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Conserved domains on  [gi|1907078681|ref|XP_036012005|]
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syntaxin-binding protein 5 isoform X8 [Mus musculus]

Protein Classification

WD40 and LLGL domain-containing protein( domain architecture ID 11456846)

WD40 and LLGL domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LLGL pfam08366
LLGL2; This domain is found in lethal giant larvae homolog 2 (LLGL2) proteins and ...
 276-385 1.08e-47

LLGL2; This domain is found in lethal giant larvae homolog 2 (LLGL2) proteins and syntaxin-binding proteins like tomosyn. It has been identified in eukaryotes and tends to be found together with WD repeats (pfam00400).


:

Pssm-ID: 462446  Cd Length: 103  Bit Score: 163.90  E-value: 1.08e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681 276 TITPHGkqlkdgkkPEPCKPILKVELKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETP 355
Cdd:pfam08366   1 PTTPYG--------PFPCKAITKILWKTTKTGEPFIIFSGGMPRASYGDRHCITVMHGKKHTVFDFTSKVIDFFTLCESP 72

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1907078681 356 YPN-DFQEPYAVVVLLEKDLVLIDLAQNGYP 385
Cdd:pfam08366  73 DPNaEFDDPYALVVLLEEELVVIDLTTPGWP 103
WD40 COG2319
WD40 repeat [General function prediction only];
49-281 9.24e-17

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 9.24e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681  49 LCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQ-HDSGAAVIQLQFLINEGALVSALADDTLHLWN 127
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTlTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681 128 LRQKRPavLHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVES----FTLSGyvimwnkaielsskaHPGPV--VH 201
Cdd:COG2319   191 LATGKL--LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATgkllRTLTG---------------HSGSVrsVA 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681 202 ISDNpmdeGKLLI-GFESGTVVLWDLKSKKADYRYT-YDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPaKPVQTITP 279
Cdd:COG2319   254 FSPD----GRLLAsGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTG 328


                  ..
gi 1907078681 280 HG 281
Cdd:COG2319   329 HT 330
 
Name Accession Description Interval E-value
LLGL pfam08366
LLGL2; This domain is found in lethal giant larvae homolog 2 (LLGL2) proteins and ...
 276-385 1.08e-47

LLGL2; This domain is found in lethal giant larvae homolog 2 (LLGL2) proteins and syntaxin-binding proteins like tomosyn. It has been identified in eukaryotes and tends to be found together with WD repeats (pfam00400).


Pssm-ID: 462446  Cd Length: 103  Bit Score: 163.90  E-value: 1.08e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681 276 TITPHGkqlkdgkkPEPCKPILKVELKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETP 355
Cdd:pfam08366   1 PTTPYG--------PFPCKAITKILWKTTKTGEPFIIFSGGMPRASYGDRHCITVMHGKKHTVFDFTSKVIDFFTLCESP 72

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1907078681 356 YPN-DFQEPYAVVVLLEKDLVLIDLAQNGYP 385
Cdd:pfam08366  73 DPNaEFDDPYALVVLLEEELVVIDLTTPGWP 103
WD40 COG2319
WD40 repeat [General function prediction only];
49-281 9.24e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 9.24e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681  49 LCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQ-HDSGAAVIQLQFLINEGALVSALADDTLHLWN 127
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTlTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681 128 LRQKRPavLHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVES----FTLSGyvimwnkaielsskaHPGPV--VH 201
Cdd:COG2319   191 LATGKL--LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATgkllRTLTG---------------HSGSVrsVA 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681 202 ISDNpmdeGKLLI-GFESGTVVLWDLKSKKADYRYT-YDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPaKPVQTITP 279
Cdd:COG2319   254 FSPD----GRLLAsGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTG 328


                  ..
gi 1907078681 280 HG 281
Cdd:COG2319   329 HT 330
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-280 1.95e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 1.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681  62 SALAFDPVQKILAVGTQTGALRLFGRPGVEC---YCQHDSgaAVIQLQFLINEGALVSALADDTLHLWNLRQKRPavLHS 138
Cdd:cd00200    55 RDVAASADGTYLASGSSDKTIRLWDLETGECvrtLTGHTS--YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC--LTT 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681 139 LKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESF----TLSGyvimwnkaielsskaHPGPVVHISDNPmDEGKLLI 214
Cdd:cd00200   131 LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGkcvaTLTG---------------HTGEVNSVAFSP-DGEKLLS 194

