NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907076912|ref|XP_036011842|]
View 

required for meiotic nuclear division protein 1 homolog isoform X4 [Mus musculus]

Protein Classification

RMD1 family protein( domain architecture ID 10495421)

RMD1 family protein contains a DUF155 domain; similar to Saccharomyces cerevisiae sporulation protein RMD1, which is required for sporulation where it is believed to have a role in meiotic nuclear division, and human required for meiotic nuclear division protein 1 homolog (RMND1), which is required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
DUF155 pfam02582
RMND1/Sif2-Sif3/Mrx10, DUF155; This entry represents a domain found in RMND1 from mammals, ...
6-160 1.03e-49

RMND1/Sif2-Sif3/Mrx10, DUF155; This entry represents a domain found in RMND1 from mammals, Sif2/Sif3 from fission yeasts and Rmd1/Rmd8/YDR282C (Mrx10) from budding yeasts. RMND1 and its yeast homolog, Mrx10, are mitochondrial proteins required for mitochondrial translation. Rmd1 and Rmd8 are cytoplasmic proteins required for sporulation.


:

Pssm-ID: 460604  Cd Length: 173  Bit Score: 159.31  E-value: 1.03e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907076912   6 QVLERHETQPYEVALVHWENEELNYIkTEGQSKLHRGEIKLNSeldldDAILEKFAFSNALCLSVKLAIWEATLDKFIES 85
Cdd:pfam02582  25 DLLRFAEEPSIPPLLEEEETEEFDYV-YPSESRIQNDIIVLGS-----DDLLAKLAISHALAQSVKLSVFEELLDKLLES 98
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907076912  86 IQSIPEALKAGKKVKLSHKEVMQKMGELFALRHRINLSSDFLITPDFYWDRANLEELYDKTCQFLSITRRVKVMN 160
Cdd:pfam02582  99 TESIPEELAKTGKLKLSRKELLKKIGELLLLRHDINLNSELLDTPDFFWEEPELEPLYEALREYLEIKERIEVLN 173
 
Name Accession Description Interval E-value
DUF155 pfam02582
RMND1/Sif2-Sif3/Mrx10, DUF155; This entry represents a domain found in RMND1 from mammals, ...
6-160 1.03e-49

RMND1/Sif2-Sif3/Mrx10, DUF155; This entry represents a domain found in RMND1 from mammals, Sif2/Sif3 from fission yeasts and Rmd1/Rmd8/YDR282C (Mrx10) from budding yeasts. RMND1 and its yeast homolog, Mrx10, are mitochondrial proteins required for mitochondrial translation. Rmd1 and Rmd8 are cytoplasmic proteins required for sporulation.


Pssm-ID: 460604  Cd Length: 173  Bit Score: 159.31  E-value: 1.03e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907076912   6 QVLERHETQPYEVALVHWENEELNYIkTEGQSKLHRGEIKLNSeldldDAILEKFAFSNALCLSVKLAIWEATLDKFIES 85
Cdd:pfam02582  25 DLLRFAEEPSIPPLLEEEETEEFDYV-YPSESRIQNDIIVLGS-----DDLLAKLAISHALAQSVKLSVFEELLDKLLES 98
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907076912  86 IQSIPEALKAGKKVKLSHKEVMQKMGELFALRHRINLSSDFLITPDFYWDRANLEELYDKTCQFLSITRRVKVMN 160
Cdd:pfam02582  99 TESIPEELAKTGKLKLSRKELLKKIGELLLLRHDINLNSELLDTPDFFWEEPELEPLYEALREYLEIKERIEVLN 173
Rmd1 COG1723
Mitochondrial translation protein, Rmd1/RMND1/DUF155 family [Translation, ribosomal structure ...
1-206 1.08e-40

Mitochondrial translation protein, Rmd1/RMND1/DUF155 family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441329  Cd Length: 261  Bit Score: 138.80  E-value: 1.08e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907076912   1 MKHVMQVLERHETQPYEVAlvhwENEELNY-IKTEGQSKLHRGEIKLNselDLDDAILEkfAFSNALCLSVKLAIWEATL 79
Cdd:COG1723    64 EADFLDELKPFVEEPLEEP----ESEEFEIeIGPDEEDRVEEDHIILP---DLDPERLL--LVSDVLAQSVALARYEERV 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907076912  80 DKFIESIQSIPEALKAGKKVKLSHKEVMQKMGELFALRHRINLSSDFLITPDFYWDRANLEELYDKTCQFLSITRRVKVM 159
Cdd:COG1723   135 AALFDEIEPLAQELAKKGKLPLSRKELLKKIGKLLLIKHRIILRVEILDKPEFFWENPELERLYLRLEDEFELKERYEAL 214
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1907076912 160 NEKLQHCMELTDLMRNHLNEKRALRLEWMIVILITIEVMFELGRVFF 206
Cdd:COG1723   215 NRKLEIIHETLETLLDLLQHRHSSRLEWIIIILIVVEIVLTLYEKFF 261
 
Name Accession Description Interval E-value
DUF155 pfam02582
RMND1/Sif2-Sif3/Mrx10, DUF155; This entry represents a domain found in RMND1 from mammals, ...
6-160 1.03e-49

RMND1/Sif2-Sif3/Mrx10, DUF155; This entry represents a domain found in RMND1 from mammals, Sif2/Sif3 from fission yeasts and Rmd1/Rmd8/YDR282C (Mrx10) from budding yeasts. RMND1 and its yeast homolog, Mrx10, are mitochondrial proteins required for mitochondrial translation. Rmd1 and Rmd8 are cytoplasmic proteins required for sporulation.


Pssm-ID: 460604  Cd Length: 173  Bit Score: 159.31  E-value: 1.03e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907076912   6 QVLERHETQPYEVALVHWENEELNYIkTEGQSKLHRGEIKLNSeldldDAILEKFAFSNALCLSVKLAIWEATLDKFIES 85
Cdd:pfam02582  25 DLLRFAEEPSIPPLLEEEETEEFDYV-YPSESRIQNDIIVLGS-----DDLLAKLAISHALAQSVKLSVFEELLDKLLES 98
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907076912  86 IQSIPEALKAGKKVKLSHKEVMQKMGELFALRHRINLSSDFLITPDFYWDRANLEELYDKTCQFLSITRRVKVMN 160
Cdd:pfam02582  99 TESIPEELAKTGKLKLSRKELLKKIGELLLLRHDINLNSELLDTPDFFWEEPELEPLYEALREYLEIKERIEVLN 173
Rmd1 COG1723
Mitochondrial translation protein, Rmd1/RMND1/DUF155 family [Translation, ribosomal structure ...
1-206 1.08e-40

Mitochondrial translation protein, Rmd1/RMND1/DUF155 family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441329  Cd Length: 261  Bit Score: 138.80  E-value: 1.08e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907076912   1 MKHVMQVLERHETQPYEVAlvhwENEELNY-IKTEGQSKLHRGEIKLNselDLDDAILEkfAFSNALCLSVKLAIWEATL 79
Cdd:COG1723    64 EADFLDELKPFVEEPLEEP----ESEEFEIeIGPDEEDRVEEDHIILP---DLDPERLL--LVSDVLAQSVALARYEERV 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907076912  80 DKFIESIQSIPEALKAGKKVKLSHKEVMQKMGELFALRHRINLSSDFLITPDFYWDRANLEELYDKTCQFLSITRRVKVM 159
Cdd:COG1723   135 AALFDEIEPLAQELAKKGKLPLSRKELLKKIGKLLLIKHRIILRVEILDKPEFFWENPELERLYLRLEDEFELKERYEAL 214
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1907076912 160 NEKLQHCMELTDLMRNHLNEKRALRLEWMIVILITIEVMFELGRVFF 206
Cdd:COG1723   215 NRKLEIIHETLETLLDLLQHRHSSRLEWIIIILIVVEIVLTLYEKFF 261
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH