|
Name |
Accession |
Description |
Interval |
E-value |
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1079-1483 |
1.64e-15 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 83.83 E-value: 1.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1079 QALGITPTPQPITLTPEQAQALGITPTPQPTTLTPEQTQALGITPTPQPITLTPEQAQALGIT-PTPQPITLTPEQTQAL 1157
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAdPPPPPPTPEPAPHALV 2716
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1158 GITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPqPITLTPEQAQALGITPTPQPITLTPEQAQALGITP 1237
Cdd:PHA03247 2717 SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP-PTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESR 2795
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1238 TPQPITLTPEQAQALGITPTPqpiTLTPEQTQALGITPTPQPITLTPEQaqalgiTPTPQPITLTPEQVQALGITPTPQP 1317
Cdd:PHA03247 2796 ESLPSPWDPADPPAAVLAPAA---ALPPAASPAGPLPPPTSAQPTAPPP------PPGPPPPSLPLGGSVAPGGDVRRRP 2866
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1318 itlTPEQAQALGITPTPQPITLTPEQAqalgITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLT 1397
Cdd:PHA03247 2867 ---PSRSPAAKPAAPARPPVRRLARPA----VSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRP 2939
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1398 PelvqalgitPTPQPITLTPEQAQALGITPTPQPTTLSPEQaqalgitpTPQPITLTPEQAQALgitPTPQPTTLSPEQA 1477
Cdd:PHA03247 2940 Q---------PPLAPTTDPAGAGEPSGAVPQPWLGALVPGR--------VAVPRFRVPQPAPSR---EAPASSTPPLTGH 2999
|
....*.
gi 1907114282 1478 QALGIS 1483
Cdd:PHA03247 3000 SLSRVS 3005
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1180-1479 |
9.13e-10 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 64.79 E-value: 9.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1180 PTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGITPTPQPItltPEQAQALGITPTPQ 1259
Cdd:pfam03154 180 AASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRL---PSPHPPLQPMTQPP 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1260 PITLTPEQtqalgitPTPQPITLTPeqaqalgITPTPQPITLTPEQVQALGitpTPQPITLTPEQAQALGitpTPQPITL 1339
Cdd:pfam03154 257 PPSQVSPQ-------PLPQPSLHGQ-------MPPMPHSLQTGPSHMQHPV---PPQPFPLTPQSSQSQV---PPGPSPA 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1340 TPEQAQALGITPTPQPITLTPEQTQALGITPTPQPIT-LTPEQAQALGITPTPQPITLTPELVqalGITPTPQPITLTPE 1418
Cdd:pfam03154 317 APGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPhIKPPPTTPIPQLPNPQSHKHPPHLS---GPSPFQMNSNLPPP 393
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907114282 1419 QA-QALGITPTPQPTTLSPEQAQALgitptPQPITLTPEQAQALGITPTPqptTLSPEQAQA 1479
Cdd:pfam03154 394 PAlKPLSSLSTHHPPSAHPPPLQLM-----PQSQQLPPPPAQPPVLTQSQ---SLPPPAASH 447
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2281-2626 |
5.03e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.17 E-value: 5.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 2281 QPAQAFPSPFTLEKPATLATSTDRLSQRWKDSYPASIPLQALRPSPTQAPFTPTTSLgigslldsekpwmsptyrqtltd 2360
Cdd:PHA03247 2642 PPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSL----------------------- 2698
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 2361 rgqdvlAQPLAPETPPSLRQLLAPGAPPTPGPPLGPRHFFKPrvpPTSGEVPGLVSGGSAAheelPMSRTTPLQPPEWQG 2440
Cdd:PHA03247 2699 ------ADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPA---LPAAPAPPAVPAGPAT----PGGPARPARPPTTAG 2765
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 2441 PSRLIPEQGfmPAISSIPLHPFTAEALPTPGRPQRSSKAKPLKPKSARGLPNVTLGFETSQA-PFPIEKTQIPKTPDTSE 2519
Cdd:PHA03247 2766 PPAPAPPAA--PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAgPLPPPTSAQPTAPPPPP 2843
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 2520 QTQALQDALG--VQPFGIF-------QPYGTSSGIARSQSPLIDEKALSREKPGTPLPSLTTQLPQTPQISTSEKGQ--- 2587
Cdd:PHA03247 2844 GPPPPSLPLGgsVAPGGDVrrrppsrSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQpqp 2923
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1907114282 2588 ------KPWLPPIDKPWTPTPVSSTREAKMIVSPTDQHPEDGYVV 2626
Cdd:PHA03247 2924 ppppqpQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968
|
|
| SP2_N |
cd22540 |
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ... |
1115-1466 |
1.76e-04 |
|
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.
