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Conserved domains on  [gi|1907079514|ref|XP_036012100|]
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serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X5 [Mus musculus]

Protein Classification

SMEK family protein( domain architecture ID 11459)

SMEK (Suppressor of Mek1) family protein similar to Dictyostelium discoideum SMEK that suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects

Gene Ontology:  GO:0030289|GO:0019888
PubMed:  16085932

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PP4R3 super family cl04762
Phosphatase 4 regulatory subunit 3; This entry represents the Serine/threonine-protein ...
 12-63 1.09e-20

Phosphatase 4 regulatory subunit 3; This entry represents the Serine/threonine-protein phosphatase 4 regulatory subunit 3 (also known as SMEK homolog) PP4R3, which forms a complex with the phosphatase 4 catalytic subunit (PP4c), localising it to the DNA damage repair machinery and regulates its activity. PP4c is involved in developmental progression, chemotaxis, expression of stress response genes and cell movement.


The actual alignment was detected with superfamily member pfam04802:

Pssm-ID: 461435  Cd Length: 191  Bit Score: 89.82  E-value: 1.09e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907079514  12 EDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTL 63
Cdd:pfam04802 140 EDEEFLKELFAILRDPETSDEKRRDGVLFLKEFCSIAKNLQPPSRSEFFKTL 191
 
Name Accession Description Interval E-value
PP4R3 pfam04802
Phosphatase 4 regulatory subunit 3; This entry represents the Serine/threonine-protein ...
 12-63 1.09e-20

Phosphatase 4 regulatory subunit 3; This entry represents the Serine/threonine-protein phosphatase 4 regulatory subunit 3 (also known as SMEK homolog) PP4R3, which forms a complex with the phosphatase 4 catalytic subunit (PP4c), localising it to the DNA damage repair machinery and regulates its activity. PP4c is involved in developmental progression, chemotaxis, expression of stress response genes and cell movement.


Pssm-ID: 461435  Cd Length: 191  Bit Score: 89.82  E-value: 1.09e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907079514  12 EDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTL 63
Cdd:pfam04802 140 EDEEFLKELFAILRDPETSDEKRRDGVLFLKEFCSIAKNLQPPSRSEFFKTL 191
 
Name Accession Description Interval E-value
PP4R3 pfam04802
Phosphatase 4 regulatory subunit 3; This entry represents the Serine/threonine-protein ...
 12-63 1.09e-20

Phosphatase 4 regulatory subunit 3; This entry represents the Serine/threonine-protein phosphatase 4 regulatory subunit 3 (also known as SMEK homolog) PP4R3, which forms a complex with the phosphatase 4 catalytic subunit (PP4c), localising it to the DNA damage repair machinery and regulates its activity. PP4c is involved in developmental progression, chemotaxis, expression of stress response genes and cell movement.


Pssm-ID: 461435  Cd Length: 191  Bit Score: 89.82  E-value: 1.09e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907079514  12 EDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTL 63
Cdd:pfam04802 140 EDEEFLKELFAILRDPETSDEKRRDGVLFLKEFCSIAKNLQPPSRSEFFKTL 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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