVK 195
Cdd:pfam00041   72 RVQ 74
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 114-195 2.62e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 2.62e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306   114 PRKPLQLVVGTLTPSSVFLSWgflinphhdwtLPSHCPSDRFYTIRYREKDKEKKWIFQLCPA----TETIVENLKPNTV 189
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSW-----------EPPPDDGITGYIVGYRVEYREEGSEWKEVNVtpssTSYTLTGLKPGTE 69


                    ....*.
gi 1907118306   190 YEFGVK 195
Cdd:smart00060   70 YEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 114-195 2.97e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.33  E-value: 2.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  114 PRKPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpsdrFYTIRYREKDKE--KKWIFQLCPATETIVENLKPNTVYE 191
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE 71


                   ....
gi 1907118306  192 FGVK 195
Cdd:cd00063     72 FRVR 75
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 491-703 6.48e-04

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 44.37  E-value: 6.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  491 PEVRPTTAAPQ---QTTSIPSTPKRQSTPKPPRVKPAPEPETrPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPA 567
Cdd:NF033839   286 EPGNKKPSAPKpgmQPSPQPEKKEVKPEPETPKPEVKPQLEK-PKPEVKPQPEKPKPEVKPQLETPKPEVKPQPEKPKPE 364

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  568 LEPATVTPEilvpKIVPKPPQKPKATRRPEVPQVKPAHEPvtfGSEAPalaivtTTDIEPVITRTKASVTTlAPKPPRPR 647
Cdd:NF033839   365 VKPQPEKPK----PEVKPQPETPKPEVKPQPEKPKPEVKP---QPEKP------KPEVKPQPEKPKPEVKP-QPEKPKPE 430

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907118306  648 THRQRTKYKTTQSPKIPHSKPAdlgpITSEPPLASTTKKVRRPRPKPQTTPHPEVP 703
Cdd:NF033839   431 VKPQPEKPKPEVKPQPEKPKPE----VKPQPETPKPEVKPQPEKPKPEVKPQPEKP 482
Not5 COG5665
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];
428-770 4.07e-03

CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];


Pssm-ID: 444384 [Multi-domain]  Cd Length: 874  Bit Score: 41.96  E-value: 4.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  428 ATYDVISSSTTSDETEIEIHTATR-------DPILDSVPPKTSRTAEQPRATLAPIEALFESRNVEIFTSPEVR------ 494
Cdd:COG5665    208 STPQAFNASATSGRSQHIVQAAKRvgvewwgDPSLLATPPATPATEEKSSQQPKSQPTSPSGGTTPPSTNQLTTsntpts 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  495 --------PTTAAPQQTTSIPSTPKRQSTPKPPRV--KPAPEPETRPSAQTTKAPRKTKKPGHhrlrRPKTTRSPEVPKS 564
Cdd:COG5665    288 takaqpqpPTKKQPAKEPPSDTASGNPSAPSVLINsdSPTSEDPATASVPTTEETTAFTTPSS----VPSTPAEKDTPAT 363

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  565 KPALEPATVTPEILV-PKIVPKPPQKPKATrrpevpqvkpAHEPVTFGSEAPalaivtttdiepvitrtkASVTTLAPKP 643
Cdd:COG5665    364 DLATPVSPTPPETSVdKKVSPDSATSSTKS----------EKEGGTASSPMP------------------PNIAIGAKDD 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  644 PRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEPPLAS--------TTKKVRRPRPKPQTTPHPEVPHTILVPATSLEP 715
Cdd:COG5665    416 VDATDPSQEAKEYTKNAPMTPEADSAPESSVRTEASPSAgsdlepenTTLRDPAPNAIPPPEDPSTIGRLSSGDKLANET 495

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  716 FIITEAPGTTLVPKLPQQ--PDYPHPKPKTT---RSPAASPTELVPTPVFEPVTPLKEDP 770
Cdd:COG5665    496 GPPVIRRDSTPSSTADQSivGVLAFGLDQRTqaeISVEAASRSNPLLNSQVKSFPLGKRS 555
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 507-889 3.82e-12

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 71.89  E-value: 3.82e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  507 PSTPKRQSTPKPPRVKPAPEPETRPS--AQTTKAPRKTKKPGHHRLRRPKTTR-SPEVPKSKPALEPATVTPEILVPKIV 583
Cdd:PHA03247  2553 PPLPPAAPPAAPDRSVPPPRPAPRPSepAVTSRARRPDAPPQSARPRAPVDDRgDPRGPAPPSPLPPDTHAPDPPPPSPS 2632

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  584 PKPPQ----KPKATRRPEVPQVKPAHEPVTFGSEAPALAIVTTTDIEPVITRTKA------SVTTLAPKPPRPRTHRQRT 653
Cdd:PHA03247  2633 PAANEpdphPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAarptvgSLTSLADPPPPPPTPEPAP 2712

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  654 KYKTTQSPKIP-------HSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPfIITEAPGTTL 726
Cdd:PHA03247  2713 HALVSATPLPPgpaaarqASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASL 2791

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  727 VPKLPQQPDYPHPKPKT--------TRSPAASPTELVPTPV-------------FEPVTPL-----------KEDPVTTI 774
Cdd:PHA03247  2792 SESRESLPSPWDPADPPaavlapaaALPPAASPAGPLPPPTsaqptapppppgpPPPSLPLggsvapggdvrRRPPSRSP 2871

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  775 ASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETKTVPAVVLEPVTLRPEVQVTTLAPQKTQKKHRPSPKPKPVPSPE 854
Cdd:PHA03247  2872 AAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG 2951

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 1907118306  855 VTESKPVLPRVREPVTLRTETWVT------------TKAPKTPKRTR 889
Cdd:PHA03247  2952 AGEPSGAVPQPWLGALVPGRVAVPrfrvpqpapsreAPASSTPPLTG 2998
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 509-778 7.41e-12

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 70.49  E-value: 7.41e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  509 TPKRQSTPKPPRV-----KPAPEPETRPSA--QTTKAPRKTKKPGHHRlrRPKTTRSPEVPKS--KPALEPATVTPEILV 579
Cdd:PTZ00449   542 EPKEGGKPGETKEgevgkKPGPAKEHKPSKipTLSKKPEFPKDPKHPK--DPEEPKKPKRPRSaqRPTRPKSPKLPELLD 619

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  580 PKIVPKPPQKPKATRRPevpqvkpahepvtfgseapalaivtttdiepvitrtkasvttlaPKPPRPRTHRQRTKYKTTQ 659
Cdd:PTZ00449   620 IPKSPKRPESPKSPKRP--------------------------------------------PPPQRPSSPERPEGPKIIK 655

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  660 SPKIPHSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPFIITEAPgTTLVPKLPQQPDYPHP 739
Cdd:PTZ00449   656 SPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTP-RPLPPKLPRDEEFPFE 734

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1907118306  740 KPKTTRSPAASPTELVPTPVfEPVTPLKEDPVTTIASKI 778
Cdd:PTZ00449   735 PIGDPDAEQPDDIEFFTPPE-EERTFFHETPADTPLPDI 772
PHA03247 PHA03247
large tegument protein UL36; Provisional
 448-779 5.63e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 5.63e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  448 TATRDPILDSVPPKTSRTAEQPRATLAPIEALFESRNVEIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEP 527
Cdd:PHA03247  2696 TSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP 2775

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  528 ETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKP-ALEPATVTPEILVPkivpkPPQKPKATRRPEVPQVKPAHE 606
Cdd:PHA03247  2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPaAALPPAASPAGPLP-----PPTSAQPTAPPPPPGPPPPSL 2850

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  607 PvTFGSEAPALAIVTTTDiepviTRTKASVTTLAPKPPRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKK 686
Cdd:PHA03247  2851 P-LGGSVAPGGDVRRRPP-----SRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP 2924

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  687 VR-RPRPKPQTTPHPEVPhtilvPATSLEPFIITEAPGTTLVPKLPQQPDYPHPKPKtTRSPAASPTELVPTPVFEPVTP 765
Cdd:PHA03247  2925 PPpQPQPPPPPPPRPQPP-----LAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPR-FRVPQPAPSREAPASSTPPLTG 2998

                          330
                   ....*....|....
gi 1907118306  766 LKEDPVTTIASKIS 779
Cdd:PHA03247  2999 HSLSRVSSWASSLA 3012
PHA03247 PHA03247
large tegument protein UL36; Provisional
 456-890 1.28e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.89  E-value: 1.28e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  456 DSVPPKTSRTAEQPRATLAPIEALFESRNveifTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPETRPSaqt 535
Cdd:PHA03247  2558 AAPPAAPDRSVPPPRPAPRPSEPAVTSRA----RRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPS--- 2630

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  536 tKAPRKTKKPGHHRLRRPKttrsPEVPKSKPAlePATVTPEILVPKIvPKPPQKPKATRRPEVPQVKPAHEPVTFGSEAP 615
Cdd:PHA03247  2631 -PSPAANEPDPHPPPTVPP----PERPRDDPA--PGRVSRPRRARRL-GRAAQASSPPQRPRRRAARPTVGSLTSLADPP 2702

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  616 AlaivtttdiepvitrtkasvttlAPKPPRPRTHRQRTKYKTTQSPKIPH--SKPADLGPITSEPPLASTTKKVRRPRPK 693
Cdd:PHA03247  2703 P-----------------------PPPTPEPAPHALVSATPLPPGPAAARqaSPALPAAPAPPAVPAGPATPGGPARPAR 2759

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  694 PQTTPHPEVPHTILVPATSLEPfIITEAPGTTLVPKLPQQPD----YPHPKPKTTRSPAASPTELVPTPVFEPVTPLKED 769
Cdd:PHA03247  2760 PPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASLSESRESLPSpwdpADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTA 2838

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  770 PVTT-------------IASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETKTVPAVVLEPVTLRPEVQVTTLAPQK 836
Cdd:PHA03247  2839 PPPPpgppppslplggsVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQ 2918

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907118306  837 TQKKHRPSPKPKPVPSPEVTESKPVLPR-----VREPVTLRTETWVTTKAPKTPKRTRR 890
Cdd:PHA03247  2919 PQPQPPPPPQPQPPPPPPPRPQPPLAPTtdpagAGEPSGAVPQPWLGALVPGRVAVPRF 2977
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1375-1466 3.02e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 3.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1375 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 1452
Cdd:cd00063      2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1907118306 1453 LGEGPASNTVAFST 1466
Cdd:cd00063     80 GGESPPSESVTVTT 93
PHA03247 PHA03247
large tegument protein UL36; Provisional
 545-1180 6.40e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.57  E-value: 6.40e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  545 PGHHRLRRPKTTRSPEVPKSKPalEPATVTPEilvPKIVPKPPQKPKATRRPEVPQVKPAHEPV-TFGSEAPALAIVTTT 623
Cdd:PHA03247  2475 PGAPVYRRPAEARFPFAAGAAP--DPGGGGPP---DPDAPPAPSRLAPAILPDEPVGEPVHPRMlTWIRGLEELASDDAG 2549

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  624 DIEPvitrtkasvtTLAPKPPRPRTHRQrtkykttqspkIPHSKPAdlgPITSEPplaSTTKKVRRPRPKPQttphpevP 703
Cdd:PHA03247  2550 DPPP----------PLPPAAPPAAPDRS-----------VPPPRPA---PRPSEP---AVTSRARRPDAPPQ-------S 2595

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  704 HTILVPATSLEPFIITEAPGTtlvpkLPQQPDYPHPKPKTTRSPAASPTELVPTPVFEPVTPlKEDPVTTIASKISQRTH 783
Cdd:PHA03247  2596 ARPRAPVDDRGDPRGPAPPSP-----LPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERP-RDDPAPGRVSRPRRARR 2669