Pssm-ID: 411776 [Multi-domain] Cd Length: 511 Bit Score: 46.84 E-value: 1.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1115 QTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQA 1194
Cdd:cd22540 122 TNQQYQISPQIQAAGQINNSGQIQIIPGTNQAIITPVQVLQQPQQAHKPVPIKPAPLQTSNTNSASLQVPGNVIKLQSGG 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1195 LGITPTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGITPTPQPitlTPEQAQALGITPTPQPI-----TLTPEQTQ 1269
Cdd:cd22540 202 NVALTLPVNNLVGTQDGATQLQLAAAPSKPSKKIRKKSAQAAQPAVT---VAEQVETVLIETTADNIiqagnNLLIVQSP 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1270 ALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQVQALGITP-----TPQPITLTPEQAQALGITPTPQPITLTPEQA 1344
Cdd:cd22540 279 GTGQPAVLQQVQVLQPKQEQQVVQIPQQALRVVQAASATLPTVPqkplqNIQIQNSEPTPTQVYIKTPSGEVQTVLLQEA 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1345 QALGITPTPQPITLTPEQTQALGiTPTPQPITLTPEQAQALGITPTPQPITLTPELVQALGITPTPQPITLTPEQAQALG 1424
Cdd:cd22540 359 PAATATPSSSTSTVQQQVTANNG-TGTSKPNYNVRKERTLPKIAPAGGIISLNAAQLAAAAQAIQTININGVQVQGVPVT 437
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1907114282 1425 ITPTPQPTTLSPEQAQALGIT---PTPQPITLTPEQAQALGITPT 1466
Cdd:cd22540 438 ITNAGGQQQLTVQTVSSNNLTisgLSPTQIQLQMEQALEIETQPG 482
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1079-1483 |
1.64e-15 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 83.83 E-value: 1.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1079 QALGITPTPQPITLTPEQAQALGITPTPQPTTLTPEQTQALGITPTPQPITLTPEQAQALGIT-PTPQPITLTPEQTQAL 1157
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAdPPPPPPTPEPAPHALV 2716
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1158 GITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPqPITLTPEQAQALGITPTPQPITLTPEQAQALGITP 1237
Cdd:PHA03247 2717 SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP-PTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESR 2795
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1238 TPQPITLTPEQAQALGITPTPqpiTLTPEQTQALGITPTPQPITLTPEQaqalgiTPTPQPITLTPEQVQALGITPTPQP 1317
Cdd:PHA03247 2796 ESLPSPWDPADPPAAVLAPAA---ALPPAASPAGPLPPPTSAQPTAPPP------PPGPPPPSLPLGGSVAPGGDVRRRP 2866
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1318 itlTPEQAQALGITPTPQPITLTPEQAqalgITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLT 1397
Cdd:PHA03247 2867 ---PSRSPAAKPAAPARPPVRRLARPA----VSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRP 2939
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1398 PelvqalgitPTPQPITLTPEQAQALGITPTPQPTTLSPEQaqalgitpTPQPITLTPEQAQALgitPTPQPTTLSPEQA 1477
Cdd:PHA03247 2940 Q---------PPLAPTTDPAGAGEPSGAVPQPWLGALVPGR--------VAVPRFRVPQPAPSR---EAPASSTPPLTGH 2999
|
....*.
gi 1907114282 1478 QALGIS 1483
Cdd:PHA03247 3000 SLSRVS 3005
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1085-1486 |
6.83e-15 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 81.91 E-value: 6.83e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1085 PTPQPITLTPEQAqaLGITPTPQPTTLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPQ 1164
Cdd:PHA03247 2569 PPPRPAPRPSEPA--VTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTV 2646
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1165 PITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGIT-PTPQPITLTPEQAQALGITPTPQPIT 1243
Cdd:PHA03247 2647 PPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAdPPPPPPTPEPAPHALVSATPLPPGPA 2726
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1244 LTPEQAQALGITPTPQPITLTPEQTQALGITPTPqPITLTPEQAQALGITPTPQPITLTPEQVQALGITPTPQPITLTPE 1323
Cdd:PHA03247 2727 AARQASPALPAAPAPPAVPAGPATPGGPARPARP-PTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPA 2805
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1324 QAQALGITPTPqpiTLTPEQAQALGITPTPQPITLTPEQTqalgitPTPQPITLTPEQAQALG----ITPTPQPITLTPE 1399
Cdd:PHA03247 2806 DPPAAVLAPAA---ALPPAASPAGPLPPPTSAQPTAPPPP------PGPPPPSLPLGGSVAPGgdvrRRPPSRSPAAKPA 2876
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1400 L--------VQALGITPTPQPITLTPEQAQALGITPTPQPTTLSPEQAQAlgitPTPQPITLTPEQAQalgitPTPQPTT 1471
