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Conserved domains on  [gi|1907100150|ref|XP_036014423|]
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peptide chain release factor 1, mitochondrial isoform X2 [Mus musculus]

Protein Classification

peptide chain release factor 1( domain architecture ID 1907968)

peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA

CATH:  3.30.160.20|3.30.70.1660|1.10.287.4000
Gene Ontology:  GO:0003747|GO:0016149
SCOP:  4002864|4002570

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrfA super family cl43066
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 116-417 1.32e-128

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


The actual alignment was detected with superfamily member COG0216:

Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 375.11  E-value: 1.32e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 116 RALHRRHAQLAPLAAVYQEIQEAEQAIEELESLcksLNKQDEKQLQELVSEERQIIDQKIHRLYSELLERLVPKEKYDWS 195
Cdd:COG0216    33 RKLSKEYAELEPIVEAYREYKKLLEDIEEAKEL---LEEESDPEMREMAKEELEELEARLEELEEELKILLLPKDPNDDK 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 196 DVILEVTSGrtTGGD---IcqqFTREIFDMYQNYSYYKHWKFELLNYTPADYGGLHHAAARISGDSVYKHLKYEGGIHRV 272
Cdd:COG0216   110 NVILEIRAG--TGGDeaaL---FAGDLFRMYSRYAERKGWKVEILSASEGELGGYKEVIFRISGEGVYSRLKFESGVHRV 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 273 QRIPEV---GlssrmqRIHTGTMSVIVLPQPDEVtspgqDVKVDPKDLRVDTFRARGAGGQHVNTTDSAVRLVHIPTGLV 349
Cdd:COG0216   185 QRVPETesqG------RIHTSAATVAVLPEAEEV-----DVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIV 253

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907100150 350 VECQQERSQLKNKEIALRVLRARLYQQIIEKDRCQQQNARKLQVGTRAQSERIRTYNFTQDRVTDHRI 417
Cdd:COG0216   254 VECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 116-417 1.32e-128

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 375.11  E-value: 1.32e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 116 RALHRRHAQLAPLAAVYQEIQEAEQAIEELESLcksLNKQDEKQLQELVSEERQIIDQKIHRLYSELLERLVPKEKYDWS 195
Cdd:COG0216    33 RKLSKEYAELEPIVEAYREYKKLLEDIEEAKEL---LEEESDPEMREMAKEELEELEARLEELEEELKILLLPKDPNDDK 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 196 DVILEVTSGrtTGGD---IcqqFTREIFDMYQNYSYYKHWKFELLNYTPADYGGLHHAAARISGDSVYKHLKYEGGIHRV 272
Cdd:COG0216   110 NVILEIRAG--TGGDeaaL---FAGDLFRMYSRYAERKGWKVEILSASEGELGGYKEVIFRISGEGVYSRLKFESGVHRV 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 273 QRIPEV---GlssrmqRIHTGTMSVIVLPQPDEVtspgqDVKVDPKDLRVDTFRARGAGGQHVNTTDSAVRLVHIPTGLV 349
Cdd:COG0216   185 QRVPETesqG------RIHTSAATVAVLPEAEEV-----DVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIV 253

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907100150 350 VECQQERSQLKNKEIALRVLRARLYQQIIEKDRCQQQNARKLQVGTRAQSERIRTYNFTQDRVTDHRI 417
Cdd:COG0216   254 VECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321
prfA PRK00591
peptide chain release factor 1; Validated
 116-428 5.57e-126

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 368.64  E-value: 5.57e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 116 RALHRRHAQLAPLAAVYQEIQEAEQAIEELESLcksLNKQDEKQLQELVSEERQIIDQKIHRLYSELLERLVPKEKYDWS 195
Cdd:PRK00591   35 RKLSKEYAELEPIVEAYREYKQAQEDLEEAKEM---LEEESDPEMREMAKEELKELEERLEELEEELKILLLPKDPNDDK 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 196 DVILEVTSGrtTGGDICQQFTREIFDMYQNYSYYKHWKFELLNYTPADYGGLHHAAARISGDSVYKHLKYEGGIHRVQRI 275
Cdd:PRK00591  112 NVILEIRAG--TGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGYKEVIAEISGDGVYSKLKFESGVHRVQRV 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 276 PEV---GlssrmqRIHTGTMSVIVLPQPDEVtspgqDVKVDPKDLRVDTFRARGAGGQHVNTTDSAVRLVHIPTGLVVEC 352
Cdd:PRK00591  190 PATesqG------RIHTSAATVAVLPEAEEV-----EVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVEC 258

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907100150 353 QQERSQLKNKEIALRVLRARLYQQIIEKDRCQQQNARKLQVGTRAQSERIRTYNFTQDRVTDHRIAYevrdiKLYR 428
Cdd:PRK00591  259 QDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDHRINL-----TLYK 329
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 85-419 5.06e-107

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 320.49  E-value: 5.06e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150  85 KALQKYMEDLNKEYQTLDQCLQG--ISENEGDRRALHRRHAQLAPLAAVYQEIQEAEQAIEELESLCKSlnkqDEKQLQE 162
Cdd:TIGR00019   3 PSLLEKLESLLERYEELEALLSDpeVISDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILEE----SDPEMRE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 163 LVSEERQIIDQKIHRLYSELLERLVPKEKYDWSDVILEVTSGrtTGGDICQQFTREIFDMYQNYSYYKHWKFELLNYTPA 242
Cdd:TIGR00019  79 MAKEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAG--TGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANET 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 243 DYGGLHHAAARISGDSVYKHLKYEGGIHRVQRIPEvglSSRMQRIHTGTMSVIVLPQPDEVtspgqDVKVDPKDLRVDTF 322
Cdd:TIGR00019 157 ELGGYKEVIAEIKGDGVYSRLKFESGVHRVQRVPV---TESQGRIHTSAATVAVMPELEEV-----EVDINPADLRIDTF 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 323 RARGAGGQHVNTTDSAVRLVHIPTGLVVECQQERSQLKNKEIALRVLRARLYQQIIEKDRCQQQNARKLQVGTRAQSERI 402
Cdd:TIGR00019 229 RSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERI 308

                         330
                  ....*....|....*..
gi 1907100150 403 RTYNFTQDRVTDHRIAY 419
Cdd:TIGR00019 309 RTYNFPQNRVTDHRINL 325
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 94-294 1.37e-59

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 192.60  E-value: 1.37e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150  94 LNKEYQTLDQCLQ--GISENEGDRRALHRRHAQLAPLAAVYQEIQEAEQAIEELESLCKslnkqdEKQLQELVSEERQII 171
Cdd:pfam03462   1 LEERYEELEALLSdpDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE------DPELAELAEEELEEL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 172 DQKIHRLYSELLERLVPKEKYDWSDVILEVTSGrtTGGDICQQFTREIFDMYQNYSYYKHWKFELLNYTPADYGGLHHAA 251
Cdd:pfam03462  75 EKRLEELEEELKLLLLPKDPNDDKNAILEIRAG--AGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEAT 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1907100150 252 ARISGDSVYKHLKYEGGIHRVQRIPEvglSSRMQRIHTGTMSV 294
Cdd:pfam03462 153 FEISGEGAYGRLKFESGVHRVQRVPP---TESQGRIHTSFATV 192
PCRF smart00937
This domain is found in peptide chain release factors;
150-266 1.18e-31

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 116.79  E-value: 1.18e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150  150 KSLNKQDEKQLQELVSEERQII-DQKIHRLYSELLERLVPKEKYDWSDVILEVTSGrtTGGDICQQFTREIFDMYQNYSY 228
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELeAELEEELEELLKLLLLPKDPNDDKNAILEIRAG--AGGDEAALFAGDLLRMYLRYAE 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1907100150  229 YKHWKFELLNYTPADYGGLHHAAARISGDSVYKHLKYE 266
Cdd:smart00937  79 RKGWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 116-417 1.32e-128

