|
Name |
Accession |
Description |
Interval |
E-value |
| KRAB |
smart00349 |
krueppel associated box; |
2-60 |
4.26e-30 |
|
krueppel associated box;
Pssm-ID: 214630 [Multi-domain] Cd Length: 61 Bit Score: 113.07 E-value: 4.26e-30
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1907093310 2 LSFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSNLVFLGLASCKPHLITCLEQIQEP 60
Cdd:smart00349 1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
|
|
| KRAB |
pfam01352 |
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ... |
1-42 |
3.48e-22 |
|
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.
Pssm-ID: 460171 Cd Length: 42 Bit Score: 89.84 E-value: 3.48e-22
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1907093310 1 MLSFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSNLVFLG 42
Cdd:pfam01352 1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
|
|
| KRAB_A-box |
cd07765 |
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ... |
2-41 |
6.60e-19 |
|
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.
Pssm-ID: 143639 Cd Length: 40 Bit Score: 80.67 E-value: 6.60e-19
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1907093310 2 LSFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSNLVFL 41
Cdd:cd07765 1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
216-657 |
9.73e-13 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 71.65 E-value: 9.73e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 216 KPYKCEICDKAFHYPSILSKHKRIHTGEKPYKC--EECGKAFHISSFLSKHKIIHRGEKPYKCEV-CGKAFHYPSRLSNH 292
Cdd:COG5048 32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 293 KKIHSGEKPFKCEVCGKAFRILSLLSKHKIIHTEENPYKCEVC-GKAFDYPSRLSTHAKMHTGEKpykcevCQKAFRSLS 371
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 372 SLSKHKRIHTEDNYYNNELCGKAFIYPSRLSKHKRiCAGEKPYKCEVCGKAFHVSSLLSKHRTIHTGEKLYKCEVCGKAF 451
Cdd:COG5048 186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 452 YYPSRLSNHKKIHTGE-------KPFQCEVCGKAFCFPSSLSKHKR--IHTGE--KPYKCKE--CGKAFRSLSSLSKHKR 518
Cdd:COG5048 265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 519 IHTGEKPYKCEECgkafhypSLLSKHKIIHTEEKPykcdvcgqAFHVPSKLSHHKIIHTGEKPYKCEVCGKAFCIPLLLS 598
Cdd:COG5048 345 LHTSISPAKEKLL-------NSSSKFSPLLNNEPP--------QSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHII 409
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 1907093310 599 KHKRVHTGENPYNsqVCSKAFVYPSKLSKHKKVRTKEKPYKCEVCGKAFRFPSLLLIHK 657
Cdd:COG5048 410 THLSFRPYNCKNP--PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
496-938 |
2.88e-10 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 63.56 E-value: 2.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 496 KPYKCKECGKAFRSLSSLSKHKRIHTGEKPYKC--EECGKAFHYPSLLSKHKIIHTEEKPYKCDvcGQAFHVPSKLSHHK 573
Cdd:COG5048 32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 574 IIHtgekpykcevCGKAFCIPLLLSKHKRVHTGENPYNSQVCSKAFVYPSKLSKHKKVRTKEKPYKC--------EVCGK 645
Cdd:COG5048 110 LSS----------SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKD 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 646 AFRFPSLLLIHKGMHTGEKPYKCEDCGKAFHYPSLLSKHKRihtgekpyqcevcgkdFHVSSSLSKHRIIHTGEKPYKCE 725
Cdd:COG5048 180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL----------------ENSSSSLPLTTNSQLSPKSLLSQ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 726 icgktfRFSSSLSKHKRNHTGKKPYKC---EECGKAFHFPSILAKHKISHTgekPYNCDLCGKAFHYASLLSKHK--MIH 800
Cdd:COG5048 244 ------SPSSLSSSDSSSSASESPRSSlptASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNH 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 801 TGE--KPHKCDI--CGKAFHYPSKLSNHKKIHTGEKPYKC--EVCGNVF------CFASSLSKHKRIHTG---ENPYKCE 865
Cdd:COG5048 315 SGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDkksETLSNSC 394
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907093310 866 VCGKAFYYPSLLSKHKIIHTGEKPYKCDLCGKAFHYPSLLSKHKVIHTGKKPYKCEVCGKaFHYPSRLSKHKK 938
Cdd:COG5048 395 IRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
|
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
484-509 |
8.63e-04 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 37.35 E-value: 8.63e-04
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
130-199 |
3.10e-03 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 41.24 E-value: 3.10e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907093310 130 GEKPYKCEV--CGKAFCIPLLLsKHKRVHTGENlykcevcGKAFQHPSRLSrHKKIHSEEKPYKCEVCGKAF 199
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGL-KYHMLHGHQN-------QKLHENPSPEK-MNIFSAKDKPYRCEVCDKRY 408
|
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
736-759 |
3.88e-03 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 35.81 E-value: 3.88e-03
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| KRAB |
smart00349 |
krueppel associated box; |
2-60 |
4.26e-30 |
|
krueppel associated box;
Pssm-ID: 214630 [Multi-domain] Cd Length: 61 Bit Score: 113.07 E-value: 4.26e-30
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1907093310 2 LSFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSNLVFLGLASCKPHLITCLEQIQEP 60
Cdd:smart00349 1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
|
|
| KRAB |
pfam01352 |
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ... |
1-42 |
3.48e-22 |
|
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.
Pssm-ID: 460171 Cd Length: 42 Bit Score: 89.84 E-value: 3.48e-22
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1907093310 1 MLSFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSNLVFLG 42
Cdd:pfam01352 1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
|
|
| KRAB_A-box |
cd07765 |
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ... |
2-41 |
6.60e-19 |
|
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.
Pssm-ID: 143639 Cd Length: 40 Bit Score: 80.67 E-value: 6.60e-19
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1907093310 2 LSFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSNLVFL 41
Cdd:cd07765 1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
216-657 |
9.73e-13 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 71.65 E-value: 9.73e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 216 KPYKCEICDKAFHYPSILSKHKRIHTGEKPYKC--EECGKAFHISSFLSKHKIIHRGEKPYKCEV-CGKAFHYPSRLSNH 292
Cdd:COG5048 32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 293 KKIHSGEKPFKCEVCGKAFRILSLLSKHKIIHTEENPYKCEVC-GKAFDYPSRLSTHAKMHTGEKpykcevCQKAFRSLS 371
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 372 SLSKHKRIHTEDNYYNNELCGKAFIYPSRLSKHKRiCAGEKPYKCEVCGKAFHVSSLLSKHRTIHTGEKLYKCEVCGKAF 451
Cdd:COG5048 186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 452 YYPSRLSNHKKIHTGE-------KPFQCEVCGKAFCFPSSLSKHKR--IHTGE--KPYKCKE--CGKAFRSLSSLSKHKR 518
Cdd:COG5048 265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 519 IHTGEKPYKCEECgkafhypSLLSKHKIIHTEEKPykcdvcgqAFHVPSKLSHHKIIHTGEKPYKCEVCGKAFCIPLLLS 598
Cdd:COG5048 345 LHTSISPAKEKLL-------NSSSKFSPLLNNEPP--------QSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHII 409
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 1907093310 599 KHKRVHTGENPYNsqVCSKAFVYPSKLSKHKKVRTKEKPYKCEVCGKAFRFPSLLLIHK 657
Cdd:COG5048 410 THLSFRPYNCKNP--PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
440-843 |
1.22e-11 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 68.18 E-value: 1.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 440 KLYKCEVCGKAFYYPSRLSNHKKIHTGEKPFQCEV--CGKAFCFPSSLSKHKRIHTGEKPYKC-KECGKAFRSLSSLSKH 516
Cdd:COG5048 32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 517 KRIHTGEKPYKCEECGKAFHYPSLLSKHKIIHTEEKPYKCDVC-GQAFHVPSKLSHHKIIHTGEKPykcevcgKAFCIPL 595
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 596 LLSKHKRVHTGENPYNSQVCSKAFVYPSKLSKHKKVRTKEKPYKCEVCGKAFRFPSLLLIH-KGMHTGEKPYKCEDCGKA 674
Cdd:COG5048 185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSS 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 675 F---------HYPSLLSKHKRIHTgekPYQCEVCGKDFHVSSSLSKHR--IIHTGE--KPYKC--EICGKTFRFSSSLSK 739
Cdd:COG5048 265 LptassqsssPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKR 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 740 HKRNHTGKKPYKC--EECGKAFHFPSI------LAKHKISHTgEKPYNCDL--CGKAFHYASLLSKHKMIHTGEKPH--K 807
Cdd:COG5048 342 HILLHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKN-DKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYncK 420
|
410 420 430
....*....|....*....|....*....|....*.
gi 1907093310 808 CDICGKAFHYPSKLSNHKKIHTGEKPYKCEVCGNVF 843
Cdd:COG5048 421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
496-938 |
2.88e-10 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 63.56 E-value: 2.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 496 KPYKCKECGKAFRSLSSLSKHKRIHTGEKPYKC--EECGKAFHYPSLLSKHKIIHTEEKPYKCDvcGQAFHVPSKLSHHK 573
Cdd:COG5048 32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 574 IIHtgekpykcevCGKAFCIPLLLSKHKRVHTGENPYNSQVCSKAFVYPSKLSKHKKVRTKEKPYKC--------EVCGK 645
Cdd:COG5048 110 LSS----------SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKD 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 646 AFRFPSLLLIHKGMHTGEKPYKCEDCGKAFHYPSLLSKHKRihtgekpyqcevcgkdFHVSSSLSKHRIIHTGEKPYKCE 725
Cdd:COG5048 180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL----------------ENSSSSLPLTTNSQLSPKSLLSQ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 726 icgktfRFSSSLSKHKRNHTGKKPYKC---EECGKAFHFPSILAKHKISHTgekPYNCDLCGKAFHYASLLSKHK--MIH 800
Cdd:COG5048 244 ------SPSSLSSSDSSSSASESPRSSlptASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNH 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 801 TGE--KPHKCDI--CGKAFHYPSKLSNHKKIHTGEKPYKC--EVCGNVF------CFASSLSKHKRIHTG---ENPYKCE 865
Cdd:COG5048 315 SGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDkksETLSNSC 394
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907093310 866 VCGKAFYYPSLLSKHKIIHTGEKPYKCDLCGKAFHYPSLLSKHKVIHTGKKPYKCEVCGKaFHYPSRLSKHKK 938
Cdd:COG5048 395 IRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
103-546 |
1.93e-09 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 61.25 E-value: 1.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 103 MNPNKCEECARSFHSPSLSSEENRIHTGEKPYKCEV--CGKAFCIPLLLSKHKRVHTgenlykcevcgkafQHPSRLSRH 180
Cdd:COG5048 31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHH--------------NNPSDLNSK 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 181 KKIHSEEKPYKCEVCGKAFHFPSLLLVHKRVHTGEKPYK-------CEICDKAFHYPSILSKHKRIHTGEKPYKCE---E 250
Cdd:COG5048 97 SLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPqlpdllsISNLRNNPLPGNNSSSVNTPQSNSLHPPLPansL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 251 CGKAFHISSFLSKHKIIHRGEKPYKCEVCGKAFHYPSRLSNHKKIHSgEKPFKCEVCGKAFRILSLLSKH-KIIHTEENP 329
Cdd:COG5048 177 SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSS 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 330 YKCEVCGKAFDYPSRLSTHAKMHTGEK------PYKCEVCQKAFRSLSSLSKHKR--IHTEDNYY----NNELCGKAFIY 397
Cdd:COG5048 256 SASESPRSSLPTASSQSSSPNESDSSSekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKpfscPYSLCGKLFSR 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 398 PSRLSKHKRICAGEKPYKC--EVCGKAFHVSSLLSKHRTIHtgeklykcevcgkafyyPSRLSNHKKIHTGEKPFQCEVC 475
Cdd:COG5048 336 NDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ-----------------QYKDLKNDKKSETLSNSCIRNF 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907093310 476 GKAFCFPSSLSKHKRihTGEKPYKCKECGKAFRSLSSLSKHKRIHTGEKPYKCEECGKaFHYPSLLSKHKI 546
Cdd:COG5048 399 KRDSNLSLHIITHLS--FRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
607-920 |
3.72e-08 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 57.01 E-value: 3.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 607 ENPYNSQVCSKAFVYPSKlSKHKKVRTKEKPYKCEVCGKAFRFPSLLLIHKGMHTGEKPYKCED--CGKAFHYPSLLSKH 684
Cdd:COG5048 4 TSSQSSSSNNSVLSSTPK-STLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRH 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 685 KRIHTGEKPYQCEVCGKDFHVSSSLSKHRIIHT----GEKPYKCEICGKTFRFSSSLSKHKRNHTGKKPYKC-------- 752
Cdd:COG5048 83 LRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSnsndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntp 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 753 ------------EECGKAFHFPSILAKHKISHTGEKPYNCDLCGKAFHYASLLSKHKMIHTgEKPHKCDICGKAFHYPSK 820
Cdd:COG5048 163 qsnslhpplpanSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 821 LSNH-KKIHTGEKPYKCEVCGNVFCFASS---------LSKHKRIHTgenPYKCEVCGKAFYYPSLLSKHK--IIHTGE- 887
Cdd:COG5048 242 SQSPsSLSSSDSSSSASESPRSSLPTASSqssspnesdSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEs 318
|
330 340 350
....*....|....*....|....*....|....*.
gi 1907093310 888 -KPYKCD--LCGKAFHYPSLLSKHKVIHTGKKPYKC 920
Cdd:COG5048 319 lKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKE 354
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
369-826 |
1.29e-07 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 55.09 E-value: 1.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 369 SLSSLSKHKRIHTEDNYYNNELCGKAFIYPSRLSKHKRICAGEKPYKCEV--CGKAFHVSSLLSKHRTIHTGEKLYKCEV 446
Cdd:COG5048 17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSK 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 447 -CGKAFYYPSRLSNHKKIHTGEKPFQCEVCGKAFCFPSSLSKHKRIHTGEKPYKCKEC-GKAFRSLSSLSKHKRIHTGEK 524
Cdd:COG5048 97 sLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 525 pykceeCGKAFHYPSLLSKHKIIHTEEKPYKCdvcgQAFHVPSKLSHHKIIHTGEKPYKCEVCGKAFCIPLLLSKHKRvH 604
Cdd:COG5048 177 ------SKDPSSNLSLLISSNVSTSIPSSSEN----SPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQS-P 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 605 TGENPYNSQVCSKAFVYPSKLSKHKKVRTKekpykcevcgkafrFPSLLLIHKGMHTgekPYKCEDCGKAFHYPSLLSKH 684
Cdd:COG5048 246 SSLSSSDSSSSASESPRSSLPTASSQSSSP--------------NESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRH 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 685 KR--IHTGE--KPYQC--EVCGKDFHVSSSLSKHRIIHTGEKPYKC--EICGKTFRFSS------SLSKHKRNHTGKKPY 750
Cdd:COG5048 309 LRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppqSLQQYKDLKNDKKSE 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 751 kCEECGKAFHFP--SILAKHKISHTGEKPYNCD--LCGKAFHYASLLSKHKMIHTGEKPHKCDICGKaFHYPSKLSNHKK 826
Cdd:COG5048 389 -TLSNSCIRNFKrdSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
340-434 |
1.57e-06 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 51.64 E-value: 1.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 340 DYPSRLsthaKMHTGEKPYKCEV--CQKAFRSLSSLsKHKRIHTEDNYYNNElcgkafiYPSRlSKHKRICAGEKPYKCE 417
Cdd:COG5189 336 DTPSRM----LKVKDGKPYKCPVegCNKKYKNQNGL-KYHMLHGHQNQKLHE-------NPSP-EKMNIFSAKDKPYRCE 402
|
90
....*....|....*..
gi 1907093310 418 VCGKAFHVSSLLSKHRT 434
Cdd:COG5189 403 VCDKRYKNLNGLKYHRK 419
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
214-297 |
2.15e-05 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 48.18 E-value: 2.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 214 GEKPYKCEI--CDKAFHYPSILSKHKrihtgekpyKCEECGKAFHISSFLSKHKIIHRGEKPYKCEVCGKAFHYPSRLSN 291
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416
|
....*.
gi 1907093310 292 HKKiHS 297
Cdd:COG5189 417 HRK-HS 421
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
662-745 |
8.67e-05 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 46.25 E-value: 8.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 662 GEKPYKCE--DCGKAFHYPSLLsKHKRIHTGekpyqcevCGKDFHVSSSLSKHRIIHTGEKPYKCEICGKTFRFSSSLSK 739
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416
|
....*.
gi 1907093310 740 HKRNHT 745
Cdd:COG5189 417 HRKHSH 422
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
578-661 |
2.27e-04 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 44.71 E-value: 2.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 578 GEKPYKCEV--CGKAFCIPLLLsKHKRVHTGENPYNSQVCSKafvypsklSKHKKVRTKEKPYKCEVCGKAFRFPSLLLI 655
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGL-KYHMLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416
|
....*.
gi 1907093310 656 HKGMHT 661
Cdd:COG5189 417 HRKHSH 422
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
270-353 |
2.72e-04 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 44.32 E-value: 2.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 270 GEKPYKCEV--CGKAFHYPSRLSNHKKiHSGEKPFKCEVCGKafrilsllSKHKIIHTEENPYKCEVCGKAFDYPSRLST 347
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416
|
....*.
gi 1907093310 348 HAKMHT 353
Cdd:COG5189 417 HRKHSH 422
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
494-573 |
4.48e-04 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 43.94 E-value: 4.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 494 GEKPYKCK--ECGKAFRSLSSLSKHKrihtgekpyKCEECGKAFHYPSLLSKHKIIHTEEKPYKCDVCGQAFHVPSKLSH 571
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416
|
..
gi 1907093310 572 HK 573
Cdd:COG5189 417 HR 418
|
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
484-509 |
8.63e-04 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 37.35 E-value: 8.63e-04
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
718-797 |
9.92e-04 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 42.78 E-value: 9.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 718 GEKPYKCEI--CGKTFRFSSSLSKHKRNHtgkkpykceECGKAFHFPSILAKHKISHTGEKPYNCDLCGKAFHYASLLSK 795
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYHMLHG---------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416
|
..
gi 1907093310 796 HK 797
Cdd:COG5189 417 HR 418
|
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
512-535 |
1.62e-03 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 36.58 E-value: 1.62e-03
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
233-255 |
2.05e-03 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 36.58 E-value: 2.05e-03
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
522-591 |
3.07e-03 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 41.24 E-value: 3.07e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907093310 522 GEKPYKCE--ECGKAFHYPSLLSKHKIiHTEekpykcdvCGQAFHVPSKLSHHKIIHTGEKPYKCEVCGKAF 591
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRY 408
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
130-199 |
3.10e-03 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 41.24 E-value: 3.10e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907093310 130 GEKPYKCEV--CGKAFCIPLLLsKHKRVHTGENlykcevcGKAFQHPSRLSrHKKIHSEEKPYKCEVCGKAF 199
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGL-KYHMLHGHQN-------QKLHENPSPEK-MNIFSAKDKPYRCEVCDKRY 408
|
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
736-759 |
3.88e-03 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 35.81 E-value: 3.88e-03
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
858-938 |
3.95e-03 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 40.86 E-value: 3.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 858 GENPYKCEV--CGKAFYYPSLLSKHKiihtgekpyKCDLCGKAFHYPSLLSKHKVIHTGKKPYKCEVCGKAFHYPSRLSK 935
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416
|
...
gi 1907093310 936 HKK 938
Cdd:COG5189 417 HRK 419
|
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
681-703 |
6.21e-03 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 35.04 E-value: 6.21e-03
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
848-873 |
7.64e-03 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 34.65 E-value: 7.64e-03
|
| |