Cdd:PHA03247 2877 AparppvrrLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPP----PQPQPPPPPPPRPQ-----PPLAPTT 2947
|
410
....*....|....*
gi 1907114282 1472 LSPEQAQALGISLIP 1486
Cdd:PHA03247 2948 DPAGAGEPSGAVPQP 2962
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1123-1500 |
3.62e-14 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 79.60 E-value: 3.62e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1123 PTPQPITLTPEQA-QALGITPTPQPITLTPeqtQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTP 1201
Cdd:PHA03247 2569 PPPRPAPRPSEPAvTSRARRPDAPPQSARP---RAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPT 2645
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1202 QPITLTPEQAQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGIT-PTPQPITLTPEQTQALGITPTPQPI 1280
Cdd:PHA03247 2646 VPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAdPPPPPPTPEPAPHALVSATPLPPGP 2725
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1281 TLTPEQAQALGITPTPQPITLTPEQVQALGITPTPqPITLTPEQAQALGITPTPQPITLTPEQAQALGITPTPQPITLTP 1360
Cdd:PHA03247 2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARP-PTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDP 2804
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1361 EQTQALGITPTPqpiTLTPEQAQALGITPTPQPITLTPELvqalgiTPTPQPITLTPEQAQALG---------ITPTPQP 1431
Cdd:PHA03247 2805 ADPPAAVLAPAA---ALPPAASPAGPLPPPTSAQPTAPPP------PPGPPPPSLPLGGSVAPGgdvrrrppsRSPAAKP 2875
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907114282 1432 TTLSPEQAQALG---ITPTPQPITLTPEQAQALGITPTPQPTTLSPEQAQALGISLIPKQQEISLSPEQAQA 1500
Cdd:PHA03247 2876 AAPARPPVRRLArpaVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTT 2947
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1180-1479 |
9.13e-10 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 64.79 E-value: 9.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1180 PTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGITPTPQPItltPEQAQALGITPTPQ 1259
Cdd:pfam03154 180 AASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRL---PSPHPPLQPMTQPP 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1260 PITLTPEQtqalgitPTPQPITLTPeqaqalgITPTPQPITLTPEQVQALGitpTPQPITLTPEQAQALGitpTPQPITL 1339
Cdd:pfam03154 257 PPSQVSPQ-------PLPQPSLHGQ-------MPPMPHSLQTGPSHMQHPV---PPQPFPLTPQSSQSQV---PPGPSPA 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1340 TPEQAQALGITPTPQPITLTPEQTQALGITPTPQPIT-LTPEQAQALGITPTPQPITLTPELVqalGITPTPQPITLTPE 1418
Cdd:pfam03154 317 APGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPhIKPPPTTPIPQLPNPQSHKHPPHLS---GPSPFQMNSNLPPP 393
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907114282 1419 QA-QALGITPTPQPTTLSPEQAQALgitptPQPITLTPEQAQALGITPTPqptTLSPEQAQA 1479
Cdd:pfam03154 394 PAlKPLSSLSTHHPPSAHPPPLQLM-----PQSQQLPPPPAQPPVLTQSQ---SLPPPAASH 447
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1078-1400 |
2.37e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 63.80 E-value: 2.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1078 AQALGITPTPQPITLTPEQAQALGITPTPQPTTLTPEQTQALGITPTPQPiTLTPEQAQALGITPTPQPITLTPEQTQAL 1157
Cdd:PHA03247 2732 SPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASLSESRESLPSPWDPADPPAA 2810
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1158 GITPTPqpiTLTPEQAQALGITPTPQPITLTPEQtqalgiTPTPQPITLTPEQAQALGITPTPQPitlTPEQAQALGITP 1237
Cdd:PHA03247 2811 VLAPAA---ALPPAASPAGPLPPPTSAQPTAPPP------PPGPPPPSLPLGGSVAPGGDVRRRP---PSRSPAAKPAAP 2878
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1238 TPQPITLTPEQAqalgITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQAlgitPTPQPITLTPEQVQalgitPTPQP 1317
Cdd:PHA03247 2879 ARPPVRRLARPA----VSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPP----PQPQPPPPPPPRPQ-----PPLAP 2945
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1318 ITLTPEQAQALGITPTPQPITLTPEQAQAL-GITPTPQPITLTPEQTQAlgiTPTPQPITLTPEQAQ--ALGITPTPQPI 1394
Cdd:PHA03247 2946 TTDPAGAGEPSGAVPQPWLGALVPGRVAVPrFRVPQPAPSREAPASSTP---PLTGHSLSRVSSWASslALHEETDPPPV 3022
|
....*.
gi 1907114282 1395 TLTPEL 1400
Cdd:PHA03247 3023 SLKQTL 3028
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1218-1507 |
5.52e-09 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 62.09 E-value: 5.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1218 PTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPQPItltPEQAQALGITPTPQ 1297
Cdd:pfam03154 180 AASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRL---PSPHPPLQPMTQPP 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1298 PITLTPEQvqalgitPTPQPITLTPeqaqalgITPTPQPITLTPEQAQALGitpTPQPITLTPEQTQALGitpTPQPITL 1377
Cdd:pfam03154 257 PPSQVSPQ-------PLPQPSLHGQ-------MPPMPHSLQTGPSHMQHPV---PPQPFPLTPQSSQSQV---PPGPSPA 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1378 TPEQAQALGITPTPQPITLTPELVQALGITPTPQPIT-LTPEQAQALGITPTPQPTTLSPEQAqalGITPTPQPITLTPE 1456
Cdd:pfam03154 317 APGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPhIKPPPTTPIPQLPNPQSHKHPPHLS---GPSPFQMNSNLPPP 393
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1907114282 1457 QAqalgITPTPQPTTLSPEQAQALGISLIPKQQEISLSPeqAQALGLTLTP 1507
Cdd:pfam03154 394 PA----LKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPP--AQPPVLTQSQ 438
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1009-1358 |
6.06e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 62.26 E-value: 6.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1009 PTPQPITFTPEQTQALGITPTPqlitLTPEQAKALANTLTAEQVSLSPQQAEALGITPTPQPTTLTP---EQAQALGITP 1085
Cdd:PHA03247 2701 PPPPPPTPEPAPHALVSATPLP----PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTagpPAPAPPAAPA 2776
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1086 TPQPITLTPEQAQALGITPTPQPTTLTPEQTQALGITPTP-QPITLTPEQAQALGITPTPQPITLTPEqtqalgitptPQ 1164
Cdd:PHA03247 2777 AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAaLPPAASPAGPLPPPTSAQPTAPPPPPG----------PP 2846
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1165 PITLTPEQAQALGITPTPQPitlTPEQTQALGITPTPQPITLTPEQAqalgITPTPQPITLTPEQAQALGITPTPQPITL 1244
Cdd:PHA03247 2847 PPSLPLGGSVAPGGDVRRRP---PSRSPAAKPAAPARPPVRRLARPA----VSRSTESFALPPDQPERPPQPQAPPPPQP 2919
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1245 TPEQAQAlgitPTPQPITLTPEQTQalgitPTPQPITLTPEQAQALGITPTPQPITLTPEQVQAL-GITPTPQPITLTPE 1323
Cdd:PHA03247 2920 QPQPPPP----PQPQPPPPPPPRPQ-----PPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPrFRVPQPAPSREAPA 2990
|
330 340 350
....*....|....*....|....*....|....*..
gi 1907114282 1324 QAQAlgiTPTPQPITLTPEQAQ--ALGITPTPQPITL 1358
Cdd:PHA03247 2991 SSTP---PLTGHSLSRVSSWASslALHEETDPPPVSL 3024
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1116-1475 |
1.49e-08 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 60.55 E-value: 1.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1116 TQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQAL 1195
Cdd:pfam03154 192 TQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSL 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1196 --GITPTPQPITLTPEQAQALGitpTPQPITLTPEQAQALGitpTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGI 1273
Cdd:pfam03154 272 hgQMPPMPHSLQTGPSHMQHPV---PPQPFPLTPQSSQSQV---PPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPL 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1274 TPTPQPIT-LTPEQAQALGITPTPQPITLTPeqvQALGITPTPQPITLTPEQA-QALGITPTPQPITLTPEQAQalgITP 1351
Cdd:pfam03154 346 PPAPLSMPhIKPPPTTPIPQLPNPQSHKHPP---HLSGPSPFQMNSNLPPPPAlKPLSSLSTHHPPSAHPPPLQ---LMP 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1352 TPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPELVQAlgitPTPQPITLTPEQAQALGITPTPQP 1431
Cdd:pfam03154 420 QSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGG----PPPITPPSGPPTSTSSAMPGIQPP 495
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1907114282 1432 TTLSPEQAQALGITPT----PQPITLTPEQAQALGITPTPQPTTLSPE 1475
Cdd:pfam03154 496 SSASVSSSGPVPAAVScplpPVQIKEEALDEAEEPESPPPPPRSPSPE 543
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
1114-1500 |
1.32e-06 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 53.81 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1114 EQTQALGITPTPQPITLTpEQAQALGITPTPQPITLTPEQTQAlgITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQ 1193
Cdd:pfam17823 56 EQ*NFCAATAAPAPVTLT-KGTSAAHLNSTEVTAEHTPHGTDL--SEPATREGAADGAASRALAAAASSSPSSAAQSLPA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1194 ALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGI 1273
Cdd:pfam17823 133 AIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGI 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1274 TpTPQPITLTPEQAQALGITPTPQPITLTPEQVqalgiTPTPQPITLTPEQAQALGITPTPQPITLTPEQAQalgitpTP 1353
Cdd:pfam17823 213 S-TAATATGHPAAGTALAAVGNSSPAAGTVTAA-----VGTVTPAALATLAAAAGTVASAAGTINMGDPHAR------RL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1354 QPITLTPEQTQALGITPTPQPitltpeQAQAlgitPTPQPITLTPELVQALGITPTPQPITLTPEQAQALGITPTPQPTT 1433
Cdd:pfam17823 281 SPAKHMPSDTMARNPAAPMGA------QAQG----PIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTT 350
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907114282 1434 lspEQAQALGITPTPQPITLTPEQAQALGITPTPQPTTLSPEQ-AQALGISLIPKQQEISLSPEQAQA 1500