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 375.11  E-value: 1.32e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 116 RALHRRHAQLAPLAAVYQEIQEAEQAIEELESLcksLNKQDEKQLQELVSEERQIIDQKIHRLYSELLERLVPKEKYDWS 195
Cdd:COG0216    33 RKLSKEYAELEPIVEAYREYKKLLEDIEEAKEL---LEEESDPEMREMAKEELEELEARLEELEEELKILLLPKDPNDDK 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 196 DVILEVTSGrtTGGD---IcqqFTREIFDMYQNYSYYKHWKFELLNYTPADYGGLHHAAARISGDSVYKHLKYEGGIHRV 272
Cdd:COG0216   110 NVILEIRAG--TGGDeaaL---FAGDLFRMYSRYAERKGWKVEILSASEGELGGYKEVIFRISGEGVYSRLKFESGVHRV 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 273 QRIPEV---GlssrmqRIHTGTMSVIVLPQPDEVtspgqDVKVDPKDLRVDTFRARGAGGQHVNTTDSAVRLVHIPTGLV 349
Cdd:COG0216   185 QRVPETesqG------RIHTSAATVAVLPEAEEV-----DVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIV 253

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907100150 350 VECQQERSQLKNKEIALRVLRARLYQQIIEKDRCQQQNARKLQVGTRAQSERIRTYNFTQDRVTDHRI 417
Cdd:COG0216   254 VECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321
prfA PRK00591
peptide chain release factor 1; Validated
 116-428 5.57e-126

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 368.64  E-value: 5.57e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 116 RALHRRHAQLAPLAAVYQEIQEAEQAIEELESLcksLNKQDEKQLQELVSEERQIIDQKIHRLYSELLERLVPKEKYDWS 195
Cdd:PRK00591   35 RKLSKEYAELEPIVEAYREYKQAQEDLEEAKEM---LEEESDPEMREMAKEELKELEERLEELEEELKILLLPKDPNDDK 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 196 DVILEVTSGrtTGGDICQQFTREIFDMYQNYSYYKHWKFELLNYTPADYGGLHHAAARISGDSVYKHLKYEGGIHRVQRI 275
Cdd:PRK00591  112 NVILEIRAG--TGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGYKEVIAEISGDGVYSKLKFESGVHRVQRV 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 276 PEV---GlssrmqRIHTGTMSVIVLPQPDEVtspgqDVKVDPKDLRVDTFRARGAGGQHVNTTDSAVRLVHIPTGLVVEC 352
Cdd:PRK00591  190 PATesqG------RIHTSAATVAVLPEAEEV-----EVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVEC 258

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907100150 353 QQERSQLKNKEIALRVLRARLYQQIIEKDRCQQQNARKLQVGTRAQSERIRTYNFTQDRVTDHRIAYevrdiKLYR 428
Cdd:PRK00591  259 QDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDHRINL-----TLYK 329
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 85-419 5.06e-107

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 320.49  E-value: 5.06e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150  85 KALQKYMEDLNKEYQTLDQCLQG--ISENEGDRRALHRRHAQLAPLAAVYQEIQEAEQAIEELESLCKSlnkqDEKQLQE 162
Cdd:TIGR00019   3 PSLLEKLESLLERYEELEALLSDpeVISDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILEE----SDPEMRE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 163 LVSEERQIIDQKIHRLYSELLERLVPKEKYDWSDVILEVTSGrtTGGDICQQFTREIFDMYQNYSYYKHWKFELLNYTPA 242
Cdd:TIGR00019  79 MAKEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAG--TGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANET 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 243 DYGGLHHAAARISGDSVYKHLKYEGGIHRVQRIPEvglSSRMQRIHTGTMSVIVLPQPDEVtspgqDVKVDPKDLRVDTF 322
Cdd:TIGR00019 157 ELGGYKEVIAEIKGDGVYSRLKFESGVHRVQRVPV---TESQGRIHTSAATVAVMPELEEV-----EVDINPADLRIDTF 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 323 RARGAGGQHVNTTDSAVRLVHIPTGLVVECQQERSQLKNKEIALRVLRARLYQQIIEKDRCQQQNARKLQVGTRAQSERI 402
Cdd:TIGR00019 229 RSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERI 308