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  784 RPRPRPRPRPRPRPRPKATLSPQAPETKTV--PAVVLEPVTLRPEVQVTTLAPQKTQKKHRPSPKPKPVPSPEVTESKPV 861
Cdd:PHA03247  2670 LGRAAQASSPPQRPRRRAARPTVGSLTSLAdpPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPA 2749

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  862 LPRVREPVTLRTetwvTTKAPKTPKRTRRPRPKPQTTPTPETPLTKPVAATDLEPSALSTEVPATVVLATALTPVTLR-- 939
Cdd:PHA03247  2750 TPGGPARPARPP----TTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASpa 2825

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  940 TKAPKTTTLAPNVQRTRRPHPRPKTTASTGVSE----SKSAPTelQSLVLKPVTS--PSLEIIQSQSVSDDLELVAFSTE 1013
Cdd:PHA03247  2826 GPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPS--RSPAAKPAAParPPVRRLARPAVSRSTESFALPPD 2903

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1014 SPQKtiaPRQTTSMPPKLKTPHSRMPAKEPVPKEPlhttskPKMPPSPEVADTTSVPKDERLSLKPDPEVTHSETVLPPV 1093
Cdd:PHA03247  2904 QPER---PPQPQAPPPPQPQPQPPPPPQPQPPPPP------PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAV 2974

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1094 T-FRVEPPKTTIAPLETRGIPLIPVISPRPSQEELQTAM-EETDQSTQELFTT-KIPRTTELAKTTQA----PHRLHTAP 1166
Cdd:PHA03247  2975 PrFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALhEETDPPPVSLKQTlWPPDDTEDSDADSLfdsdSERSDLEA 3054

                          650
                   ....*....|....
gi 1907118306 1167 VRPrIPGRPHGRPA 1180
Cdd:PHA03247  3055 LDP-LPPEPHDPFA 3067
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 511-928 3.15e-09

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 62.01  E-value: 3.15e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  511 KRQSTPKPPRVKPAPE--PETRPSAQTTKAPRK-TKKPGHHRlrRPKTTRSPEVPKsKPAlePATVTPEILVPKIVPKP- 586
Cdd:PTZ00449   506 KHDEPPEGPEASGLPPkaPGDKEGEEGEHEDSKeSDEPKEGG--KPGETKEGEVGK-KPG--PAKEHKPSKIPTLSKKPe 580

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  587 -PQKPKATRRPEVPQVKPAHEPVTFGSEAPALAIVTTTDIEPVITRTKASVTTLAPKPP-RPRTHRQRTKYKTTQSPKIP 664
Cdd:PTZ00449   581 fPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPqRPSSPERPEGPKIIKSPKPP 660

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  665 HSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPFIITEAPgTTLVPKLPQQPDYPHPKPKTT 744
Cdd:PTZ00449   661 KSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTP-RPLPPKLPRDEEFPFEPIGDP 739

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  745 RSPAASPTELVPTPVfEPVTPLKEDPVTTIASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETK---TVPAVV---- 817
Cdd:PTZ00449   740 DAEQPDDIEFFTPPE-EERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEAMKRPDSPSEHEDKppgDHPSLPkkrh 818

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  818 ----LEPVTLRPEVQVTTLAPQKTQKKHRPSPKPKPVPSPEVTESKPVLPRVREPVTLR-------TETWVTTKAPKTPK 886
Cdd:PTZ00449   819 rldgLALSTTDLESDAGRIAKDASGKIVKLKRSKSFDDLTTVEEAEEMGAEARKIVVDDdgteaddEDTHPPEEKHKSEV 898

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|..
gi 1907118306  887 RTRRPRPKPQTTPTPETPLTKPVAATDLEPSALSTEVPATVV 928
Cdd:PTZ00449   899 RRRRPPKKPSKPKKPSKPKKPKKPDSAFIPSIIAIFLVSLIV 940
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1376-1456 9.14e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 9.14e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  1376 PPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV-ISRENGSFSGKNKSIQITNQTFS-TVENLKPDTSYEFQVKPKNPL 1453
Cdd:smart00060    3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSyTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 1907118306  1454 GEG 1456
Cdd:smart00060   81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
1376-1459 1.21e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.79  E-value: 1.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1376 PPTNLTVVTVEgcPSFVILDWEKP--LNDTVTEYEVISRENGSFSGKNkSIQITNQTFS-TVENLKPDTSYEFQVKPKNP 1452
Cdd:pfam00041    2 APSNLTVTDVT--STSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWN-EITVPGTTTSvTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 1907118306 1453 LGEGPAS 1459
Cdd:pfam00041   79 GGEGPPS 85
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 494-817 5.15e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 51.61  E-value: 5.15e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  494 RPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEpetrpSAQTTKAPRKTKKPGhhRLRRPKTTRSPEVPKSKPALEPATV 573
Cdd:PTZ00449   560 KPGPAKEHKPSKIPTLSKKPEFPKDPKHPKDPE-----EPKKPKRPRSAQRPT--RPKSPKLPELLDIPKSPKRPESPKS 632

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  574 tpeilvPKiVPKPPQKPKATRRPEVPQV----KPAHEP-VTFG-----------SEAPALAIVTTTDIEPVITRTKASVT 637
Cdd:PTZ00449   633 ------PK-RPPPPQRPSSPERPEGPKIikspKPPKSPkPPFDpkfkekfyddyLDAAAKSKETKTTVVLDESFESILKE 705

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  638 TLAPKPPRPRTHRQRTKYKTTQSPKIPHSKPADlgpitsePPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPFI 717
Cdd:PTZ00449   706 TLPETPGTPFTTPRPLPPKLPRDEEFPFEPIGD-------PDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEFK 778

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  718 ITEAPGTTLVP----KLPQQPDYPHPKPKTT-----------------------------RSPAASPTELVPTPVFEPVT 764
Cdd:PTZ00449   779 EEDIHAETGEPdeamKRPDSPSEHEDKPPGDhpslpkkrhrldglalsttdlesdagriaKDASGKIVKLKRSKSFDDLT 858

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907118306  765 PLKEDPVT--------------------TIASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETKTVPAVV 817
Cdd:PTZ00449   859 TVEEAEEMgaearkivvdddgteaddedTHPPEEKHKSEVRRRRPPKKPSKPKKPSKPKKPKKPDSAFIPSII 931
PHA03377 PHA03377
EBNA-3C; Provisional
 517-703 5.93e-06

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 51.21  E-value: 5.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  517 KPPRVKPAPEPETRPSAQT---TKAPRKTKKPGHHRLRRPKTTRSPEVPkskpaLEPATVTPEILVPKIVPKPPQKPKAT 593
Cdd:PHA03377   414 RKPRTLPWPTPKTHPVKRTlvkTSGRSDEAEQAQSTPERPGPSDQPSVP-----VEPAHLTPVEHTTVILHQPPQSPPTV 488

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  594 rrpevpQVKPAHEPVTFGSEApalAIVTTTDIEPVITRTKASVTTLAPKPPRPRTHRQRTKYKTTQSPK---IPHSKPAD 670
Cdd:PHA03377   489 ------AIKPAPPPSRRRRGA---CVVYDDDIIEVIDVETTEEEESVTQPAKPHRKVQDGFQRSGRRQKratPPKVSPSD 559

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1907118306  671 LGPITSEPPLASTTKKVRRPRPKPQTTPHPEVP 703
Cdd:PHA03377   560 RGPPKASPPVMAPPSTGPRVMATPSTGPRDMAP 592
PHA03247 PHA03247
large tegument protein UL36; Provisional
 954-1397 7.22e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 7.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  954 RTRRPHPRPK-TTASTGVSESKSAPTELQSLVLKPVTSPSLEIIQSQSVSddlelvAFSTESPQKTIAPR----QTTSMP 1028
Cdd:PHA03247  2585 RARRPDAPPQsARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPA------ANEPDPHPPPTVPPperpRDDPAP 2658

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1029 PKLKTPH-SRMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSVPKDERLSLKPDPEVTHSETVLPPVTF--RVEPPKTTIA 1105
Cdd:PHA03247  2659 GRVSRPRrARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAaaRQASPALPAA 2738

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1106 PLeTRGIPLIPVI--SPRPSQEELQTAMEETDQSTQELFTTKIPRTTELAKTTQAPHRlhTAPVRPRIPGrPHGRPALNK 1183
Cdd:PHA03247  2739 PA-PPAVPAGPATpgGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESR--ESLPSPWDPA-DPPAAVLAP 2814

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1184 TTTRPDKTKPRGTSHKNGvgTGTKQAPKPPSPGRNASVDSHATRKPGSvSGTRRPPiphrhSSTRPVSPERRPLPPNNVT 1263
Cdd:PHA03247  2815 AAALPPAASPAGPLPPPT--SAQPTAPPPPPGPPPPSLPLGGSVAPGG-DVRRRPP-----SRSPAAKPAAPARPPVRRL 2886

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1264 GKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPTKETDPLGKPRFIGPHvryiP 1343
Cdd:PHA03247  2887 ARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQ----P 2962

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907118306 1344 KPENKPCSITDSVRRFPTEEATEGNATSPPQNPPTNLTVVTVEGCPSFVILDWE 1397
Cdd:PHA03247  2963 WLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEE 3016
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1158-1378 4.15e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 4.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1158 APHRLHTAPVRPRIPGRPHGRP---ALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPgrnASVDSHATRKPGSVSG 1234
Cdd:PHA03247  2556 PPAAPPAAPDRSVPPPRPAPRPsepAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSP---LPPDTHAPDPPPPSPS 2632

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1235 TRRPPIPHRHSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGT 1314
Cdd:PHA03247  2633 PAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAP 2712

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907118306 1315 TTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSITDSVRRFPTEEATEG-NATSPPQNPPT 1378
Cdd:PHA03247  2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGpPAPAPPAAPAA 2777
PHA03247 PHA03247
large tegument protein UL36; Provisional
 690-1322 4.95e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 4.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  690 PRPKPQTTPHPEVPHTILVPAtslePFIITEAPGTTLVPklPQQPDYPHPKPKTTRSPAASPTELVPtPVFEPVTPLKED 769
Cdd:PHA03247  2496 PDPGGGGPPDPDAPPAPSRLA----PAILPDEPVGEPVH--PRMLTWIRGLEELASDDAGDPPPPLP-PAAPPAAPDRSV 2568

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  770 PVTTIASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETKTVPAVVLEPVTLRPEVQVTTLAPQKTQKkhrPSPKPKP 849
Cdd:PHA03247  2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP---DPHPPPT 2645

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  850 VPSPEVTESKPVLPRVREPVTLR-----------TETWVTTKAPKT------------PKRTRRPRPKPQttptpetplt 906
Cdd:PHA03247  2646 VPPPERPRDDPAPGRVSRPRRARrlgraaqasspPQRPRRRAARPTvgsltsladpppPPPTPEPAPHAL---------- 2715

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  907 kpVAATDLEPSALStevpatvvlATALTPVTLRTKAPKTTTLAPNVQRTRRPHPRPKTTASTGVSESKSAP-TELQSLVL 985
Cdd:PHA03247  2716 --VSATPLPPGPAA---------ARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPaAGPPRRLT 2784

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  986 KPVTSPSLEIIQSQSVSDDLELVAFSTESPQKTIAPRQTTSMPpkLKTPHSRMPAKEPVPKEPLHTTSKP---------- 1055
Cdd:PHA03247  2785 RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP--LPPPTSAQPTAPPPPPGPPPPSLPLggsvapggdv 2862