Cdd:pfam17823 351 ---TKAQAKEPSASPVPVLHTSMIPEVEATSPTTQPSPLLPTQgAAGPGILLAPEQVATEATAGTASA 415
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1009-1393 |
1.14e-05 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 51.31 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1009 PTPQPITFTPEQTQALGITPTPQLITLTPEQAKALANTLTAEQVSLSPQQAEALGITPTPQPTTLTPEQAQALGITPTPQ 1088
Cdd:pfam03154 180 AASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPS 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1089 PITLTPEQAQALGITPTPQPTTLTPEQTQALGITPtPQPITLTPEQAQALGitpTPQPITLTPEQTQALGITPTPQPITL 1168
Cdd:pfam03154 260 QVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVP-PQPFPLTPQSSQSQV---PPGPSPAAPGQSQQRIHTPPSQSQLQ 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1169 TPEQAQALGITPTPQPIT-LTPEQTQALGITPTPQPITLTPEQAqalGITPTPQPITLTPEQA-QALGITPTPQPITLTP 1246
Cdd:pfam03154 336 SQQPPREQPLPPAPLSMPhIKPPPTTPIPQLPNPQSHKHPPHLS---GPSPFQMNSNLPPPPAlKPLSSLSTHHPPSAHP 412
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1247 EQAQalgITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPeqvqALGITPTPQPITLTPEQAQ 1326
Cdd:pfam03154 413 PPLQ---LMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHP----FVPGGPPPITPPSGPPTST 485
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907114282 1327 ALGITPTPQPITLTPEQAQALGITPTpqpITLTPEQTQALGITPTPQPITLTPEQAqalgiTPTPQP 1393
Cdd:pfam03154 486 SSAMPGIQPPSSASVSSSGPVPAAVS---CPLPPVQIKEEALDEAEEPESPPPPPR-----SPSPEP 544
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
1232-1498 |
3.51e-05 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 49.53 E-value: 3.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1232 ALGITPTPQPITLTPEQA----QALGITPTPQPITLTPeqtqALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQVQ 1307
Cdd:pfam05109 395 GLGTAPKTLIITRTATNAttttHKVIFSKAPESTTTSP----TLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVST 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1308 ALGITPTPQPITltpeqAQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQ---- 1383
Cdd:pfam05109 471 ADVTSPTPAGTT-----SGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKtspt 545
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1384 ALGITPTPQPITLTPELVqalgiTPTPQPITLTPEQAQALGITPTPQPTTLSPEQAQ----------ALGITPTPQPITL 1453
Cdd:pfam05109 546 SAVTTPTPNATSPTPAVT-----TPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGEtspqanttnhTLGGTSSTPVVTS 620
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1907114282 1454 TPEQAQALGITPTPQPTTLSPEQaqalgISLIPKQQEISLSPEQA 1498
Cdd:pfam05109 621 PPKNATSAVTTGQHNITSSSTSS-----MSLRPSSISETLSPSTS 660
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2281-2626 |
5.03e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.17 E-value: 5.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 2281 QPAQAFPSPFTLEKPATLATSTDRLSQRWKDSYPASIPLQALRPSPTQAPFTPTTSLgigslldsekpwmsptyrqtltd 2360
Cdd:PHA03247 2642 PPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSL----------------------- 2698
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 2361 rgqdvlAQPLAPETPPSLRQLLAPGAPPTPGPPLGPRHFFKPrvpPTSGEVPGLVSGGSAAheelPMSRTTPLQPPEWQG 2440
Cdd:PHA03247 2699 ------ADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPA---LPAAPAPPAVPAGPAT----PGGPARPARPPTTAG 2765
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 2441 PSRLIPEQGfmPAISSIPLHPFTAEALPTPGRPQRSSKAKPLKPKSARGLPNVTLGFETSQA-PFPIEKTQIPKTPDTSE 2519
Cdd:PHA03247 2766 PPAPAPPAA--PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAgPLPPPTSAQPTAPPPPP 2843
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 2520 QTQALQDALG--VQPFGIF-------QPYGTSSGIARSQSPLIDEKALSREKPGTPLPSLTTQLPQTPQISTSEKGQ--- 2587
Cdd:PHA03247 2844 GPPPPSLPLGgsVAPGGDVrrrppsrSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQpqp 2923
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1907114282 2588 ------KPWLPPIDKPWTPTPVSSTREAKMIVSPTDQHPEDGYVV 2626
Cdd:PHA03247 2924 ppppqpQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
1225-1488 |
6.32e-05 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 48.91 E-value: 6.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1225 LTPEQAQALGITPTPQPITLTPEQAQalgiTPTPQPitlTPEQTQALGITPTPQPITLTPEQaqalgiTPTP-QPITLTP 1303
Cdd:PHA03378 569 LGPLQIQPLTSPTTSQLASSAPSYAQ----TPWPVP---HPSQTPEPPTTQSHIPETSAPRQ------WPMPlRPIPMRP 635
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1304 EQVQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGITpTPQPITLTPEQTQALGITPTP-QPITLTPEQA 1382
Cdd:PHA03378 636 LRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGAN-TMLPIQWAPGTMQPPPRAPTPmRPPAAPPGRA 714
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1383 QALGITPTP-QPITLTPELVQALGITPTPQPitlTPEQAQALGITPTPQPTTLSPEQAQALGITPTPQPITLTPEQAQAL 1461
Cdd:PHA03378 715 QRPAAATGRaRPPAAAPGRARPPAAAPGRAR---PPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPR 791
|
250 260
....*....|....*....|....*..
gi 1907114282 1462 GiTPTPQPttlsPEQAQALGISLIPKQ 1488
Cdd:PHA03378 792 G-APTPQP----PPQAGPTSMQLMPRA 813
|
|
| SP2_N |
cd22540 |
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ... |
1115-1466 |
1.76e-04 |
|
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.