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907078681 215 GFESGTVVLWDLKSKKADYRYTY-DEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPaKPVQTITPH 280
Cdd:cd00200   195 SSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG-ECVQTLSGH 260
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 238-266 1.18e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.18e-03
                           10        20
                   ....*....|....*....|....*....
gi 1907078681  238 DEAIHSVAWHHEGKQFICSHSDGTLTIWN 266
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
LLGL pfam08366
LLGL2; This domain is found in lethal giant larvae homolog 2 (LLGL2) proteins and ...
 276-385 1.08e-47

LLGL2; This domain is found in lethal giant larvae homolog 2 (LLGL2) proteins and syntaxin-binding proteins like tomosyn. It has been identified in eukaryotes and tends to be found together with WD repeats (pfam00400).


Pssm-ID: 462446  Cd Length: 103  Bit Score: 163.90  E-value: 1.08e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681 276 TITPHGkqlkdgkkPEPCKPILKVELKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETP 355
Cdd:pfam08366   1 PTTPYG--------PFPCKAITKILWKTTKTGEPFIIFSGGMPRASYGDRHCITVMHGKKHTVFDFTSKVIDFFTLCESP 72

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1907078681 356 YPN-DFQEPYAVVVLLEKDLVLIDLAQNGYP 385
Cdd:pfam08366  73 DPNaEFDDPYALVVLLEEELVVIDLTTPGWP 103
WD40 COG2319
WD40 repeat [General function prediction only];
49-281 9.24e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 9.24e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681  49 LCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQ-HDSGAAVIQLQFLINEGALVSALADDTLHLWN 127
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTlTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681 128 LRQKRPavLHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVES----FTLSGyvimwnkaielsskaHPGPV--VH 201
Cdd:COG2319   191 LATGKL--LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATgkllRTLTG---------------HSGSVrsVA 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681 202 ISDNpmdeGKLLI-GFESGTVVLWDLKSKKADYRYT-YDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPaKPVQTITP 279
Cdd:COG2319   254 FSPD----GRLLAsGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTG 328


                  ..
gi 1907078681 280 HG 281
Cdd:COG2319   329 HT 330
WD40 COG2319
WD40 repeat [General function prediction only];
62-269 9.58e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 9.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681  62 SALAFDPVQKILAVGTQTGALRLFGRPGVEC-YCQHDSGAAVIQLQFLINEGALVSALADDTLHLWNLRQKRPavLHSLK 140
Cdd:COG2319   208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLlRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL--LRTLT 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681 141 FCRERVTFCHLPFQSKWLYVGTERGNIHIVNVES----FTLSGyvimwnkaielsskaHPGPVVHISDNPmDEGKLLIGF 216
Cdd:COG2319   286 GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATgkllRTLTG---------------HTGAVRSVAFSP-DGKTLASGS 349

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907078681 217 ESGTVVLWDLKSKKADYRYT-YDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRS 269
Cdd:COG2319   350 DDGTVRLWDLATGELLRTLTgHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
48-281 1.69e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 1.69e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681  48 QLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQ-HDSGAAVIQLQFLINEGALVSALADDTLHLW 126
Cdd:COG2319    68 GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTlTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681 127 NLRQKRP-AVLHSLKFCRERVTFCHlpfQSKWLYVGTERGNIHIVNVES----FTLSGyvimwnkaielsskaHPGPVVH 201
Cdd:COG2319   148 DLATGKLlRTLTGHSGAVTSVAFSP---DGKLLASGSDDGTVRLWDLATgkllRTLTG---------------HTGAVRS 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681 202 ISDNPmdEGKLLI-GFESGTVVLWDLKSKKADYRYT-YDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPaKPVQTITP 279
Cdd:COG2319   210 VAFSP--DGKLLAsGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG-ELLRTLTG 286


