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Conserved domains on  [gi|1907116832|ref|XP_036015698|]
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ubinuclein-1 isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UBN_AB super family cl16591
Ubinuclein conserved middle domain; Ubinuclein 1 and 2 (UBN1, UBN2) are members of a histone ...
 1-118 4.86e-43

Ubinuclein conserved middle domain; Ubinuclein 1 and 2 (UBN1, UBN2) are members of a histone chaperone complex involved in the formation of a certain type of facultative heterochromatin, called senescence-associated heterochromatin foci (SAHF). The domain described here is conserved in many eukaryotes such as human, rat, drosophila, and zebra-fish and has been targeted for protein structure determination by the Joint Center for Structural Genomics.


The actual alignment was detected with superfamily member pfam14075:

Pssm-ID: 464081  Cd Length: 212  Bit Score: 154.38  E-value: 4.86e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116832   1 MPEQVAKYQDECQAHTQAKVAKMLEEEKDKEQREricsdeeeDEEKGGRRIMGPRKKFQWNDEIRELLCQVVKIKLESRD 80
Cdd:pfam14075 104 MPEQIAKYELECQAWAEAKAAKKAEDGPDTDEDD--------DDEKKEKRPKGPRKKFQWNEELRTLLWDIVQLRNESYE 175

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1907116832  81 LERNSKaQAWEDCVKAFLDAEVKPLWPKGWMQARTLFK 118
Cdd:pfam14075 176 LENNRK-QSAEEFLKKFLYKEVKPLWPKGWMQSRELQK 212
 
Name Accession Description Interval E-value
UBN_AB pfam14075
Ubinuclein conserved middle domain; Ubinuclein 1 and 2 (UBN1, UBN2) are members of a histone ...
 1-118 4.86e-43

Ubinuclein conserved middle domain; Ubinuclein 1 and 2 (UBN1, UBN2) are members of a histone chaperone complex involved in the formation of a certain type of facultative heterochromatin, called senescence-associated heterochromatin foci (SAHF). The domain described here is conserved in many eukaryotes such as human, rat, drosophila, and zebra-fish and has been targeted for protein structure determination by the Joint Center for Structural Genomics.


Pssm-ID: 464081  Cd Length: 212  Bit Score: 154.38  E-value: 4.86e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116832   1 MPEQVAKYQDECQAHTQAKVAKMLEEEKDKEQREricsdeeeDEEKGGRRIMGPRKKFQWNDEIRELLCQVVKIKLESRD 80
Cdd:pfam14075 104 MPEQIAKYELECQAWAEAKAAKKAEDGPDTDEDD--------DDEKKEKRPKGPRKKFQWNEELRTLLWDIVQLRNESYE 175

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1907116832  81 LERNSKaQAWEDCVKAFLDAEVKPLWPKGWMQARTLFK 118
Cdd:pfam14075 176 LENNRK-QSAEEFLKKFLYKEVKPLWPKGWMQSRELQK 212
 
Name Accession Description Interval E-value
UBN_AB pfam14075
Ubinuclein conserved middle domain; Ubinuclein 1 and 2 (UBN1, UBN2) are members of a histone ...
 1-118 4.86e-43

Ubinuclein conserved middle domain; Ubinuclein 1 and 2 (UBN1, UBN2) are members of a histone chaperone complex involved in the formation of a certain type of facultative heterochromatin, called senescence-associated heterochromatin foci (SAHF). The domain described here is conserved in many eukaryotes such as human, rat, drosophila, and zebra-fish and has been targeted for protein structure determination by the Joint Center for Structural Genomics.


Pssm-ID: 464081  Cd Length: 212  Bit Score: 154.38  E-value: 4.86e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116832   1 MPEQVAKYQDECQAHTQAKVAKMLEEEKDKEQREricsdeeeDEEKGGRRIMGPRKKFQWNDEIRELLCQVVKIKLESRD 80
Cdd:pfam14075 104 MPEQIAKYELECQAWAEAKAAKKAEDGPDTDEDD--------DDEKKEKRPKGPRKKFQWNEELRTLLWDIVQLRNESYE 175

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1907116832  81 LERNSKaQAWEDCVKAFLDAEVKPLWPKGWMQARTLFK 118
Cdd:pfam14075 176 LENNRK-QSAEEFLKKFLYKEVKPLWPKGWMQSRELQK 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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