Pssm-ID: 411776 [Multi-domain] Cd Length: 511 Bit Score: 46.84 E-value: 1.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1115 QTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQA 1194
Cdd:cd22540 122 TNQQYQISPQIQAAGQINNSGQIQIIPGTNQAIITPVQVLQQPQQAHKPVPIKPAPLQTSNTNSASLQVPGNVIKLQSGG 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1195 LGITPTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGITPTPQPitlTPEQAQALGITPTPQPI-----TLTPEQTQ 1269
Cdd:cd22540 202 NVALTLPVNNLVGTQDGATQLQLAAAPSKPSKKIRKKSAQAAQPAVT---VAEQVETVLIETTADNIiqagnNLLIVQSP 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1270 ALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQVQALGITP-----TPQPITLTPEQAQALGITPTPQPITLTPEQA 1344
Cdd:cd22540 279 GTGQPAVLQQVQVLQPKQEQQVVQIPQQALRVVQAASATLPTVPqkplqNIQIQNSEPTPTQVYIKTPSGEVQTVLLQEA 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1345 QALGITPTPQPITLTPEQTQALGiTPTPQPITLTPEQAQALGITPTPQPITLTPELVQALGITPTPQPITLTPEQAQALG 1424
Cdd:cd22540 359 PAATATPSSSTSTVQQQVTANNG-TGTSKPNYNVRKERTLPKIAPAGGIISLNAAQLAAAAQAIQTININGVQVQGVPVT 437
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1907114282 1425 ITPTPQPTTLSPEQAQALGIT---PTPQPITLTPEQAQALGITPT 1466
Cdd:cd22540 438 ITNAGGQQQLTVQTVSSNNLTisgLSPTQIQLQMEQALEIETQPG 482
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1170-1512 |
8.63e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 45.31 E-value: 8.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1170 PEQAQALGITPTPQPITLTPEQTQALGITPTPQPITLTPEqaqALGITPTPQPIT----LTPEQAQALGITPTPQPITLT 1245
Cdd:PHA03247 2484 AEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDE---PVGEPVHPRMLTwirgLEELASDDAGDPPPPLPPAAP 2560
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1246 PeqAQALGITPTPQPITLTPE-QTQALGITPTPQPITLTPeqaQALGITPTPQPITLTPEQVQALGITPTPQPITLTPEQ 1324
Cdd:PHA03247 2561 P--AAPDRSVPPPRPAPRPSEpAVTSRARRPDAPPQSARP---RAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAA 2635
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1325 AQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGIT-PTPQPITLTPELVQA 1403
Cdd:PHA03247 2636 NEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAdPPPPPPTPEPAPHAL 2715
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1404 LGITPTPQPITLTPEQAQALGITPTPQPTTLSPeqaqALGITPTPQPITLTPeqAQALGITPTPQPTTLSPEQAQALGIS 1483
Cdd:PHA03247 2716 VSATPLPPGPAAARQASPALPAAPAPPAVPAGP----ATPGGPARPARPPTT--AGPPAPAPPAAPAAGPPRRLTRPAVA 2789
|
330 340
....*....|....*....|....*....