                         330
                  ....*....|....*..
gi 1907100150 403 RTYNFTQDRVTDHRIAY 419
Cdd:TIGR00019 309 RTYNFPQNRVTDHRINL 325
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 128-424 4.28e-66

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 215.41  E-value: 4.28e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 128 LAAVYQEIQEAEQAIEELESLCKSLNKQDEKQLQELVSEERQIIDQKihrlYSELLERLVPKEKYDWSDVILEVTSGrtT 207
Cdd:TIGR00020  61 LEAVLDTLEELKNSLEDLSELLELAVEEDDEETFNELDAELKALEKK----LAELELRTMLSGEYDANNAYLTIQAG--A 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 208 GGDICQQFTREIFDMYQNYSYYKHWKFELLNYTPADYGGLHHAAARISGDSVYKHLKYEGGIHRVQRIPEVGLSSRMqri 287
Cdd:TIGR00020 135 GGTEAQDWASMLYRMYLRWAERRGFKVEIIDYSEGEEAGIKSVTILIKGPYAYGYLKSEQGVHRLVRISPFDANGRR--- 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 288 HTGTMSVIVLPQPDEVTspgqDVKVDPKDLRVDTFRARGAGGQHVNTTDSAVRLVHIPTGLVVECQQERSQLKNKEIALR 367
Cdd:TIGR00020 212 HTSFASVFVMPEVDDDI----DIEIKPEDLRIDTYRASGAGGQHVNKTDSAVRITHIPTGIVVQCQNDRSQHKNKDSAMK 287

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 368 VLRARLYQQIIEKDRC--QQQNARKLQVGTRAQserIRTYNF-TQDRVTDHRIAYEVRDI 424
Cdd:TIGR00020 288 VLKAKLYELEMEKEQAekDAKEGEKSEIGWGSQ---IRSYVLhPYSMVKDLRTGYETGNV 344
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 94-294 1.37e-59

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 192.60  E-value: 1.37e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150  94 LNKEYQTLDQCLQ--GISENEGDRRALHRRHAQLAPLAAVYQEIQEAEQAIEELESLCKslnkqdEKQLQELVSEERQII 171
Cdd:pfam03462   1 LEERYEELEALLSdpDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE------DPELAELAEEELEEL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 172 DQKIHRLYSELLERLVPKEKYDWSDVILEVTSGrtTGGDICQQFTREIFDMYQNYSYYKHWKFELLNYTPADYGGLHHAA 251
Cdd:pfam03462  75 EKRLEELEEELKLLLLPKDPNDDKNAILEIRAG--AGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEAT 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1907100150 252 ARISGDSVYKHLKYEGGIHRVQRIPEvglSSRMQRIHTGTMSV 294
Cdd:pfam03462 153 FEISGEGAYGRLKFESGVHRVQRVPP---TESQGRIHTSFATV 192
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 309-416 5.74e-56

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 180.31  E-value: 5.74e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 309 DVKVDPKDLRVDTFRARGAGGQHVNTTDSAVRLVHIPTGLVVECQQERSQLKNKEIALRVLRARLYQqiIEKDRCQQQNA 388
Cdd:pfam00472   4 EIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYE--LEEEKEEEKKR 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 1907100150 389 R-KLQVGTRAQSERIRTYNFT-QDRVTDHR 416
Cdd:pfam00472  82 RiKSQVGSGDRSEQIRTYNFKpQSRVKDHR 111
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 139-424 1.02e-52