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1056 -KMPPSPEVADTTSVPKDERLSLKPDPEVTHSETVLPPVTFRVEPPKTTIAPLEtrgiplipvisPRPSQEELQTAMEET 1134
Cdd:PHA03247  2863 rRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPP-----------PQPQPQPPPPPQPQP 2931

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1135 DQSTQELFTTKIPRTTELAKTTQAPHRLHTAPVRPRIPGRPhgrPALNKTTTRPDKTKPrgtshkngvgtgtkqAPKPPS 1214
Cdd:PHA03247  2932 PPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRV---AVPRFRVPQPAPSRE---------------APASST 2993

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1215 PGRNASVDSHATRKPGSVSgtrrppiPHRHSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSpplKATLHPIGTATA 1294
Cdd:PHA03247  2994 PPLTGHSLSRVSSWASSLA-------LHEETDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSD---LEALDPLPPEPH 3063

                          650       660
                   ....*....|....*....|....*...
gi 1907118306 1295 RPGAEQKEPTAPASEEEFGTTTDFSSSP 1322
Cdd:PHA03247  3064 DPFAHEPDPATPEAGARESPSSQFGPPP 3091
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 384-758 9.97e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.07  E-value: 9.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  384 PEFPEAKTAFPLEKPRGSWASSEEPWVVPGAKTSEDSRVVQPQTATYDVISSSTTSDETEIEIHTATRDPILDSV----- 458
Cdd:pfam03154  171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPhpplq 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  459 -------PPKTSRTAEQPRATLAPIEALFESrnveIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPE----- 526
Cdd:pfam03154  251 pmtqpppPSQVSPQPLPQPSLHGQMPPMPHS----LQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSqqrih 326

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  527 -PETRPSAQTTKAPRKTKKP----GHHRLRRPKTTRSPEVPKSKPALEPATVT---PEILVPKIVPKPPQKPKATRRPEV 598
Cdd:pfam03154  327 tPPSQSQLQSQQPPREQPLPpaplSMPHIKPPPTTPIPQLPNPQSHKHPPHLSgpsPFQMNSNLPPPPALKPLSSLSTHH 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  599 PqvkPAHEPVTFGSEAPALAIVTTTDIEPVITRTKASVTTLAPKPPRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEP 678
Cdd:pfam03154  407 P---PSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPT 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  679 PLASTTKKVRRPRPKPQTTPHPeVPHTilvPATSLEPFIITEAPgttlvPKLPQQPDYPHPKPkttRSPAASPTeLVPTP 758
Cdd:pfam03154  484 STSSAMPGIQPPSSASVSSSGP-VPAA---VSCPLPPVQIKEEA-----LDEAEEPESPPPPP---RSPSPEPT-VVNTP 550
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1360-1471 1.04e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.92  E-value: 1.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1360 PTEEATEGNATSPPqNPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEvISRENGSfSGKNKSIQITNQTFSTVENLKP 1439
Cdd:COG3401    220 PSNEVSVTTPTTPP-SAPTGLTATADT--PGSVTLSWDPVTESDATGYR-VYRSNSG-DGPFTKVATVTTTSYTDTGLTN 294

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1907118306 1440 DTSYEFQVKPKNPLG-EGPASNTVAFSTESADP 1471
Cdd:COG3401    295 GTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP 327
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1360-1514 1.36e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.53  E-value: 1.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1360 PTEEATEGNATSPPQnPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV--ISRENGSFSGKNKSIqitNQTFSTVENL 1437
Cdd:COG3401    314 PSNVVSVTTDLTPPA-APSGLTATAVG--SSSITLSWTASSDADVTGYNVyrSTSGGGTYTKIAETV---TTTSYTDTGL 387

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907118306 1438 KPDTSYEFQVKPKNPLG-EGPASNTVAFSTESADPRVSEPISAGRDAIWTERPFNSDSYSECKGKQYVKRTWYKKFVG 1514
Cdd:COG3401    388 TPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTG 465
fn3 pfam00041
Fibronectin type III domain;
116-195 1.89e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.63  E-value: 1.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  116 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPSD-RFYTIRYREKDKEKKWIFQLCPATET--IVENLKPNTVYEF 192
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                   ...
gi 1907118306  193 GVK 195
Cdd:pfam00041   72 RVQ 74
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 553-777 2.50e-04

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 45.69  E-value: 2.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  553 PKTTRSPEVPKSKPalePATVTPEILVPKIVPKPPQKPKATRRPEVP-----QVKPAHEPVTFGSEAPALAIVTTTDIEP 627
Cdd:PLN03209   330 PKESDAADGPKPVP---TKPVTPEAPSPPIEEEPPQPKAVVPRPLSPytayeDLKPPTSPIPTPPSSSPASSKSVDAVAK 406

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  628 VITRTKASVTTLAPKPPRPRTHRQRTKyktTQSPKIPHSKPADLGPITSepplasttkkvrrPRPKPQTTPHPEVPHTIL 707
Cdd:PLN03209   407 PAEPDVVPSPGSASNVPEVEPAQVEAK---KTRPLSPYARYEDLKPPTS-------------PSPTAPTGVSPSVSSTSS 470

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907118306  708 VPATSLEP----FIITEAPGTTLVPKLPQQPDYPHPKPKTTRSPAASPTELVPTPVFEPVTPLKEDPVTTIASK 777
Cdd:PLN03209   471 VPAVPDTApataATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALADE 544
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 114-195 2.62e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 2.62e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306   114 PRKPLQLVVGTLTPSSVFLSWgflinphhdwtLPSHCPSDRFYTIRYREKDKEKKWIFQLCPA----TETIVENLKPNTV 189
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSW-----------EPPPDDGITGYIVGYRVEYREEGSEWKEVNVtpssTSYTLTGLKPGTE 69


                    ....*.
gi 1907118306   190 YEFGVK 195
Cdd:smart00060   70 YEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 114-195 2.97e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.33  E-value: 2.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  114 PRKPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpsdrFYTIRYREKDKE--KKWIFQLCPATETIVENLKPNTVYE 191
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE 71


                   ....
gi 1907118306  192 FGVK 195
Cdd:cd00063     72 FRVR 75
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 515-626 5.12e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 44.80  E-value: 5.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  515 TPKPPRVKPAPEPETRPSAQTTKAPRKTKKPGHHRLRRPKttrsPEVPKSKPalePATVTPEILVPKIVPKPPQKPKATR 594
Cdd:PRK14950   361 VPVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPK----EPVRETAT---PPPVPPRPVAPPVPHTPESAPKLTR 433

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1907118306  595 RPEVPQVKPAHEPVTFGSEAPALAIVTTTDIE 626
Cdd:PRK14950   434 AAIPVDEKPKYTPPAPPKEEEKALIADGDVLE 465
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 491-703 6.48e-04

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 44.37  E-value: 6.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  491 PEVRPTTAAPQ---QTTSIPSTPKRQSTPKPPRVKPAPEPETrPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPA 567
Cdd:NF033839   286 EPGNKKPSAPKpgmQPSPQPEKKEVKPEPETPKPEVKPQLEK-PKPEVKPQPEKPKPEVKPQLETPKPEVKPQPEKPKPE 364

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  568 LEPATVTPEilvpKIVPKPPQKPKATRRPEVPQVKPAHEPvtfGSEAPalaivtTTDIEPVITRTKASVTTlAPKPPRPR 647
Cdd:NF033839   365 VKPQPEKPK----PEVKPQPETPKPEVKPQPEKPKPEVKP---QPEKP------KPEVKPQPEKPKPEVKP-QPEKPKPE 430

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907118306  648 THRQRTKYKTTQSPKIPHSKPAdlgpITSEPPLASTTKKVRRPRPKPQTTPHPEVP 703
Cdd:NF033839   431 VKPQPEKPKPEVKPQPEKPKPE----VKPQPETPKPEVKPQPEKPKPEVKPQPEKP 482
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
458-771 1.49e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.30  E-value: 1.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  458 VPPKTSRTAEQPRATLAP---IEALFESRNVEIFTSPEVRPTTAAPQQTTsIPSTPKRQSTPKP-------PRVKPAPEP 527
Cdd:PRK07003   372 VPARVAGAVPAPGARAAAavgASAVPAVTAVTGAAGAALAPKAAAAAAAT-RAEAPPAAPAPPAtadrgddAADGDAPVP 450

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  528 ---ETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPALEPATVTPEILVPKIVPKPPQ--------KPKATRRP 596
Cdd:PRK07003   451 akaNARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAaasredapAAAAPPAP 530

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  597 EVPQVKPA--HEPVTFGSEAPALAIVTTTDIEPVITRTK--------ASVTTLAPKPPRPRTHRQrtkyktTQSPKIPHS 666
Cdd:PRK07003   531 EARPPTPAaaAPAARAGGAAAALDVLRNAGMRVSSDRGAraaaaakpAAAPAAAPKPAAPRVAVQ------VPTPRARAA 604

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  667 KPADLGPITSEPPLASTTkkvRRPRPkpqttPHPEVPHTILVPATSLEPFIiteAPGTTLVPKLPQQPDYPHPKPKTTRS 746
Cdd:PRK07003   605 TGDAPPNGAARAEQAAES---RGAPP-----PWEDIPPDDYVPLSADEGFG---GPDDGFVPVFDSGPDDVRVAPKPADA 673

                          330       340
                   ....*....|....*....|....*
gi 1907118306  747 PAAsPTELVPTPvfePVTPLkeDPV 771
Cdd:PRK07003   674 PAP-PVDTRPLP---PAIPL--DAI 692
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 420-747 1.54e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.54  E-value: 1.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  420 SRVVQPQTATYDVI---------SSSTTSDETEIEIHTATRDPILDSVPPKTSRTA-EQPRATLAPIEALFESRNVeIFT 489
Cdd:PRK10263   297 NRATQPEYDEYDPLlngapitepVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPpAQPTVAWQPVPGPQTGEPV-IAP 375

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  490 SPEVRPTTAAPQQTTSIPSTPKRQSTP--KPPRVKPAPEPETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPA 567
Cdd:PRK10263   376 APEGYPQQSQYAQPAVQYNEPLQQPVQpqQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQST 455

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  568 LEP-ATVTPEILVPKIVPKPP---------QKPKATRRPEVPQVKPAHEPVTFGSEapalaivtttdIEPVITRTKASVT 637
Cdd:PRK10263   456 FAPqSTYQTEQTYQQPAAQEPlyqqpqpveQQPVVEPEPVVEETKPARPPLYYFEE-----------VEEKRAREREQLA 524

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  638 TLAPKPPRPrthrqrTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKKVRrprpkpQTTPHPEVPHTILVPATSLepfi 717
Cdd:PRK10263   525 AWYQPIPEP------VKEPEPIKSSLKAPSVAAVPPVEAAAAVSPLASGVK------KATLATGAAATVAAPVFSL---- 588

                          330       340       350
                   ....*....|....*....|....*....|
gi 1907118306  718 iteAPGTTLVPKLPQQPDYPHPKPKTTRSP 747
Cdd:PRK10263   589 ---ANSGGPRPQVKEGIGPQLPRPKRIRVP 615
PHA03369 PHA03369
capsid maturational protease; Provisional
 491-779 1.76e-03

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 43.06  E-value: 1.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  491 PEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPALEP 570
Cdd:PHA03369   362 AAAKVAVIAAPQTHTGPADRQRPQRPDGIPYSVPARSPMTAYPPVPQFCGDPGLVSPYNPQSPGTSYGPEPVGPVPPQPT 441

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  571 ATVTPEILVPKIVPKPPQKPKATRRPEVPQVKPAHEPVTFGSEAPalaivtTTDIEPVITRTKASVTTLAPKPPRPRTHR 650
Cdd:PHA03369   442 NPYVMPISMANMVYPGHPQEHGHERKRKRGGELKEELIETLKLVK------KLKEEQESLAKELEATAHKSEIKKIAESE 515

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  651 QRTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPFIITEAPGT------ 724
Cdd:PHA03369   516 FKNAGAKTAAANIEPNCSADAAAPATKRARPETKTELEAVVRFPYQIRNMESPAFVHSFTSTTLAAAAGQGSDTaealag 595

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907118306  725 ---TLVPKLPQQPDYPHpkpktTRSPAASPTELVPTPVFEPVTPLKEDPVTTIASKIS 779
Cdd:PHA03369   596 aieTLLTQASAQPAGLS-----LPAPAVPVNASTPASTPPPLAPQEPPQPGTSAPSLE 648
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 490-618 1.84e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 42.93  E-value: 1.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  490 SPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEV-PKSKPAL 568
Cdd:PRK07994   370 VPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKSePAAASRA 449

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907118306  569 EPATVTPEIL-----VPKIVPKPPQKPKATR-RPEVPQVKPAHEPVTFGSEAPALA 618
Cdd:PRK07994   450 RPVNSALERLasvrpAPSALEKAPAKKEAYRwKATNPVEVKKEPVATPKALKKALE 505
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1015-1266 1.93e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.14  E-value: 1.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1015 PQKTIAPRQTTSMPPKLKTPhsRMPAKEPVPKEPLhTTSKPKMPPSPEVADTTSVPKDERLSLKPDPEVTHSETVLPPVT 1094
Cdd:PTZ00449   569 PSKIPTLSKKPEFPKDPKHP--KDPEEPKKPKRPR-SAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSP 645

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1095 FRVEPPKT--TIAPLETRGIPLIPVISPRPSQEELQTAMEETDQST----QELFTTKIPRTTELAKTTQAPHRLHTAPVR 1168
Cdd:PTZ00449   646 ERPEGPKIikSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTtvvlDESFESILKETLPETPGTPFTTPRPLPPKL 725

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1169 PRIPGRPHGRPAlnktttRPDKTKPRGTSHKNGVGTGTKQAPKPPSPGRNASVDSHATRKPGSVSGTRRPPIPHRhsstR 1248
Cdd:PTZ00449   726 PRDEEFPFEPIG------DPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEAMK----R 795

                          250
                   ....*....|....*....
gi 1907118306 1249 PVSP-ERRPLPPNNVTGKP 1266
Cdd:PTZ00449   796 PDSPsEHEDKPPGDHPSLP 814
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 480-628 2.18e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.49  E-value: 2.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  480 FESRNVEIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPETRPSAQTTKAPRKTKKPghhrLRRPKTTRSP 559
Cdd:PRK14950   351 LELAVIEALLVPVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRP----VAPPVPHTPE 426

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907118306  560 EVPKSKPALEPATVTPEILVPkivPKPPQKPKATRRPEV--PQVKPAHEPVT--FGSEAPALAIVTTTDIEPV 628
Cdd:PRK14950   427 SAPKLTRAAIPVDEKPKYTPP---APPKEEEKALIADGDvlEQLEAIWKQILrdVPPRSPAVQALLSSGVRPV 496
dnaA PRK14086
chromosomal replication initiator protein DnaA;
515-718 2.54e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 42.51  E-value: 2.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  515 TPKPPRVKPAPEPETRPSAQTTKAPRKTKKP----GHHRL--RRPKTTRSPEVPKSKPALEPATVTPE--ILVPKIVPKP 586
Cdd:PRK14086    87 TVDPSAGEPAPPPPHARRTSEPELPRPGRRPyegyGGPRAddRPPGLPRQDQLPTARPAYPAYQQRPEpgAWPRAADDYG 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  587 PQKPKATRRPEVPQVKPAHEPVTFGSEAPALAivtttDIEPVITRTKASVTTLAPKPPRPRTHRQRTKYKTTQSPKIPHS 666
Cdd:PRK14086   167 WQQQRLGFPPRAPYASPASYAPEQERDREPYD-----AGRPEYDQRRRDYDHPRPDWDRPRRDRTDRPEPPPGAGHVHRG 241

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907118306  667 KPADLGPItSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPFII 718
Cdd:PRK14086   242 GPGPPERD-DAPVVPIRPSAPGPLAAQPAPAPGPGEPTARLNPKYTFDTFVI 292
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 491-766 2.94e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 2.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  491 PEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPALEP 570
Cdd:pfam03154  172 PVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQP 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  571 ATVT--PEILVPKIVPKPPQKPKATRRPEVPQVKPAHEPvtfgseapalaivtttdiepvitrtkasvttlAPKPPRPRT 648
Cdd:pfam03154  252 MTQPppPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQ--------------------------------HPVPPQPFP 299

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  649 hrqrTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKKVRRPRPkPQTTPHPEVPhtilVPATSLEPfiiteaPGTTLVP 728
Cdd:pfam03154  300 ----LTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQP-PREQPLPPAP----LSMPHIKP------PPTTPIP 364

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1907118306  729 KLPQQPDYPHPKPKTTRSPAASPTELVPTPVFEPVTPL 766
Cdd:pfam03154  365 QLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSL 402
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 469-600 3.46e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 3.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  469 PRATLAPIEALfESRNVEIFTSPEVRPT----TAAPQQTTSIPSTPKRQSTPKPPRVkPAPEPETRPSAQTTKAPRKTKK 544
Cdd:PRK07764   371 ERGLLARLERL-ERRLGVAGGAGAPAAAapsaAAAAPAAAPAPAAAAPAAAAAPAPA-AAPQPAPAPAPAPAPPSPAGNA 448

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907118306  545 PGHHRLRRPKTTRSPEVPKSKPALEPATVTPEILVPKIVPKPPQKPKATRRPEVPQ 600
Cdd:PRK07764   449 PAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPA 504
Not5 COG5665
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];
428-770 4.07e-03

CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];


Pssm-ID: 444384 [Multi-domain]  Cd Length: 874  Bit Score: 41.96  E-value: 4.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  428 ATYDVISSSTTSDETEIEIHTATR-------DPILDSVPPKTSRTAEQPRATLAPIEALFESRNVEIFTSPEVR------ 494
Cdd:COG5665    208 STPQAFNASATSGRSQHIVQAAKRvgvewwgDPSLLATPPATPATEEKSSQQPKSQPTSPSGGTTPPSTNQLTTsntpts 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  495 --------PTTAAPQQTTSIPSTPKRQSTPKPPRV--KPAPEPETRPSAQTTKAPRKTKKPGHhrlrRPKTTRSPEVPKS 564
Cdd:COG5665    288 takaqpqpPTKKQPAKEPPSDTASGNPSAPSVLINsdSPTSEDPATASVPTTEETTAFTTPSS----VPSTPAEKDTPAT 363

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  565 KPALEPATVTPEILV-PKIVPKPPQKPKATrrpevpqvkpAHEPVTFGSEAPalaivtttdiepvitrtkASVTTLAPKP 643
Cdd:COG5665    364 DLATPVSPTPPETSVdKKVSPDSATSSTKS----------EKEGGTASSPMP------------------PNIAIGAKDD 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  644 PRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEPPLAS--------TTKKVRRPRPKPQTTPHPEVPHTILVPATSLEP 715
Cdd:COG5665    416 VDATDPSQEAKEYTKNAPMTPEADSAPESSVRTEASPSAgsdlepenTTLRDPAPNAIPPPEDPSTIGRLSSGDKLANET 495

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  716 FIITEAPGTTLVPKLPQQ--PDYPHPKPKTT---RSPAASPTELVPTPVFEPVTPLKEDP 770
Cdd:COG5665    496 GPPVIRRDSTPSSTADQSivGVLAFGLDQRTqaeISVEAASRSNPLLNSQVKSFPLGKRS 555
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 515-612 4.37e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 41.85  E-value: 4.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  515 TPKPPRVKPAPEPETrPSAQTTKAPRKTKKPGhhrlRRPKTTRSPEvpkSKPAlePATVTPeilVPKIVPKPPqKPKATR 594
Cdd:PRK14954   385 AGSPDVKKKAPEPDL-PQPDRHPGPAKPEAPG----ARPAELPSPA---SAPT--PEQQPP---VARSAPLPP-SPQASA 450

                           90
                   ....*....|....*...
gi 1907118306  595 RPEVPQVKPAhepVTFGS 612
Cdd:PRK14954   451 PRNVASGKPG---VDLGS 465
PHA03247 PHA03247
large tegument protein UL36; Provisional
 531-781 4.63e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 4.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  531 PSAQTTKAPRKTKKPGHHRlrrpKTTRSPEVPKSKPALEPATVTPEILVPKIVPKPPQKPKATRRPEVPqvkPAHEPVTF 610
Cdd:PHA03247   255 PAPPPVVGEGADRAPETAR----GATGPPPPPEAAAPNGAAAPPDGVWGAALAGAPLALPAPPDPPPPA---PAGDAEEE 327

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  611 GSEAPALAIVTttdiePVitrtkasvttlapkpPRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKKVRRp 690
Cdd:PHA03247   328 DDEDGAMEVVS-----PL---------------PRPRQHYPLGFPKRRRPTWTPPSSLEDLSAGRHHPKRASLPTRKRR- 386

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  691 rpkpqTTPHPEVPHTiLVPATSLEPFIITEAPGTTLVPKLPQQPDYPHPKPKTTRSPAASPTELVPTPVFEPVTPLKEDP 770
Cdd:PHA03247   387 -----SARHAATPFA-RGPGGDDQTRPAAPVPASVPTPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPERQPPAPATE 460

                          250
                   ....*....|.
gi 1907118306  771 VTTIASKISQR 781
Cdd:PHA03247   461 PAPDDPDDATR 471
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 669-836 4.69e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.99  E-value: 4.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  669 ADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPFIITEAPGTTLVPKLPQQPDYPHPKPKTTRSPA 748
Cdd:PRK10263   335 APVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQ 414

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  749 ASPTELVPTPVFEPVTPLKEDPVTTIASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETKTV-PAVVLEPVTLRPEV 827
Cdd:PRK10263   415 PAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQqPQPVEQQPVVEPEP 494


                   ....*....
gi 1907118306  828 QVTTLAPQK 836
Cdd:PRK10263   495 VVEETKPAR 503
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
1372-1471 5.10e-03

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 41.30  E-value: 5.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306 1372 PPQNPpTNLTVVTVEgcPSFVILDWEK-PLNDTVTEYEVisrengsFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPK 1450
Cdd:COG3979      2 APTAP-TGLTASNVT--SSSVSLSWDAsTDNVGVTGYDV-------YRGGDQVATVTGLTAWTVTGLTPGTEYTFTVGAC 71

                           90       100
                   ....*....|....*....|.
gi 1907118306 1451 nplgeGPASNTVAFSTESADP 1471
Cdd:COG3979     72 -----DAAGNVSAASGTSTAM 87
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
491-673 5.22e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 5.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  491 PEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPALEP 570
Cdd:PRK12323   383 AQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAA 462

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118306  571 ATVTPEIL---VPKIVPKPPQKPKATRRPEVPQVKPAHE-PVTFGSEAPA------LAIVTTTDIEPVITRTKASVTTLA 640
Cdd:PRK12323   463 RPAAAGPRpvaAAAAAAPARAAPAAAPAPADDDPPPWEElPPEFASPAPAqpdaapAGWVAESIPDPATADPDDAFETLA 542

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1907118306  641 PKPPRPRTHRQRTKYKTTQSPKIPHSKPADLGP 673
Cdd:PRK12323   543 PAPAAAPAPRAAAATEPVVAPRPPRASASGLPD 575
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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