gi 1907114282 1484 LIPKQQEISLSPEQAQALGLTLTPQQAQV 1512
Cdd:PHA03247 2790 SLSESRESLPSPWDPADPPAAVLAPAAAL 2818
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
2426-2623 |
8.80e-04 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 45.07 E-value: 8.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 2426 PMSRTTPLQPPEWQGPSRL-IPEQGFMPAISSIPLHPFTAEALPTPGRPQRSSKAKPLKP-------------------- 2484
Cdd:PTZ00449 600 PRSAQRPTRPKSPKLPELLdIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPpkspkppfdpkfkekfyddy 679
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 2485 --KSARGLPNVTLgFETSQAPFPIEKTQIPKTPDTSEQT-QALQDALGVQPFGIFQPYGTSSGIARSQS----PLIDEKA 2557
Cdd:PTZ00449 680 ldAAAKSKETKTT-VVLDESFESILKETLPETPGTPFTTpRPLPPKLPRDEEFPFEPIGDPDAEQPDDIefftPPEEERT 758
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907114282 2558 LSREKPG-TPLPSLTTQLPQTPQIsTSEKGQKPwlPPIDKPWTPTPVSSTREAKMIVSPTDQHPEDG 2623
Cdd:PTZ00449 759 FFHETPAdTPLPDILAEEFKEEDI-HAETGEPD--EAMKRPDSPSEHEDKPPGDHPSLPKKRHRLDG 822
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2163-2593 |
1.45e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.54 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 2163 SPLTPKQPQAVEPAKAKL-----PPLTPSQAQPLQKQLAPELTQTLLFTITLQKAQHLGVTFTYEQTQAAAVTLTSEQVA 2237
Cdd:PHA03247 2678 SPPQRPRRRAARPTVGSLtsladPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARP 2757
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 2238 ALEDALTENLAwrweiSVTPGMAQEAPNITTTKQLQALGITARQPAQAFPSPFTLEKPATLATSTDRLSQRWKDSYPASI 2317
Cdd:PHA03247 2758 ARPPTTAGPPA-----PAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPT 2832
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 2318 PLQALRPSPTQAPFTPTTSLGiGSLLDSEKPWMSPTYRQTltdrgqdvLAQPLAPETPPSLRqllapgaPPTPGPPLGPR 2397
Cdd:PHA03247 2833 SAQPTAPPPPPGPPPPSLPLG-GSVAPGGDVRRRPPSRSP--------AAKPAAPARPPVRR-------LARPAVSRSTE 2896
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 2398 HFFKPRVPPTSGEVPGLVSGGSAAHEELPMSRTTPLQPPEWQGPSRLIPEQGFMPAISSIPLHPFTAEALPTPGR----- 2472
Cdd:PHA03247 2897 SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRvavpr 2976
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 2473 -------PQRSSKAKPLKPKSARGLPNVT-----LGFETSQAPFPIEKTQIPKTPDTSEQTQAlqdalgvqpfgifqpyg 2540
Cdd:PHA03247 2977 frvpqpaPSREAPASSTPPLTGHSLSRVSswassLALHEETDPPPVSLKQTLWPPDDTEDSDA----------------- 3039
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 1907114282 2541 tsSGIARSQSPLIDEKALSREKPGTPLPSLTTQLPQTPQISTSEKGQKPWLPP 2593
Cdd:PHA03247 3040 --DSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPP 3090
|
|
| PRK14948 |
PRK14948 |
DNA polymerase III subunit gamma/tau; |
1119-1356 |
2.13e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237862 [Multi-domain] Cd Length: 620 Bit Score: 43.41 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1119 LGITPTPQPitltPEQAQALGITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGIT 1198
Cdd:PRK14948 357 LGLLPSAFI----SEIANASAPANPTPAPNPSPPPAPIQPSAPKTKQAATTPSPPPAKASPPIPVPAEPTEPSPTPPANA 432
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1199 PTPQPITLTPEQAQA-LGITPTPQPITLTPEQAQALGITPTPQPITLTP-------------EQA--QALGitptpQPIT 1262
Cdd:PRK14948 433 ANAPPSLNLEELWQQiLAKLELPSTRMLLSQQAELVSLDSNRAVIAVSPnwlgmvqsrkpllEQAfaKVLG-----RSIK 507
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1263 LTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPeqvqALGITPTPQPITLTPEQAQALGITPTPQPITLTPE 1342
Cdd:PRK14948 508 LNLESQSGSASNTAKTPPPPQKSPPPPAPTPPLPQPTATAP----PPTPPPPPPTATQASSNAPAQIPADSSPPPPIPEE 583
|
250
....*....|....
gi 1907114282 1343 QAQALGITPTPQPI 1356
Cdd:PRK14948 584 PTPSPTKDSSPEEI 597
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
1023-1433 |
3.01e-03 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 43.37 E-value: 3.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1023 ALGITPTPQLITLTPEQAkalanTLTAEQVSLSpqqaealgitptpqPTTLTPEQAQALGITPTPQPITLTPEQAQALGI 1102
Cdd:pfam05109 395 GLGTAPKTLIITRTATNA-----TTTTHKVIFS--------------KAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVP 455
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1103 TPTPQPTTLTPEQTQALGITPTPQPITltpeqAQALGITPTPQPI-----TLTPEQTQALGITPTPQPITLTPEQAQAlg 1177
Cdd:pfam05109 456 TNLTAPASTGPTVSTADVTSPTPAGTT-----SGASPVTPSPSPRdngteSKAPDMTSPTSAVTTPTPNATSPTPAVT-- 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1178 iTPTPQPITLTPEQTQALGITPTPQPITLTPEQAQAlgiTPTPQPITLTPEQAQALGITPTPQPITLTPEQAQAlgitpT 1257
Cdd:pfam05109 529 -TPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVT---TPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGET-----S 599
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1258 PQPITltpeQTQALGITPTPQPITLTPEQAQAlgiTPTPQPITLTPEQVQALGITPTPQPITLTPEQAQAlgiTPTPQPI 1337
Cdd:pfam05109 600 PQANT----TNHTLGGTSSTPVVTSPPKNATS---AVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDN---STSHMPL 669
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1338 TLTPEQAQALGITptpqpiTLTPEQTQALGI-TPTPQPITLTPEQAQALGITPTpqpiTLTPELVQALGITPtpqPITLT 1416
Cdd:pfam05109 670 LTSAHPTGGENIT------QVTPASTSTHHVsTSSPAPRPGTTSQASGPGNSST----STKPGEVNVTKGTP---PKNAT 736
|
410
....*....|....*..