                  ..
gi 1907078681 280 HG 281
Cdd:COG2319   287 HS 288
WD40 COG2319
WD40 repeat [General function prediction only];
52-281 1.26e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.49  E-value: 1.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681  52 TVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADDTLHLWNLRQK 131
Cdd:COG2319    31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681 132 RPavLHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVES----FTLSGyvimwnkaielsskaHPGPV--VHISDN 205
Cdd:COG2319   111 LL--LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATgkllRTLTG---------------HSGAVtsVAFSPD 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907078681 206 pmdeGKLLI-GFESGTVVLWDLKSKKADYRYT-YDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPaKPVQTITPHG 281
Cdd:COG2319   174 ----GKLLAsGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG-KLLRTLTGHS 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-280 1.95e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 1.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681  62 SALAFDPVQKILAVGTQTGALRLFGRPGVEC---YCQHDSgaAVIQLQFLINEGALVSALADDTLHLWNLRQKRPavLHS 138
Cdd:cd00200    55 RDVAASADGTYLASGSSDKTIRLWDLETGECvrtLTGHTS--YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC--LTT 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681 139 LKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESF----TLSGyvimwnkaielsskaHPGPVVHISDNPmDEGKLLI 214
Cdd:cd00200   131 LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGkcvaTLTG---------------HTGEVNSVAFSP-DGEKLLS 194

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907078681 215 GFESGTVVLWDLKSKKADYRYTY-DEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPaKPVQTITPH 280
Cdd:cd00200   195 SSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG-ECVQTLSGH 260
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-280 3.43e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.83  E-value: 3.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681  62 SALAFDPVQKILAVGTQTGALRLFGRPGVEC---YCQHDSGaaVIQLQFLINEGALVSALADDTLHLWNLRQKRpaVLHS 138
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELlrtLKGHTGP--VRDVAASADGTYLASGSSDKTIRLWDLETGE--CVRT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681 139 LKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSgYVImwnkaielssKAHPGPVVHISDNPmdEGKLLIGFES 218
Cdd:cd00200    89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL-TTL----------RGHTDWVNSVAFSP--DGTFVASSSQ 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907078681 219 -GTVVLWDLKSKKADYRYT-YDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSpAKPVQTITPH 280
Cdd:cd00200   156 dGTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST-GKCLGTLRGH 218
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-266 1.14e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.29  E-value: 1.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681  62 SALAFDPVQKILAVGTQTGALRLF-GRPGVECYCQHDSGAAVIQLQFLINEGALVSALADDTLHLWNLRQKRPavLHSLK 140
Cdd:cd00200    97 SSVAFSPDGRILSSSSRDKTIKVWdVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC--VATLT 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681 141 FCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYVImwnkaielsskAHPGPVVHISDNPmdEGKLLI-GFESG 219
Cdd:cd00200   175 GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR-----------GHENGVNSVAFSP--DGYLLAsGSEDG 241

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1907078681 220 TVVLWDLKSKKADYRYT-YDEAIHSVAWHHEGKQFICSHSDGTLTIWN 266
Cdd:cd00200   242 TIRVWDLRTGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-280 4.27e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 4.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681  96 HDSGaaVIQLQFLINEGALVSALADDTLHLWNLRQKRPA---VLHSLKfcrerVTFCHLPFQSKWLYVGTERGNIHIVNV 172
Cdd:cd00200     8 HTGG--VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLrtlKGHTGP-----VRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078681 173 ESFTLSGYVimwnkaielssKAHPGPV--VHISDNpmdeGKLLIG-FESGTVVLWDLKSKKADYRYTY-DEAIHSVAWHH 248
Cdd:cd00200    81 ETGECVRTL-----------TGHTSYVssVAFSPD----GRILSSsSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSP 145

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1907078681 249 EGKQFICSHSDGTLTIWNVRSpAKPVQTITPH 280
Cdd:cd00200   146 DGTFVASSSQDGTIKLWDLRT-GKCVATLTGH 176
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 238-266 1.18e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.18e-03
                           10        20
                   ....*....|....*....|....*....
gi 1907078681  238 DEAIHSVAWHHEGKQFICSHSDGTLTIWN 266
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
56-129 5.37e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.89  E-value: 5.37e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907078681  56 GFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYC---QHDsgAAVIQLQFLINEGALVSALADDTLHLWNLR 129
Cdd:COG2319   328 GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRtltGHT--GAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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