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 179.23  E-value: 1.02e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 139 EQAIEELESLCKSLNKQDEKQLQELVSEERQIiDQKIHRLYSELLErlvpKEKYDWSDVILEVTSGrtTGGDICQQFTRE 218
Cdd:PRK05589   34 RNRIEDIEVLCEMMSEEDDEMKKEIISEVKNI-KEEIDRFKIETLL----SGEYDRNNAILTLHSG--VGGTDAQDWTEM 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 219 IFDMYQNYSYYKHWKFELLNYTPADYGGLHHAAARISGDSVYKHLKYEGGIHRVQRIPEVGLSSRMQrihTGTMSVIVLP 298
Cdd:PRK05589  107 LLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEKGIHRLVRISPFNANGKRQ---TSFASVEVLP 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 299 qpdEVTSpGQDVKVDPKDLRVDTFRARGAGGQHVNTTDSAVRLVHIPTGLVVECQQERSQLKNKEIALRVLRARLyqqiI 378
Cdd:PRK05589  184 ---ELTD-DQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHSNKETAMKMLKSKL----V 255

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907100150 379 E-KDRCQQQNARKL--QVGTRAQSERIRTYNF-TQDRVTDHRIAYEVRDI 424
Cdd:PRK05589  256 ElKERAHKEKIEDLtgELKDMGWGSQIRSYVFhPYNLVKDHRTGVETSNV 305
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 128-425 2.03e-50

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 172.92  E-value: 2.03e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 128 LAAVYQEIQEAEQAIEELESlckslnKQDEKQLQELVSeerqiiDQKIHRLYSELLE--RLVPKEkYDWSDVILEVTSGr 205
Cdd:PRK08787    9 IADVLSGLADAGELLDLAES------EQDEDTALAVIA------DLDKYQAHVEKLEfqRMFSGQ-MDGANAFVDIQAG- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 206 tTGGDICQQFTREIFDMYQNYSYYKHWKFELLNYTPADYGGLHHAAARISGDSVYKHLKYEGGIHRVQRIPEVGLSSRMq 285
Cdd:PRK08787   75 -AGGTEAQDWAEILLRMYLRWAESRGWKTELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRR- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 286 riHTGTMSVIVLPQPDEvtspGQDVKVDPKDLRVDTFRARGAGGQHVNTTDSAVRLVHIPTGLVVECQQERSQLKNKEIA 365
Cdd:PRK08787  153 --HTSFTSVFVSPEVDD----NIEIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNA 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907100150 366 LRVLRARLYQQIIEKDRCQQQ--NARKLQVGTRAQserIRTYNFTQDRVTDHRIAYEVRDIK 425
Cdd:PRK08787  227 MKMLAAKLYELEVQKRNAEKDalEATKSDIGWGSQ---IRNYVLDQSRIKDLRTGIERSDTQ 285
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 107-425 6.01e-46

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 161.44  E-value: 6.01e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 107 GISENEGDRRALHRRHAQLAPLAAVYQEIQEAEQAIEELESLCKSlnKQDEKQLQELVSEERQIIDQkihrlYSELLERL 186
Cdd:PRK06746    5 GFWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKE--EYDEDLHEELESEVKGLIQE-----MNEYELQL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 187 VPKEKYDWSDVILEVTSGrtTGGDICQQFTREIFDMYQNYSYYKHWKFELLNYTPADYGGLHHAAARISGDSVYKHLKYE 266
Cdd:PRK06746   78 LLSDPYDKNNAILELHPG--AGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 267 GGIHRVQRIPEVGLSSRMqriHTGTMSVIVLPQ-PDEVtspgqDVKVDPKDLRVDTFRARGAGGQHVNTTDSAVRLVHIP 345
Cdd:PRK06746  156 KGVHRLVRISPFDSSGRR---HTSFVSCEVVPEfNDEV-----EIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTP 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 346 TGLVVECQQERSQLKNKEIALRVLRARLYQQIIEKDRCQQQNARKLQ--VGTRAQserIRTYNF-TQDRVTDHRIAYEVR 422
Cdd:PRK06746  228 TNTVVTCQSERSQIKNREHAMKMLKAKLYQKKLEEQQAELDEIRGEQkeIGWGSQ---IRSYVFhPYSLVKDHRTNTEVG 304