gi 1907114282 1417 PEQAQALGITPTPQPTT 1433
Cdd:pfam05109 737 SPQAPSGQKTAVPTVTS 753
|
|
| PRK14948 |
PRK14948 |
DNA polymerase III subunit gamma/tau; |
1114-1337 |
3.12e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237862 [Multi-domain] Cd Length: 620 Bit Score: 43.03 E-value: 3.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1114 EQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQ 1193
Cdd:PRK14948 367 EIANASAPANPTPAPNPSPPPAPIQPSAPKTKQAATTPSPPPAKASPPIPVPAEPTEPSPTPPANAANAPPSLNLEELWQ 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1194 A-LGITPTPQPITLTPEQAQALGITPTPQPITLTP-------------EQA--QALGitptpQPITLTPEQAQALGITPT 1257
Cdd:PRK14948 447 QiLAKLELPSTRMLLSQQAELVSLDSNRAVIAVSPnwlgmvqsrkpllEQAfaKVLG-----RSIKLNLESQSGSASNTA 521
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1258 PQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQVQAlgitPTPQPITLTPEQAQALGITPTPQPI 1337
Cdd:PRK14948 522 KTPPPPQKSPPPPAPTPPLPQPTATAPPPTPPPPPPTATQASSNAPAQIPA----DSSPPPPIPEEPTPSPTKDSSPEEI 597
|
|
| PRK14948 |
PRK14948 |
DNA polymerase III subunit gamma/tau; |
1271-1497 |
7.35e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237862 [Multi-domain] Cd Length: 620 Bit Score: 41.87 E-value: 7.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1271 LGITPTPQPitltPEQAQALGITPTPQPITLTPEQVQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGIT 1350
Cdd:PRK14948 357 LGLLPSAFI----SEIANASAPANPTPAPNPSPPPAPIQPSAPKTKQAATTPSPPPAKASPPIPVPAEPTEPSPTPPANA 432
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1351 PTPQPITLTPEQTQA-LGITPTPQPITLTPEQAQALGITPTPQPITLTPELV---------------QALGitptpQPIT 1414
Cdd:PRK14948 433 ANAPPSLNLEELWQQiLAKLELPSTRMLLSQQAELVSLDSNRAVIAVSPNWLgmvqsrkplleqafaKVLG-----RSIK 507
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1415 LTPEQAQALGITPTPQPTTLSPEQAQALGITPTPQPITLTPEQAQALGITPTPQPTTLSPEQAQALGISLIPKQQEISLS 1494
Cdd:PRK14948 508 LNLESQSGSASNTAKTPPPPQKSPPPPAPTPPLPQPTATAPPPTPPPPPPTATQASSNAPAQIPADSSPPPPIPEEPTPS 587
|
...
gi 1907114282 1495 PEQ 1497
Cdd:PRK14948 588 PTK 590
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
924-1344 |
8.44e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 41.68 E-value: 8.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 924 GLPLIPPKPITFTreqTQALGITPTHQPITLTSEqvqalGITPTHQPITLTPEQAQALALILTTEQVKTQRInlsPDQTQ 1003
Cdd:pfam03154 179 GAASPPSPPPPGT---TQAATAGPTPSAPSVPPQ-----GSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRL---PSPHP 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1004 ALGITPTPQPITFTPEQTqalgiTPTPQLITLTPEQAKALANTLTAEQVSLSPQqaealgitptPQPTTLTPEQAQalgI 1083
Cdd:pfam03154 248 PLQPMTQPPPPSQVSPQP-----LPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQ----------PFPLTPQSSQSQ---V 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1084 TPTPQPITLTPEQAQALGITPTPQPTTLTPEQTQALGITPTPQPiTLTPEQAQALGITPTPQPITLTPEQTqalGITPTP 1163
Cdd:pfam03154 310 PPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMP-HIKPPPTTPIPQLPNPQSHKHPPHLS---GPSPFQ 385
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1164 QPITLTPEQA-QALGITPTPQPITLTPEQTQALgitptPQPITLTPEQAQALGITPTPqpiTLTPEQAQAlgitPTPQPI 1242
Cdd:pfam03154 386 MNSNLPPPPAlKPLSSLSTHHPPSAHPPPLQLM-----PQSQQLPPPPAQPPVLTQSQ---SLPPPAASH----PPTSGL 453
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114282 1243 TLTPEQ---AQALGITPTPQPIT--LTPEQTQALGITPTPQPITLTPEQAQALGITPTpqpITLTPEQVQALGITPTPQP 1317
Cdd:pfam03154 454 HQVPSQspfPQHPFVPGGPPPITppSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVS---CPLPPVQIKEEALDEAEEP 530
|
410 420
....*....|....*....|....*...
gi 1907114282 1318 ITLTPEQAqalgiTPTPQP-ITLTPEQA 1344
Cdd:pfam03154 531 ESPPPPPR-----SPSPEPtVVNTPSHA 553
|
|
| |
