V-type proton ATPase subunit S1-like protein isoform X3 [Mus musculus]
V-type proton ATPase subunit S1( domain architecture ID 10530743)
V-type proton ATPase subunit S1 is an accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles
List of domain hits
Name | Accession | Description | Interval | E-value | |||
VAS1_LD | pfam05827 | V-type proton ATPase subunit S1, luminal domain; This entry represents the luminal domain (LD) ... |
20-121 | 1.03e-20 | |||
V-type proton ATPase subunit S1, luminal domain; This entry represents the luminal domain (LD) found in eukaryotic V-type proton ATPase subunit S1 involved in V-ATPase V0 assembly, including Ac45 subunit (ATP6AP1). This domain folds as a globular beta-prism structure which is structurally similar to LAMP1-3, thus, the LD domain of Ac45 is an evolutionarily conserved member of the LAMP family. Ac45 is an ER membrane protein that guides the V-type ATPase into specialized subcellular compartments and is critical for Vo complex assembly as it connects to multiple Vo subunits and phospholipids in the c-ring. Missense mutations in the X-linked ATP6AP1 gene cause immunodeficiency in males that leads to recurrent bacterial infection, hepatopathy, cognitive impairment, and abnormal protein glycosylation. : Pssm-ID: 461752 Cd Length: 144 Bit Score: 84.07 E-value: 1.03e-20
|
|||||||
Ac45-VOA1_TM | pfam20520 | V0 complex accessory subunit Ac45/VOA1 transmembrane domain; This entry represents the ... |
138-173 | 2.54e-07 | |||
V0 complex accessory subunit Ac45/VOA1 transmembrane domain; This entry represents the transmembrane domain from ER/Golgi membrane proteins including V0 complex accessory subunit Ac45 (ATP6AP1, also known as V-type proton ATPase subunit S1) from animals and the yeast homolog V0 assembly protein 1 (VOA1) which are essential for V0 ATPase assembly, stability and function. In humans, mutations of ATP6AP1 cause immunodeficiency with hypogammaglobulinemia, hepatopathy and neurocognitive abnormalities. This entry also includes ER membrane BIG1 proteins from yeast, involved in cell wall biogenesis. : Pssm-ID: 466669 Cd Length: 39 Bit Score: 45.44 E-value: 2.54e-07
|
|||||||
Name | Accession | Description | Interval | E-value | |||
VAS1_LD | pfam05827 | V-type proton ATPase subunit S1, luminal domain; This entry represents the luminal domain (LD) ... |
20-121 | 1.03e-20 | |||
V-type proton ATPase subunit S1, luminal domain; This entry represents the luminal domain (LD) found in eukaryotic V-type proton ATPase subunit S1 involved in V-ATPase V0 assembly, including Ac45 subunit (ATP6AP1). This domain folds as a globular beta-prism structure which is structurally similar to LAMP1-3, thus, the LD domain of Ac45 is an evolutionarily conserved member of the LAMP family. Ac45 is an ER membrane protein that guides the V-type ATPase into specialized subcellular compartments and is critical for Vo complex assembly as it connects to multiple Vo subunits and phospholipids in the c-ring. Missense mutations in the X-linked ATP6AP1 gene cause immunodeficiency in males that leads to recurrent bacterial infection, hepatopathy, cognitive impairment, and abnormal protein glycosylation. Pssm-ID: 461752 Cd Length: 144 Bit Score: 84.07 E-value: 1.03e-20
|
|||||||
Ac45-VOA1_TM | pfam20520 | V0 complex accessory subunit Ac45/VOA1 transmembrane domain; This entry represents the ... |
138-173 | 2.54e-07 | |||
V0 complex accessory subunit Ac45/VOA1 transmembrane domain; This entry represents the transmembrane domain from ER/Golgi membrane proteins including V0 complex accessory subunit Ac45 (ATP6AP1, also known as V-type proton ATPase subunit S1) from animals and the yeast homolog V0 assembly protein 1 (VOA1) which are essential for V0 ATPase assembly, stability and function. In humans, mutations of ATP6AP1 cause immunodeficiency with hypogammaglobulinemia, hepatopathy and neurocognitive abnormalities. This entry also includes ER membrane BIG1 proteins from yeast, involved in cell wall biogenesis. Pssm-ID: 466669 Cd Length: 39 Bit Score: 45.44 E-value: 2.54e-07
|
|||||||
Name | Accession | Description | Interval | E-value | |||
VAS1_LD | pfam05827 | V-type proton ATPase subunit S1, luminal domain; This entry represents the luminal domain (LD) ... |
20-121 | 1.03e-20 | |||
V-type proton ATPase subunit S1, luminal domain; This entry represents the luminal domain (LD) found in eukaryotic V-type proton ATPase subunit S1 involved in V-ATPase V0 assembly, including Ac45 subunit (ATP6AP1). This domain folds as a globular beta-prism structure which is structurally similar to LAMP1-3, thus, the LD domain of Ac45 is an evolutionarily conserved member of the LAMP family. Ac45 is an ER membrane protein that guides the V-type ATPase into specialized subcellular compartments and is critical for Vo complex assembly as it connects to multiple Vo subunits and phospholipids in the c-ring. Missense mutations in the X-linked ATP6AP1 gene cause immunodeficiency in males that leads to recurrent bacterial infection, hepatopathy, cognitive impairment, and abnormal protein glycosylation. Pssm-ID: 461752 Cd Length: 144 Bit Score: 84.07 E-value: 1.03e-20
|
|||||||
Ac45-VOA1_TM | pfam20520 | V0 complex accessory subunit Ac45/VOA1 transmembrane domain; This entry represents the ... |
138-173 | 2.54e-07 | |||
V0 complex accessory subunit Ac45/VOA1 transmembrane domain; This entry represents the transmembrane domain from ER/Golgi membrane proteins including V0 complex accessory subunit Ac45 (ATP6AP1, also known as V-type proton ATPase subunit S1) from animals and the yeast homolog V0 assembly protein 1 (VOA1) which are essential for V0 ATPase assembly, stability and function. In humans, mutations of ATP6AP1 cause immunodeficiency with hypogammaglobulinemia, hepatopathy and neurocognitive abnormalities. This entry also includes ER membrane BIG1 proteins from yeast, involved in cell wall biogenesis. Pssm-ID: 466669 Cd Length: 39 Bit Score: 45.44 E-value: 2.54e-07
|
|||||||
Blast search parameters | ||||
|