Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250  13 VFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNkvVMNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVA 92
Cdd:COG5184   119 VWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG--VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVG 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250  93 ALQGirVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDrIIEIAAchSAHTSAAKTQGGHVY 172
Cdd:COG5184   197 GLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG-VVAIAA--GGSHTCALKSDGTVW 271

                  ....
gi 1907098250 173 MWGQ 176
Cdd:COG5184   272 CWGD 275

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250  13 VFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNkvVMNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVA 92
Cdd:COG5184   119 VWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG--VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVG 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250  93 ALQGirVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDrIIEIAAchSAHTSAAKTQGGHVY 172
Cdd:COG5184   197 GLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG-VVAIAA--GGSHTCALKSDGTVW 271

                  ....
gi 1907098250 173 MWGQ 176
Cdd:COG5184   272 CWGD 275

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907098250  235 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLED----SEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEEAVGL 303
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSdfkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEEL 73

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250  13 VFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNkvVMNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVA 92
Cdd:COG5184   119 VWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG--VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVG 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250  93 ALQGirVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDrIIEIAAchSAHTSAAKTQGGHVY 172
Cdd:COG5184   197 GLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG-VVAIAA--GGSHTCALKSDGTVW 271

                  ....
gi 1907098250 173 MWGQ 176
Cdd:COG5184   272 CWGD 275

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250  13 VFAWGYNNSGQVGSGSTANQPIPRRVTGcLQNkvVMNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVA 92
Cdd:COG5184    19 VWCWGDNSYGQLGDGTTTDRSTPVRVPG-LSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVP 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250  93 ALQGIRvqRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAAchSAHTSAAKTQGGHVY 172
Cdd:COG5184    96 GLTGVV--AVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSGVVAIAA--GGYHTCALKSDGTVW 171

                  ...
gi 1907098250 173 MWG 175
Cdd:COG5184   172 CWG 174

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250  13 VFAWGYNNSGQVGSGSTANQPIPRRVTGclQNKVVMnIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVA 92
Cdd:COG5184    69 VWCWGNNSYGQLGDGTTTDRTTPVKVPG--LTGVVA-VAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVD 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250  93 AlQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPvVVEKDRIIEIAAchSAHTSAAKTQGGHVY 172
Cdd:COG5184   146 A-GLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQ-VGGLSGVVAVAA--GGDHSCALKSDGTVW 221

                  ...
gi 1907098250 173 MWG 175
Cdd:COG5184   222 CWG 224

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250  12 QVFAWGYNNSGQVGSGSTANQPIPRRVTGcLQNkvVMNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRV 91
Cdd:COG5184   219 TVWCWGSNSSGQLGDGTTTDRATPVQVAG-LTG--VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKV 295

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907098250  92 AALQGirVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPT 141
Cdd:COG5184   296 PGLSG--VVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTPV 343

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250 221 AESLKREFDNPDTADLKFLV--DGKYIYAHKVLLKIRCEHFRSSL-----EDSEDDIVEMSEFSYPVFRAFLEYLYTDNI 293
Cdd:cd18294     2 AADMKSLINNPEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFltgpqKESTQSPLVLSDIEPEVFRAVLEFIYTNCV 81

                          90
                  ....*....|
gi 1907098250 294 SLSPEEAVGL 303
Cdd:cd18294    82 TLSNHTVIEV 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907098250 234 ADLKFLVDGKYIYAHKVLLKIRCEHFR----SSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEEAVGL 303
Cdd:cd18186     2 CDVTLVVGGREFPAHRAVLAARSPYFRamfsSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEEL 75

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250 228 FDNPDTADLKFLVDGKYIYAHKVLLKIRCEH----FRSSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPE-EAVG 302
Cdd:cd18300     4 LNKGLFSDVTFIVEDGTIPAHKALLVARCDVmaamFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEDgDCVG 83

                  .
gi 1907098250 303 L 303
Cdd:cd18300    84 L 84

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907098250  235 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLED----SEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEEAVGL 303
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSdfkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEEL 73

Regulator of chromosome condensation (RCC1) repeat;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1907098250  12 QVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMnIACGQMCSMAV 60
Cdd:pfam00415   3 RVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQ-VACGGDHTVAL 50

Regulator of chromosome condensation (RCC1) repeat;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1907098250 115 EGQIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSA 163
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVA 49

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907098250 229 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHF------RSSLEDSEDDIVEMSEFSYPVFRAFLEYLY 289
Cdd:cd18350    20 NNKEMSDVTFLVEGKLFYAHKVLLVTASNRFkslltnKSEQESQGSKTIEISDIKYHIFQMLMQYLY 86

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250 229 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLED---------SEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEE 299
Cdd:cd18296    13 QELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDhfaeseennGSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPEN 92

                  ..
gi 1907098250 300 AV 301
Cdd:cd18296    93 AY 94

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250 229 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLE----DSEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEEAVGLR 304
Cdd:cd18352     9 NNATLSDVTFLVEGRRFYAHRIALLASSDAFRAMFDggyrEKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLL 88

                  ....*..
gi 1907098250 305 RVLLQVL 311
Cdd:cd18352    89 RAADQYL 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907098250 228 FDNPDTADLKFLVDGKYIYAHKVLLKIRCEhFRSSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEE 299
Cdd:cd18303    13 FDKELYSDITIKLADKSIPAHKFVLAARSE-KWSNENLASTNELDLSDISYEVVLALLRWLYTDELDLTLDD 83

