NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907114391|ref|XP_036015517|]
View 

coiled-coil domain-containing protein 134 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ERK-JNK_inhib super family cl20880
ERK and JNK pathways, inhibitor; This coiled-coiled domain, CCDC134, is a secretory protein ...
 27-151 2.23e-53

ERK and JNK pathways, inhibitor; This coiled-coiled domain, CCDC134, is a secretory protein that inhibits Mitogen activated protein kinase (MAPK) pathways such as Raf-1/MEK/ERK and JNK/SAPK but not p38. CCDC134 is widely expressed in normal adult tissues, tumour tissues and cell lines, which shows its importance in cell signal transduction pathways, transcription regulation and therefore cell survival. Additionally, CCDC134 is known to bind to a transcription adaptor, hADA2a, which forms part of the general control nonderepressible 5 (GCN5) histone acetyltransferase complex. Acetylation usually 'switches genes on' for transcription. Moreover, knocking out CCDC134 suppressed hADA2a-induced cell apoptosis activity and G1/S cell cycle arrest suggesting its importance in cell survival. This family of proteins is found in eukaryotes. Proteins in this family are typically between 188 and 257 amino acids in length. This family is a coiled-coil domain containing protein 134 (CCDC134) whereby the coiled-coiled domain is a ubiquitous motif involved in oligomerization.


The actual alignment was detected with superfamily member pfam15002:

Pssm-ID: 464435  Cd Length: 197  Bit Score: 168.28  E-value: 2.23e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114391  27 LQVLEDSRTVLIAADVLPDGPVPQDEKLKDAFSHVVENTAFFGDVVLRFPKIVHHYFDHNSNWNLLIRWGISFCNQTGVF 106
Cdd:pfam15002  55 FKVLRESRIKLEKAGITPESPFPKDEELKDALSKVLENTAFFGDLVLHFPDIVHTILKKDRDWKTLVRWALNFTNQSRHF 134

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1907114391 107 DQGPHSPILSLMAQELGITEKDSDFRNPFKTDQTEFIPSTDPFQK 151
Cdd:pfam15002 135 LDDKTEKLLGLMAQELEIIERDPNYVNPYRREEAQKILEAEPKKR 179
 
Name Accession Description Interval E-value
ERK-JNK_inhib pfam15002
ERK and JNK pathways, inhibitor; This coiled-coiled domain, CCDC134, is a secretory protein ...
 27-151 2.23e-53

ERK and JNK pathways, inhibitor; This coiled-coiled domain, CCDC134, is a secretory protein that inhibits Mitogen activated protein kinase (MAPK) pathways such as Raf-1/MEK/ERK and JNK/SAPK but not p38. CCDC134 is widely expressed in normal adult tissues, tumour tissues and cell lines, which shows its importance in cell signal transduction pathways, transcription regulation and therefore cell survival. Additionally, CCDC134 is known to bind to a transcription adaptor, hADA2a, which forms part of the general control nonderepressible 5 (GCN5) histone acetyltransferase complex. Acetylation usually 'switches genes on' for transcription. Moreover, knocking out CCDC134 suppressed hADA2a-induced cell apoptosis activity and G1/S cell cycle arrest suggesting its importance in cell survival. This family of proteins is found in eukaryotes. Proteins in this family are typically between 188 and 257 amino acids in length. This family is a coiled-coil domain containing protein 134 (CCDC134) whereby the coiled-coiled domain is a ubiquitous motif involved in oligomerization.


Pssm-ID: 464435  Cd Length: 197  Bit Score: 168.28  E-value: 2.23e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114391  27 LQVLEDSRTVLIAADVLPDGPVPQDEKLKDAFSHVVENTAFFGDVVLRFPKIVHHYFDHNSNWNLLIRWGISFCNQTGVF 106
Cdd:pfam15002  55 FKVLRESRIKLEKAGITPESPFPKDEELKDALSKVLENTAFFGDLVLHFPDIVHTILKKDRDWKTLVRWALNFTNQSRHF 134

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1907114391 107 DQGPHSPILSLMAQELGITEKDSDFRNPFKTDQTEFIPSTDPFQK 151
Cdd:pfam15002 135 LDDKTEKLLGLMAQELEIIERDPNYVNPYRREEAQKILEAEPKKR 179
 
Name Accession Description Interval E-value
ERK-JNK_inhib pfam15002
ERK and JNK pathways, inhibitor; This coiled-coiled domain, CCDC134, is a secretory protein ...
 27-151 2.23e-53

ERK and JNK pathways, inhibitor; This coiled-coiled domain, CCDC134, is a secretory protein that inhibits Mitogen activated protein kinase (MAPK) pathways such as Raf-1/MEK/ERK and JNK/SAPK but not p38. CCDC134 is widely expressed in normal adult tissues, tumour tissues and cell lines, which shows its importance in cell signal transduction pathways, transcription regulation and therefore cell survival. Additionally, CCDC134 is known to bind to a transcription adaptor, hADA2a, which forms part of the general control nonderepressible 5 (GCN5) histone acetyltransferase complex. Acetylation usually 'switches genes on' for transcription. Moreover, knocking out CCDC134 suppressed hADA2a-induced cell apoptosis activity and G1/S cell cycle arrest suggesting its importance in cell survival. This family of proteins is found in eukaryotes. Proteins in this family are typically between 188 and 257 amino acids in length. This family is a coiled-coil domain containing protein 134 (CCDC134) whereby the coiled-coiled domain is a ubiquitous motif involved in oligomerization.


Pssm-ID: 464435  Cd Length: 197  Bit Score: 168.28  E-value: 2.23e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114391  27 LQVLEDSRTVLIAADVLPDGPVPQDEKLKDAFSHVVENTAFFGDVVLRFPKIVHHYFDHNSNWNLLIRWGISFCNQTGVF 106
Cdd:pfam15002  55 FKVLRESRIKLEKAGITPESPFPKDEELKDALSKVLENTAFFGDLVLHFPDIVHTILKKDRDWKTLVRWALNFTNQSRHF 134

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1907114391 107 DQGPHSPILSLMAQELGITEKDSDFRNPFKTDQTEFIPSTDPFQK 151
Cdd:pfam15002 135 LDDKTEKLLGLMAQELEIIERDPNYVNPYRREEAQKILEAEPKKR 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH