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Conserved domains on  [gi|1907134107|ref|XP_036012683|]
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uncharacterized protein LOC100043915 isoform X6 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
42-454 4.33e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 4.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107  42 PSEFIQCGKAFAYESGRQRHQIKHNGEKHHDCNQCGKD--FRTWNVLQIHKRTHTGEKPYDC-KQCGKVFARSCHLQIHN 118
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107 119 RTHAGEKQYECNQCGKAFKRRINLQIHKRTHTGEKPYECNQC-GKAFASSGELQKHKRTHTGEKPyeckqcgKAFSQSSH 197
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107 198 LRIHKRTHTGEKPYECNQCGKAFARSGDLQKHKRTHTGEKPYECKQCGKAFAHS------SHLHKHERTHTGDKPYECKQ 271
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107 272 CGKAFAVIYTLQMHKRTHTG-DKPYECKQCGKAFAVIYTLQMHKRT--HTGE--KPYKC--KQCGKAFARSCHLRIHKRT 344
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107 345 HTGEKPYEC--NQCGKAF-----AESSTLQIHNRTHTGEKPYEC--NQCGKAFITRRVLQIHKRTHTGEKPYECN--QCG 413
Cdd:COG5048   346 HTSISPAKEklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1907134107 414 KAFARSCDLQKHKRTHTGEKPYECNHCGKAFAQSSSLRIHK 454
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
42-454 4.33e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 4.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107  42 PSEFIQCGKAFAYESGRQRHQIKHNGEKHHDCNQCGKD--FRTWNVLQIHKRTHTGEKPYDC-KQCGKVFARSCHLQIHN 118
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107 119 RTHAGEKQYECNQCGKAFKRRINLQIHKRTHTGEKPYECNQC-GKAFASSGELQKHKRTHTGEKPyeckqcgKAFSQSSH 197
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107 198 LRIHKRTHTGEKPYECNQCGKAFARSGDLQKHKRTHTGEKPYECKQCGKAFAHS------SHLHKHERTHTGDKPYECKQ 271
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107 272 CGKAFAVIYTLQMHKRTHTG-DKPYECKQCGKAFAVIYTLQMHKRT--HTGE--KPYKC--KQCGKAFARSCHLRIHKRT 344
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107 345 HTGEKPYEC--NQCGKAF-----AESSTLQIHNRTHTGEKPYEC--NQCGKAFITRRVLQIHKRTHTGEKPYECN--QCG 413
Cdd:COG5048   346 HTSISPAKEklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1907134107 414 KAFARSCDLQKHKRTHTGEKPYECNHCGKAFAQSSSLRIHK 454
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
169-194 5.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.06e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907134107 169 ELQKHKRTHTGEKPYECKQCGKAFSQ 194
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
42-454 4.33e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 4.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107  42 PSEFIQCGKAFAYESGRQRHQIKHNGEKHHDCNQCGKD--FRTWNVLQIHKRTHTGEKPYDC-KQCGKVFARSCHLQIHN 118
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107 119 RTHAGEKQYECNQCGKAFKRRINLQIHKRTHTGEKPYECNQC-GKAFASSGELQKHKRTHTGEKPyeckqcgKAFSQSSH 197
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107 198 LRIHKRTHTGEKPYECNQCGKAFARSGDLQKHKRTHTGEKPYECKQCGKAFAHS------SHLHKHERTHTGDKPYECKQ 271
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107 272 CGKAFAVIYTLQMHKRTHTG-DKPYECKQCGKAFAVIYTLQMHKRT--HTGE--KPYKC--KQCGKAFARSCHLRIHKRT 344
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107 345 HTGEKPYEC--NQCGKAF-----AESSTLQIHNRTHTGEKPYEC--NQCGKAFITRRVLQIHKRTHTGEKPYECN--QCG 413
Cdd:COG5048   346 HTSISPAKEklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1907134107 414 KAFARSCDLQKHKRTHTGEKPYECNHCGKAFAQSSSLRIHK 454
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-465 4.61e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 4.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107 166 SSGELQKHKRTHTGE----KPYECKQCGKAFSQSSHLRIHKRTHTGEKPYECNQ--CGKAFARSGDLQKHKRTHTGEKPY 239
Cdd:COG5048    13 NSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107 240 ECKQCGKAFAHSSHLHKHERTHTGD-KPYECKQCGKAFAVIYTLQMHKRTHTGDKPYECKQCGKAFAVIYT--------- 309
Cdd:COG5048    93 LNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplp 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107 310 -------------LQMHKRTHTGEKPYKCKQCGKAFARSCHLRIHKRTHTGEKPYECNQCGKAFAESSTLQIHNRT---- 372
Cdd:COG5048   173 anslskdpssnlsLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsssd 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107 373 --HTGEKPYECNQCGKAFITRRVLQIHKRTHTG-EKPYECNQCGKAFARSCDLQKHKRT--HTGE--KPYECNH--CGKA 443
Cdd:COG5048   253 ssSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKL 332

                         330       340
                  ....*....|....*....|..
gi 1907134107 444 FAQSSSLRIHKRTYTGERQYEC 465
Cdd:COG5048   333 FSRNDALKRHILLHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
97-257 2.94e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 2.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107  97 KPYDCKQCGKVFARSCHLQIHNRT--HAGE--KQYEC--NQCGKAFKRRINLQIHKRTHTGEKPYEC--NQCGKAF---- 164
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspll 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907134107 165 --ASSGELQKHKRTHTgEKPYEC--KQCGKAFSQSSHLRIHKRTHTGEKPYECN--QCGKAFARSGDLQKHKRTHTGEKP 238
Cdd:COG5048   368 nnEPPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAP 446

                         170       180
                  ....*....|....*....|.
gi 1907134107 239 YECKQCGK--AFAHSSHLHKH 257
Cdd:COG5048   447 LLCSILKSfrRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
169-194 5.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.06e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907134107 169 ELQKHKRTHTGEKPYECKQCGKAFSQ 194
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
310-334 5.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.42e-04
                          10        20
                  ....*....|....*....|....*
gi 1907134107 310 LQMHKRTHTGEKPYKCKQCGKAFAR 334
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
225-250 5.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.48e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907134107 225 DLQKHKRTHTGEKPYECKQCGKAFAH 250
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
421-446 8.69e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.69e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907134107 421 DLQKHKRTHTGEKPYECNHCGKAFAQ 446
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
141-166 1.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.05e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907134107 141 NLQIHKRTHTGEKPYECNQCGKAFAS 166
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
197-222 1.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.11e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907134107 197 HLRIHKRTHTGEKPYECNQCGKAFAR 222
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
337-361 2.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.00e-03
                          10        20
                  ....*....|....*....|....*
gi 1907134107 337 HLRIHKRTHTGEKPYECNQCGKAFA 361
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
282-305 2.41e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.41e-03
                          10        20
                  ....*....|....*....|....
gi 1907134107 282 LQMHKRTHTGDKPYECKQCGKAFA 305
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
394-418 2.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.48e-03
                          10        20
                  ....*....|....*....|....*
gi 1907134107 394 LQIHKRTHTGEKPYECNQCGKAFAR 418
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
405-466 5.98e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 5.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907134107 405 KPYECNQCGKAFARSCDLQKHKRTHTGEKPYECNHCGKAFAQS--SSLRIHKRTYTGERQYECN 466
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNS 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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