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250 228 FDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSL-----EDSEDDIVeMSEFSYPVFRAFLEYLYTDNISLSPEEAVG 302
Cdd:cd18314     1 YNDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLtgsmiESNLKEVT-LEDVEPEIFETVLKYMYTGQVTLSEENVLD 79

                  ....
gi 1907098250 303 LRRV 306
Cdd:cd18314    80 LLML 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907098250 237 KFLVDGKYIYAHKVLLKIRCEHFR----SSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEEAVGL 303
Cdd:cd01165     2 VLVVEGEKFHVNKELLAQSSEYFRalfrGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLEL 72

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907098250 224 LKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCE----HFRSSLEDSEDDIVEMSEFSYPVFRAFLEYLYTD 291
Cdd:cd18360     1 LGLFFNSPLLADVVFKIQGTTVPAHRAVLVARCEvmaaMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTD 72

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907098250 228 FDNPDTADLKFLVDGKY-IYAHKVLLKIRCEHFRSSLedSEDDIVEMSE-FSYPVFRAFLEYLYT 290
Cdd:cd18299     7 LHSPSCADVVFILQGGVrIFAHRIVLAAASSVFADLF--LMMTVVTLDSdITPEAFRRVLEFLYT 69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907098250 229 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSL------EDSEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPE 298
Cdd:cd18245    10 EEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLnynppkDDGSTYKIELEGISVEVMEEILDYIYTGQIKLSED 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250 220 VAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRC----EHFRSSLEDSEDDIVEMSEFSYPVFRAFLEYLYT----- 290
Cdd:cd18343     8 LAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSpvfnAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTgkapn 87

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1907098250 291 -----DNIsLSPEEAVGLRRvlLQVLHQPSDCSNTNV 322
Cdd:cd18343    88 ldkmaDNL-LAAADKYALER--LKVMCEEALCNNLSV 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907098250 235 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDsedDIVEMSEFSYPVFRAFLEYLYTDNISLSPEEAV 301
Cdd:cd18275     6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLSR---DILKVKGLSYATLRLLVDYVYSGRMAVSKDNVV 69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250 220 VAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRS----SLEDSEDDIVEMSEFSYPVFRAFLEYLYT----- 290
Cdd:cd18279     5 LAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAmfehEMEESKKNRVEINDVDPEVFKEMMRFIYTgkapn 84

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1907098250 291 -----DNIsLSPEEAVGLRRvlLQVLHQPSDCSNTNV 322
Cdd:cd18279    85 ldkmaDDL-LAAADKYALER--LKVMCEDALCSNLSV 118

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250 217 HLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCE----HFRSSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDN 292
Cdd:cd18358     4 HVRKANRIKECLSKGTFSDVTFKLDDGTINAHKPLLICSCEwmaaMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQ 83

                          90
                  ....*....|....*
gi 1907098250 293 IS----LSPEEAVGL 303
Cdd:cd18358    84 LSptadLDPLELIAL 98

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907098250 234 ADLKFLVDGKYIYAHKVLLKIRCEHFRSSLED---SEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEE 299
Cdd:cd18315     2 VDVTLACEGGSLKAHKLVLAAASPYFAALLKEtppDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQ 70

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250 234 ADLKFLVDGKYIYAHKVLLKIRCEHF-------RSSLEDseDDIVEMSEFSYPVFRAFLEYLYTDNISLS-PEEAVGLRR 305
Cdd:cd18285    16 TDVTFYVGSTLFKAHKAILLARVPEFfshiigkLSSLED--QEPINIENLEASEFKTFLRQVYTSDKNIKmLEEEILKGK 93

                          90
                  ....*....|.
gi 1907098250 306 VLLQVLHQPSD 316
Cdd:cd18285    94 VLDQKVDKEND 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250 219 TVAESLKREFDNPDTADLKFLVdGK-----YIYAHKVLLKIRC----EHFRSSLEDSEDDIvEMSEFSYPVFRAFLEYLY 289
Cdd:cd18281     8 TVKERFAFLFNNETLSDVHFIV-GKgdneqRIPAHKFVLSIGSavfdAMFNGGMATTSAEI-ELPDVEPAAFLALLRFLY 85

                  ....*....
gi 1907098250 290 TDNISLSPE 298
Cdd:cd18281    86 SDEVQIGPE 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907098250 234 ADLKFLVDGKYIYAHKVLLKIRCEHFRS----SLEDSEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEE 299
Cdd:cd18272    33 ADVTISVEGKEFQLHRLVLSAQSCFFRSmftsNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEE 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907098250 247 AHKVLLKIRCEHFRSSLEDSEDDIV--EMSEFSYPVFRAFLEYLYTDNISLSPEEAVGLRRV 306
Cdd:cd18217    32 AHRNVLAAFSEYFGAQYKDTEDNIVflDQSQVSADGFQKLLEFIYTGNLNLDSWNVAEIHQA 93

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907098250 234 ADLKFLVDGKYIYAHKVLLKIRCE----HFRSSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPE 298
Cdd:cd18359    21 SDVTFMLDDGTISAHKPLLISSCDwmaaMFGGPFVESSTTEVVFPYTSRSSMRAVLEYLYTGQFSSSPD 89