                  ...
gi 1907100150 423 DIK 425
Cdd:PRK06746  305 NVQ 307
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 92-405 2.89e-45

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 160.04  E-value: 2.89e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150  92 EDLNKEYQTLDQCLQGIsenegdrRALHRRHAQLAPLAAVYQE------IQEAEQAIEELEslckslNKQDEKQLQELVS 165
Cdd:PRK07342   16 QKLMRERQQLDDSINGI-------NHLEQTLNDNIELIAMGEEegdksiVEDAEKTIRDLK------DEIDRRQIDALLS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 166 EERqiidqkihrlysellerlvpkekyDWSDVILEVTSGrtTGGDICQQFTREIFDMYQNYSYYKHWKFELLNYTPADYG 245
Cdd:PRK07342   83 GEA------------------------DANDTYLEVHAG--AGGTESQDWASMLLRMYTRWAERQGRKVEVLEVHDGEEA 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 246 GLHHAAARISGDSVYKHLKYEGGIHRVQRIPEVGLSSRMqriHTGTMSVIVLPQPDEVTspgqDVKVDPKDLRVDTFRAR 325
Cdd:PRK07342  137 GIKSATILVKGHNAYGWLKTESGVHRLVRISPYDSNARR---HTSFASIWVYPVIDDNI----EVDVNESDVRIDTYRSS 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 326 GAGGQHVNTTDSAVRLVHIPTGLVVECQQERSQLKNKEIALRVLRARLYQQIIEK--DRCQQQNARKLQVGTRAQserIR 403
Cdd:PRK07342  210 GAGGQHVNTTDSAVRITHIPTGIVVQCQQERSQHKNRAKAWSMLRARLYEEELKKreEATNAAAASKTDIGWGHQ---IR 286


                  ..
gi 1907100150 404 TY 405
Cdd:PRK07342  287 SY 288
PCRF smart00937
This domain is found in peptide chain release factors;
150-266 1.18e-31

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 116.79  E-value: 1.18e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150  150 KSLNKQDEKQLQELVSEERQII-DQKIHRLYSELLERLVPKEKYDWSDVILEVTSGrtTGGDICQQFTREIFDMYQNYSY 228
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELeAELEEELEELLKLLLLPKDPNDDKNAILEIRAG--AGGDEAALFAGDLLRMYLRYAE 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1907100150  229 YKHWKFELLNYTPADYGGLHHAAARISGDSVYKHLKYE 266
Cdd:smart00937  79 RKGWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 309-402 1.25e-31

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 117.54  E-value: 1.25e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 309 DVKVDPKDLRVDTFRARGAGGQHVNTTDSAVRLVH------------IPTGLVVECQQERSQLKNKEIALRVLRARLYQQ 376
Cdd:COG1186    20 EIEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLYEA 99

                          90       100
                  ....*....|....*....|....*.
gi 1907100150 377 IIEKdrcqqQNARKLQVgTRAQSERI 402
Cdd:COG1186   100 ELEP-----KERRATKP-TRGSKKRR 119
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 314-389 1.33e-18

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 83.67  E-value: 1.33e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907100150 314 PKDLRVDTFRARGAGGQHVNTTDSAVRLVHIPTGLVVECQQERSQLKNKEIALRVLRARLYQQIIEKDRCQQQNAR 389
Cdd:TIGR03072 105 EDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANKRLATLLLAVRLADLQQEQAAALRAERR 180
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
308-373 2.65e-08

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 52.46  E-value: 2.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100150 308 QDVKVDPKDLRVDTFRARGAGGQHVNTTDSAVRLV------HIP---------------TG---LVVECQQERSQLKNKE 363
Cdd:PRK09256    6 RRLVIPENELEWRFIRASGPGGQNVNKVSTAVELRfdiaasSLPefykerllalaghriTKdgvIVIKAQEFRSQERNRE 85

                          90
                  ....*....|
gi 1907100150 364 IAlrvlRARL 373
Cdd:PRK09256   86 DA----LERL 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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